School of Molecular Biosciences

Zhang, X., Wang, Y., Supekar, S., Cao, X., Zhou, J., Dang, J., Chen, S., Jenkins, L., Marsango, S., Li, X., Liu, G., Milligan, G., Feng, M., Fan, H., Gong, W., Zhang, C. (2023) Pro-phagocytic function and structural basis of GPR84 signaling Nature Communications, 14, (doi: 10.1038/s41467-023-41201-0)

Irshad, Z., Lund, J., Sillars, A., Løvsletten, N. G., Gharanei, S., Salt, I. P., Freeman, D. J., Gill, J. M.R., Thoresen, G. H., Rustan, A. C., Zammit, V. A. (2023) The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background FASEB Journal,

Nguyen, T.-H., Silva-Alvim, F. A. L., Hills, A., Blatt, M. R. (2023) OnGuard3e: a predictive, ecophysiology‐ready tool for gas exchange and photosynthesis research Plant, Cell and Environment, (doi: 10.1111/pce.14674)

Ciba, M., Dibnah, B., Hudson, B. D., Ulven, E. R. (2023) Development and characterization of potent succinate receptor fluorescent tracers Journal of Medicinal Chemistry, 66, pp. 8951-8974. (doi: 10.1021/acs.jmedchem.3c00552)

Nguyen, T. B.-A., Lefoulon, C., Nguyen, T.-H., Blatt, M. R., Carroll, W. (2023) Engineering stomata for enhanced carbon capture and water-use efficiency Trends in Plant Science, (doi: 10.1016/j.tplants.2023.06.002)

Jaffery, H., Huesa, C., Cole, J., Doonan, J., Akbar, M., Dunning, L., Tanner, K. E., van 't Hof, R. J., McInnes, I. B., Carmody, R. J., Goodyear, C. S. (2023) The IĸB protein BCL3 controls osteogenesis and bone health Arthritis and Rheumatology, (doi: 10.1002/art.42639)

Karnik, R., Blatt, M. R. (2023) Analyzing protein–protein interactions using the split-ubiquitin system Humana Press

Dowsett, L., Duluc, L., Higgins, E., Alghamdi, F., Fast, W., Salt, I. P., Leiper, J. (2023) Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation Cellular Signalling, 107, (doi: 10.1016/j.cellsig.2023.110676)

Deni, I., Stokes, B. H., Ward, K. E., Fairhurst, K. J., Pasaje, C. F. A., Yeo, T., Akbar, S., Park, H., Muir, R., Bick, D. S., Zhan, W., Zhang, H., Liu, Y. J., Ng, C. L., Kirkman, L. A., Almaliti, J., Gould, A. E., Duffey, M., O'Donoghue, A. J., Uhlemann, A.-C., Niles, J. C., da Fonseca, P. C. A., Gerwick, W. H., Lin, G., Bogyo, M., Fidock, D. A. (2023) Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome Cell Chemical Biology, 30, pp. 470-485.e6. (doi: 10.1016/j.chembiol.2023.03.002)

Valentini, A., Schultz-Knudsen, K., Højgaard Hansen, A., Tsakoumagkou, A., Jenkins, L., Christensen, H. B., Manandhar, A., Milligan, G., Ulven, T., Rexen Ulven, E. (2023) Discovery of potent tetrazole free fatty acid receptor 2 antagonists Journal of Medicinal Chemistry, 66, pp. 6105-6121. (doi: 10.1021/acs.jmedchem.2c01935)

Milligan, G. (2023) GPR35: from enigma to therapeutic target Trends in Pharmacological Sciences, 44, pp. 263-273. (doi: 10.1016/j.tips.2023.03.001)

Javitt, A., Shmueli, M. D., Kramer, M. P., Kolodziejczyk, A. A., Cohen, I. J., Radomir, L., Sheban, D., Kamer, I., Litchfield, K., Bab-Dinitz, E., Zadok, O., Neiens, V., Ulman, A., Wolf-Levy, H., Eisenberg-Lerner, A., Kacen, A., Alon, M., Rêgo, A. T., Stacher-Priehse, E., Lindner, M., Koch, I., Bar, J., Swanton, C., Samuels, Y., Levin, Y., da Fonseca, P. C. A., Elinav, E., Friedman, N., Meiners, S., Merbl, Y. (2023) The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC Nature Cancer, 4, pp. 629-647. (doi: 10.1038/s43018-023-00557-4)

Marsango, S., Milligan, G. (2023) Regulation of the pro-inflammatory G protein-coupled receptor GPR84 British Journal of Pharmacology, (doi: 10.1111/bph.16098)

Adam, S., Zheng, D., Klein, A., Volz, C., Mullen, W., Shirran, S. L., Smith, B. O., Kalinina, O. V., Müller, R., Koehnke, J. (2023) Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis Nature Chemistry, 15, pp. 560-568. (doi: 10.1038/s41557-023-01153-w)

Meda Venkata, S. P., Li, H., Xu, L., Koh, J. Y., Nguyen, H., Minjares, M., Li, C., Kowluru, A., Milligan, G., Wang, J.-M. (2023) Inhibition of GPR39 restores defects in endothelial cell–mediated neovascularization under the duress of chronic hyperglycemia: evidence for regulatory roles of the sonic hedgehog signaling axis Proceedings of the National Academy of Sciences of the United States of America, 120, pp. e2208541120. (doi: 10.1073/pnas.2208541120)

Seale, M., Zhdanov, O., Soons, M. B., Cummins, C., Kroll, E., Blatt, M. R., Zare-Behtash, H., Busse, A., Mastropaolo, E., Bullock, J. M., Viola, I. M., Nakayama, N. (2022) Environmental morphing enables informed dispersal of the dandelion diaspore eLife, 11, (doi: 10.7554/eLife.81962)

Kowalczyk, D., Nakasone, M. A., Smith, B. O., Huang, D. T. (2022) Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function Life Science Alliance, 5, (doi: 10.26508/lsa.202201472)

Bremner, S., Al Shammari, W. O., Milligan, R. S., Hudson, B. D., Sutherland, C., Bryant, N. J., Gould, G. W. (2022) Pleiotropic effects of Syntaxin16 identified by gene editing in cultured adipocytes Frontiers in Cell and Developmental Biology, 10, (doi: 10.3389/fcell.2022.1033501)

Horaruang, W., Klejchová, M., Carroll, W., Silva-Alvim, F. A.L., Waghmare, S., Papanatsiou, M., Amtmann, A., Hills, A., Alvim, J. C., Blatt, M. R., Zhang, B. (2022) Engineering a K+ channel 'sensory antenna' enhances stomatal kinetics, water use efficiency and photosynthesis Nature Plants, 8, pp. 1262-1274. (doi: 10.1038/s41477-022-01255-2)

Gracie, J., Zamberlan, F., Andrews, I. B., Smith, B. O., Peveler, W. J. (2022) Growth of plasmonic nanoparticles for aging cask-matured whisky ACS Applied Nano Materials, 5, pp. 15362-15368. (doi: 10.1021/acsanm.2c03406)

Alharbi, A. G., Tobin, A. B., Milligan, G. (2022) How arrestins and GRKs regulate the function of long chain fatty acid receptors International Journal of Molecular Sciences, 23, (doi: 10.3390/ijms232012237)

Ryan, S. M., Ruscher, R., Johnston, W. A., Pickering, D. A., Kennedy, M. W., Smith, B. O., Jones, L., Buitrago, G., Field, M. A., Esterman, A. J., McHugh, C. P., Browne, D. J., Cooper, M. M., Ryan, R. Y. M., Doolan, D. L., Engwerda, C. R., Miles, K., Mitreva, M., Croese, J., Rahman, T., Alexandrov, K., Giacomin, P. R., Loukas, A. (2022) Novel antiinflammatory biologics shaped by parasite–host coevolution Proceedings of the National Academy of Sciences of the United States of America, 119, (doi: 10.1073/pnas.2202795119)

Mahindra, A., Jenkins, L., Marsango, S., Huggett, M., Huggett, M., Robinson, L., Gillespie, J., Rajamanickam, M., Morrison, A., McElroy, S., Tikhonova, I. G., Milligan, G., Jamieson, A. G. (2022) Investigating the structure–activity relationship of 1,2,4-triazine G-protein-coupled receptor 84 (GPR84) antagonists Journal of Medicinal Chemistry, 65, pp. 11270-11290. (doi: 10.1021/acs.jmedchem.2c00804)

Caspar, B., Cocchiara, P., Melet, A., Van Emelen, K., Van der Aa, A., Milligan, G., Herbeuval, J.-P. (2022) CXCR4 as a novel target in immunology: moving away from typical antagonists Future Drug Discovery, 4, (doi: 10.4155/fdd-2022-0007)

Kjeldsen, A., Kay, J. E., Baxter, S., McColm, S., Serrano-Amatriain, C., Parker, S., Robb, E., Arnold, S. A., Gilmour, C., Raper, A., Robertson, G., Fleming, R., Smith, B. O., Fotheringham, I. G., Christie, J. M., Magneschi, L. (2022) The fluorescent protein iLOV as a reporter for screening of high‐yield production of antimicrobial peptides in Pichia pastoris Microbial Biotechnology, 15, pp. 2126-2139. (doi: 10.1111/1751-7915.14034)

Marsango, S., Barki, N., Jenkins, L., Tobin, A. B., Milligan, G. (2022) Therapeutic validation of an orphan G protein-coupled receptor: the case of GPR84 British Journal of Pharmacology, 179, pp. 3529-3541. (doi: 10.1111/bph.15248)

Marsango, S., Jenkins, L., Pediani, J. D., Bradley, S. J., Ward, R. J., Hesse, S., Biener, G., Stoneman, M. R., Tobin, A. B., Raicu, V., Milligan, G. (2022) The M1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes Proceedings of the National Academy of Sciences of the United States of America, 119, (doi: 10.1073/pnas.2201103119)

Torres Cabán, C. C., Yang, M., Lai, C., Yang, L., Subach, F. V., Smith, B. O., Piatkevich, K. D., Boyden, E. S. (2022) Tuning the sensitivity of genetically encoded fluorescent potassium indicators through structure-guided and genome mining strategies ACS Sensors, 7, pp. 1336-1346. (doi: 10.1021/acssensors.1c02201)

Marsango, S., Ward, R. J., Jenkins, L., Butcher, A. J., Al Mahmud, Z., Dwomoh, L., Nagel, F., Schulz, S., Tikhonova, I. G., Tobin, A. B., Milligan, G. (2022) Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands Journal of Biological Chemistry, 298, (doi: 10.1016/j.jbc.2022.101932)

Thu, N. B.A., Amtmann, A., Blatt, M. R., Nguyen, T.-H. (2022) Stomata under salt stress—what can mechanistic modeling tell us? Academic Press

Živković, D., Sanchez Dafun, A., Menneteau, T., Schahl, A., Lise, S., Kervarrec, C., Toste Rêgo, A., da Fonseca, P. C. A., Chavent, M., Pineau, C., Burlet-Schiltz, O., Marcoux, J., Bousquet, M.-P. (2022) Proteasome complexes experience profound structural and functional rearrangements throughout mammalian spermatogenesis Proceedings of the National Academy of Sciences of the United States of America, 119, pp. e2116826119. (doi: 10.1073/pnas.2116826119)

Tibbo, A. J., Mika, D., Dobi, S., Ling, J., McFall, A., Tejeda, G. S., Blair, C., MacLeod, R., MacQuaide, N., Gök, C., Fuller, W., Smith, B. O., Smith, G. L., Vandecasteele, G., Brand, T., Baillie, G. S. (2022) Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins Journal of Molecular and Cellular Cardiology, 165, pp. 86-102. (doi: 10.1016/j.yjmcc.2022.01.001)

Barki, N., Bolognini, D., Börjesson, U., Jenkins, L., Riddell, J., Hughes, D. I., Ulven, T., Hudson, B. D., Rexen Ulven, E., Dekker, N., Tobin, A. B., Milligan, G. (2022) Chemogenetics defines the roles of short chain fatty acid receptors within the gut-brain axis eLife, 11, (doi: 10.7554/eLife.73777)

Divorty, N., Jenkins, L., Ganguly, A., Butcher, A. J., Hudson, B. D., Schulz, S., Tobin, A. B., Nicklin, S. A., Milligan, G. (2022) Agonist-induced phosphorylation of orthologues of the orphan receptor GPR35 functions as an activation sensor Journal of Biological Chemistry, 298, (doi: 10.1016/j.jbc.2022.101655)

Blatt, M. R., Jezek, M., Lew, V. L., Hills, A. (2022) What can mechanistic models tell us about guard cells, photosynthesis, and water use efficiency? Trends in Plant Science, 27, pp. 166-179. (doi: 10.1016/j.tplants.2021.08.010)

Nakasone, M. A., Majorek, K. A., Gabrielsen, M., Sibbet, G. J., Smith, B. O., Huang, D. T. (2022) Structure of UBE2K-Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension Nature Chemical Biology, 18, pp. 422-431. (doi: 10.1038/s41589-021-00952-x)

Neckebroeck, A., Kelly, S. M., Smith, B. O., Clark, J. S. (2022) Synthesis of the prototypical cyclopropyl dipeptide mimic and evaluation of its turn-inducing capability Journal of Organic Chemistry, 87, pp. 258-270. (doi: 10.1021/acs.joc.1c02344)

Zhdanov, O., Blatt, M. R., Zare-Behtash, H., Busse, A. (2022) Unidirectional versus bidirectional brushing: simulating wind influence on Arabidopsis thaliana Quantitative Plant Biology, 3, (doi: 10.1017/qpb.2021.14)

Scarpa, M., Molloy, C., Jenkins, L., Strellis, B., Budgett, R. F., Hesse, S., Dwomoh, L., Marsango, S., Tejeda, G. S., Rossi, M., Ahmed, Z., Milligan, G., Hudson, B. D., Tobin, A. B., Bradley, S. J. (2021) Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease Proceedings of the National Academy of Sciences of the United States of America, 118, pp. e2107389118. (doi: 10.1073/pnas.2107389118)

Lin, L.-C., Quon, T., Engberg, S., Mackenzie, A. E., Tobin, A. B., Milligan, G. (2021) G protein-coupled receptor GPR35 suppresses lipid accumulation in hepatocytes ACS Pharmacology and Translational Science, 4, pp. 1835-1848. (doi: 10.1021/acsptsci.1c00224)

Blatt, M. (2021) Ae fond fareweel Plant Physiology, 187, pp. 2341-2343. (doi: 10.1093/plphys/kiab467)

Kok, F. O., Wang, H., Riedlova, P., Goodyear, C. S., Carmody, R. J. (2021) Defining the structure of the NF-ĸB pathway in human immune cells using quantitative proteomic data Cellular Signalling, 88, (doi: 10.1016/j.cellsig.2021.110154)

Brown, A. J.H., Bradley, S. J., Marshall, F. H., Brown, G. A., Bennett, K. A., Brown, J., Cansfield, J. E., Cross, D. M., de Graaf, C., Hudson, B. D., Dwomoh, L., Dias, J. M., Errey, J. C., Hurrell, E., Liptrot, J., Mattedi, G., Molloy, C., Nathan, P. J., Okrasa, K., Osborne, G., Patel, J. C., Pickworth, M., Robertson, N., Shahabi, S., Bundgaard, C., Phillips, K., Broad, L. M., Goonawardena, A. V., Morairty, S. R., Browning, M., Perini, F., Dawson, G. R., Deakin, J. F.W., Smith, R. T., Sexton, P. M., Warneck, J., Vinson, M., Tasker, T., Tehan, B. G., Teobald, B., Christopoulos, A., Langmead, C. J., Jazayeri, A., Cooke, R. M., Rucktooa, P., Congreve, M. S., Weir, M., Tobin, A. B. (2021) From structure to clinic: design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer’s disease Cell, 184, pp. 5886-5901.e22. (doi: 10.1016/j.cell.2021.11.001)

Mahindra, A., Tejeda, G., Rossi, M., Janha, O., Herbert, I., Morris, C., Morgan, D. C., Beattie, W., Montezano, A. C., Hudson, B., Tobin, A. B., Bhella, D., Touyz, R. M., Jamieson, A. G., Baillie, G. S., Blair, C. M. (2021) Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction PLoS ONE, 16, (doi: 10.1371/journal.pone.0260283)

Somma, D., Kok, F. O., Kerrigan, D., Wells, C. A., Carmody, R. J. (2021) Defining the role of nuclear factor NF-κB p105 subunit in human macrophage by transcriptomic analysis of NFKB1 knockout THP-1 cells Frontiers in Immunology, 12, (doi: 10.3389/fimmu.2021.669906)

Milligan, G., Jenkins, L., Marsango, S., Mancini, S., Mahmud, Z. A., Morrison, A., McElroy, S., Bennett, K., Barnes, M., Tobin, A., Tikhonova, I. (2021) Discovery and characterization of novel antagonists of the proinflammatory orphan receptor GPR84 ACS Pharmacology and Translational Science, 4, pp. 1598-1613. (doi: 10.1021/acsptsci.1c00151)

Prabhakar, A. T., James, C. D., Das, D., Otoa, R., Day, M., Burgner, J., Fontan, C. T., Wang, X., Wieland, A., Donaldson, M. M., Bristol, M. L., Li, R., Oliver, A. W., Pearl, L. H., Smith, B. O., Glass, S., Morgan, I. M. (2021) CK2 phosphorylation of human papillomavirus 16 E2 on serine 23 promotes interaction with TopBP1 and is critical for E2 interaction with mitotic chromatin and the viral life cycle mBio, 12, (doi: 10.1128/mbio.01163-21)

Jezek, M., Silva-Alvim, F. A.L., Hills, A., Donald, N., Ishka, M. R., Shadbolt, J., He, B., Lawson, T., Harper, J. F., Wang, Y., Lew, V. L., Blatt, M. R. (2021) Guard cell endomembrane Ca2+-ATPases underpin a ‘carbon memory’ of photosynthetic assimilation that impacts on water-use efficiency Nature Plants, 7, pp. 1301-1313. (doi: 10.1038/s41477-021-00966-2)

Buist, H. K., Luchowska-Stańska, U., van Basten, B., Valli, J., Smith, B. O., Baillie, G. S., Rickman, C., Ricketts, B., Davidson, A., Hannam, R., Sunderland, J., Yarwood, S. J. (2021) Identification and characterization of an affimer affinity reagent for the detection of the cAMP sensor, EPAC1 Cells, 10, (doi: 10.3390/cells10092307)

Ahwazi, D., Neopane, K., Markby, G. R., Kopietz, F., Ovens, A. J., Dall, M., Hassing, A. S., Graesle, P., Alshuweishi, Y. A. I., Treebak, J. T., Salt, I., Göransson, O., Zeqiraj, E., Scott, J. W., Sakamoto, K. (2021) Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965 Biochemical Journal, 478, pp. 2977-2997. (doi: 10.1042/BCJ20210284)

Palmer, T. M., Salt, I. P. (2021) Nutrient regulation of inflammatory signalling in obesity and vascular disease Clinical Science, 135, pp. 1563-1590. (doi: 10.1042/CS20190768)

Morgan, D. C., Morris, C., Mahindra, A., Blair, C. M., Tejeda, G., Herbert, I., Turnbull, M. L., Lieber, G., Willett, B. J., Logan, N., Smith, B., Tobin, A. B., Bhella, D., Baillie, G. S., Jamieson, A. G. (2021) Stapled ACE2 peptidomimetics designed to target the SARS-CoV-2 spike protein do not prevent virus internalisation Peptide Science, 113, (doi: 10.1002/pep2.24217)

Boleij, A., Fathi, P., Dalton, W., Park, B., Wu, X., Huso, D., Allen, J., Besharati, S., Anders, R. A., Housseau, F., Mackenzie, A. E., Jenkins, L., Milligan, G., Wu, S., Sears, C. L. (2021) G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis Communications Biology, 4, (doi: 10.1038/s42003-021-02014-3)

Salt, I. P., Nunes, J. R.C., Fullerton, M. D. (2021) Metformin again? Atheroprotection mediated by macrophage AMPK and ATF1 Cardiovascular Research, 117, pp. 1233-1234. (doi: 10.1093/cvr/cvab065)

Morris, E. P., da Fonseca, P. C.A. (2021) How to build a proteasome Nature Structural and Molecular Biology, 28, pp. 409-410. (doi: 10.1038/s41594-021-00592-8)

Klejchova, M., Silva-Alvim, F. A.L., Blatt, M. R., Alvim, J. C. (2021) Membrane voltage as a dynamic platform for spatio-temporal signalling, physiological and developmental regulation Plant Physiology, 185, pp. 1523-1541. (doi: 10.1093/plphys/kiab032)

Milligan, G., Barki, N., Tobin, A. (2021) Chemogenetic approaches to explore the functions of Free Fatty Acid Receptor 2 Trends in Pharmacological Sciences, 42, pp. 191-202. (doi: 10.1016/j.tips.2020.12.003)

Zhdanov, O., Blatt, M. R., Zare-Behtash, H., Busse, A. (2021) Wind-evoked anemotropism affects the morphology and mechanical properties of Arabidopsis Journal of Experimental Botany, 72, pp. 1906-1918. (doi: 10.1093/jxb/eraa541)

Kopietz, F., Alshuweishi, Y., Bijland, S., Alghamdi, F., Degerman, E., Sakamoto, K., Salt, I. P., Göransson, O. (2021) A-769662 inhibits adipocyte glucose uptake in an AMPK-independent manner Biochemical Journal, 478, pp. 633-646. (doi: 10.1042/BCJ20200659)

Bolognini, D., Dedeo, D., Milligan, G. (2021) Metabolic and inflammatory functions of short-chain fatty acid receptors Current Opinion in Endocrine and Metabolic Research, 16, pp. 1-9. (doi: 10.1016/j.coemr.2020.06.005)

Knuhtsen, A., Whiting, R., McWhinnie, F. S., Whitmore, C., Smith, B. O., Green, A. C., Timperley, C. M., Kinnear, K. I., Jamieson, A. G. (2021) μ-conotoxin KIIIA peptidomimetics that block human voltage-gated sodium channels Peptide Science, 113, (doi: 10.1002/pep2.24203)

Ward, R. J., Pediani, J. D., Marsango, S., Jolly, R., Stoneman, M. R., Biener, G., Handel, T. M., Raicu, V., Milligan, G. (2021) Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t Journal of Biological Chemistry, 296, (doi: 10.1074/jbc.RA120.016612)

Zhdanov, O., Blatt, M. R., Cammarano, A., Zare-Behtash, H., Busse, A. (2020) A new perspective on mechanical characterisation of Arabidopsis stems through vibration tests Journal of the Mechanical Behavior of Biomedical Materials, 112, (doi: 10.1016/j.jmbbm.2020.104041)

Alghamdi, F., Alshuweishi, Y., Salt, I. P. (2020) Regulation of nutrient uptake by AMP-activated protein kinase Cellular Signalling, 76, (doi: 10.1016/j.cellsig.2020.109807)

Marti-Solano, M., Crilly, S. E., Malinverni, D., Munk, C., Harris, M., Pearce, A., Quon, T., Mackenzie, A. E., Wang, X., Peng, J., Tobin, A. B., Ladds, G., Milligan, G., Gloriam, D. E., Puthenveedu, M. A., Babu, M. M. (2020) Combinatorial expression of GPCR isoforms affects signalling and drug responses Nature, 587, pp. 650-656. (doi: 10.1038/s41586-020-2888-2)

Labéguère, F., Dupont, S., Alvey, L., Soulas, F., Newsome, G., Tirera, A., Quenehen, V., Mai, T. T. T., Deprez, P., Blanqué, R., Oste, L., Le Tallec, S., De Vos, S., Hagers, A., Vandevelde, A., Nelles, L., Vandervoort, N., Conrath, K., Christophe, T., van der Aar, E., Wakselman, E., Merciris, D., Cottereaux, C., da Costa, C., Saniere, L., Clement-Lacroix, P., Jenkins, L., Milligan, G., Fletcher, S., Brys, R., Gosmini, R. (2020) Discovery of 9-Cyclopropylethynyl-2-((S)-1-[1,4]dioxan-2-ylmethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one (GLPG1205), a unique GPR84 negative allosteric modulator undergoing evaluation in a phase II clinical trial Journal of Medicinal Chemistry, 63, pp. 13526-13545. (doi: 10.1021/acs.jmedchem.0c00272)

Chatrin, C., Gabrielsen, M., Buetow, L., Nakasone, M. A., Ahmed, S. F., Sumpton, D., Sibbet, G. J., Smith, B. O., Huang, D. T. (2020) Structural insights into ADP-ribosylation of ubiquitin by Deltex family E3 ubiquitin ligases Science Advances, 6, (doi: 10.1126/sciadv.abc0418)

Lefoulon, C., Boxall, S. F., Hartwell, J., Blatt, M. R. (2020) Crassulacean acid metabolism guard cell anion channel activity follows transcript abundance and is suppressed by apoplastic malate New Phytologist, 227, pp. 1847-1857. (doi: 10.1111/nph.16640)

Larson, E. R., Ortmannová, J., Donald, N. A., Alvim, J., Blatt, M. R., Žárský, V. (2020) Synergy among exocyst and SNARE interactions identifies a functional hierarchy in secretion during vegetative growth Plant Cell, 32, pp. 2951-2963. (doi: 10.1105/tpc.20.00280)

Prihandoko, R., Kaur, D., Wiegman, C. H., Alvarez-Curto, E., Donovan, C., Chachi, L., Ulven, T., Tyas, M. R., Euston, E., Dong, Z., Alharbi, A. G. M., Kim, R. Y., Lowe, J. G., Hansbro, P. M., Chung, K. F., Brightling, C. E., Milligan, G., Tobin, A. B. (2020) Pathophysiological regulation of lung function by the free fatty acid receptor FFA4 Science Translational Medicine, 12, (doi: 10.1126/scitranslmed.aaw9009)

Mitxitorena, I., Somma, D., Mitchell, J. P., Lepistö, M., Tyrchan, C., Smith, E. L., Kiely, P. A., Walden, H., Keeshan, K., Carmody, R. J. (2020) The deubiquitinase USP7 uses a distinct ubiquitin-like domain to deubiquitinate NF-ĸB subunits Journal of Biological Chemistry, 295, pp. 11754-11763. (doi: 10.1074/jbc.RA120.014113)

Jezek, M., Hills, A., Blatt, M. R., Lew, V. L. (2020) A constraint-relaxation-recovery mechanism for stomatal dynamics Plant, Cell and Environment, 42, pp. 2399-2410. (doi: 10.1111/pce.13568)

Quon, T., Lin, L.-C., Ganguly, A., Tobin, A. B., Milligan, G. (2020) Therapeutic opportunities and challenges in targeting the orphan G protein-coupled receptor GPR35 ACS Pharmacology and Translational Science, 3, pp. 801-812. (doi: 10.1021/acsptsci.0c00079)

Flütsch, S., Wang, Y., Takemiya, A., Vialet-Chabrand, S. R., Klejchova, M., Nigro, A., Hills, A., Lawson, T., Blatt, M. R., Santelia, D. (2020) Guard cell starch degradation yields glucose for rapid stomatal opening in Arabidopsis Plant Cell, 32, pp. 2325-2344. (doi: 10.1105/tpc.18.00802)

Sarrou, E., Richmond, L., Carmody, R. J., Gibson, B., Keeshan, K. (2020) CRISPR gene editing of murine blood stem and progenitor cells induces MLL-AF9 chromosomal translocation and MLL-AF9 leukaemogenesis International Journal of Molecular Sciences, 21, (doi: 10.3390/ijms21124266)

Klejchová, M., Hills, A., Blatt, M. R. (2020) Predicting the unexpected in stomatal gas exchange: not just an open-and-shut case Biochemical Society Transactions, 48, pp. 881-889. (doi: 10.1042/BST20190632)

Crecente Garcia, S., Neckebroeck, A., Clark, J. S., Smith, B. O., Thomson, A. R. (2020) β-turn mimics by chemical ligation Organic Letters, 22, pp. 4424-4428. (doi: 10.1021/acs.orglett.0c01427)

Rexen Ulven, E., Quon, T., Sergeev, E., Barki, N., Brvar, M., Hudson, B. D., Dutta, P., Højgaard Hansen, A., Bielefeldt, L. Ø., Tobin, A. B., McKenzie, C. J., Milligan, G., Ulven, T. (2020) Structure-activity relationship studies of tetrahydroquinolone free fatty acid receptor 3 modulators Journal of Medicinal Chemistry, 63, pp. 3577-3595. (doi: 10.1021/acs.jmedchem.9b02036)

Horaruang, W., Hills, A., Blatt, M. R. (2020) Communication between the plasma membrane and tonoplast is an emergent property of ion transport Plant Physiology, 182, pp. 1833-1835. (doi: 10.1104/pp.19.01485)

Sencio, V., Barthelemy, A., Tavares, L. P., Machado, M. G., Soulard, D., Cuinat, C., Queiroz-Junior, C. M., Noordine, M. L., Salomé-Desnoulez, S., Deryuter, L., Foligné, B., Wahl, C., Frisch, B., Vieira, A. T., Paget, C., Milligan, G., Ulven, T., Wolowczuk, I., Faveeuw, C., Le Goffic, R., Thomas, M., Ferreira, S., Teixeira, M. M., Trottein, F. (2020) Gut dysbiosis during influenza contributes to pulmonary pneumococcal superinfection through altered short-chain fatty acid production Cell Reports, 30, pp. 2934-2947.e6. (doi: 10.1016/j.celrep.2020.02.013)

Collins, P. E., Somma, D., Kerrigan, D., Herrington, F., Keeshan, K. R., Nibbs, R. J.B., Carmody, R. J. (2019) The IκB-protein BCL-3 controls toll-like receptor-induced MAPK activity by promoting TPL-2 degradation in the nucleus Proceedings of the National Academy of Sciences of the United States of America, 116, pp. 25828-25838. (doi: 10.1073/pnas.1900408116)

Heuninck, J., Perpina Viciano, C., Işbilir, A., Caspar, B., Capoferri, D., Briddon, S. J., Durroux, T., Hill, S. J., Lohse, M. J., Milligan, G., Pin, J.-P., Hoffmann, C. (2019) Context-dependent signaling of CXC chemokine receptor 4 and atypical chemokine receptor 3 Molecular Pharmacology, 96, pp. 778-793. (doi: 10.1124/mol.118.115477)

Smith, E. L., Somma, D., Kerrigan, D., McIntyre, Z., Cole, J. J., Liang, K. L., Kiely, P. A., Keeshan, K., Carmody, R. J. (2019) The regulation of sequence specific NF-ĸB DNA binding and transcription by IKKβ Phosphorylation of NF-ĸB p50 at Serine 80 Nucleic Acids Research, 47, pp. 11151-11161. (doi: 10.1093/nar/gkz873)

Waghmare, S., Lefoulon, C., Zhang, B., Lileikyte, E., Donald, N., Blatt, M. (2019) K+ channel and SEC11 binding exchange regulates SNARE assembly for secretory traffic Plant Physiology, 181, pp. 1096-1113. (doi: 10.1104/pp.19.00919)

Zhdanov, O., Busse, A., Cammarano, A., Zare-Behtash, H., Blatt, M. (2019) Effect of Wind on Morphology and Mechanical Properties of Arabidopsis Thaliana

Toste Rêgo, A., da Fonseca, P. C.A. (2019) Characterization of fully recombinant human 20S and 20S-PA200 proteasome complexes Molecular Cell, 76, pp. 138-147.e5. (doi: 10.1016/j.molcel.2019.07.014)

Jurić, I., Hibberd, J. M., Blatt, M., Burroughs, N. J. (2019) Computational modelling predicts substantial carbon assimilation gains for C3 plants with a single-celled C4 biochemical pump PLoS Computational Biology, 15, (doi: 10.1371/journal.pcbi.1007373)

Ibáñez-Shimabukuro, M., Rey-Burusco, M. F., Gabrielsen, M., Franchini, G. R., Riboldi-Tunnicliffe, A., Roe, A. J., Griffiths, K., Cooper, A., Córsico, B., Kennedy, M. W., Smith, B. O. (2019) Structure and ligand binding of As-p18, an extracellular fatty acid binding protein from the eggs of a parasitic nematode Bioscience Reports, 39, (doi: 10.1042/BSR20191292)

Katwan, O. J., Alghamdi, F., Almabrouk, T. A., Mancini, S. J., Kennedy, S., Oakhill, J. S., Scott, J. W., Salt, I. P. (2019) AMP-activated protein kinase complexes containing the β2 regulatory subunit are upregulated during and contribute to adipogenesis Biochemical Journal, 476, pp. 1725-1740. (doi: 10.1042/BCJ20180714)

Blackman, M. J., Stokes, B. H., Yoo, E., Murithi, J. M., Luth, M. R., Afanasyev, P., da Fonseca, P. C.A., Winzeler, E. A., Ng, C. L., Bogyo, M., Fidock, D. A. (2019) Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents PLoS Pathogens, 15, (doi: 10.1371/journal.ppat.1007722)

Stoneman, M. R., Biener, G., Ward, R. J., Pediani, J. D., Badu, D., Eis, A., Popa, I., Milligan, G., Raicu, V. (2019) A general method to quantify ligand-driven oligomerization from fluorescence-based images Nature Methods, 16, pp. 493-496. (doi: 10.1038/s41592-019-0408-9)

Bolognini, D., Barki, N., Butcher, A. J., Hudson, B. D., Sergeev, E., Molloy, C., Moss, C. E., Bradley, S. J., Le Gouill, C., Bouvier, M., Tobin, A. B., Milligan, G. (2019) Chemogenetics defines receptor-mediated functions of short chain free fatty acids Nature Chemical Biology, 15, pp. 489-498. (doi: 10.1038/s41589-019-0270-1)

Zhang, B., Karnik, R., Alvim, J., Donald, N., Blatt, M. R. (2019) Dual sites for SEC11 on the SNARE SYP121 implicate a binding exchange during secretory traffic Plant Physiology, 180, pp. 228-239. (doi: 10.1104/pp.18.01315)

Milligan, G., Ward, R. J., Marsango, S. (2019) GPCR homo-oligomerization Current Opinion in Cell Biology, 57, pp. 40-47. (doi: 10.1016/j.ceb.2018.10.007)

Mackenzie, A. E., Quon, T., Lin, L.-C., Hauser, A. S., Jenkins, L., Inoue, A., Tobin, A. B., Gloriam, D. E., Hudson, B. D., Milligan, G. (2019) Receptor selectivity between the G proteins Gα12 and Gα13 is defined by a single leucine-to-isoleucine variation FASEB Journal, 33, pp. 5005-5017. (doi: 10.1096/fj.201801956R)

Papanatsiou, M., Petersen, J., Henderson, L., Wang, Y., Christie, J.M., Blatt, M.R. (2019) Optogenetic manipulation of stomatal kinetics improves carbon assimilation, water use, and growth Science, 363, pp. 1456-1459. (doi: 10.1126/science.aaw0046)

Zhao, C., Wang, Y., Chan, K. X., Marchant, D. B., Franks, P. J., Randall, D., Tee, E. E., Chen, G., Ramesh, S., Phua, S. Y., Zhang, B., Hills, A., Dai, F., Xue, D., Gilliham, M., Tyerman, S., Nevo, E., Wu, F., Zhang, G., Wong, G. K.-S., Leebens-Mack, J. H., Melkonian, M., Blatt, M. R., Soltis, P. S., Soltis, D. E., Pogson, B. J., Chen, Z.-H. (2019) Evolution of chloroplast retrograde signaling facilitates green plant adaptation to land Proceedings of the National Academy of Sciences of the United States of America, 116, pp. 5015-5020. (doi: 10.1073/pnas.1812092116)

Knuhtsen, A., Whitmore, C., McWhinnie, F. S., McDougall, L., Whiting, R., Smith, B. O., Timperley, C. M., Green, A. C., Kinnear, K. I., Jamieson, A. G. (2019) α-conotoxin GI triazole-peptidomimetics: potent and stable blockers of a human acetylcholine receptor Chemical Science, 10, pp. 1671-1676. (doi: 10.1039/C8SC04198A)

Mancini, S., Mahmud, Z. A., Jenkins, L., Bolognini, D., Newman, R., Barnes, M., Edye, M. E., McMahon, S. B., Tobin, A. B., Milligan, G. (2019) On-target and off-target effects of novel orthosteric and allosteric activators of GPR84 Scientific Reports, 9, (doi: 10.1038/s41598-019-38539-1)

Liao, X., Zhang, B., Blatt, M. R., Jenkins, G. I. (2019) A FRET method for investigating dimer/monomer status and conformation of the UVR8 photoreceptor Photochemical and Photobiological Sciences, 18, pp. 367-374. (doi: 10.1039/C8PP00489G)

Müskens, F. M., Ward, R. J., Herkt, D., van de Langemheen, H., Tobin, A. B., Liskamp, R. M.J., Milligan, G. (2019) Design, synthesis and evaluation of a diazirine photoaffinity probe for ligand-based receptor capture targeting G protein-coupled receptors Molecular Pharmacology, 95, pp. 196-209. (doi: 10.1124/mol.118.114249)

Petrie, J. R., Salt, I. P. (2019) Diabetes and vascular disease Springer

Rezig, I. M., Bremner, S. K., Bhutta, M. S., Salt, I. P., Gould, G. W., McInerny, C. J. (2019) Genetic and cytological methods to study ESCRT cell cycle function in fission yeast Humana Press

Strembitska, A., Mancini, S. J., Gamwell, J. M., Palmer, T. M., Baillie, G. S., Salt, I. P. (2018) A769662 inhibits insulin-stimulated Akt activation in human macrovascular endothelial cells independent of AMP-activated protein kinase International Journal of Molecular Sciences, 19, (doi: 10.3390/ijms19123886)

Waghmare, S., Lileikyte, E., Karnik, R., Goodman, J. K., Blatt, M. R., Jones, A. M.E. (2018) SNAREs SYP121 and SYP122 mediate the secretion of distinct cargo subsets Plant Physiology, 178, pp. 1679-1688. (doi: 10.1104/pp.18.00832)

Kennedy, A. J., Ballante, F., Johansson, J. R., Milligan, G., Sunström, L., Nordqvist, A., Carlsson, J. (2018) Structural characterization of agonist binding to protease-activated receptor 2 through mutagenesis and computational modeling ACS Pharmacology and Translational Science, 1, pp. 119-133. (doi: 10.1021/acsptsci.8b00019)

Hansen, A. H., Sergeev, E., Bolognini, D., Sprenger, R. R., Ekberg, J. H., Ejsing, C. S., McKenzie, C. J., Rexen Ulven, E., Milligan, G., Ulven, T. (2018) Discovery of a potent thiazolidine free fatty acid receptor 2 agonist with favorable pharmacokinetic properties Journal of Medicinal Chemistry, 61, pp. 9534-9550. (doi: 10.1021/acs.jmedchem.8b00855)

Lefoulon, C., Waghmare, S., Karnik, R., Blatt, M. R. (2018) Gating control and K+ uptake by the KAT1 K+ channel leaveraged through membrane anchoring of the trafficking protein SYP121 Plant, Cell and Environment, 41, pp. 2668-2677. (doi: 10.1111/pce.13392)

Drew, J. E., Reichardt, N., Williams, L. M., Mayer, C.-D., Walker, A. W., Farquharson, A. J., Kastora, S., Farquharson, F., Milligan, G., Morrison, D. J., Preston, T., Flint, H. J., Louis, P. (2018) Dietary fibers inhibit obesity in mice, but host responses in the cecum and liver appear unrelated to fiber-specific changes in cecal taxonomic composition Scientific Reports, 8, (doi: 10.1038/s41598-018-34081-8)

Zhang, B., Karnik, R., Donald, N., Blatt, M. R. (2018) A GPI signal peptide-anchored split-ubiquitin (GPS) system for detecting soluble bait protein interactions at the membrane Plant Physiology, 178, pp. 13-17. (doi: 10.1104/pp.18.00577)

Divorty, N., Milligan, G., Graham, D., Nicklin, S. A. (2018) The orphan receptor GPR35 contributes to angiotensin II–induced hypertension and cardiac dysfunction in mice American Journal of Hypertension, 31, pp. 1049-1058. (doi: 10.1093/ajh/hpy073)

Feroz, H., Ferlez, B., Lefoulon, C., Ren, T., Baker, C. S., Gajewski, J. P., Lugar, D. J., Gaudana, S. B., Butler, P. J., Hühn, J., Lamping, M., Parak, W. J., Hibberd, J. M., Kerfeld, C. A., Smirnoff, N., Blatt, M. R., Golbeck, J. H., Kumar, M. (2018) Light-driven chloride transport kinetics of halorhodopsin Biophysical Journal, 115, pp. 353-360. (doi: 10.1016/j.bpj.2018.06.009)

Marsango, S., Ward, R. J., Alvarez-Curto, E., Milligan, G. (2018) Muscarinic receptor oligomerization Neuropharmacology, 136, pp. 401-410. (doi: 10.1016/j.neuropharm.2017.11.023)

Binti Mohd Amir, N. A.S., Mackenzie, A. E., Jenkins, L., Boustani, K., Hillier, M. C., Tsuchiya, T., Milligan, G., Pease, J. E. (2018) Evidence for the existence of a CXCL17 receptor distinct from GPR35 Journal of Immunology, 201, pp. 714-724. (doi: 10.4049/jimmunol.1700884)

Milligan, G. (2018) G protein-coupled receptors not currently in the spotlight: free fatty acid receptor 2 and GPR35 British Journal of Pharmacology, 175, pp. 2543-2553. (doi: 10.1111/bph.14042)

Zhdanov, O., Busse, A., Blatt, M., Zare-Behtash, H. (2018) A specialised wind tunnel for investigation of ecophysiological response of plants to wind

Butcher, S. K., O'Carroll, C. E., Wells, C. A., Carmody, R. J. (2018) Toll-like receptors drive specific patterns of tolerance and training on restimulation of macrophages Frontiers in Immunology, 9, (doi: 10.3389/fimmu.2018.00933)

Salomé, M., Magee, A., Yalla, K., Chaudhury, S., Sarrou, E., Carmody, R. J., Keeshan, K. (2018) A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling Cell Death and Disease, 9, (doi: 10.1038/s41419-018-0467-3)

Milligan, G., Inoue, A. (2018) Genome editing provides new insights into receptor-controlled signalling pathways Trends in Pharmacological Sciences, 39, pp. 481-493. (doi: 10.1016/j.tips.2018.02.005)

Blatt, M. R. (2018) Concepts and techniques in plant membrane physiology John Wiley & Sons, Ltd

Blatt, M.R., Thiel, G. (2018) SNARE components and mechanisms of exocytosis in plants John Wiley & Sons, Ltd

Mancini, S. J., Boyd, D., Katwan, O. J., Strembitska, A., Almabrouk, T. A., Kennedy, S., Palmer, T. M., Salt, I. P. (2018) Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms Scientific Reports, 8, (doi: 10.1038/s41598-018-23420-4)

Almabrouk, T. A.M., White, A. D., Ugusman, A. B., Skiba, D. S., Katwan, O. J., Alganga, H., Guzik, T. J., Touyz, R. M., Salt, I. P., Kennedy, S. (2018) High fat diet attenuates the anticontractile activity of aortic PVAT via a mechanism involving AMPK and reduced adiponectin secretion Frontiers in Physiology, 9, (doi: 10.3389/fphys.2018.00051)

Speirs, C., Williams, J. J.L., Riches, K., Salt, I. P., Palmer, T. M. (2018) Linking energy sensing to suppression of JAK-STAT signalling: a potential route for repurposing AMPK activators? Pharmacological Research, 128, pp. 88-100. (doi: 10.1016/j.phrs.2017.10.001)

Pediani, J. D., Ward, R. J., Marsango, S., Milligan, G. (2018) Spatial intensity distribution analysis: studies of G Protein-coupled receptor oligomerization Trends in Pharmacological Sciences, 39, pp. 175-186. (doi: 10.1016/j.tips.2017.09.001)

Pantin, F., Blatt, M. R. (2018) Stomatal response to humidity: blurring the boundary between active and passive movement Plant Physiology, 176, pp. 485-488. (doi: 10.1104/pp.17.01699)

Mancini, S. J., Salt, I. P. (2018) Investigating the role of AMPK in inflammation Humana Press

Mitchell, J. P., Carmody, R. J. (2018) NF-κB and the Transcriptional Control of Inflammation Elsevier

Reichardt, N., Vollmer, M., Holtrop, G., Farquharson, F. M., Wefers, D., Bunzel, M., Duncan, S. H., Drew, J. E., Williams, L. M., Milligan, G., Preston, T., Morrison, D., Flint, H. J., Louis, P. (2018) Specific substrate-driven changes in human faecal microbiota composition contrast with functional redundancy in short-chain fatty acid production ISME Journal, 12, pp. 610-622. (doi: 10.1038/ismej.2017.196)

Mahmud, Z. A., Jenkins, L., Ulven, T., Labéguère, F., Gosmini, R., De Vos, S., Hudson, B. D., Tikhonova, I. G., Milligan, G. (2017) Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84 Scientific Reports, 7, (doi: 10.1038/s41598-017-18159-3)

Viskaitis, P., Irvine, E. E., Smith, M. A., Choudhury, A. I., Alvarez-Curto, E., Glegola, J. A., Hardy, D. G., Pedroni, S. M.A., Paiva Pessoa, M. R., Fernando, A. B.P., Katsouri, L., Sardini, A., Ungless, M. A., Milligan, G., Withters, D. J. (2017) Modulation of SF1 neuron activity coordinately regulates both feeding behaviour and associated emotional states Cell Reports, 21, pp. 3559-3572. (doi: 10.1016/j.celrep.2017.11.089)

Cooper, A., Vance, S. J., Smith, B. O., Kennedy, M. W. (2017) Frog foams and natural protein surfactants Colloids and Surfaces A: Physicochemical and Engineering Aspects, 534, pp. 120-129. (doi: 10.1016/j.colsurfa.2017.01.049)

Wang, Y., Hills, A., Vialet-Chabrand, S., Papanatsiou, M., Griffiths, H., Rogers, S., Lawson, T., Lew, V. L., Blatt, M. R. (2017) Unexpected connections between humidity and ion transport discovered using a model to bridge guard cell-to-leaf scales Plant Cell, 29, pp. 2921-2939. (doi: 10.1105/tpc.17.00694)

Sergeev, E., Hansen, A. H., Bolognini, D., Kawakami, K., Kishi, T., Aoki, J., Ulven, T., Inoue, A., Hudson, B. D., Milligan, G. (2017) A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias Scientific Reports, 7, (doi: 10.1038/s41598-017-14096-3)

Gabrielsen, M., Buetow, L., Nakasone, M. A., Ahmed, S. F., Sibbet, G. J., Smith, B. O., Zhang, W., Sidhu, S. S., Huang, D. T. (2017) A general strategy for discovery of inhibitors and activators of RING and U-box E3 ligases with ubiquitin variants Molecular Cell, 68, pp. 456-470.e10. (doi: 10.1016/j.molcel.2017.09.027)

Larson, E. R., Van Zelm, E., Roux, C., Marion-Poll, A., Blatt, M. R. (2017) Clathrin Heavy Chain subunits coordinate endo- and exocytic traffic and affect stomatal movement Plant Physiology, 175, pp. 708-720. (doi: 10.1104/pp.17.00970)

Almabrouk, T. A. M., Ugusman, A. B., Katwan, O. J., Salt, I. P., Kennedy, S. (2017) Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adiponectin release British Journal of Pharmacology, 174, pp. 3398-3410. (doi: 10.1111/bph.13633)

Kennedy, S., Salt, I. P. (2017) Molecular mechanisms regulating perivascular adipose tissue - potential pharmacological targets? British Journal of Pharmacology, 174, pp. 3385-3387. (doi: 10.1111/bph.13969)

Magennis, S., Toulmin, A., Baltierra-Jasso, L. E., Morten, M. J., Sabir, T., McGlynn, P., Schröder, G. F., Smith, B. O., Magennis, S. W. (2017) Conformational heterogeneity in a fully-complementary DNA three-way junction with a GC-rich branchpoint Biochemistry, 56, pp. 4985-4991. (doi: 10.1021/acs.biochem.7b00677)

Milligan, G., Alvarez-Curto, E., Hudson, B. D., Prihandoko, R., Tobin, A. B. (2017) FFA4/GPR120: pharmacology and therapeutic opportunities Trends in Pharmacological Sciences, 38, pp. 809-821. (doi: 10.1016/j.tips.2017.06.006)

(2017) G-Protein-Coupled Receptor Dimers (doi: 10.1007/978-3-319-60174-8)

Ward, R. J., Marsango, S., Pediani, J. D., Milligan, G. (2017) The use of spatial intensity distribution analysis to examine G protein-coupled receptor oligomerization Humana Press

Prokop, S., Perry, N. A., Vishnivetskiy, S. A., Toth, A. D., Inoue, A., Milligan, G., Iverson, T. M., Hunyady, L., Gurevich, V. V. (2017) Differential manipulation of arrestin-3 binding to basal and agonist-activated G protein-coupled receptors Cellular Signalling, 36, pp. 98-107. (doi: 10.1016/j.cellsig.2017.04.021)

Spies, M., Smith, B. O. (2017) Protein-nucleic acids interactions: new ways of connecting structure, dynamics and function Biophysical Reviews, 9, pp. 289-291. (doi: 10.1007/s12551-017-0284-4)

Lopez-Gimenez, J., Alvarez-Curto, E., Milligan, G. (2017) M3 muscarinic acetylcholine receptor facilitates the endocytosis of mu opioid receptor mediated by morphine independently of the formation of heteromeric complexes Cellular Signalling, 35, pp. 208-222. (doi: 10.1016/j.cellsig.2017.04.006)

Cai, S., Papanatsiou, M., Blatt, M. R., Chen, Z.-H. (2017) Speedy grass stomata: emerging molecular and evolutionary features Molecular Plant, 10, pp. 912-914. (doi: 10.1016/j.molp.2017.06.002)

Riedelsberger, J., Blatt, M. R. (2017) Editorial: Roots—the hidden provider Frontiers in Plant Science, 8, (doi: 10.3389/fpls.2017.01021)

Shaw, A., Jeromson, S., Watterson, K. R., Pediani, J. D., Gallagher, I., Whalley, T., Dreczkowski, G., Brooks, N., Galloway, S., Hamilton, D. L. (2017) Multiple AMPK activators inhibit L-Carnitine uptake in C2C12 skeletal muscle myotubes American Journal of Physiology: Cell Physiology, 312, pp. C689-C696. (doi: 10.1152/ajpcell.00026.2016)

Cai, S., Chen, G., Wang, Y., Huang, Y., Marchant, B., Wang, Y., Yang, Q., Dai, F., Hills, A., Franks, P. J., Nevo, E., Soltis, D., Soltis, P., Sessa, E., Wolf, P. G., Xue, D., Zhang, G., Pogson, B. J., Blatt, M. R., Chen, Z.-H. (2017) Evolutionary conservation of ABA signaling for stomatal closure in ferns Plant Physiology, 174, pp. 732-747. (doi: 10.1104/pp.16.01848)

Vialet-Chabrand, S., Hills, A., Wang, Y., Griffiths, H., Lew, V. L., Lawson, T., Blatt, M. R., Rogers, S. (2017) Global sensitivity analysis of OnGuard models identifies key hubs for transport interaction in stomatal dynamics Plant Physiology, 174, pp. 680-688. (doi: 10.1104/pp.17.00170)

Morris, E. P., da Fonseca, P. C.A. (2017) High-resolution cryo-EM proteasome structures in drug development Acta Crystallographica. Section D: Structural Biology, 73, pp. 522-533. (doi: 10.1107/S2059798317007021)

Watterson, K. R., Hansen, S. V.F., Hudson, B., Alvarez-Curto, E., Raihan, S. Z., Azevedo, C. M.G., Martin, G., Dunlop, J., Yarwood, S. J., Ulven, T., Milligan, G. (2017) Probe-dependent negative allosteric modulators of the long-chain free fatty acid receptor FFA4 Molecular Pharmacology, 91, pp. 630-641. (doi: 10.1124/mol.116.107821)

Ward, R. J., Pediani, J. D., Harikumar, K. G., Miller, L. J., Milligan, G. (2017) Spatial intensity distribution analysis quantifies the extent and regulation of homodimerization of the secretin receptor Biochemical Journal, 474, pp. 1879-1895. (doi: 10.1042/BCJ20170184)

Kaspersen, M. H., Jenkins, L., Dunlop, J., Milligan, G., Ulven, T. (2017) Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84 MedChemComm, 8, pp. 1360-1365. (doi: 10.1039/c7md00130d)

Vialet-Chabrand, S. R.M., Matthews, J. S.A., McAusland, L., Blatt, M. R., Griffiths, H., Lawson, T. (2017) Temporal dynamics of stomatal behavior: modeling and implications for photosynthesis and water use Plant Physiology, 174, pp. 603-613. (doi: 10.1104/pp.17.00125)

Jezek, M., Blatt, M. R. (2017) The membrane transport system of the guard cell and its integration for stomatal dynamics Plant Physiology, 174, pp. 487-519. (doi: 10.1104/pp.16.01949)

Salt, I. P., Hardie, G. (2017) AMP-activated protein kinase: an ubiquitous signalling pathway with key roles in the cardiovascular system Circulation Research, 120, pp. 1825-1841. (doi: 10.1161/CIRCRESAHA.117.309633)

Marsango, S., Caltabiano, G., Jiménez-Rosés, M., Millan, M. J., Pediani, J. D., Ward, R. J., Milligan, G. (2017) A molecular basis for selective antagonist destabilization of dopamine D3 receptor quaternary organization Scientific Reports, 7, (doi: 10.1038/s41598-017-02249-3)

Carmody, R., Keeshan, K. (2017) The Tribble with APL: a new road to therapy Cancer Cell, 31, pp. 612-613. (doi: 10.1016/j.ccell.2017.04.011)

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Tanaka, M., Ishizuka, K., Nekooki-Machida, Y., Endo, R., Takashima, N., Sasaki, H., Komi, Y., Gathercole, A., Huston, E., Ishii, K., Hui, K. K.-W., Kurosawa, M., Kim, S.-H., Nukina, N., Takimoto, E., Houslay, M. D., Sawa, A. (2017) Aggregation of scaffolding protein DISC1 dysregulates phosphodiesterase 4 in Huntington’s disease Journal of Clinical Investigation, 127, pp. 1438-1450. (doi: 10.1172/JCI85594)

Brandani, G. B., Vance, S. J., Schor, M., Cooper, A., Kennedy, M. W., Smith, B. O., MacPhee, C. E., Cheung, D. L. (2017) Adsorption of the natural protein surfactant Rsn-2 onto liquid interfaces Physical Chemistry Chemical Physics, 19, pp. 8584-8594. (doi: 10.1039/C6CP07261E)

Parnell, E., McElroy, S. P., Wiejak, J., Baillie, G. L., Porter, A., Adams, D. R., Rehmann, H., Smith, B. O., Yarwood, S. J. (2017) Identification of a novel, small molecule partial agonist for the cyclic AMP sensor, EPAC1 Scientific Reports, 7, (doi: 10.1038/s41598-017-00455-7)

Ahmed, A., Wan, X., Mitxitorena, I., Lindsay, A. J., Pandolfi, P. P., McCaffrey, M. W., Keeshan, K., Chen, Y. H., Carmody, R. J. (2017) Regulation of NF-κB by PML and PML-RARα Scientific Reports, 7, (doi: 10.1038/srep44539)

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Mackenzie, A. E., Milligan, G. (2017) The emerging pharmacology and function of GPR35 in the nervous system Neuropharmacology, 113, pp. 661-671. (doi: 10.1016/j.neuropharm.2015.07.035)

Mancini, S. J., White, A. D., Bijland, S., Rutherford, C., Graham, D., Richter, E. A., Viollet, B., Touyz, R. M., Palmer, T. M., Salt, I. P. (2017) Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptorassociated kinase-4 phosphorylation Molecular and Cellular Endocrinology, 440, pp. 44-56. (doi: 10.1016/j.mce.2016.11.010)

Chen, S. C., Brooks, R., Houskeeper, J., Bremner, S. K., Dunlop, J., Viollet, B., Logan, P. J., Salt, I. P., Ahmed, S. F., Yarwood, S. J. (2017) Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms Molecular and Cellular Endocrinology, 440, pp. 57-68. (doi: 10.1016/j.mce.2016.11.011)

Karnik, R., Waghmare, S., Zhang, B., Larson, E., Lefoulon, C., Gonzalez, W., Blatt, M. R. (2017) Commandeering channel voltage sensors for secretion, cell turgor, and volume control Trends in Plant Science, 22, pp. 81-95. (doi: 10.1016/j.tplants.2016.10.006)

Zhang, B., Karnik, R., Waghmare, S., Donald, N. A., Blatt, M. R. (2017) VAMP721 conformations unmask an extended motif for K+ channel binding and gating control Plant Physiology, 173, pp. 536-551. (doi: 10.1104/pp.16.01549)

Milligan, G., Shimpukade, B., Ulven, T., Hudson, B. D. (2017) Complex pharmacology of free fatty acid receptors Chemical Reviews, 117, pp. 67-110. (doi: 10.1021/acs.chemrev.6b00056)

Hansen, A. H., Sergeev, E., Pandey, S. K., Hudson, B. D., Christiansen, E., Milligan, G., Ulven, T. (2017) Development and characterization of a fluorescent tracer for the free fatty acid receptor 2 (FFA2/GPR43) Journal of Medicinal Chemistry, 60, pp. 5638-5645. (doi: 10.1021/acs.jmedchem.7b00338)

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Alvarez-Curto, E., Inoue, A., Jenkins, L., Raihan, S. Z., Prihandoko, R., Tobin, A. B., Milligan, G. (2016) Targeted elimination of G proteins and arrestins defines their specific contributions to both intensity and duration of G protein-coupled receptor signalling Journal of Biological Chemistry, 291, pp. 27147-27159. (doi: 10.1074/jbc.M116.754887)

Docherty, C. K., Salt, I. P., Mercer, J. R. (2016) Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells Stem Cell Research and Therapy, 7, (doi: 10.1186/s13287-016-0323-2)

Heathcote, H. R., Mancini, S. J., Strembitska, A., Jamal, K., Reihill, J. A., Palmer, T. M., Gould, G. W., Salt, I. P. (2016) Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487 Biochemical Journal, 473, pp. 4681-4697. (doi: 10.1042/BCJ20160211)

Li, H., Bogyo, M., da Fonseca, P. C.A. (2016) The cryo-EM structure of thePlasmodium falciparum20S proteasome and its use in the fight against malaria FEBS Journal, 283, pp. 4238-4243. (doi: 10.1111/febs.13780)

Rutherford, C., Speirs, C., Williams, J. J.L., Ewart, M.-A., Mancini, S. J., Hawley, S. A., Delles, C., Viollet, B., Costa-Pereira, A. P., Baillie, G. S., Salt, I. P., Palmer, T. M. (2016) Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling Science Signaling, 9, (doi: 10.1126/scisignal.aaf8566)

Grinter, R., Josts, I., Mosbahi, K., Roszak, A. W., Cogdell, R. J., Bonvin, A. M.J.J., Milner, J. J., Kelly, S. M., Byron, O., Smith, B. O., Walker, D. (2016) Structure of the bacterial plant-ferredoxin receptor FusA Nature Communications, 7, (doi: 10.1038/ncomms13308)

Hudson, B. D. (2016) Using biosensors to study free fatty acid receptor pharmacology and function Springer

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Vialet-Chabrand, S., Matthews, J. S. A., Brendel, O., Blatt, M.R., Wang, Y., Hills, A., Griffiths, H., Rogers, S., Lawson, T. (2016) Modelling water use efficiency in a dynamic environment: an example using Arabidopsis thaliana Plant Science, 251, pp. 65-74. (doi: 10.1016/j.plantsci.2016.06.016)

Heilmann, M., Velanis, C. N., Cloix, C., Smith, B. O., Christie, J. M., Jenkins, G. I. (2016) Dimer/monomer status and in vivo function of salt-bridge mutants of the plant UV-B photoreceptor UVR8 Plant Journal, 88, pp. 71-81. (doi: 10.1111/tpj.13260)

Bolognini, D., Moss, C. E., Nilsson, K., Petersson, A. U., Donnelly, I., Sergeev, E., König, G. M., Kostenis, E., Kurowska-Stolarska, M., Miller, A., Dekker, N., Tobin, A. B., Milligan, G. (2016) A novel allosteric activator of free fatty acid 2 receptor displays unique Gi-functional bias Journal of Biological Chemistry, 291, pp. 18915-18931. (doi: 10.1074/jbc.M116.736157)

Hawley, S. A., Ford, R. J., Smith, B. K., Gowans, G. J., Mancini, S., Pitt, R. D., Day, E. A., Salt, I. P., Steinberg, G. R., Hardie, D. G. (2016) The Na+ glucose co-transporter inhibitor canagliflozin activates AMP-activated protein kinase by inhibiting mitochondrial function and increasing cellular AMP levels Diabetes, 65, pp. 2784-2794. (doi: 10.2337/db16-0058)

Papanatsiou, M., Amtmann, A., Blatt, M. R. (2016) Stomatal spacing safeguards stomatal dynamics by facilitating guard cell ion transport independent of the epidermal solute reservoir Plant Physiology, 172, pp. 254-263. (doi: 10.1104/pp.16.00850)

Liang, K. L., Paredes, R., Carmody, R., Eyers, P. A., Meyer, S., McCarthy, T. V., Keeshan, K. (2016) Human TRIB2 oscillates during the cell cycle and promotes ubiquitination and degradation of CDC25C International Journal of Molecular Sciences, 17, (doi: 10.3390/ijms17091378)

Morris, R. J., Brandani, G. B., Desai, V., Smith, B. O., Schor, M., MacPhee, C. E. (2016) The conformation of interfacially adsorbed Ranaspumin-2 Is an arrested state on the unfolding pathway Biophysical Journal, 111, pp. 732-742. (doi: 10.1016/j.bpj.2016.06.006)

Alvarez-Curto, E., Milligan, G. (2016) Metabolism meets immunity: the role of free fatty acid receptors in the immune system Biochemical Pharmacology, 114, pp. 3-13. (doi: 10.1016/j.bcp.2016.03.017)

Dean, A., Nilsen, M., Loughlin, L., Salt, I. P., MacLean, M. R. (2016) Metformin reverses development of pulmonary hypertension via aromatase inhibition Hypertension, 68, pp. 446-454. (doi: 10.1161/HYPERTENSIONAHA.116.07353)

Vance, S. J., Desai, V., Smith, B. O., Kennedy, M. W., Cooper, A. (2016) Aqueous solubilization of C60 fullerene by natural protein surfactants, latherin and ranaspumin-2 Biophysical Chemistry, 214-15, pp. 27-32. (doi: 10.1016/j.bpc.2016.05.003)

Pediani, J. D., Ward, R. J., Godin, A. G., Marsango, S., Milligan, G. (2016) Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs Journal of Biological Chemistry, 291, pp. 13132-13146. (doi: 10.1074/jbc.M115.712562)

Ashraf, K. U., Josts, I., Mosbahi, K., Kelly, S. M., Byron, O., Smith, B. O., Walker, D. (2016) The potassium binding protein Kbp is a cytoplasmic potassium sensor Structure, 24, pp. 741-749. (doi: 10.1016/j.str.2016.03.017)

Nuber, S., Zabel, U., Lorenz, K., Nuber, A., Milligan, G., Tobin, A. B., Lohse, M. J., Hoffmann, C. (2016) β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle Nature, 531, pp. 661-664. (doi: 10.1038/nature17198)

Hansen, S. V.F., Christiansen, E., Urban, C., Hudson, B. D., Stocker, C. J., Due-Hansen, M. E., Wargent, E. T., Shimpukade, B., Almeida, R., Ejsing, C. S., Cawthorne, M. A., Kassack, M. U., Milligan, G., Ulven, T. (2016) Discovery of a potent free fatty acid 1 receptor agonist with low lipophilicity, low polar surface area and robust in vivo efficacy Journal of Medicinal Chemistry, 59, pp. 2841-2846. (doi: 10.1021/acs.jmedchem.5b01962)

Grundmann, M., Tikhonova, I. G., Hudson, B. D., Smith, N. J., Mohr, K., Ulven, T., Milligan, G., Kenakin, T., Kostenis, E. (2016) A molecular mechanism for sequential activation of a G Protein-coupled receptor Cell Chemical Biology, 23, pp. 392-403. (doi: 10.1016/j.chembiol.2016.02.014)

Pratt, A. G., Anderson, A. E., Carmody, R. J., Isaacs, J. D. (2016) B cell lymphoma 3 (Bcl-3) in CD4+ T cell mediated RA pathogenesis: Comment on the article by Meguro et al. Arthritis and Rheumatology, 68, pp. 770-771. (doi: 10.1002/art.39509)

Herrington, F. D., Carmody, R. J., Goodyear, C. S. (2016) Modulation of NF-κB signaling as a therapeutic target in autoimmunity Journal of Biomolecular Screening, 21, pp. 223-242. (doi: 10.1177/1087057115617456)

Chen, Z.-H., Wang, Y., Wang, J.-W., Babla, M., Zhao, C., Garcia-Mata, C., Sani, E., Differ, C., Mak, M., Hills, A., Amtmann, A., Blatt, M. R. (2016) Nitrate reductase mutation alters potassium nutrition as well as nitric oxide-mediated control of guard cell ion channels in Arabidopsis New Phytologist, 209, pp. 1456-1469. (doi: 10.1111/nph.13714)

Bolognini, D., Tobin, A. B., Milligan, G., Moss, C. E. (2016) The pharmacology and function of receptors for short-chain fatty acids Molecular Pharmacology, 89, pp. 388-398. (doi: 10.1124/mol.115.102301)

Li, H., O’Donoghue, A. J., van der Linden, W. A., Xie, S. C., Yoo, E., Foe, I. T., Tilley, L., Craik, C. S., da Fonseca, P. C.A., Bogyo, M. (2016) Structure- and function-based design of Plasmodium-selective proteasome inhibitors Nature, 530, pp. 233-236. (doi: 10.1038/nature16936)

Blatt, M. R. (2016) Plant physiology: redefining the enigma of metabolism in stomatal movement Current Biology, 26, pp. R107-R109. (doi: 10.1016/j.cub.2015.12.025)

Moreno, J. L., Miranda-Azpiazu, P., Garcia-Bea, A., Younkin, J., Cui, M., Kozlenkov, A., Ben-Ezra, A., Voloudakis, G., Fakira, A. K., Baki, L., Ge, Y., Georgakopoulos, A., Moron, J. A., Milligan, G., Lopez-Gimenez, J. F., Robakis, N. K., Logothetis, D. E., Meana, J. J., Gonzalez-Maeso, J. (2016) Allosteric signaling through an mGlu2 and 5-HT2A heteromeric receptor complex and its potential contribution to schizophrenia Science Signaling, 9, pp. ra5. (doi: 10.1126/scisignal.aab0467)

Minguet-Parramona, C., Wang, Y., Hills, A., Vialet-Chabrand, S., Griffiths, H., Rogers, S., Lawson, T., Lew, V. L., Blatt, M. R. (2016) An optimal frequency in Ca2+ oscillations for stomatal closure is an emergent property of ion transport in guard cells Plant Physiology, 170, pp. 33-42. (doi: 10.1104/pp.15.01607)

Sergeev, E., Hansen, A. H., Pandey, S. K., MacKenzie, A. E., Hudson, B. D., Ulven, T., Milligan, G. (2016) Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands Journal of Biological Chemistry, 291, pp. 303-317. (doi: 10.1074/jbc.M115.687939)

Christiansen, E., Hudson, B. D., Hansen, A. H., Milligan, G., Ulven, T. (2016) Development and characterization of a potent free fatty acid receptor 1 (FFA1) fluorescent tracer Journal of Medicinal Chemistry, 59, pp. 4849-4858. (doi: 10.1021/acs.jmedchem.6b00202)

Prihandoko, R., Alvarez-Curto, E., Hudson, B. D., Butcher, A. J., Ulven, T., Miller, A. M., Tobin, A. B., Milligan, G. (2016) Distinct phosphorylation clusters determines the signalling outcome of the free fatty acid receptor FFA4/GPR120 Molecular Pharmacology, 89, pp. 505-520. (doi: 10.1124/mol.115.101949)

McCallum, J. E., Mackenzie, A. E., Divorty, N., Clarke, C., Delles, C., Milligan, G., Nicklin, S. A. (2016) G protein-coupled receptor 35 mediates human saphenous vein vascular smooth muscle cell migration and endothelial cell proliferation Journal of Vascular Research, 52, pp. 383-395. (doi: 10.1159/000444754)

Schrage, R., Schmitz, A.-L., Gaffal, E., Annala, S., Kehraus, S., Wenzel, D., Büllesbach, K. M., Bald, T., Inoue, A., Shinjo, Y., Galandrin, S., Shridhar, N., Hesse, M., Grundmann, M., Merten, N., Charpentier, T. H., Martz, M., Butcher, A. J., Slodczyk, T., Armando, S., Effern, M., Namkung, Y., Jenkins, L., Horn, V., Stößel, A., Dargatz, H., Tietze, D., Imhof, D., Galés, C., Drewke, C., Müller, C. E., Hölzel, M., Milligan, G., Tobin, A. B., Gomeza, J., Dohlman, H. G., Sondek, J., Harden, T. K., Bouvier, M., Laporte, S. A., Aoki, J., Fleischmann, B. K., Mohr, K., König, G. M., Tüting, T., Kostenis, E. (2015) The experimental power of FR900359 to study Gq-regulated biological processes Nature Communications, 6, pp. 10156. (doi: 10.1038/ncomms10156)

Rey, B. M.F., Ibáñez, S. M., Gabrielsen, M., Franchini, G. R., Roe, A. J., Griffiths, K., Zhan, B., Cooper, A., Kennedy, M. W., Córsico, B., Smith, B. O. (2015) Diversity in the structures and ligand binding sites of nematode fatty acid and retinol binding proteins revealed by Na-FAR-1 from Necator americanus Biochemical Journal, 471, pp. 403-414. (doi: 10.1042/BJ20150068)

Thomson, R., Smith, B. O. (2015) Solution structure of human MBD1 CXXC1 Journal of Biomolecular NMR, 63, pp. 309-314. (doi: 10.1007/s10858-015-9986-8)

Ning, Z., McLellan, A. S., Ball, M., Wynne, F., O'Neill, C., Mills, W., Quinn, J. P., Kleinjan, D. A., Anney, R. J., Carmody, R., O'Keeffe, G., Moore, T. (2015) Regulation of SPRY3 by X chromosome and PAR2-linked promoters in an autism susceptibility region Human Molecular Genetics, 24, pp. 5126-5141. (doi: 10.1093/hmg/ddv231)

Grefen, C., Karnik, R., Larson, E., Lefoulon, C., Wang, Y., Waghmare, S., Zhang, B., Hills, A., Blatt, M. R. (2015) A vesicle-trafficking protein commandeers Kv channel voltage sensors for voltage-dependent secretion Nature Plants, 1, (doi: 10.1038/nplants.2015.108)

da Fonseca, P. C.A., Morris, E. P. (2015) Cryo-EM reveals the conformation of a substrate analogue in the human 20S proteasome core Nature Communications, 6, (doi: 10.1038/ncomms8573)

Mckinney, C.A., Kennedy, S., Baillie, G.S., Milligan, G., Nicklin, S.A. (2015) Angiotensin-(1-7) and angiotensin-(1-9) inhibit vascular smooth muscle cell growth and migration in vitro and vascular remodelling in vivo Atherosclerosis, 241, pp. e44. (doi: 10.1016/j.atherosclerosis.2015.04.158)

Milligan, G., Alvarez-Curto, E., Watterson, K.R., Ulven, T., Hudson, B.D. (2015) Characterizing pharmacological ligands to study the long-chain fatty acid receptors GPR40/FFA1 and GPR120/FFA4 British Journal of Pharmacology, 172, pp. 3254-3265. (doi: 10.1111/bph.12879)

Brown, J.H., Catterall, W.A., Conn, P.J., Cull-Candy, S.G., Dingledine, R., Harden, T.K., Insel, P.A., Milligan, G., Traynelis, S.F. (2015) The first 50 years of molecular pharmacology Molecular Pharmacology, 88, pp. 139-140. (doi: 10.1124/mol.115.099564)

Collins, P. E., Grassia, G., Colleran, A., Kiely, P. A., Ialenti, A., Maffia, P., Carmody, R. J. (2015) Mapping the interaction of B cell Leukemia 3 (BCL-3) and nuclear factor κB (NF-κB) p50 identifies a BCL-3-mimetic anti-inflammatory peptide Journal of Biological Chemistry, 290, pp. 15687-15696. (doi: 10.1074/jbc.M115.643700)

Marsango, S., Caltabiano, G., Pou, C., Varela Liste, M. J., Milligan, G. (2015) Analysis of human dopamine D3 receptor quaternary structure Journal of Biological Chemistry, 290, pp. 15146-15162. (doi: 10.1074/jbc.M114.630681)

Milligan, G., Liste, M. J. V., Caltabiano, G. C., Alvarez-Curto, E., Marsango, S. (2015) Defining the organizational structure of dopamine and muscarninic acetylcholine receptors SpringerPlus, 4, (doi: 10.1186/2193-1801-4-s1-l7)

Aslanoglou, D., Alvarez-Curto, E., Marsango, S., Milligan, G. (2015) Distinct agonist regulation of muscarinic acetylcholine M2-M3 heteromers and their corresponding homomers Journal of Biological Chemistry, 290, pp. 14785-14796. (doi: 10.1074/jbc.M115.649079)

Christiansen, E., Watterson, K.R., Stocker, C.J., Sokol, E., Jenkins, L., Simon, K., Grundmann, M., Petersen, R.K., Wargent, E.T., Hudson, B.D., Kostenis, E., Ejsing, C.S., Cawthorne, M.A., Milligan, G., Ulven, T. (2015) Activity of dietary fatty acids on FFA1 and FFA4 and characterisation of pinolenic acid as a dual FFA1/FFA4 agonist with potential effect against metabolic diseases British Journal of Nutrition, 113, pp. 1677-1688. (doi: 10.1017/S000711451500118X)

Zhang, B., Karnik, R., Wang, Y., Wallmeroth, N., Blatt, M. R., Grefen, C. (2015) The arabidopsis R-SNARE VAMP721 interacts with KAT1 and KC1 K+ channels to moderate K+ current at the plasma membrane Plant Cell, 27, pp. 1697-1717. (doi: 10.1105/tpc.15.00305)

Liste, M. J., Caltabiano, G., Ward, R. J., Alvarez-Curto, E., Marsango, S., Milligan, G. (2015) The molecular basis of oligomeric organization of the human m3 muscarinic acetylcholine receptor Molecular Pharmacology, 87, pp. 936-953. (doi: 10.1124/mol.114.096925)

Papanatsiou, M., Scuffi, D., Blatt, M. R., Garia-Mata, C. (2015) Hydrogen sulphide regulates inward-rectifying K+ channels in conjunction with stomatal closure Plant Physiology, 168, pp. 29-35. (doi: 10.1104/pp.114.256057)

Ward, R. J., Pediani, J. D., Godin, A. G., Milligan, G. (2015) Regulation of oligomeric organization of the serotonin 5-hydroxytryptamine 2C (5-HT2C) receptor observed by spatial intensity distribution analysis Journal of Biological Chemistry, 290, pp. 12844-12857. (doi: 10.1074/jbc.M115.644724)

Parnell, E., Smith, B. O., Yarwood, S. J. (2015) The cAMP sensors, EPAC1 and EPAC2, display distinct subcellular distributions despite sharing a common nuclear pore localisation signal Cellular Signalling, 27, pp. 989-996. (doi: 10.1016/j.cellsig.2015.02.009)

Buetow, L., Gabrielsen, M., Anthony, N. G., Dou, H., Patel, A., Aitkenhead, H., Sibbet, G. J., Smith, B. O., Huang, D. T. (2015) Activation of a primed RING E3-E2–ubiquitin complex by non-covalent ubiquitin Molecular Cell, 58, pp. 297-310. (doi: 10.1016/j.molcel.2015.02.017)

DeLeeuw, J., Weir, J., Copsey, D., Roden, C., Deeley, S., Huston, E., McVey, M., Finlay, C. (2015) Developing Graduate Attributes and Improving Student Employability Through Work-based Learning: Opportunities, Successes and Challenges

Karnik, R., Zhang, B., Waghmare, S., Aderhold, C., Grefen, C., Blatt, M. R. (2015) Binding of SEC11 indicates its role in SNARE recycling after vesicle fusion and identifies two pathways for vesicular traffic to the plasma membrane Plant Cell, 27, pp. 675-694. (doi: 10.1105/tpc.114.134429)

Shigemitsu, Y., Ikeya, T., Yamamoto, A., Tsuchie, Y., Mishima, M., Smith, B. O., Güntert, P., Ito, Y. (2015) Evaluation of the reliability of the maximum entropy method for reconstructing 3D and 4D NOESY-type NMR spectra of proteins Biochemical and Biophysical Research Communications, 457, pp. 200-205. (doi: 10.1016/j.bbrc.2014.12.088)

Franchini, G. R., Pórfido, J. L., Ibáñez Shimabukuro, M., Rey Burusco, M. F., Bélgamo, J. A., Smith, B. O., Kennedy, M. W., Córsico, B. (2015) The unusual lipid binding proteins of parasitic helminths and their potential roles in parasitism and as therapeutic targets Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA), 93, pp. 31-36. (doi: 10.1016/j.plefa.2014.08.003)

Choudhury, Y., Salt, I., Leung, H. (2015) AMPK—friend or foe for targeted therapy? Cell Cycle, 14, pp. 1761-1762. (doi: 10.1080/15384101.2015.1022066)

Marsango, S., Varela, M. J., Milligan, G. (2015) Approaches to characterize and quantify oligomerization of GPCRs Springer New York

Colleran, A., Collins, P. E., Carmody, R. J. (2015) Assessing sites of NF-κB DNA binding using chromatin immunoprecipitation. Humana Press

Collins, P. E., Colleran, A., Carmody, R. J. (2015) Control of NF-κB subunits by ubiquitination Humana Press

Alvarez-Curto, E., Milligan, G. (2015) Defining the functional equivalence of wild-type and chemically engineered G protein-coupled receptors Springer New York

Divorty, N., Mackenzie, A., Nicklin, S., Milligan, G. (2015) G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease Frontiers in Pharmacology, 6, (doi: 10.3389/fphar.2015.00041)

Collins, P. E., O'Carroll, C., Carmody, R. J. (2015) Measurement of NF-κB transcriptional activity and identification of NF-κB cis-regulatory elements using luciferase assays Humana Press

Mathes, T., Heilmann, M., Pandit, A., Zhu, J., Ravensbergen, J., Kloz, M., Fu, Y., Smith, B.O., Christie, J.M., Jenkins, G.I., Kennis, J.T.M. (2015) Proton-coupled electron transfer constitutes the photoactivation mechanism of the plant photoreceptor UVR8 Journal of the American Chemical Society, 137, pp. 8113-8120. (doi: 10.1021/jacs.5b01177)

Collins, P. E., Carmody, R. J. (2015) The regulation of endotoxin tolerance and its impact on macrophage activation Critical Reviews in Immunology, 35, pp. 293-323. (doi: 10.1615/CritRevImmunol.2015015495)

Lefoulon, C., Karnik, R., Honsbein, A., Gutla, P. V., Grefen, C., Riedelsberger, J., Poblete, T., Dreyer, I., Gonzalez, W., Blatt, M. R. (2014) Voltage-sensor transitions of the inward-rectifying K+ channel KAT1 indicate a latching mechanism biased by hydration within the voltage sensor Plant Physiology, 166, pp. 960-975. (doi: 10.1104/pp.114.244319)

Sheppard, C. L., Lee, L. C.Y., Hill, E. V., Henderson, D. J.P., Anthony, D. F., Houslay, D. M., Yalla, K. C., Cairns, L. S., Dunlop, A. J., Baillie, G. S., Huston, E., Houslay, M. D. (2014) Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression Cellular Signalling, 26, pp. 1958-1974. (doi: 10.1016/j.cellsig.2014.04.023)

Hudson, B. D., Christiansen, E., Murdoch, H., Jenkins, L., Hansen, A. H., Madsen, O., Ulven, T., Milligan, G. (2014) Complex pharmacology of novel allosteric free fatty acid 3 receptor ligands Molecular Pharmacology, 86, pp. 200-210. (doi: 10.1124/mol.114.093294)

Hachez, C., Laloux, T., Reinhardt, H., Cavez, D., Degand, H., Grefen, C., De Rycke, R., Inze, D., Blatt, M. R., Russinova, E., Chaumont, F. (2014) Arabidopsis SNAREs SYP61 and SYP121 coordinate the trafficking of plasma membrane aquaporin PIP2;7 to modulate the cell membrane water permeability Plant Cell, 26, pp. 3132-3147. (doi: 10.1105/tpc.114.127159)

Hudson, B. D., Shimpukade, B., Milligan, G., Ulven, T. (2014) The molecular basis of ligand interaction at free fatty acid receptor 4 (FFA4/GPR120) Journal of Biological Chemistry, 289, pp. 20345-20358. (doi: 10.1074/jbc.M114.561449)

Zakrys, L., Ward, R. J., Pediani, J. D., Godin, A. G., Graham, G. J., Milligan, G. (2014) Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2 Biochemical Journal, 461, pp. 61-73. (doi: 10.1042/BJ20140190)

Beckham, K. S.H., Connolly, J. P.R., Ritchie, J. M., Wang, D., Gawthorne, J. A., Tahoun, A., Gally, D. L., Burgess, K., Burchmore, R. J., Smith, B. O., Beatson, S. A., Byron, O., Wolfe, A. J., Douce, G., Roe, A. J. (2014) The metabolic enzyme AdhE controls the virulence of Escherichia coli O157:H7 Molecular Microbiology, 93, pp. 199-211. (doi: 10.1111/mmi.12651)

Cameron, R. T., Quinn, S. D., Cairns, L. S., MacLeod, R., Samuel, I. D.W., Smith, B. O., Penedo, J. C., Baillie, G. S. (2014) The phosphorylation of Hsp20 enhances its association with amyloid-β to increase protection against neuronal cell death Molecular and Cellular Neuroscience, 61, pp. 46-55. (doi: 10.1016/j.mcn.2014.05.002)

Butcher, A. J., Hudson, B. D., Shimpukade, B., Alvarez-Curto, E., Prihandoko, R., Ulven, T., Milligan, G., Tobin, A. B. (2014) Concomitant action of structural elements and receptor phosphorylation determine arrestin-3 interaction with the free fatty acid receptor FFA4 Journal of Biological Chemistry, 289, pp. 18451-18465. (doi: 10.1074/jbc.M114.568816)

Fjaere, E., Aune, U. L., Roen, K., Keenan, A. H., Ma, T., Borkowski, K., Kristensen, D. M., Novotny, G. W., Mandrup-Poulsen, T., Hudson, B. D., Milligan, G., Xi, Y., Newman, J. W., Haj, F. G., Liaset, B., Kristiansen, K., Madsen, L. (2014) Indomethacin treatment prevents high fat diet-induced obesity and insulin resistance but not glucose intolerance in C57BL/6J mice Journal of Biological Chemistry, 289, pp. 16032-16045. (doi: 10.1074/jbc.M113.525220)

Choudhury, Y., Yang, Z., Ahmad, I., Nixon, C., Salt, I. P., Leung, H. Y. (2014) AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer Oncoscience, 1, pp. 446-456. (doi: 10.18632/oncoscience.49)

McKinney, C. A., Fattah, C., Loughrey, C. M., Milligan, G., Nicklin, S. A. (2014) Angiotensin-(1-7) and angiotensin-(1-9): function in cardiac and vascular remodeling Clinical Science, 126, pp. 815-827. (doi: 10.1042/CS20130436)

Milligan, G., Ulven, T., Murdoch, H., Hudson, B. D. (2014) G-protein-coupled receptors for free fatty acids: nutritional and therapeutic targets British Journal of Nutrition, 111, pp. S3-S7. (doi: 10.1017/S0007114513002249)

Blatt, M. R., Wang, Y., Leonhardt, N., Hills, A. (2014) Exploring emergent properties in cellular homeostasis using OnGuard to model K+ and other ion transport in guard cells Journal of Plant Physiology, 171, pp. 770-778. (doi: 10.1016/j.jplph.2013.09.014)

Eisenach, C., Papanatsiou, M., Hillert, E.-K., Blatt, M. R. (2014) Clustering of the K⁺ channel GORK of Arabidopsis parallels its gating by extracellular K⁺ Plant Journal, 78, pp. 203-214. (doi: 10.1111/tpj.12471)

Ibáñez-Shimabukuro, M., Rey-Burusco, M.F., Cooper, A., Kennedy, M. W., Córsico, B., Smith, B. O. (2014) Resonance assignment of As-p18, a fatty acid binding protein secreted by developing larvae of the parasitic nematode Ascaris suum Biomolecular NMR Assignments, 8, pp. 33-36. (doi: 10.1007/s12104-012-9447-1)

Blatt, M. R., Chaumont, F., Farquhar, G. (2014) Focus on water Plant Physiology, 164, pp. 1553-1555. (doi: 10.1104/pp.114.900484)

Ferre, S., Casado, V., Devi, L. A., Filizola, M., Jockers, R., Lohse, M. J., Milligan, G., Pin, J.-P., Guitart, X. (2014) G protein-coupled receptor oligomerization revisited: functional and pharmacological perspectives Pharmacological Reviews, 66, pp. 413-434. (doi: 10.1124/pr.113.008052)

Vance, S. J., McDonald, R. E., Cooper, A., Kennedy, M. W., Smith, B. O. (2014) Resonance assignments for latherin, a natural surfactant protein from horse sweat Biomolecular NMR Assignments, 8, pp. 213-216. (doi: 10.1007/s12104-013-9485-3)

Lawson, T., Blatt, M. R. (2014) Stomatal size, speed, and responsiveness impact on photosynthesis and water use efficiency Plant Physiology, 164, pp. 1556-1570. (doi: 10.1104/pp.114.237107)

Wang, Y., Hills, A., Blatt, M. (2014) Systems analysis of guard cell membrane transport for enhanced stomatal dynamics and water use efficiency Plant Physiology, 164, pp. 1593-1599. (doi: 10.1104/pp.113.233403)

Yvon, C., Surman, A. J., Hutin, M., Alex, J., Smith, B. O., Long, D. L., Cronin, L. (2014) Polyoxometalate clusters integrated into peptide chains and as inorganic amino acids: solution- and solid-phase approaches Angewandte Chemie (International Edition), 53, pp. 3336-3341. (doi: 10.1002/anie.201311135)

Collins, P. E., Kiely, P. A., Carmody, R. J. (2014) Inhibition of transcription by B cell leukaemia 3 (Bcl-3) requires interaction with nuclear factor (NF)-κB p50 Journal of Biological Chemistry, 289, pp. 7059-7067. (doi: 10.1074/jbc.M114.551986)

Rey-Burusco, M.F., Ibañez-Shimabukuro, M., Cooper, A., Kennedy, M. W., Córsico, B., Smith, B. O. (2014) 1H, 13C and 15N chemical shift assignments of Na-FAR-1, a helix-rich fatty acid and retinol binding protein of the parasitic nematode Necator americanus Biomolecular NMR Assignments, 8, pp. 19-21. (doi: 10.1007/s12104-012-9444-4)

Gehl, B., Lee, C. P., Bota, P., Blatt, M. R., Sweetlove, L. J. (2014) An arabidopsis stomatin-like protein affects mitochondrial respiratory supercomplex organization Plant Physiology, 164, pp. 1389-1400. (doi: 10.1104/pp.113.230383)

Almabrouk, T.A.M., Ewart, M.-A., Salt, I.P., Kennedy, S. (2014) Perivascular fat, AMP-activated protein kinase and vascular diseases British Journal of Pharmacology, 171, pp. 595-617. (doi: 10.1111/bph.12479)

McCaughey, L. C., Grinter, R., Josts, I., Roszak, A. W., Waløen, K., Cogdell, R. J., Milner, J., Evans, T., Kelly, S., Tucker, N. P., Byron, O., Smith, B., Walker, D. (2014) Lectin-like bacteriocins from Pseudomonas spp. utilise D-rhamnose containing lipopolysaccharide as a cellular receptor PLoS Pathogens, 10, pp. e1003898. (doi: 10.1371/journal.ppat.1003898)

Caldwell, S.T., Maclean, C., Riehle, M., Cooper, A., Nutley, M., Rabani, G., Fitzpatrick, B., Rotello, V.M., Smith, B.O., Khaled, B., Woisel, P., Cooke, G. (2014) Protein-mediated dethreading of a biotin-functionalised pseudorotaxane Organic and Biomolecular Chemistry, 12, pp. 511-516. (doi: 10.1039/C3OB41612G)

Ward, R.J., Milligan, G. (2014) Structural and biophysical characterisation of G protein-coupled receptor ligand binding using resonance energy transfer and fluorescent labelling techniques Biochimica et Biophysica Acta: Biomembranes, 1838, pp. 3-14. (doi: 10.1016/j.bbamem.2013.04.007)

O'Carroll, C., Fagan, A., Shanahan, F., Carmody, R.J. (2014) Identification of a unique hybrid macrophage-polarization state following recovery from lipopolysaccharide tolerance Journal of Immunology, 192, pp. 427-436. (doi: 10.4049/jimmunol.1301722)

Christie, J., Blatt, M. (2014) Plant physiology sees the light Plant Physiology, 164, pp. 12. (doi: 10.1104/pp.113.900477)

Mackenzie, A.E., Caltabiano, G., Kent, T.C., Jenkins, L., McCallum, J.E., Hudson, B.D., Nicklin, S.A., Fawcett, L., Markwick, R., Charlton, S.J., Milligan, G. (2014) The antiallergic mast cell stabilizers lodoxamide and bufrolin as the first high and equipotent agonists of human and rat gpr35 Molecular Pharmacology, 85, pp. 91-104. (doi: 10.1124/mol.113.089482)

Blatt, M. R., Grefen, C. (2014) Applications of fluorescent marker proteins in plant cell biology Humana Press

Williams, M. T.S., Yousafzai, Y., Cox, C., Blair, A., Carmody, R., Sai, S., Chapman, K. E., McAndrew, R., Thomas, A., Spence, A., Gibson, B., Graham, G., Halsey, C. (2014) Interleukin-15 enhances cellular proliferation and up-regulates CNS homing molecules in pre-B acute lymphoblastic leukemia Blood, 123, pp. 3116-3127. (doi: 10.1182/blood-2013-05-499970)

Salt, I.P., Harnett, M.M., Goodridge, H.S. (2014) Membrane receptors and signal transduction Saunders Elsevier

Josts, I., Grinter, R., Kelly, S. M., Mosbahi, K., Roszak, A., Cogdell, R., Smith, B. O., Byron, O., Walker, D. (2014) Recombinant expression, purification, crystallization and preliminary X-ray diffraction analysis of the C-terminal DUF490963–1138 domain of TamB from Escherichia coli Acta Crystallographica. Section F: Structural Biology Communications, 70, pp. 1272-1275. (doi: 10.1107/S2053230X14017403)

Watterson, K. R., Hudson, B. D., Ulven, T., Milligan, G. (2014) Treatment of type 2 diabetes by free fatty acid receptor agonists Frontiers in Endocrinology, 5, (doi: 10.3389/fendo.2014.00137)