Dr Delyth Graham

  • Senior Lecturer (Institute of Cardiovascular and Medical Sciences)
  • Associate - Life Sciences (School of Life Sciences)

telephone: 01413302524
email: Delyth.Graham@glasgow.ac.uk

Research interests

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Vaso-protective properties of maternal high density lipoprotein (HDL) in metabolic complications of pregnancy
    NHS Greater Glasgow and Clyde Endowment Funds
    2018 - 2019
     
  • Refinement in pre-clinical stroke research: investigation of morbidity and mortality and development of improved post-stroke care in rodents
    American College of Laboratory
    2015 - 2016
     
  • Investigation of Osteopontin as a candidate gene for left ventricular hypertrophy
    British Heart Foundation
    2014 - 2018
     
  • SysVasc
    European Commission
    2014 - 2018
     
  • Genetic, molecular and functional dissection of a novel pathway for hypertension: Uromodulin, renal function, sodium homeostasis and blood pressure.
    British Heart Foundation
    2013 - 2017
     
  • Abnormal uterine artery remodelling in the stroke-prone spontaneously hypertensive rat.
    Glasgow Children`s Hospital Charity
    2013 - 2013
     
  • The role of AMP-activated protein kinase in adipocyte glucose transport and insulin signalling - utilising a knockout mouse model
    Diabetes UK
    2012 - 2013
     
  • The mitochondrial-targeted antioxidant, MitoQ10: a novel therapeutic agent for cardiovascular disease.
    British Heart Foundation
    2012 - 2012
     
  • Angiotensin 1-9 and angiotensin 1-7: assessment of their mechanisms of action as counter-regulatory renin angiotensin system peptides in cardiovascular disease
    British Heart Foundation
    2011 - 2015
     
  • The role of AMP-activated protein kinase in adipocyte glucose transport and insulin signalling
    Diabetes UK
    2010 - 2013
     
  • Metabolic syndrome, hyperglycemia and experimental stroke
    Scottish Executive Health Department
    2009 - 2010
     
  • Functional characteristics of the Gstm1 deficiency in the stroke prone spontaneously hypertensive rat - in vitro and in vivo studies
    British Heart Foundation
    2004 - 2007
     

Publications

List by: Type | Date

Jump to: 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2005 | 2004 | 1999 | 1998 | 1997
Number of items: 60.

2018

Divorty, N., Milligan, G. , Graham, D. and Nicklin, S. A. (2018) The orphan receptor GPR35 contributes to angiotensin II–induced hypertension and cardiac dysfunction in mice. American Journal of Hypertension, (doi:10.1093/ajh/hpy073) (PMID:29860395) (Early Online Publication)

Montezano, A. et al. (2018) NADPH oxidase 5 is a pro-contractile Nox isoform and a point of cross-talk for calcium and redox signalling- implications in vascular function. Journal of the American Heart Association, (Accepted for Publication)

Graham, D. (2018) Modelling superimposed preeclampsia using angiotensin II infusion in pregnant stroke prone spontaneously hypertensive rats. Hypertension, (Accepted for Publication)

Camargo, L. L. et al. (2018) Vascular Nox compartmentalization, protein hyperoxidation and ER stress response in hypertension. Hypertension, (Accepted for Publication)

Bailey, E., McBride, M. W., McClure, J. D., Beattie, W., Graham, D., Dominiczak, A. , Smith, C. and Wardlaw, J. (2018) Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease. Clinical Science, (doi:10.1042/CS20171572) (PMID:29632138) (Early Online Publication)

2017

Harvey, A. P., Montezano, A. C., Hood, K. Y., Lopes, R. A., Rios, F., Ceravolo, G., Graham, D. and Touyz, R. M. (2017) Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis. Life Sciences, 179, pp. 110-119. (doi:10.1016/j.lfs.2017.05.002) (PMID:28478264) (PMCID:5446265)

Koh-Tan, H.H. C., Dashti, M., Wang, T., Beattie, W., Mcclure, J., Young, B., Dominiczak, A. F. , McBride, M. W. and Graham, D. (2017) Dissecting the genetic components of a quantitative trait locus for blood pressure and renal pathology on rat chromosome 3. Journal of Hypertension, 35(2), pp. 319-329. (doi:10.1097/HJH.0000000000001155) (PMID:27755386) (PMCID:PMC5214373)

Mancini, S. J., White, A. D., Bijland, S., Rutherford, C., Graham, D., Richter, E. A., Viollet, B., Touyz, R. M. , Palmer, T. M. and Salt, I. P. (2017) Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptorassociated kinase-4 phosphorylation. Molecular and Cellular Endocrinology, 440, pp. 44-56. (doi:10.1016/j.mce.2016.11.010) (PMID:27840174) (PMCID:PMC5228585)

2016

Small, H. Y., Nosalski, R., Morgan, H., Beattie, E., Guzik, T., Graham, D. and Delles, C. (2016) The role of tumor necrosis factor-α and natural killer cells in uterine artery function and pregnancy outcome in the stroke prone spontaneously hypertensive rat. Hypertension, 68(5), pp. 1298-1307. (doi:10.1161/HYPERTENSIONAHA.116.07933) (PMID:27733586) (PMCID:PMC5058643)

Morgan, H., Small, H.Y., Beattie, E., McBride, M.W. and Graham, D. (2016) [OP.5D.02] Transcriptomic changes in early pregnancy-associated uterine artery remodelling in stroke prone spontaneously hypertensive rat. Journal of Hypertension, 34(S2), e63-e63. (doi:10.1097/01.hjh.0000491501.79443.05) (PMID:27508758)

Wan Sulaiman, W.N., Caslake, M.J., Delles, C. , Karlsson, H., Mulder, M.T., Graham, D. and Freeman, D.J. (2016) Does high-density lipoprotein protect vascular function in healthy pregnancy? Clinical Science, 130(7), pp. 491-497. (doi:10.1042/cs20150475) (PMID:26888561)

Small, H. Y., Morgan, H., Beattie, E., Griffin, S., Indahl, M., Delles, C. and Graham, D. (2016) Abnormal uterine artery remodelling in the stroke prone spontaneously hypertensive rat. Placenta, 37, pp. 34-44. (doi:10.1016/j.placenta.2015.10.022) (PMID:26612342) (PMCID:PMC4721537)

2015

Zoccarato, A. et al. (2015) Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2. Circulation Research, 117, pp. 707-719. (doi:10.1161/CIRCRESAHA.114.305892) (PMID:26243800)

Menni, C. et al. (2015) Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate. Hypertension, 66, pp. 422-429. (doi:10.1161/HYPERTENSIONAHA.115.05544) (PMID:26034203) (PMCID:PMC4490909)

Skogstrand, T., Leh, S., McClure, J., Dashti, M., Iversen, B. M., Graham, D., McBride, M. and Hultström, M. (2015) Identification of a common molecular pathway in hypertensive renal damage. Journal of Hypertension, 33(3), pp. 584-596. (doi:10.1097/HJH.0000000000000395) (PMID:25380151)

Lopez, L. M. et al. (2015) Genes from a translational analysis support a multifactorial nature of white matter hyperintensities. Stroke, 46(2), pp. 341-347. (doi:10.1161/STROKEAHA.114.007649) (PMID:25586835) (PMCID:PMC4306534)

2014

Lee, K. M., Danuser, R., Stein, J. V., Graham, D., Nibbs, R. J.B. and Graham, G. J. (2014) The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density. EMBO Journal, 33(21), pp. 2564-2580. (doi:10.15252/embj.201488887)

Sampson, A. K., Mohammed, D., Beattie, W., Graham, D., Kenyon, C. J., Al-Dujaili, E. A.S., Guryev, V., McBride, M. W. and Dominiczak, A. F. (2014) Introgressed chromosome 2 quantitative trait loci restores aldosterone regulation and reduces response to salt in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 32(10), pp. 2013-2021. (doi:10.1097/HJH.0000000000000300)

Graham, L. A. et al. (2014) Validation of uromodulin as a candidate gene for human essential hypertension. Hypertension, 63(3), pp. 551-558. (doi:10.1161/HYPERTENSIONAHA.113.01423)

McLachlan, J., Beattie, E., Murphy, M. P., Koh-Tan, C. H.H., Olson, E., Beattie, W., Dominiczak, A. F. , Nicklin, S. A. and Graham, D. (2014) Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function. Journal of Hypertension, 32(3), pp. 555-564. (doi:10.1097/HJH.0000000000000054)

Bailey, E. L., McBride, M. W., Crawford, W., McClure, J. D., Graham, D., Dominiczak, A. F. , Sudlow, C. L.M., Smith, C. and Wardlaw, J. M. (2014) Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke. Neuropathology and Applied Neurobiology, 40(7), pp. 855-872. (doi:10.1111/nan.12116)

Baud, A. et al. (2014) Genomes and phenomes of a population of outbred rats and its progenitors. Scientific Data, 1, 140011. (doi:10.1038/sdata.2014.11) (PMID:25977769) (PMCID:PMC4381735)

Padmanabhan, S. , Graham, L., Ferreri, N. R., Graham, D., McBride, M. and Dominiczak, A. (2014) Uromodulin, an emerging novel pathway for blood pressure regulation and hypertension. Hypertension, 64(5), pp. 918-923. (doi:10.1161/HYPERTENSIONAHA.114.03132)

Sampson, A. K., Andrews, K. L., Graham, D., McBride, M. W., Head, G. A., Thomas, M. C., Chin-Dusting, J. P.F., Dominiczak, A. F. and Jennings, G. L. (2014) Origin of the y chromosome influences intrarenal vascular responsiveness to angiotensin i and angiotensin (1-7) in stroke-prone spontaneously hypertensive rats. Hypertension, 64(6), pp. 1376-1383. (doi:10.1161/HYPERTENSIONAHA.114.03756)

2013

Montezano, A. C., Yusuf, H., Graham, D. and Touyz, R. M. (2013) Redox-sensitive osteogenic factors as novel mediators of vascular injury in hypertension. Hypertension, 62(3 Sup), A490.

Baud, A. et al. (2013) Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nature Genetics, 45(7), pp. 767-775. (doi:10.1038/ng.2644)

Brittain, J.F. et al. (2013) An MRI-histological study of white matter in stroke-free SHRSP. Journal of Cerebral Blood Flow and Metabolism, 33(5), pp. 760-763. (doi:10.1038/jcbfm.2013.14)

Koh-Tan, H.H. C., McBride, M. W., McClure, J. D., Beattie, E., Young, B., Dominiczak, A. F. and Graham, D. (2013) Interaction between chromosome 2 and 3 regulates pulse pressure in the stroke-prone spontaneously hypertensive rat. Hypertension, 62(1), pp. 33-40. (doi:10.1161/HYPERTENSIONAHA.111.00814)

Tarr, D., Graham, D., Roy, L.A., Holmes, W.M., McCabe, C. , Macrae, I.M., Muir, K.W. and Dewar, D. (2013) Hyperglycemia accelerates apparent diffusion coefficient-defined lesion growth after focal cerebral ischemia in rats with and without features of metabolic syndrome. Journal of Cerebral Blood Flow and Metabolism, 33(10), pp. 1556-1563. (doi:10.1038/jcbfm.2013.107)

2012

Reid, E., Graham, D., Lopez-Gonzalez, M. R., Holmes, W. M., Macrae, I. M. and McCabe, C. (2012) Penumbra detection using PWI/DWI mismatch MRI in a rat stroke model with and without comorbidity: comparison of methods. Journal of Cerebral Blood Flow and Metabolism, 32(9), pp. 1765-1777. (doi:10.1038/jcbfm.2012.69) (PMID:22669479) (PMCID:PMC3434632)

Flores, M., Graham, D., Dominiczak, A.F. , Milligan, G. , Baker, A.H. and Nicklin, S.A. (2012) Angiotensin-(1-9) antagonises Angiotensin II-induced cardiac remodeling via the angiotensin type 2 receptor. Proceedings of the Physiological Society, 27, C1.

Flores, M., Work, L.M. , Douglas, K., Denby, L., Dominiczak, A.F. , Graham, D. and Nicklin, S.A. (2012) Angiotensin-(1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor. Hypertension, 59(2), pp. 300-307. (doi:10.1161/HYPERTENSIONAHA.111.177485)

Flores, M., Graham, D., Dominiczak, A. F. , Milligan, G. , Baker, A. H. and Nicklin, S. A. (2012) Abstract 231: angiotensin-(1-9) antagonises cardiac remodelling in a mouse model of Angiotensin Ii-induced hypertension. Hypertension, 60, A231.

Xu, H. et al. (2012) Upregulation of junctional adhesion molecule-A is a putative prognostic marker of hypertension. Cardiovascular Research, 96(3), pp. 552-560. (doi:10.1093/cvr/cvs273)

2011

Bailey, E.L., Wardlaw, J.M., Graham, D., Dominiczak, A.F. , Sudlow, C.L.M. and Smith, C. (2011) Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats. Neuropathology and Applied Neurobiology, 37(7), pp. 711-726. (doi:10.1111/j.1365-2990.2011.01170.x)

Yogi, A., Callera, G.E., Aranha, A.B., Antunes, T.T., Graham, D., McBride, M., Dominiczak, A. and Touyz, R.M. (2011) Sphingosine-1-Phosphate-Induced Inflammation Involves Receptor Tyrosine Kinase Transactivation in Vascular Cells: Upregulation in Hypertension. Hypertension, 57(4), pp. 809-818. (doi:10.1161/HYPERTENSIONAHA.110.162719)

2010

Greig, J.A., Shirley, R., Graham, D., Denby, L., Dominiczak, A.F. , Work, L.M. and Baker, A. (2010) Vascular-targeting anti-oxidant therapy in a model of hypertension and stroke. Journal of Cardiovascular Pharmacology, 56(6), pp. 642-650. (doi:10.1097/FJC.0b013e3181f8f19f)

Hopcroft, L. E.M., McBride, M. W., Harris, K. J., Sampson, A. K., McClure, J. D., Graham, D., Young, G., Holyoake, T. L., Girolami, M. A. and Dominiczak, A. F. (2010) Predictive response-relevant clustering of expression data provides insights into disease processes. Nucleic Acids Research, 38(20), pp. 6831-6840. (doi:10.1093/nar/gkq550)

Delles, C. , McBride, M.W., Graham, D., Padmanabhan, S. and Dominiczak, A.F. (2010) Genetics of hypertension: from experimental animals to humans. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1802(12), pp. 1299-1308. (doi:10.1016/j.bbadis.2009.12.006)

Graham, D., Koh-Tan, H. H. C. and Dominiczak, A. F. (2010) Reduced renal glutathione S-transferase mu type 1 expression in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 28(3), p. 634. (doi:10.1097/HJH.0b013e328336902d)

McBride, M., Hopcroft, L., Harris, K., McClure, J., Graham, D., Girolami, M. and Dominiczak, M. (2010) Insights into Salt-Sensitive Hypertension Using Response-Relevant Clustering. In: 20th Annual Meeting of the European Society of Hypertension, Oslo, Norway, 18-21 June, E342-E342.

McCabe, C. , Gallagher, L., Macrae, I.M., Gsell, W., Graham, D. and Dominiczak, A.F. (2010) Response to letter by Yao (Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats). Stroke, 41(4), E198-E199. (doi:10.1161/STROKEAHA.109.575704)

Padmanabhan, S. et al. (2010) Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genetics, 6(10), e1001177. (doi:10.1371/journal.pgen.1001177)

2009

McCabe, C. , Gallagher, L., Gsell, W., Graham, D., Dominiczak, A. F. and Macrae, I. M. (2009) Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats. Stroke, 40(12), pp. 3864-3868. (doi:10.1161/STROKEAHA.109.559021)

Graham, D., Huynh, N.N., Hamilton, C.A., Beattie, E.C., Smith, R.A.J., Cocheme, H.M., Murphy, M.P. and Dominiczak, A.F. (2009) Mitochondria-targeted antioxidant MitoQ(10) improves endothelial function and attenuates cardiac hypertrophy. Hypertension, 54(2), 322-U233. (doi:10.1161/HYPERTENSIONAHA.109.130351)

Johannesson, M. et al. (2009) A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: The NIH heterogeneous stock. Genome Research, 19(1), pp. 150-158. (doi:10.1101/gr.081497.108)

Koh-Tan, H., Graham, D., Hamilton, C., Nicoll, G., Fields, L., McBride, M., Young, B., Young, B. and Dominiczak, A. (2009) Renal and vascular glutathione S-transferase mu is not affected by pharmacological intervention to reduce systolic blood pressure. Journal of Hypertension, 27(8), pp. 1575-1584. (doi:10.1097/HJH.0b013e32832cc5a1)

Masson, R. et al. (2009) Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2. Hypertension, 53(4), pp. 694-700. (doi:10.1161/HYPERTENSIONAHA.108.122333)

Xu, A., Chamberlain, J., Francis, S., Brookes, Z., Shaw, G., Graham, D., Alp, N.J., Dower, S. and Crossman, D.C. (2009) Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding. PLoS ONE, 4(4), e5073. (doi:10.1371/journal.pone.0005073)

2008

Miller, W., Graham, D., Douglas, K., MacKenzie, R. and Dominiczak, A. (2008) Metabolic phenotypes in SHRSP and chromosome 2 congenic strains. Journal of Human Hypertension, 22(10), pp. 736-737.

Miller, W., Graham, D., Douglas, K., Mackenzie, R., Huynh, N. and Dominiczak, A. (2008) Characterisation of metabolic phenotypes in the SHRSP using chromosome 2 congenic strains. Journal of Hypertension, 26(Suppl.), S340-S341.

Tian, T., McBride, M.W., Graham, D., Touyz, R. and Dominiczak, A.F. (2008) A systems biology approach for the sphingosine-1-phosphate signal transduction in vascular smooth muscle cell. Journal of Hypertension, 26(Suppl.), S148-S148.

Tonyz, R., Aranha, A., Yogi, A., Graham, D., McBride, M., Callera, G., Montezano, A., Coimbra, T. and Dominiczak, A. (2008) Increased vascular sphingosine-1-phosphate signaling in SHRSP is due to post-receptor mechanisms. Journal of Hypertension, 26(Suppl.), S329-S329.

2007

Graham, D. et al. (2007) Candidate genes that determine response to salt in the stroke-prone spontaneously hypertensive rat - Congenic analysis. Hypertension, 50(6), pp. 1134-1141. (doi:10.1161/HYPERTENSIONAHA.107.095349)

2005

Dominiczak, A. F. , Graham, D., McBride, M. W., Brain, N. J.R., Lee, W. K., Charchar, F. J., Tomaszewski, M., Delles, C. and Hamilton, C. A. (2005) Corcoran Lecture. Cardiovascular genomics and oxidative stress. Hypertension, 45(4), pp. 636-642. (doi:10.1161/01.HYP.0000154253.53134.09)

2004

McBride, M.W., Charchar, F.J., Graham, D., Miller, W.H., Strahorn, P., Carr, F.J. and Dominiczak, A.F. (2004) Functional genomics in rodent models of hypertension. Journal of Physiology, 554(1), pp. 56-63. (doi:10.1113/jphysiol.2003.049361)

Denby, L., Work, L.M. , Graham, D., Hsu, C., Von Seggern, D.J., Nicklin, S.A. and Baker, A.H. (2004) Adenoviral serotype 5 vectors pseudotyped with fibers from subgroup D show modified tropism in vitro and in vivo. Human Gene Therapy, 15(11), pp. 1054-1064.

1999

Anderson, N. H., Devlin, A. M., Graham, D., Morton, J. J., Hamilton, C. A., Reid, J. L., Schork, N. J. and Dominiczak, A. F. (1999) Telemetry for cardiovascular monitoring in a pharmacological study: new approaches to data analysis. Hypertension, 33(1), pp. 248-255. (doi:10.1161/01.HYP.33.1.248) (PMID:9931112)

1998

Devlin, A. M., Brosnan, M. J., Graham, D., Morton, J. J., McPhaden, A. R., McIntyre, M., Hamilton, C. A., Reid, J. L. and Dominiczak, A. F. (1998) Vascular smooth muscle cell polyploidy and cardiomyocyte hypertrophy due to chronic NOS inhibition in vivo. American Journal of Physiology: Heart and Circulatory Physiology, 274(1), H52-H59. (PMID:9458851)

1997

Dominiczak, A. F. , Devlin, A. M., Brosnan, M. J., Anderson, N. H., Graham, D., Clark, J. S., McPhaden, A., Hamilton, C. A. and Reid, J. L. (1997) Left ventricular hypertrophy and arterial blood pressure in experimental models of hypertension. Advances in Experimental Medicine and Biology, 432, pp. 23-33. (doi:10.1007/978-1-4615-5385-4_3) (PMID:9433508)

This list was generated on Sun Jun 17 15:16:38 2018 BST.
Number of items: 60.

Articles

Divorty, N., Milligan, G. , Graham, D. and Nicklin, S. A. (2018) The orphan receptor GPR35 contributes to angiotensin II–induced hypertension and cardiac dysfunction in mice. American Journal of Hypertension, (doi:10.1093/ajh/hpy073) (PMID:29860395) (Early Online Publication)

Montezano, A. et al. (2018) NADPH oxidase 5 is a pro-contractile Nox isoform and a point of cross-talk for calcium and redox signalling- implications in vascular function. Journal of the American Heart Association, (Accepted for Publication)

Graham, D. (2018) Modelling superimposed preeclampsia using angiotensin II infusion in pregnant stroke prone spontaneously hypertensive rats. Hypertension, (Accepted for Publication)

Camargo, L. L. et al. (2018) Vascular Nox compartmentalization, protein hyperoxidation and ER stress response in hypertension. Hypertension, (Accepted for Publication)

Bailey, E., McBride, M. W., McClure, J. D., Beattie, W., Graham, D., Dominiczak, A. , Smith, C. and Wardlaw, J. (2018) Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease. Clinical Science, (doi:10.1042/CS20171572) (PMID:29632138) (Early Online Publication)

Harvey, A. P., Montezano, A. C., Hood, K. Y., Lopes, R. A., Rios, F., Ceravolo, G., Graham, D. and Touyz, R. M. (2017) Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis. Life Sciences, 179, pp. 110-119. (doi:10.1016/j.lfs.2017.05.002) (PMID:28478264) (PMCID:5446265)

Koh-Tan, H.H. C., Dashti, M., Wang, T., Beattie, W., Mcclure, J., Young, B., Dominiczak, A. F. , McBride, M. W. and Graham, D. (2017) Dissecting the genetic components of a quantitative trait locus for blood pressure and renal pathology on rat chromosome 3. Journal of Hypertension, 35(2), pp. 319-329. (doi:10.1097/HJH.0000000000001155) (PMID:27755386) (PMCID:PMC5214373)

Mancini, S. J., White, A. D., Bijland, S., Rutherford, C., Graham, D., Richter, E. A., Viollet, B., Touyz, R. M. , Palmer, T. M. and Salt, I. P. (2017) Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptorassociated kinase-4 phosphorylation. Molecular and Cellular Endocrinology, 440, pp. 44-56. (doi:10.1016/j.mce.2016.11.010) (PMID:27840174) (PMCID:PMC5228585)

Small, H. Y., Nosalski, R., Morgan, H., Beattie, E., Guzik, T., Graham, D. and Delles, C. (2016) The role of tumor necrosis factor-α and natural killer cells in uterine artery function and pregnancy outcome in the stroke prone spontaneously hypertensive rat. Hypertension, 68(5), pp. 1298-1307. (doi:10.1161/HYPERTENSIONAHA.116.07933) (PMID:27733586) (PMCID:PMC5058643)

Morgan, H., Small, H.Y., Beattie, E., McBride, M.W. and Graham, D. (2016) [OP.5D.02] Transcriptomic changes in early pregnancy-associated uterine artery remodelling in stroke prone spontaneously hypertensive rat. Journal of Hypertension, 34(S2), e63-e63. (doi:10.1097/01.hjh.0000491501.79443.05) (PMID:27508758)

Wan Sulaiman, W.N., Caslake, M.J., Delles, C. , Karlsson, H., Mulder, M.T., Graham, D. and Freeman, D.J. (2016) Does high-density lipoprotein protect vascular function in healthy pregnancy? Clinical Science, 130(7), pp. 491-497. (doi:10.1042/cs20150475) (PMID:26888561)

Small, H. Y., Morgan, H., Beattie, E., Griffin, S., Indahl, M., Delles, C. and Graham, D. (2016) Abnormal uterine artery remodelling in the stroke prone spontaneously hypertensive rat. Placenta, 37, pp. 34-44. (doi:10.1016/j.placenta.2015.10.022) (PMID:26612342) (PMCID:PMC4721537)

Zoccarato, A. et al. (2015) Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2. Circulation Research, 117, pp. 707-719. (doi:10.1161/CIRCRESAHA.114.305892) (PMID:26243800)

Menni, C. et al. (2015) Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate. Hypertension, 66, pp. 422-429. (doi:10.1161/HYPERTENSIONAHA.115.05544) (PMID:26034203) (PMCID:PMC4490909)

Skogstrand, T., Leh, S., McClure, J., Dashti, M., Iversen, B. M., Graham, D., McBride, M. and Hultström, M. (2015) Identification of a common molecular pathway in hypertensive renal damage. Journal of Hypertension, 33(3), pp. 584-596. (doi:10.1097/HJH.0000000000000395) (PMID:25380151)

Lopez, L. M. et al. (2015) Genes from a translational analysis support a multifactorial nature of white matter hyperintensities. Stroke, 46(2), pp. 341-347. (doi:10.1161/STROKEAHA.114.007649) (PMID:25586835) (PMCID:PMC4306534)

Lee, K. M., Danuser, R., Stein, J. V., Graham, D., Nibbs, R. J.B. and Graham, G. J. (2014) The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density. EMBO Journal, 33(21), pp. 2564-2580. (doi:10.15252/embj.201488887)

Sampson, A. K., Mohammed, D., Beattie, W., Graham, D., Kenyon, C. J., Al-Dujaili, E. A.S., Guryev, V., McBride, M. W. and Dominiczak, A. F. (2014) Introgressed chromosome 2 quantitative trait loci restores aldosterone regulation and reduces response to salt in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 32(10), pp. 2013-2021. (doi:10.1097/HJH.0000000000000300)

Graham, L. A. et al. (2014) Validation of uromodulin as a candidate gene for human essential hypertension. Hypertension, 63(3), pp. 551-558. (doi:10.1161/HYPERTENSIONAHA.113.01423)

McLachlan, J., Beattie, E., Murphy, M. P., Koh-Tan, C. H.H., Olson, E., Beattie, W., Dominiczak, A. F. , Nicklin, S. A. and Graham, D. (2014) Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function. Journal of Hypertension, 32(3), pp. 555-564. (doi:10.1097/HJH.0000000000000054)

Bailey, E. L., McBride, M. W., Crawford, W., McClure, J. D., Graham, D., Dominiczak, A. F. , Sudlow, C. L.M., Smith, C. and Wardlaw, J. M. (2014) Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke. Neuropathology and Applied Neurobiology, 40(7), pp. 855-872. (doi:10.1111/nan.12116)

Baud, A. et al. (2014) Genomes and phenomes of a population of outbred rats and its progenitors. Scientific Data, 1, 140011. (doi:10.1038/sdata.2014.11) (PMID:25977769) (PMCID:PMC4381735)

Padmanabhan, S. , Graham, L., Ferreri, N. R., Graham, D., McBride, M. and Dominiczak, A. (2014) Uromodulin, an emerging novel pathway for blood pressure regulation and hypertension. Hypertension, 64(5), pp. 918-923. (doi:10.1161/HYPERTENSIONAHA.114.03132)

Sampson, A. K., Andrews, K. L., Graham, D., McBride, M. W., Head, G. A., Thomas, M. C., Chin-Dusting, J. P.F., Dominiczak, A. F. and Jennings, G. L. (2014) Origin of the y chromosome influences intrarenal vascular responsiveness to angiotensin i and angiotensin (1-7) in stroke-prone spontaneously hypertensive rats. Hypertension, 64(6), pp. 1376-1383. (doi:10.1161/HYPERTENSIONAHA.114.03756)

Montezano, A. C., Yusuf, H., Graham, D. and Touyz, R. M. (2013) Redox-sensitive osteogenic factors as novel mediators of vascular injury in hypertension. Hypertension, 62(3 Sup), A490.

Baud, A. et al. (2013) Combined sequence-based and genetic mapping analysis of complex traits in outbred rats. Nature Genetics, 45(7), pp. 767-775. (doi:10.1038/ng.2644)

Brittain, J.F. et al. (2013) An MRI-histological study of white matter in stroke-free SHRSP. Journal of Cerebral Blood Flow and Metabolism, 33(5), pp. 760-763. (doi:10.1038/jcbfm.2013.14)

Koh-Tan, H.H. C., McBride, M. W., McClure, J. D., Beattie, E., Young, B., Dominiczak, A. F. and Graham, D. (2013) Interaction between chromosome 2 and 3 regulates pulse pressure in the stroke-prone spontaneously hypertensive rat. Hypertension, 62(1), pp. 33-40. (doi:10.1161/HYPERTENSIONAHA.111.00814)

Tarr, D., Graham, D., Roy, L.A., Holmes, W.M., McCabe, C. , Macrae, I.M., Muir, K.W. and Dewar, D. (2013) Hyperglycemia accelerates apparent diffusion coefficient-defined lesion growth after focal cerebral ischemia in rats with and without features of metabolic syndrome. Journal of Cerebral Blood Flow and Metabolism, 33(10), pp. 1556-1563. (doi:10.1038/jcbfm.2013.107)

Reid, E., Graham, D., Lopez-Gonzalez, M. R., Holmes, W. M., Macrae, I. M. and McCabe, C. (2012) Penumbra detection using PWI/DWI mismatch MRI in a rat stroke model with and without comorbidity: comparison of methods. Journal of Cerebral Blood Flow and Metabolism, 32(9), pp. 1765-1777. (doi:10.1038/jcbfm.2012.69) (PMID:22669479) (PMCID:PMC3434632)

Flores, M., Graham, D., Dominiczak, A.F. , Milligan, G. , Baker, A.H. and Nicklin, S.A. (2012) Angiotensin-(1-9) antagonises Angiotensin II-induced cardiac remodeling via the angiotensin type 2 receptor. Proceedings of the Physiological Society, 27, C1.

Flores, M., Work, L.M. , Douglas, K., Denby, L., Dominiczak, A.F. , Graham, D. and Nicklin, S.A. (2012) Angiotensin-(1-9) attenuates cardiac fibrosis in the stroke-prone spontaneously hypertensive rat via the angiotensin type 2 receptor. Hypertension, 59(2), pp. 300-307. (doi:10.1161/HYPERTENSIONAHA.111.177485)

Flores, M., Graham, D., Dominiczak, A. F. , Milligan, G. , Baker, A. H. and Nicklin, S. A. (2012) Abstract 231: angiotensin-(1-9) antagonises cardiac remodelling in a mouse model of Angiotensin Ii-induced hypertension. Hypertension, 60, A231.

Xu, H. et al. (2012) Upregulation of junctional adhesion molecule-A is a putative prognostic marker of hypertension. Cardiovascular Research, 96(3), pp. 552-560. (doi:10.1093/cvr/cvs273)

Bailey, E.L., Wardlaw, J.M., Graham, D., Dominiczak, A.F. , Sudlow, C.L.M. and Smith, C. (2011) Cerebral small vessel endothelial structural changes predate hypertension in stroke-prone spontaneously hypertensive rats: a blinded, controlled immunohistochemical study of 5- to 21-week-old rats. Neuropathology and Applied Neurobiology, 37(7), pp. 711-726. (doi:10.1111/j.1365-2990.2011.01170.x)

Yogi, A., Callera, G.E., Aranha, A.B., Antunes, T.T., Graham, D., McBride, M., Dominiczak, A. and Touyz, R.M. (2011) Sphingosine-1-Phosphate-Induced Inflammation Involves Receptor Tyrosine Kinase Transactivation in Vascular Cells: Upregulation in Hypertension. Hypertension, 57(4), pp. 809-818. (doi:10.1161/HYPERTENSIONAHA.110.162719)

Greig, J.A., Shirley, R., Graham, D., Denby, L., Dominiczak, A.F. , Work, L.M. and Baker, A. (2010) Vascular-targeting anti-oxidant therapy in a model of hypertension and stroke. Journal of Cardiovascular Pharmacology, 56(6), pp. 642-650. (doi:10.1097/FJC.0b013e3181f8f19f)

Hopcroft, L. E.M., McBride, M. W., Harris, K. J., Sampson, A. K., McClure, J. D., Graham, D., Young, G., Holyoake, T. L., Girolami, M. A. and Dominiczak, A. F. (2010) Predictive response-relevant clustering of expression data provides insights into disease processes. Nucleic Acids Research, 38(20), pp. 6831-6840. (doi:10.1093/nar/gkq550)

Delles, C. , McBride, M.W., Graham, D., Padmanabhan, S. and Dominiczak, A.F. (2010) Genetics of hypertension: from experimental animals to humans. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1802(12), pp. 1299-1308. (doi:10.1016/j.bbadis.2009.12.006)

Graham, D., Koh-Tan, H. H. C. and Dominiczak, A. F. (2010) Reduced renal glutathione S-transferase mu type 1 expression in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 28(3), p. 634. (doi:10.1097/HJH.0b013e328336902d)

McCabe, C. , Gallagher, L., Macrae, I.M., Gsell, W., Graham, D. and Dominiczak, A.F. (2010) Response to letter by Yao (Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats). Stroke, 41(4), E198-E199. (doi:10.1161/STROKEAHA.109.575704)

Padmanabhan, S. et al. (2010) Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genetics, 6(10), e1001177. (doi:10.1371/journal.pgen.1001177)

McCabe, C. , Gallagher, L., Gsell, W., Graham, D., Dominiczak, A. F. and Macrae, I. M. (2009) Differences in the evolution of the ischemic penumbra in stroke-prone spontaneously hypertensive and Wistar-Kyoto rats. Stroke, 40(12), pp. 3864-3868. (doi:10.1161/STROKEAHA.109.559021)

Graham, D., Huynh, N.N., Hamilton, C.A., Beattie, E.C., Smith, R.A.J., Cocheme, H.M., Murphy, M.P. and Dominiczak, A.F. (2009) Mitochondria-targeted antioxidant MitoQ(10) improves endothelial function and attenuates cardiac hypertrophy. Hypertension, 54(2), 322-U233. (doi:10.1161/HYPERTENSIONAHA.109.130351)

Johannesson, M. et al. (2009) A resource for the simultaneous high-resolution mapping of multiple quantitative trait loci in rats: The NIH heterogeneous stock. Genome Research, 19(1), pp. 150-158. (doi:10.1101/gr.081497.108)

Koh-Tan, H., Graham, D., Hamilton, C., Nicoll, G., Fields, L., McBride, M., Young, B., Young, B. and Dominiczak, A. (2009) Renal and vascular glutathione S-transferase mu is not affected by pharmacological intervention to reduce systolic blood pressure. Journal of Hypertension, 27(8), pp. 1575-1584. (doi:10.1097/HJH.0b013e32832cc5a1)

Masson, R. et al. (2009) Onset of experimental severe cardiac fibrosis is mediated by overexpression of angiotensin-converting enzyme 2. Hypertension, 53(4), pp. 694-700. (doi:10.1161/HYPERTENSIONAHA.108.122333)

Xu, A., Chamberlain, J., Francis, S., Brookes, Z., Shaw, G., Graham, D., Alp, N.J., Dower, S. and Crossman, D.C. (2009) Interleukin-1 regulates multiple atherogenic mechanisms in response to fat feeding. PLoS ONE, 4(4), e5073. (doi:10.1371/journal.pone.0005073)

Miller, W., Graham, D., Douglas, K., MacKenzie, R. and Dominiczak, A. (2008) Metabolic phenotypes in SHRSP and chromosome 2 congenic strains. Journal of Human Hypertension, 22(10), pp. 736-737.

Miller, W., Graham, D., Douglas, K., Mackenzie, R., Huynh, N. and Dominiczak, A. (2008) Characterisation of metabolic phenotypes in the SHRSP using chromosome 2 congenic strains. Journal of Hypertension, 26(Suppl.), S340-S341.

Tian, T., McBride, M.W., Graham, D., Touyz, R. and Dominiczak, A.F. (2008) A systems biology approach for the sphingosine-1-phosphate signal transduction in vascular smooth muscle cell. Journal of Hypertension, 26(Suppl.), S148-S148.

Tonyz, R., Aranha, A., Yogi, A., Graham, D., McBride, M., Callera, G., Montezano, A., Coimbra, T. and Dominiczak, A. (2008) Increased vascular sphingosine-1-phosphate signaling in SHRSP is due to post-receptor mechanisms. Journal of Hypertension, 26(Suppl.), S329-S329.

Graham, D. et al. (2007) Candidate genes that determine response to salt in the stroke-prone spontaneously hypertensive rat - Congenic analysis. Hypertension, 50(6), pp. 1134-1141. (doi:10.1161/HYPERTENSIONAHA.107.095349)

Dominiczak, A. F. , Graham, D., McBride, M. W., Brain, N. J.R., Lee, W. K., Charchar, F. J., Tomaszewski, M., Delles, C. and Hamilton, C. A. (2005) Corcoran Lecture. Cardiovascular genomics and oxidative stress. Hypertension, 45(4), pp. 636-642. (doi:10.1161/01.HYP.0000154253.53134.09)

McBride, M.W., Charchar, F.J., Graham, D., Miller, W.H., Strahorn, P., Carr, F.J. and Dominiczak, A.F. (2004) Functional genomics in rodent models of hypertension. Journal of Physiology, 554(1), pp. 56-63. (doi:10.1113/jphysiol.2003.049361)

Denby, L., Work, L.M. , Graham, D., Hsu, C., Von Seggern, D.J., Nicklin, S.A. and Baker, A.H. (2004) Adenoviral serotype 5 vectors pseudotyped with fibers from subgroup D show modified tropism in vitro and in vivo. Human Gene Therapy, 15(11), pp. 1054-1064.

Anderson, N. H., Devlin, A. M., Graham, D., Morton, J. J., Hamilton, C. A., Reid, J. L., Schork, N. J. and Dominiczak, A. F. (1999) Telemetry for cardiovascular monitoring in a pharmacological study: new approaches to data analysis. Hypertension, 33(1), pp. 248-255. (doi:10.1161/01.HYP.33.1.248) (PMID:9931112)

Devlin, A. M., Brosnan, M. J., Graham, D., Morton, J. J., McPhaden, A. R., McIntyre, M., Hamilton, C. A., Reid, J. L. and Dominiczak, A. F. (1998) Vascular smooth muscle cell polyploidy and cardiomyocyte hypertrophy due to chronic NOS inhibition in vivo. American Journal of Physiology: Heart and Circulatory Physiology, 274(1), H52-H59. (PMID:9458851)

Dominiczak, A. F. , Devlin, A. M., Brosnan, M. J., Anderson, N. H., Graham, D., Clark, J. S., McPhaden, A., Hamilton, C. A. and Reid, J. L. (1997) Left ventricular hypertrophy and arterial blood pressure in experimental models of hypertension. Advances in Experimental Medicine and Biology, 432, pp. 23-33. (doi:10.1007/978-1-4615-5385-4_3) (PMID:9433508)

Conference Proceedings

McBride, M., Hopcroft, L., Harris, K., McClure, J., Graham, D., Girolami, M. and Dominiczak, M. (2010) Insights into Salt-Sensitive Hypertension Using Response-Relevant Clustering. In: 20th Annual Meeting of the European Society of Hypertension, Oslo, Norway, 18-21 June, E342-E342.

This list was generated on Sun Jun 17 15:16:38 2018 BST.