Systems Biology

Interdisciplinary approaches to understand biological systems.  




Kulkarni, J., Sahoo, S. A., Herzyk, P., Barvkar, V. T., Kumar, S. A., Ravichandran, J., Samal, A., Amtmann, A., Borde, M., Suprasanna, P., Srivastava, A. K. (2024) Early-responsive molecular signatures associated with halophytic adaptation in Sesuvium portulacastrum (L.) Plant, Cell and Environment, 47, pp. 961-975. (doi: 10.1111/pce.14767)

Blatt, M. R., Nguyen, T.-H. (2024) Surrounded by luxury: The necessities of subsidiary cells. Plant, Cell and Environment,

Busch, F. A., Ainsworth, E. A., Amtmann, A., Cavanagh, A. P., Driever, S. M., Ferguson, J. N., Kromdijk, J., Lawson, T., Leakey, A. D. B., Matthews, J. S. A., Meacham‐Hensold, K., Vath, R. L., Vialet‐Chabrand, S., Walker, B. J., Papanatsiou, M. (2024) A guide to photosynthetic gas exchange measurements: fundamental principles, best practice and potential pitfalls. Plant, Cell and Environment, (doi: 10.1111/pce.14815)

Harnett, M. M., Doonan, J., Tarafdar, A., Pineda, M., Duncombe-Moore, J., Buitrago, G., Pan, P., Hoskisson, P., Selman, C., Harnett, W. (2024) The parasitic worm product ES-62 protects against collagen-induced arthritis by resetting the gut-bone marrow axis in a microbiome-dependent manner. Frontiers in Tropical Diseases, 4, (doi: 10.3389/fitd.2023.1334705)

Baena, G., Xia, L., Waghmare, S., Yu, Z., Guo, Y., Blatt, M. R., Zhang, B., Karnik, R. (2024) Arabidopsis SNARE SYP132 impacts on PIP2;1 trafficking and function in salinity stress. Plant Journal, (doi: 10.1111/tpj.16649)

Blatt, M. R. (2024) A charged existence: a century of transmembrane ion transport in plants. Plant Physiology, (doi: 10.1093/plphys/kiad630)

Shahzad, Z., Tournaire‐Roux, C., Canut, M., Adamo, M., Roeder, J., Verdoucq, L., Martinière, A., Amtmann, A., Santoni, V., Grill, E., Loudet, O., Maurel, C. (2024) Protein kinase SnRK2. 4 is a key regulator of aquaporins and root hydraulics in Arabidopsis. Plant Journal, 117, pp. 264-279. (doi: 10.1111/tpj.16494)


Silva-Alvim, F. A.L., Alvim, J. C., Harvey, A., Blatt, M. R. (2023) Speedy stomata of a C4 plant correlate with enhanced K+ channel gating. Plant, Cell and Environment, (doi: 10.1111/pce.14775)

Zhang, J., Nirmala, J., Chen, S., Jost, M., Steuernagel, B., Karafiatova, M., Hewitt, T., Li, H., Edae, E., Sharma, K., Hoxha, S., Bhatt, D., Antoniou Kourounioti, R. L., Dodds, P., Wulff, B. B.H., Dolezel, J., Ayliffe, M., Hiebert, C., McIntosh, R., Dubcovsky, J., Zhang, P., Rouse, M. N., Lagudah, E. (2023) Single amino acid change alters specificity of the multi-allelic wheat stem rust resistance locus SR9. Nature Communications, 14, (doi: 10.1038/s41467-023-42747-9)

Nguyen, T.-H., Silva-Alvim, F. A. L., Hills, A., Blatt, M. R. (2023) OnGuard3e: a predictive, ecophysiology‐ready tool for gas exchange and photosynthesis research. Plant, Cell and Environment, 46, pp. 3644-3658. (doi: 10.1111/pce.14674)

Sannino, D. R., Dobson, A. J. (2023) Acetobacter pomorum in the Drosophila gut microbiota buffers against host metabolic impacts of dietary preservative formula and batch variation in dietary yeast. Applied and Environmental Microbiology, 89, (doi: 10.1128/aem.00165-23)

Dornan, A. J., Halberg, K. V., Beuter, L.-K., Davies, S. A., Dow, J. A.T. (2023) Compromised junctional integrity phenocopies age-dependent renal dysfunction in Drosophila Snakeskin mutants. Journal of Cell Science, 136, (doi: 10.1242/jcs.261118)

Madsen, M. A., Semerdzhiev, S., Twigg, J. D., Moss, C., Bavington, C. D., Amtmann, A. (2023) Environmental modulation of exopolysaccharide production in the cyanobacterium Synechocystis 6803. Applied Microbiology and Biotechnology, 107, pp. 6121-6134. (doi: 10.1007/s00253-023-12697-9)

Harris, C. J., Amtmann, A., Ton, J. (2023) Epigenetic processes in plant stress priming: open questions and new approaches. Current Opinion in Plant Biology, 75, (doi: 10.1016/j.pbi.2023.102432)

Dobson, A., Voigt, S., Kumpitsch, L., Langer, L., Voigt, E., Ibrahim, R., Dowling, D., Reinhardt, K. (2023) Mitonuclear interactions shape both direct and parental effects of diet on fitness, and involve a SNP in mitoribosomal 16s rRNA. PLoS Biology, 21, (doi: 10.1371/journal.pbio.3002218)

Perrella, G., Fasano, C., Donald, N. A., Daddiego, L., Fang, W., Martignago, D., Carr, C., Conti, L., Herzyk, P., Amtmann, A. (2023) Histone Deacetylase Complex 1 and Histone 1 epigenetically moderate stress responsiveness of Arabidopsis thaliana seedlings. New Phytologist, (doi: 10.1111/nph.19165)

Antoniou-Kourounioti, R. L., Meschichi, A., Reeck, S., Berry, S., Menon, G., Zhao, Y., Fozard, J., Holmes, T., Zhao, L., Wang, H., Hartley, M., Dean, C., Rosa, S., Howard, M. (2023) Integrating analog and digital modes of gene expression at Arabidopsis FLC. eLife, 12, (doi: 10.7554/elife.79743)

Nguyen, T. B.-A., Lefoulon, C., Nguyen, T.-H., Blatt, M. R., Carroll, W. (2023) Engineering stomata for enhanced carbon capture and water-use efficiency. Trends in Plant Science, (doi: 10.1016/j.tplants.2023.06.002)

Karnik, R., Blatt, M. R. (2023) Analyzing protein–protein interactions using the split-ubiquitin system. Humana Press

Auge, G., Hankofer, V., Groth, M., Antoniou-Kourounioti, R., Ratikainen, I., Lampei, C. (2023) Plant environmental memory: implications, mechanisms, and opportunities for plant scientists and beyond. AoB Plants, 15, (doi: 10.1093/aobpla/plad032)

Arora, S. et al. (2023) A wheat kinase and immune receptor form host-specificity barriers against the blast fungus. Nature Plants, 9, pp. 385-392. (doi: 10.1038/s41477-023-01357-5)

Cannone, G., Kompaniiets, D., Graham, S., White, M. F., Spagnolo, L. (2023) Structure of the Saccharolobus solfataricus type III-D CRISPR effector. Current Research in Structural Biology, 5, (doi: 10.1016/j.crstbi.2023.100098)

Benoit, J. B., McCluney, K. E., DeGennaro, M. J., Dow, J. A.T. (2023) Dehydration dynamics in terrestrial arthropods: from water sensing to trophic interactions. Annual Review of Entomology, 68, pp. 129-149. (doi: 10.1146/annurev-ento-120120-091609)

McInnes, K. J., van der Hooft, J. J.J., Sharma, A., Herzyk, P., Hundleby, P. A.C., Schoonbeek, H.-J., Amtmann, A., Ridout, C., Jenkins, G. I. (2023) Overexpression of Brassica napus COMT1 in Arabidopsis heightens UV-B-mediated resistance to Plutella xylostella herbivory. Photochemical and Photobiological Sciences, 22, pp. 2341-2356. (doi: 10.1007/s43630-023-00455-9)


Seale, M., Zhdanov, O., Soons, M. B., Cummins, C., Kroll, E., Blatt, M. R., Zare-Behtash, H., Busse, A., Mastropaolo, E., Bullock, J. M., Viola, I. M., Nakayama, N. (2022) Environmental morphing enables informed dispersal of the dandelion diaspore. eLife, 11, (doi: 10.7554/eLife.81962)

Martínez Corrales, G., Li, M., Svermova, T., Goncalves, A., Voicu, D., Dobson, A. J., Southall, T. D., Alic, N. (2022) Transcriptional memory of dFOXO activation in youth curtails later-life mortality through chromatin remodelling and Xbp1. Nature Aging, 2, pp. 1176-1190. (doi: 10.1038/s43587-022-00312-x)

Horaruang, W., Klejchová, M., Carroll, W., Silva-Alvim, F. A.L., Waghmare, S., Papanatsiou, M., Amtmann, A., Hills, A., Alvim, J. C., Blatt, M. R., Zhang, B. (2022) Engineering a K+ channel 'sensory antenna' enhances stomatal kinetics, water use efficiency and photosynthesis. Nature Plants, 8, pp. 1262-1274. (doi: 10.1038/s41477-022-01255-2)

Eshel, G., Duppen, N., Wang, G., Oh, D.‐H., Kazachkova, Y., Herzyk, P., Amtmann, A., Gordon, M., Chalifa‐Caspi, V., Oscar, M. A., Bar‐David, S., Marshall‐Colon, A., Dassanayake, M., Barak, S. (2022) Positive selection and heat‐response transcriptomes reveal adaptive features of the Brassicaceae desert model, Anastatica hierochuntica. New Phytologist, 236, pp. 1006-1026. (doi: 10.1111/nph.18411)

Hogrel, G., Guild, A., Graham, S., Rickman, H., Grüschow, S., Bertrand, Q., Spagnolo, L., White, M. F. (2022) Cyclic nucleotide-induced helical structure activates a TIR immune effector. Nature, 608, pp. 808-812. (doi: 10.1038/s41586-022-05070-9)

Dow, J. A.T., Simons, M., Romero, M. F. (2022) Drosophila melanogaster: a simple genetic model of kidney structure, function and disease. Nature Reviews Nephrology, 18, pp. 417-434. (doi: 10.1038/s41581-022-00561-4)

Xu, J., Liu, Y., Lib, H., Tarashansky, A. J., Kalicki, C. H., Hung, R.-J., Hua, Y., Comjean, A., Kolluru, S. S., Wang, B., Quake, S. R., Luo, L., McMahon, A. P., Dow, J. A.T., Perrimon, N. (2022) Transcriptional and functional motifs defining renal function revealed by single-nucleus RNA sequencing. Proceedings of the National Academy of Sciences of the United States of America, 119, (doi: 10.1073/pnas.2203179119)

Thu, N. B.A., Amtmann, A., Blatt, M. R., Nguyen, T.-H. (2022) Stomata under salt stress—what can mechanistic modeling tell us? Academic Press

Wang, Y., Pan, P., Khan, A., Çil, Ç., Pineda, M. A. (2022) Synovial fibroblast sialylation regulates cell migration and activation of inflammatory pathways in arthritogenesis. Frontiers in Immunology, 13, (doi: 10.3389/fimmu.2022.847581)

Li, H. et al. (2022) Fly Cell Atlas: A single-nucleus transcriptomic atlas of the adult fruit fly. Science, 375, (doi: 10.1126/science.abk2432)

Blatt, M. R., Jezek, M., Lew, V. L., Hills, A. (2022) What can mechanistic models tell us about guard cells, photosynthesis, and water use efficiency? Trends in Plant Science, 27, pp. 166-179. (doi: 10.1016/j.tplants.2021.08.010)

Wang, Y., Çil, Ç., Harnett, M. M., Pineda, M. A. (2022) Cytohesin-2/ARNO: a novel bridge between cell migration and immunoregulation in synovial fibroblasts. Frontiers in Immunology, 12, (doi: 10.3389/fimmu.2021.809896)

Krause, S. A., Overend, G., Dow, J. A.T., Leader, D. P. (2022) FlyAtlas 2 in 2022: enhancements to the Drosophila melanogaster expression atlas. Nucleic Acids Research, 50, pp. D1010-D1015. (doi: 10.1093/nar/gkab971)

Zhdanov, O., Blatt, M. R., Zare-Behtash, H., Busse, A. (2022) Unidirectional versus bidirectional brushing: simulating wind influence on Arabidopsis thaliana. Quantitative Plant Biology, 3, (doi: 10.1017/qpb.2021.14)


Blatt, M. (2021) Ae fond fareweel. Plant Physiology, 187, pp. 2341-2343. (doi: 10.1093/plphys/kiab467)

Corbet, M., Pineda, M. A., Yang, K., Tarafdar, A., McGrath, S., NakagawaI, R., Lumb, F. E., Suckling, C. J., Harnett, W., Harnett, M. M. (2021) Suppression of inflammatory arthritis by the parasitic worm product ES-62 is associated with epigenetic changes in synovial fibroblasts. PLoS Pathogens, 17, (doi: 10.1371/journal.ppat.1010069)

Dow, J. A.T., Krause, S. A., Herzyk, P. (2021) Updates on ion and water transport by the Malpighian tubule. Current Opinion in Insect Science, 47, pp. 31-37. (doi: 10.1016/j.cois.2021.02.018)

Bonfini, A., Dobson, A. J., Duneau, D., Revah, J., Liu, X., Houtz, P., Buchon, N. (2021) Multiscale analysis reveals that diet-dependent midgut plasticity emerges from alterations in both stem cell niche coupling and enterocyte size. eLife, 10, (doi: 10.7554/elife.64125)

Jezek, M., Silva-Alvim, F. A.L., Hills, A., Donald, N., Ishka, M. R., Shadbolt, J., He, B., Lawson, T., Harper, J. F., Wang, Y., Lew, V. L., Blatt, M. R. (2021) Guard cell endomembrane Ca2+-ATPases underpin a ‘carbon memory’ of photosynthetic assimilation that impacts on water-use efficiency. Nature Plants, 7, pp. 1301-1313. (doi: 10.1038/s41477-021-00966-2)

Lupo, F., Ingersoll, M. A., Pineda, M. (2021) The glycobiology of uropathogenic E. coli infection: the sweet and bitter role of sugars in urinary tract immunity. Immunology, 164, pp. 3-14. (doi: 10.1111/imm.13330)

Koyama, T., Terhzaz, S., Naseem, M. T., Nagy, S., Rewitz, K., Dow, J. A.T., Davies, S. A., Halberg, K. V. (2021) A nutrient-responsive hormonal circuit mediates an inter-tissue program regulating metabolic homeostasis in adult Drosophila. Nature Communications, 12, (doi: 10.1038/s41467-021-25445-2)

Zhao, Y., Zhu, P., Hepworth, J., Bloomer, R., Antoniou-Kourounioti, R. L., Doughty, J., Heckmann, A., Xu, C., Yang, H., Dean, C. (2021) Natural temperature fluctuations promote COOLAIR regulation of FLC. Genes and Development, 35, pp. 888-898. (doi: 10.1101/gad.348362.121)

Eaglesfield, R., Madsen, M. A., Sanyal, S., Reboud, J., Amtmann, A. (2021) Co-translational recruitment of ribosomes in minimal protocells recreates a translocon-independent mechanism of proteorhodopsin biogenesis. iScience, 24, (doi: 10.1016/j.isci.2021.102429)

van Beek, L., McClay, É., Patel, S., Schimpl, M., Spagnolo, L., Maia de Oliveira, T. (2021) PARP power: a structural perspective on PARP1, PARP2, and PARP3 in DNA damage repair and nucleosome remodelling. International Journal of Molecular Sciences, 22, (doi: 10.3390/ijms22105112)

Wang, Y., Khan, A., Antonopoulos, A., Bouché, L., Buckley, C. D., Filer, A., Raza, K., Ping-Li, K., Tolusso, B., Gremese, E., Kurowska-Stolarska, M., Alivernini, S., Dell, A., Haslam, S. M., Pineda, M. A. (2021) Loss of α2-6 sialylation promotes the transformation of synovial fibroblasts into a pro-inflammatory phenotype in arthritis. Nature Communications, 12, (doi: 10.1038/s41467-021-22365-z)

Klejchova, M., Silva-Alvim, F. A.L., Blatt, M. R., Alvim, J. C. (2021) Membrane voltage as a dynamic platform for spatio-temporal signalling, physiological and developmental regulation. Plant Physiology, 185, pp. 1523-1541. (doi: 10.1093/plphys/kiab032)

Lumb, F. E., Doonan, J., Corbet, M., Pineda, M. A., Harnett, M. M., Harnett, W. (2021) Development of Acanthocheilonema viteae in Meriones shawi : Absence of microfilariae and production of active ES‐62. Parasite Immunology, 43, (doi: 10.1111/pim.12803)

Zhdanov, O., Blatt, M. R., Zare-Behtash, H., Busse, A. (2021) Wind-evoked anemotropism affects the morphology and mechanical properties of Arabidopsis. Journal of Experimental Botany, 72, pp. 1906-1918. (doi: 10.1093/jxb/eraa541)

Antoniou-Kourounioti, R. L., Zhao, Y., Dean, C., Howard, M. (2021) Feeling every bit of winter - distributed temperature sensitivity in vernalization. Frontiers in Plant Science, 12, (doi: 10.3389/fpls.2021.628726)

Madsen, M. A., Hamilton, G., Herzyk, P., Amtmann, A. (2021) Environmental regulation of PndbA600, an auto-inducible promoter for two-stage industrial biotechnology in cyanobacteria. Frontiers in Bioengineering and Biotechnology, 8, (doi: 10.3389/fbioe.2020.619055)


Dornan, A.J., Halberg, K.A., Beuter, L.-K., Davies, S.-A., Dow, J.A.T. (2020) The septate junction protein Snakeskin is critical for epithelial barrier function and tissue homeostasis in the Malpighian tubules of adult Drosophila. bioRxiv, (doi: 10.1101/2020.12.14.422678)

Zhdanov, O., Blatt, M. R., Cammarano, A., Zare-Behtash, H., Busse, A. (2020) A new perspective on mechanical characterisation of Arabidopsis stems through vibration tests. Journal of the Mechanical Behavior of Biomedical Materials, 112, (doi: 10.1016/j.jmbbm.2020.104041)

Jarad, M., Antoniou-Kourounioti, R. L., Hepworth, J., Qüesta, J. I. (2020) Unique and contrasting effects of light and temperature cues on plant transcriptional programs. Transcription, 11, pp. 134-159. (doi: 10.1080/21541264.2020.1820299)

Hepworth, J., Antoniou-Kourounioti, R. L., Berggren, K., Selga, C., Tudor, E. H., Yates, B., Cox, D., Rose Collier Harris, B., Irwin, J. A., Howard, M., Säll, T., Holm, S., Dean, C. (2020) Natural variation in autumn expression is the major adaptive determinant distinguishing Arabidopsis FLC haplotypes. eLife, 9, (doi: 10.7554/eLife.57671)

Lefoulon, C., Boxall, S. F., Hartwell, J., Blatt, M. R. (2020) Crassulacean acid metabolism guard cell anion channel activity follows transcript abundance and is suppressed by apoplastic malate. New Phytologist, 227, pp. 1847-1857. (doi: 10.1111/nph.16640)

Larson, E. R., Ortmannová, J., Donald, N. A., Alvim, J., Blatt, M. R., Žárský, V. (2020) Synergy among exocyst and SNARE interactions identifies a functional hierarchy in secretion during vegetative growth. Plant Cell, 32, pp. 2951-2963. (doi: 10.1105/tpc.20.00280)

Jezek, M., Hills, A., Blatt, M. R., Lew, V. L. (2020) A constraint-relaxation-recovery mechanism for stomatal dynamics. Plant, Cell and Environment, 42, pp. 2399-2410. (doi: 10.1111/pce.13568)

Zhao, Y., Antoniou-Kourounioti, R. L., Calder, G., Dean, C., Howard, M. (2020) Temperature-dependent growth contributes to long-term cold sensing. Nature, 583, pp. 825-829. (doi: 10.1038/s41586-020-2485-4)

Rennie, M. L., Lemonidis, K., Arkinson, C., Chaugule, V. K., Clarke, M., Streetley, J., Spagnolo, L., Walden, H. (2020) Differential functions of FANCI and FANCD2 ubiquitination stabilize ID2 complex on DNA. EMBO Reports, 21, (doi: 10.15252/embr.202050133)

Flütsch, S., Wang, Y., Takemiya, A., Vialet-Chabrand, S. R., Klejchova, M., Nigro, A., Hills, A., Lawson, T., Blatt, M. R., Santelia, D. (2020) Guard cell starch degradation yields glucose for rapid stomatal opening in Arabidopsis. Plant Cell, 32, pp. 2325-2344. (doi: 10.1105/tpc.18.00802)

Klejchová, M., Hills, A., Blatt, M. R. (2020) Predicting the unexpected in stomatal gas exchange: not just an open-and-shut case. Biochemical Society Transactions, 48, pp. 881-889. (doi: 10.1042/BST20190632)

Woodling, N. S., Aleyakpo, B., Dyson, M. C., Minkley, L. J., Rajasingam, A., Dobson, A. J., Leung, K. H. C., Pomposova, S., Fuentealba, M., Alic, N., Partridge, L. (2020) The neuronal receptor tyrosine kinase Alk is a target for longevity. Aging Cell, 19, (doi: 10.1111/acel.13137)

Crowe, J., Lumb, F. E., Doonan, J., Broussard, M., Tarafdar, A., Pineda, M. A., Landabaso, C., Mulvey, L., Hoskisson, P. A., Babayan, S. A., Selman, C., Harnett, W., Harnett, M. (2020) The parasitic worm product ES-62 promotes health- and life-span in a high calorie diet-accelerated mouse model of ageing. PLoS Pathogens, 16, (doi: 10.1371/journal.ppat.1008391)

Yuan, M., Yuan, X.-j., Pineda, M., Liang, Z.-y., He, J., Sun, S.-w., Pan, T.-l., Li, K.-p. (2020) A comparative study between Chinese propolis and Brazilian green propolis: metabolite profile and bioactivity. Food and Function, 11, pp. 2368-2379. (doi: 10.1039/C9FO02051A)

Qüesta, J. I., Antoniou-Kourounioti, R. L., Rosa, S., Li, P., Duncan, S., Whittaker, C., Howard, M., Dean, C. (2020) Noncoding SNPs influence a distinct phase of Polycomb silencing to destabilize long-term epigenetic memory at Arabidopsis FLC. Genes and Development, 34, pp. 446-461. (doi: 10.1101/gad.333245.119)

Cohen, E., Sawyer, J. K., Peterson, N. G., Dow, J. A.T., Fox, D. T. (2020) Physiology, development, and disease modeling in the Drosophila excretory system. Genetics, 214, pp. 235-264. (doi: 10.1534/genetics.119.302289)

Cabrero, P., Terhzaz, S., Dornan, A. J., Ghimire, S., Holmes, H. L., Turin, D. R., Romero, M. F., Davies, S., Dow, J. A.T. (2020) Specialized stellate cells offer a privileged route for rapid water flux in Drosophila renal tubule. Proceedings of the National Academy of Sciences of the United States of America, 117, pp. 1779-1787. (doi: 10.1073/pnas.1915943117)

Shahzad, Z., Eaglesfield, R., Carr, C., Amtmann, A. (2020) Cryptic variation in RNA-directed DNA-methylation controls lateral root development when auxin signaling is perturbed. Nature Communications, 11, (doi: 10.1038/s41467-019-13927-3)

Visentin, S., Cannone, G., Doutch, J., Harris, G., Gleghorn, M. L., Clifton, L., Smith, B. O., Spagnolo, L. (2020) A multi-pronged approach to understanding the form and function of hStaufen protein. RNA, 26, pp. 265-277. (doi: 10.1261/rna.072595.119)

Horaruang, W., Hills, A., Blatt, M. R. (2020) Communication between the plasma membrane and tonoplast is an emergent property of ion transport. Plant Physiology, 182, pp. 1833-1835. (doi: 10.1104/pp.19.01485)


Waghmare, S., Lefoulon, C., Zhang, B., Lileikyte, E., Donald, N., Blatt, M. (2019) K+ channel and SEC11 binding exchange regulates SNARE assembly for secretory traffic. Plant Physiology, 181, pp. 1096-1113. (doi: 10.1104/pp.19.00919)

Zhdanov, O., Busse, A., Cammarano, A., Zare-Behtash, H., Blatt, M. (2019) Effect of Wind on Morphology and Mechanical Properties of Arabidopsis Thaliana.

Ghimire, S., Terhzaz, S., Cabrero, P., Romero, M. F., Davies, S., Dow, J. A.T. (2019) Targeted renal knockdown of Na+/H+ exchanger regulatory factor Sip1 produces uric acid nephrolithiasis in Drosophila. American Journal of Physiology: Renal Physiology, 317, pp. F930-F940. (doi: 10.1152/ajprenal.00551.2018)

Jurić, I., Hibberd, J. M., Blatt, M., Burroughs, N. J. (2019) Computational modelling predicts substantial carbon assimilation gains for C3 plants with a single-celled C4 biochemical pump. PLoS Computational Biology, 15, (doi: 10.1371/journal.pcbi.1007373)

Latham, B., Poyade, M., Finlay, C., Edmond, A., McVey, M. (2019) New tools in education: development and learning effectiveness of a computer application for use in a university biology curriculum. Springer Nature

Dobson, A. J., Boulton-McDonald, R., Houchou, L., Svermova, T., Ren, Z., Subrini, J., Vazquez-Prada, M., Hoti, M., Rodriguez-Lopez, M., Ibrahim, R., Gregoriou, A., Gkantiragas, A., Bähler, J., Ezcurra, M., Alic, N. (2019) Longevity is determined by ETS transcription factors in multiple tissues and diverse species. PLoS Genetics, 15, (doi: 10.1371/journal.pgen.1008212)

Alford, L., Marley, R., Dornan, A., Dow, J. A.T., Nachman, R. J., Davies, S. A. (2019) Desiccation, thermal stress and associated mortality in Drosophila fruit flies induced by neuropeptide analogue treatment. Journal of Pest Science, 92, pp. 1123-1137. (doi: 10.1007/s10340-019-01100-0)

Alford, L., Marley, R., Dornan, A., Pierre, J.-S., Dow, J. A.T., Nachman, R. J., Davies, S. A. (2019) Assessment of neuropeptide binding sites and the impact of biostable kinin and CAP2b analogue treatment on aphid (Myzus persicae and Macrosiphum rosae) stress tolerance. Pest Management Science, 75, pp. 1750-1759. (doi: 10.1002/ps.5372)

Zhang, B., Karnik, R., Alvim, J., Donald, N., Blatt, M. R. (2019) Dual sites for SEC11 on the SNARE SYP121 implicate a binding exchange during secretory traffic. Plant Physiology, 180, pp. 228-239. (doi: 10.1104/pp.18.01315)

Martinez Corrales, G., Cabrero, P., Dow, J. A.T., Terhzaz, S., Davies, S. (2019) Novel roles for GATAe in growth, maintenance and proliferation of cell populations in the Drosophila renal tubule. Development, 146, (doi: 10.1242/dev.178087)

Doonan, J., Tarafdar, A., Pineda, M. A., Lumb, F. E., Crowe, J., Khan, A. M., Hoskisson, P. A., Harnett, M. M., Harnett, W. (2019) The parasitic worm product ES-62 normalises the gut microbiota bone marrow axis in inflammatory arthritis. Nature Communications, 10, (doi: 10.1038/s41467-019-09361-0)

Papanatsiou, M., Petersen, J., Henderson, L., Wang, Y., Christie, J.M., Blatt, M.R. (2019) Optogenetic manipulation of stomatal kinetics improves carbon assimilation, water use, and growth. Science, 363, pp. 1456-1459. (doi: 10.1126/science.aaw0046)

Zhao, C. et al. (2019) Evolution of chloroplast retrograde signaling facilitates green plant adaptation to land. Proceedings of the National Academy of Sciences of the United States of America, 116, pp. 5015-5020. (doi: 10.1073/pnas.1812092116)

Liao, X., Zhang, B., Blatt, M. R., Jenkins, G. I. (2019) A FRET method for investigating dimer/monomer status and conformation of the UVR8 photoreceptor. Photochemical and Photobiological Sciences, 18, pp. 367-374. (doi: 10.1039/C8PP00489G)

Landry, G. M., Furrow, E., Holmes, H. L., Hirata, T., Kato, A., Williams, P., Strohmaier, K., Gallo, C. J. R., Chang, M., Pandey, M. K., Jiang, H., Bansal, A., Franz, M.-C., Montalbetti, N., Alexander, M. P., Cabrero, P., Dow, J. A.T., DeGrado, T. R., Romero, M. F. (2019) Cloning, function, and localization of human, canine, and Drosophila ZIP10 (SLC39A10), a Zn2+ transporter. American Journal of Physiology: Renal Physiology, 316, pp. F263-F273. (doi: 10.1152/ajprenal.00573.2017)

Dow, J. A.T., Halberg, K. A., Terhzaz, S., Davies, S. A. (2019) Drosophila as a model for neuroendocrine control of renal homeostasis. Wiley

Davies, S.-A., Cabrero, P., Marley, R., Martinez-Corrales, G., Ghimire, S., Dornan, A. J., Dow, J. A.T. (2019) Epithelial function in the Drosophila Malpighian tubule: an in vivo renal model. Humana Press


Antoniou-Kourounioti, R. L., Hepworth, J., Heckmann, A., Duncan, S., Qüesta, J., Rosa, S., Säll, T., Holm, S., Dean, C., Howard, M. (2018) Temperature sensing is distributed throughout the regulatory network that controls FLC epigenetic silencing in vernalization. Cell Systems, 7, pp. 643-655.e9. (doi: 10.1016/j.cels.2018.10.011)

Waghmare, S., Lileikyte, E., Karnik, R., Goodman, J. K., Blatt, M. R., Jones, A. M.E. (2018) SNAREs SYP121 and SYP122 mediate the secretion of distinct cargo subsets. Plant Physiology, 178, pp. 1679-1688. (doi: 10.1104/pp.18.00832)

Madsen, M. A., Semerdzhiev, S., Amtmann, A., Tonon, T. (2018) Engineering mannitol biosynthesis in Escherichia coli and Synechococcus sp. PCC 7002 using a green algal fusion protein. ACS Synthetic Biology, 7, pp. 2833-2840. (doi: 10.1021/acssynbio.8b00238)

Lefoulon, C., Waghmare, S., Karnik, R., Blatt, M. R. (2018) Gating control and K+ uptake by the KAT1 K+ channel leaveraged through membrane anchoring of the trafficking protein SYP121. Plant, Cell and Environment, 41, pp. 2668-2677. (doi: 10.1111/pce.13392)

Davis, J. L., Armengaud, P., Larson, T. R., Graham, I. A., White, P. J., Newton, A. C., Amtmann, A. (2018) Contrasting nutrient‐disease relationships: potassium gradients in barley leaves have opposite effects on two fungal pathogens with different sensitivities to jasmonic acid. Plant, Cell and Environment, 41, pp. 2357-2372. (doi: 10.1111/pce.13350)

Pandit, A. A., Ragionieri, L., Marley, R., Yeoh, J. G.C., Inward, D. J.G., Davies, S.-A., Predel, R., Dow, J. A.T. (2018) Coordinated RNA-Seq and peptidomics identify neuropeptides and G-protein coupled receptors (GPCRs) in the large pine weevil Hylobius abietis, a major forestry pest. Insect Biochemistry and Molecular Biology, 101, pp. 94-107. (doi: 10.1016/j.ibmb.2018.08.003)

Zhang, B., Karnik, R., Donald, N., Blatt, M. R. (2018) A GPI signal peptide-anchored split-ubiquitin (GPS) system for detecting soluble bait protein interactions at the membrane. Plant Physiology, 178, pp. 13-17. (doi: 10.1104/pp.18.00577)

Li, K., He, Z., Wang, X., Pineda, M., Chen, R., Liu, H., Ma, K., Shen, H., Wu, C., Huang, N., Pan, T., Liu, Y., Guo, J. (2018) Apigenin C-glycosides of Microcos paniculata protects lipopolysaccharide induced apoptosis and inflammation in acute lung injury through TLR4 signaling pathway. Free Radical Biology and Medicine, 124, pp. 163-175. (doi: 10.1016/j.freeradbiomed.2018.06.009)

Shahzad, Z., Kellermeier, F., Armstrong, E. M., Rogers, S., Lobet, G., Amtmann, A., Hills, A. (2018) EZ-Root-VIS: A software pipeline for the rapid analysis and visual reconstruction of root system architecture. Plant Physiology, 177, pp. 1368-1381. (doi: 10.1104/pp.18.00217)

Feroz, H., Ferlez, B., Lefoulon, C., Ren, T., Baker, C. S., Gajewski, J. P., Lugar, D. J., Gaudana, S. B., Butler, P. J., Hühn, J., Lamping, M., Parak, W. J., Hibberd, J. M., Kerfeld, C. A., Smirnoff, N., Blatt, M. R., Golbeck, J. H., Kumar, M. (2018) Light-driven chloride transport kinetics of halorhodopsin. Biophysical Journal, 115, pp. 353-360. (doi: 10.1016/j.bpj.2018.06.009)

Finlay, C. (2018) Keynote: Challenges to Student Success. Can Digital Approaches Help Overcome Them?

Zhdanov, O., Busse, A., Blatt, M., Zare-Behtash, H. (2018) A specialised wind tunnel for investigation of ecophysiological response of plants to wind.

Doonan, J., Lumb, F. E., Pineda, M. A., Tarafdar, A., Crowe, J., Khan, A. M., Suckling, C. J., Harnett, M. M., Harnett, W. (2018) Protection against arthritis by the parasitic worm product ES-62, and its drug-like small molecule analogues, is associated with inhibition of osteoclastogenesis. Frontiers in Immunology, 9, (doi: 10.3389/fimmu.2018.01016)

Blatt, M. R. (2018) Concepts and techniques in plant membrane physiology. John Wiley & Sons, Ltd

Amtmann, A., Armengaud, P., Volkov, V. (2018) Potassium nutrition and salt stress. John Wiley & Sons, Ltd

Blatt, M.R., Thiel, G. (2018) SNARE components and mechanisms of exocytosis in plants. John Wiley & Sons, Ltd

Dobson, A. J., He, X., Blanc, E., Bolukbasi, E., Feseha, Y., Yang, M., Piper, M. D.W. (2018) Tissue-specific transcriptome profiling of Drosophila reveals roles for GATA transcription factors in longevity by dietary restriction. npj Aging and Mechanisms of Disease, 4, (doi: 10.1038/s41514-018-0024-4)

Terhzaz, S., Alford, L., Yeoh, J. G.C., Marley, R., Dornan, A. J., Dow, J. A.T., Davies, S. A. (2018) Renal neuroendocrine control of desiccation and cold tolerance by Drosophila suzukii. Pest Management Science, 74, pp. 800-810. (doi: 10.1002/ps.4663)

Sannino, D. R., Dobson, A. J., Edwards, K., Angert, E. R., Buchon, N. (2018) The Drosophila melanogaster gut microbiota provisions thiamine to its host. mBio, 9, (doi: 10.1128/mBio.00155-18)

Hepworth, J., Antoniou-Kourounioti, R. L., Bloomer, R. H., Selga, C., Berggren, K., Cox, D., Collier Harris, B. R., Irwin, J. A., Holm, S., Säll, T., Howard, M., Dean, C. (2018) Absence of warmth permits epigenetic memory of winter in Arabidopsis. Nature Communications, 9, (doi: 10.1038/s41467-018-03065-7)

Pantin, F., Blatt, M. R. (2018) Stomatal response to humidity: blurring the boundary between active and passive movement. Plant Physiology, 176, pp. 485-488. (doi: 10.1104/pp.17.01699)


Filer, D., Thompson, M. A., Takhaveev, V., Dobson, A. J., Kotronaki, I., Green, J. W.M., Heinemann, M., Tullet, J. M.A., Alic, N. (2017) RNA polymerase III limits longevity downstream of TORC1. Nature, 552, pp. 263-267. (doi: 10.1038/nature25007)

Wang, Y., Hills, A., Vialet-Chabrand, S., Papanatsiou, M., Griffiths, H., Rogers, S., Lawson, T., Lew, V. L., Blatt, M. R. (2017) Unexpected connections between humidity and ion transport discovered using a model to bridge guard cell-to-leaf scales. Plant Cell, 29, pp. 2921-2939. (doi: 10.1105/tpc.17.00694)

Leader, D. P., Krause, S. A., Pandit, A., Davies, S. A., Dow, J. A.T. (2017) FlyAtlas 2: a new version of the Drosophila melanogaster expression atlas with RNA-Seq, miRNA-Seq and sex-specific data. Nucleic Acids Research, 46, pp. D809-D815. (doi: 10.1093/nar/gkx976)

Larson, E. R., Van Zelm, E., Roux, C., Marion-Poll, A., Blatt, M. R. (2017) Clathrin Heavy Chain subunits coordinate endo- and exocytic traffic and affect stomatal movement. Plant Physiology, 175, pp. 708-720. (doi: 10.1104/pp.17.00970)

Shahzad, Z., Amtmann, A. (2017) Food for thought: how nutrients regulate root system architecture. Current Opinion in Plant Biology, 39, pp. 80-87. (doi: 10.1016/j.pbi.2017.06.008)

Dow, J. A.T. (2017) The essential roles of metal ions in insect homeostasis and physiology. Current Opinion in Insect Science, 23, pp. 43-50. (doi: 10.1016/j.cois.2017.07.001)

Yeoh, J. G.C., Pandit, A. A., Zandawala, M., Nässel, D. R., Davies, S.-A., Dow, J. (2017) DINeR: Database for Insect Neuropeptide Research. Insect Biochemistry and Molecular Biology, 86, pp. 9-19. (doi: 10.1016/j.ibmb.2017.05.001)

Cai, S., Papanatsiou, M., Blatt, M. R., Chen, Z.-H. (2017) Speedy grass stomata: emerging molecular and evolutionary features. Molecular Plant, 10, pp. 912-914. (doi: 10.1016/j.molp.2017.06.002)

Riedelsberger, J., Blatt, M. R. (2017) Editorial: Roots—the hidden provider. Frontiers in Plant Science, 8, (doi: 10.3389/fpls.2017.01021)

Cai, S., Chen, G., Wang, Y., Huang, Y., Marchant, B., Wang, Y., Yang, Q., Dai, F., Hills, A., Franks, P. J., Nevo, E., Soltis, D., Soltis, P., Sessa, E., Wolf, P. G., Xue, D., Zhang, G., Pogson, B. J., Blatt, M. R., Chen, Z.-H. (2017) Evolutionary conservation of ABA signaling for stomatal closure in ferns. Plant Physiology, 174, pp. 732-747. (doi: 10.1104/pp.16.01848)

Vialet-Chabrand, S., Hills, A., Wang, Y., Griffiths, H., Lew, V. L., Lawson, T., Blatt, M. R., Rogers, S. (2017) Global sensitivity analysis of OnGuard models identifies key hubs for transport interaction in stomatal dynamics. Plant Physiology, 174, pp. 680-688. (doi: 10.1104/pp.17.00170)

Vialet-Chabrand, S. R.M., Matthews, J. S.A., McAusland, L., Blatt, M. R., Griffiths, H., Lawson, T. (2017) Temporal dynamics of stomatal behavior: modeling and implications for photosynthesis and water use. Plant Physiology, 174, pp. 603-613. (doi: 10.1104/pp.17.00125)

Jezek, M., Blatt, M. R. (2017) The membrane transport system of the guard cell and its integration for stomatal dynamics. Plant Physiology, 174, pp. 487-519. (doi: 10.1104/pp.16.01949)

McVey, M., Finlay, C. (2017) Development of the Online Course for Campus Based Students: Current Directions in Life Sciences.

Griffiths, M., Finlay, C. (2017) Expanding Induction and Using the VLE to Enhance Induction to First-year Life Sciences.

Ballance, D., Browitt, A., Finlay, C., Griffiths, M., Rinaldi, C. (2017) What Works: Student Retention and Success Institutional Report.

Amtmann, A., Shahzad, Z. (2017) To respond or not to respond? Natural variation of root architectural responses to nutrient signals. Journal of Experimental Botany, 68, pp. 2636-2640. (doi: 10.1093/jxb/erx160)

Lumb, F. E., Doonan, J., Bell, K. S., Pineda, M. A., Corbet, M., Suckling, C. J., Harnett, M. M., Harnett, W. (2017) Dendritic cells provide a therapeutic target for synthetic small molecule analogues of the parasitic worm product, ES-62. Scientific Reports, 7, (doi: 10.1038/s41598-017-01651-1)

Papanatsiou, M., Amtmann, A., Blatt, M. R. (2017) Stomatal clustering in Begonia associates with the kinetics of leaf gaseous exchange and influences water use efficiency. Journal of Experimental Botany, 68, pp. 2309-2315. (doi: 10.1093/jxb/erx072)

Tanaka, M., Ishizuka, K., Nekooki-Machida, Y., Endo, R., Takashima, N., Sasaki, H., Komi, Y., Gathercole, A., Huston, E., Ishii, K., Hui, K. K.-W., Kurosawa, M., Kim, S.-H., Nukina, N., Takimoto, E., Houslay, M. D., Sawa, A. (2017) Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington’s disease. Journal of Clinical Investigation, 127, pp. 1438-1450. (doi: 10.1172/JCI85594)

Browitt, A., Ballance, D., Rinaldi, C., Finlay, C., Griffiths, M. (2017) Enhancing the Student Journey: Supporting Student Retention and Success.

Cannone, G., Visentin, S., Palud, A., Henneke, G., Spagnolo, L. (2017) Structure of an octameric form of the minichromosome maintenance protein from the archaeon Pyrococcus abyssi. Scientific Reports, 7, (doi: 10.1038/srep42019)

Dobson, A. J., Chaston, J. M., Douglas, A. E. (2017) Erratum to: The Drosophila transcriptional network is structured by microbiota. BMC Genomics, 18, (doi: 10.1186/s12864-017-3508-x)

Laté de Laté, P., Pineda, M., Harnett, M., Harnett, W., Besteiro, S., Langsley, G. (2017) Apicomplexan autophagy and modulation of autophagy in parasite-infected host cells. Biomedical Journal, 40, pp. 23-30. (doi: 10.1016/

Harnett, M. M., Pineda, M. A., Latré de Laté, P., Eason, R. J., Besteiro, S., Harnett, W., Langsley, G. (2017) From Christian de Duve to Yoshinori Ohsumi: more to autophagy than just dining at home. Biomedical Journal, 40, pp. 9-22. (doi: 10.1016/

Chen, Z.-H., Chen, G., Dai, F., Wang, Y., Hills, A., Ruan, Y.-L., Zhang, G., Franks, P. J., Nevo, E., Blatt, M. R. (2017) Molecular evolution of grass stomata. Trends in Plant Science, 22, pp. 124-139. (doi: 10.1016/j.tplants.2016.09.005)

Dobson, A. J., Ezcurra, M., Flanagan, C. E., Summerfield, A. C., Piper, M. D.W., Gems, D., Alic, N. (2017) Nutritional programming of lifespan by FOXO inhibition on sugar-rich diets. Cell Reports, 18, pp. 299-306. (doi: 10.1016/j.celrep.2016.12.029)

Karnik, R., Waghmare, S., Zhang, B., Larson, E., Lefoulon, C., Gonzalez, W., Blatt, M. R. (2017) Commandeering channel voltage sensors for secretion, cell turgor, and volume control. Trends in Plant Science, 22, pp. 81-95. (doi: 10.1016/j.tplants.2016.10.006)

Asensi-Fabado, M. A., Amtmann, A., Perrella, G. (2017) Plant responses to abiotic stress: the chromatin context of transcriptional regulation. Biochimica et Biophysica Acta: Gene Regulatory Mechanisms, 1860, pp. 106-122. (doi: 10.1016/j.bbagrm.2016.07.015)

Zhang, B., Karnik, R., Waghmare, S., Donald, N. A., Blatt, M. R. (2017) VAMP721 conformations unmask an extended motif for K+ channel binding and gating control. Plant Physiology, 173, pp. 536-551. (doi: 10.1104/pp.16.01549)

Antoniou-Kourounioti, R., Howard, M. (2017) Quantitative environmentally triggered switching between stable epigenetic states. Academic Press


Dobson, A. J., Chaston, J. M., Douglas, A. E. (2016) The Drosophila transcriptional network is structured by microbiota. BMC Genomics, 17, (doi: 10.1186/s12864-016-3307-9)

Eason, R. J., Bell, K. S., Marshall, F. A., Rodgers, D. T., Pineda, M., Steiger, C. N., Al-Riyami, L., Harnett, W., Harnett, M. M. (2016) The helminth product, ES-62 modulates dendritic cell responses by inducing the selective autophagolysosmal degradation of TLR-transducers, as exemplified by PKCδ. Scientific Reports, 6, (doi: 10.1038/srep37276)

Vialet-Chabrand, S., Matthews, J. S. A., Brendel, O., Blatt, M.R., Wang, Y., Hills, A., Griffiths, H., Rogers, S., Lawson, T. (2016) Modelling water use efficiency in a dynamic environment: an example using Arabidopsis thaliana. Plant Science, 251, pp. 65-74. (doi: 10.1016/j.plantsci.2016.06.016)

Papanatsiou, M., Amtmann, A., Blatt, M. R. (2016) Stomatal spacing safeguards stomatal dynamics by facilitating guard cell ion transport independent of the epidermal solute reservoir. Plant Physiology, 172, pp. 254-263. (doi: 10.1104/pp.16.00850)

Browitt, A., Finlay, C., Griffiths, M., Rinaldi, C., Ballance, D. (2016) Supporting Student Retention and Success at the University of Glasgow.

Overend, G., Luo, Y., Henderson, L., Douglas, A. E., Davies, S. A., Dow, J. A.T. (2016) Molecular mechanism and functional significance of acid generation in the Drosophila midgut. Scientific Reports, 6, (doi: 10.1038/srep27242)

Johnston, P. R., Dobson, A. J., Rolff, J. (2016) Genomic signatures of experimental adaptation to antimicrobial peptides in Staphylococcus aureus. G3: Genes, Genomes, Genetics, 6, pp. 1535-1539. (doi: 10.1534/g3.115.023622)

Makarova, O., Rodriguez-Rojas, A., Eravci, M., Weise, C., Dobson, A., Johnston, P., Rolff, J. (2016) Antimicrobial defence and persistent infection in insects revisited. Philosophical Transactions of the Royal Society B: Biological Sciences, 371, (doi: 10.1098/rstb.2015.0296)

Perrella, G., Carr, C., Asensi-Fabado, M. A., Donald, N. A., Páldi, K., Hannah, M. A., Amtmann, A. (2016) The Histone Deacetylase Complex (HDC) 1 protein of Arabidopsis thaliana has the capacity to interact with multiple proteins including histone 3-binding proteins and histone 1 variants. Plant Physiology, 171, pp. 62-70. (doi: 10.1104/pp.15.01760)

McVey, M., Finlay, C., Paschke, B., MacIntosh, G. (2016) Development and Student Evaluation of OPENSs – an Online Pre-Entry Nursing Summer School at the University of Glasgow.

Halberg, K. A., Rainey, S. M., Veland, I. R., Neuert, H., Dornan, A. J., Klämbt, C., Davies, S.-A., Dow, J. A.T. (2016) The cell adhesion molecule Fasciclin2 regulates brush border length and organization in Drosophila renal tubules. Nature Communications, 7, (doi: 10.1038/ncomms11266)

Chen, Z.-H., Wang, Y., Wang, J.-W., Babla, M., Zhao, C., Garcia-Mata, C., Sani, E., Differ, C., Mak, M., Hills, A., Amtmann, A., Blatt, M. R. (2016) Nitrate reductase mutation alters potassium nutrition as well as nitric oxide-mediated control of guard cell ion channels in Arabidopsis. New Phytologist, 209, pp. 1456-1469. (doi: 10.1111/nph.13714)

Regan, J. C., Khericha, M., Dobson, A. J., Bolukbasi, E., Rattanavirotkul, N., Partridge, L. (2016) Sex difference in pathology of the ageing gut mediates the greater response of female lifespan to dietary restriction. eLife, 5, (doi: 10.7554/eLife.10956)

Blatt, M. R. (2016) Plant physiology: redefining the enigma of metabolism in stomatal movement. Current Biology, 26, pp. R107-R109. (doi: 10.1016/j.cub.2015.12.025)

Chaston, J. M., Dobson, A. J., Newell, P. D., Douglas, A. E. (2016) Host genetic control of the microbiota mediates the Drosophila nutritional phenotype. Applied and Environmental Microbiology, 82, pp. 671-679. (doi: 10.1128/AEM.03301-15)

Minguet-Parramona, C., Wang, Y., Hills, A., Vialet-Chabrand, S., Griffiths, H., Rogers, S., Lawson, T., Lew, V. L., Blatt, M. R. (2016) An optimal frequency in Ca2+ oscillations for stomatal closure is an emergent property of ion transport in guard cells. Plant Physiology, 170, pp. 33-42. (doi: 10.1104/pp.15.01607)

Landry, G. M., Hirata, T., Anderson, J. B., Cabrero, P., Gallo, C. J.R., Dow, J. A.T., Romero, M. F. (2016) Sulfate and thiosulfate inhibit oxalate transport via a dPrestin(mSlc26a6)-dependent mechanism in an insect model of calcium oxalate nephrolithiasis. American Journal of Physiology: Renal Physiology, 310, pp. F152-F159. (doi: 10.1152/ajprenal.00406.2015)

Cannell, E., Dornan, A. J., Halberg, K. A., Terhzaza, S., Dow, J. A.T., Davies, S. A. (2016) The corticotropin-releasing factor-like diuretic hormone 44 (DH44) and kinin neuropeptides modulate desiccation and starvation tolerance in Drosophila melanogaster. Peptides, 80, (doi: 10.1016/j.peptides.2016.02.004)


Overend, G., Cabrero, P., Halberg, K. A.,, Ranford-Cartwright, L. C., Woods, D., Davies, S. A., Dow, J. A.T. (2015) A comprehensive transcriptomic view of renal function in the malaria vector, Anopheles gambiae. Insect Biochemistry and Molecular Biology, 67, pp. 47-58. (doi: 10.1016/j.ibmb.2015.05.007)

Terhzaz, S., Cabrero, P., Brinzer, R. A., Halberg, K. A., Dow, J. A.T., Davies, S.-A. (2015) A novel role of Drosophila cytochrome P450-4e3 in permethrin insecticide tolerance. Insect Biochemistry and Molecular Biology, 67, pp. 38-46. (doi: 10.1016/j.ibmb.2015.06.002)

Brinzer, R., Henderson, L., Marchiondo, A. A., Woods, D. J., Davies, S., Dow, J. A. T. (2015) Metabolomic profiling of permethrin-treated Drosophila melanogaster identifies a role for tryptophan catabolism in insecticide survival. Insect Biochemistry and Molecular Biology, 67, pp. 74-86. (doi: 10.1016/j.ibmb.2015.09.009)

Dow, J. A. T., Davies, S. A. (2015) What is an epitheliome, anyway? Insect Biochemistry and Molecular Biology, 67, pp. 1. (doi: 10.1016/j.ibmb.2015.10.013)

Rodgers, D. T., Pineda, M. A., Suckling, C. J., Harnett, W., Harnett, M. M. (2015) Drug-like analogues of the parasitic worm-derived immunomodulator ES-62 are therapeutic in the MRL/Lpr model of systemic lupus erythematosus. Lupus, 24, pp. 1437-1442. (doi: 10.1177/0961203315591031)

Al-Riyami, L., Rodgers, D. T., Rzepecka, J., Pineda, M. A., Suckling, C. J., Harnett, M. M., Harnett, W. (2015) Protective effect of small molecule analogues of the Acanthocheilonema viteae secreted product ES-62 on oxazolone-induced ear inflammation. Experimental Parasitology, 158, pp. 18-22. (doi: 10.1016/j.exppara.2015.03.025)

Pineda, M. A., Cuervo, H., Fresno, M., Soto, M., Bonay, P. (2015) Lack of galectin-3 prevents cardiac fibrosis and effective immune responses in a murine model of Trypanosoma cruzi infection. Journal of Infectious Diseases, 212, pp. 1160-1171. (doi: 10.1093/infdis/jiv185)

Chintapalli, V. R., Kato, A., Henderson, L., Hirata, T., Woods, D. J., Overend, G., Davies, S. A., Romero, M. F., Dow, J. A. T. (2015) Transport proteins NHA1 and NHA2 are essential for survival, but have distinct transport modalities. Proceedings of the National Academy of Sciences of the United States of America, 112, pp. 11720-11725. (doi: 10.1073/pnas.1508031112)

Grefen, C., Karnik, R., Larson, E., Lefoulon, C., Wang, Y., Waghmare, S., Zhang, B., Hills, A., Blatt, M. R. (2015) A vesicle-trafficking protein commandeers Kv channel voltage sensors for voltage-dependent secretion. Nature Plants, 1, (doi: 10.1038/nplants.2015.108)

Amtmann, A., Ma, H., Wagner, D. (2015) Chromatin and epigenetics. Plant Physiology, 168, pp. 1185-1188. (doi: 10.1104/pp.15.01023)

Dutta, D., Dobson, A. J., Houtz, P. L., Gläßer, C., Revah, J., Korzelius, J., Patel, P. H., Edgar, B. A., Buchon, N. (2015) Regional cell-specific transcriptome mapping reveals regulatory complexity in the adult Drosophila midgut. Cell Reports, 12, pp. 346-358. (doi: 10.1016/j.celrep.2015.06.009)

Rzepecka, J., Pineda, M. A., Al-Riyami, L., Rodgers, D. T., Huggan, J. K., Lumb, F. E., Khalaf, A. I., Meakin, P. J., Corbet, M., Ashford, M. L., Suckling, C. J., Harnett, M. M., Harnett, W. (2015) Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated counter-regulation of the inflammasome. Journal of Autoimmunity, 60, pp. 59-73. (doi: 10.1016/j.jaut.2015.04.005)

Zhang, B., Karnik, R., Wang, Y., Wallmeroth, N., Blatt, M. R., Grefen, C. (2015) The arabidopsis R-SNARE VAMP721 interacts with KAT1 and KC1 K+ channels to moderate K+ current at the plasma membrane. Plant Cell, 27, pp. 1697-1717. (doi: 10.1105/tpc.15.00305)

Dobson, A. J., Chaston, J. M., Newell, P. D., Donahue, L., Hermann, S. L., Sannino, D. R., Westmiller, S., Wong, A. C.-N., Clark, A. G., Lazzaro, B. P., Douglas, A. E. (2015) Corrigendum: Host genetic determinants of microbiota-dependent nutrition revealed by genome-wide analysis of Drosophila melanogaster. Nature Communications, 6, (doi: 10.1038/ncomms8296)

Papanatsiou, M., Scuffi, D., Blatt, M. R., Garia-Mata, C. (2015) Hydrogen sulphide regulates inward-rectifying K+ channels in conjunction with stomatal closure. Plant Physiology, 168, pp. 29-35. (doi: 10.1104/pp.114.256057)

Finlay, C., McVey, M., Paschke, B. (2015) A Pre-Entry Distance Course on Moodle: Articulating Course Expectations, Aiming to Impact on Access and Student Confidence.

DeLeeuw, J., Weir, J., Copsey, D., Roden, C., Deeley, S., Huston, E., McVey, M., Finlay, C. (2015) Developing Graduate Attributes and Improving Student Employability Through Work-based Learning: Opportunities, Successes and Challenges.

Pineda, M.A., Eason, R.J., Harnett, M.M., Harnett, W. (2015) From the worm to the pill, the parasitic worm product ES-62 raises new horizons in the treatment of rheumatoid arthritis. Lupus, 24, pp. 400-411. (doi: 10.1177/0961203314560004)

Rodgers, D. T., McGrath, M. A., Pineda, M. A., Al-Riyami, L., Rzepecka, J., Lumb, F., Harnett, W., Harnett, M. M. (2015) The parasitic worm product, ES-62 targets MyD88-dependent effector mechanisms to suppress ANA production and proteinuria in MRL/Lpr mice. Arthritis and Rheumatology, 67, pp. 1023-1035. (doi: 10.1002/art.39004)

Halberg, K., Terhzaz, S., Cabrero, P., Davies, S. A., Dow, J. A.T. (2015) Tracing the evolutionary origins of insect renal function. Nature Communications, 6, (doi: 10.1038/ncomms7800)

Terhzaz, S., Teets, N., Cabrero, P., Henderson, L., Richie, M. G., Nachman, R. J., Dow, J. A. T., Denlinger, D. L., Davies, S.-A. (2015) The insect capa neuropeptides impact desiccation and cold tolerance. Proceedings of the National Academy of Sciences of the United States of America, 112, pp. 2882-2887. (doi: 10.1073/pnas.1501518112)

Karnik, R., Zhang, B., Waghmare, S., Aderhold, C., Grefen, C., Blatt, M. R. (2015) Binding of SEC11 indicates its role in SNARE recycling after vesicle fusion and identifies two pathways for vesicular traffic to the plasma membrane. Plant Cell, 27, pp. 675-694. (doi: 10.1105/tpc.114.134429)

Dobson, A. J., Chaston, J. M., Newell, P. D., Donahue, L., Hermann, S. L., Sannino, D. R., Westmiller, S., Wong, A. C.-N., Clark, A. G., Lazzaro, B. P., Douglas, A. E. (2015) Host genetic determinants of microbiota-dependent nutrition revealed by genome-wide analysis of Drosophila melanogaster. Nature Communications, 6, (doi: 10.1038/ncomms7312)

Finlay, C. (2015) Does Size Matter? Biological Sciences Review, 27, pp. 2-6.

Pineda, M.A., Corvo, L., Soto, M., Fresno, M., Bonay, P. (2015) Interactions of human galectins with Trypanosoma cruzi: vinding profile correlate with genetic clustering of lineages. Glycobiology, 25, pp. 197-210. (doi: 10.1093/glycob/cwu103)

Cannone, G., Xu, Y., Beattie, T. R., Bell, S. D., Spagnolo, L. (2015) The architecture of an Okazaki fragment-processing holoenzyme from the archaeon Sulfolobus solfataricus. Biochemical Journal, 465, pp. 239-245. (doi: 10.1042/BJ20141120)

McVey, M., Finlay, C. (2015) Assessment Designed Around Graduate Attributes: Making Best Use of Available Technology to Foster Student Interaction and Support the Individual.

Minas, K., Karunakaran, E., Bond, T., Gandy, C., Honsbein, A., Madsen, M., Amezaga, J., Amtmann, A., Templeton, M.R., Biggs, C.A., Lawton, L. (2015) Biodesalination: an emerging technology for targeted removal of Na+and Cl−from seawater by cyanobacteria. Desalination and Water Treatment, 55, pp. 2647-2668. (doi: 10.1080/19443994.2014.940647)

Postgraduate research students

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Cellular and molecular biology techniques offer great power for understanding biological processes. However, in the Systems Biology theme, these techniques are used, as part of a varied experimental palette, to integrate a variety of different approaches to ultimately improve our knowledge of complex systems and organisms.

DNA spiral with computer code

This multi-facetted synthesis of information includes post-genomic molecular technologies; forward and reverse genetics of humans and model organisms; informatics, modelling, as well as imaging. Such a philosophy embraces core themes including:

  • Molecular Genetics, applying fundamental science to genetic variation and human disease, insect control for food security and the engineering of genetic circuits for Synthetic Biology.
  • Plant Science, understanding key mechanisms underlying plant-environment interactions and harnessing this information to increase plant productivity and sustainability.
  • Protein Structure and Regulation, examining the complexities associated with protein-protein interactions, protein trafficking and control networks that encompass key cellular processes.
  • Regenerative Medicine and Cellular Microenvironment, developing of engineering approaches to treat disease. 
  • Our core Glasgow Polyomics facility, with its associated specialist bioinformaticians, provide support in multi-omic systems approaches including next-generation sequencing, proteomics and metabolomics.