School of Cancer Sciences

The University of Glasgow is providing data to train the AI, with Professor David Chang, UK project lead, involved in developing the algorithms.

PANCAIM kicked off in 2021 and aims to be the first to optimise and integrate pancreatic cancer genomics, imaging phenomics, and clinical parameters using artificial intelligence (AI).

Pancreatic cancer will soon be the second leading cause of cancer-related death in Western societies. Potential new detection techniques and treatments are emerging, but challenges remain; and for these new tools to be effective, it will be necessary to find patients earlier, select the right drug for the patient, and better follow the therapy.

PANCAIM, an EU H2020-funded research and innovation project, exploits the power of multi-modal Artificial Intelligence (AI) to tackle these challenges.

PANCAIM builds on four key concepts of AI in Healthcare: expert clinical expertise, high amounts of carefully documented real-world data, AI experts, and MedTech companies to bring AI to healthcare.

Alongside the input of the University of Glasgow and other collaborators, Partner Collective Minds Radiology has already developed the PANCAIM cloud repository, which collects and hosts a wide range of imaging, genomics, and clinical PDAC data and will be sustained for further research and clinical applications.

Six top-expert clinical partners are providing almost 6000 patient data sets, including data from patients in Scotland. Three partners offer strong expertise in healthcare AI across all the clinical modalities involved.

An intermediate milestone for the project is to develop uni-modal AI applications that, in a later stage, will be integrated and thoroughly validated. In year 2, the first AI unimodal AI algorithm was developed and published and has been demonstrated to detect small cancers on CT imaging that can easily be overlooked even by experienced radiologists.

PANCAIM has now exclusively implemented this AI algorithm via the teamplay digital health platform, a cloud platform owned by project partner Siemens Healthineers, which is already in use at thousands of hospitals worldwide. At a project meeting in Stockholm on May 9, the first AI-algorithm developed within the PANCAIM project was used on a real, new pancreatic cancer case at the Karolinska institute, paving the way towards widespread validation of the PANCAIM AI-algorithms in clinical routine settings. After 2.5 years of collaboration this first real application is a significant milestone for the project and pancreatic cancer research as a whole.

Professor David Chang, Professor of Surgical Oncology at the School of Cancer Sciences, University of Glasgow, said: “It is incredibly exciting to be part of this innovative consortium, and seeing the possibility of applying artificial intelligence algorithm to clinically generated data, such as radiology, pathology, and other experimental data such as molecular profiling, to help better manage patients  with pancreatic cancer..”

PANCAIM will now focus on upscaling unimodal AI algorithms, including for pathology and genomics, drive forward the development of multimodal AI models and start the clinical validation process. The ultimate objective is to implement these algorithms routinely in the clinical workflow for pancreatic cancer diagnosis and therapy monitoring, offering AI-based decision-making support to clinicians.

 

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First published: 25 October 2023