Cardiac Physiology & Biophysics




Giommi, A., Gurgel, A. R. B., Smith, G. L., Workman, A. J. (2023) Does the small conductance Ca2+-activated K+ current ISK flow under physiological conditions in rabbit and human atrial isolated cardiomyocytes? Journal of Molecular and Cellular Cardiology, 183, pp. 70-80. (doi: 10.1016/j.yjmcc.2023.09.002)

Da Silva Costa, A., Ghouri, I., Johnston, A., Mcglynn, K., McNair, A., Bowman, P., Malik, N., Hurren, J., Bingelis, T., Dunne, M., Smith, G. L., Kemi, O. J. (2023) Electrically stimulated in vitro heart cell mimic of acute exercise reveals novel immediate cellular responses to exercise: reduced contractility and metabolism, but maintained calcium cycling and increased myofilament calcium sensitivity Cell Biochemistry and Function,

Simitev, R. D., Al dawoud, A., Aziz, M. H.N., Myles, R., Smith, G. L. (2023) Phenomenological analysis of simple ion channel block in large populations of uncoupled cardiomyocytes Mathematical Medicine and Biology, 40, pp. 175-198. (doi: 10.1093/imammb/dqad001)

Lu, H. R., Van de Sande, D., Mohammadreza, G., Watters, T., Burton, F., Pham, L., Altrocchi, C., Gallacher, D. J., Smith, G. (2023) Are more mature hiPSC-cardiomyocytes better for the detection of drug-induced cardiotoxicity? Biomolecules, 13, (doi: 10.3390/biom13040676)

Kuo, C.-W. S., Dobi, S., Gök, C., Da Silva Costa, A., Main, A., Robertson-Gray, O., Baptista-Hon, D., Wypijewski, K. J., Costello, H., Hales, T. G., MacQuaide, N., Smith, G. L., Fuller, W. (2023) Palmitoylation of the pore-forming subunit of Ca(v)1.2 controls channel voltage sensitivity and calcium transients in cardiac myocytes Proceedings of the National Academy of Sciences of the United States of America, 120, (doi: 10.1073/pnas.2207887120)

Alexander, C., Bishop, M. J., Gilchrist, R. J., Burton, F. L., Smith, G. L., Myles, R. C. (2023) Initiation of ventricular arrhythmia in the acquired long QT syndrome Cardiovascular Research, 119, pp. 465-476. (doi: 10.1093/cvr/cvac103)


Saxena, P., Myles, R. C., Smith, G. L., Workman, A. J. (2022) Adrenoceptor sub-type involvement in Ca2+ current stimulation by noradrenaline in human and rabbit atrial myocytes Pflügers Archiv European Journal of Physiology, 474, pp. 1311-1321. (doi: 10.1007/s00424-022-02746-z)

Lachaud, Q., Aziz, M. H. N., Burton, F. L., Macquaide, N., Myles, R. C., Simitev, R. D., Smith, G. L. (2022) Electrophysiological heterogeneity in large populations of rabbit ventricular cardiomyocytes Cardiovascular Research, 118, pp. 3112-3125. (doi: 10.1093/cvr/cvab375)

Bruegmann, T., Smith, G. L., Lehnart, S. E. (2022) Editorial: Cardiac optogenetics: Using light to observe and excite the heart Frontiers in Physiology, 13, (doi: 10.3389/fphys.2022.1031062)

Main, A., Bogusalvskyii, A., Howie, J., Kuo, C.-W., Rankin, A., Burton, F. L., Smith, G. L., Hajjar, R., Baillie, G. S., Campbell, K. S., Shattock, M. J., Fuller, W. (2022) Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies Frontiers in Physiology, 13, (doi: 10.3389/fphys.2022.1023237)

Fertig, B., Ling, J., Nollet, E. E., Dobi, S., Busiau, T., Ishikawa, K., Yamada, K., Lee, A., Kho, C., Wills, L., Tibbo, A. J., Scott, M., Grant, K., Campbell, K. S., Birks, E. J., MacQuaide, N., Hajjar, R., Smith, G. L., van der Velden, J., Baillie, G. (2022) SUMOylation does not affect cardiac troponin I stability but alters indirectly the development of force in response to Ca2+ FEBS Journal, 289, pp. 6267-6285. (doi: 10.1111/febs.16537)

Malagueta-Vieira, L., Fernández-Ruocco, J., Hortigon, M., Zamora, V., Zayas-Arrabal, J., Echeazarra, L., Smith, G. L., Vila Petroff, M., Medei, E., Casis, Ó., Gallego, M. (2022) Metformin reduces potassium currents and prolongs repolarization in non-diabetic heart International Journal of Molecular Sciences, 23, (doi: 10.3390/ijms23116021)

He, W., McCarroll, C. S., Nather, K., Ford, K., Mangion, K., Riddell, A., O'Toole, D., Zaeri, A., Corcoran, D., Carrick, D., Lee, M. M.Y., McEntegart, M., Davie, A., Good, R., Lindsay, M. M., Eteiba, H., Rocchiccioli, P., Watkins, S., Hood, S., Shaukat, A., McArthur, L., Elliott, E. B., McClure, J., Hawksby, C., Martin, T., Petrie, M. C., Oldroyd, K. G., Smith, G. L., Channon, K. M., Berry, C., Nicklin, S. A., Loughrey, C. M. (2022) Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size Cardiovascular Research, 118, pp. 1535-1547. (doi: 10.1093/cvr/cvab204)

Tibbo, A. J., Mika, D., Dobi, S., Ling, J., McFall, A., Tejeda, G. S., Blair, C., MacLeod, R., MacQuaide, N., Gök, C., Fuller, W., Smith, B. O., Smith, G. L., Vandecasteele, G., Brand, T., Baillie, G. S. (2022) Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins Journal of Molecular and Cellular Cardiology, 165, pp. 86-102. (doi: 10.1016/j.yjmcc.2022.01.001)

Dietrichs, E. S., Smith, G. L. (2022) Prediction of ventricular arrhythmias by QRS/QTc - ratio in Citalopram or Escitalopram intoxication Frontiers in Medicine, 9, (doi: 10.3389/fmed.2022.866454)

Huethorst, E., Mortensen, P., Simitev, R. D., Gao, H., Pohjolainen, L., Talman, V., Ruskoaho, H., Burton, F. L., Gadegaard, N., Smith, G. L. (2022) Conventional rigid 2D substrates cause complex contractile signals in monolayers of human induced pluripotent stem cell derived cardiomyocytes Journal of Physiology, 600, pp. 483-507. (doi: 10.1113/JP282228)

Faulkner-Jones, A., Zamora, V., Hortigon-Vinagre, M. P., Wang, W., Ardron, M., Smith, G. L., Shu, W. (2022) A bioprinted heart-on-a-chip with human pluripotent stem cell-derived cardiomyocytes for drug evaluation Bioengineering, 9, (doi: 10.3390/bioengineering9010032)


Müllenbroich, M. C., Kelly, A., Acker, C., Bub, G., Bruegmann, T., Di Bona, A., Entcheva, E., Ferrantini, C., Kohl, P., Lehnart, S. E., Mongillo, M., Parmeggiani, C., Richter, C., Sasse, P., Zaglia, T., Sacconi, L., Smith, G. L. (2021) Novel optics-based approaches for cardiac electrophysiology: a review Frontiers in Physiology, 12, (doi: 10.3389/fphys.2021.769586)

Sveberg Dietrichs, E., Myles, R., Smith, G. (2021) Is hypothermia more neuroprotective than avoiding fever after cardiac arrest? Cardiovascular Research, 117, pp. e159-e161. (doi: 10.1093/cvr/cvab297)

Holmes, A. P., Saxena, P., Kabir, S. N., O'Shea, C., Kuhlmann, S. M., Gupta, S., Fobian, D., Apicella, C., O'Reilly, M., Syeda, F., Reyat, J. S., Smith, G. L., Workman, A. J., Pavlovic, D., Fabritz, L., Kirchhof, P. (2021) The atrial resting membrane potential confers sodium current sensitivity to propafenone, flecainide and dronedarone Heart Rhythm, 18, pp. 1212-1220. (doi: 10.1016/j.hrthm.2021.03.016)

Bowman, P. R.T., Smith, G. L., Gould, G. W. (2021) Run for your life: can exercise be used to effectively target GLUT4 in diabetic cardiac disease? PeerJ, 9, (doi: 10.7717/peerj.11485)

Mortensen, P., Gao, H., Smith, G., Simitev, R. D. (2021) Action potential propagation and block in a model of atrial tissue with myocyte-fibroblast coupling Mathematical Medicine and Biology, 38, pp. 106-131. (doi: 10.1093/imammb/dqaa014)

Hortigon-Vinagre, M.P., Zamora, V., Burton, F. L., Smith, G. L. (2021) The use of voltage sensitive dye di-4-ANEPPS and video-based contractility measurements to assess drug effects on excitation-contraction coupling in human induced pluripotent stem cell-derived cardiomyocytes Journal of Cardiovascular Pharmacology, 77, pp. 280-290. (doi: 10.1097/FJC.0000000000000937)

Mortensen, P., Gao, H., Smith, G., Simitev, R. D. (2021) Addendum: Action potential propagation and block in a model of atrial tissue with myocyte-fibroblast coupling Mathematical Medicine and Biology, 38, pp. 292-298. (doi: 10.1093/imammb/dqab005)

Da Silva Costa, A., Mortensen, P., Hortigon-Vinagre, M. P., van der Heyden, M. A. G., Burton, F. L., Gao, H., Simitev, R. D., Smith, G. L. (2021) Electrophysiology of hiPSC-cardiomyocytes co-cultured with HEK cells expressing the inward rectifier channel International Journal of Molecular Sciences, 22, (doi: 10.3390/ijms22126621)


Dietrichs, E. S., McGlynn, K., Allan, A., Connolly, A., Bishop, M., Burton, F., Kettlewell, S., Myles, R., Tveita, T., Smith, G. L. (2020) Moderate but not severe hypothermia causes pro-arrhythmic changes in cardiac electrophysiology Cardiovascular Research, 116, pp. 2081-2090. (doi: 10.1093/cvr/cvz309)

Salerno, S., Solvang-Garten, K., Smith, G. L., Stølen, T., Kelly, A. (2020) Two-photon excitation of FluoVolt allows improved interrogation of transmural electrophysiological function in the intact mouse heart Progress in Biophysics and Molecular Biology, 154, pp. 11-20. (doi: 10.1016/j.pbiomolbio.2019.08.007)

Błyszczuk, P., Zuppinger, C., Costa, A., Nurzynska, D., Di Meglio, F., Stellato, M., Agarkova, I., Smith, G., Distler, O., Kania, G. (2020) Activated cardiac fibroblasts control contraction of human fibrotic cardiac microtissues by a β-adrenoreceptor-dependent mechanism Cells, 9, (doi: 10.3390/cells9051270)

Dietrichs, E. S., Tveita, T., Myles, R., Smith, G. (2020) A novel ECG-biomarker for cardiac arrest during hypothermia Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine, 28, (doi: 10.1186/s13049-020-00721-0)

Li, Z., Mirams, G. R., Yoshinaga, T., Ridder, B. J., Han, X., Chen, J. E., Stockbridge, N. L., Wisialowski, T. A., Damiano, B., Severi, S., Morissette, P., Kowey, P. R., Holbrook, M., Smith, G., Rasmusson, R. L., Liu, M., Song, Z., Qu, Z., Leishman, D. J., Steidl‐Nichols, J., Rodriguez, B., Bueno‐Orovio, A., Zhou, X., Passini, E., Edwards, A. G., Morotti, S., Ni, H., Grandi, E., Clancy, C. E., Vandenberg, J., Hill, A., Nakamura, M., Singer, T., Polonchuk, L., Greiter‐Wilke, A., Wang, K., Nave, S., Fullerton, A., Sobie, E. A., Paci, M., Musuamba Tshinanu, F., Strauss, D. G. (2020) General principles for the validation of proarrhythmia risk prediction models: an extension of the CiPA In Silico Strategy Clinical Pharmacology and Therapeutics, 107, pp. 102-111. (doi: 10.1002/cpt.1647)

McArthur, L., Riddell, A., Chilton, L., Smith, G. L., Nicklin, S. A. (2020) Regulation of connexin 43 by interleukin 1β in adult rat cardiac fibroblasts and effects in an adult rat cardiac myocyte: fibroblast co-culture model Heliyon, 6, (doi: 10.1016/j.heliyon.2019.e03031)

de Korte, T., Katili, P. A., Mohd Yusof, N. A.N., van Meer, B. J., Saleem, U., Burton, F. L., Smith, G. L., Clements, P., Mummery, C. L., Eschenhagen, T., Hansen, A., Denning, C. (2020) Unlocking personalized biomedicine and drug discovery with human induced pluripotent stem cell–derived cardiomyocytes: fit for purpose or forever elusive? Annual Review of Pharmacology and Toxicology, 60, pp. 529-551. (doi: 10.1146/annurev-pharmtox-010919-023309)


Gould, G., Bowman, P., Smith, G. (2019) Cardiac SNARE expression in health and disease Frontiers in Endocrinology, 10, (doi: 10.3389/fendo.2019.00881)

Bowman, P. R.T., Smith, G. L., Gould, G. W. (2019) GLUT4 expression and glucose transport in human induced pluripotent stem cell-derived cardiomyocytes PLoS ONE, 14, (doi: 10.1371/journal.pone.0217885)

Kettlewell, S., Saxena, P., Dempster, J., Colman, M. A., Myles, R. C., Smith, G. L., Workman, A. J. (2019) Dynamic‐clamping human and rabbit atrial calcium current: narrowing ICaL window abolishes early afterdepolarisations Journal of Physiology, 597, pp. 3619-3638. (doi: 10.1113/JP277827)

Smith, G. L., Eisner, D. A. (2019) Calcium buffering in the heart in health and disease Circulation, 139, pp. 2358-2371. (doi: 10.1161/circulationaha.118.039329)

Ghouri, I. A., Kelly, A., Salerno, S., Garten, K., Stølen, T., Kemi, O.-J., Smith, G. L. (2019) Corrigendum: Characterization of electrical activity in post-myocardial infarction scar tissue in rat hearts using multiphoton microscopy. Frontiers in Physiology, 10, (doi: 10.3389/fphys.2019.00364)

Dietrichs, E. S., Tveita, T., Smith, G. (2019) Hypothermia and cardiac electrophysiology: a systematic review of clinical and experimental data Cardiovascular Research, 115, pp. 501-509. (doi: 10.1093/cvr/cvy305)

Pfeiffer-Kaushik, E. R., Smith, G. L., Cai, B., Dempsey, G. T., Hortigon-Vinagre, M. P., Zamora, V., Feng, S., Ingermanson, R., Zhu, R., Hariharan, V., Nguyen, C., Pierson, J., Gintant, G. A., Tung, L. (2019) Electrophysiological characterization of drug response in hSC-derived cardiomyocytes using voltage-sensitive optical platforms Journal of Pharmacological and Toxicological Methods, 99, (doi: 10.1016/j.vascn.2019.106612)


Lemme, M., Ulmer, B. M., Lemoine, M. D., Zech, A. T.L., Flenner, F., Ravens, U., Reichenspurner, H., Rol-Garcia, M., Smith, G., Hansen, A., Christ, T., Eschenhagen, T. (2018) Atrial-like engineered heart tissue: an in vitro model of the human atrium Stem Cell Reports, 11, pp. 1378-1390. (doi: 10.1016/j.stemcr.2018.10.008)

Connolly, A., Kelly, A., Campos, F. O., Myles, R., Smith, G., Bishop, M. J. (2018) Ventricular endocardial tissue geometry affects stimulus threshold and effective refractory period Biophysical Journal, 115, pp. 2486-2498. (doi: 10.1016/j.bpj.2018.11.003)

Ghouri, I. A., Kelly, A., Salerno, S., Garten, K., Stølen, T., Kemi, O.-J., Smith, G. L. (2018) Characterization of electrical activity in post-myocardial infarction scar tissue in rat hearts using multiphoton microscopy. Frontiers in Physiology, 9, (doi: 10.3389/fphys.2018.01454)

van Meer, B. J., Sala, L., Tertoolen, L. G.J., Smith, G. L., Burton, F. L., Mummery, C. L. (2018) Quantification of muscle contraction in vitro and in vivo using MUSCLEMOTION software: from stem cell-derived cardiomyocytes to zebrafish and human hearts Current Protocols in Human Genetics, 99, (doi: 10.1002/cphg.67)

Blinova, K., Dang, Q., Millard, D., Smith, G., Pierson, J., Guo, L., Brock, M., Lu, H. R., Kraushaar, U., Zeng, H., Shi, H., Zhang, X., Sawada, K., Osada, T., Kanda, Y., Sekino, Y., Pang, L., Feaster, T. K., Kettenhofen, R., Stockbridge, N., Strauss, D. G., Gintant, G. (2018) International multisite study of human-induced pluripotent stem cell-derived cardiomyocytes for drug proarrhythmic potential assessment Cell Reports, 24, pp. 3582-3592. (doi: 10.1016/j.celrep.2018.08.079)

Høydal, M. A., Kirkeby-Garstad, I., Karevold, A., Wiseth, R., Haaverstad, R., Wahba, A., Stølen, T. L., Contu, R., Ellingsen, Ø., Smith, G. L. S., Kemi, O. J., Wisløff, U. (2018) Human cardiomyocyte calcium handling and transverse tubules in mid-stage of post-myocardial-infarction heart failure ESC Heart Failure, 5, pp. 332-342. (doi: 10.1002/ehf2.12271)

Bruegmann, T., Smith, G. L. (2018) Macrophages: new players in cardiac ageing? Cardiovascular Research, 114, pp. e47-e49. (doi: 10.1093/cvr/cvy047)

Kelly, A., Salerno, S., Connolly, A., Bishop, M., Charpentier, F., Stølen, T., Smith, G. L. (2018) Normal interventricular differences in tissue architecture underlie right ventricular susceptibility to conduction abnormalities in a mouse model of Brugada syndrome Cardiovascular Research, 114, pp. 724-736. (doi: 10.1093/cvr/cvx244)

Boyden, P. A., Smith, G. L. (2018) Ca2+ leak, what is it? Why should we care? Can it be managed? Heart Rhythm, 15, pp. 607-614. (doi: 10.1016/j.hrthm.2017.11.018)

Malmo, V., Kelly, A., Garten, K. S., Stolen, T., Rolim, N. P. L., Wisloff, U., Smith, G., Loennechen, J. P. (2018) Aerobic interval training prevents age-dependent vulnerability to atrial fibrillation in rodents Frontiers in Physiology, 9, (doi: 10.3389/fphys.2018.00206)

Sala, L., van Meer, B. J., Tertoolen, L. T., Bakkers, J., Bellin, M., Davis, R. P., Denning, C. N., Dieben, M. A., Eschenhagen, T., Giacomelli, E., Grandela, C., Hansen, A., Holman, E., Jongbloed, M. R., Kamel, S. M., Koopman, C. D., Lachaud, Q., Mannhardt, I., Mol, M. P., Mosqueira, D., Orlova, V. V., Passier, R., Ribeiro, M. C., Saleem, U., Smith, G., Burton, F. L.L., Mummery, C. L. (2018) MUSCLEMOTION: a versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo Circulation Research, 122, pp. e5-e16. (doi: 10.1161/CIRCRESAHA.117.312067)

McCarroll, C. S., He, W., Foote, K., Bradley, A., Mcglynn, K., Vidler, F., Nixon, C., Nather, K., Fatta, C., Riddell, A., Bowman, P., Elliott, E. B., Bell, M., Hawksby, C., MacKenzie, S. M., Morrison, L. J., Terry, A., Blyth, K., Smith, G. L., McBride, M. W., Kubin, T., Braun, T., Nicklin, S. A., Cameron, E. R., Loughrey, C. M. (2018) Runx1 deficiency protects against adverse cardiac remodeling after myocardial infarction Circulation, 137, pp. 57-70. (doi: 10.1161/CIRCULATIONAHA.117.028911)

Lachaud, Q., MacQuaide, N., Burton, F., Smith, G. (2018) High-throughput study of rabbit ventricle action potential populations in MI model Biophysical Journal, 114, pp. 625A. (doi: 10.1016/j.bpj.2017.11.3377)


Lei, C. L., Wang, K., Clerx, M., Johnstone, R. H., Hortigon-Vinagre, M. P., Zamora, V., Allan, A., Smith, G. L., Gavaghan, D. J., Mirams, G. R., Polonchuk, L. (2017) Tailoring mathematical models to stem-cell derived cardiomyocyte lines can improve predictions of drug-induced changes to their electrophysiology Frontiers in Physiology, 8, (doi: 10.3389/fphys.2017.00986)

Duncan, G., Firth, K., George, V., Hoang, M. D., Staniforth, A., Smith, G., Denning, C. (2017) Drug-mediated shortening of action potentials in LQTS2 human induced pluripotent stem cell-derived cardiomyocytes Stem Cells and Development, 26, pp. 1695-1705. (doi: 10.1089/scd.2017.0172)

Stevens, K., Denby, L., Patel, R. K., Mark, P. B., Kettlewell, S., Smith, G. L., Clancy, M. J., Delles, C., Jardine, A. G. (2017) Deleterious effects of phosphate on vascular and endothelial function via disruption to the nitric oxide pathway Nephrology Dialysis Transplantation, 32, pp. 1617-1627. (doi: 10.1093/ndt/gfw252)

Lu, H.R., Hortigon-Vinagre, M.P., Zamora, V., Kopljar, I., De Bondt, A., Gallacher, D.J., Smith, G. (2017) Application of optical action potentials in human induced pluripotent stem cells-derived cardiomyocytes to predict drug-induced cardiac arrhythmias Journal of Pharmacological and Toxicological Methods, 87, pp. 53-67. (doi: 10.1016/j.vascn.2017.05.001)

Saxena, P., Hortigon-Vinagre, M.P., Beyl, S., Baburin, I., Andranovits, S., Iqbal, S.M., Costa, A., IJzerman, A.P., Kügler, P., Timin, E., Smith, G.L., Hering, S. (2017) Correlation between human ether-a-go-go-related gene channel inhibition and action potential prolongation British Journal of Pharmacology, 174, pp. 3081-3093. (doi: 10.1111/bph.13942)

Lamore, S. D., Ahlberg, E., Boyer, S., Lamb, M. L., Hortigon-Vinagre, M. P., Rodriguez, V., Smith, G. L., Sagemark, J., Carlsson, L., Bates, S. M., Choy, A. L., Stålring, J., Scott, C. W., Peters, M. F. (2017) Deconvoluting kinase inhibitor induced cardiotoxicity Toxicological Sciences, 158, pp. 213-226. (doi: 10.1093/toxsci/kfx082)

Blinova, K., Stohlman, J., Vicente, J., Chan, D., Johannesen, L., Hortigon-Vinagre, M. P., Zamora Rodriguez, V., Smith, G., Crumb, W. J., Pang, L., Lyn-Cook, B., Ross, J., Brock, M., Chvatal, S., Millard, D., Galeotti, L., Stockbridge, N., Strauss, D. G. (2017) Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias Toxicological Sciences, 155, pp. 234-247. (doi: 10.1093/toxsci/kfw200)


Fattah, C., Nather, K., McCarroll, C. S., Hortigon-Vinagre, M. P., Zamora Rodriguez, V., Flores-Munoz, M., McArthur, L., Zentilin, L., Giacca, M., Touyz, R. M., Smith, G. L., Loughrey, C. M., Nicklin, S. A. (2016) Gene therapy with Angiotensin-(1-9) preserves left ventricular systolic function after myocardial infarction Journal of the American College of Cardiology, 68, pp. 2652-2666. (doi: 10.1016/j.jacc.2016.09.946)

Huethorst, E., Hortigon, M., Zamora-Rodriguez, V., Reynolds, P.M., Burton, F., Smith, G., Gadegaard, N. (2016) Enhanced human-induced pluripotent stem cell derived cardiomyocyte maturation using a dual microgradient substrate ACS Biomaterials Science and Engineering, 2, pp. 2231-2239. (doi: 10.1021/acsbiomaterials.6b00426)

Hortigon-Vinagre, M.P., Zamora, V., Burton, F.L., Green, J., Gintant, G.A., Smith, G.L. (2016) The use of ratiometric fluorescence measurements of the voltage sensitive dye Di-4-ANEPPS to examine action potential characteristics and drug effects on human induced pluripotent stem cell-derived cardiomyocytes Toxicological Sciences, 154, pp. 320-331. (doi: 10.1093/toxsci/kfw171)

Weinberger, F., Breckwoldt, K., Pecha, S., Kelly, A., Geertz, B., Starbatty, J., Yorgan, T., Cheng, K.-H., Lessmann, K., Stolen, T., Scherrer-Crosbie, M., Smith, G., Reichenspurner, H., Hansen, A., Eschenhagen, T. (2016) Cardiac repair in guinea pigs with human engineered heart tissue from induced pluripotent stem cells Science Translational Medicine, 8, pp. 363ra148-363ra148. (doi: 10.1126/scitranslmed.aaf8781)

Crocini, C., Ferrantini, C., Coppini, R., Scardigli, M., Yan, P., Loew, L. M., Smith, G., Cerbai, E., Poggesi, C., Pavone, F. S., Sacconi, L. (2016) Optogenetics design of mechanistically-based stimulation patterns for cardiac defibrillation Scientific Reports, 6, (doi: 10.1038/srep35628)

Høydal, M. A., Stølen, T. O., Kettlewell, S., Maier, L. S., Brown, J. H., Sowa, T., Catalucc, D., Condorelli, G., Kemi, O. J., Smith, G. L., Wisløff, U. (2016) Exercise training reverses myocardial dysfunction induced by CaMKIIδC overexpression by restoring Ca2+-homeostasis Journal of Applied Physiology, 121, pp. 212-220. (doi: 10.1152/japplphysiol.00188.2016)

Baumert, M., Porta, A., Vos, M. A., Malik, M., Couderc, J.-P., Laguna, P., Piccirillo, G., Smith, G. L., Tereshchenko, L. G., Volders, P. G.A. (2016) QT interval variability in body surface ECG: measurement, physiological basis, and clinical value: position statement and consensus guidance endorsed by the European Heart Rhythm Association jointly with the ESC Working Group on Cardiac Cellular Electrophysiology Europace, 18, pp. 925-944. (doi: 10.1093/europace/euv405)

Nisbet, A. M., Camelliti, P., Walker, N. L., Burton, F. L., Cobbe, S. M., Kohl, P., Smith, G. L. (2016) Prolongation of atrio-ventricular node conduction in a rabbit model of ischaemic cardiomyopathy: role of fibrosis and connexin remodelling Journal of Molecular and Cellular Cardiology, 94, pp. 54-64. (doi: 10.1016/j.yjmcc.2016.03.011)


Rog-Zielinska, E.A., Craig, M.-A., Manning, J.R., Richardson, R.V., Gowans, G.J., Dunbar, D.R., Gharbi, K., Kenyon, C.J., Holmes, M.C., Hardie, D.G., Smith, G.L., Chapman, K.E. (2015) Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1α Cell Death and Differentiation, 22, pp. 1106-1116. (doi: 10.1038/cdd.2014.181)

McArthur, L., Chilton, L., Smith, G. L., Nicklin, S. A. (2015) Electrical consequences of cardiac myocyte: fibroblast coupling Biochemical Society Transactions, 43, pp. 513-518. (doi: 10.1042/BST20150035)

Smith, G. L., MacQuaide, N. (2015) The direct actions of flecainide on the human cardiac ryanodine receptor: keeping open the debate on the mechanism of action of local anesthetics in CPVT Circulation Research, 116, pp. 1284-1286. (doi: 10.1161/CIRCRESAHA.115.306298)

Ghouri, I. A., Kelly, A., Burton, F. L., Smith, G. L., Kemi, O. J. (2015) 2-photon excitation fluorescence microscopy enables deeper high-resolution imaging of voltage and Ca2+in intact mice, rat, and rabbit hearts Journal of Biophotonics, 8, pp. 112-123. (doi: 10.1002/jbio.201300109)

MacCannell, K.A., Chilton, L., Smith, G.L., Giles, W.R. (2015) Mathematical simulations of sphingosine-1-phosphate actions on mammalian ventricular myofibroblasts and myocytes Springer


Campbell, A. S., Johnstone, S. R., Baillie, G. S., Smith, G. (2014) β-Adrenergic modulation of myocardial conduction velocity: Connexins vs. sodium current Journal of Molecular and Cellular Cardiology, 77, pp. 147-154. (doi: 10.1016/j.yjmcc.2014.09.030)

Boyman, L., Chikando, A. C., Williams, G. S.B., Khairallah, R. J., Kettlewell, S., Ward, C. W., Smith, G. L., Kao, J. P.Y., Lederer, W. J. (2014) Calcium movement in cardiac mitochondria Biophysical Journal, 107, pp. 1289-1301. (doi: 10.1016/j.bpj.2014.07.045)

Haviland, S., Cleemann, L., Kettlewell, S., Smith, G. L., Morad, M. (2014) Diversity of mitochondrial Ca²⁺ signaling in rat neonatal cardiomyocytes: evidence from a genetically directed Ca²⁺ probe mitycam-E31Q Cell Calcium, 56, pp. 133-146. (doi: 10.1016/j.ceca.2014.06.001)

O-Uchi, J., Jhun, B. S., Xu, S., Hurst, S., Raffaello, A., Liu, X., Yi, B., Zhang, H., Gross, P., Mishra, J., Ainbinder, A., Kettlewell, S., Smith, G. L., Dirksen, R. T., Wang, W., Rizzuto, R., Sheu, S.-S. (2014) Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter Antioxidants and Redox Signaling, 21, pp. 863-879. (doi: 10.1089/ars.2013.5394)

Liu, T., Takimoto, E., Dimaano, V. L., DeMazumder, D., Kettlewell, S., Smith, G., Sidor, A., Abraham, T. P., O'Rourke, B. (2014) Inhibiting mitochondrial Na+/Ca2+ exchange prevents sudden death in a guinea pig model of heart failure Circulation Research, 115, pp. 44-54. (doi: 10.1161/CIRCRESAHA.115.303062)

Høydal, M.A., Stølen, T.O., Johnsen, A.B., Alvez, M., Catalucci, D., Condorelli, G., Koch, L.G., Britton, S.L., Smith, G.L., Wisløff, U. (2014) Reduced aerobic capacity causes leaky ryanodine receptors that trigger arrhythmia in a rat strain artificially selected and bred for low aerobic running capacity Acta Physiologica, 210, pp. 854-864. (doi: 10.1111/apha.12238)

Hohendanner, F., Walther, S., Maxwell, J. T., Kettlewell, S., Awad, S., Smith, G., Lonchyna, V. A., Blatter, L. A. (2014) Inositol-1,4,5-trisphosphate induced Ca2+release and excitation-contraction coupling in atrial myocytes from normal and failing hearts Journal of Physiology, 593, pp. 1459-1477. (doi: 10.1113/jphysiol.2014.283226)

Campbell, A. S., Burton, F. L., Baillie, G., Smith, G. L. (2014) Action potential conduction velocity is increased by raised intracellular camp in the intact rat heart via a CaMKII mediated pathway

Nisbet, A. M., Burton, F. L., Walker, N. L., Craig, M. A., Cheng, H., Hancox, J. C., Orchard, C. H., Smith, G. L. (2014) Acidosis slows electrical conduction through the atrio-ventricular node Frontiers in Physiology, 5, (doi: 10.3389/fphys.2014.00233)