Dr David France
- Lecturer (School of Chemistry)
telephone:
01413307403
email:
David.France@glasgow.ac.uk
Chemistry, Joseph Black Building, University Ave, Glasgow G12 8QQ
https://orcid.org/0000-0002-5409-3316Research interests
Research Interests
Our research is grounded in the idea that molecules in isolation don’t serve any function, but that interactions with larger systems can generate important effects. The systems we’re most interested in are biological, and therefore carbon based, the original definition of the term “organic”.
The Chemistry we study has lots of different applications, which can be classified into three major themes (if you’re into labeling things):
Synthetic Strategy, which aims to change how scientists think about making new bioactive compounds
Analytics where the objective is to develop new Chemical tools to probe natural Biological systems
Medicinal Chemistry for which the goal is to make specific molecules to treat particular diseases. (We’re especially interested in treating parasitic worm infections.)
Research units
Publications
2021
Hodgkinson, T. et al. (2021) The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells. Science Advances, 7(9), eabb7921. (doi: 10.1126/sciadv.abb7921) (PMID:33637520) (PMCID:PMC7909882)
Ruddell, S., Sugrue, E. , Memarzadeh, S., Hellam, L. M., Wilson, S. and France, D. (2021) Synthesis, enantiomeric resolution and biological evaluation of HIV capsid inhibition activity for racemic, (S)- and (R)-PF74. Molecules, 26(13), 3919. (doi: 10.3390/molecules26133919) (PMID:34206893) (PMCID:PMC8272108)
2020
Phillips, D. , Brodie, G., Memarzadeh, S., Tang, G. L. and France, D. J. (2020) MIDA boronate allylation – synthesis of ibuprofen. RSC Advances, 10(51), pp. 30624-30630. (doi: 10.1039/D0RA03338C)
2019
Wertz, J. H. , Quye, A. and France, D. (2019) Turkey red prints: Identification of lead chromate, Prussian blue and logwood on Turkey red calico. Conservar Património: Studies in Historical Textiles, 31, pp. 31-39. (doi: 10.14568/cp2018019)
2018
Smith, C. D., Phillips, D. , Tirla, A. and France, D. J. (2018) Catalytic isohypsic-redox sequences for the rapid generation of Csp3-containing heterocycles. Chemistry: A European Journal, 24(65), pp. 17201-17204. (doi: 10.1002/chem.201804131) (PMID:30203869) (PMCID:PMC6391974)
Wertz, J. H. , Tang, P. L., Quye, A. and France, D. (2018) Characterisation of oil and aluminium complex on replica and historical 19th c. Turkey red textiles by non-destructive diffuse reflectance FTIR spectroscopy. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 204, pp. 267-275. (doi: 10.1016/j.saa.2018.05.109) (PMID:29936224)
Wertz, J. H. , France, D. J. and Quye, A. (2018) Spectroscopic analysis of Turkey red oil samples as a basis for understanding historical dyed textiles. Coloration Technology, 134(5), pp. 319-325. (doi: 10.1111/cote.12343)
Phillips, D., Hewitt, J. F.M. and France, D. (2018) Synthesis of 3,3-disubstituted heterocycles by Pd-catalyzed arylallylation of unactivated alkenes. ACS Omega, 3(7), pp. 8451-8459. (doi: 10.1021/acsomega.8b01021)
2017
Reichenbach, J., Ruddell, S. A., González-Jiménez, M. , Lemes, J., Turton, D. A., France, D. J. and Wynne, K. (2017) Phonon-like hydrogen-bond modes in protic ionic liquids. Journal of the American Chemical Society, 139(21), pp. 7160-7163. (doi: 10.1021/jacs.7b03036) (PMID:28511538)
Phillips, D. and France, D. J. (2017) Palladium-catalysed heterocyclisation: a carbon-centred approach. Asian Journal of Organic Chemistry, 6(1), pp. 27-40. (doi: 10.1002/ajoc.201600410)
Wertz, J. H. , Quye, A. and France, D. (2017) Taking historical chemistry to the bench: A new perspective for modern chemists through the re-creation and analysis of 19th-century Scottish Turkey red dyed textiles. Mitteilungen: Gesellschaft Deutscher Chemiker, 25, pp. 302-328.
Wertz, J. H. , Quye, A. , France, D. , Tang, P. L. and Richmond, L. (2017) Authenticating Turkey Red Textiles through Material Investigations by FTIR and UHPLC. In: ICOM-CC 18th Triennial Meeting, Copenhagen, Denmark, 4-8 Sept 2017,
2016
Wertz, J.H. , Quye, A. and France, D. (2016) Natural or Synthetic? The Identification of Anthraquinone Dyes on Historical Turkey Red by UHPLC-PDA Analysis. 35th Annual Meeting of Dyes in History and Archaeology (DHA35), Pisa, Italy, 05-08 Oct 2016.
2015
France, D. J. , Stepek, G., Houston, D. R., Williams, L., McCormack, G., Walkinshaw, M. D. and Page, A. P. (2015) Identification and activity of inhibitors of the essential nematode-specific metalloprotease DPY-31. Bioorganic and Medicinal Chemistry Letters, (doi: 10.1016/j.bmcl.2015.10.077) (PMID:26546217) (PMCID:PMC4658336)
2014
Smith, C. D. and France, D. (2014) 2-Alkenyl furans from a palladium-catalyzed cyclization and coupling of ene-yne-ketones. ChemCatChem, 6(3), pp. 711-712. (doi: 10.1002/cctc.201301050)
Wertz, J. H. , Quye, A. , France, D. and Richmond, L. (2014) Creation and Analysis of Synthetic Alizarin and Replication of Turkey Red. In: 33rd Annual Meeting of Dyes in History and Archaeology, University of Glasgow, Glasgow, UK, 29 Oct - 1 Nov 2014,
2013
Canham, S.M., France, D.J. and Overman, L.E. (2013) Total synthesis of (+)-Sieboldine A: Evolution of a pinacol-terminated cyclization strategy. Journal of Organic Chemistry, 78(1), pp. 9-34. (doi: 10.1021/jo300872y)
Hewitt, J.F.M., Williams, L., Aggarwal, P., Smith, C.D. and France, D.J. (2013) Palladium-catalyzed heteroallylation of unactivated alkenes – synthesis of citalopram. Chemical Science, 4, pp. 3538-3543. (doi: 10.1039/C3SC51222C)
Wertz, J. , Quye, A. , France, D. and Richmond, L. (2013) Resurrecting Turkey Red: Adapting an Historic Process for Modern Re-creation and Analysis. In: 32nd Annual meeting of Dyes in History and Archaeology, La Rochelle, France, 2-5 Oct 2013,
Wertz, J. , Quye, A. , France, D. and Richmond, L. (2013) Textile Dyeing in Late Nineteenth-Century Glasgow: Interpreting and Re-Creating the Dye Chemists’ Experiments from Lab to Manufacture. In: 9th International Conference of the History of Chemistry, Uppsala, Sweden, 22-24 Aug 2013,
2011
Oelke, A.J. et al. (2011) Total synthesis of chloptosin: a dimeric cyclohexapeptide. Chemistry: A European Journal, 17(15), pp. 4183-4194. (doi: 10.1002/chem.201003216)
Oelke, A.J., France, D. , Hofmann, T., Wuitschik, G. and Ley, S.V. (2011) Piperazic acid-containing natural products: isolation, biological relevance and total synthesis. Natural Product Reports, 28(8), pp. 1445-1471. (doi: 10.1039/c1np00041a)
2010
Oelke, A.J., France, D.J. , Hofmann, T., Wuitschik, G. and Ley, S.V. (2010) Total synthesis of chloptosin. Angewandte Chemie (International Edition), 49(35), pp. 6139-6142. (doi: 10.1002/anie.201002880)
Canham, S.M., France, D.J. and Overman, L.E. (2010) Total synthesis of (+)-sieboldine A. Journal of the American Chemical Society, 132, pp. 7876-7877. (doi: 10.1021/ja103666n)
Articles
Hodgkinson, T. et al. (2021) The use of nanovibration to discover specific and potent bioactive metabolites that stimulate osteogenic differentiation in mesenchymal stem cells. Science Advances, 7(9), eabb7921. (doi: 10.1126/sciadv.abb7921) (PMID:33637520) (PMCID:PMC7909882)
Ruddell, S., Sugrue, E. , Memarzadeh, S., Hellam, L. M., Wilson, S. and France, D. (2021) Synthesis, enantiomeric resolution and biological evaluation of HIV capsid inhibition activity for racemic, (S)- and (R)-PF74. Molecules, 26(13), 3919. (doi: 10.3390/molecules26133919) (PMID:34206893) (PMCID:PMC8272108)
Phillips, D. , Brodie, G., Memarzadeh, S., Tang, G. L. and France, D. J. (2020) MIDA boronate allylation – synthesis of ibuprofen. RSC Advances, 10(51), pp. 30624-30630. (doi: 10.1039/D0RA03338C)
Wertz, J. H. , Quye, A. and France, D. (2019) Turkey red prints: Identification of lead chromate, Prussian blue and logwood on Turkey red calico. Conservar Património: Studies in Historical Textiles, 31, pp. 31-39. (doi: 10.14568/cp2018019)
Smith, C. D., Phillips, D. , Tirla, A. and France, D. J. (2018) Catalytic isohypsic-redox sequences for the rapid generation of Csp3-containing heterocycles. Chemistry: A European Journal, 24(65), pp. 17201-17204. (doi: 10.1002/chem.201804131) (PMID:30203869) (PMCID:PMC6391974)
Wertz, J. H. , Tang, P. L., Quye, A. and France, D. (2018) Characterisation of oil and aluminium complex on replica and historical 19th c. Turkey red textiles by non-destructive diffuse reflectance FTIR spectroscopy. Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 204, pp. 267-275. (doi: 10.1016/j.saa.2018.05.109) (PMID:29936224)
Wertz, J. H. , France, D. J. and Quye, A. (2018) Spectroscopic analysis of Turkey red oil samples as a basis for understanding historical dyed textiles. Coloration Technology, 134(5), pp. 319-325. (doi: 10.1111/cote.12343)
Phillips, D., Hewitt, J. F.M. and France, D. (2018) Synthesis of 3,3-disubstituted heterocycles by Pd-catalyzed arylallylation of unactivated alkenes. ACS Omega, 3(7), pp. 8451-8459. (doi: 10.1021/acsomega.8b01021)
Reichenbach, J., Ruddell, S. A., González-Jiménez, M. , Lemes, J., Turton, D. A., France, D. J. and Wynne, K. (2017) Phonon-like hydrogen-bond modes in protic ionic liquids. Journal of the American Chemical Society, 139(21), pp. 7160-7163. (doi: 10.1021/jacs.7b03036) (PMID:28511538)
Phillips, D. and France, D. J. (2017) Palladium-catalysed heterocyclisation: a carbon-centred approach. Asian Journal of Organic Chemistry, 6(1), pp. 27-40. (doi: 10.1002/ajoc.201600410)
Wertz, J. H. , Quye, A. and France, D. (2017) Taking historical chemistry to the bench: A new perspective for modern chemists through the re-creation and analysis of 19th-century Scottish Turkey red dyed textiles. Mitteilungen: Gesellschaft Deutscher Chemiker, 25, pp. 302-328.
France, D. J. , Stepek, G., Houston, D. R., Williams, L., McCormack, G., Walkinshaw, M. D. and Page, A. P. (2015) Identification and activity of inhibitors of the essential nematode-specific metalloprotease DPY-31. Bioorganic and Medicinal Chemistry Letters, (doi: 10.1016/j.bmcl.2015.10.077) (PMID:26546217) (PMCID:PMC4658336)
Smith, C. D. and France, D. (2014) 2-Alkenyl furans from a palladium-catalyzed cyclization and coupling of ene-yne-ketones. ChemCatChem, 6(3), pp. 711-712. (doi: 10.1002/cctc.201301050)
Canham, S.M., France, D.J. and Overman, L.E. (2013) Total synthesis of (+)-Sieboldine A: Evolution of a pinacol-terminated cyclization strategy. Journal of Organic Chemistry, 78(1), pp. 9-34. (doi: 10.1021/jo300872y)
Hewitt, J.F.M., Williams, L., Aggarwal, P., Smith, C.D. and France, D.J. (2013) Palladium-catalyzed heteroallylation of unactivated alkenes – synthesis of citalopram. Chemical Science, 4, pp. 3538-3543. (doi: 10.1039/C3SC51222C)
Oelke, A.J. et al. (2011) Total synthesis of chloptosin: a dimeric cyclohexapeptide. Chemistry: A European Journal, 17(15), pp. 4183-4194. (doi: 10.1002/chem.201003216)
Oelke, A.J., France, D. , Hofmann, T., Wuitschik, G. and Ley, S.V. (2011) Piperazic acid-containing natural products: isolation, biological relevance and total synthesis. Natural Product Reports, 28(8), pp. 1445-1471. (doi: 10.1039/c1np00041a)
Oelke, A.J., France, D.J. , Hofmann, T., Wuitschik, G. and Ley, S.V. (2010) Total synthesis of chloptosin. Angewandte Chemie (International Edition), 49(35), pp. 6139-6142. (doi: 10.1002/anie.201002880)
Canham, S.M., France, D.J. and Overman, L.E. (2010) Total synthesis of (+)-sieboldine A. Journal of the American Chemical Society, 132, pp. 7876-7877. (doi: 10.1021/ja103666n)
Conference or Workshop Item
Wertz, J.H. , Quye, A. and France, D. (2016) Natural or Synthetic? The Identification of Anthraquinone Dyes on Historical Turkey Red by UHPLC-PDA Analysis. 35th Annual Meeting of Dyes in History and Archaeology (DHA35), Pisa, Italy, 05-08 Oct 2016.
Conference Proceedings
Wertz, J. H. , Quye, A. , France, D. , Tang, P. L. and Richmond, L. (2017) Authenticating Turkey Red Textiles through Material Investigations by FTIR and UHPLC. In: ICOM-CC 18th Triennial Meeting, Copenhagen, Denmark, 4-8 Sept 2017,
Wertz, J. H. , Quye, A. , France, D. and Richmond, L. (2014) Creation and Analysis of Synthetic Alizarin and Replication of Turkey Red. In: 33rd Annual Meeting of Dyes in History and Archaeology, University of Glasgow, Glasgow, UK, 29 Oct - 1 Nov 2014,
Wertz, J. , Quye, A. , France, D. and Richmond, L. (2013) Resurrecting Turkey Red: Adapting an Historic Process for Modern Re-creation and Analysis. In: 32nd Annual meeting of Dyes in History and Archaeology, La Rochelle, France, 2-5 Oct 2013,
Wertz, J. , Quye, A. , France, D. and Richmond, L. (2013) Textile Dyeing in Late Nineteenth-Century Glasgow: Interpreting and Re-Creating the Dye Chemists’ Experiments from Lab to Manufacture. In: 9th International Conference of the History of Chemistry, Uppsala, Sweden, 22-24 Aug 2013,
Grants
2016-2019 - EP/N007417/1 "Mapping and controlling nucleation" - £421k (CoI with Prof. Klaas Wynne)
2011-2013 - EP/I027165/1 "New Multiple Bond-Forming Strategies for Organic Synthesis" - £102k (PI)
Research datasets
2020
Hodgkinson, T., Tsimbouri, M. , Llopis-Hernandez, V. , Campsie, P., Scurr, D., Childs, P., Phillips, D. , Donnelly, S., Wells, J., Salmeron-Sanchez, M. , Burgess, K., Alexander, M., Vassalli, M. , Oreffo, R., Reid, S., France, D. and Dalby, M. (2020) Nanovibrational mesenchymal stem cell stimulation allows detection of highly osteo-specific bioactive metabolites that can be modified for enhanced potency. [Data Collection]
2018
Wertz, J. , France, D. and Quye, A. (2018) Characterisation of Turkey red oil by 1H and 13C NMR spectroscopy: Research on historical Turkey red dyeing for re-creation, conservation, and understanding. [Data Collection] (Unpublished)
