Dr Delyth Graham

  • Senior Lecturer (Institute of Cardiovascular & Medical Sciences)
  • Associate (School of Life Sciences)

Research interests

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Vaso-protective properties of maternal high density lipoprotein (HDL) in metabolic complications of pregnancy
    NHS Greater Glasgow and Clyde Endowment Funds
    2018 - 2019
     
  • Refinement in pre-clinical stroke research: investigation of morbidity and mortality and development of improved post-stroke care in rodents
    American College of Laboratory
    2015 - 2016
     
  • Investigation of Osteopontin as a candidate gene for left ventricular hypertrophy
    British Heart Foundation
    2014 - 2018
     
  • SysVasc
    European Commission
    2014 - 2018
     
  • Genetic, molecular and functional dissection of a novel pathway for hypertension: Uromodulin, renal function, sodium homeostasis and blood pressure.
    British Heart Foundation
    2013 - 2017
     
  • Abnormal uterine artery remodelling in the stroke-prone spontaneously hypertensive rat.
    Glasgow Children`s Hospital Charity
    2013 - 2013
     
  • The role of AMP-activated protein kinase in adipocyte glucose transport and insulin signalling - utilising a knockout mouse model
    Diabetes UK
    2012 - 2013
     
  • The mitochondrial-targeted antioxidant, MitoQ10: a novel therapeutic agent for cardiovascular disease.
    British Heart Foundation
    2012 - 2012
     
  • Angiotensin 1-9 and angiotensin 1-7: assessment of their mechanisms of action as counter-regulatory renin angiotensin system peptides in cardiovascular disease
    British Heart Foundation
    2011 - 2015
     
  • The role of AMP-activated protein kinase in adipocyte glucose transport and insulin signalling
    Diabetes UK
    2010 - 2013
     
  • Metabolic syndrome, hyperglycemia and experimental stroke
    Scottish Executive Health Department
    2009 - 2010
     
  • Functional characteristics of the Gstm1 deficiency in the stroke prone spontaneously hypertensive rat - in vitro and in vivo studies
    British Heart Foundation
    2004 - 2007
     

Publications

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Number of items: 65.

2018

Czesnikiewicz-Guzik, M., Nosalski, R., Mikolajczyk, T. P., Vidler, F., Dohnal, T., Dembowska, E., Graham, D. , Harrison, D. G. and Guzik, T. J. (2018) Th1 type immune responses to Porphyromonas gingivalis antigens exacerbate angiotensin II dependent hypertension and vascular dysfunction. British Journal of Pharmacology, (doi:10.1111/bph.14536) (PMID:30414380) (Early Online Publication)

Graham, L. A., Aman, A., Campbell, D. D. , Augley, J., Graham, D. , McBride, M. W. , Fraser, N. J., Ferreri, N. R., Dominiczak, A. F. and Padmanabhan, S. (2018) Salt stress in the renal tubules is linked to TAL specific expression of uromodulin and an upregulation of heat shock genes. Physiological Genomics, 50(11), pp. 964-972. (doi:10.1152/physiolgenomics.00057.2018) (PMID:30216136)

Olson, E., Pravenec, M., Landa, V., Koh-Tan, H. H. C., Dominiczak, A. F. , McBride, M. W. and Graham, D. (2018) Transgenic overexpression of glutathione S-transferase μ-type 1 reduces hypertension and oxidative stress in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, (doi:10.1097/HJH.0000000000001960) (PMID:30308595) (Early Online Publication)

Divorty, N., Milligan, G. , Graham, D. and Nicklin, S. A. (2018) The orphan receptor GPR35 contributes to angiotensin II–induced hypertension and cardiac dysfunction in mice. American Journal of Hypertension, 31(9), pp. 1049-1058. (doi:10.1093/ajh/hpy073) (PMID:29860395) (PMCID:PMC6077831)

Rajani, R. M. et al. (2018) Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats. Science Translational Medicine, 10(448), eaam9507. (doi:10.1126/scitranslmed.aam9507) (PMID:29973407)

Camargo, L. L. et al. (2018) Vascular Nox (NADPH oxidase) compartmentalization, protein hyperoxidation, and endoplasmic reticulum stress response in hypertension. Hypertension, 72(1), pp. 235-246. (doi:10.1161/HYPERTENSIONAHA.118.10824) (PMID:29844144)

Morgan, H. L., Butler, E., Ritchie, S., Herse, F., Dechend, R., Beattie, E., McBride, M. W. and Graham, D. (2018) Modeling superimposed preeclampsia using Ang II (Angiotensin II) infusion in pregnant stroke-prone spontaneously hypertensive rats. Hypertension, 72(1), pp. 208-218. (doi:10.1161/HYPERTENSIONAHA.118.10935) (PMID:29844145) (PMCID:PMC6012051)

Bailey, E. , McBride, M. W. , McClure, J. D. , Beattie, W., Graham, D. , Dominiczak, A. , Smith, C. and Wardlaw, J. (2018) Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease. Clinical Science, 132(12), pp. 1315-1328. (doi:10.1042/CS20171572) (PMID:29632138)

Montezano, A. C. et al. (2018) NADPH oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), e009388. (doi:10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)

Delles, C., Carrick, E., Graham, D. and Nicklin, S. A. (2018) Utilising proteomics to understand and define hypertension: where are we and where do we go? Expert Review of Proteomics, 15(7), pp. 581-592. (doi:10.1080/14789450.2018.1493927) (PMID:29999442) (PMCID:PMC6092739)

2017

Harvey, A. P., Montezano, A. C., Hood, K. Y., Lopes, R. A., Rios, F., Ceravolo, G., Graham, D. and Touyz, R. M. (2017) Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis. Life Sciences, 179, pp. 110-119. (doi:10.1016/j.lfs.2017.05.002) (PMID:28478264) (PMCID:5446265)

Koh-Tan, H.H. C., Dashti, M., Wang, T., Beattie, W., Mcclure, J. , Young, B., Dominiczak, A. F. , McBride, M. W. and Graham, D. (2017) Dissecting the genetic components of a quantitative trait locus for blood pressure and renal pathology on rat chromosome 3. Journal of Hypertension, 35(2), pp. 319-329. (doi:10.1097/HJH.0000000000001155) (PMID:27755386) (PMCID:PMC5214373)

Mancini, S. J., White, A. D., Bijland, S., Rutherford, C., Graham, D. , Richter, E. A., Viollet, B., Touyz, R. M. , Palmer, T. M. and Salt, I. P. (2017) Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptorassociated kinase-4 phosphorylation. Molecular and Cellular Endocrinology, 440, pp. 44-56. (doi:10.1016/j.mce.2016.11.010) (PMID:27840174) (PMCID:PMC5228585)

2016

Small, H. Y., Nosalski, R., Morgan, H., Beattie, E., Guzik, T., Graham, D. and Delles, C. (2016) The role of tumor necrosis factor-α and natural killer cells in uterine artery function and pregnancy outcome in the stroke prone spontaneously hypertensive rat. Hypertension, 68(5), pp. 1298-1307. (doi:10.1161/HYPERTENSIONAHA.116.07933) (PMID:27733586) (PMCID:PMC5058643)

Morgan, H., Small, H.Y., Beattie, E., McBride, M.W. and Graham, D. (2016) [OP.5D.02] Transcriptomic changes in early pregnancy-associated uterine artery remodelling in stroke prone spontaneously hypertensive rat. Journal of Hypertension, 34(S2), e63-e63. (doi:10.1097/01.hjh.0000491501.79443.05) (PMID:27508758)

Wan Sulaiman, W.N., Caslake, M.J., Delles, C. , Karlsson, H., Mulder, M.T., Graham, D. and Freeman, D.J. (2016) Does high-density lipoprotein protect vascular function in healthy pregnancy? Clinical Science, 130(7), pp. 491-497. (doi:10.1042/cs20150475) (PMID:26888561)

Small, H. Y., Morgan, H., Beattie, E., Griffin, S., Indahl, M., Delles, C. and Graham, D. (2016) Abnormal uterine artery remodelling in the stroke prone spontaneously hypertensive rat. Placenta, 37, pp. 34-44. (doi:10.1016/j.placenta.2015.10.022) (PMID:26612342) (PMCID:PMC4721537)

2015

Zoccarato, A. et al. (2015) Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2. Circulation Research, 117, pp. 707-719. (doi:10.1161/CIRCRESAHA.114.305892) (PMID:26243800)

Menni, C. et al. (2015) Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate. Hypertension, 66, pp. 422-429. (doi:10.1161/HYPERTENSIONAHA.115.05544) (PMID:26034203) (PMCID:PMC4490909)

Skogstrand, T., Leh, S., McClure, J. , Dashti, M., Iversen, B. M., Graham, D. , McBride, M. and Hultström, M. (2015) Identification of a common molecular pathway in hypertensive renal damage. Journal of Hypertension, 33(3), pp. 584-596. (doi:10.1097/HJH.0000000000000395) (PMID:25380151)

Lopez, L. M. et al. (2015) Genes from a translational analysis support a multifactorial nature of white matter hyperintensities. Stroke, 46(2), pp. 341-347. (doi:10.1161/STROKEAHA.114.007649) (PMID:25586835) (PMCID:PMC4306534)

2014

Lee, K. M., Danuser, R., Stein, J. V., Graham, D. , Nibbs, R. J.B. and Graham, G. J. (2014) The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density. EMBO Journal, 33(21), pp. 2564-2580. (doi:10.15252/embj.201488887)

Sampson, A. K., Mohammed, D., Beattie, W., Graham, D. , Kenyon, C. J., Al-Dujaili, E. A.S., Guryev, V., McBride, M. W. and Dominiczak, A. F. (2014) Introgressed chromosome 2 quantitative trait loci restores aldosterone regulation and reduces response to salt in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 32(10), pp. 2013-2021. (doi:10.1097/HJH.0000000000000300)

Graham, L. A. et al. (2014) Validation of uromodulin as a candidate gene for human essential hypertension. Hypertension, 63(3), pp. 551-558. (doi:10.1161/HYPERTENSIONAHA.113.01423)

McLachlan, J., Beattie, E., Murphy, M. P., Koh-Tan, C. H.H., Olson, E., Beattie, W., Dominiczak, A. F. , Nicklin, S. A. and Graham, D. (2014) Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function. Journal of Hypertension, 32(3), pp. 555-564. (doi:10.1097/HJH.0000000000000054)

Bailey, E. L. , McBride, M. W. , Crawford, W., McClure, J. D. , Graham, D. , Dominiczak, A. F. , Sudlow, C. L.M., Smith, C. and Wardlaw, J. M. (2014) Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke. Neuropathology and Applied Neurobiology, 40(7), pp. 855-872. (doi:10.1111/nan.12116)

Baud, A. et al. (2014) Genomes and phenomes of a population of outbred rats and its progenitors. Scientific Data, 1, 140011. (doi:10.1038/sdata.2014.11) (PMID:25977769) (PMCID:PMC4381735)

Padmanabhan, S. , Graham, L., Ferreri, N. R., Graham, D. , McBride, M. and Dominiczak, A. (2014) Uromodulin, an emerging novel pathway for blood pressure regulation and hypertension. Hypertension, 64(5), pp. 918-923. (doi:10.1161/HYPERTENSIONAHA.114.03132)

Sampson, A. K., Andrews, K. L., Graham, D. , McBride, M. W. , Head, G. A., Thomas, M. C., Chin-Dusting, J. P.F., Dominiczak, A. F. and Jennings, G. L. (2014) Origin of the y chromosome influences intrarenal vascular responsiveness to angiotensin i and angiotensin (1-7) in stroke-prone spontaneously hypertensive rats. Hypertension, 64(6), pp. 1376-1383. (doi:10.1161/HYPERTENSIONAHA.114.03756)

2013

Montezano, A. C., Yusuf, H., Graham, D. and Touyz, R. M. (2013) Redox-sensitive osteogenic factors as novel mediators of vascular injury in hypertension. Hypertension, 62(3 Sup), A490.

Baud, A. et al. (2013) Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nature Genetics, 45(7), pp. 767-775. (doi:10.1038/ng.2644)

Brittain, J.F. et al. (2013) An MRI-histological study of white matter in stroke-free SHRSP. Journal of Cerebral Blood Flow and Metabolism, 33(5), pp. 760-763. (doi:10.1038/jcbfm.2013.14)

Koh-Tan, H.H. C., McBride, M. W. , McClure, J. D. , Beattie, E., Young, B., Dominiczak, A. F. and Graham, D. (2013) Interaction between chromosome 2 and 3 regulates pulse pressure in the stroke-prone spontaneously hypertensive rat. Hypertension, 62(1), pp. 33-40. (doi:10.1161/HYPERTENSIONAHA.111.00814)

Tarr, D., Graham, D. , Roy, L.A., Holmes, W.M., McCabe, C. , Macrae, I.M., Muir, K.W. and Dewar, D. (2013) Hyperglycemia accelerates apparent diffusion coefficient-defined lesion growth after focal cerebral ischemia in rats with and without features of metabolic syndrome. Journal of Cerebral Blood Flow and Metabolism, 33(10), pp. 1556-1563. (doi:10.1038/jcbfm.2013.107)

2012

Reid, E., Graham, D. , Lopez-Gonzalez, M. R., Holmes, W. M., Macrae, I. M. and McCabe, C. (2012) Penumbra detection using PWI/DWI mismatch MRI in a rat stroke model with and without comorbidity: comparison of methods. Journal of Cerebral Blood Flow and Metabolism, 32(9), pp. 1765-1777. (doi:10.1038/jcbfm.2012.69) (PMID:22669479) (PMCID:PMC3434632)

Flores, M., Graham, D. , Dominiczak, A.F. , Milligan, G. , Baker, A.H. and Nicklin, S.A. (2012) Angiotensin-(1-9) antagonises Angiotensin II-induced cardiac remodeling via the angiotensin type 2 receptor. Proceedings of the Physiological Society, 27, C1.

Flores, M., Work, L.M. , Douglas, K., Denby, L., Dominiczak, A.F. , Graham, D. and Nicklin, S.A. (2012) Angiotensin-(1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor. Hypertension, 59(2), pp. 300-307. (doi:10.1161/HYPERTENSIONAHA.111.177485)

Flores, M., Graham, D. , Dominiczak, A. F. , Milligan, G. , Baker, A. H. and Nicklin, S. A. (2012) Abstract 231: angiotensin-(1-9) antagonises cardiac remodelling in a mouse model of Angiotensin Ii-induced hypertension. Hypertension, 60, A231.

Xu, H. et al. (2012) Upregulation of junctional adhesion molecule-A is a putative prognostic marker of hypertension. Cardiovascular Research, 96(3), pp. 552-560. (doi:10.1093/cvr/cvs273)

2011

Bailey, E.L. , Wardlaw, J.M., Graham, D. , Dominiczak, A.F. , Sudlow, C.L.M. and Smith, C. (2011) Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats. Neuropathology and Applied Neurobiology, 37(7), pp. 711-726. (doi:10.1111/j.1365-2990.2011.01170.x)

Yogi, A., Callera, G.E., Aranha, A.B., Antunes, T.T., Graham, D. , McBride, M. , Dominiczak, A. and Touyz, R.M. (2011) Sphingosine-1-Phosphate-Induced Inflammation Involves Receptor Tyrosine Kinase Transactivation in Vascular Cells: Upregulation in Hypertension. Hypertension, 57(4), pp. 809-818. (doi:10.1161/HYPERTENSIONAHA.110.162719)

2010

Greig, J.A., Shirley, R., Graham, D. , Denby, L., Dominiczak, A.F. , Work, L.M. and Baker, A. (2010) Vascular-targeting anti-oxidant therapy in a model of hypertension and stroke. Journal of Cardiovascular Pharmacology, 56(6), pp. 642-650. (doi:10.1097/FJC.0b013e3181f8f19f)

Hopcroft, L. E.M. , McBride, M. W. , Harris, K. J., Sampson, A. K., McClure, J. D. , Graham, D. , Young, G., Holyoake, T. L., Girolami, M. A. and Dominiczak, A. F. (2010) Predictive response-relevant clustering of expression data provides insights into disease processes. Nucleic Acids Research, 38(20), pp. 6831-6840. (doi:10.1093/nar/gkq550)

Delles, C. , McBride, M.W. , Graham, D. , Padmanabhan, S. and Dominiczak, A.F. (2010) Genetics of hypertension: from experimental animals to humans. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1802(12), pp. 1299-1308. (doi:10.1016/j.bbadis.2009.12.006)

Graham, D. , Koh-Tan, H. H. C. and Dominiczak, A. F. (2010) Reduced renal glutathione S-transferase mu type 1 expression in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 28(3), p. 634. (doi:10.1097/HJH.0b013e328336902d)

McBride, M. , Hopcroft, L. , Harris, K., McClure, J. , Graham, D. , Girolami, M. and Dominiczak, M. (2010) Insights into Salt-Sensitive Hypertension Using Response-Relevant Clustering. In: 20th Annual Meeting of the European Society of Hypertension, Oslo, Norway, 18-21 June, E342-E342.

McCabe, C. , Gallagher, L., Macrae, I.M., Gsell, W., Graham, D. and Dominiczak, A.F. (2010) Response to letter by Yao (Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats). Stroke, 41(4), E198-E199. (doi:10.1161/STROKEAHA.109.575704)

Padmanabhan, S. et al. (2010) Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genetics, 6(10), e1001177. (doi:10.1371/journal.pgen.1001177)

2009

McCabe, C. , Gallagher, L., Gsell, W., Graham, D. , Dominiczak, A. F. and Macrae, I. M. (2009) Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats. Stroke, 40(12), pp. 3864-3868. (doi:10.1161/STROKEAHA.109.559021)

Graham, D. , Huynh, N.N., Hamilton, C.A., Beattie, E.C., Smith, R.A.J., Cocheme, H.M., Murphy, M.P. and Dominiczak, A.F. (2009) Mitochondria-targeted antioxidant MitoQ(10) improves endothelial function and attenuates cardiac hypertrophy. Hypertension, 54(2), 322-U233. (doi:10.1161/HYPERTENSIONAHA.109.130351)

Johannesson, M. et al. (2009) A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: The NIH heterogeneous stock. Genome Research, 19(1), pp. 150-158. (doi:10.1101/gr.081497.108)

Koh-Tan, H., Graham, D. , Hamilton, C., Nicoll, G., Fields, L., McBride, M. , Young, B., Young, B. and Dominiczak, A. (2009) Renal and vascular glutathione S-transferase mu is not affected by pharmacological intervention to reduce systolic blood pressure. Journal of Hypertension, 27(8), pp. 1575-1584. (doi:10.1097/HJH.0b013e32832cc5a1)

Masson, R. et al. (2009) Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2. Hypertension, 53(4), pp. 694-700. (doi:10.1161/HYPERTENSIONAHA.108.122333)

Xu, A., Chamberlain, J., Francis, S., Brookes, Z., Shaw, G., Graham, D. , Alp, N.J., Dower, S. and Crossman, D.C. (2009) Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding. PLoS ONE, 4(4), e5073. (doi:10.1371/journal.pone.0005073)

2008

Miller, W., Graham, D. , Douglas, K., MacKenzie, R. and Dominiczak, A. (2008) Metabolic phenotypes in SHRSP and chromosome 2 congenic strains. Journal of Human Hypertension, 22(10), pp. 736-737.

Miller, W., Graham, D. , Douglas, K., Mackenzie, R., Huynh, N. and Dominiczak, A. (2008) Characterisation of metabolic phenotypes in the SHRSP using chromosome 2 congenic strains. Journal of Hypertension, 26(Suppl.), S340-S341.

Tian, T., McBride, M.W. , Graham, D. , Touyz, R. and Dominiczak, A.F. (2008) A systems biology approach for the sphingosine-1-phosphate signal transduction in vascular smooth muscle cell. Journal of Hypertension, 26(Suppl.), S148-S148.

Tonyz, R., Aranha, A., Yogi, A., Graham, D. , McBride, M. , Callera, G., Montezano, A., Coimbra, T. and Dominiczak, A. (2008) Increased vascular sphingosine-1-phosphate signaling in SHRSP is due to post-receptor mechanisms. Journal of Hypertension, 26(Suppl.), S329-S329.

2007

Graham, D. et al. (2007) Candidate genes that determine response to salt in the stroke-prone spontaneously hypertensive rat - Congenic analysis. Hypertension, 50(6), pp. 1134-1141. (doi:10.1161/HYPERTENSIONAHA.107.095349)

2005

Dominiczak, A. F. , Graham, D. , McBride, M. W. , Brain, N. J.R., Lee, W. K., Charchar, F. J., Tomaszewski, M., Delles, C. and Hamilton, C. A. (2005) Corcoran Lecture. Cardiovascular genomics and oxidative stress. Hypertension, 45(4), pp. 636-642. (doi:10.1161/01.HYP.0000154253.53134.09)

2004

McBride, M.W. , Charchar, F.J., Graham, D. , Miller, W.H., Strahorn, P., Carr, F.J. and Dominiczak, A.F. (2004) Functional genomics in rodent models of hypertension. Journal of Physiology, 554(1), pp. 56-63. (doi:10.1113/jphysiol.2003.049361)

Denby, L., Work, L.M., Graham, D. , Hsu, C., Von Seggern, D.J., Nicklin, S.A. and Baker, A.H. (2004) Adenoviral serotype 5 vectors pseudotyped with fibers from subgroup D show modified tropism in vitro and in vivo. Human Gene Therapy, 15(11), pp. 1054-1064.

1999

Anderson, N. H., Devlin, A. M., Graham, D. , Morton, J. J., Hamilton, C. A., Reid, J. L., Schork, N. J. and Dominiczak, A. F. (1999) Telemetry for cardiovascular monitoring in a pharmacological study: new approaches to data analysis. Hypertension, 33(1), pp. 248-255. (doi:10.1161/01.HYP.33.1.248) (PMID:9931112)

1998

Devlin, A. M., Brosnan, M. J., Graham, D. , Morton, J. J., McPhaden, A. R., McIntyre, M., Hamilton, C. A., Reid, J. L. and Dominiczak, A. F. (1998) Vascular smooth muscle cell polyploidy and cardiomyocyte hypertrophy due to chronic NOS inhibition in vivo. American Journal of Physiology: Heart and Circulatory Physiology, 274(1), H52-H59. (PMID:9458851)

1997

Dominiczak, A. F. , Devlin, A. M., Brosnan, M. J., Anderson, N. H., Graham, D. , Clark, J. S., McPhaden, A., Hamilton, C. A. and Reid, J. L. (1997) Left ventricular hypertrophy and arterial blood pressure in experimental models of hypertension. Advances in Experimental Medicine and Biology, 432, pp. 23-33. (doi:10.1007/978-1-4615-5385-4_3) (PMID:9433508)

This list was generated on Wed Dec 12 20:09:09 2018 GMT.
Number of items: 65.

Articles

Czesnikiewicz-Guzik, M., Nosalski, R., Mikolajczyk, T. P., Vidler, F., Dohnal, T., Dembowska, E., Graham, D. , Harrison, D. G. and Guzik, T. J. (2018) Th1 type immune responses to Porphyromonas gingivalis antigens exacerbate angiotensin II dependent hypertension and vascular dysfunction. British Journal of Pharmacology, (doi:10.1111/bph.14536) (PMID:30414380) (Early Online Publication)

Graham, L. A., Aman, A., Campbell, D. D. , Augley, J., Graham, D. , McBride, M. W. , Fraser, N. J., Ferreri, N. R., Dominiczak, A. F. and Padmanabhan, S. (2018) Salt stress in the renal tubules is linked to TAL specific expression of uromodulin and an upregulation of heat shock genes. Physiological Genomics, 50(11), pp. 964-972. (doi:10.1152/physiolgenomics.00057.2018) (PMID:30216136)

Olson, E., Pravenec, M., Landa, V., Koh-Tan, H. H. C., Dominiczak, A. F. , McBride, M. W. and Graham, D. (2018) Transgenic overexpression of glutathione S-transferase μ-type 1 reduces hypertension and oxidative stress in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, (doi:10.1097/HJH.0000000000001960) (PMID:30308595) (Early Online Publication)

Divorty, N., Milligan, G. , Graham, D. and Nicklin, S. A. (2018) The orphan receptor GPR35 contributes to angiotensin II–induced hypertension and cardiac dysfunction in mice. American Journal of Hypertension, 31(9), pp. 1049-1058. (doi:10.1093/ajh/hpy073) (PMID:29860395) (PMCID:PMC6077831)

Rajani, R. M. et al. (2018) Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats. Science Translational Medicine, 10(448), eaam9507. (doi:10.1126/scitranslmed.aam9507) (PMID:29973407)

Camargo, L. L. et al. (2018) Vascular Nox (NADPH oxidase) compartmentalization, protein hyperoxidation, and endoplasmic reticulum stress response in hypertension. Hypertension, 72(1), pp. 235-246. (doi:10.1161/HYPERTENSIONAHA.118.10824) (PMID:29844144)

Morgan, H. L., Butler, E., Ritchie, S., Herse, F., Dechend, R., Beattie, E., McBride, M. W. and Graham, D. (2018) Modeling superimposed preeclampsia using Ang II (Angiotensin II) infusion in pregnant stroke-prone spontaneously hypertensive rats. Hypertension, 72(1), pp. 208-218. (doi:10.1161/HYPERTENSIONAHA.118.10935) (PMID:29844145) (PMCID:PMC6012051)

Bailey, E. , McBride, M. W. , McClure, J. D. , Beattie, W., Graham, D. , Dominiczak, A. , Smith, C. and Wardlaw, J. (2018) Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease. Clinical Science, 132(12), pp. 1315-1328. (doi:10.1042/CS20171572) (PMID:29632138)

Montezano, A. C. et al. (2018) NADPH oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7(12), e009388. (doi:10.1161/JAHA.118.009388) (PMID:29907654) (PMCID:PMC6220544)

Delles, C., Carrick, E., Graham, D. and Nicklin, S. A. (2018) Utilising proteomics to understand and define hypertension: where are we and where do we go? Expert Review of Proteomics, 15(7), pp. 581-592. (doi:10.1080/14789450.2018.1493927) (PMID:29999442) (PMCID:PMC6092739)

Harvey, A. P., Montezano, A. C., Hood, K. Y., Lopes, R. A., Rios, F., Ceravolo, G., Graham, D. and Touyz, R. M. (2017) Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis. Life Sciences, 179, pp. 110-119. (doi:10.1016/j.lfs.2017.05.002) (PMID:28478264) (PMCID:5446265)

Koh-Tan, H.H. C., Dashti, M., Wang, T., Beattie, W., Mcclure, J. , Young, B., Dominiczak, A. F. , McBride, M. W. and Graham, D. (2017) Dissecting the genetic components of a quantitative trait locus for blood pressure and renal pathology on rat chromosome 3. Journal of Hypertension, 35(2), pp. 319-329. (doi:10.1097/HJH.0000000000001155) (PMID:27755386) (PMCID:PMC5214373)

Mancini, S. J., White, A. D., Bijland, S., Rutherford, C., Graham, D. , Richter, E. A., Viollet, B., Touyz, R. M. , Palmer, T. M. and Salt, I. P. (2017) Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptorassociated kinase-4 phosphorylation. Molecular and Cellular Endocrinology, 440, pp. 44-56. (doi:10.1016/j.mce.2016.11.010) (PMID:27840174) (PMCID:PMC5228585)

Small, H. Y., Nosalski, R., Morgan, H., Beattie, E., Guzik, T., Graham, D. and Delles, C. (2016) The role of tumor necrosis factor-α and natural killer cells in uterine artery function and pregnancy outcome in the stroke prone spontaneously hypertensive rat. Hypertension, 68(5), pp. 1298-1307. (doi:10.1161/HYPERTENSIONAHA.116.07933) (PMID:27733586) (PMCID:PMC5058643)

Morgan, H., Small, H.Y., Beattie, E., McBride, M.W. and Graham, D. (2016) [OP.5D.02] Transcriptomic changes in early pregnancy-associated uterine artery remodelling in stroke prone spontaneously hypertensive rat. Journal of Hypertension, 34(S2), e63-e63. (doi:10.1097/01.hjh.0000491501.79443.05) (PMID:27508758)

Wan Sulaiman, W.N., Caslake, M.J., Delles, C. , Karlsson, H., Mulder, M.T., Graham, D. and Freeman, D.J. (2016) Does high-density lipoprotein protect vascular function in healthy pregnancy? Clinical Science, 130(7), pp. 491-497. (doi:10.1042/cs20150475) (PMID:26888561)

Small, H. Y., Morgan, H., Beattie, E., Griffin, S., Indahl, M., Delles, C. and Graham, D. (2016) Abnormal uterine artery remodelling in the stroke prone spontaneously hypertensive rat. Placenta, 37, pp. 34-44. (doi:10.1016/j.placenta.2015.10.022) (PMID:26612342) (PMCID:PMC4721537)

Zoccarato, A. et al. (2015) Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2. Circulation Research, 117, pp. 707-719. (doi:10.1161/CIRCRESAHA.114.305892) (PMID:26243800)

Menni, C. et al. (2015) Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate. Hypertension, 66, pp. 422-429. (doi:10.1161/HYPERTENSIONAHA.115.05544) (PMID:26034203) (PMCID:PMC4490909)

Skogstrand, T., Leh, S., McClure, J. , Dashti, M., Iversen, B. M., Graham, D. , McBride, M. and Hultström, M. (2015) Identification of a common molecular pathway in hypertensive renal damage. Journal of Hypertension, 33(3), pp. 584-596. (doi:10.1097/HJH.0000000000000395) (PMID:25380151)

Lopez, L. M. et al. (2015) Genes from a translational analysis support a multifactorial nature of white matter hyperintensities. Stroke, 46(2), pp. 341-347. (doi:10.1161/STROKEAHA.114.007649) (PMID:25586835) (PMCID:PMC4306534)

Lee, K. M., Danuser, R., Stein, J. V., Graham, D. , Nibbs, R. J.B. and Graham, G. J. (2014) The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density. EMBO Journal, 33(21), pp. 2564-2580. (doi:10.15252/embj.201488887)

Sampson, A. K., Mohammed, D., Beattie, W., Graham, D. , Kenyon, C. J., Al-Dujaili, E. A.S., Guryev, V., McBride, M. W. and Dominiczak, A. F. (2014) Introgressed chromosome 2 quantitative trait loci restores aldosterone regulation and reduces response to salt in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 32(10), pp. 2013-2021. (doi:10.1097/HJH.0000000000000300)

Graham, L. A. et al. (2014) Validation of uromodulin as a candidate gene for human essential hypertension. Hypertension, 63(3), pp. 551-558. (doi:10.1161/HYPERTENSIONAHA.113.01423)

McLachlan, J., Beattie, E., Murphy, M. P., Koh-Tan, C. H.H., Olson, E., Beattie, W., Dominiczak, A. F. , Nicklin, S. A. and Graham, D. (2014) Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function. Journal of Hypertension, 32(3), pp. 555-564. (doi:10.1097/HJH.0000000000000054)

Bailey, E. L. , McBride, M. W. , Crawford, W., McClure, J. D. , Graham, D. , Dominiczak, A. F. , Sudlow, C. L.M., Smith, C. and Wardlaw, J. M. (2014) Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke. Neuropathology and Applied Neurobiology, 40(7), pp. 855-872. (doi:10.1111/nan.12116)

Baud, A. et al. (2014) Genomes and phenomes of a population of outbred rats and its progenitors. Scientific Data, 1, 140011. (doi:10.1038/sdata.2014.11) (PMID:25977769) (PMCID:PMC4381735)

Padmanabhan, S. , Graham, L., Ferreri, N. R., Graham, D. , McBride, M. and Dominiczak, A. (2014) Uromodulin, an emerging novel pathway for blood pressure regulation and hypertension. Hypertension, 64(5), pp. 918-923. (doi:10.1161/HYPERTENSIONAHA.114.03132)

Sampson, A. K., Andrews, K. L., Graham, D. , McBride, M. W. , Head, G. A., Thomas, M. C., Chin-Dusting, J. P.F., Dominiczak, A. F. and Jennings, G. L. (2014) Origin of the y chromosome influences intrarenal vascular responsiveness to angiotensin i and angiotensin (1-7) in stroke-prone spontaneously hypertensive rats. Hypertension, 64(6), pp. 1376-1383. (doi:10.1161/HYPERTENSIONAHA.114.03756)

Montezano, A. C., Yusuf, H., Graham, D. and Touyz, R. M. (2013) Redox-sensitive osteogenic factors as novel mediators of vascular injury in hypertension. Hypertension, 62(3 Sup), A490.

Baud, A. et al. (2013) Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nature Genetics, 45(7), pp. 767-775. (doi:10.1038/ng.2644)

Brittain, J.F. et al. (2013) An MRI-histological study of white matter in stroke-free SHRSP. Journal of Cerebral Blood Flow and Metabolism, 33(5), pp. 760-763. (doi:10.1038/jcbfm.2013.14)

Koh-Tan, H.H. C., McBride, M. W. , McClure, J. D. , Beattie, E., Young, B., Dominiczak, A. F. and Graham, D. (2013) Interaction between chromosome 2 and 3 regulates pulse pressure in the stroke-prone spontaneously hypertensive rat. Hypertension, 62(1), pp. 33-40. (doi:10.1161/HYPERTENSIONAHA.111.00814)

Tarr, D., Graham, D. , Roy, L.A., Holmes, W.M., McCabe, C. , Macrae, I.M., Muir, K.W. and Dewar, D. (2013) Hyperglycemia accelerates apparent diffusion coefficient-defined lesion growth after focal cerebral ischemia in rats with and without features of metabolic syndrome. Journal of Cerebral Blood Flow and Metabolism, 33(10), pp. 1556-1563. (doi:10.1038/jcbfm.2013.107)

Reid, E., Graham, D. , Lopez-Gonzalez, M. R., Holmes, W. M., Macrae, I. M. and McCabe, C. (2012) Penumbra detection using PWI/DWI mismatch MRI in a rat stroke model with and without comorbidity: comparison of methods. Journal of Cerebral Blood Flow and Metabolism, 32(9), pp. 1765-1777. (doi:10.1038/jcbfm.2012.69) (PMID:22669479) (PMCID:PMC3434632)

Flores, M., Graham, D. , Dominiczak, A.F. , Milligan, G. , Baker, A.H. and Nicklin, S.A. (2012) Angiotensin-(1-9) antagonises Angiotensin II-induced cardiac remodeling via the angiotensin type 2 receptor. Proceedings of the Physiological Society, 27, C1.

Flores, M., Work, L.M. , Douglas, K., Denby, L., Dominiczak, A.F. , Graham, D. and Nicklin, S.A. (2012) Angiotensin-(1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor. Hypertension, 59(2), pp. 300-307. (doi:10.1161/HYPERTENSIONAHA.111.177485)

Flores, M., Graham, D. , Dominiczak, A. F. , Milligan, G. , Baker, A. H. and Nicklin, S. A. (2012) Abstract 231: angiotensin-(1-9) antagonises cardiac remodelling in a mouse model of Angiotensin Ii-induced hypertension. Hypertension, 60, A231.

Xu, H. et al. (2012) Upregulation of junctional adhesion molecule-A is a putative prognostic marker of hypertension. Cardiovascular Research, 96(3), pp. 552-560. (doi:10.1093/cvr/cvs273)

Bailey, E.L. , Wardlaw, J.M., Graham, D. , Dominiczak, A.F. , Sudlow, C.L.M. and Smith, C. (2011) Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats. Neuropathology and Applied Neurobiology, 37(7), pp. 711-726. (doi:10.1111/j.1365-2990.2011.01170.x)

Yogi, A., Callera, G.E., Aranha, A.B., Antunes, T.T., Graham, D. , McBride, M. , Dominiczak, A. and Touyz, R.M. (2011) Sphingosine-1-Phosphate-Induced Inflammation Involves Receptor Tyrosine Kinase Transactivation in Vascular Cells: Upregulation in Hypertension. Hypertension, 57(4), pp. 809-818. (doi:10.1161/HYPERTENSIONAHA.110.162719)

Greig, J.A., Shirley, R., Graham, D. , Denby, L., Dominiczak, A.F. , Work, L.M. and Baker, A. (2010) Vascular-targeting anti-oxidant therapy in a model of hypertension and stroke. Journal of Cardiovascular Pharmacology, 56(6), pp. 642-650. (doi:10.1097/FJC.0b013e3181f8f19f)

Hopcroft, L. E.M. , McBride, M. W. , Harris, K. J., Sampson, A. K., McClure, J. D. , Graham, D. , Young, G., Holyoake, T. L., Girolami, M. A. and Dominiczak, A. F. (2010) Predictive response-relevant clustering of expression data provides insights into disease processes. Nucleic Acids Research, 38(20), pp. 6831-6840. (doi:10.1093/nar/gkq550)

Delles, C. , McBride, M.W. , Graham, D. , Padmanabhan, S. and Dominiczak, A.F. (2010) Genetics of hypertension: from experimental animals to humans. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1802(12), pp. 1299-1308. (doi:10.1016/j.bbadis.2009.12.006)

Graham, D. , Koh-Tan, H. H. C. and Dominiczak, A. F. (2010) Reduced renal glutathione S-transferase mu type 1 expression in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 28(3), p. 634. (doi:10.1097/HJH.0b013e328336902d)

McCabe, C. , Gallagher, L., Macrae, I.M., Gsell, W., Graham, D. and Dominiczak, A.F. (2010) Response to letter by Yao (Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats). Stroke, 41(4), E198-E199. (doi:10.1161/STROKEAHA.109.575704)

Padmanabhan, S. et al. (2010) Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genetics, 6(10), e1001177. (doi:10.1371/journal.pgen.1001177)

McCabe, C. , Gallagher, L., Gsell, W., Graham, D. , Dominiczak, A. F. and Macrae, I. M. (2009) Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats. Stroke, 40(12), pp. 3864-3868. (doi:10.1161/STROKEAHA.109.559021)

Graham, D. , Huynh, N.N., Hamilton, C.A., Beattie, E.C., Smith, R.A.J., Cocheme, H.M., Murphy, M.P. and Dominiczak, A.F. (2009) Mitochondria-targeted antioxidant MitoQ(10) improves endothelial function and attenuates cardiac hypertrophy. Hypertension, 54(2), 322-U233. (doi:10.1161/HYPERTENSIONAHA.109.130351)

Johannesson, M. et al. (2009) A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: The NIH heterogeneous stock. Genome Research, 19(1), pp. 150-158. (doi:10.1101/gr.081497.108)

Koh-Tan, H., Graham, D. , Hamilton, C., Nicoll, G., Fields, L., McBride, M. , Young, B., Young, B. and Dominiczak, A. (2009) Renal and vascular glutathione S-transferase mu is not affected by pharmacological intervention to reduce systolic blood pressure. Journal of Hypertension, 27(8), pp. 1575-1584. (doi:10.1097/HJH.0b013e32832cc5a1)

Masson, R. et al. (2009) Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2. Hypertension, 53(4), pp. 694-700. (doi:10.1161/HYPERTENSIONAHA.108.122333)

Xu, A., Chamberlain, J., Francis, S., Brookes, Z., Shaw, G., Graham, D. , Alp, N.J., Dower, S. and Crossman, D.C. (2009) Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding. PLoS ONE, 4(4), e5073. (doi:10.1371/journal.pone.0005073)

Miller, W., Graham, D. , Douglas, K., MacKenzie, R. and Dominiczak, A. (2008) Metabolic phenotypes in SHRSP and chromosome 2 congenic strains. Journal of Human Hypertension, 22(10), pp. 736-737.

Miller, W., Graham, D. , Douglas, K., Mackenzie, R., Huynh, N. and Dominiczak, A. (2008) Characterisation of metabolic phenotypes in the SHRSP using chromosome 2 congenic strains. Journal of Hypertension, 26(Suppl.), S340-S341.

Tian, T., McBride, M.W. , Graham, D. , Touyz, R. and Dominiczak, A.F. (2008) A systems biology approach for the sphingosine-1-phosphate signal transduction in vascular smooth muscle cell. Journal of Hypertension, 26(Suppl.), S148-S148.

Tonyz, R., Aranha, A., Yogi, A., Graham, D. , McBride, M. , Callera, G., Montezano, A., Coimbra, T. and Dominiczak, A. (2008) Increased vascular sphingosine-1-phosphate signaling in SHRSP is due to post-receptor mechanisms. Journal of Hypertension, 26(Suppl.), S329-S329.

Graham, D. et al. (2007) Candidate genes that determine response to salt in the stroke-prone spontaneously hypertensive rat - Congenic analysis. Hypertension, 50(6), pp. 1134-1141. (doi:10.1161/HYPERTENSIONAHA.107.095349)

Dominiczak, A. F. , Graham, D. , McBride, M. W. , Brain, N. J.R., Lee, W. K., Charchar, F. J., Tomaszewski, M., Delles, C. and Hamilton, C. A. (2005) Corcoran Lecture. Cardiovascular genomics and oxidative stress. Hypertension, 45(4), pp. 636-642. (doi:10.1161/01.HYP.0000154253.53134.09)

McBride, M.W. , Charchar, F.J., Graham, D. , Miller, W.H., Strahorn, P., Carr, F.J. and Dominiczak, A.F. (2004) Functional genomics in rodent models of hypertension. Journal of Physiology, 554(1), pp. 56-63. (doi:10.1113/jphysiol.2003.049361)

Denby, L., Work, L.M., Graham, D. , Hsu, C., Von Seggern, D.J., Nicklin, S.A. and Baker, A.H. (2004) Adenoviral serotype 5 vectors pseudotyped with fibers from subgroup D show modified tropism in vitro and in vivo. Human Gene Therapy, 15(11), pp. 1054-1064.

Anderson, N. H., Devlin, A. M., Graham, D. , Morton, J. J., Hamilton, C. A., Reid, J. L., Schork, N. J. and Dominiczak, A. F. (1999) Telemetry for cardiovascular monitoring in a pharmacological study: new approaches to data analysis. Hypertension, 33(1), pp. 248-255. (doi:10.1161/01.HYP.33.1.248) (PMID:9931112)

Devlin, A. M., Brosnan, M. J., Graham, D. , Morton, J. J., McPhaden, A. R., McIntyre, M., Hamilton, C. A., Reid, J. L. and Dominiczak, A. F. (1998) Vascular smooth muscle cell polyploidy and cardiomyocyte hypertrophy due to chronic NOS inhibition in vivo. American Journal of Physiology: Heart and Circulatory Physiology, 274(1), H52-H59. (PMID:9458851)

Dominiczak, A. F. , Devlin, A. M., Brosnan, M. J., Anderson, N. H., Graham, D. , Clark, J. S., McPhaden, A., Hamilton, C. A. and Reid, J. L. (1997) Left ventricular hypertrophy and arterial blood pressure in experimental models of hypertension. Advances in Experimental Medicine and Biology, 432, pp. 23-33. (doi:10.1007/978-1-4615-5385-4_3) (PMID:9433508)

Conference Proceedings

McBride, M. , Hopcroft, L. , Harris, K., McClure, J. , Graham, D. , Girolami, M. and Dominiczak, M. (2010) Insights into Salt-Sensitive Hypertension Using Response-Relevant Clustering. In: 20th Annual Meeting of the European Society of Hypertension, Oslo, Norway, 18-21 June, E342-E342.

This list was generated on Wed Dec 12 20:09:09 2018 GMT.