Dr Caroline Muellenbroich

Senior Lecturer (School of Physics & Astronomy)

email: Caroline.Muellenbroich@glasgow.ac.uk
pronouns: She/her/hers

Advanced Research Centre, 11 Chaep Ln, University of Glasgow, United Kingdom, G11 6EW

Biography

I studied physics at the University of Heidelberg, Germany and obtained my PhD from the Institute of Photonics, University of Strathclyde, Glasgow in 2012 with a thesis on the application of adaptive optics in advanced microscopy techniques. I then joined the Biophotonics group at the European Laboratory for Nonlinear Spectroscopy (LENS) in Florence, Italy as a post doc in 2013 to implement confocal light-sheet microscopy for structural whole mouse brain imaging and then later functional calcium imaging in Zebrafish. From 2016 on, I was a researcher with the Italian National Institute of Optics, part of the Italian National Research Council. I joined the University of Glasgow in 2018 and am now a lecturer.

Research interests

Research groups

Imaging Concepts

Publications

List by: Type | Date

Jump to: 2026 | 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2011 | 2008

Number of items: 47.

2026

Moreno, Steven, Mohanan, Shakira, Elnageh, Ahmed, Boland, Erin, Williamson, Lewis, Olianti, Camilla, Sacconi, Leonardo, Smith, Godfrey ORCID: https://orcid.org/0000-0003-4821-9741, Huethorst, Eline ORCID: https://orcid.org/0000-0003-1900-4039 and Muellenbroich, Marie-Caroline ORCID: https://orcid.org/0000-0003-0113-8573 (2026) Mechanical de-skewing enables high-resolution imaging of thin tissue slices with a mesoSPIM light-sheet microscope. Biomedical Optics Express, 17(2), pp. 671-685. (doi: 10.1364/BOE.583082)

Millar, E. et al. (2026) Fluorescence-lifetime optical electrophysiology in contracting cardiomyocytes. bioRxiv, (doi: 10.64898/2026.01.12.699013)

2025

Dickinson, T. et al. (2025) Quantum-enhanced second harmonic generation beyond the photon pairs regime. Science Advances, 11(27), eadw4820. (doi: 10.1126/sciadv.adw4820) (PMID:40614189)

Abbasi, Q. ORCID: https://orcid.org/0000-0002-7097-9969, Ardao, S. Dopico, Forgan, R. ORCID: https://orcid.org/0000-0003-4767-6852, Gauchotte-Lindsay, C. ORCID: https://orcid.org/0000-0002-4970-5031, Lu, B., Todman, A., Watkins, P. and Muellenbroich, Caroline ORCID: https://orcid.org/0000-0003-0113-8573 (2025) Engineering Inclusive and Interdisciplinary Research Excellence: The DiveIn Approach to Diversity in Postgraduate Research. In: 2025 IEEE Conference on Education and Training in Optics and Photonics (ETOP), Glasgow, UK, 19-22 May 2025, ISBN 9798331543013 (doi: 10.1109/ETOP64842.2025.11030640)

Arecchi, G. et al. (2025) Probing relaxed myosin states in hypertrophic cardiomyopathy by second harmonic-generation microscopy. bioRxiv, (doi: 10.1101/2025.05.08.652664)

2024

Mohanan, Sharika ORCID: https://orcid.org/0000-0002-1364-0010, Horsell, David, Watters, Taylor, Ghasemi, Mohammadreza, Henderson, Lewis, Muellenbroich, Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Bub, Gil, Burton, Francis, Smith, Godfrey ORCID: https://orcid.org/0000-0003-4821-9741 and Corbett, Alexander D. (2024) Automated measurement of cardiomyocyte monolayer contraction using the Exeter Multiscope. bioRxiv, (doi: 10.1101/2024.09.09.611998)

Bueno, Gloria, Bowman, Richard, Simpson, Jeremy, Muellenbroich, Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Harvey, Andy ORCID: https://orcid.org/0000-0002-6825-1688, Taylor, Jonathan ORCID: https://orcid.org/0000-0001-7047-1789, Cristóbal, Gabriel, Deniz, Oscar, Gregory, G. Groot and Poulin-Girard, Anne-Sophie (2024) MICROSCOM: Erasmus Mundus Joint Master in Advanced Microscopy with Artificial Intelligence. In: SPIE Optical Engineering + Applications Conference 2024, San Diego, CA, USA, 18-23 Aug 2024, ISBN 9781510679177 (doi: 10.1117/12.3028150)

Bowman, Richard, Muellenbroich, Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Diederich, Benedict, McConnell, Gail, Faez, Sanli and Arancio, Julieta (2024) Open, reproducible hardware for microscopy. Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences, 382(2274), 20230112. (doi: 10.1098/rsta.2023.0112) (PMID:38826046)

Astrauskaite, Giedre, Mohanan, Sharika ORCID: https://orcid.org/0000-0002-1364-0010, Williamson, Lewis, Boland, Erin, Huethorst, Eline ORCID: https://orcid.org/0000-0003-1900-4039, Kinegawa, Ryo, Smith, Godfrey ORCID: https://orcid.org/0000-0003-4821-9741 and Muellenbroich, Caroline ORCID: https://orcid.org/0000-0003-0113-8573 (2024) Remote Focusing for 2-photon Microscopy to Follow Action Potential Propagation Transmurally in Acute Rabbit Cardiac Slices. In: SPIE BiOS 2024, San Francisco, CA, USA, 27 January - 1 February 2024, ISBN 9781510669536 (doi: 10.1117/12.3002956)

2023

Savchev, Yuliyan, Muellenbroich, Caroline ORCID: https://orcid.org/0000-0003-0113-8573 and Parreira, Pedro ORCID: https://orcid.org/0000-0003-4527-012X (2023) Approaches to Programming in 1st year Physics. LTCONF23: 16th Annual University of Glasgow Learning & Teaching Conference, Glasgow, UK; Online, 29 Mar - 13 Apr 2023.

Weir, Alix, Muellenbroich, Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Neilan, Claire and Parreira, Pedro Miguel ORCID: https://orcid.org/0000-0003-4527-012X (2023) Exploring the Limits of Teamwork through Task Splitting. LTCONF23: 16th Annual University of Glasgow Learning & Teaching Conference, Glasgow, UK; Online, 29 Mar - 13 Apr 2023.

2022

Diederich, Benedict, Müllenbroich, Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Vladimirov, Nikita, Bowman, Richard, Stirling, Julian, Reynaud, Emmanuel G. and Andreev, Andrey (2022) CAD we share? Publishing reproducible microscope hardware. Nature Methods, 19(9), pp. 1026-1030. (doi: 10.1038/s41592-022-01484-5) (PMID:35508735)

de Vito, G. et al. (2022) Fast whole-brain imaging of seizures in zebrafish larvae by two-photon light-sheet microscopy. Biomedical Optics Express, 13(3), pp. 1516-1536. (doi: 10.1364/BOE.434146) (PMID:35414999) (PMCID:PMC8973167)

Ricci, Pietro, Gavryusev, Vladislav, Müllenbroich, Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Turrini, Lapo, de Vito, Giuseppe, Silvestri, Ludovico, Sancataldo, Giuseppe and Pavone, Francesco Saverio (2022) Removing striping artifacts in light-sheet fluorescence microscopy: a review. Progress in Biophysics and Molecular Biology, 168, pp. 52-65. (doi: 10.1016/j.pbiomolbio.2021.07.003) (PMID:34274370)

2021

Müllenbroich, M. C. et al. (2021) Novel optics-based approaches for cardiac electrophysiology: a review. Frontiers in Physiology, 12, 769586. (doi: 10.3389/fphys.2021.769586) (PMID:34867476) (PMCID:PMC8637189)

Silvestri, L. et al. (2021) Universal autofocus for quantitative volumetric microscopy of whole mouse brains. Nature Methods, 18(8), pp. 953-958. (doi: 10.1038/s41592-021-01208-1) (PMID:34312564)

Starrs, Liam, Croke, Sarah ORCID: https://orcid.org/0000-0003-4120-4133 and Muellenbroich, Caroline ORCID: https://orcid.org/0000-0003-0113-8573 (2021) Colonialism and Science. Project Report. N/A. (Unpublished)

2020

de Vito, G. et al. (2020) Two-photon high-speed light-sheet volumetric imaging of brain activity during sleep in zebrafish larvae. In: SPIE BiOS, 2020, San Francisco, California, United States, 1-6 Feb 2020, p. 1122604. ISBN 9781510632158 (doi: 10.1117/12.2542285)

de Vito, Giuseppe, Ricci, Pietro, Turrini, Lapo, Gavryusev, Vladislav, Müllenbroich, Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Tiso, Natascia, Vanzi, Francesco, Silvestri, Ludovico and Saverio Pavone, Francesco (2020) Effects of excitation light polarization on fluorescence emission in two-photon light-sheet microscopy. Biomedical Optics Express, 11(8), pp. 4651-4665. (doi: 10.1364/BOE.396388) (PMID:32923069) (PMCID:PMC7449752)

Ricci, Pietro, Sancataldo, Giuseppe, Gavryusev, Vladislav, Franceschini, Alessandra, Müllenbroich, Marie Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Silvestri, Ludovico and Pavone, Francesco Saverio (2020) Fast multi-directional DSLM for confocal detection without striping artifacts. Biomedical Optics Express, 11(6), pp. 3111-3124. (doi: 10.1364/BOE.390916) (PMID:32637245) (PMCID:PMC7316030)

2019

Di Giovanna, Antonino Paolo, Credi, Caterina, Franceschini, Alessandra, Müllenbroich, Marie Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Silvestri, Ludovico and Pavone, Francesco (2019) Tailored sample mounting for light-sheet fluorescence microscopy of clarified specimens by polydimethylsiloxane casting. Frontiers in Neuroanatomy, 13, 35. (doi: 10.3389/fnana.2019.00035)

2018

Müllenbroich, M. Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Silvestri, Ludovico, Di Giovanna, Antonino P., Mazzamuto, Giacomo, Costantini, Irene, Sacconi, Leonardo and Pavone, Francesco S. (2018) High-fidelity imaging in brain-wide structural studies using light-sheet microscopy. eNeuro, 5(6), e0124-18.2018. (doi: 10.1523/ENEURO.0124-18.2018)

Muellenbroich, M. Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Turrini, Lapo, Silvestri, Ludovico, Alterini, Tommaso, Gheisari, Ali, Vanzi, Francesco, Sacconi, Leonardo and Pavone, Francesco S. (2018) Bessel beam illumination reduces random and systematic errors in quantitative functional studies using light-sheet microscopy. Frontiers in Cellular Neuroscience, 12, 315. (doi: 10.3389/fncel.2018.00315) (PMID:30294262) (PMCID:PMC6158350)

Scardigli, M. et al. (2018) Real-time optical manipulation of cardiac conduction in intact hearts. Journal of Physiology, 596(17), pp. 3841-3858. (doi: 10.1113/jp276283) (PMID:29989169)

Di Giovanna, Antonino Paolo, Tibo, Alessandro, Silvestri, Ludovico, Müllenbroich, Marie Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Costantini, Irene, Allegra Mascaro, Anna Letizia, Sacconi, Leonardo, Frasconi, Paolo and Pavone, Francesco Saverio (2018) Whole-brain vasculature reconstruction at the single capillary level. Scientific Reports, 8, 12573. (doi: 10.1038/s41598-018-30533-3) (PMID:30135559) (PMCID:PMC6105658)

Pavone, Francesco Saverio, Sacconi, Leonardo, Silvestri, Ludovico, Alfieri, Domenico, Di Giovanna, Antonino Paolo, Müllenbroich, Marie Caroline ORCID: https://orcid.org/0000-0003-0113-8573 and Adam, Marie-Pierre (2018) Confocal multispot microscope for fast and deep imaging in semicleared tissues. Journal of Biomedical Optics, 23(2), 020503. (doi: 10.1117/1.JBO.23.2.020503) (PMID:29460510)

2017

Turrini, L. et al. (2017) Optical mapping of neuronal activity during seizures in zebrafish. Scientific Reports, 7, 3025. (doi: 10.1038/s41598-017-03087-z) (PMID:28596596) (PMCID:PMC5465210)

Luo, Q. et al. (2017) High-fidelity Functional and Structural Whole-brain Imaging with Bessel-beam Light-sheet Microscopy (Conference presentation). SPIE BiOS 2017, San Francisco, CA., April 2017. 100510F. (doi: 10.1117/12.2251471)

Beaurepaire, E. et al. (2017) Optimal staining and clearing protocol for whole mouse brain vasculature imaging with light-sheet microscopy. European Conference on Biomedical Optics 2017, Munich, Germany, 25–29 June 2017. 104140N. ISBN 9781510612860 (doi: 10.1117/12.2285044)

Müllenbroich, M. Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Silvestri, Ludovico, Turrini, Lapo, Di Giovanna, Antonino Paolo, Alterini, Tommaso, Gheisari, Ali, Sacconi, Leonardo, vanzi, francesco and Pavone, Francesco S. (2017) High-Fidelity Imaging with Bessel-Beam Light-Sheet Microscopy for Whole-Brain Structural and Functional Studies. Optics and the Brain 2017, San Diego, CA., 2-5 April 2017. BrW4B.2. ISBN 9781943580255 (doi: 10.1364/BRAIN.2017.BrW4B.2)

Silvestri, Ludovico, Müllenbroich, Marie Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Costantini, Irene, Di Giovanna, Antonino Paolo, Sacconi, Leonardo and Pavone, Francesco S. (2017) Fast, Image-based Autofocus System for High-resolution Optical Microscopy of Whole Mouse Brains. Bio-Optics Design and Application 2017, San Diego, CA., 2-5 April 2017. JTu4A.8. ISBN 9781943580255 (doi: 10.1364/BODA.2017.JTu4A.8)

2016

Turrini, L., Alterini, T., Müllenbroich, C. ORCID: https://orcid.org/0000-0003-0113-8573, Gheisari, A., Sacconi, L., Silvestri, L., Vanzi, F. and Pavone, F.S. (2016) Functional Imaging of Zebrafish Neuronal Activity by Bessel Beam Light-Sheet Microscopy. In: 18th Italian National Conference on Photonic Technologies (Fotonica 2016), Rome, Italy, 6-8 June 2016, 66 (3 .)-66 (3 .). ISBN 9781785612688 (doi: 10.1049/cp.2016.0926)

Silvestri, Ludovico, Rudinskiy, Nikita, Paciscopi, Marco, Müllenbroich, Marie Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Costantini, Irene, Sacconi, Leonardo, Frasconi, Paolo, Hyman, Bradley T. and Pavone, Francesco S. (2016) Mapping Whole-Brain Activity with Cellular Resolution by Light-Sheet Microscopy and High-Throughput Image Analysis (Conference Presentation). Clinical and Translational Neurophotonics; Neural Imaging and Sensing; and Optogenetics and Optical Manipulation 2016, San Francisco, CA. p. 969012. (doi: 10.1117/12.2208603)

Di Giovanna, Antonino Paolo, Silvestri, Ludovico, Müllenbroich, Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Mascaro, Anna Letizia Allegra, Sacconi, Leonardo and Pavone, Francesco Saverio (2016) High-Resolution Reconstruction of Whole Mouse Brain Vasculature with Light-Sheet Microscopy. In: Optics and the Brain. Biomedical Optics 2016, Fort Lauderdale, FL., 25-28 Apr 2016, BTu4D.4. ISBN 9781943580101 (doi: 10.1364/brain.2016.btu4d.4)

2015

Müllenbroich, M. Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Silvestri, Ludovico, Onofri, Leonardo, Costantini, Irene, van’t Hoff, Marcel, Sacconi, Leonardo, Iannello, Giulio and Pavone, Francesco S. (2015) Comprehensive optical and data management infrastructure for high-throughput light-sheet microscopy of whole mouse brains. Neurophotonics, 2(4), 041404. (doi: 10.1117/1.NPh.2.4.041404) (PMID:26158018) (PMCID:PMC4484248)

Costantini, Irene, Giovanna, Antonino Paolo Di, Mascaro, Anna Letizia Allegra, Silvestri, Ludovico, Müllenbroich, Marie Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Sacconi, Leonardo and Pavone, Francesco S. (2015) A Versatile New Technique to Clear Mouse and Human Brain. In: European Conference on Biomedical Optics 2015, Munich, Germany, 21–25 June 2015, 95360X. ISBN 9781628417012 (doi: 10.1364/ecbo.2015.95360x)

Costantini, I. et al. (2015) A versatile clearing agent for multi-modal brain imaging. Scientific Reports, 5, 9808. (doi: 10.1038/srep09808) (PMID:25950610) (PMCID:PMC4423470)

Costantini, Irene, Allegra Mascaro, Anna Letizia, Di Giovanna, Antonino P., Silvestri, Ludovico, Müllenbroich, Marie Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Sacconi, Leonardo and Pavone, Francesco S. (2015) A multi modal clearing method for brain imaging. Optics and the Brain 2015, Vancouver, Canada, 12-15 April 2015. BrM3B.2. ISBN 9781557529541 (doi: 10.1364/BRAIN.2015.BrM3B.2)

Costantini, Irene, Di Giovanna, Antonino Paolo, Allegra Mascaro, Anna Letizia, Silvestri, Ludovico, Müllenbroich, Marie Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Sacconi, Leonardo and Pavone, Francesco S. (2015) A new versatile clearing method for brain imaging. In: Hirschberg, H., Madsen, S.J., Jansen, E.D., Luo, Q., Mohanty, S.K. and Thakor, N.V. (eds.) Optical Techniques in Neurosurgery, Neurophotonics, and Optogenetics II. Series: Proceedings of SPIE (9305). SPIE, p. 930514. ISBN 9781628413953 (doi: 10.1117/12.2076908)

Costantini, Irene, Di Giovanna, Antonino Paolo, Allegra Mascaro, Anna Letizia, Silvestri, Ludovico, Müllenbroich, Marie Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Sacconi, Leonardo and Pavone, Francesco S. (2015) A versatile new technique to clear mouse and human brain. In: Beaurepaire, E., So, P.T.C., Pavone, F. and Hillman, E.M. (eds.) Advanced Microscopy Techniques IV; and Neurophotonics II. Series: Proceedings of SPIE (9536). SPIE. ISBN 9781628417012 (doi: 10.1117/12.2184289)

Silvestri, Ludovico, Rudinskiy, Nikita, Paciscopi, Marco, Müllenbroich, Marie Caroline ORCID: https://orcid.org/0000-0003-0113-8573, Costantini, Irene, Sacconi, Leonardo, Frasconi, Paolo, hyman, Bradley T. and Pavone, Francesco S. (2015) Brain-wide charting of neuronal activation maps with cellular resolution. In: Optics and the Brain 2015, Vancouver, Canada, 12-15 April 2015, BrM3B.6. ISBN 9781557529541 (doi: 10.1364/BRAIN.2015.BrM3B.6)

2014

Müllenbroich, M. Caroline ORCID: https://orcid.org/0000-0003-0113-8573, McGhee, Ewan J., Wright, Amanda J., Anderson, Kurt I. and Mathieson, Keith (2014) Strategies to overcome photobleaching in algorithm-based adaptive optics for nonlinearin-vivoimaging. Journal of Biomedical Optics, 19(1), 016021. (doi: 10.1117/1.JBO.19.1.016021)

2013

Gramatikov, Boris, Irsch, Kristina, Müllenbroich, Marie ORCID: https://orcid.org/0000-0003-0113-8573, Frindt, Nicole, Qu, Yinhong, Gutmark, Ron, Wu, Yi-Kai and Guyton, David (2013) A device for continuous monitoring of true central fixation based on foveal birefringence. Annals of Biomedical Engineering, 41(9), pp. 1968-1978. (doi: 10.1007/s10439-013-0818-2) (PMID:23645511)

Müllenbroich, M.C. ORCID: https://orcid.org/0000-0003-0113-8573, McAlinden, N. and Wright, A.J. (2013) Adaptive optics in an optical trapping system for enhanced lateral trap stiffness at depth. Journal of Optics, 15(7), 075305. (doi: 10.1088/2040-8978/15/7/075305)

Müllenbroich, M. Caroline ORCID: https://orcid.org/0000-0003-0113-8573, McGhee, Ewan J., Wright, Amanda J., Anderson, Kurt I. and Mathieson, Keith (2013) Adaptive nonlinear microscopy for whole tissue imaging. In: Ammasi, P., Konig, K. and So, P.T.C. (eds.) Multiphoton Microscopy in the Biomedical Sciences XIII. Series: SPIE proceedings (8588). SPIE. ISBN 9780819493576 (doi: 10.1117/12.2006375)

2011

Muellenbroich, Caroline ORCID: https://orcid.org/0000-0003-0113-8573, McAlinden, Niall and Wright, Amanda J. (2011) Aberration Correction in an Optical Trapping System Using a Deformable Membrane Mirror. In: Frontiers in Optics 2011/Laser Science XXVII, San Jose, California, 16-20 Oct 2011, FTuS5. ISBN 9781557529176 (doi: 10.1364/FIO.2011.FTuS5)

2008

Ramey, Nicholas A., Ying, Howard S., Irsch, Kristina, Müllenbroich, Marie C. ORCID: https://orcid.org/0000-0003-0113-8573, Vaswani, Reena and Guyton, David L. (2008) A novel haploscopic viewing apparatus with a three-axis eye tracker. Journal of American Association for Pediatric Ophthalmology and Strabismus, 12(5), pp. 498-503. (doi: 10.1016/j.jaapos.2008.01.019) (PMID:18440260)

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