School of Molecular Biosciences

Alshammari, W.S., Duncan, E.M., Vita, L., Kenawy, M., Dibnah, B., Wabitsch, M., Gould, G.W., Hudson, B.D. (2025) Inverse agonism of the FFA4 free fatty acid receptor controls both adipogenesis and mature adipocyte function. Cellular Signalling, 131, (doi: 10.1016/j.cellsig.2025.111714)

Gonzalez-Valdivieso, J., Ciccone, G., Dhawan, U., Quon, T., Barcelona-Estaje, E., Rodrigo-Navarro, A., Castillo, R. R., Milligan, G., Rico, P., Salmeron-Sanchez, M. (2025) NaBC1 boron transporter enables myoblast response to substrate rigidity via fibronectin-binding integrins. Advanced Science,

Zhang, X., Carroll, W., Binh-Anh, T., Nguyen, T.-H., Yang, Z., Ma, M., Huang, X., Hills, A., Guo, H., Karnik, R., Blatt, M. R., Zhang, P. (2025) GORK K+ channel structure and gating vital to informing stomatal engineering. Nature Communications, 16, (doi: 10.1038/s41467-025-57287-7)

McAleese, C., Joudah, G., Salt, I.P., Petrie, J.R., Leiper, J.M., Dowsett, L. B. (2025) Heterogeneous metabolic response of endothelial cells from different vascular beds to experimental hyperglycaemia and metformin. Journal of Physiology, (doi: 10.1113/JP288006)

Ralston, M. R., McCreath, G., Lees, Z. J., Salt, I. P., Sim, M. A.B., Watson, M. J., Freeman, D. J. (2025) Beyond BMI: exploring the role of visceral adipose tissue in intensive care unit outcomes. BJA Open,

Nguyen, T.-H., Krasauskas, J., Nguyen, T. B.-A., Noureen, A., Smedley, M., Christie, J. M., Harwood, W., Blatt, M. R., Hundleby, P. (2025) A promoter collection for cell-targeted analysis within the stomatal complex. Plant Direct, 9, (doi: 10.1002/pld3.70045)

Silva-Alvim, F. A.L., Alvim, J., Hibberd, J. M., Harvey, A. R., Blatt, M. R. (2025) A C4 plant K+ channel accelerates stomata to enhance C3 photosynthesis and water use efficiency. Plant Physiology, (doi: 10.1093/plphys/kiaf039)

Quon, T., Lin, L.-C., Ganguly, A., Hudson, B. D., Tobin, A. B., Milligan, G. (2025) Biased constitutive signaling of the G protein-coupled receptor GPR35 suppresses gut barrier permeability. Journal of Biological Chemistry, 301, (doi: 10.1016/j.jbc.2024.108035)

Hwej, A., Al-Ferjani, A., Alshuweishi, Y., Naji, A., Kennedy, S., Salt, I. (2024) Lack of AMP-activated protein kinase-α1 reduces nitric oxide synthesis in thoracic aorta perivascular adipose tissue. Vascular Pharmacology, 157, (doi: 10.1016/j.vph.2024.107437)

Salt, I. P., Carling, D. (2024) A special issue of Essays in Biochemistry on AMPK and AMPK-related kinases. Essays In Biochemistry, 68, pp. 269-271. (doi: 10.1042/EBC20240038)

Brettell, S. B., Janha, O., Begen, A., Cann, G., Sharma, S., Olaniyan, N., Yelland, T., Hole, A. J., Alam, B., Mayville, E., Gillespie, R., Capper, M., Fidock, D. A., Milligan, G., Clarke, D. J., Tobin, A. B., Jamieson, A. G. (2024) Targeting PfCLK3 with covalent inhibitors: a novel strategy for malaria treatment. Journal of Medicinal Chemistry, (doi: 10.1021/acs.jmedchem.4c01300)

Waghmare, S., Xia, L., Phan Ly, T., Xu, J., Farami, S., Burchmore, R., Blatt, M. R., Karnik, R. (2024) SYNTAXIN OF PLANTS 132 underpins secretion of cargoes associated with salicylic acid signaling and pathogen defense. Plant Physiology, (doi: 10.1093/plphys/kiae541)

Dearlove, E. L., Chatrin, C., Buetow, L., Ahmed, S. F., Schmidt, T., Bushell, M., Smith, B. O., Huang, D. T. (2024) DTX3L ubiquitin ligase ubiquitinates single-stranded nucleic acids. eLife, 13, (doi: 10.7554/elife.98070)

Nguyen, T.-H., Blatt, M. R. (2024) Surrounded by luxury: the necessities of subsidiary cells. Plant, Cell and Environment, 47, pp. 3316-3329. (doi: 10.1111/pce.14872)

Su, J., He, B., Li, P., Yu, B., Cen, Q., Xia, L., Jing, Y., Wu, F., Karnik, R., Xue, D., Blatt, M. R., Wang, Y. (2024) Overexpression of tonoplast Ca2+‐ATPase in guard cells synergistically enhances stomatal opening and drought tolerance. Journal of Integrative Plant Biology, 66, pp. 1587-1602. (doi: 10.1111/jipb.13721)

Baena, G., Xia, L., Waghmare, S., Yu, Z., Guo, Y., Blatt, M. R., Zhang, B., Karnik, R. (2024) Arabidopsis SNARE SYP132 impacts on PIP2;1 trafficking and function in salinity stress. Plant Journal, 118, pp. 1036-1053. (doi: 10.1111/tpj.16649)

Milligan, G. (2024) Editorial for GPR84 Pharmacology. British Journal of Pharmacology, 181, pp. 1497-1499. (doi: 10.1111/bph.16340)

Marsango, S., Milligan, G. (2024) Regulation of the pro-inflammatory G protein-coupled receptor GPR84. British Journal of Pharmacology, 181, pp. 1500-1508. (doi: 10.1111/bph.16098)

Pal, S., Nare, Z., Rao, V. A., Smith, B. O., Morrison, I., Fitzgerald, E. A., Scott, A., Bingham, M. J., Pesnot, T. (2024) Accelerating BRPF1b hit identification with BioPhysical and Active Learning Screening (BioPALS) ChemMedChem, 19, (doi: 10.1002/cmdc.202300590)

Silva-Alvim, F. A.L., Alvim, J. C., Harvey, A., Blatt, M. R. (2024) Speedy stomata of a C4 plant correlate with enhanced K+ channel gating. Plant, Cell and Environment, 47, pp. 817-831. (doi: 10.1111/pce.14775)

Tikhonova, I., Zhang, X., Guseinov, A.-A., Jenkins, L., Li, K., Milligan, G., Zhang, C. (2024) Structural basis for the ligand recognition and signaling of free fatty acid receptors. Science Advances, 10, (doi: 10.1126/sciadv.adj2384)

Blatt, M. R. (2024) A charged existence: a century of transmembrane ion transport in plants. Plant Physiology, (doi: 10.1093/plphys/kiad630)

Barki, N., Jenkins, L., Marsango, S., Dedeo, D., Bolognini, D., Dwomoh, L., Abdelmalik, A. M., Nilsen, M., Stoffels, M., Nagel, F., Schulz, S., Tobin, A. B., Milligan, G. (2023) Phosphorylation bar-coding of free fatty acid receptor 2 is generated in a tissue-specific manner. eLife, 12, (doi: 10.7554/eLife.91861)

Kalita, M., Park, J. H., Kuo, R. C., Hayee, S., Marsango, S., Straniero, V., Alam, I. S., Rivera-Rodriguez, A., Pandrala, M., Carlson, M. L., Reyes, S. T., Jackson, I. M., Suigo, L., Luo, A., Nagy, S. C., Valoti, E., Milligan, G., Habte, F., Shen, B., James, M. L. (2023) PET imaging of innate immune activation using 11C radiotracers targeting GPR84. JACS Au, 3, pp. 3297-3310. (doi: 10.1021/jacsau.3c00435)

Jaffery, H., Huesa, C., Chilaka, S., Cole, J., Doonan, J., Akbar, M., Dunning, L., Tanner, K. E., van 't Hof, R. J., McInnes, I. B., Carmody, R. J., Goodyear, C. S. (2023) IĸB Protein BCL3 as a controller of osteogenesis and bone health. Arthritis and Rheumatology, 75, pp. 2148-2160-2148-2160. (doi: 10.1002/art.42639)

Nguyen, T. B.-A., Lefoulon, C., Nguyen, T.-H., Blatt, M. R., Carroll, W. (2023) Engineering stomata for enhanced carbon capture and water-use efficiency. Trends in Plant Science, 28, pp. 1290-1309. (doi: 10.1016/j.tplants.2023.06.002)

Nguyen, T.-H., Silva-Alvim, F. A. L., Hills, A., Blatt, M. R. (2023) OnGuard3e: a predictive, ecophysiology‐ready tool for gas exchange and photosynthesis research. Plant, Cell and Environment, 46, pp. 3644-3658. (doi: 10.1111/pce.14674)

Irshad, Z., Lund, J., Sillars, A., Løvsletten, N. G., Gharanei, S., Salt, I. P., Freeman, D. J., Gill, J. M.R., Thoresen, G. H., Rustan, A. C., Zammit, V. A. (2023) The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background. FASEB Journal, 37, (doi: 10.1096/fj.202300960RR)

Ganguly, A., Quon, T., Jenkins, L., Joseph, B., Al-awar, R., Chevigne, A., Tobin, A. B., Uehling, D. E., Hoffmann, C., Drube, J., Milligan, G. (2023) G protein-receptor kinases 5/6 are the key regulators of G protein-coupled receptor 35-arrestin interactions. Journal of Biological Chemistry, 299, (doi: 10.1016/j.jbc.2023.105218)

Zhang, X., Wang, Y., Supekar, S., Cao, X., Zhou, J., Dang, J., Chen, S., Jenkins, L., Marsango, S., Li, X., Liu, G., Milligan, G., Feng, M., Fan, H., Gong, W., Zhang, C. (2023) Pro-phagocytic function and structural basis of GPR84 signaling. Nature Communications, 14, (doi: 10.1038/s41467-023-41201-0)

Ciba, M., Dibnah, B., Hudson, B. D., Ulven, E. R. (2023) Development and characterization of potent succinate receptor fluorescent tracers. Journal of Medicinal Chemistry, 66, pp. 8951-8974. (doi: 10.1021/acs.jmedchem.3c00552)

Duncan, E., Vita, L., Dibnah, B., Hudson, B. D. (2023) Metabolite sensing GPCRs controlling interactions between adipose tissue and inflammation. Frontiers in Endocrinology, 14, (doi: 10.3389/fendo.2023.1197102)

Karnik, R., Blatt, M. R. (2023) Analyzing protein–protein interactions using the split-ubiquitin system. Humana Press

Dowsett, L., Duluc, L., Higgins, E., Alghamdi, F., Fast, W., Salt, I. P., Leiper, J. (2023) Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cellular Signalling, 107, (doi: 10.1016/j.cellsig.2023.110676)

Watterson, K., Daly, C., Uwase, C., MacRobbie, C. (2023) The Development of a Novel Educational Resource to Support Student Learning and Engagement in Pharmacology. (doi: 10.1111/bph.16108)

Deni, I. et al. (2023) Mitigating the risk of antimalarial resistance via covalent dual-subunit inhibition of the Plasmodium proteasome. Cell Chemical Biology, 30, pp. 470-485.e6. (doi: 10.1016/j.chembiol.2023.03.002)

Valentini, A., Schultz-Knudsen, K., Højgaard Hansen, A., Tsakoumagkou, A., Jenkins, L., Christensen, H. B., Manandhar, A., Milligan, G., Ulven, T., Rexen Ulven, E. (2023) Discovery of potent tetrazole free fatty acid receptor 2 antagonists. Journal of Medicinal Chemistry, 66, pp. 6105-6121. (doi: 10.1021/acs.jmedchem.2c01935)

Milligan, G. (2023) GPR35: from enigma to therapeutic target. Trends in Pharmacological Sciences, 44, pp. 263-273. (doi: 10.1016/j.tips.2023.03.001)

Javitt, A. et al. (2023) The proteasome regulator PSME4 modulates proteasome activity and antigen diversity to abrogate antitumor immunity in NSCLC. Nature Cancer, 4, pp. 629-647. (doi: 10.1038/s43018-023-00557-4)

Adam, S., Zheng, D., Klein, A., Volz, C., Mullen, W., Shirran, S. L., Smith, B. O., Kalinina, O. V., Müller, R., Koehnke, J. (2023) Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis. Nature Chemistry, 15, pp. 560-568. (doi: 10.1038/s41557-023-01153-w)

Meda Venkata, S. P., Li, H., Xu, L., Koh, J. Y., Nguyen, H., Minjares, M., Li, C., Kowluru, A., Milligan, G., Wang, J.-M. (2023) Inhibition of GPR39 restores defects in endothelial cell–mediated neovascularization under the duress of chronic hyperglycemia: evidence for regulatory roles of the sonic hedgehog signaling axis. Proceedings of the National Academy of Sciences of the United States of America, 120, pp. e2208541120. (doi: 10.1073/pnas.2208541120)

Seale, M., Zhdanov, O., Soons, M. B., Cummins, C., Kroll, E., Blatt, M. R., Zare-Behtash, H., Busse, A., Mastropaolo, E., Bullock, J. M., Viola, I. M., Nakayama, N. (2022) Environmental morphing enables informed dispersal of the dandelion diaspore. eLife, 11, (doi: 10.7554/eLife.81962)

Kowalczyk, D., Nakasone, M. A., Smith, B. O., Huang, D. T. (2022) Bivalent binding of p14ARF to MDM2 RING and acidic domains inhibits E3 ligase function. Life Science Alliance, 5, (doi: 10.26508/lsa.202201472)

Bremner, S. K., Al Shammari, W. O., Milligan, R. S., Hudson, B. D., Sutherland, C., Bryant, N. J., Gould, G. W. (2022) Pleiotropic effects of Syntaxin16 identified by gene editing in cultured adipocytes. Frontiers in Cell and Developmental Biology, 10, (doi: 10.3389/fcell.2022.1033501)

Horaruang, W., Klejchová, M., Carroll, W., Silva-Alvim, F. A.L., Waghmare, S., Papanatsiou, M., Amtmann, A., Hills, A., Alvim, J. C., Blatt, M. R., Zhang, B. (2022) Engineering a K+ channel 'sensory antenna' enhances stomatal kinetics, water use efficiency and photosynthesis. Nature Plants, 8, pp. 1262-1274. (doi: 10.1038/s41477-022-01255-2)

Gracie, J., Zamberlan, F., Andrews, I. B., Smith, B. O., Peveler, W. J. (2022) Growth of plasmonic nanoparticles for aging cask-matured whisky. ACS Applied Nano Materials, 5, pp. 15362-15368. (doi: 10.1021/acsanm.2c03406)

Alharbi, A. G., Tobin, A. B., Milligan, G. (2022) How arrestins and GRKs regulate the function of long chain fatty acid receptors. International Journal of Molecular Sciences, 23, (doi: 10.3390/ijms232012237)

Ryan, S. M., Ruscher, R., Johnston, W. A., Pickering, D. A., Kennedy, M. W., Smith, B. O., Jones, L., Buitrago, G., Field, M. A., Esterman, A. J., McHugh, C. P., Browne, D. J., Cooper, M. M., Ryan, R. Y. M., Doolan, D. L., Engwerda, C. R., Miles, K., Mitreva, M., Croese, J., Rahman, T., Alexandrov, K., Giacomin, P. R., Loukas, A. (2022) Novel antiinflammatory biologics shaped by parasite–host coevolution. Proceedings of the National Academy of Sciences of the United States of America, 119, (doi: 10.1073/pnas.2202795119)

Mahindra, A., Jenkins, L., Marsango, S., Huggett, M., Huggett, M., Robinson, L., Gillespie, J., Rajamanickam, M., Morrison, A., McElroy, S., Tikhonova, I. G., Milligan, G., Jamieson, A. G. (2022) Investigating the structure–activity relationship of 1,2,4-triazine G-protein-coupled receptor 84 (GPR84) antagonists. Journal of Medicinal Chemistry, 65, pp. 11270-11290. (doi: 10.1021/acs.jmedchem.2c00804)

Kjeldsen, A., Kay, J. E., Baxter, S., McColm, S., Serrano-Amatriain, C., Parker, S., Robb, E., Arnold, S. A., Gilmour, C., Raper, A., Robertson, G., Fleming, R., Smith, B. O., Fotheringham, I. G., Christie, J. M., Magneschi, L. (2022) The fluorescent protein iLOV as a reporter for screening of high‐yield production of antimicrobial peptides in Pichia pastoris. Microbial Biotechnology, 15, pp. 2126-2139. (doi: 10.1111/1751-7915.14034)

Marsango, S., Barki, N., Jenkins, L., Tobin, A. B., Milligan, G. (2022) Therapeutic validation of an orphan G protein-coupled receptor: the case of GPR84. British Journal of Pharmacology, 179, pp. 3529-3541. (doi: 10.1111/bph.15248)

Marsango, S., Jenkins, L., Pediani, J. D., Bradley, S. J., Ward, R. J., Hesse, S., Biener, G., Stoneman, M. R., Tobin, A. B., Raicu, V., Milligan, G. (2022) The M1 muscarinic receptor is present in situ as a ligand-regulated mixture of monomers and oligomeric complexes. Proceedings of the National Academy of Sciences of the United States of America, 119, (doi: 10.1073/pnas.2201103119)

Caspar, B., Cocchiara, P., Melet, A., Van Emelen, K., Van der Aa, A., Milligan, G., Herbeuval, J.-P. (2022) CXCR4 as a novel target in immunology: moving away from typical antagonists. Future Drug Discovery, 4, (doi: 10.4155/fdd-2022-0007)

Torres Cabán, C. C., Yang, M., Lai, C., Yang, L., Subach, F. V., Smith, B. O., Piatkevich, K. D., Boyden, E. S. (2022) Tuning the sensitivity of genetically encoded fluorescent potassium indicators through structure-guided and genome mining strategies. ACS Sensors, 7, pp. 1336-1346. (doi: 10.1021/acssensors.1c02201)

Marsango, S., Ward, R. J., Jenkins, L., Butcher, A. J., Al Mahmud, Z., Dwomoh, L., Nagel, F., Schulz, S., Tikhonova, I. G., Tobin, A. B., Milligan, G. (2022) Selective phosphorylation of threonine residues defines GPR84-arrestin interactions of biased ligands. Journal of Biological Chemistry, 298, (doi: 10.1016/j.jbc.2022.101932)

Thu, N. B.A., Amtmann, A., Blatt, M. R., Nguyen, T.-H. (2022) Stomata under salt stress—what can mechanistic modeling tell us? Academic Press

Živković, D., Sanchez Dafun, A., Menneteau, T., Schahl, A., Lise, S., Kervarrec, C., Toste Rêgo, A., da Fonseca, P. C. A., Chavent, M., Pineau, C., Burlet-Schiltz, O., Marcoux, J., Bousquet, M.-P. (2022) Proteasome complexes experience profound structural and functional rearrangements throughout mammalian spermatogenesis. Proceedings of the National Academy of Sciences of the United States of America, 119, pp. e2116826119. (doi: 10.1073/pnas.2116826119)

Tibbo, A. J., Mika, D., Dobi, S., Ling, J., McFall, A., Tejeda, G. S., Blair, C., MacLeod, R., MacQuaide, N., Gök, C., Fuller, W., Smith, B. O., Smith, G. L., Vandecasteele, G., Brand, T., Baillie, G. S. (2022) Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins. Journal of Molecular and Cellular Cardiology, 165, pp. 86-102. (doi: 10.1016/j.yjmcc.2022.01.001)

Barki, N., Bolognini, D., Börjesson, U., Jenkins, L., Riddell, J., Hughes, D. I., Ulven, T., Hudson, B. D., Rexen Ulven, E., Dekker, N., Tobin, A. B., Milligan, G. (2022) Chemogenetics defines the roles of short chain fatty acid receptors within the gut-brain axis. eLife, 11, (doi: 10.7554/eLife.73777)

Divorty, N., Jenkins, L., Ganguly, A., Butcher, A. J., Hudson, B. D., Schulz, S., Tobin, A. B., Nicklin, S. A., Milligan, G. (2022) Agonist-induced phosphorylation of orthologues of the orphan receptor GPR35 functions as an activation sensor. Journal of Biological Chemistry, 298, (doi: 10.1016/j.jbc.2022.101655)

Blatt, M. R., Jezek, M., Lew, V. L., Hills, A. (2022) What can mechanistic models tell us about guard cells, photosynthesis, and water use efficiency? Trends in Plant Science, 27, pp. 166-179. (doi: 10.1016/j.tplants.2021.08.010)

Nakasone, M. A., Majorek, K. A., Gabrielsen, M., Sibbet, G. J., Smith, B. O., Huang, D. T. (2022) Structure of UBE2K-Ub/E3/polyUb reveals mechanisms of K48-linked Ub chain extension. Nature Chemical Biology, 18, pp. 422-431. (doi: 10.1038/s41589-021-00952-x)

Neckebroeck, A., Kelly, S. M., Smith, B. O., Clark, J. S. (2022) Synthesis of the prototypical cyclopropyl dipeptide mimic and evaluation of its turn-inducing capability. Journal of Organic Chemistry, 87, pp. 258-270. (doi: 10.1021/acs.joc.1c02344)

Zhdanov, O., Blatt, M. R., Zare-Behtash, H., Busse, A. (2022) Unidirectional versus bidirectional brushing: simulating wind influence on Arabidopsis thaliana. Quantitative Plant Biology, 3, (doi: 10.1017/qpb.2021.14)

Scarpa, M., Molloy, C., Jenkins, L., Strellis, B., Budgett, R. F., Hesse, S., Dwomoh, L., Marsango, S., Tejeda, G. S., Rossi, M., Ahmed, Z., Milligan, G., Hudson, B. D., Tobin, A. B., Bradley, S. J. (2021) Biased M1 muscarinic receptor mutant mice show accelerated progression of prion neurodegenerative disease. Proceedings of the National Academy of Sciences of the United States of America, 118, pp. e2107389118. (doi: 10.1073/pnas.2107389118)

Lin, L.-C., Quon, T., Engberg, S., Mackenzie, A. E., Tobin, A. B., Milligan, G. (2021) G protein-coupled receptor GPR35 suppresses lipid accumulation in hepatocytes. ACS Pharmacology and Translational Science, 4, pp. 1835-1848. (doi: 10.1021/acsptsci.1c00224)

Blatt, M. (2021) Ae fond fareweel. Plant Physiology, 187, pp. 2341-2343. (doi: 10.1093/plphys/kiab467)

Kok, F. O., Wang, H., Riedlova, P., Goodyear, C. S., Carmody, R. J. (2021) Defining the structure of the NF-ĸB pathway in human immune cells using quantitative proteomic data. Cellular Signalling, 88, (doi: 10.1016/j.cellsig.2021.110154)

Brown, A. J.H. et al. (2021) From structure to clinic: design of a muscarinic M1 receptor agonist with potential to treatment of Alzheimer’s disease. Cell, 184, pp. 5886-5901.e22. (doi: 10.1016/j.cell.2021.11.001)

Mahindra, A., Tejeda, G., Rossi, M., Janha, O., Herbert, I., Morris, C., Morgan, D. C., Beattie, W., Montezano, A. C., Hudson, B., Tobin, A. B., Bhella, D., Touyz, R. M., Jamieson, A. G., Baillie, G. S., Blair, C. M. (2021) Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction. PLoS ONE, 16, (doi: 10.1371/journal.pone.0260283)

Somma, D., Kok, F. O., Kerrigan, D., Wells, C. A., Carmody, R. J. (2021) Defining the role of nuclear factor NF-κB p105 subunit in human macrophage by transcriptomic analysis of NFKB1 knockout THP-1 cells. Frontiers in Immunology, 12, (doi: 10.3389/fimmu.2021.669906)

Milligan, G., Jenkins, L., Marsango, S., Mancini, S., Mahmud, Z. A., Morrison, A., McElroy, S., Bennett, K., Barnes, M., Tobin, A., Tikhonova, I. (2021) Discovery and characterization of novel antagonists of the proinflammatory orphan receptor GPR84. ACS Pharmacology and Translational Science, 4, pp. 1598-1613. (doi: 10.1021/acsptsci.1c00151)

Prabhakar, A. T., James, C. D., Das, D., Otoa, R., Day, M., Burgner, J., Fontan, C. T., Wang, X., Wieland, A., Donaldson, M. M., Bristol, M. L., Li, R., Oliver, A. W., Pearl, L. H., Smith, B. O., Glass, S., Morgan, I. M. (2021) CK2 phosphorylation of human papillomavirus 16 E2 on serine 23 promotes interaction with TopBP1 and is critical for E2 interaction with mitotic chromatin and the viral life cycle. mBio, 12, (doi: 10.1128/mbio.01163-21)

Buist, H. K., Luchowska-Stańska, U., van Basten, B., Valli, J., Smith, B. O., Baillie, G. S., Rickman, C., Ricketts, B., Davidson, A., Hannam, R., Sunderland, J., Yarwood, S. J. (2021) Identification and characterization of an affimer affinity reagent for the detection of the cAMP sensor, EPAC1. Cells, 10, (doi: 10.3390/cells10092307)

Ahwazi, D., Neopane, K., Markby, G. R., Kopietz, F., Ovens, A. J., Dall, M., Hassing, A. S., Graesle, P., Alshuweishi, Y. A. I., Treebak, J. T., Salt, I., Göransson, O., Zeqiraj, E., Scott, J. W., Sakamoto, K. (2021) Investigation of the specificity and mechanism of action of the ULK1/AMPK inhibitor SBI-0206965. Biochemical Journal, 478, pp. 2977-2997. (doi: 10.1042/BCJ20210284)

Palmer, T. M., Salt, I. P. (2021) Nutrient regulation of inflammatory signalling in obesity and vascular disease. Clinical Science, 135, pp. 1563-1590. (doi: 10.1042/CS20190768)

Morgan, D. C., Morris, C., Mahindra, A., Blair, C. M., Tejeda, G., Herbert, I., Turnbull, M. L., Lieber, G., Willett, B. J., Logan, N., Smith, B., Tobin, A. B., Bhella, D., Baillie, G. S., Jamieson, A. G. (2021) Stapled ACE2 peptidomimetics designed to target the SARS-CoV-2 spike protein do not prevent virus internalisation. Peptide Science, 113, (doi: 10.1002/pep2.24217)

Jezek, M., Silva-Alvim, F. A.L., Hills, A., Donald, N., Ishka, M. R., Shadbolt, J., He, B., Lawson, T., Harper, J. F., Wang, Y., Lew, V. L., Blatt, M. R. (2021) Guard cell endomembrane Ca2+-ATPases underpin a ‘carbon memory’ of photosynthetic assimilation that impacts on water-use efficiency. Nature Plants, 7, pp. 1301-1313. (doi: 10.1038/s41477-021-00966-2)

Boleij, A., Fathi, P., Dalton, W., Park, B., Wu, X., Huso, D., Allen, J., Besharati, S., Anders, R. A., Housseau, F., Mackenzie, A. E., Jenkins, L., Milligan, G., Wu, S., Sears, C. L. (2021) G-protein coupled receptor 35 (GPR35) regulates the colonic epithelial cell response to enterotoxigenic Bacteroides fragilis. Communications Biology, 4, (doi: 10.1038/s42003-021-02014-3)

Salt, I. P., Nunes, J. R.C., Fullerton, M. D. (2021) Metformin again? Atheroprotection mediated by macrophage AMPK and ATF1. Cardiovascular Research, 117, pp. 1233-1234. (doi: 10.1093/cvr/cvab065)

Morris, E. P., da Fonseca, P. C.A. (2021) How to build a proteasome. Nature Structural and Molecular Biology, 28, pp. 409-410. (doi: 10.1038/s41594-021-00592-8)

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Bolognini, D., Dedeo, D., Milligan, G. (2021) Metabolic and inflammatory functions of short-chain fatty acid receptors. Current Opinion in Endocrine and Metabolic Research, 16, pp. 1-9. (doi: 10.1016/j.coemr.2020.06.005)

Knuhtsen, A., Whiting, R., McWhinnie, F. S., Whitmore, C., Smith, B. O., Green, A. C., Timperley, C. M., Kinnear, K. I., Jamieson, A. G. (2021) μ-conotoxin KIIIA peptidomimetics that block human voltage-gated sodium channels. Peptide Science, 113, (doi: 10.1002/pep2.24203)

Ward, R. J., Pediani, J. D., Marsango, S., Jolly, R., Stoneman, M. R., Biener, G., Handel, T. M., Raicu, V., Milligan, G. (2021) Chemokine receptor CXCR4 oligomerization is disrupted selectively by the antagonist ligand IT1t. Journal of Biological Chemistry, 296, (doi: 10.1074/jbc.RA120.016612)

Zhdanov, O., Blatt, M. R., Cammarano, A., Zare-Behtash, H., Busse, A. (2020) A new perspective on mechanical characterisation of Arabidopsis stems through vibration tests. Journal of the Mechanical Behavior of Biomedical Materials, 112, (doi: 10.1016/j.jmbbm.2020.104041)

Alghamdi, F., Alshuweishi, Y., Salt, I. P. (2020) Regulation of nutrient uptake by AMP-activated protein kinase. Cellular Signalling, 76, (doi: 10.1016/j.cellsig.2020.109807)

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Smith, E. L., Somma, D., Kerrigan, D., McIntyre, Z., Cole, J. J., Liang, K. L., Kiely, P. A., Keeshan, K., Carmody, R. J. (2019) The regulation of sequence specific NF-ĸB DNA binding and transcription by IKKβ Phosphorylation of NF-ĸB p50 at Serine 80. Nucleic Acids Research, 47, pp. 11151-11161. (doi: 10.1093/nar/gkz873)

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Katwan, O. J., Alghamdi, F., Almabrouk, T. A., Mancini, S. J., Kennedy, S., Oakhill, J. S., Scott, J. W., Salt, I. P. (2019) AMP-activated protein kinase complexes containing the β2 regulatory subunit are upregulated during and contribute to adipogenesis. Biochemical Journal, 476, pp. 1725-1740. (doi: 10.1042/BCJ20180714)

Blackman, M. J., Stokes, B. H., Yoo, E., Murithi, J. M., Luth, M. R., Afanasyev, P., da Fonseca, P. C.A., Winzeler, E. A., Ng, C. L., Bogyo, M., Fidock, D. A. (2019) Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents. PLoS Pathogens, 15, (doi: 10.1371/journal.ppat.1007722)

Stoneman, M. R., Biener, G., Ward, R. J., Pediani, J. D., Badu, D., Eis, A., Popa, I., Milligan, G., Raicu, V. (2019) A general method to quantify ligand-driven oligomerization from fluorescence-based images. Nature Methods, 16, pp. 493-496. (doi: 10.1038/s41592-019-0408-9)

Bolognini, D., Barki, N., Butcher, A. J., Hudson, B. D., Sergeev, E., Molloy, C., Moss, C. E., Bradley, S. J., Le Gouill, C., Bouvier, M., Tobin, A. B., Milligan, G. (2019) Chemogenetics defines receptor-mediated functions of short chain free fatty acids. Nature Chemical Biology, 15, pp. 489-498. (doi: 10.1038/s41589-019-0270-1)

Zhang, B., Karnik, R., Alvim, J., Donald, N., Blatt, M. R. (2019) Dual sites for SEC11 on the SNARE SYP121 implicate a binding exchange during secretory traffic. Plant Physiology, 180, pp. 228-239. (doi: 10.1104/pp.18.01315)

Milligan, G., Ward, R. J., Marsango, S. (2019) GPCR homo-oligomerization. Current Opinion in Cell Biology, 57, pp. 40-47. (doi: 10.1016/j.ceb.2018.10.007)

Mackenzie, A. E., Quon, T., Lin, L.-C., Hauser, A. S., Jenkins, L., Inoue, A., Tobin, A. B., Gloriam, D. E., Hudson, B. D., Milligan, G. (2019) Receptor selectivity between the G proteins Gα12 and Gα13 is defined by a single leucine-to-isoleucine variation. FASEB Journal, 33, pp. 5005-5017. (doi: 10.1096/fj.201801956R)

Papanatsiou, M., Petersen, J., Henderson, L., Wang, Y., Christie, J.M., Blatt, M.R. (2019) Optogenetic manipulation of stomatal kinetics improves carbon assimilation, water use, and growth. Science, 363, pp. 1456-1459. (doi: 10.1126/science.aaw0046)

Zhao, C. et al. (2019) Evolution of chloroplast retrograde signaling facilitates green plant adaptation to land. Proceedings of the National Academy of Sciences of the United States of America, 116, pp. 5015-5020. (doi: 10.1073/pnas.1812092116)

Knuhtsen, A., Whitmore, C., McWhinnie, F. S., McDougall, L., Whiting, R., Smith, B. O., Timperley, C. M., Green, A. C., Kinnear, K. I., Jamieson, A. G. (2019) α-conotoxin GI triazole-peptidomimetics: potent and stable blockers of a human acetylcholine receptor. Chemical Science, 10, pp. 1671-1676. (doi: 10.1039/C8SC04198A)

Mancini, S., Mahmud, Z. A., Jenkins, L., Bolognini, D., Newman, R., Barnes, M., Edye, M. E., McMahon, S. B., Tobin, A. B., Milligan, G. (2019) On-target and off-target effects of novel orthosteric and allosteric activators of GPR84. Scientific Reports, 9, (doi: 10.1038/s41598-019-38539-1)

Liao, X., Zhang, B., Blatt, M. R., Jenkins, G. I. (2019) A FRET method for investigating dimer/monomer status and conformation of the UVR8 photoreceptor. Photochemical and Photobiological Sciences, 18, pp. 367-374. (doi: 10.1039/C8PP00489G)

Müskens, F. M., Ward, R. J., Herkt, D., van de Langemheen, H., Tobin, A. B., Liskamp, R. M.J., Milligan, G. (2019) Design, synthesis and evaluation of a diazirine photoaffinity probe for ligand-based receptor capture targeting G protein-coupled receptors. Molecular Pharmacology, 95, pp. 196-209. (doi: 10.1124/mol.118.114249)

Petrie, J. R., Salt, I. P. (2019) Diabetes and vascular disease. Springer

Rezig, I. M., Bremner, S. K., Bhutta, M. S., Salt, I. P., Gould, G. W., McInerny, C. J. (2019) Genetic and cytological methods to study ESCRT cell cycle function in fission yeast. Humana Press

Strembitska, A., Mancini, S. J., Gamwell, J. M., Palmer, T. M., Baillie, G. S., Salt, I. P. (2018) A769662 inhibits insulin-stimulated Akt activation in human macrovascular endothelial cells independent of AMP-activated protein kinase. International Journal of Molecular Sciences, 19, (doi: 10.3390/ijms19123886)

Waghmare, S., Lileikyte, E., Karnik, R., Goodman, J. K., Blatt, M. R., Jones, A. M.E. (2018) SNAREs SYP121 and SYP122 mediate the secretion of distinct cargo subsets. Plant Physiology, 178, pp. 1679-1688. (doi: 10.1104/pp.18.00832)

Kennedy, A. J., Ballante, F., Johansson, J. R., Milligan, G., Sunström, L., Nordqvist, A., Carlsson, J. (2018) Structural characterization of agonist binding to protease-activated receptor 2 through mutagenesis and computational modeling. ACS Pharmacology and Translational Science, 1, pp. 119-133. (doi: 10.1021/acsptsci.8b00019)

Hansen, A. H., Sergeev, E., Bolognini, D., Sprenger, R. R., Ekberg, J. H., Ejsing, C. S., McKenzie, C. J., Rexen Ulven, E., Milligan, G., Ulven, T. (2018) Discovery of a potent thiazolidine free fatty acid receptor 2 agonist with favorable pharmacokinetic properties. Journal of Medicinal Chemistry, 61, pp. 9534-9550. (doi: 10.1021/acs.jmedchem.8b00855)

Lefoulon, C., Waghmare, S., Karnik, R., Blatt, M. R. (2018) Gating control and K+ uptake by the KAT1 K+ channel leaveraged through membrane anchoring of the trafficking protein SYP121. Plant, Cell and Environment, 41, pp. 2668-2677. (doi: 10.1111/pce.13392)

Drew, J. E., Reichardt, N., Williams, L. M., Mayer, C.-D., Walker, A. W., Farquharson, A. J., Kastora, S., Farquharson, F., Milligan, G., Morrison, D. J., Preston, T., Flint, H. J., Louis, P. (2018) Dietary fibers inhibit obesity in mice, but host responses in the cecum and liver appear unrelated to fiber-specific changes in cecal taxonomic composition. Scientific Reports, 8, (doi: 10.1038/s41598-018-34081-8)

Zhang, B., Karnik, R., Donald, N., Blatt, M. R. (2018) A GPI signal peptide-anchored split-ubiquitin (GPS) system for detecting soluble bait protein interactions at the membrane. Plant Physiology, 178, pp. 13-17. (doi: 10.1104/pp.18.00577)

Divorty, N., Milligan, G., Graham, D., Nicklin, S. A. (2018) The orphan receptor GPR35 contributes to angiotensin II–induced hypertension and cardiac dysfunction in mice. American Journal of Hypertension, 31, pp. 1049-1058. (doi: 10.1093/ajh/hpy073)

Feroz, H., Ferlez, B., Lefoulon, C., Ren, T., Baker, C. S., Gajewski, J. P., Lugar, D. J., Gaudana, S. B., Butler, P. J., Hühn, J., Lamping, M., Parak, W. J., Hibberd, J. M., Kerfeld, C. A., Smirnoff, N., Blatt, M. R., Golbeck, J. H., Kumar, M. (2018) Light-driven chloride transport kinetics of halorhodopsin. Biophysical Journal, 115, pp. 353-360. (doi: 10.1016/j.bpj.2018.06.009)

Marsango, S., Ward, R. J., Alvarez-Curto, E., Milligan, G. (2018) Muscarinic receptor oligomerization. Neuropharmacology, 136, pp. 401-410. (doi: 10.1016/j.neuropharm.2017.11.023)

Binti Mohd Amir, N. A.S., Mackenzie, A. E., Jenkins, L., Boustani, K., Hillier, M. C., Tsuchiya, T., Milligan, G., Pease, J. E. (2018) Evidence for the existence of a CXCL17 receptor distinct from GPR35. Journal of Immunology, 201, pp. 714-724. (doi: 10.4049/jimmunol.1700884)

Milligan, G. (2018) G protein-coupled receptors not currently in the spotlight: free fatty acid receptor 2 and GPR35. British Journal of Pharmacology, 175, pp. 2543-2553. (doi: 10.1111/bph.14042)

Zhdanov, O., Busse, A., Blatt, M., Zare-Behtash, H. (2018) A specialised wind tunnel for investigation of ecophysiological response of plants to wind.

Butcher, S. K., O'Carroll, C. E., Wells, C. A., Carmody, R. J. (2018) Toll-like receptors drive specific patterns of tolerance and training on restimulation of macrophages. Frontiers in Immunology, 9, (doi: 10.3389/fimmu.2018.00933)

Salomé, M., Magee, A., Yalla, K., Chaudhury, S., Sarrou, E., Carmody, R. J., Keeshan, K. (2018) A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling. Cell Death and Disease, 9, (doi: 10.1038/s41419-018-0467-3)

Milligan, G., Inoue, A. (2018) Genome editing provides new insights into receptor-controlled signalling pathways. Trends in Pharmacological Sciences, 39, pp. 481-493. (doi: 10.1016/j.tips.2018.02.005)

Blatt, M. R. (2018) Concepts and techniques in plant membrane physiology. John Wiley & Sons, Ltd

Blatt, M.R., Thiel, G. (2018) SNARE components and mechanisms of exocytosis in plants. John Wiley & Sons, Ltd

Mancini, S. J., Boyd, D., Katwan, O. J., Strembitska, A., Almabrouk, T. A., Kennedy, S., Palmer, T. M., Salt, I. P. (2018) Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms. Scientific Reports, 8, (doi: 10.1038/s41598-018-23420-4)

Almabrouk, T. A.M., White, A. D., Ugusman, A. B., Skiba, D. S., Katwan, O. J., Alganga, H., Guzik, T. J., Touyz, R. M., Salt, I. P., Kennedy, S. (2018) High fat diet attenuates the anticontractile activity of aortic PVAT via a mechanism involving AMPK and reduced adiponectin secretion. Frontiers in Physiology, 9, (doi: 10.3389/fphys.2018.00051)

Speirs, C., Williams, J. J.L., Riches, K., Salt, I. P., Palmer, T. M. (2018) Linking energy sensing to suppression of JAK-STAT signalling: a potential route for repurposing AMPK activators? Pharmacological Research, 128, pp. 88-100. (doi: 10.1016/j.phrs.2017.10.001)

Pediani, J. D., Ward, R. J., Marsango, S., Milligan, G. (2018) Spatial intensity distribution analysis: studies of G Protein-coupled receptor oligomerization. Trends in Pharmacological Sciences, 39, pp. 175-186. (doi: 10.1016/j.tips.2017.09.001)

Pantin, F., Blatt, M. R. (2018) Stomatal response to humidity: blurring the boundary between active and passive movement. Plant Physiology, 176, pp. 485-488. (doi: 10.1104/pp.17.01699)

Mancini, S. J., Salt, I. P. (2018) Investigating the role of AMPK in inflammation. Humana Press

Mitchell, J. P., Carmody, R. J. (2018) NF-κB and the Transcriptional Control of Inflammation. Elsevier

Reichardt, N., Vollmer, M., Holtrop, G., Farquharson, F. M., Wefers, D., Bunzel, M., Duncan, S. H., Drew, J. E., Williams, L. M., Milligan, G., Preston, T., Morrison, D., Flint, H. J., Louis, P. (2018) Specific substrate-driven changes in human faecal microbiota composition contrast with functional redundancy in short-chain fatty acid production. ISME Journal, 12, pp. 610-622. (doi: 10.1038/ismej.2017.196)

Mahmud, Z. A., Jenkins, L., Ulven, T., Labéguère, F., Gosmini, R., De Vos, S., Hudson, B. D., Tikhonova, I. G., Milligan, G. (2017) Three classes of ligands each bind to distinct sites on the orphan G protein-coupled receptor GPR84. Scientific Reports, 7, (doi: 10.1038/s41598-017-18159-3)

Viskaitis, P., Irvine, E. E., Smith, M. A., Choudhury, A. I., Alvarez-Curto, E., Glegola, J. A., Hardy, D. G., Pedroni, S. M.A., Paiva Pessoa, M. R., Fernando, A. B.P., Katsouri, L., Sardini, A., Ungless, M. A., Milligan, G., Withters, D. J. (2017) Modulation of SF1 neuron activity coordinately regulates both feeding behaviour and associated emotional states. Cell Reports, 21, pp. 3559-3572. (doi: 10.1016/j.celrep.2017.11.089)

Cooper, A., Vance, S. J., Smith, B. O., Kennedy, M. W. (2017) Frog foams and natural protein surfactants. Colloids and Surfaces A: Physicochemical and Engineering Aspects, 534, pp. 120-129. (doi: 10.1016/j.colsurfa.2017.01.049)

Wang, Y., Hills, A., Vialet-Chabrand, S., Papanatsiou, M., Griffiths, H., Rogers, S., Lawson, T., Lew, V. L., Blatt, M. R. (2017) Unexpected connections between humidity and ion transport discovered using a model to bridge guard cell-to-leaf scales. Plant Cell, 29, pp. 2921-2939. (doi: 10.1105/tpc.17.00694)

Sergeev, E., Hansen, A. H., Bolognini, D., Kawakami, K., Kishi, T., Aoki, J., Ulven, T., Inoue, A., Hudson, B. D., Milligan, G. (2017) A single extracellular amino acid in Free Fatty Acid Receptor 2 defines antagonist species selectivity and G protein selection bias. Scientific Reports, 7, (doi: 10.1038/s41598-017-14096-3)

Gabrielsen, M., Buetow, L., Nakasone, M. A., Ahmed, S. F., Sibbet, G. J., Smith, B. O., Zhang, W., Sidhu, S. S., Huang, D. T. (2017) A general strategy for discovery of inhibitors and activators of RING and U-box E3 ligases with ubiquitin variants. Molecular Cell, 68, pp. 456-470.e10. (doi: 10.1016/j.molcel.2017.09.027)

Larson, E. R., Van Zelm, E., Roux, C., Marion-Poll, A., Blatt, M. R. (2017) Clathrin Heavy Chain subunits coordinate endo- and exocytic traffic and affect stomatal movement. Plant Physiology, 175, pp. 708-720. (doi: 10.1104/pp.17.00970)

Almabrouk, T. A. M., Ugusman, A. B., Katwan, O. J., Salt, I. P., Kennedy, S. (2017) Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adiponectin release. British Journal of Pharmacology, 174, pp. 3398-3410. (doi: 10.1111/bph.13633)

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Magennis, S., Toulmin, A., Baltierra-Jasso, L. E., Morten, M. J., Sabir, T., McGlynn, P., Schröder, G. F., Smith, B. O., Magennis, S. W. (2017) Conformational heterogeneity in a fully-complementary DNA three-way junction with a GC-rich branchpoint. Biochemistry, 56, pp. 4985-4991. (doi: 10.1021/acs.biochem.7b00677)

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Ward, R. J., Marsango, S., Pediani, J. D., Milligan, G. (2017) The use of spatial intensity distribution analysis to examine G protein-coupled receptor oligomerization. Humana Press

Prokop, S., Perry, N. A., Vishnivetskiy, S. A., Toth, A. D., Inoue, A., Milligan, G., Iverson, T. M., Hunyady, L., Gurevich, V. V. (2017) Differential manipulation of arrestin-3 binding to basal and agonist-activated G protein-coupled receptors. Cellular Signalling, 36, pp. 98-107. (doi: 10.1016/j.cellsig.2017.04.021)

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Lopez-Gimenez, J., Alvarez-Curto, E., Milligan, G. (2017) M3 muscarinic acetylcholine receptor facilitates the endocytosis of mu opioid receptor mediated by morphine independently of the formation of heteromeric complexes. Cellular Signalling, 35, pp. 208-222. (doi: 10.1016/j.cellsig.2017.04.006)

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Kaspersen, M. H., Jenkins, L., Dunlop, J., Milligan, G., Ulven, T. (2017) Succinct synthesis of saturated hydroxy fatty acids and in vitro evaluation of all hydroxylauric acids on FFA1, FFA4 and GPR84. MedChemComm, 8, pp. 1360-1365. (doi: 10.1039/c7md00130d)

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Marsango, S., Caltabiano, G., Jiménez-Rosés, M., Millan, M. J., Pediani, J. D., Ward, R. J., Milligan, G. (2017) A molecular basis for selective antagonist destabilization of dopamine D3 receptor quaternary organization. Scientific Reports, 7, (doi: 10.1038/s41598-017-02249-3)

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Mackenzie, A. E., Milligan, G. (2017) The emerging pharmacology and function of GPR35 in the nervous system. Neuropharmacology, 113, pp. 661-671. (doi: 10.1016/j.neuropharm.2015.07.035)

Mancini, S. J., White, A. D., Bijland, S., Rutherford, C., Graham, D., Richter, E. A., Viollet, B., Touyz, R. M., Palmer, T. M., Salt, I. P. (2017) Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptorassociated kinase-4 phosphorylation. Molecular and Cellular Endocrinology, 440, pp. 44-56. (doi: 10.1016/j.mce.2016.11.010)

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Hansen, A. H., Sergeev, E., Pandey, S. K., Hudson, B. D., Christiansen, E., Milligan, G., Ulven, T. (2017) Development and characterization of a fluorescent tracer for the free fatty acid receptor 2 (FFA2/GPR43) Journal of Medicinal Chemistry, 60, pp. 5638-5645. (doi: 10.1021/acs.jmedchem.7b00338)

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Alvarez-Curto, E., Inoue, A., Jenkins, L., Raihan, S. Z., Prihandoko, R., Tobin, A. B., Milligan, G. (2016) Targeted elimination of G proteins and arrestins defines their specific contributions to both intensity and duration of G protein-coupled receptor signalling. Journal of Biological Chemistry, 291, pp. 27147-27159. (doi: 10.1074/jbc.M116.754887)

Docherty, C. K., Salt, I. P., Mercer, J. R. (2016) Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells. Stem Cell Research and Therapy, 7, (doi: 10.1186/s13287-016-0323-2)

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Hudson, B. D. (2016) Using biosensors to study free fatty acid receptor pharmacology and function. Springer

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Liang, K. L., Paredes, R., Carmody, R., Eyers, P. A., Meyer, S., McCarthy, T. V., Keeshan, K. (2016) Human TRIB2 oscillates during the cell cycle and promotes ubiquitination and degradation of CDC25C. International Journal of Molecular Sciences, 17, (doi: 10.3390/ijms17091378)

Morris, R. J., Brandani, G. B., Desai, V., Smith, B. O., Schor, M., MacPhee, C. E. (2016) The conformation of interfacially adsorbed Ranaspumin-2 Is an arrested state on the unfolding pathway. Biophysical Journal, 111, pp. 732-742. (doi: 10.1016/j.bpj.2016.06.006)

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Dean, A., Nilsen, M., Loughlin, L., Salt, I. P., MacLean, M. R. (2016) Metformin reverses development of pulmonary hypertension via aromatase inhibition. Hypertension, 68, pp. 446-454. (doi: 10.1161/HYPERTENSIONAHA.116.07353)

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Pediani, J. D., Ward, R. J., Godin, A. G., Marsango, S., Milligan, G. (2016) Dynamic regulation of quaternary organization of the M1 muscarinic receptor by subtype-selective antagonist drugs. Journal of Biological Chemistry, 291, pp. 13132-13146. (doi: 10.1074/jbc.M115.712562)

Ashraf, K. U., Josts, I., Mosbahi, K., Kelly, S. M., Byron, O., Smith, B. O., Walker, D. (2016) The potassium binding protein Kbp is a cytoplasmic potassium sensor. Structure, 24, pp. 741-749. (doi: 10.1016/j.str.2016.03.017)

Nuber, S., Zabel, U., Lorenz, K., Nuber, A., Milligan, G., Tobin, A. B., Lohse, M. J., Hoffmann, C. (2016) β-Arrestin biosensors reveal a rapid, receptor-dependent activation/deactivation cycle. Nature, 531, pp. 661-664. (doi: 10.1038/nature17198)

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Grundmann, M., Tikhonova, I. G., Hudson, B. D., Smith, N. J., Mohr, K., Ulven, T., Milligan, G., Kenakin, T., Kostenis, E. (2016) A molecular mechanism for sequential activation of a G Protein-coupled receptor. Cell Chemical Biology, 23, pp. 392-403. (doi: 10.1016/j.chembiol.2016.02.014)

Pratt, A. G., Anderson, A. E., Carmody, R. J., Isaacs, J. D. (2016) B cell lymphoma 3 (Bcl-3) in CD4+ T cell mediated RA pathogenesis: Comment on the article by Meguro et al. Arthritis and Rheumatology, 68, pp. 770-771. (doi: 10.1002/art.39509)

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Li, H., O’Donoghue, A. J., van der Linden, W. A., Xie, S. C., Yoo, E., Foe, I. T., Tilley, L., Craik, C. S., da Fonseca, P. C.A., Bogyo, M. (2016) Structure- and function-based design of Plasmodium-selective proteasome inhibitors. Nature, 530, pp. 233-236. (doi: 10.1038/nature16936)

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Sergeev, E., Hansen, A. H., Pandey, S. K., MacKenzie, A. E., Hudson, B. D., Ulven, T., Milligan, G. (2016) Non-equivalence of key positively charged residues of the free fatty acid 2 receptor in the recognition and function of agonist versus antagonist ligands. Journal of Biological Chemistry, 291, pp. 303-317. (doi: 10.1074/jbc.M115.687939)

Christiansen, E., Hudson, B. D., Hansen, A. H., Milligan, G., Ulven, T. (2016) Development and characterization of a potent free fatty acid receptor 1 (FFA1) fluorescent tracer. Journal of Medicinal Chemistry, 59, pp. 4849-4858. (doi: 10.1021/acs.jmedchem.6b00202)

Prihandoko, R., Alvarez-Curto, E., Hudson, B. D., Butcher, A. J., Ulven, T., Miller, A. M., Tobin, A. B., Milligan, G. (2016) Distinct phosphorylation clusters determines the signalling outcome of the free fatty acid receptor FFA4/GPR120. Molecular Pharmacology, 89, pp. 505-520. (doi: 10.1124/mol.115.101949)

McCallum, J. E., Mackenzie, A. E., Divorty, N., Clarke, C., Delles, C., Milligan, G., Nicklin, S. A. (2016) G protein-coupled receptor 35 mediates human saphenous vein vascular smooth muscle cell migration and endothelial cell proliferation. Journal of Vascular Research, 52, pp. 383-395. (doi: 10.1159/000444754)