Dr David France

  • Senior Lecturer (School of Chemistry)

telephone: 01413307403
email: David.France@glasgow.ac.uk

Chemistry, Joseph Black Building, University Ave, Glasgow G12 8QQ

ORCID iDhttps://orcid.org/0000-0002-5409-3316

Biography

David was raised in the U.S. state of Ohio, and received his undergraduate degree in 2002 from The Ohio State University. While at Ohio State, David developed an interest in organic chemistry (mainly because it seemed to involve less maths than other fields) and conducted undergraduate research under the guidance of Prof. Leo Paquette. Upon graduation, David decided to check out Southern California, where he carried out his graduate research with Prof. Larry Overman at the University of California, Irvine. After completing his PhD in 2008, David moved to a rather older institution, the University of Cambridge, where he undertook a post-doctoral stay with Prof. Steve Ley. In 2010, David began his independent academic career at the University of Glasgow, where he is currently a Senior Lecturer.

 

    

Research interests

We’re interested in all the ways that carbon-based molecules can be useful to people. Often this leads us to interdisciplinary collaboration, for example with biologists to think about new ways to treat a disease. Specific active collaborations we have include:

Thinking about new ways to treat viral infections (like Covid-19) with Prof. Sam Wilson at the Centre for Virus Research.
 
Working with Profs. Laura Machesky and Justin Bower at the Beatson Institute for Cancer Research to stop cancer cell metastasis.

Developing new ways to influence stem cell differentiation with Prof. Matt Dalby.
 
Addressing the challenge of anti-microbial resistance with Prof. Andrew Roe, and Dr. Jesko Köhnke.  

Testing a new strategy that could be used to treat heart failure with Prof. Will Fuller.

Studying historical textile dyes for identification and preservation with Dr. Anita Quye.

Investigating ways to overcome drug resistance in parasitic nematodes with Prof. Tony Page

Research units

Publications

List by: Type | Date

Jump to: 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2011 | 2010
Number of items: 24.

2021

Hodgkinson, T. et al. (2021) The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells. Science Advances, 7(9), eabb7921. (doi: 10.1126/sciadv.abb7921) (PMID:33637520) (PMCID:PMC7909882)

Ruddell, S., Sugrue, E. , Memarzadeh, S., Hellam, L. M., Wilson, S. and France, D. (2021) Synthesis, enantiomeric resolution and biological evaluation of HIV capsid inhibition activity for racemic, (S)- and (R)-PF74. Molecules, 26(13), 3919. (doi: 10.3390/molecules26133919) (PMID:34206893) (PMCID:PMC8272108)

2020

Phillips, D. , Brodie, G., Memarzadeh, S., Tang, G. L. and France, D. J. (2020) MIDA boronate allylation – synthesis of ibuprofen. RSC Advances, 10(51), pp. 30624-30630. (doi: 10.1039/D0RA03338C)

2019

Wertz, J. H. , Quye, A. and France, D. (2019) Turkey red prints: Identification of lead chromate, Prussian blue and logwood on Turkey red calico. Conservar Património: Studies in Historical Textiles, 31, pp. 31-39. (doi: 10.14568/cp2018019)

2018

Smith, C. D., Phillips, D. , Tirla, A. and France, D. J. (2018) Catalytic isohypsic-redox sequences for the rapid generation of Csp3-containing heterocycles. Chemistry: A European Journal, 24(65), pp. 17201-17204. (doi: 10.1002/chem.201804131) (PMID:30203869) (PMCID:PMC6391974)

Wertz, J. H. , Tang, P. L., Quye, A. and France, D. (2018) Characterisation of oil and aluminium complex on replica and historical 19th c. Turkey red textiles by non-destructive diffuse reflectance FTIR spectroscopy. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 204, pp. 267-275. (doi: 10.1016/j.saa.2018.05.109) (PMID:29936224)

Wertz, J. H. , France, D. J. and Quye, A. (2018) Spectroscopic analysis of Turkey red oil samples as a basis for understanding historical dyed textiles. Coloration Technology, 134(5), pp. 319-325. (doi: 10.1111/cote.12343)

Phillips, D., Hewitt, J. F.M. and France, D. (2018) Synthesis of 3,3-disubstituted heterocycles by Pd-catalyzed arylallylation of unactivated alkenes. ACS Omega, 3(7), pp. 8451-8459. (doi: 10.1021/acsomega.8b01021)

2017

Reichenbach, J., Ruddell, S. A., González-Jiménez, M. , Lemes, J., Turton, D. A., France, D. J. and Wynne, K. (2017) Phonon-like hydrogen-bond modes in protic ionic liquids. Journal of the American Chemical Society, 139(21), pp. 7160-7163. (doi: 10.1021/jacs.7b03036) (PMID:28511538)

Phillips, D. and France, D. J. (2017) Palladium-catalysed heterocyclisation: a carbon-centred approach. Asian Journal of Organic Chemistry, 6(1), pp. 27-40. (doi: 10.1002/ajoc.201600410)

Wertz, J. H. , Quye, A. and France, D. (2017) Taking historical chemistry to the bench: A new perspective for modern chemists through the re-creation and analysis of 19th-century Scottish Turkey red dyed textiles. Mitteilungen: Gesellschaft Deutscher Chemiker, 25, pp. 302-328.

Wertz, J. H. , Quye, A. , France, D. , Tang, P. L. and Richmond, L. (2017) Authenticating Turkey Red Textiles through Material Investigations by FTIR and UHPLC. In: ICOM-CC 18th Triennial Meeting, Copenhagen, Denmark, 4-8 Sept 2017,

2016

Wertz, J.H. , Quye, A. and France, D. (2016) Natural or Synthetic? The Identification of Anthraquinone Dyes on Historical Turkey Red by UHPLC-PDA Analysis. 35th Annual Meeting of Dyes in History and Archaeology (DHA35), Pisa, Italy, 05-08 Oct 2016.

2015

France, D. J. , Stepek, G., Houston, D. R., Williams, L., McCormack, G., Walkinshaw, M. D. and Page, A. P. (2015) Identification and activity of inhibitors of the essential nematode-specific metalloprotease DPY-31. Bioorganic and Medicinal Chemistry Letters, (doi: 10.1016/j.bmcl.2015.10.077) (PMID:26546217) (PMCID:PMC4658336)

2014

Smith, C. D. and France, D. (2014) 2-Alkenyl furans from a palladium-catalyzed cyclization and coupling of ene-yne-ketones. ChemCatChem, 6(3), pp. 711-712. (doi: 10.1002/cctc.201301050)

Wertz, J. H. , Quye, A. , France, D. and Richmond, L. (2014) Creation and Analysis of Synthetic Alizarin and Replication of Turkey Red. In: 33rd Annual Meeting of Dyes in History and Archaeology, University of Glasgow, Glasgow, UK, 29 Oct - 1 Nov 2014,

2013

Canham, S.M., France, D.J. and Overman, L.E. (2013) Total synthesis of (+)-Sieboldine A: Evolution of a pinacol-terminated cyclization strategy. Journal of Organic Chemistry, 78(1), pp. 9-34. (doi: 10.1021/jo300872y)

Hewitt, J.F.M., Williams, L., Aggarwal, P., Smith, C.D. and France, D.J. (2013) Palladium-catalyzed heteroallylation of unactivated alkenes – synthesis of citalopram. Chemical Science, 4, pp. 3538-3543. (doi: 10.1039/C3SC51222C)

Wertz, J. , Quye, A. , France, D. and Richmond, L. (2013) Resurrecting Turkey Red: Adapting an Historic Process for Modern Re-creation and Analysis. In: 32nd Annual meeting of Dyes in History and Archaeology, La Rochelle, France, 2-5 Oct 2013,

Wertz, J. , Quye, A. , France, D. and Richmond, L. (2013) Textile Dyeing in Late Nineteenth-Century Glasgow: Interpreting and Re-Creating the Dye Chemists’ Experiments from Lab to Manufacture. In: 9th International Conference of the History of Chemistry, Uppsala, Sweden, 22-24 Aug 2013,

2011

Oelke, A.J. et al. (2011) Total synthesis of chloptosin: a dimeric cyclohexapeptide. Chemistry: A European Journal, 17(15), pp. 4183-4194. (doi: 10.1002/chem.201003216)

Oelke, A.J., France, D. , Hofmann, T., Wuitschik, G. and Ley, S.V. (2011) Piperazic acid-containing natural products: isolation, biological relevance and total synthesis. Natural Product Reports, 28(8), pp. 1445-1471. (doi: 10.1039/c1np00041a)

2010

Oelke, A.J., France, D.J. , Hofmann, T., Wuitschik, G. and Ley, S.V. (2010) Total synthesis of chloptosin. Angewandte Chemie (International Edition), 49(35), pp. 6139-6142. (doi: 10.1002/anie.201002880)

Canham, S.M., France, D.J. and Overman, L.E. (2010) Total synthesis of (+)-sieboldine A. Journal of the American Chemical Society, 132, pp. 7876-7877. (doi: 10.1021/ja103666n)

This list was generated on Sat Oct 23 10:53:43 2021 BST.
Number of items: 24.

Articles

Hodgkinson, T. et al. (2021) The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells. Science Advances, 7(9), eabb7921. (doi: 10.1126/sciadv.abb7921) (PMID:33637520) (PMCID:PMC7909882)

Ruddell, S., Sugrue, E. , Memarzadeh, S., Hellam, L. M., Wilson, S. and France, D. (2021) Synthesis, enantiomeric resolution and biological evaluation of HIV capsid inhibition activity for racemic, (S)- and (R)-PF74. Molecules, 26(13), 3919. (doi: 10.3390/molecules26133919) (PMID:34206893) (PMCID:PMC8272108)

Phillips, D. , Brodie, G., Memarzadeh, S., Tang, G. L. and France, D. J. (2020) MIDA boronate allylation – synthesis of ibuprofen. RSC Advances, 10(51), pp. 30624-30630. (doi: 10.1039/D0RA03338C)

Wertz, J. H. , Quye, A. and France, D. (2019) Turkey red prints: Identification of lead chromate, Prussian blue and logwood on Turkey red calico. Conservar Património: Studies in Historical Textiles, 31, pp. 31-39. (doi: 10.14568/cp2018019)

Smith, C. D., Phillips, D. , Tirla, A. and France, D. J. (2018) Catalytic isohypsic-redox sequences for the rapid generation of Csp3-containing heterocycles. Chemistry: A European Journal, 24(65), pp. 17201-17204. (doi: 10.1002/chem.201804131) (PMID:30203869) (PMCID:PMC6391974)

Wertz, J. H. , Tang, P. L., Quye, A. and France, D. (2018) Characterisation of oil and aluminium complex on replica and historical 19th c. Turkey red textiles by non-destructive diffuse reflectance FTIR spectroscopy. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 204, pp. 267-275. (doi: 10.1016/j.saa.2018.05.109) (PMID:29936224)

Wertz, J. H. , France, D. J. and Quye, A. (2018) Spectroscopic analysis of Turkey red oil samples as a basis for understanding historical dyed textiles. Coloration Technology, 134(5), pp. 319-325. (doi: 10.1111/cote.12343)

Phillips, D., Hewitt, J. F.M. and France, D. (2018) Synthesis of 3,3-disubstituted heterocycles by Pd-catalyzed arylallylation of unactivated alkenes. ACS Omega, 3(7), pp. 8451-8459. (doi: 10.1021/acsomega.8b01021)

Reichenbach, J., Ruddell, S. A., González-Jiménez, M. , Lemes, J., Turton, D. A., France, D. J. and Wynne, K. (2017) Phonon-like hydrogen-bond modes in protic ionic liquids. Journal of the American Chemical Society, 139(21), pp. 7160-7163. (doi: 10.1021/jacs.7b03036) (PMID:28511538)

Phillips, D. and France, D. J. (2017) Palladium-catalysed heterocyclisation: a carbon-centred approach. Asian Journal of Organic Chemistry, 6(1), pp. 27-40. (doi: 10.1002/ajoc.201600410)

Wertz, J. H. , Quye, A. and France, D. (2017) Taking historical chemistry to the bench: A new perspective for modern chemists through the re-creation and analysis of 19th-century Scottish Turkey red dyed textiles. Mitteilungen: Gesellschaft Deutscher Chemiker, 25, pp. 302-328.

France, D. J. , Stepek, G., Houston, D. R., Williams, L., McCormack, G., Walkinshaw, M. D. and Page, A. P. (2015) Identification and activity of inhibitors of the essential nematode-specific metalloprotease DPY-31. Bioorganic and Medicinal Chemistry Letters, (doi: 10.1016/j.bmcl.2015.10.077) (PMID:26546217) (PMCID:PMC4658336)

Smith, C. D. and France, D. (2014) 2-Alkenyl furans from a palladium-catalyzed cyclization and coupling of ene-yne-ketones. ChemCatChem, 6(3), pp. 711-712. (doi: 10.1002/cctc.201301050)

Canham, S.M., France, D.J. and Overman, L.E. (2013) Total synthesis of (+)-Sieboldine A: Evolution of a pinacol-terminated cyclization strategy. Journal of Organic Chemistry, 78(1), pp. 9-34. (doi: 10.1021/jo300872y)

Hewitt, J.F.M., Williams, L., Aggarwal, P., Smith, C.D. and France, D.J. (2013) Palladium-catalyzed heteroallylation of unactivated alkenes – synthesis of citalopram. Chemical Science, 4, pp. 3538-3543. (doi: 10.1039/C3SC51222C)

Oelke, A.J. et al. (2011) Total synthesis of chloptosin: a dimeric cyclohexapeptide. Chemistry: A European Journal, 17(15), pp. 4183-4194. (doi: 10.1002/chem.201003216)

Oelke, A.J., France, D. , Hofmann, T., Wuitschik, G. and Ley, S.V. (2011) Piperazic acid-containing natural products: isolation, biological relevance and total synthesis. Natural Product Reports, 28(8), pp. 1445-1471. (doi: 10.1039/c1np00041a)

Oelke, A.J., France, D.J. , Hofmann, T., Wuitschik, G. and Ley, S.V. (2010) Total synthesis of chloptosin. Angewandte Chemie (International Edition), 49(35), pp. 6139-6142. (doi: 10.1002/anie.201002880)

Canham, S.M., France, D.J. and Overman, L.E. (2010) Total synthesis of (+)-sieboldine A. Journal of the American Chemical Society, 132, pp. 7876-7877. (doi: 10.1021/ja103666n)

Conference or Workshop Item

Wertz, J.H. , Quye, A. and France, D. (2016) Natural or Synthetic? The Identification of Anthraquinone Dyes on Historical Turkey Red by UHPLC-PDA Analysis. 35th Annual Meeting of Dyes in History and Archaeology (DHA35), Pisa, Italy, 05-08 Oct 2016.

Conference Proceedings

Wertz, J. H. , Quye, A. , France, D. , Tang, P. L. and Richmond, L. (2017) Authenticating Turkey Red Textiles through Material Investigations by FTIR and UHPLC. In: ICOM-CC 18th Triennial Meeting, Copenhagen, Denmark, 4-8 Sept 2017,

Wertz, J. H. , Quye, A. , France, D. and Richmond, L. (2014) Creation and Analysis of Synthetic Alizarin and Replication of Turkey Red. In: 33rd Annual Meeting of Dyes in History and Archaeology, University of Glasgow, Glasgow, UK, 29 Oct - 1 Nov 2014,

Wertz, J. , Quye, A. , France, D. and Richmond, L. (2013) Resurrecting Turkey Red: Adapting an Historic Process for Modern Re-creation and Analysis. In: 32nd Annual meeting of Dyes in History and Archaeology, La Rochelle, France, 2-5 Oct 2013,

Wertz, J. , Quye, A. , France, D. and Richmond, L. (2013) Textile Dyeing in Late Nineteenth-Century Glasgow: Interpreting and Re-Creating the Dye Chemists’ Experiments from Lab to Manufacture. In: 9th International Conference of the History of Chemistry, Uppsala, Sweden, 22-24 Aug 2013,

This list was generated on Sat Oct 23 10:53:43 2021 BST.

Grants

 

VIRTACs - Protein Degradation as an Anti-Viral Strategy
EPSRC (PI with Prof. Sam Wilson)
2021–2024

"Mapping and controlling nucleation"
EPSRC (CoI with Prof. Klaas Wynne)
2016–2019
 
"New Multiple Bond-Forming Strategies for Organic Synthesis"
EPSRC (PI)
2011–2013

 

“Aversion Therapy for Bacteria: Repurposing Aurodox”
MRC (CoI with Prof. Andrew Roe)
2021–2024

 


Investigation of Anthelmintic Drug Uptake and Resistance Mechanisms in Gastrointestinal Nematode Parasites of Livestock
BBSRC (CoI with Prof. Tony Page)
2018–2021

 


“Small molecule-induced protein degradation for the prevention of metastasis”
CRUK (PI with Prof. Laura Machesky and Prof. Justin Bower)
2017–2021

Supervision

 


That's 1m distancing, right?

 

Group members

 


Dr. Liam Martin

 


Sarah Memarzadeh 



Emily Gallen (with Prof. Will Fuller) 



Chara Dimitriadi Evgenidi


Lorna Mae Hellam


Charlotte Bryson


 
Katie McClure (with Dr. Anita Quye)

  • McClure, Kathryn Raeburn
    Developing an Analytical Protocol for Synthetic Organic Textile Dyes for Use in Cultural Heritage Studies