Cellular signalling & Mechanisms

Our aim is to understand molecular and cellular components within metabolic tissues, how they contribute to adipose tissue expansion, and the consequences of their dysfunction in metabolic diseases.




Mary, S., Conti-Ramsden, F., Boder, P., Parveen, H., Setjiadi, D., Fleminger, J., Brockbank, A., Graham, D., Bramham, K., Chappell, L. C., Delles, C. (2023) Pregnancy-associated changes in urinary uromodulin excretion in chronic hypertension Journal of Nephrology,

Gulliver, C., Baillie, G. S., Hoffmann, R. (2023) Reduced PDE4D7 in prostate cancer correlates with genomic downregulation within the upstream PDE4D coding region Future Science OA, 9, (doi: 10.2144/fsoa-2023-0064)

Parsons, E. C., Baillie, G. S., Hoffmann, R. (2023) Revisiting the roles of cAMP signalling in the progression of prostate cancer Biochemical Journal, 480, pp. 1599-1614. (doi: 10.1042/BCJ20230297)

Meyer, B. J., Cortie, C., Dekker-Nitert, M., Barrett, H. L., Freeman, D. J. (2023) Women with gestational diabetes mellitus, controlled for plasma glucose level, exhibit maternal and fetal dyslipidaemia that may warrant treatment Diabetes Research and Clinical Practice, 204, (doi: 10.1016/j.diabres.2023.110929)

Gulliver, C., Huss, S., Semjonow, A., Baillie, G. S., Hoffmann, R. (2023) Loss of PDE4D7 expression promotes androgen independence, neuroendocrine differentiation, and alterations in DNA repair: implications for therapeutic strategies British Journal of Cancer, (doi: 10.1038/s41416-023-02417-5)

Irshad, Z., Lund, J., Sillars, A., Løvsletten, N. G., Gharanei, S., Salt, I. P., Freeman, D. J., Gill, J. M.R., Thoresen, G. H., Rustan, A. C., Zammit, V. A. (2023) The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background FASEB Journal,

Wright, T. A., Gemmell, A. O., Tejeda, G. S., Blair, C. M., Baillie, G. S. (2023) Cancer: phosphodiesterase type 4C (PDE4C), the forgotten subfamily as a therapeutic target International Journal of Biochemistry and Cell Biology, 162, (doi: 10.1016/j.biocel.2023.106453)

Zorn, A., Baillie, G. (2023) Phosphodiesterase 7 as a therapeutic target – Where are we now? Cellular Signalling, 108, (doi: 10.1016/j.cellsig.2023.110689)

Olivera, S., Graham, D. (2023) Sex differences in preclinical models of hypertension Journal of Human Hypertension, 37, pp. 619-625. (doi: 10.1038/s41371-022-00770-1)

Martin, T. P., MacDonald, E. A., Bradley, A., Watson, H., Saxena, P., Rog-Zielinska, E. A., Raheem, A., Fisher, S., Elbassioni, A. A. M., Almuzaini, O., Booth, C., Campbell, M., Riddell, A., Herzyk, P., Blyth, K., Nixon, C., Zentilin, L., Berry, C., Braun, T., Giacca, M., McBride, M. W., Nicklin, S. R., Cameron, E. R., Loughrey, C. (2023) Ribonucleicacid interference or small molecule inhibition of Runx1 in the border zone prevents cardiac contractile dysfunction following myocardial infarction Cardiovascular Research, (doi: 10.1093/cvr/cvad107)

Paes, D., Schepers, M., Willems, E., Rombaut, B., Tiane, A., Solomina, Y., Tibbo, A., Blair, C., Kyurkchieva, E., Baillie, G. S., Ricciarelli, R., Brullo, C., Fedele, E., Bruno, O., van den Hove, D., Vanmierlo, T., Prickaerts, J. (2023) Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology Cellular and Molecular Life Sciences, 80, (doi: 10.1007/s00018-023-04804-w)

Dowsett, L., Duluc, L., Higgins, E., Alghamdi, F., Fast, W., Salt, I. P., Leiper, J. (2023) Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation Cellular Signalling, 107, (doi: 10.1016/j.cellsig.2023.110676)

Kyurkchieva, E., Baillie, G. S. (2023) Short PDE4 isoforms as drug targets in disease Frontiers in Bioscience: Landmark, 28, (doi: 10.31083/j.fbl2807133)

Brown, A. D., Vergunst, K. L., Branch, M., Blair, C. M., Dupré, D. J., Baillie, G. S., Langelaan, D. N. (2023) Structural basis of CBP/p300 recruitment by the microphthalmia-associated transcription factor Biochimica et Biophysica Acta: Molecular Cell Research, (doi: 10.1016/j.bbamcr.2023.119520)

Gulliver, C., Huss, S., Semjonow, A., Baillie, G. S., Hoffmann, R. (2023) The CAPRA&PDE4D5/7/9 prognostic model is significantly associated to adverse post-surgical pathology outcomes Cancers, 15, (doi: 10.3390/cancers15010262)


Gerganova, G., Riddell, A., Miller, A. A. (2022) CNS border-associated macrophages in the homeostatic and ischaemic brain Pharmacology and Therapeutics, 240, (doi: 10.1016/j.pharmthera.2022.108220)

Kumar, A. A., Yeo, N., Whittaker, M., Attra, P., Barrick, T. R., Bridges, L. R., Dickson, D. W., Esiri, M. M., Farris, C. W., Graham, D., Lin, W. L., Meijles, D. N., Pereira, A. C., Perry, G., Rosene, D. L., Shtaya, A. B., Van Agtmael, T., Zamboni, G., Hainsworth, A. H. (2022) Vascular collagen type-IV in hypertension and cerebral small vessel disease Stroke, 53, pp. 3696-3705. (doi: 10.1161/STROKEAHA.122.037761)

Mary, S., Boder, P., Padmanabhan, S., McBride, M. W., Graham, D., Delles, C., Dominiczak, A. F. (2022) The role of uromodulin in salt-sensitive hypertension Hypertension, 79, pp. 2419-2429. (doi: 10.1161/HYPERTENSIONAHA.122.19888)

Main, A., Bogusalvskyii, A., Howie, J., Kuo, C.-W., Rankin, A., Burton, F. L., Smith, G. L., Hajjar, R., Baillie, G. S., Campbell, K. S., Shattock, M. J., Fuller, W. (2022) Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies Frontiers in Physiology, 13, (doi: 10.3389/fphys.2022.1023237)

Reel, P. S., Reel, S., van Kralingen, J. C., Langton, K., Lang, K., Erlic, Z., Larsen, C. K., Amar, L., Pamporaki, C., Mulatero, P., Blanchard, A., Kabat, M., Robertson, S., MacKenzie, S. M., Taylor, A. E., Peitzsch, M., Ceccato, F., Scaroni, C., Reincke, M., Kroiss, M., Dennedy, M. C., Pecori, A., Monticone, S., Deinum, J., Rossi, G. P., Lenzini, L., McClure, J. D., Nind, T., Riddell, A., Stell, A., Cole, C., Sudano, I., Prehn, C., Adamski, J., Gimenez-Roqueplo, A.-P., Assié, G., Arlt, W., Beuschlein, F., Eisenhofer, G., Davies, E., Zennaro, M.-C., Jefferson, E. (2022) Machine learning for classification of hypertension subtypes using multi-omics: a multi-centre, retrospective, data-driven study EBioMedicine, 84, (doi: 10.1016/j.ebiom.2022.104276)

Fertig, B., Ling, J., Nollet, E. E., Dobi, S., Busiau, T., Ishikawa, K., Yamada, K., Lee, A., Kho, C., Wills, L., Tibbo, A. J., Scott, M., Grant, K., Campbell, K. S., Birks, E. J., MacQuaide, N., Hajjar, R., Smith, G. L., van der Velden, J., Baillie, G. (2022) SUMOylation does not affect cardiac troponin I stability but alters indirectly the development of force in response to Ca2+ FEBS Journal, 289, pp. 6267-6285. (doi: 10.1111/febs.16537)

McQueen, A., Escuer, J., Schmidt, A. F., Aggarwal, A., Kennedy, S., McCormick, C., Oldroyd, K., Mcginty, S. (2022) An intricate interplay between stent drug dose and release rate dictates arterial restenosis Journal of Controlled Release, 349, pp. 992-1008. (doi: 10.1016/j.jconrel.2022.07.037)

Daly, C., Briddon, S. (2022) Pharmacology in the Metaverse Pharmacology Matters, 2022,

Stathopoulou, K., Schnittger, J., Raabe, J., Fleischer, F., Mangels, N., Piasecki, A., Findlay, J., Hartmann, K., Krasemann, S., Schlossarek, S., Uebeler, J., Wixler, V., Blake, D. J., Baillie, G., Carrier, L., Ehler, E., Cuello, F. (2022) CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes FEBS Journal, 289, pp. 4622-4645. (doi: 10.1111/febs.16402)

Gulliver, C., Hoffmann, R., Baillie, G. S. (2022) Ataxia-telangiectasia mutated and ataxia telangiectasia and Rad3-related kinases as therapeutic targets and stratification indicators for prostate cancer International Journal of Biochemistry and Cell Biology, 147, (doi: 10.1016/j.biocel.2022.106230)

Fullerton, J. L., Thomas, J. M., Gonzalez-Trueba, L., Trivett, C., Van Kralingen, J. C., Allan, S. M., Quinn, T. J., Work, L. M. (2022) Systematic review: association between circulating microRNA expression & stroke Journal of Cerebral Blood Flow and Metabolism, 42, pp. 935-951. (doi: 10.1177/0271678X221085090)

Beazer, J. D., Freeman, D. J. (2022) Estradiol and HDL function in women – a partnership for life Journal of Clinical Endocrinology and Metabolism, 107, pp. e2192-2194. (doi: 10.1210/clinem/dgab811)

He, W., McCarroll, C. S., Nather, K., Ford, K., Mangion, K., Riddell, A., O'Toole, D., Zaeri, A., Corcoran, D., Carrick, D., Lee, M. M.Y., McEntegart, M., Davie, A., Good, R., Lindsay, M. M., Eteiba, H., Rocchiccioli, P., Watkins, S., Hood, S., Shaukat, A., McArthur, L., Elliott, E. B., McClure, J., Hawksby, C., Martin, T., Petrie, M. C., Oldroyd, K. G., Smith, G. L., Channon, K. M., Berry, C., Nicklin, S. A., Loughrey, C. M. (2022) Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size Cardiovascular Research, 118, pp. 1535-1547. (doi: 10.1093/cvr/cvab204)

Malfait, F., Forlino, A., Sengle, G., Van Agtmael, T. (2022) Editorial: molecular mechanisms of heritable connective tissue disorders Frontiers in Genetics, 13, (doi: 10.3389/fgene.2022.866665)

Fullerton, J. L., Cosgrove, C. C., Rooney, R. A., Work, L. (2022) Extracellular vesicles and their microRNA cargo in ischaemic stroke Journal of Physiology, (doi: 10.1113/JP282050)

Tibbo, A. J., Mika, D., Dobi, S., Ling, J., McFall, A., Tejeda, G. S., Blair, C., MacLeod, R., MacQuaide, N., Gök, C., Fuller, W., Smith, B. O., Smith, G. L., Vandecasteele, G., Brand, T., Baillie, G. S. (2022) Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins Journal of Molecular and Cellular Cardiology, 165, pp. 86-102. (doi: 10.1016/j.yjmcc.2022.01.001)

Dritsoula, A., Dowsett, L., Pilotti, C., O'Connor, M. N., Moss, S. E., Greenwood, J. (2022) Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway Scientific Reports, 12, (doi: 10.1038/s41598-022-08516-2)

Martin, T. P., MacDonald, E. A., Elbassioni, A. A., Zaeri, A. A. I., O'Toole, D., Nicklin, S. A., Gray, G. A., Loughrey, C. M. (2022) Pre-clinical models of myocardial infarction: from mechanism to translation British Journal of Pharmacology, 179, pp. 770-791. (doi: 10.1111/bph.15595)

Stoyek, M. R., MacDonald, E., Mantifel, M., Baillie, J. S., Selig, B. M., Croll, R. P., Smith, F. M., Quinn, T. A. (2022) Drivers of sinoatrial node automaticity in zebrafish: comparison with mechanisms of mammalian pacemaker function Frontiers in Physiology, 13, (doi: 10.3389/fphys.2022.818122)

Bakalchuk, S., Walker, C., Daly, C., Hill, L., Poyade, M. (2022) Creating interactive three-dimensional applications to visualise novel stent grafts that aid in the treatment of aortic aneurysms Springer

Douglass, A., Moffat, G., Daly, C. (2022) Using confocal microscopy to generate an accurate vascular model for use in patient education animation Springer

Baillie, G., Kyurkchieva, E., Sin, Y. Y., Ahmed, F., Rajapakse, N., Schoolmeesters, A., Richard, N., Erdman, P., Hecht, D., Chourasia, A. H., Mercurio, F., Fung, L., Chan, K., Stirling, D. (2022) Evaluating the Utility of Bi-functional Degrader Molecules for Selective Inhibition of PDE4 In Acrodysostosis Type2


Trivett, C., Lees, Z. J., Freeman, D. J. (2021) Adipose tissue function in healthy pregnancy, gestational diabetes mellitus and pre-eclampsia European Journal of Clinical Nutrition, 75, pp. 1745-1756. (doi: 10.1038/s41430-021-00948-9)

Omar, R., Malfait, F., Van Agtmael, T. (2021) Four decades in the making: collagen III and mechanisms of vascular Ehlers Danlos Syndrome Matrix Biology Plus, 12, (doi: 10.1016/j.mbplus.2021.100090)

Alsufyani, H. A., Daly, C., Docherty, J. R. (2021) Interaction between α 1B ‐ and other α 1 ‐ and α 2 ‐adrenoceptors in producing contractions of mouse spleen Basic and Clinical Pharmacology and Toxicology, 129, pp. 416-426. (doi: 10.1111/bcpt.13639)

Mary, S., Boder, P., Rossitto, G., Graham, L., Scott, K., Flynn, A., Kipgen, D., Graham, D., Delles, C. (2021) Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats Clinical Science, 135, pp. 2749-2761. (doi: 10.1042/CS20211017)

Mahindra, A., Tejeda, G., Rossi, M., Janha, O., Herbert, I., Morris, C., Morgan, D. C., Beattie, W., Montezano, A. C., Hudson, B., Tobin, A. B., Bhella, D., Touyz, R. M., Jamieson, A. G., Baillie, G. S., Blair, C. M. (2021) Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction PLoS ONE, 16, (doi: 10.1371/journal.pone.0260283)

O'Connor, M. N., Kallenberg, D. M., Camilli, C., Pilotti, C., Dritsoula, A., Jackstadt, R., Bowers, C. E., Watson, H. A., Alatsatianos, M., Ohme, J., Dowsett, L., George, J., Blackburn, J. W.D., Wang, X., Singhal, M., Augustin, H. G., Ager, A., Sansom, O. J., Moss, S. E., Greenwood, J. (2021) LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency Med, 2, pp. 1231-1252.e10. (doi: 10.1016/j.medj.2021.10.002)

MacKenzie, S. M., Saunders, H., van Kralingen, J. C., Robertson, S., Riddell, A., Zennaro, M.-C., Davies, E. (2021) Circulating microRNAs as diagnostic markers in primary aldosteronism Cancers, 13, (doi: 10.3390/cancers13215312)

MacDonald, E. A., Quinn, T. A. (2021) What keeps us ticking? Sinoatrial node mechano-sensitivity: the grandfather clock of cardiac rhythm Biophysical Reviews, 13, pp. 707-716. (doi: 10.1007/s12551-021-00831-8)

Pokhilko, A., Brezzo, G., Handunnetthi, L., Heilig, R., Lennon, R., Smith, C., Allan, S. M., Granata, A., Sinha, S., Wang, T., Markus, H. S., Naba, A., Fischer, R., Van Agtmael, T., Horsburgh, K., Cader, M. Z. (2021) Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease Journal of Cerebral Blood Flow and Metabolism, 41, pp. 2423-2438. (doi: 10.1177/0271678X211004307)

Buist, H. K., Luchowska-Stańska, U., van Basten, B., Valli, J., Smith, B. O., Baillie, G. S., Rickman, C., Ricketts, B., Davidson, A., Hannam, R., Sunderland, J., Yarwood, S. J. (2021) Identification and characterization of an affimer affinity reagent for the detection of the cAMP sensor, EPAC1 Cells, 10, (doi: 10.3390/cells10092307)

Alves-Lopes, R., Montezano, A. C., Neves, K. B., Harvey, A., Rios, F. J., Skiba, D. S., Arendse, L. B., Guzik, T. J., Graham, D., Poglitsch, M., Sturrock, E., Touyz, R. M. (2021) Selective inhibition of the C-domain of ACE (angiotensin-converting enzyme) combined with inhibition of NEP (neprilysin): a potential new therapy for hypertension Hypertension, 78, pp. 604-616. (doi: 10.1161/HYPERTENSIONAHA.121.17041)

Patanapirunhakit, P., Karlsson, H., Mulder, M., Ljunggren, S., Graham, D., Freeman, D. (2021) Sphingolipids in HDL – potential markers for adaptation to pregnancy? Biochimica et Biophysica Acta: Molecular and Cell Biology of Lipids, 1866, (doi: 10.1016/j.bbalip.2021.158955)

Boland, E., Quondamatteo, F., Van Agtmael, T. (2021) The role of basement membranes in cardiac biology and disease Bioscience Reports, 41, pp. BSR20204185. (doi: 10.1042/bsr20204185)

Chung, J., Hamilton, G., Kim, M., Marini, S., Montgomery, B., Henry, J., Cho, A. E., Brown, D. L., Worrall, B. B., Meschia, J. F., Silliman, S. L., Selim, M., Tirschwell, D. L., Kidwell, C. S., Kissela, B., Greenberg, S. M., Viswanathan, A., Goldstein, J. N., Langefeld, C. D., Rannikmae, K., Sudlow, C. L.M., Samarasekera, N., Rodrigues, M., Al-Shahi Salman, R., Prendergast, J. G.D., Harris, S. E., Deary, I., Woo, D., Rosand, J., Van Agtmael, T., Anderson, C. D. (2021) Rare missense functional variants at COL4A1 and COL4A2 in sporadic intracerebral hemorrhage Neurology, 97, pp. e236-e247. (doi: 10.1212/WNL.0000000000012227)

Randles, M., Lausecker, F., Kong, Q., Suleiman, H., Reid, G., Kolatsi-Joannou, M., Tian, P., Falcone, S., Davenport, B., Potter, P., Van Agtmael, T., Norman, J., Long, D., Humphries, M., Miner, J., Lennon, R. (2021) Identification of an altered matrix signature in kidney aging and disease Journal of the American Society of Nephrology, 32, pp. 1713-1732. (doi: 10.1681/ASN.2020101442)

Morgan, D. C., Morris, C., Mahindra, A., Blair, C. M., Tejeda, G., Herbert, I., Turnbull, M. L., Lieber, G., Willett, B. J., Logan, N., Smith, B., Tobin, A. B., Bhella, D., Baillie, G. S., Jamieson, A. G. (2021) Stapled ACE2 peptidomimetics designed to target the SARS-CoV-2 spike protein do not prevent virus internalisation Peptide Science, 113, (doi: 10.1002/pep2.24217)

Reuten, R., Zendehroud, S., Nicolau, M., Fleischhauer, L., Laitala, A., Kiderlen, S., Nikodemus, D., Wullkopf, L., Nielsen, S. R., McNeilly, S., Prein, C., Rafaeva, M., Schoof, E. M., Furtwängler, B., Porse, B. T., Kim, H., Won, K. J., Sudhop, S., Westarp Zornhagen, K., Suhr, F., Maniati, E., Pearce, O. M.T., Koch, M., Oddershede, L. B., Van Agtmael, T., Madsen, C. D., Mayorca Guiliani, A. E., Bloch, W., Netz, R. R., Clausen-Schaumann, H., Erler, J. T. (2021) Basement membrane stiffness determines metastases formation Nature Materials, 20, pp. 892-903. (doi: 10.1038/s41563-020-00894-0)

McQueen, A., Escuer, J., Aggarwal, A., Kennedy, S., McCormick, C., Oldroyd, K., Mcginty, S. (2021) Do we really understand how drug eluted from stents modulates arterial healing? International Journal of Pharmaceutics, 601, (doi: 10.1016/j.ijpharm.2021.120575)

Schofield, C. L., Rodrigo-Navarro, A., Dalby, M. J., Van Agtmael, T., Salmeron-Sanchez, M. (2021) Biochemical­­– and biophysical–induced barriergenesis in the blood brain barrier: a review of barriergenic factors for use in in vitro models Advanced NanoBiomed Research, 1, (doi: 10.1002/anbr.202000068)

Dean, A., Van Agtmael, T. (2021) Collagen IV-related diseases and therapies Springer

Scott, K., Morgan, H. L., Delles, C., Fisher, S., Graham, D., McBride, M. W. (2021) Distinct uterine artery gene expression profiles during early gestation in the stroke-prone spontaneously hypertensive rat Physiological Genomics, 53, pp. 160-171. (doi: 10.1152/physiolgenomics.00159.2020)

Scott, M., Blondel-Tepaz, E., Leverve, M., Sokrat, B., Paradis, J., Kosic, M., Saha, K., Auffray, C., Lima-Fernandes, E., Zamborlini, A., Poupon, A., Gaboury, L., Findlay, J., Baillie, G., Enslen, H., Bouvier, M., Angers, S., Marullo, S. (2021) The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signalling axis Oncogene, 40, pp. 2243-2257. (doi: 10.1038/s41388-021-01704-w)

Baillie, G. S., Gulliver, C., Hoffmann, R. (2021) The enigmatic helicase DHX9 and its association with the hallmarks of cancer Future Science OA, 7, (doi: 10.2144/fsoa-2020-0140)


Abdulqader, A., Kennedy, S. (2020) The influence of perivascular adipose tissue on vascular function in a rabbit model Pharmacology and Pharmacy, 11, pp. 331-349. (doi: 10.4236/pp.2020.1112027)

Zamai, N., Cortie, C. H., Jarvie, E. M., Onyiaodike, C. C., Alrehaili, A., Francois, M., Freeman, D. J., Meyer, B. J. (2020) In pregnancy, maternal HDL is specifically enriched in, and carries the highest proportion of, DHA in plasma Prostaglandins, Leukotrienes and Essential Fatty Acids, 163, (doi: 10.1016/j.plefa.2020.102209)

Main, A., Fuller, W., Baillie, G. S. (2020) Post-translational regulation of cardiac myosin binding protein-C: a graphical review Cellular Signalling, 76, (doi: 10.1016/j.cellsig.2020.109788)

Beazer, J. D., Patanapirunhakit, P., Gill, J. M.R., Graham, D., Karlsson, H., Ljunggren, S., Mulder, M., Freeman, D. J. (2020) High-density lipoprotein’s vascular protective functions in metabolic and cardiovascular disease - could extracellular vesicles be at play? Clinical Science, 134, pp. 2977-2986. (doi: 10.1042/CS20200892)

Dowsett, L., Higgins, E., Alanazi, S., Alshuwayer, N. A., Leiper, F. C., Leiper, J. (2020) ADMA: A key player in the relationship between vascular dysfunction and inflammation in atherosclerosis Journal of Clinical Medicine, 9, (doi: 10.3390/jcm9093026)

Ngandu Mpoyi, E., Cantini, M., Sin, Y. Y., Fleming, L., Zhou, D. W., Costell, M., Lu, Y., Kadler, K., García, A. J., Van Agtmael, T., Salmeron-Sanchez, M. (2020) Material-driven fibronectin assembly rescues matrix defects due to mutations in collagen IV in fibroblasts Biomaterials, 252, (doi: 10.1016/j.biomaterials.2020.120090)

Rossitto, G., Mary, S., Chen, J. Y., Bodder, P., Chew, K. S., Neves, K. B., Alves, R. L., Montezano, A. C., Welsh, P., Petrie, M. C., Graham, D., Touyz, R. M., Delles, C. (2020) Tissue sodium excess is not hypertonic and reflects extracellular volume expansion Nature Communications, 11, (doi: 10.1038/s41467-020-17820-2)

Zou, Z.-G., Rios, F. J., Neves, K. B., Alves-Lopes, R., Ling, J., Baillie, G. S., Gao, X., Fuller, W., Camargo, L. L., Gudermann, T., Chubanov, V., Montezano, A. C., Touyz, R. M. (2020) Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function Clinical Science, 134, pp. 2019-2035. (doi: 10.1042/CS20200827)

MacDonald, E. A., Madl, J., Greiner, J., Ramadan, A. F., Wells, S. M., Torrente, A. G., Kohl, P., Rog-Zielinska, E. A., Quinn, T. A. (2020) Sinoatrial node structure, mechanics, electrophysiology and the chronotropic response to stretch in rabbit and mouse Frontiers in Physiology, 11, (doi: 10.3389/fphys.2020.00809)

Riddell, A., McBride, M., Braun, T., Nicklin, S. A., Cameron, E., Loughrey, C. M., Martin, T. P. (2020) RUNX1: an emerging therapeutic target for cardiovascular disease Cardiovascular Research, 116, pp. 1410-1423. (doi: 10.1093/cvr/cvaa034)

Williams, J. J.L., Baillie, G. S., Palmer, T. M. (2020) Investigation of Novel Cavin-1/Suppressor of Cytokine Signaling 3 (SOCS3) Interactions by Coimmunoprecipitation, Peptide Pull-Down, and Peptide Array Overlay Approaches Springer

Gök, C., Plain, F., Robertson, A., Howie, J., Baillie, G. S., Fraser, N. J., Fuller, W. (2020) Dynamic palmitoylation of the sodium-calcium exchanger modulates its structure, affinity for lipid ordered domains, and inhibition by XIP Cell Reports, 31, (doi: 10.1016/j.celrep.2020.107697)

Ling, J., Blair, C. M., Baillie, G. S. (2020) Fibrin Breakdown Assay Bio-Protocol, 10, (doi: 10.21769/BioProtoc.3585)

Nosalski, R., Siedlinski, M., Denby, L., Mcginnigle, E., Nowak, M., Nguyen Dinh Cat, A., Medina-Ruiz, L., Cantini, M., Skiba, D., Wilk, G., Osmenda, G., Rodor, J., Salmeron-Sanchez, M., Graham, G., Maffia, P., Graham, D., Baker, A. H., Guzik, T. J. (2020) T cell-derived miRNA-214 mediates perivascular fibrosis in hypertension Circulation Research, 126, pp. 988-1003. (doi: 10.1161/CIRCRESAHA.119.315428)

Blair, C. M., Ling, J., Baillie, G. S. (2020) Measuring cAMP specific phosphodiesterase activity: a two-step radioassay Bio-Protocol, 10, (doi: 10.21769/BioProtoc.3581)

Frazier, S., McBride, M. W., Mulvana, H., Graham, D. (2020) From animal models to patients: the role of placental microRNAs, miR-210, miR-126, and miR-148a/152 in preeclampsia Clinical Science, 134, pp. 1001-1025. (doi: 10.1042/CS20200023)

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Daly, C. J. (2019) Imaging the vascular wall: from microscope to virtual reality Springer

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Blair, C. M., Walsh, N., Littman, B. H., Marcoux, F. W., Baillie, G. S. (2019) Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A – C-Raf BMC Cancer, 19, (doi: 10.1186/s12885-019-5489-4)

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Strembitska, A., Mancini, S. J., Gamwell, J. M., Palmer, T. M., Baillie, G. S., Salt, I. P. (2018) A769662 inhibits insulin-stimulated Akt activation in human macrovascular endothelial cells independent of AMP-activated protein kinase International Journal of Molecular Sciences, 19, (doi: 10.3390/ijms19123886)

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Armfield, K., Baillie, G., Wilson, J.B. (2018) Development of Therapeutic Approaches to Targeting Epstein-Barr virus Related Malignancies

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Fertig, B. A., Baillie, G. S. (2018) PDE4-mediated cAMP signalling Journal of Cardiovascular Development and Disease, 5, (doi: 10.3390/jcdd5010008)

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Rodrigues, A. L., Brescia, M., Kolshinski, A., Moreira, T. H., Cameron, R. T., Baillie, G., Beirão, P. S.L., Zaccollo, M., Cruz, J. S. (2018) Increase in Ca2+ current by sustained cAMP levels enhances proliferation rate in GH3 cells Life Sciences, 192, pp. 144-150. (doi: 10.1016/j.lfs.2017.11.040)

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Lemonidis, K., MacLeod, R., Baillie, G. S., Chamberlain, L. H. (2017) Peptide array based screening reveals a large number of proteins interacting with the ankyrin repeat domain of the zDHHC17 S-acyltransferase Journal of Biological Chemistry, 292, pp. 17190-17202. (doi: 10.1074/jbc.M117.799650)

Almabrouk, T. A. M., Ugusman, A. B., Katwan, O. J., Salt, I. P., Kennedy, S. (2017) Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adiponectin release British Journal of Pharmacology, 174, pp. 3398-3410. (doi: 10.1111/bph.13633)

Kennedy, S., Salt, I. P. (2017) Molecular mechanisms regulating perivascular adipose tissue - potential pharmacological targets? British Journal of Pharmacology, 174, pp. 3385-3387. (doi: 10.1111/bph.13969)

Jayabalan, N., Nair, S., Nuzhat, Z., Rice, G. E., Zúñiga, F. A., Sobrevia, L., Leiva, A., Sanhueza, C., Agustin Gutierrez, J., Lappas, M., Freeman, D. J., Salomon, C. (2017) Cross talk between adipose tissue and placenta in obese and gestational diabetes mellitus pregnancies via exosomes Frontiers in Endocrinology, 8, (doi: 10.3389/fendo.2017.00239)

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Gao, X., Salomon, C., Freeman, D. J. (2017) Extracellular vesicles from adipose tissue - a potential role in obesity and type 2 diabetes? Frontiers in Endocrinology, 8, (doi: 10.3389/fendo.2017.00202)

Patil, K. C., Daly, C. J. (2017) Nanotechnology-based α1-adrenoceptor/gpr55 biomarker assay: molecular prognostic test for aggressive prostate cancer on the horizon? Socrates Almanac, 2017, pp. 20-22.

Nishi, K., Luo, H., Ishikura, S., Doi, K., Iwaihara, Y., Wills, L., Baillie, G. S., Sakata, T., Shirasawa, S., Tsunoda, T. (2017) Apremilast induces apoptosis of human colorectal cancer cells with mutant KRAS Anticancer Research, 37, pp. 3833-3839. (doi: 10.21873/anticanres.11762)

Kiely, M., Adams, D. R., Hayes, S. L., O'Connor, R., Baillie, G. S., Kiely, P. A. (2017) RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells Cellular Signalling, 35, pp. 290-300. (doi: 10.1016/j.cellsig.2016.09.001)

Abu Bakar, H., Dunn, W. R., Daly, C., Ralevic, V. (2017) Sensory innervation of perivascular adipose tissue: a crucial role in artery vasodilatation and leptin release Cardiovascular Research, 113, pp. 962-972. (doi: 10.1093/cvr/cvx062)

Wang, D., Mohammad, M., Wang, Y., Tan, R., Murray, L. S., Ricardo, S., Dagher, H., van Agtmael, T., Savige, J. (2017) The chemical chaperone, PBA, reduces ER stress and autophagy and increases collagen IV α5 expression in cultured fibroblasts from men with X-linked Alport syndrome and missense mutations Kidney International Reports, 2, pp. 739-748. (doi: 10.1016/j.ekir.2017.03.004)

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Harvey, A. P., Montezano, A. C., Hood, K. Y., Lopes, R. A., Rios, F., Ceravolo, G., Graham, D., Touyz, R. M. (2017) Vascular dysfunction and fibrosis in stroke-prone spontaneously hypertensive rats: the aldosterone-mineralocorticoid receptor-Nox1 Axis Life Sciences, 179, pp. 110-119. (doi: 10.1016/j.lfs.2017.05.002)

Ibáñez de Opakua, A., Parag-Sharma, K., DiGiacomo, V., Merino, N., Leyme, A., Marivin, A., Villate, M., Nguyen, L. T., de la Cruz-Morcillo, M. A., Blanco-Canosa, J. B., Ramachandran, S., Baillie, G. S., Cerione, R. A., Blanco, F. J., Garcia-Marcos, M. (2017) Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif Nature Communications, 8, (doi: 10.1038/ncomms15163)

Diamantopoulou, Z., White, G., Fadlullah, M. Z.H., Dreger, M., Pickering, K., Maltas, J., Ashton, G., MacLeod, R., Baillie, G. S., Kouskoff, V., Lacaud, G., Murray, G. I., Sansom, O. J., Hurlstone, A. F.L., Malliri, A. (2017) TIAM1 antagonizes TAZ/YAP both in the destruction complex in the cytoplasm and in the nucleus to inhibit invasion of intestinal epithelial cells Cancer Cell, 31, pp. 621-634. (doi: 10.1016/j.ccell.2017.03.007)

Monterisi, S., Lobo, M. J., Livie, C., Castle, J. C., Weinberger, M., Baillie, G., Surdo, N. C., Musheshe, N., Stangherlin, A., Gottlieb, E., Maizels, R., Bortolozzi, M., Micaroni, M., Zaccolo, M. (2017) PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling eLife, 6, (doi: 10.7554/eLife.21374)

Meyer, B. J., Freeman, D. J. (2017) Maternal plasma docosahexaenoic acid (DHA) concentrations increase at the critical time of neural tube closure Fats of Life,

Schoenherr, C., Byron, A., Sandilands, E., Paliashvili, K., Baillie, G. S., Valacca, C., Cecconi, F., Serrels, B., Frame, M. C. (2017) Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks eLife, 6, (doi: 10.7554/eLife.23172)

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Houslay, K. F., Christian, F., MacLeod, R., Adams, D. R., Houslay, M. D., Baillie, G. S. (2017) Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners Biochemical Journal, 474, pp. 597-609. (doi: 10.1042/BCJ20160849)

Freeman, D. J., Meyer, B. J. (2017) Brain food for babies Biochemist, 39, pp. 26-29.

Koh-Tan, H.H. C., Dashti, M., Wang, T., Beattie, W., Mcclure, J., Young, B., Dominiczak, A. F., McBride, M. W., Graham, D. (2017) Dissecting the genetic components of a quantitative trait locus for blood pressure and renal pathology on rat chromosome 3 Journal of Hypertension, 35, pp. 319-329. (doi: 10.1097/HJH.0000000000001155)

Deschamps, T., Quentin, B., Leske, D. M., MacLeod, R., Mompelat, D., Tafforeau, L., Lotteau, V., Maréchal, V., Baillie, G. S., Gruffat, H., Wilson, J. B., Manet, E. (2017) Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle Journal of General Virology, 98, pp. 251-265. (doi: 10.1099/jgv.0.000681)

Mancini, S. J., White, A. D., Bijland, S., Rutherford, C., Graham, D., Richter, E. A., Viollet, B., Touyz, R. M., Palmer, T. M., Salt, I. P. (2017) Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptorassociated kinase-4 phosphorylation Molecular and Cellular Endocrinology, 440, pp. 44-56. (doi: 10.1016/j.mce.2016.11.010)

Cameron, R. T., Whiteley, E., Day, J. P., Parachikova, A. I., Baillie, G. S. (2017) Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1-42 mediated cytotoxicity FEBS Open Bio, 7, pp. 64-73. (doi: 10.1002/2211-5463.12156)

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Javadi, A., Deevi, R. K., Evergren, E., Blondel-Tepaz, E., Baillie, G. S., Scott, M. G.H., Campbell, F. C. (2017) PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex eLife, 6, (doi: 10.7554/eLife.24578)


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Böttcher, R., Dulla, K., van Strijp, D., Dits, N., Verhoef, E. I., Baillie, G. S., Van Leenders, G. J.L.H., Houslay, M. D., Jenster, G., Hoffmann, R. (2016) Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and development of distant metastases Oncotarget, 7, pp. 70669-70684. (doi: 10.18632/oncotarget.12204)

Yun, S., Budatha, M., Dahlman, J. E., Coon, B. G., Cameron, R. T., Langer, R., Anderson, D. G., Baillie, G., Schwartz, M. A. (2016) Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling Nature Cell Biology, 18, pp. 1043-1053. (doi: 10.1038/ncb3405)

Brown, S. H.J., Eather, S. R., Freeman, D. J., Meyer, B. J., Mitchell, T. W. (2016) A lipidomic analysis of placenta in preeclampsia: evidence for lipid storage PLoS ONE, 11, (doi: 10.1371/journal.pone.0163972)

Hood, K. Y., Yusuf, H., Findlay, J. E., Santos, R. A., Castro, C. H., Baillie, G. S., Montezano, A. C., MacLean, M. R., Touyz, R. M. (2016) ANG-(1-7) and ET-1, a new partnership Journal of Hypertension, 34, pp. e382. (doi: 10.1097/01.hjh.0000500977.99529.fe)

Hood, K. Y., Yusuf, H., Findlay, J. E., Santos, R. A., Castro, C. H., Baillie, G. S., MacLean, M. R., Montezano, A., Touyz, R. M. (2016) Ang(1-7) influences ET-1 signaling through Mas: ETBR interactions: implications in pulmonary hypertension Journal of Hypertension, 34, pp. e216. (doi: 10.1097/01.hjh.0000500475.07008.db)

Morgan, H., Small, H.Y., Beattie, E., McBride, M.W., Graham, D. (2016) [OP.5D.02] Transcriptomic changes in early pregnancy-associated uterine artery remodelling in stroke prone spontaneously hypertensive rat Journal of Hypertension, 34, pp. e63-e63. (doi: 10.1097/01.hjh.0000491501.79443.05)

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MacRitchie, N., Volpert, G., Al Washih, M., Watson, D. G., Futerman, A. H., Kennedy, S., Pyne, S., Pyne, N. J. (2016) Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension Cellular Signalling, 28, pp. 946-955. (doi: 10.1016/j.cellsig.2016.03.014)

Roscoe, R. B., Elliott, C., Zarros, A., Baillie, G. S. (2016) Non-genetic therapeutic approaches to Canavan disease Journal of the Neurological Sciences, 366, pp. 116-124. (doi: 10.1016/j.jns.2016.05.012)

Bachmann, V. A., Mayrhofer, J. E., Ilouz, R., Tschaikner, P. M., Raffeiner, P., Röck, R., Courcelles, M., Lu, T.-W., Baillie, G. S., Thibault, P., Aanstad, P., Stelzl, U., Taylor, S. S., Stefan, E. (2016) GPR61 anchoring of PKA consolidates GPCR and cAMP signaling Proceedings of the National Academy of Sciences of the United States of America, 113, pp. 7786-7791. (doi: 10.1073/pnas.1608061113)

Baillie, G. S. (2016) Editorial Cellular Signalling, 28, pp. 699-700. (doi: 10.1016/j.cellsig.2016.02.001)

Wills, L., Ehsan, M., Whiteley, E. L., Baillie, G. S. (2016) Location, location, location: PDE4D5 function is directed by its unique N-terminal region Cellular Signalling, 28, pp. 701-705. (doi: 10.1016/j.cellsig.2016.01.008)

Daly, C., Bulloch, J., Aidulis, D., Ma, M. (2016) The Design of Animations and Multimedia for Teaching

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Wan Sulaiman, W.N., Caslake, M.J., Delles, C., Karlsson, H., Mulder, M.T., Graham, D., Freeman, D.J. (2016) Does high-density lipoprotein protect vascular function in healthy pregnancy? Clinical Science, 130, pp. 491-497. (doi: 10.1042/cs20150475)

Jones, F. E., Bailey, M. A., Murray, L. S., Lu, Y., McNeilly, S., Schlötzer-Schrehardt, U., Lennon, R., Sado, Y., Brownstein, D. G., Mullins, J. J., Kadler, K. E., Van Agtmael, T. (2016) ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice Disease Models and Mechanisms, 9, pp. 165-76. (doi: 10.1242/dmm.021741)

McKittrick, C.M., Kennedy, S., Oldroyd, K.G., Mcginty, S., McCormick, C. (2016) Modelling the impact of atherosclerosis on drug release and distribution from coronary stents Annals of Biomedical Engineering, 44, pp. 477-487. (doi: 10.1007/s10439-015-1456-7)

Watt, J., Kennedy, S., Ahmed, N., Hayhurst, J., McClure, J. D., Berry, C., Wadsworth, R. M., Oldroyd, K. G. (2016) The relationship between oxidised LDL, endothelial progenitor cells and coronary endothelial function in patients with CHD Open Heart, 3, (doi: 10.1136/openhrt-2015-000342)

Dachtler, J., Elliott, C., Rodgers, R. J., Baillie, G. S., Clapcote, S. J. (2016) Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice Scientific Reports, 6, (doi: 10.1038/srep18748)

Small, H. Y., Morgan, H., Beattie, E., Griffin, S., Indahl, M., Delles, C., Graham, D. (2016) Abnormal uterine artery remodelling in the stroke prone spontaneously hypertensive rat Placenta, 37, pp. 34-44. (doi: 10.1016/j.placenta.2015.10.022)

Baillie, G. S., Christian, F., Zarros, A. (2016) Editorial: frontiers in the pharmacological manipulation of intracellular cAMP levels Frontiers in Pharmacology, 7, (doi: 10.3389/fphar.2016.00004)

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Meyer, B. J., Onyiaodike, C. C., Brown, E. A., Jordan, F., Murray, H., Nibbs, R. J. B., Sattar, N., Lyall, H., Nelson, S. M., Freeman, D. J. (2016) Maternal plasma DHA levels increase prior to 29 days post-LH surge in women undergoing frozen embryo transfer: a prospective, observational study of human pregnancy Journal of Clinical Endocrinology and Metabolism, 101, pp. 1745-1753. (doi: 10.1210/jc.2015-3089)

Tankou, S., Ishii, K., Elliott, C., Yalla, K., Kubo, K.-i., Brandon, N. J., Tang, Q., Hayward, G., Nakajima, K., Houslay, M., Kamiya, A., Baillie, G., Ishizuka, K., Sawa, A. (2016) SUMOylation of DISC1: a potential role in neural progenitor proliferation in the developing cortex Molecular Neuropsychiatry, 2, pp. 20-27. (doi: 10.1159/000444257)

Baeza-Raja, B., Sachs, B. D., Li, P., Christian, F., Vagena, E., Davalos, D., Le Moan, N., Ryu, J. K., Sikorski, S. L., Chan, J. P., Scadeng, M., Taylor, S. S., Houslay, M. D., Baillie, G. S., Saltiel, A. R., Olefsky, J. M., Akassoglou, K. (2016) p75 neurotrophin receptor regulates energy balance in obesity Cell Reports, 14, pp. 255-268. (doi: 10.1016/j.celrep.2015.12.028)


Baillie, G. S. (2015) George Baillie on peptide array, a technique that transformed research on phosphodiesterases Future Science OA, 1, (doi: 10.4155/fso.15.25)

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MacLeod, R., Hillert, E.-K., Cameron, R. T., Baillie, G. S. (2015) The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease Future Science OA, 1, (doi: 10.4155/fso.15.9)

Akehurst, C., Small, H., Sharafetdinova, L., Forrest, R., Beattie, W., Brown, C. E., Robinson, S. W., McClure, J. D., Work, L. M., Carty, D. M., McBride, M. W., Freeman, D. J., Delles, C. (2015) Differential expression of microRNA-206 and its target genes in pre-eclampsia Journal of Hypertension, 33, pp. 2068-2074. (doi: 10.1097/HJH.0000000000000656)

Sin, Y. Y., Baillie, G. (2015) Heat Shock Protein 20 (HSP20) is a novel substrate for Protein Kinase D1 (PKD1) Cell Biochemistry and Function, 33, pp. 421-426. (doi: 10.1002/cbf.3147)

Zoccarato, A., Surdo, N. C., Aronsen, J. M., Fields, L. A., Mancuso, L., Dodoni, G., Stangherlin, A., Livie, C., Jiang, H., Sin, Y. Y., Gesellchen, F., Terrin, A., Baillie, G. S., Nicklin, S. A., Graham, D., Szabo-Fresnais, N., Krall, J., Vandeput, F., Movsesian, M., Furlan, L., Corsetti, V., Hamilton, G. M., Lefkimmiatis, K., Sjaastad, I., Zaccolo, M. (2015) Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2 Circulation Research, 117, pp. 707-719. (doi: 10.1161/CIRCRESAHA.114.305892)

Wu, J., Grassia, G., Cambrook, H., Ialenti, A., MacRitchie, N., Carberry, J., Wadsworth, R. M., Lawrence, C., Kennedy, S., Maffia, P. (2015) Perivascular mast cells regulate vein graft neointimal formation and remodeling PeerJ, 3, (doi: 10.7717/peerj.1192)

Menni, C., Graham, D., Kastenmuller, G., Alharbi, N. H.J., Alsanos, S. M., McBride, M., Mangino, M., Titcombe, P., Shin, S.-Y., Psatha, M., Geisendorfer, T., Huber, A., Peters, A., Wang-Sattler, R., Xu, T., Brosnan, M. J., Trimmer, J., Reichel, C., Mohney, R. P., Soranzo, N., Edwards, M. H., Cooper, C., Church, A. C., Suhre, K., Gieger, C., Dominiczak, A. F., Spector, T. D., Padmanabhan, S., Valdes, A. M. (2015) Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate Hypertension, 66, pp. 422-429. (doi: 10.1161/HYPERTENSIONAHA.115.05544)

Mckinney, C.A., Kennedy, S., Baillie, G.S., Milligan, G., Nicklin, S.A. (2015) Angiotensin-(1-7) and angiotensin-(1-9) inhibit vascular smooth muscle cell growth and migration in vitro and vascular remodelling in vivo Atherosclerosis, 241, pp. e44. (doi: 10.1016/j.atherosclerosis.2015.04.158)

Zarros, A., Cameron, R.T., Bimpis, A., Baillie, G.S. (2015) Exposure of mHIPPOE-14 cells to oligomycin as a tool for in vitro approaches to brain ischaemia-related pro- and epiphenomena: time-dependent cellular response profiling Atherosclerosis, 241, pp. e221. (doi: 10.1016/j.atherosclerosis.2015.04.1038)

Parnell, E., Koschinski, A., Zaccolo, M., Cameron, R. T., Baillie, G. S., Baillie, G. L., Porter, A., McElroy, S. P., Yarwood, S. J. (2015) Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells Biochimica et Biophysica Acta: Molecular Cell Research, 1853, pp. 1749-1758. (doi: 10.1016/j.bbamcr.2015.04.009)

Dowsett, L., Piper, S., Slaviero, A., Dufton, N., Wang, Z., Boruc, O., Delahaye, M., Colman, L., Kalk, E., Tomlinson, J., Birdsey, G., Randi, A. M., Leiper, J. (2015) Endothelial dimethylarginine dimethylaminohydrolase 1 is an important regulator of angiogenesis but does not regulate vascular reactivity or hemodynamic homeostasis Circulation, 131, pp. 2217-2225. (doi: 10.1161/CIRCULATIONAHA.114.015064)

McDonald, R. A., Halliday, C. A., Miller, A. M., Diver, L. A., Dakin, R. S., Montgomery, J., McBride, M. W., Kennedy, S., McClure, J. D., Robertson, K. E., Douglas, G., Channon, K. M., Oldroyd, K., Baker, A. H. (2015) Reducing in-stent restenosis therapeutic manipulation of miRNA in vascular remodeling and inflammation Journal of the American College of Cardiology, 65, pp. 2314-2327. (doi: 10.1016/j.jacc.2015.03.549)

Lambden, S., Kelly, P., Ahmetaj-Shala, B., Wang, Z., Lee, B., Nandi, M., Torondel, B., Delahaye, M., Dowsett, L., Piper, S., Tomlinson, J., Caplin, B., Colman, L., Boruc, O., Slaviero, A., Zhao, L., Oliver, E., Khadayate, S., Singer, M., Arrigoni, F., Leiper, J. (2015) Dimethylarginine dimethylaminohydrolase 2 regulates nitric oxide synthesis and hemodynamics and determines outcome in polymicrobial sepsis Arteriosclerosis, Thrombosis, and Vascular Biology, 35, pp. 1382-1392. (doi: 10.1161/ATVBAHA.115.305278)

Greig, F. H., Hutchison, L., Spickett, C. M., Kennedy, S. (2015) Differential effects of chlorinated and oxidized phospholipids in vascular tissue: implications for neointima formation Clinical Science, 128, pp. 579-592. (doi: 10.1042/CS20140578)

Wang, L., Burmeister, B. T., Johnson, K. R., Baillie, G. S., Karginov, A. V., Skidgel, R. A., O'Bryan, J. P., Carnegie, G. K. (2015) UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy Cellular Signalling, 27, pp. 908-922. (doi: 10.1016/j.cellsig.2015.02.003)

Patil, K. C., McPherson, L., Daly, C. J. (2015) Co-localization of alpha1-adrenoceptors and GPR55: a novel prostate cancer paradigm? Pharmacology and Pharmacy, 6, pp. 212-220. (doi: 10.4236/pp.2015.64023)

Bolger, G. B., Dunlop, A. J., Meng, D., Day, J. P., Klussmann, E., Baillie, G. S., Adams, D. R., Houslay, M. D. (2015) Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains Cellular Signalling, 27, pp. 756-769. (doi: 10.1016/j.cellsig.2014.12.009)

Sin, Y. Y., Martin, T. P., Wills, L., Currie, S., Baillie, G. S. (2015) Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy Cell Communication and Signaling, 13, (doi: 10.1186/s12964-015-0094-x)

Rannikmäe, K., Davies, G., Thomson, P. A., Bevan, S., Devan, W. J., Falcone, G. J., Traylor, M., Anderson, C. D., Battey, T. W. K., Radmanesh, F., Deka, R., Woo, J. G., Martin, L. J., Jimenez-Conde, J., Selim, M., Brown, D. L., Silliman, S. L., Kidwell, C. S., Montaner, J., Langefeld, C. D., Slowik, A., Hansen, B. M., Lindgren, A. G., Meschia, J. F., Fornage, M., Bis, J. C., Debette, S., Ikram, M. A., Longstreth, W. T., Schmidt, R., Zhang, C. R., Yang, Q., Sharma, P., Kittner, S. J., Mitchell, B. D., Holliday, E. G., Levi, C. R., Attia, J., Rothwell, P. M., Poole, D. L., Boncoraglio, G. B., Psaty, B. M., Malik, R., Rost, N., Worrall, B. B., Dichgans, M., Van Agtmael, T., Woo, D., Markus, H. S., Seshadri, S., Rosand, J., Sudlow, C. L. M. (2015) Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease Neurology, 84, pp. 918-926. (doi: 10.1212/WNL.0000000000001309)

Skogstrand, T., Leh, S., McClure, J., Dashti, M., Iversen, B. M., Graham, D., McBride, M., Hultström, M. (2015) Identification of a common molecular pathway in hypertensive renal damage Journal of Hypertension, 33, pp. 584-596. (doi: 10.1097/HJH.0000000000000395)

Zarros, A., Johnson, S. A., Mackenzie-Gray Scott, C. A., Baillie, G. S. (2015) Cytodynamics and endpoint selection for a reliable in vitro assessment of nanoneurotoxicity Nanomedicine: Nanotechnology, Biology and Medicine, 11, pp. 407-408. (doi: 10.1016/j.nano.2014.08.014)

Kalafatakis, K., Gkanti, V., Mackenzie-Gray Scott, C. A., Zarros, A., Baillie, G. S., Tsakiris, S. (2015) Acetylcholinesterase activity as a neurotoxicity marker within the context of experimentally-simulated hyperprolinaemia: an in vitro approach Journal of Natural Science, Biology and Medicine, 6, pp. 98-101. (doi: 10.4103/0976-9668.166099)

McGinty, S., Wheel, M., McKee, S., McCormick, C., McKittrick, C., Kennedy, S., Oldroyd, K. (2015) Can Anisotropy Enhance the Spatial Uniformity of Drug Distribution in Biological Tissue?

Lopez, L. M., Hill, W. D., Harris, S. E., Valdes Hernandez, M., Munoz Maniega, S., Bastin, M. E., Bailey, E., Smith, C., McBride, M., McClure, J., Graham, D., Dominiczak, A., Yang, Q., Fornage, M., Ikram, M. A., Debette, S., Launer, L., Bis, J. C., Schmidt, R., Seshadri, S., Porteous, D. J., Starr, J., Deary, I. J., Wardlaw, J. M. (2015) Genes from a translational analysis support a multifactorial nature of white matter hyperintensities Stroke, 46, pp. 341-347. (doi: 10.1161/STROKEAHA.114.007649)

Escola-Gil, J.C., Julve, J., Griffin, B.A., Freeman, D.J., Blanco-Vaca, F. (2015) HDL and lifestyle interventions Springer Open

Bottcher, R., Henderson, D. J. P., Dulla, K., van Strijp, D., Waanders, L. F., Tevz, G., Lehman, M. L., Merkle, D., van Leenders, G. J. L. H., Baillie, G. S., Jenster, G., Houslay, M. D., Hoffmann, R. (2015) Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression British Journal of Cancer, 113, pp. 1502-1511. (doi: 10.1038/bjc.2015.335)

McGirr, A., Lipina, T. V., Mun, H.-S., Georgiou, J., Al-Amri, A. H., Ng, E., Zhai, D., Elliott, C., Cameron, R. T., Mullins, J. G., Liu, F., Baillie, G. S., Clapcote, S. J., Roder, J. C. (2015) Specific inhibition of phosphodiesterase-4B results in anxiolysis and facilitates memory acquisition Neuropsychopharmacology, 41, pp. 1080-1092. (doi: 10.1038/npp.2015.240)

Byrne, A. M., Elliott, C., Hoffmann, R., Baillie, G. S. (2015) The activity of cAMP-Phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus FEBS Letters, 589, pp. 750-755. (doi: 10.1016/j.febslet.2015.02.004)


Schoenherr, C., Serrels, B., Proby, C., Cunningham, D. L., Findlay, J. E., Baillie, G. S., Heath, J. K., Frame, M. (2014) Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells Journal of Cell Science, 127, pp. 5303-5316. (doi: 10.1242/jcs.157560)

Lawlor, D. A., West, J., Fairley, L., Nelson, S. M., Bhopal, R. S., Tuffnell, D., Freeman, D. J., Wright, J., Whitelaw, D. C., Sattar, N. (2014) Pregnancy glycaemia and cord-blood levels of insulin and leptin in Pakistani and white British mother–offspring pairs: findings from a prospective pregnancy cohort Diabetologia, 57, pp. 2492-2500. (doi: 10.1007/s00125-014-3386-6)

Campbell, A. S., Johnstone, S. R., Baillie, G. S., Smith, G. (2014) β-Adrenergic modulation of myocardial conduction velocity: Connexins vs. sodium current Journal of Molecular and Cellular Cardiology, 77, pp. 147-154. (doi: 10.1016/j.yjmcc.2014.09.030)

Lee, K. M., Danuser, R., Stein, J. V., Graham, D., Nibbs, R. J.B., Graham, G. J. (2014) The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density EMBO Journal, 33, pp. 2564-2580. (doi: 10.15252/embj.201488887)

Kaname, T., Ki, C.-S., Niikawa, N., Baillie, G. S., Day, J. P., Yamamura, K.-i., Ohta, T., Nishimura, G., Mastuura, N., Kim, O.-H., Sohn, Y. B., Kim, H. W., Cho, S. Y., Ko, A.-R., Lee, J. Y., Kim, H. W., Ryu, S. H., Rhee, H., Yang, K.-S., Joo, K., Lee, J., Kim, C. H., Cho, K.-H., Kim, D., Yanagi, K., Naritomi, K., Yoshiura, K.-i., Kondoh, T., Nii, E., Tonoki, H., Houslay, M. D., Jin, D.-K. (2014) Heterozygous mutations in cyclic AMP phosphodiesterase-4D (PDE4D) and protein kinase A (PKA) provide new insights into the molecular pathology of acrodysostosis Cellular Signalling, 26, pp. 2446-2459. (doi: 10.1016/j.cellsig.2014.07.025)

Christian, F., Krause, E., Houslay, M. D., Baillie, G. (2014) PKA phosphorylation of p62/SQSTM1 regulates PB1 domain interaction partner binding Biochimica et Biophysica Acta: Molecular Cell Research, 1843, pp. 2765-2774. (doi: 10.1016/j.bbamcr.2014.07.021)

Sampson, A. K., Mohammed, D., Beattie, W., Graham, D., Kenyon, C. J., Al-Dujaili, E. A.S., Guryev, V., McBride, M. W., Dominiczak, A. F. (2014) Introgressed chromosome 2 quantitative trait loci restores aldosterone regulation and reduces response to salt in the stroke-prone spontaneously hypertensive rat Journal of Hypertension, 32, pp. 2013-2021. (doi: 10.1097/HJH.0000000000000300)

Farmer, D. G.S., Ewart, M.-A., Mair, K. M., Kennedy, S. (2014) Soluble receptor for advanced glycation end products (sRAGE) attenuates haemodynamic changes to chronic hypoxia in the mouse Pulmonary Pharmacology and Therapeutics, 29, pp. 7-14. (doi: 10.1016/j.pupt.2014.01.002)

Zarros, A., Byrne, A.-M., Boomkamp, S. D., Tsakiris, S., Baillie, G. S. (2014) Erratum to: Lanthanum-induced neurotoxicity: solving the riddle of its involvement in cognitive impairment? Archives of Toxicology, 88, pp. 1767-1767. (doi: 10.1007/s00204-014-1307-6)

Sheppard, C. L., Lee, L. C.Y., Hill, E. V., Henderson, D. J.P., Anthony, D. F., Houslay, D. M., Yalla, K. C., Cairns, L. S., Dunlop, A. J., Baillie, G. S., Huston, E., Houslay, M. D. (2014) Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression Cellular Signalling, 26, pp. 1958-1974. (doi: 10.1016/j.cellsig.2014.04.023)

Zarros, A., Bimpis, A., Papalois, A., Baillie, G. S. (2014) Perihaematomal cytokine expression is a crucial component of intracerebral haemorrhage pathophysiology Neurological Sciences, 35, pp. 1471-1473. (doi: 10.1007/s10072-014-1785-6)

McCormick, K., Baillie, G. S. (2014) Compartmentalisation of second messenger signalling pathways Current Opinion in Genetics and Development, 27, pp. 20-25. (doi: 10.1016/j.gde.2014.02.001)

Lima-Fernandes, E., Misticone, S., Boularan, C., Paradis, J. S., Enslen, H., Roux, P. P., Bouvier, M., Baillie, G. S., Marullo, S., Scott, M. G.H. (2014) A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells Nature Communications, 5, (doi: 10.1038/ncomms5431)

Bulloch, J. M., Daly, C. J. (2014) Autonomic nerves and perivascular fat: interactive mechanisms Pharmacology and Therapeutics, 143, pp. 61-73. (doi: 10.1016/j.pharmthera.2014.02.005)

Cameron, R. T., Quinn, S. D., Cairns, L. S., MacLeod, R., Samuel, I. D.W., Smith, B. O., Penedo, J. C., Baillie, G. S. (2014) The phosphorylation of Hsp20 enhances its association with amyloid-β to increase protection against neuronal cell death Molecular and Cellular Neuroscience, 61, pp. 46-55. (doi: 10.1016/j.mcn.2014.05.002)

Bimpis, A., Baillie, G. S., Zarros, A. (2014) Cholinergic deregulation in traumatic brain injury could be a pathophysiology-related biphasic epiphenomenon Medical Journal of Malaysia, 69, pp. 148.

Ewart, M.-A., Kennedy, S., MacMillan, D., Raja, A. L.N., Watt, I. M., Currie, S. (2014) Altered vascular smooth muscle function in the ApoE knockout mouse during the progression of atherosclerosis Atherosclerosis, 234, pp. 154-161. (doi: 10.1016/j.atherosclerosis.2014.02.014)

Huda, S. S., Forrest, R., Paterson, N., Jordan, F., Sattar, N., Freeman, D. J. (2014) In preeclampsia, maternal third trimester subcutaneous adipocyte lipolysis is more resistant to suppression by insulin than in healthy pregnancy Hypertension, 63, pp. 1094-1101. (doi: 10.1161/HYPERTENSIONAHA.113.01824)

Martin, T. P., Currie, S., Baillie, G. S. (2014) The cardioprotective role of small heat-shock protein 20 Biochemical Society Transactions, 42, pp. 270-273. (doi: 10.1042/BST20130272)

Husi, H., Van Agtmael, T., Mullen, W., Bahlmann, F. H., Schanstra, J. P., Vlahou, A., Delles, C., Perco, P., Mischak, H. (2014) Proteome-based systems biology analysis of the diabetic mouse aorta reveals major changes in fatty acid biosynthesis as potential hallmark in diabetes mellitus-associated vascular disease Circulation: Cardiovascular Genetics, 7, pp. 161-170. (doi: 10.1161/CIRCGENETICS.113.000196)

Shafaroudi, M. M., Daly, C. J. (2014) Endothelial vasodilator angiotensin receptors are changing in mice with ageing Research in Molecular Medicine, 2, pp. 26-34. (doi: 10.18869/acadpub.rmm.2.1.26)

Henderson, D.J.P., Byrne, A., Dulla, K., Jenster, G., Hoffmann, R., Baillie, G.S., Houslay, M.D. (2014) The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells British Journal of Cancer, 110, pp. 1278-1287. (doi: 10.1038/bjc.2014.22)

McLachlan, J., Beattie, E., Murphy, M. P., Koh-Tan, C. H.H., Olson, E., Beattie, W., Dominiczak, A. F., Nicklin, S. A., Graham, D. (2014) Combined therapeutic benefit of mitochondria-targeted antioxidant, MitoQ10, and angiotensin receptor blocker, losartan, on cardiovascular function Journal of Hypertension, 32, pp. 555-564. (doi: 10.1097/HJH.0000000000000054)

Graham, L. A., Padmanabhan, S., Fraser, N. J., Kumar, S., Bates, J. M., Raffi, H. S., Welsh, P., Beattie, W., Hao, S., Leh, S., Hultstrom, M., Ferreri, N. R., Dominiczak, A. F., Graham, D., McBride, M. W. (2014) Validation of uromodulin as a candidate gene for human essential hypertension Hypertension, 63, pp. 551-558. (doi: 10.1161/HYPERTENSIONAHA.113.01423)

Almabrouk, T.A.M., Ewart, M.-A., Salt, I.P., Kennedy, S. (2014) Perivascular fat, AMP-activated protein kinase and vascular diseases British Journal of Pharmacology, 171, pp. 595-617. (doi: 10.1111/bph.12479)

Campbell, A. S., Burton, F. L., Baillie, G., Smith, G. L. (2014) Action potential conduction velocity is increased by raised intracellular camp in the intact rat heart via a CaMKII mediated pathway

Murray, L.S., Lu, Y., Taggart, A., Van Regemorter, N., Vilain, C., Abramowicz, M., Kadler, K.E., Van Agtmael, T. (2014) Chemical chaperone treatment reduces intracellular accumulation of mutant collagen IV and ameliorates the cellular phenotype of a COL4A2 mutation that causes haemorrhagic stroke Human Molecular Genetics, 23, pp. 283-292. (doi: 10.1093/hmg/ddt418)

Youn, S., Budatha, M., Baillie, G., Schwartz, M. (2014) ECM-specific endothelial inflammatory signaling: regulation by integrin alpha5 interaction with PDE4D (doi: 10.1007/s10456-013-9412-3)

Quinn, S. D.., Dalgarno, P. A., Cameron, R. T., Hedley, G. J., Hacker, C., Lucocq, J. M., Baillie, G. S., Samuel, I. D.W., Penedo, J. C. (2014) Real-time probing of β-amyloid self-assembly and inhibition using fluorescence self-quenching between neighbouring dyes Molecular BioSystems, 10, pp. 34. (doi: 10.1039/c3mb70272c)

Cameron, R.T., Baillie, G.S. (2014) Arrestin regulation of small GTPases Springer

Willis, M.J., Baillie, G.S. (2014) Arrestin-dependent localization of phosphodiesterases Springer

Bailey, E. L., McBride, M. W., Crawford, W., McClure, J. D., Graham, D., Dominiczak, A. F., Sudlow, C. L.M., Smith, C., Wardlaw, J. M. (2014) Differential gene expression in multiple neurological, inflammatory and connective tissue pathways in a spontaneous model of human small vessel stroke Neuropathology and Applied Neurobiology, 40, pp. 855-872. (doi: 10.1111/nan.12116)

Baud, A., Guryev, V., Hummel, O., Johannesson, M., Hermsen, R., Stridh, P., Graham, D., McBride, M. W., Foroud, T., Calderari, S., Diez, M., Ockinger, J., Beyeen, A. D., Gillett, A., Abdelmagid, N., Guerreiro-Cacais, A. O., Jagodic, M., Tuncel, J., Norin, U., Beattie, E., Huynh, N., Miller, W. H., Koller, D. L., Alam, I., Falak, S., Osborne-Pellegrin, M., Martinez-Membrives, E., Canete, T., Blazquez, G., Vicens-Costa, E., Mont-Cardona, C., Diaz-Moran, S., Tobena, A., Zelenika, D., Saar, K., Patone, G., Bauerfeind, A., Bihoreau, M.-T., Heinig, M., Lee, Y.-A., Rintisch, C., Schulz, H., Wheeler, D. A., Worley, K. C., Muzny, D. M., Gibbs, R. A., Lathrop, M., Lansu, N., Toonen, P., Ruzius, F. P., de Bruijn, E., Hauser, H., Adams, D. J., Keane, T., Atanur, S. s., Aitman, T. J., Flicek, P., Malinauskas, T., Jones, E. Y., Ekman, D., Lopez-Aumatell, R., Dominiczak, A. F., Holmdahl, R., Olsson, T., Gauguier, D., Hubner, N., Fernandez-Teruel, A., Cuppen, E., Mott, R., Flint, J. (2014) Genomes and phenomes of a population of outbred rats and its progenitors Scientific Data, 1, (doi: 10.1038/sdata.2014.11)

Sampson, A. K., Andrews, K. L., Graham, D., McBride, M. W., Head, G. A., Thomas, M. C., Chin-Dusting, J. P.F., Dominiczak, A. F., Jennings, G. L. (2014) Origin of the y chromosome influences intrarenal vascular responsiveness to angiotensin i and angiotensin (1-7) in stroke-prone spontaneously hypertensive rats Hypertension, 64, pp. 1376-1383. (doi: 10.1161/HYPERTENSIONAHA.114.03756)

Weninger, S., Van Craenenbroeck, K., Cameron, R., Vandeput, F., Movsesian, M.A., Baillie, G.S., Lefebvre, R.A. (2014) Phosphodiesterase 4 interacts with the 5-HT4(b) receptor to regulate cAMP signaling Cellular Signalling, 26, pp. 2573-2582. (doi: 10.1016/j.cellsig.2014.07.027)

Martin, T. P., Hortigon-Vinagre, M. P., Findlay, J. E., Elliott, C., Currie, S., Baillie, G. S. (2014) Targeted disruption of the heat shock protein 20–phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy FEBS Open Bio, 4, pp. 923-927. (doi: 10.1016/j.fob.2014.10.011)

Padmanabhan, S., Graham, L., Ferreri, N. R., Graham, D., McBride, M., Dominiczak, A. (2014) Uromodulin, an emerging novel pathway for blood pressure regulation and hypertension Hypertension, 64, pp. 918-923. (doi: 10.1161/HYPERTENSIONAHA.114.03132)

It is now apparent that adipose tissue is highly heterogenous and plastic, exhibiting depot-specific functions regulated by multiple mechanisms that are not fully characterised and understood. There is increasing interest in the (patho)physiological roles of inflammatory, immunometabolic, adipogenic and “beiging” pathways within adipose tissue as these represent potential therapeutic targets to aid with weight loss and address pathophysiological consequences of adipose tissue dysfunction. Furthermore, determining the mechanisms by which adipose influences other tissues and how variables such as sex, age, deprivation and ethnicity impact on these is necessary.

Ongoing research topics include:

  • Adipocyte function and differentiation in south Asians and in sepsis
  • Ectopic fat, adipose tissue fibrosis, adipocyte differentiation, lipid metabolism in pregnancy and its metabolic complications (gestational diabetes mellitus and pre-eclampsia)
  • The role of insulin signalling in vascular tissues
  • The role of AMP-activated protein kinase as a regulator of metabolic health
  • The role of asymmetric dimethylarginine in metabolic tissue function

We will characterise the molecular and cellular mechanisms by which altered adipose tissue function and ectopic fat contributes to metabolic disease. Therefore this research will contribute to identifying novel mechanisms regulating adipose tissue function and potential therapeutic targets for obesity and related pathophysiology across the lifecourse.