Cellular signalling & Mechanisms

Our aim is to understand molecular and cellular components within metabolic tissues, how they contribute to adipose tissue expansion, and the consequences of their dysfunction in metabolic diseases.




Ramses, R., Kennedy, S., Good, R., Oldroyd, K. G., Mcginty, S. (2024) Performance of drug-coated balloons in coronary and below-the-knee arteries: anatomical, physiological and pathological considerations. Vascular Pharmacology, 155, (doi: 10.1016/j.vph.2024.107366)

Loughrey, C. et al. (2024) A novel ryanodine receptor 2 inhibitor, M201-A, enhances natriuresis, renal function and lusi-inotropic action: Pre-clinical and phase I study. British Journal of Pharmacology,

Hoare, D., Kingsmore, D., Holsgrove, M., Russell, E., Kirimi, M. T., Czyzewski, J., Mirzai, N., Kennedy, S., Neale, S. L., Mercer, J. R. (2024) Realtime monitoring of thrombus formation in vivo using a self-reporting vascular access graft. Communications Medicine, 4, (doi: 10.1038/s43856-024-00436-8)

Mary, S., Conti-Ramsden, F., Boder, P., Parveen, H., Setjiadi, D., Fleminger, J., Brockbank, A., Graham, D., Bramham, K., Chappell, L. C., Delles, C. (2024) Pregnancy-associated changes in urinary uromodulin excretion in chronic hypertension. Journal of Nephrology, (doi: 10.1007/s40620-023-01830-6)

McFall, A., Graham, D., Nicklin, S. A., Work, L. M. (2024) Unscheduled changes in pre-clinical stroke model housing contributes to variance in physiological and behavioural data outcomes: a post hoc analysis. Brain and Neuroscience Advances, 8, (doi: 10.1177/23982128241238934)


Gulliver, C., Busiau, T., Byrne, A., Findlay, J. E., Hoffmann, R., Baillie, G. (2023) cAMP-phosphodiesterase 4D7 (PDE4D7) forms a cAMP signalosome complex with DHX9 and is implicated in prostate cancer progression. Molecular Oncology, (doi: 10.1002/1878-0261.13572)

Freeman-Jones, E., Miller, W. H., Work, L. M., Fullerton, J. L. (2023) Polypathologies and animal models of traumatic brain injury. Brain Sciences, 13, (doi: 10.3390/brainsci13121709)

Lyon, M., Fullerton, J. L., Kennedy, S., Work, L. M. (2023) Hypertension & dementia: pathophysiology & potential utility of antihypertensives in reducing disease burden. Pharmacology and Therapeutics, (doi: 10.1016/j.pharmthera.2023.108575)

Martin, T. P., MacDonald, E. A., Bradley, A., Watson, H., Saxena, P., Rog-Zielinska, E. A., Raheem, A., Fisher, S., Elbassioni, A. A. M., Almuzaini, O., Booth, C., Campbell, M., Riddell, A., Herzyk, P., Blyth, K., Nixon, C., Zentilin, L., Berry, C., Braun, T., Giacca, M., McBride, M. W., Nicklin, S. R., Cameron, E. R., Loughrey, C. (2023) Ribonucleicacid interference or small molecule inhibition of Runx1 in the border zone prevents cardiac contractile dysfunction following myocardial infarction. Cardiovascular Research, 119, pp. 2663–2671-2663–2671. (doi: 10.1093/cvr/cvad107)

Irshad, Z., Lund, J., Sillars, A., Løvsletten, N. G., Gharanei, S., Salt, I. P., Freeman, D. J., Gill, J. M.R., Thoresen, G. H., Rustan, A. C., Zammit, V. A. (2023) The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background. FASEB Journal, 37, (doi: 10.1096/fj.202300960RR)

Gulliver, C., Baillie, G. S., Hoffmann, R. (2023) Reduced PDE4D7 in prostate cancer correlates with genomic downregulation within the upstream PDE4D coding region. Future Science OA, 9, (doi: 10.2144/fsoa-2023-0064)

Parsons, E. C., Baillie, G. S., Hoffmann, R. (2023) Revisiting the roles of cAMP signalling in the progression of prostate cancer. Biochemical Journal, 480, pp. 1599-1614. (doi: 10.1042/BCJ20230297)

Meyer, B. J., Cortie, C., Dekker-Nitert, M., Barrett, H. L., Freeman, D. J. (2023) Women with gestational diabetes mellitus, controlled for plasma glucose level, exhibit maternal and fetal dyslipidaemia that may warrant treatment. Diabetes Research and Clinical Practice, 204, (doi: 10.1016/j.diabres.2023.110929)

Gulliver, C., Huss, S., Semjonow, A., Baillie, G. S., Hoffmann, R. (2023) Loss of PDE4D7 expression promotes androgen independence, neuroendocrine differentiation, and alterations in DNA repair: implications for therapeutic strategies. British Journal of Cancer, (doi: 10.1038/s41416-023-02417-5)

Wright, T. A., Gemmell, A. O., Tejeda, G. S., Blair, C. M., Baillie, G. S. (2023) Cancer: phosphodiesterase type 4C (PDE4C), the forgotten subfamily as a therapeutic target. International Journal of Biochemistry and Cell Biology, 162, (doi: 10.1016/j.biocel.2023.106453)

Zorn, A., Baillie, G. (2023) Phosphodiesterase 7 as a therapeutic target – Where are we now? Cellular Signalling, 108, (doi: 10.1016/j.cellsig.2023.110689)

Olivera, S., Graham, D. (2023) Sex differences in preclinical models of hypertension. Journal of Human Hypertension, 37, pp. 619-625. (doi: 10.1038/s41371-022-00770-1)

Paes, D., Schepers, M., Willems, E., Rombaut, B., Tiane, A., Solomina, Y., Tibbo, A., Blair, C., Kyurkchieva, E., Baillie, G. S., Ricciarelli, R., Brullo, C., Fedele, E., Bruno, O., van den Hove, D., Vanmierlo, T., Prickaerts, J. (2023) Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology. Cellular and Molecular Life Sciences, 80, (doi: 10.1007/s00018-023-04804-w)

Dowsett, L., Duluc, L., Higgins, E., Alghamdi, F., Fast, W., Salt, I. P., Leiper, J. (2023) Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cellular Signalling, 107, (doi: 10.1016/j.cellsig.2023.110676)

Kyurkchieva, E., Baillie, G. S. (2023) Short PDE4 isoforms as drug targets in disease. Frontiers in Bioscience: Landmark, 28, (doi: 10.31083/j.fbl2807133)

Brown, A. D., Vergunst, K. L., Branch, M., Blair, C. M., Dupré, D. J., Baillie, G. S., Langelaan, D. N. (2023) Structural basis of CBP/p300 recruitment by the microphthalmia-associated transcription factor. Biochimica et Biophysica Acta: Molecular Cell Research, (doi: 10.1016/j.bbamcr.2023.119520)

Fullerton, J., Bettencourt, C., Daniels, M., Mclean, F., Simpson, S., Smith, A., Woodling, N., Kerr, F. (2023) Creating connections: developing an online space for cross-regional mentorship and network building in the dementia research field. Health Open Research, 4, (doi: 10.12688/amrcopenres.13091.2)

Gulliver, C., Huss, S., Semjonow, A., Baillie, G. S., Hoffmann, R. (2023) The CAPRA&PDE4D5/7/9 prognostic model is significantly associated to adverse post-surgical pathology outcomes. Cancers, 15, (doi: 10.3390/cancers15010262)


Gerganova, G., Riddell, A., Miller, A. A. (2022) CNS border-associated macrophages in the homeostatic and ischaemic brain. Pharmacology and Therapeutics, 240, (doi: 10.1016/j.pharmthera.2022.108220)

Kumar, A. A., Yeo, N., Whittaker, M., Attra, P., Barrick, T. R., Bridges, L. R., Dickson, D. W., Esiri, M. M., Farris, C. W., Graham, D., Lin, W. L., Meijles, D. N., Pereira, A. C., Perry, G., Rosene, D. L., Shtaya, A. B., Van Agtmael, T., Zamboni, G., Hainsworth, A. H. (2022) Vascular collagen type-IV in hypertension and cerebral small vessel disease. Stroke, 53, pp. 3696-3705. (doi: 10.1161/STROKEAHA.122.037761)

Mary, S., Boder, P., Padmanabhan, S., McBride, M. W., Graham, D., Delles, C., Dominiczak, A. F. (2022) The role of uromodulin in salt-sensitive hypertension. Hypertension, 79, pp. 2419-2429. (doi: 10.1161/HYPERTENSIONAHA.122.19888)

Main, A., Bogusalvskyii, A., Howie, J., Kuo, C.-W., Rankin, A., Burton, F. L., Smith, G. L., Hajjar, R., Baillie, G. S., Campbell, K. S., Shattock, M. J., Fuller, W. (2022) Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies. Frontiers in Physiology, 13, (doi: 10.3389/fphys.2022.1023237)

Reel, P. S. et al. (2022) Machine learning for classification of hypertension subtypes using multi-omics: a multi-centre, retrospective, data-driven study. EBioMedicine, 84, (doi: 10.1016/j.ebiom.2022.104276)

Fertig, B., Ling, J., Nollet, E. E., Dobi, S., Busiau, T., Ishikawa, K., Yamada, K., Lee, A., Kho, C., Wills, L., Tibbo, A. J., Scott, M., Grant, K., Campbell, K. S., Birks, E. J., MacQuaide, N., Hajjar, R., Smith, G. L., van der Velden, J., Baillie, G. (2022) SUMOylation does not affect cardiac troponin I stability but alters indirectly the development of force in response to Ca2+ FEBS Journal, 289, pp. 6267-6285. (doi: 10.1111/febs.16537)

McQueen, A., Escuer, J., Schmidt, A. F., Aggarwal, A., Kennedy, S., McCormick, C., Oldroyd, K., Mcginty, S. (2022) An intricate interplay between stent drug dose and release rate dictates arterial restenosis. Journal of Controlled Release, 349, pp. 992-1008. (doi: 10.1016/j.jconrel.2022.07.037)

Daly, C., Briddon, S. (2022) Pharmacology in the Metaverse. Pharmacology Matters, 2022,

Stathopoulou, K., Schnittger, J., Raabe, J., Fleischer, F., Mangels, N., Piasecki, A., Findlay, J., Hartmann, K., Krasemann, S., Schlossarek, S., Uebeler, J., Wixler, V., Blake, D. J., Baillie, G., Carrier, L., Ehler, E., Cuello, F. (2022) CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes. FEBS Journal, 289, pp. 4622-4645. (doi: 10.1111/febs.16402)

Gulliver, C., Hoffmann, R., Baillie, G. S. (2022) Ataxia-telangiectasia mutated and ataxia telangiectasia and Rad3-related kinases as therapeutic targets and stratification indicators for prostate cancer. International Journal of Biochemistry and Cell Biology, 147, (doi: 10.1016/j.biocel.2022.106230)

Fullerton, J. L., Thomas, J. M., Gonzalez-Trueba, L., Trivett, C., Van Kralingen, J. C., Allan, S. M., Quinn, T. J., Work, L. M. (2022) Systematic review: association between circulating microRNA expression & stroke. Journal of Cerebral Blood Flow and Metabolism, 42, pp. 935-951. (doi: 10.1177/0271678X221085090)

Beazer, J. D., Freeman, D. J. (2022) Estradiol and HDL function in women – a partnership for life. Journal of Clinical Endocrinology and Metabolism, 107, pp. e2192-2194. (doi: 10.1210/clinem/dgab811)

He, W. et al. (2022) Inhibition of myocardial cathepsin-L release during reperfusion following myocardial infarction improves cardiac function and reduces infarct size. Cardiovascular Research, 118, pp. 1535-1547. (doi: 10.1093/cvr/cvab204)

Malfait, F., Forlino, A., Sengle, G., Van Agtmael, T. (2022) Editorial: molecular mechanisms of heritable connective tissue disorders. Frontiers in Genetics, 13, (doi: 10.3389/fgene.2022.866665)

Fullerton, J. L., Cosgrove, C. C., Rooney, R. A., Work, L. (2022) Extracellular vesicles and their microRNA cargo in ischaemic stroke. Journal of Physiology, (doi: 10.1113/JP282050)

Tibbo, A. J., Mika, D., Dobi, S., Ling, J., McFall, A., Tejeda, G. S., Blair, C., MacLeod, R., MacQuaide, N., Gök, C., Fuller, W., Smith, B. O., Smith, G. L., Vandecasteele, G., Brand, T., Baillie, G. S. (2022) Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins. Journal of Molecular and Cellular Cardiology, 165, pp. 86-102. (doi: 10.1016/j.yjmcc.2022.01.001)

Dritsoula, A., Dowsett, L., Pilotti, C., O'Connor, M. N., Moss, S. E., Greenwood, J. (2022) Angiopathic activity of LRG1 is induced by the IL-6/STAT3 pathway. Scientific Reports, 12, (doi: 10.1038/s41598-022-08516-2)

Martin, T. P., MacDonald, E. A., Elbassioni, A. A., Zaeri, A. A. I., O'Toole, D., Nicklin, S. A., Gray, G. A., Loughrey, C. M. (2022) Pre-clinical models of myocardial infarction: from mechanism to translation. British Journal of Pharmacology, 179, pp. 770-791. (doi: 10.1111/bph.15595)

Stoyek, M. R., MacDonald, E., Mantifel, M., Baillie, J. S., Selig, B. M., Croll, R. P., Smith, F. M., Quinn, T. A. (2022) Drivers of sinoatrial node automaticity in zebrafish: comparison with mechanisms of mammalian pacemaker function. Frontiers in Physiology, 13, (doi: 10.3389/fphys.2022.818122)

Bakalchuk, S., Walker, C., Daly, C., Hill, L., Poyade, M. (2022) Creating interactive three-dimensional applications to visualise novel stent grafts that aid in the treatment of aortic aneurysms. Springer

Douglass, A., Moffat, G., Daly, C. (2022) Using confocal microscopy to generate an accurate vascular model for use in patient education animation. Springer

Baillie, G., Kyurkchieva, E., Sin, Y. Y., Ahmed, F., Rajapakse, N., Schoolmeesters, A., Richard, N., Erdman, P., Hecht, D., Chourasia, A. H., Mercurio, F., Fung, L., Chan, K., Stirling, D. (2022) Evaluating the Utility of Bi-functional Degrader Molecules for Selective Inhibition of PDE4 In Acrodysostosis Type2.


Trivett, C., Lees, Z. J., Freeman, D. J. (2021) Adipose tissue function in healthy pregnancy, gestational diabetes mellitus and pre-eclampsia. European Journal of Clinical Nutrition, 75, pp. 1745-1756. (doi: 10.1038/s41430-021-00948-9)

Omar, R., Malfait, F., Van Agtmael, T. (2021) Four decades in the making: collagen III and mechanisms of vascular Ehlers Danlos Syndrome. Matrix Biology Plus, 12, (doi: 10.1016/j.mbplus.2021.100090)

Alsufyani, H. A., Daly, C., Docherty, J. R. (2021) Interaction between α 1B ‐ and other α 1 ‐ and α 2 ‐adrenoceptors in producing contractions of mouse spleen. Basic and Clinical Pharmacology and Toxicology, 129, pp. 416-426. (doi: 10.1111/bcpt.13639)

Mary, S., Boder, P., Rossitto, G., Graham, L., Scott, K., Flynn, A., Kipgen, D., Graham, D., Delles, C. (2021) Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats. Clinical Science, 135, pp. 2749-2761. (doi: 10.1042/CS20211017)

Mahindra, A., Tejeda, G., Rossi, M., Janha, O., Herbert, I., Morris, C., Morgan, D. C., Beattie, W., Montezano, A. C., Hudson, B., Tobin, A. B., Bhella, D., Touyz, R. M., Jamieson, A. G., Baillie, G. S., Blair, C. M. (2021) Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction. PLoS ONE, 16, (doi: 10.1371/journal.pone.0260283)

O'Connor, M. N., Kallenberg, D. M., Camilli, C., Pilotti, C., Dritsoula, A., Jackstadt, R., Bowers, C. E., Watson, H. A., Alatsatianos, M., Ohme, J., Dowsett, L., George, J., Blackburn, J. W.D., Wang, X., Singhal, M., Augustin, H. G., Ager, A., Sansom, O. J., Moss, S. E., Greenwood, J. (2021) LRG1 destabilizes tumor vessels and restricts immunotherapeutic potency. Med, 2, pp. 1231-1252.e10. (doi: 10.1016/j.medj.2021.10.002)

MacKenzie, S. M., Saunders, H., van Kralingen, J. C., Robertson, S., Riddell, A., Zennaro, M.-C., Davies, E. (2021) Circulating microRNAs as diagnostic markers in primary aldosteronism. Cancers, 13, (doi: 10.3390/cancers13215312)

MacDonald, E. A., Quinn, T. A. (2021) What keeps us ticking? Sinoatrial node mechano-sensitivity: the grandfather clock of cardiac rhythm. Biophysical Reviews, 13, pp. 707-716. (doi: 10.1007/s12551-021-00831-8)

Pokhilko, A., Brezzo, G., Handunnetthi, L., Heilig, R., Lennon, R., Smith, C., Allan, S. M., Granata, A., Sinha, S., Wang, T., Markus, H. S., Naba, A., Fischer, R., Van Agtmael, T., Horsburgh, K., Cader, M. Z. (2021) Global proteomic analysis of extracellular matrix in mouse and human brain highlights relevance to cerebrovascular disease. Journal of Cerebral Blood Flow and Metabolism, 41, pp. 2423-2438. (doi: 10.1177/0271678X211004307)

Buist, H. K., Luchowska-Stańska, U., van Basten, B., Valli, J., Smith, B. O., Baillie, G. S., Rickman, C., Ricketts, B., Davidson, A., Hannam, R., Sunderland, J., Yarwood, S. J. (2021) Identification and characterization of an affimer affinity reagent for the detection of the cAMP sensor, EPAC1. Cells, 10, (doi: 10.3390/cells10092307)

Alves-Lopes, R., Montezano, A. C., Neves, K. B., Harvey, A., Rios, F. J., Skiba, D. S., Arendse, L. B., Guzik, T. J., Graham, D., Poglitsch, M., Sturrock, E., Touyz, R. M. (2021) Selective inhibition of the C-domain of ACE (angiotensin-converting enzyme) combined with inhibition of NEP (neprilysin): a potential new therapy for hypertension. Hypertension, 78, pp. 604-616. (doi: 10.1161/HYPERTENSIONAHA.121.17041)

Patanapirunhakit, P., Karlsson, H., Mulder, M., Ljunggren, S., Graham, D., Freeman, D. (2021) Sphingolipids in HDL – potential markers for adaptation to pregnancy? Biochimica et Biophysica Acta: Molecular and Cell Biology of Lipids, 1866, (doi: 10.1016/j.bbalip.2021.158955)

Boland, E., Quondamatteo, F., Van Agtmael, T. (2021) The role of basement membranes in cardiac biology and disease. Bioscience Reports, 41, pp. BSR20204185. (doi: 10.1042/bsr20204185)

Chung, J. et al. (2021) Rare missense functional variants at COL4A1 and COL4A2 in sporadic intracerebral hemorrhage. Neurology, 97, pp. e236-e247. (doi: 10.1212/WNL.0000000000012227)

Randles, M., Lausecker, F., Kong, Q., Suleiman, H., Reid, G., Kolatsi-Joannou, M., Tian, P., Falcone, S., Davenport, B., Potter, P., Van Agtmael, T., Norman, J., Long, D., Humphries, M., Miner, J., Lennon, R. (2021) Identification of an altered matrix signature in kidney aging and disease. Journal of the American Society of Nephrology, 32, pp. 1713-1732. (doi: 10.1681/ASN.2020101442)

Morgan, D. C., Morris, C., Mahindra, A., Blair, C. M., Tejeda, G., Herbert, I., Turnbull, M. L., Lieber, G., Willett, B. J., Logan, N., Smith, B., Tobin, A. B., Bhella, D., Baillie, G. S., Jamieson, A. G. (2021) Stapled ACE2 peptidomimetics designed to target the SARS-CoV-2 spike protein do not prevent virus internalisation. Peptide Science, 113, (doi: 10.1002/pep2.24217)

Reuten, R. et al. (2021) Basement membrane stiffness determines metastases formation. Nature Materials, 20, pp. 892-903. (doi: 10.1038/s41563-020-00894-0)

McQueen, A., Escuer, J., Aggarwal, A., Kennedy, S., McCormick, C., Oldroyd, K., Mcginty, S. (2021) Do we really understand how drug eluted from stents modulates arterial healing? International Journal of Pharmaceutics, 601, (doi: 10.1016/j.ijpharm.2021.120575)

Schofield, C. L., Rodrigo-Navarro, A., Dalby, M. J., Van Agtmael, T., Salmeron-Sanchez, M. (2021) Biochemical­­– and biophysical–induced barriergenesis in the blood brain barrier: a review of barriergenic factors for use in in vitro models. Advanced NanoBiomed Research, 1, (doi: 10.1002/anbr.202000068)

Dean, A., Van Agtmael, T. (2021) Collagen IV-related diseases and therapies. Springer

Scott, K., Morgan, H. L., Delles, C., Fisher, S., Graham, D., McBride, M. W. (2021) Distinct uterine artery gene expression profiles during early gestation in the stroke-prone spontaneously hypertensive rat. Physiological Genomics, 53, pp. 160-171. (doi: 10.1152/physiolgenomics.00159.2020)

Scott, M., Blondel-Tepaz, E., Leverve, M., Sokrat, B., Paradis, J., Kosic, M., Saha, K., Auffray, C., Lima-Fernandes, E., Zamborlini, A., Poupon, A., Gaboury, L., Findlay, J., Baillie, G., Enslen, H., Bouvier, M., Angers, S., Marullo, S. (2021) The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signalling axis. Oncogene, 40, pp. 2243-2257. (doi: 10.1038/s41388-021-01704-w)

Baillie, G. S., Gulliver, C., Hoffmann, R. (2021) The enigmatic helicase DHX9 and its association with the hallmarks of cancer. Future Science OA, 7, (doi: 10.2144/fsoa-2020-0140)


Abdulqader, A., Kennedy, S. (2020) The influence of perivascular adipose tissue on vascular function in a rabbit model. Pharmacology and Pharmacy, 11, pp. 331-349. (doi: 10.4236/pp.2020.1112027)

Zamai, N., Cortie, C. H., Jarvie, E. M., Onyiaodike, C. C., Alrehaili, A., Francois, M., Freeman, D. J., Meyer, B. J. (2020) In pregnancy, maternal HDL is specifically enriched in, and carries the highest proportion of, DHA in plasma. Prostaglandins, Leukotrienes and Essential Fatty Acids, 163, (doi: 10.1016/j.plefa.2020.102209)

Main, A., Fuller, W., Baillie, G. S. (2020) Post-translational regulation of cardiac myosin binding protein-C: a graphical review. Cellular Signalling, 76, (doi: 10.1016/j.cellsig.2020.109788)

Beazer, J. D., Patanapirunhakit, P., Gill, J. M.R., Graham, D., Karlsson, H., Ljunggren, S., Mulder, M., Freeman, D. J. (2020) High-density lipoprotein’s vascular protective functions in metabolic and cardiovascular disease - could extracellular vesicles be at play? Clinical Science, 134, pp. 2977-2986. (doi: 10.1042/CS20200892)

Dowsett, L., Higgins, E., Alanazi, S., Alshuwayer, N. A., Leiper, F. C., Leiper, J. (2020) ADMA: A key player in the relationship between vascular dysfunction and inflammation in atherosclerosis. Journal of Clinical Medicine, 9, (doi: 10.3390/jcm9093026)

Ngandu Mpoyi, E., Cantini, M., Sin, Y. Y., Fleming, L., Zhou, D. W., Costell, M., Lu, Y., Kadler, K., García, A. J., Van Agtmael, T., Salmeron-Sanchez, M. (2020) Material-driven fibronectin assembly rescues matrix defects due to mutations in collagen IV in fibroblasts. Biomaterials, 252, (doi: 10.1016/j.biomaterials.2020.120090)

Rossitto, G., Mary, S., Chen, J. Y., Bodder, P., Chew, K. S., Neves, K. B., Alves, R. L., Montezano, A. C., Welsh, P., Petrie, M. C., Graham, D., Touyz, R. M., Delles, C. (2020) Tissue sodium excess is not hypertonic and reflects extracellular volume expansion. Nature Communications, 11, (doi: 10.1038/s41467-020-17820-2)

Zou, Z.-G., Rios, F. J., Neves, K. B., Alves-Lopes, R., Ling, J., Baillie, G. S., Gao, X., Fuller, W., Camargo, L. L., Gudermann, T., Chubanov, V., Montezano, A. C., Touyz, R. M. (2020) Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function. Clinical Science, 134, pp. 2019-2035. (doi: 10.1042/CS20200827)

MacDonald, E. A., Madl, J., Greiner, J., Ramadan, A. F., Wells, S. M., Torrente, A. G., Kohl, P., Rog-Zielinska, E. A., Quinn, T. A. (2020) Sinoatrial node structure, mechanics, electrophysiology and the chronotropic response to stretch in rabbit and mouse. Frontiers in Physiology, 11, (doi: 10.3389/fphys.2020.00809)

Riddell, A., McBride, M., Braun, T., Nicklin, S. A., Cameron, E., Loughrey, C. M., Martin, T. P. (2020) RUNX1: an emerging therapeutic target for cardiovascular disease. Cardiovascular Research, 116, pp. 1410-1423. (doi: 10.1093/cvr/cvaa034)

Williams, J. J.L., Baillie, G. S., Palmer, T. M. (2020) Investigation of Novel Cavin-1/Suppressor of Cytokine Signaling 3 (SOCS3) Interactions by Coimmunoprecipitation, Peptide Pull-Down, and Peptide Array Overlay Approaches. Springer

Gök, C., Plain, F., Robertson, A., Howie, J., Baillie, G. S., Fraser, N. J., Fuller, W. (2020) Dynamic palmitoylation of the sodium-calcium exchanger modulates its structure, affinity for lipid ordered domains, and inhibition by XIP. Cell Reports, 31, (doi: 10.1016/j.celrep.2020.107697)

Ling, J., Blair, C. M., Baillie, G. S. (2020) Fibrin Breakdown Assay. Bio-Protocol, 10, (doi: 10.21769/BioProtoc.3585)

Nosalski, R., Siedlinski, M., Denby, L., Mcginnigle, E., Nowak, M., Nguyen Dinh Cat, A., Medina-Ruiz, L., Cantini, M., Skiba, D., Wilk, G., Osmenda, G., Rodor, J., Salmeron-Sanchez, M., Graham, G., Maffia, P., Graham, D., Baker, A. H., Guzik, T. J. (2020) T cell-derived miRNA-214 mediates perivascular fibrosis in hypertension. Circulation Research, 126, pp. 988-1003. (doi: 10.1161/CIRCRESAHA.119.315428)

Blair, C. M., Ling, J., Baillie, G. S. (2020) Measuring cAMP specific phosphodiesterase activity: a two-step radioassay. Bio-Protocol, 10, (doi: 10.21769/BioProtoc.3581)

Frazier, S., McBride, M. W., Mulvana, H., Graham, D. (2020) From animal models to patients: the role of placental microRNAs, miR-210, miR-126, and miR-148a/152 in preeclampsia. Clinical Science, 134, pp. 1001-1025. (doi: 10.1042/CS20200023)

MacDonald, E. A., Rose, R. A., Quinn, T. A. (2020) Neurohumoral control of sinoatrial node activity and heart rate: insight from experimental models and findings from humans. Frontiers in Physiology, 11, (doi: 10.3389/fphys.2020.00170)

Jarvie, E., Stewart, F., Ramsay, J. E., Brown, E. A., Meyer, B., Olivecrona, G., Griffin, B., Freeman, D. (2020) Maternal adipose tissue expansion, a missing link in the prediction of birth weight centile. Journal of Clinical Endocrinology and Metabolism, 105, pp. e814-e825. (doi: 10.1210/clinem/dgz248)

Lochhead, M. R., Brown, A. D., Kirlin, A. C., Chitayat, S., Munro, K., Findlay, J. E., Baillie, G. S., LeBrun, D. P., Langelaan, D. N., Smith, S. P. (2020) Structural insights into TAZ2 domain-mediated CBP/p300 recruitment by transactivation domain 1 of the lymphopoietic transcription factor E2A. Journal of Biological Chemistry, 27, pp. 4303-4315. (doi: 10.1074/jbc.RA119.011078)

McQueen, A., Kennedy, S., McCormick, C., Aggarwal, A., McGinty, S. (2020) Mathematical Modelling of the Effect of Drug on Smooth Muscle Cell Proliferation.

Tejeda, G. S., Whiteley, E. L., Deeb, T. Z., Bürli, R. W., Moss, S. J., Sheridan, E., Brandon, N. J., Baillie, G. S. (2020) Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme. Proceedings of the National Academy of Sciences of the United States of America, 117, pp. 677-688. (doi: 10.1073/pnas.1916398117)

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Tibbo, A. J., Tejeda, G. S., Baillie, G. S. (2019) Understanding PDE4's function in Alzheimer's disease; a target for novel therapeutic approaches. Biochemical Society Transactions, 47, pp. 1557-1565. (doi: 10.1042/BST20190763)

Gatseva, A., Sin, Y. Y., Brezzo, G., Van Agtmael, T. (2019) Basement membrane collagens and disease mechanisms. Essays in Biochemistry, 63, pp. 297-312. (doi: 10.1042/EBC20180071)

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Garcia Cordoba, C., Daly, C. J. (2019) The organisation of vascular smooth muscle cells; a quantitative Fast Fourier Transform (FFT) based assessment. Translational Research in Anatomy, 16, (doi: 10.1016/j.tria.2019.100047)

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Omar, F., Findlay, J. E., Carfray, G., Allcock, R. W., Jiang, Z., Moore, C., Muir, A. L., Lannoy, M., Fertig, B. A., Maie, D., Day, J. P., Bolger, G., Baillie, G. S., Schwiebert, E., Klussmann, E., Pyne, N. J., Ong, A. C.M., Bowers, K., Adam, J. M., Adams, D. R., Houslay, M. D., Hendersona, D. J.P. (2019) Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases. Proceedings of the National Academy of Sciences of the United States of America, 116, pp. 13320-13329. (doi: 10.1073/pnas.1822113116)

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Houslay, K.F., Fertig, B.A., Christian, F., Tibbo, A.J., Ling, J., Findlay, J.E., Houslay, M.D., Baillie, G.S. (2019) Phosphorylation of PDE4A5 by MAPKAPK2 attenuates fibrin degradation via p75 signalling. Journal of Biochemistry, 166, pp. 97-106. (doi: 10.1093/jb/mvz016)

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Clister, T., Greenwald, E. C., Baillie, G. S., Zhang, J. (2019) AKAP95 organizes a nuclear microdomain to control local cAMP for regulating nuclear PKA. Cell Chemical Biology, 26, pp. 885-891. (doi: 10.1016/j.chembiol.2019.03.003)

McKittrick, C., McKee, S., Kennedy, S., Oldroyd, K., Wheel, M., Pontrelli, G., Dixon, S., Mcginty, S., McCormick, C. (2019) Combining mathematical modelling with in vitro experiments to predict in vivo drug-eluting stent performance. Journal of Controlled Release, 303, pp. 151-161. (doi: 10.1016/j.jconrel.2019.03.012)

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Mikolajczyk, T. P., Nosalski, R., Skiba, D. S., Koziol, J., Mazur, M., Justo Junior, A. S., Kowalczyk, P., Kusmierczyk, Z., Schramm Luc, A., Luc, K., Maffia, P., Graham, D., Kiss, A. K., Naruszewicz, M., Guzik, T. J. (2019) 1,2,3,4,6 penta-O -galloyl-β-D-glucose modulates perivascular inflammation and prevents vascular dysfunction in angiotensin II-induced hypertension. British Journal of Pharmacology, 176, pp. 1951-1965. (doi: 10.1111/bph.14583)

Bagot, C.N., Leishman, E., Onyiaodike, C.C., Jordan, F., Gibson, V.B., Freeman, D.J. (2019) Changes in laboratory markers of thrombotic risk early in the first trimester of pregnancy may be linked to an increase in estradiol and progesterone. Thrombosis Research, 178, pp. 47-53. (doi: 10.1016/j.thromres.2019.03.015)

Daly, C. J. (2019) From confocal microscope to virtual reality and computer games; technical and educational considerations. Infocus Magazine, 54, pp. 51-59.

Kinch, K., Fullerton, J. L., Stewart, W. (2019) One-hundred years (and counting) of blast-associated traumatic brain injury. Journal of the Royal Army Medical Corps, 165, pp. 180-182. (doi: 10.1136/jramc-2017-000867)

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Vagena, E., Ryu, J. K., Baeza-Raja, B., Walsh, N. M., Syme, C., Day, J. P., Houslay, M., Baillie, G. (2019) A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signalling. Translational Psychiatry, 9, (doi: 10.1038/s41398-019-0470-1)

Olson, E., Pravenec, M., Landa, V., Koh-Tan, H. H. C., Dominiczak, A. F., McBride, M. W., Graham, D. (2019) Transgenic overexpression of glutathione S-transferase μ-type 1 reduces hypertension and oxidative stress in the stroke-prone spontaneously hypertensive rat. Journal of Hypertension, 37, pp. 985-996. (doi: 10.1097/HJH.0000000000001960)

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Kennedy, S., Touyz, R. M. (2019) Anatomy and pharmacology of vessels. Springer

Daly, C. J. (2019) Autonomic innervation of visceral and peri-vascular adipose tissue. Editora UFPE

Daly, C. J. (2019) Examining vascular structure and function using confocal microscopy and 3D imaging techniques. Springer

Daly, C. J. (2019) Imaging the vascular wall: from microscope to virtual reality. Springer

Tibbo, A. J., Busiau, T., Baillie, G. S. (2019) Methods to investigate arrestins in complex with phosphodiesterases. Springer

Logue, J., Sattar, N., Freeman, D. (2019) Obesity. Springer

Blair, C. M., Walsh, N., Littman, B. H., Marcoux, F. W., Baillie, G. S. (2019) Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A – C-Raf. BMC Cancer, 19, (doi: 10.1186/s12885-019-5489-4)

Graham, D. (2019) Vascular physiology. Springer


Strembitska, A., Mancini, S. J., Gamwell, J. M., Palmer, T. M., Baillie, G. S., Salt, I. P. (2018) A769662 inhibits insulin-stimulated Akt activation in human macrovascular endothelial cells independent of AMP-activated protein kinase. International Journal of Molecular Sciences, 19, (doi: 10.3390/ijms19123886)

Maziarz, M., Broselid, S., DiGiacomo, V., Park, J.-C., Luebbers, A., Garcia-Navarrete, L., Blanco-Canosa, J. B., Baillie, G. S., Garcia-Marcos, M. (2018) A biochemical and genetic discovery pipeline identifies PLCδ4b as a non-receptor activator of heterotrimeric G proteins. Journal of Biological Chemistry, 293, pp. 16964-16983. (doi: 10.1074/jbc.RA118.003580)

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Elliott, C., Rojo, A. I., Ribe, E., Broadstock, M., Xia, W., Morin, P., Semenov, M., Baillie, G., Cuadrado, A., Al-Shawi, R., Ballard, C. G., Simons, P., Killick, R. (2018) A role for APP in Wnt signalling links synapse loss with β-amyloid production. Translational Psychiatry, 8, (doi: 10.1038/s41398-018-0231-6)

Engelhardt, B., Holze, J., Elliott, C., Baillie, G.S., Kschischo, M., Fröhlich, H. (2018) Modelling and mathematical analysis of the M2 receptor-dependent joint signalling and secondary messenger network in CHO cells. Mathematical Medicine and Biology, 35, pp. 279-297. (doi: 10.1093/imammb/dqx003)

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Daly, J. P., Whiteley, E., Freeley, M., Long, A., Malacrida, B., Kiely, P., Baillie, G. S. (2018) RAB40C regulates RACK1 stability via the ubiquitin-proteasome system. Future Science OA, 4, (doi: 10.4155/fsoa-2018-0022)

van Strijp, D., de Witz, C., Vos, P. C., den Biezen, E., van Brussel, A., Wrobel, J., Baillie, G. S., Tennstedt, P., Schlomm, T., Heitkötter, B., Huss, S., Bögemann, M., Houslay, M. D., Bangma, C. H., Semjonow, A., Hoffmann, R. (2018) The prognostic PDE4D7 score in a diagnostic biopsy prostate cancer patient cohort with longitudinal biological outcomes. Prostate Cancer, 2018, (doi: 10.1155/2018/5821616)

Rajani, R. M., Quick, S., Ruigrok, S. R., Graham, D., Harris, S. E., Verhaaren, B. F.J., Fornage, M., Seshadri, S., Atanur, S. S., Dominiczak, A. F., Smith, C., Wardlaw, J. M., Williams, A. (2018) Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats. Science Translational Medicine, 10, (doi: 10.1126/scitranslmed.aam9507)

Daly, C. J. (2018) The future of education? Using 3D animation and virtual reality in teaching physiology. Physiology News, 111, pp. 43.

Morgan, H. L., Butler, E., Ritchie, S., Herse, F., Dechend, R., Beattie, E., McBride, M. W., Graham, D. (2018) Modeling superimposed preeclampsia using Ang II (Angiotensin II) infusion in pregnant stroke-prone spontaneously hypertensive rats. Hypertension, 72, pp. 208-218. (doi: 10.1161/HYPERTENSIONAHA.118.10935)

De Lucca Camargo, L., Harvey, A. P., Rios, F. J., Tsiropoulou, S., Silva, R. D. N. d. O., Cao, Z., Graham, D., McMaster, C., Burchmore, R. J., Hartley, R. C., Bulleid, N., Montezano, A. C., Touyz, R. M. (2018) Vascular Nox (NADPH oxidase) compartmentalization, protein hyperoxidation, and endoplasmic reticulum stress response in hypertension. Hypertension, 72, pp. 235-246. (doi: 10.1161/HYPERTENSIONAHA.118.10824)

Bailey, E., McBride, M. W., McClure, J. D., Beattie, W., Graham, D., Dominiczak, A., Smith, C., Wardlaw, J. (2018) Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease. Clinical Science, 132, pp. 1315-1328. (doi: 10.1042/CS20171572)

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Armfield, K., Baillie, G., Wilson, J.B. (2018) Development of Therapeutic Approaches to Targeting Epstein-Barr virus Related Malignancies.

de Inda, M. A., van Strijp, D., den Biezen-Timmermans, E., van Brussel, A., Wrobel, J., van Zon, H., Vos, P., Baillie, G. S., Tennstedt, P., Schlomm, T., Houslay, M. D., Bangma, C., Hoffmann, R. (2018) Validation of cyclic adenosine monophosphate phosphodiesterase-4D7 for its independent contribution to risk stratification in a prostate cancer patient cohort with longitudinal biological outcomes. European Urology Focus, 4, pp. 376-384. (doi: 10.1016/j.euf.2017.05.010)

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Mancini, S. J., Boyd, D., Katwan, O. J., Strembitska, A., Almabrouk, T. A., Kennedy, S., Palmer, T. M., Salt, I. P. (2018) Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms. Scientific Reports, 8, (doi: 10.1038/s41598-018-23420-4)

Sellers, K. J., Elliott, C., Jackson, J., Ghosh, A., Ribe, E., Rojo, A. I., Jarosz-Griffiths, H. H., Watson, I. A., Xia, W., Semenov, M., Morin, P., Hooper, N. M., Porter, R., Preston, J., Al-Shawi, R., Baillie, G., Lovestone, S., Cuadrado, A., Harte, M., Simons, P., Srivastava, D. P., Killick, R. (2018) Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil. Alzheimer's and Dementia, 14, pp. 306-317. (doi: 10.1016/j.jalz.2017.09.008)

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Fertig, B. A., Baillie, G. S. (2018) PDE4-mediated cAMP signalling. Journal of Cardiovascular Development and Disease, 5, (doi: 10.3390/jcdd5010008)

Onyiaodike, C. C., Murray, H. M., Zhang, R., Meyer, B. J., Jordan, F., Brown, E. A., Nibbs, R. J.B., Lyall, H., Sattar, N., Nelson, S. M., Freeman, D. J. (2018) Pre-conception maternal erythrocyte saturated to unsaturated fatty acid ratio predicts pregnancy after natural cycle frozen embryo transfer. Scientific Reports, 8, (doi: 10.1038/s41598-018-19500-0)

Williams, J. J.L., Al-Otaiq, N., Mullen, W., Burchmore, R., Liu, L., Baillie, G. S., Schaper, F., Pilch, P. F., Palmer, T. M. (2018) Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability. Nature Communications, 9, (doi: 10.1038/s41467-017-02585-y)

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Basole, C. P., Nguyen, R. K., Lamothe, K., Vang, A., Clark, R., Baillie, G. S., Epstein, P. M., Brocke, S. (2017) PDE8 controls CD4(+) T cell motility through the PDE8A-Raf-1 kinase signaling complex. Cellular Signalling, 40, pp. 62-72. (doi: 10.1016/j.cellsig.2017.08.007)

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Lemonidis, K., MacLeod, R., Baillie, G. S., Chamberlain, L. H. (2017) Peptide array based screening reveals a large number of proteins interacting with the ankyrin repeat domain of the zDHHC17 S-acyltransferase. Journal of Biological Chemistry, 292, pp. 17190-17202. (doi: 10.1074/jbc.M117.799650)

Almabrouk, T. A. M., Ugusman, A. B., Katwan, O. J., Salt, I. P., Kennedy, S. (2017) Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adiponectin release. British Journal of Pharmacology, 174, pp. 3398-3410. (doi: 10.1111/bph.13633)

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Jayabalan, N., Nair, S., Nuzhat, Z., Rice, G. E., Zúñiga, F. A., Sobrevia, L., Leiva, A., Sanhueza, C., Agustin Gutierrez, J., Lappas, M., Freeman, D. J., Salomon, C. (2017) Cross talk between adipose tissue and placenta in obese and gestational diabetes mellitus pregnancies via exosomes. Frontiers in Endocrinology, 8, (doi: 10.3389/fendo.2017.00239)

Wu, J., Lawrence, C., Wadsworth, R. M., Kennedy, S. (2017) Perivascular mast cells promote neointimal elastin deposition and suppress chronic vein graft restenosis in hyperlipidaemic mice. Vessel Plus, 2017, pp. 137-144. (doi: 10.20517/2574-1209.2017.15)

Bagot, C.N., Leishman, E., Onyiaodike, C.C., Jordan, F., Freeman, D.J. (2017) Normal pregnancy is associated with an increase in thrombin generation from the very early stages of the first trimester. Thrombosis Research, 157, pp. 49-54. (doi: 10.1016/j.thromres.2017.06.027)

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Nishi, K., Luo, H., Ishikura, S., Doi, K., Iwaihara, Y., Wills, L., Baillie, G. S., Sakata, T., Shirasawa, S., Tsunoda, T. (2017) Apremilast induces apoptosis of human colorectal cancer cells with mutant KRAS. Anticancer Research, 37, pp. 3833-3839. (doi: 10.21873/anticanres.11762)

Kiely, M., Adams, D. R., Hayes, S. L., O'Connor, R., Baillie, G. S., Kiely, P. A. (2017) RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells. Cellular Signalling, 35, pp. 290-300. (doi: 10.1016/j.cellsig.2016.09.001)

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Diamantopoulou, Z., White, G., Fadlullah, M. Z.H., Dreger, M., Pickering, K., Maltas, J., Ashton, G., MacLeod, R., Baillie, G. S., Kouskoff, V., Lacaud, G., Murray, G. I., Sansom, O. J., Hurlstone, A. F.L., Malliri, A. (2017) TIAM1 antagonizes TAZ/YAP both in the destruction complex in the cytoplasm and in the nucleus to inhibit invasion of intestinal epithelial cells. Cancer Cell, 31, pp. 621-634. (doi: 10.1016/j.ccell.2017.03.007)

Monterisi, S., Lobo, M. J., Livie, C., Castle, J. C., Weinberger, M., Baillie, G., Surdo, N. C., Musheshe, N., Stangherlin, A., Gottlieb, E., Maizels, R., Bortolozzi, M., Micaroni, M., Zaccolo, M. (2017) PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling. eLife, 6, (doi: 10.7554/eLife.21374)

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Schoenherr, C., Byron, A., Sandilands, E., Paliashvili, K., Baillie, G. S., Valacca, C., Cecconi, F., Serrels, B., Frame, M. C. (2017) Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks. eLife, 6, (doi: 10.7554/eLife.23172)

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Houslay, K. F., Christian, F., MacLeod, R., Adams, D. R., Houslay, M. D., Baillie, G. S. (2017) Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners. Biochemical Journal, 474, pp. 597-609. (doi: 10.1042/BCJ20160849)

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Deschamps, T., Quentin, B., Leske, D. M., MacLeod, R., Mompelat, D., Tafforeau, L., Lotteau, V., Maréchal, V., Baillie, G. S., Gruffat, H., Wilson, J. B., Manet, E. (2017) Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle. Journal of General Virology, 98, pp. 251-265. (doi: 10.1099/jgv.0.000681)

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Cameron, R. T., Whiteley, E., Day, J. P., Parachikova, A. I., Baillie, G. S. (2017) Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1-42 mediated cytotoxicity. FEBS Open Bio, 7, pp. 64-73. (doi: 10.1002/2211-5463.12156)

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Javadi, A., Deevi, R. K., Evergren, E., Blondel-Tepaz, E., Baillie, G. S., Scott, M. G.H., Campbell, F. C. (2017) PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex. eLife, 6, (doi: 10.7554/eLife.24578)


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Böttcher, R., Dulla, K., van Strijp, D., Dits, N., Verhoef, E. I., Baillie, G. S., Van Leenders, G. J.L.H., Houslay, M. D., Jenster, G., Hoffmann, R. (2016) Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and development of distant metastases. Oncotarget, 7, pp. 70669-70684. (doi: 10.18632/oncotarget.12204)

Yun, S., Budatha, M., Dahlman, J. E., Coon, B. G., Cameron, R. T., Langer, R., Anderson, D. G., Baillie, G., Schwartz, M. A. (2016) Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling. Nature Cell Biology, 18, pp. 1043-1053. (doi: 10.1038/ncb3405)

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Morgan, H., Small, H.Y., Beattie, E., McBride, M.W., Graham, D. (2016) [OP.5D.02] Transcriptomic changes in early pregnancy-associated uterine artery remodelling in stroke prone spontaneously hypertensive rat. Journal of Hypertension, 34, pp. e63-e63. (doi: 10.1097/01.hjh.0000491501.79443.05)

Havekes, R., Park, A. J., Tolentino, R. E., Bruinenberg, V. M., Tudor, J. C., Lee, Y., Hansen, R. T., Guercio, L. A., Linton, E., Neves, S. R., Meerlo, P., Baillie, G. W., Houslay, M. D., Abel, T. (2016) Compartmentalized PDE4A5 signaling impairs hippocampal synaptic plasticity and long-term memory. Journal of Neuroscience, 36, pp. 8936-8946. (doi: 10.1523/JNEUROSCI.0248-16.2016)

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MacRitchie, N., Volpert, G., Al Washih, M., Watson, D. G., Futerman, A. H., Kennedy, S., Pyne, S., Pyne, N. J. (2016) Effect of the sphingosine kinase 1 selective inhibitor, PF-543 on arterial and cardiac remodelling in a hypoxic model of pulmonary arterial hypertension. Cellular Signalling, 28, pp. 946-955. (doi: 10.1016/j.cellsig.2016.03.014)

Roscoe, R. B., Elliott, C., Zarros, A., Baillie, G. S. (2016) Non-genetic therapeutic approaches to Canavan disease. Journal of the Neurological Sciences, 366, pp. 116-124. (doi: 10.1016/j.jns.2016.05.012)

Bachmann, V. A., Mayrhofer, J. E., Ilouz, R., Tschaikner, P. M., Raffeiner, P., Röck, R., Courcelles, M., Lu, T.-W., Baillie, G. S., Thibault, P., Aanstad, P., Stelzl, U., Taylor, S. S., Stefan, E. (2016) GPR61 anchoring of PKA consolidates GPCR and cAMP signaling. Proceedings of the National Academy of Sciences of the United States of America, 113, pp. 7786-7791. (doi: 10.1073/pnas.1608061113)

Baillie, G. S. (2016) Editorial. Cellular Signalling, 28, pp. 699-700. (doi: 10.1016/j.cellsig.2016.02.001)

Wills, L., Ehsan, M., Whiteley, E. L., Baillie, G. S. (2016) Location, location, location: PDE4D5 function is directed by its unique N-terminal region. Cellular Signalling, 28, pp. 701-705. (doi: 10.1016/j.cellsig.2016.01.008)

Daly, C., Bulloch, J., Aidulis, D., Ma, M. (2016) The Design of Animations and Multimedia for Teaching.

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McCormick, C., Jones, R. L., Wadsworth, R. M., Mullen, A. B., Kennedy, S. (2016) A polymer coated cicaprost-eluting stent increases neointima formation and impairs vessel function in the rabbit iliac artery. Pharmacology and Pharmacy, 7, pp. 226-235. (doi: 10.4236/pp.2016.76029)

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Jones, F. E., Bailey, M. A., Murray, L. S., Lu, Y., McNeilly, S., Schlötzer-Schrehardt, U., Lennon, R., Sado, Y., Brownstein, D. G., Mullins, J. J., Kadler, K. E., Van Agtmael, T. (2016) ER stress and basement membrane defects combine to cause glomerular and tubular renal disease resulting from Col4a1 mutations in mice. Disease Models and Mechanisms, 9, pp. 165-76. (doi: 10.1242/dmm.021741)

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Dachtler, J., Elliott, C., Rodgers, R. J., Baillie, G. S., Clapcote, S. J. (2016) Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice. Scientific Reports, 6, (doi: 10.1038/srep18748)

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Meyer, B. J., Onyiaodike, C. C., Brown, E. A., Jordan, F., Murray, H., Nibbs, R. J. B., Sattar, N., Lyall, H., Nelson, S. M., Freeman, D. J. (2016) Maternal plasma DHA levels increase prior to 29 days post-LH surge in women undergoing frozen embryo transfer: a prospective, observational study of human pregnancy. Journal of Clinical Endocrinology and Metabolism, 101, pp. 1745-1753. (doi: 10.1210/jc.2015-3089)

Tankou, S., Ishii, K., Elliott, C., Yalla, K., Kubo, K.-i., Brandon, N. J., Tang, Q., Hayward, G., Nakajima, K., Houslay, M., Kamiya, A., Baillie, G., Ishizuka, K., Sawa, A. (2016) SUMOylation of DISC1: a potential role in neural progenitor proliferation in the developing cortex. Molecular Neuropsychiatry, 2, pp. 20-27. (doi: 10.1159/000444257)

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Baillie, G. S. (2015) George Baillie on peptide array, a technique that transformed research on phosphodiesterases. Future Science OA, 1, (doi: 10.4155/fso.15.25)

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MacLeod, R., Hillert, E.-K., Cameron, R. T., Baillie, G. S. (2015) The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease. Future Science OA, 1, (doi: 10.4155/fso.15.9)

Akehurst, C., Small, H., Sharafetdinova, L., Forrest, R., Beattie, W., Brown, C. E., Robinson, S. W., McClure, J. D., Work, L. M., Carty, D. M., McBride, M. W., Freeman, D. J., Delles, C. (2015) Differential expression of microRNA-206 and its target genes in pre-eclampsia. Journal of Hypertension, 33, pp. 2068-2074. (doi: 10.1097/HJH.0000000000000656)

Sin, Y. Y., Baillie, G. (2015) Heat Shock Protein 20 (HSP20) is a novel substrate for Protein Kinase D1 (PKD1) Cell Biochemistry and Function, 33, pp. 421-426. (doi: 10.1002/cbf.3147)

Zoccarato, A. et al. (2015) Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2. Circulation Research, 117, pp. 707-719. (doi: 10.1161/CIRCRESAHA.114.305892)

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Zarros, A., Cameron, R.T., Bimpis, A., Baillie, G.S. (2015) Exposure of mHIPPOE-14 cells to oligomycin as a tool for in vitro approaches to brain ischaemia-related pro- and epiphenomena: time-dependent cellular response profiling. Atherosclerosis, 241, pp. e221. (doi: 10.1016/j.atherosclerosis.2015.04.1038)

Parnell, E., Koschinski, A., Zaccolo, M., Cameron, R. T., Baillie, G. S., Baillie, G. L., Porter, A., McElroy, S. P., Yarwood, S. J. (2015) Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells. Biochimica et Biophysica Acta: Molecular Cell Research, 1853, pp. 1749-1758. (doi: 10.1016/j.bbamcr.2015.04.009)

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Wang, L., Burmeister, B. T., Johnson, K. R., Baillie, G. S., Karginov, A. V., Skidgel, R. A., O'Bryan, J. P., Carnegie, G. K. (2015) UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy. Cellular Signalling, 27, pp. 908-922. (doi: 10.1016/j.cellsig.2015.02.003)

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Bolger, G. B., Dunlop, A. J., Meng, D., Day, J. P., Klussmann, E., Baillie, G. S., Adams, D. R., Houslay, M. D. (2015) Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains. Cellular Signalling, 27, pp. 756-769. (doi: 10.1016/j.cellsig.2014.12.009)

Sin, Y. Y., Martin, T. P., Wills, L., Currie, S., Baillie, G. S. (2015) Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy. Cell Communication and Signaling, 13, (doi: 10.1186/s12964-015-0094-x)

Rannikmäe, K. et al. (2015) Common variation in COL4A1/COL4A2 is associated with sporadic cerebral small vessel disease. Neurology, 84, pp. 918-926. (doi: 10.1212/WNL.0000000000001309)

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Zarros, A., Johnson, S. A., Mackenzie-Gray Scott, C. A., Baillie, G. S. (2015) Cytodynamics and endpoint selection for a reliable in vitro assessment of nanoneurotoxicity. Nanomedicine: Nanotechnology, Biology and Medicine, 11, pp. 407-408. (doi: 10.1016/j.nano.2014.08.014)

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It is now apparent that adipose tissue is highly heterogenous and plastic, exhibiting depot-specific functions regulated by multiple mechanisms that are not fully characterised and understood. There is increasing interest in the (patho)physiological roles of inflammatory, immunometabolic, adipogenic and “beiging” pathways within adipose tissue as these represent potential therapeutic targets to aid with weight loss and address pathophysiological consequences of adipose tissue dysfunction. Furthermore, determining the mechanisms by which adipose influences other tissues and how variables such as sex, age, deprivation and ethnicity impact on these is necessary.

Ongoing research topics include:

  • Adipocyte function and differentiation in South Asians and sepsis.
  • Ectopic fat, adipose tissue fibrosis, adipocyte differentiation, lipid metabolism in pregnancy, and its metabolic complications (gestational diabetes mellitus and pre-eclampsia).
  • The role of insulin signalling in vascular tissues.
  • The role of AMP-activated protein kinase as a regulator of metabolic health.
  • The role of asymmetric dimethylarginine in metabolic tissue function.

We will characterise the molecular and cellular mechanisms by which altered adipose tissue function and ectopic fat contribute to metabolic disease. Therefore this research will contribute to identifying novel mechanisms regulating adipose tissue function and potential therapeutic targets for obesity and related pathophysiology across the lifecourse.