School of Molecular Biosciences

T‌he MVLS Integrated Protein Analysis Facility focuses on macromolecular structure and function characterisations. We offer a wide range of biophysical techniques and expertise to both internal and external users. We also offer training of students and staff who wants to run their own experiments. We keep updating our equipment, and have now installed the second Biacome 1K+ in the UK, which is available to users. 

Recently we have started offering protein expression and purificaion as part of our services, and we are happy to discuss any potential projects with both internal and external researchers. 

The facility is concious of the overall sustainability work that is undertaken at Glasgow University, and we have now achieved a Silver LEAF award (Laboratory Efficiency Assessment Framework).

GLASGOW PROTEIN AND PEPTIDE INTEREST GROUP (GPIG) MEETINGS

GPIG is a meeting of likeminded scientists in Glasgow, and includes researchers from all over the University of Glasgow, including MVLS, School of Chemistry, CVR, SCMI, as well as the CRUK Beatson Institute and the University of Strathclyde. The ethos of the meeting is to discuss available methodology, establish new collaborations, and exchange ideas. The meetings are held three times per year, and is open to anyone local with an interest in protein and peptide research. If you are interested in joining us, please contact Prof. Helen Walden.

The next meeting will be held on the 19th March, 2024. The speakers include Dr Sarah Harris from the University of Leeds. Location to be confirmed. 

 RECENT PUBLICATIONS INVOLVING THE FACILITY

Cara Jackson & Rebecca Beveridge. Native Mass Spectrometry of Complexes Formed by Molecular Glues Revealed Stoichiometric Rearrangement of the DCAF15 E3 Ligase. Analyst, 2024.

Sandep Pal, Zandile Nare, Vincenzo A. Rao, Brian O. Smith, Ian Morrison, Edward A. Fitzgerald, Andrew Scott, Matilda J. Bingham, Thomas Pesnot. Accelerating BRPF1b hit identification with BioPhysical and Active Learning Screening (BioPALS). ChemMedChem, 2024. 

Sebastian Adam, Dazhong Zheng, Andreas Klein, Carsten Volz, William Mullen, Sally L. Shirran, Brian O. Smith, Olga V. Kalinina, Rolf Müller & Jesko Koehnke. Unusual peptide-binding proteins guide pyrroloindoline alkaloid formation in crocagin biosynthesis. Nature Chemistry, 2023.