Hypertension
We study all aspects of hypertension (high blood pressure) from understanding the pathophysiology to describing the epidemiology and developing new potential treatments.
Staff
Publications
2024
Reddin, C., Canavan, M., Hankey, G. J., Oveisgharan, S., Langhorne, P., Wang, X., Iversen, H. K., Lanas, F., Al-Hussain, F., Czlonkowska, A., Oğuz, A., Judge, C., Rosengren, A., Xavier, D., Yusuf, S., O'Donnell, M. (2024) Association of vascular risk with severe vs non-severe stroke: an analysis of the INTERSTROKE study. Neurology, 103, (doi: 10.1212/wnl.0000000000210087)
Montezano, A. C., Kuriakose, J., Hood, K. Y., Sin, Y. Y., Camargo, L. L., Namkung, Y., Castro, C. H., Santos, R. A., Alves-Lopes, R., Tejeda, G., Passaglia, P., Basheer, S., Gallen, E., Findlay, J. E., Awan, F. R., Laporte, S. A., MacLean, M. R., Baillie, G. S., Touyz, R. M. (2024) Ang-(1-7) and ET-1 interplay through Mas and ETB receptor interaction defines a novel vasoprotective mechanism. Hypertension, (doi: 10.1161/HYPERTENSIONAHA.124.22693)
Greenlees, C., Hosseinzadeh, S., Delles, C., Mcginnigle, E. (2024) Hypertension evaluation and management in new young patients: are we doing our female patients a disservice? Blood Pressure, 33, (doi: 10.1080/08037051.2024.2387909)
Ang, D. T.Y., Carberry, J., Ford, T. J., Kamdar, A., Sykes, R., Sidik, N. P., Carrick, D., McCartney, P. J., Collison, D., Robertson, K., Shaukat, A., Rocchiccioli, J. P., McGeoch, R., Watkins, S., Hood, S., McEntegart, M., Lindsay, M., Eteiba, H., Oldroyd, K. G., Good, R., McConnachie, A., Berry, C. (2024) Coronary microvascular function and atherosclerotic plaque burden in ischaemia and no obstructive coronary arteries: a secondary analysis of the CorMicA trial. Heart, (doi: 10.1136/heartjnl-2024-324677)
McGinley, K. A., Lucas-Herald, A., Connelly, P., Delles, C. (2024) Gender-affirming hormone therapy: effects on cardiovascular risk and vascular function. Endocrine Connections, (doi: 10.1530/EC-24-0222)
Delles, C., Schmieder, R. E., Daly, R., Kannenkeril, D., Bosch, A., Lauder, L., Kunz, M., Böhm, M., Hamilton, G., Schmieder, R. S., Schmid, A., Herzyk, P., Mahfoud, F. (2024) Response of blood pressure to renal denervation is not associated with genetic variants. Hypertension, (doi: 10.1161/HYPERTENSIONAHA.124.23393)
Fullerton, J. L., Hay, J., Bryant-Craig, C., Atkinson, J., Smith, D. H., Stewart, W. (2024) Pediatric traumatic brain injury and microvascular blood-brain barrier pathology. JAMA Network Open, 7, (doi: 10.1001/jamanetworkopen.2024.46767)
Main, A., Mary, S., Sin, Y. Y., Wright, T. A., Ling, J., Blair, C. M., Smith, G. L., Fuller, W., Baillie, G. S. (2024) SUMOylation of cardiac myosin binding protein-C reduces its phosphorylation and results in impaired relaxation following treatment with isoprenaline. International Journal of Biochemistry and Cell Biology, 176, (doi: 10.1016/j.biocel.2024.106668)
Dieden, A., Girerd, N., Ottosson, F., Molvin, J., Pareek, M., Melander, O., Bachus, E., Råstam, L., Lindblad, U., Daka, B., Leósdóttir, M., Nilsson, P. M., Olsen, M. H., Clark, A. L., Cleland, J. G.F., Delles, C., González, A., Lamiral, Z., Duarte, K., Rossignol, P., Zannad, F., Gudmundsson, P., Jujić, A., Magnusson, M. (2024) Proteomic biomarkers and pathway analysis for progression to heart failure in three epidemiological representative cohorts. European Journal of Heart Failure, (doi: 10.1002/ejhf.3502)
Foley, P.W., Kalra, P.R., Cleland, J.G.F., Petrie, M.C., Kalra, P.A., Squire, I., Campbell, P., Chapman, C., Donnelly, P., Graham, F., Hannah, A., Lang, N.N., Matthews, I., Leslie, S.J., Pellicori, P., Piper, S., Ray, R., Savage, H.O., Spencer, C., Walsh, J., Wong, Y., Ford, I. (2024) Effect of correcting iron deficiency on the risk of serious infection in heart failure insights from the IRONMAN trial. European Journal of Heart Failure, (doi: 10.1002/ejhf.3504)
Riddell, A., Flynn, A., Bergugnat, H., Dowsett, L. B., Miller, A. A. (2024) SDMA as a marker and mediator in cerebrovascular disease. Clinical Science, 138, pp. 1305-1323. (doi: 10.1042/CS20241021)
Ho, F., Allan, M., Shao, H., Man, K. K.C., Jani, B. D., Lyall, D., Hastie, C., Fleming, M., Mackay, D., Cleland, J. G.F., Delles, C., Dundas, R., Lewsey, J., Ip, P., Wong, I., Welsh, P., Pearce, A., Wright, C. M., Minnis, H., Katikireddi, V., Pell, J. P. (2024) Maternal and pregnancy factors contributing to the association between area deprivation and infant mortality in England: a retrospective cohort study. Lancet Regional Health - Europe, (doi: 10.1016/j.lanepe.2024.101075)
Lee, M., Petrie, M. C., Cleland, J. G.F., Donnelly, P., Francis, M., Hannah, A., Japp, A. G., Labinjoh, C., Lang, N. N., Mainsty, C., Petrie, C. J., Piper, S. E., Williams, S. G., Ford, I., Kalra, P. R., IRONMAN Trial Investigators, (2024) Administration of ferric derisomaltose for iron deficiency and heart failure during hospital admission or at the clinic – insights from the IRONMAN trial. European Journal of Heart Failure, 26, pp. 2293-2295. (doi: 10.1002/ejhf.3394)
McCallum, L., Lip, S., McConnachie, A., Brooksbank, K., MacIntyre, I., Doney, A., Llano, A., Aman, A., Caparrotta, T. M., Ingram, G., Mackenzie, I. S., Dominiczak, A. F., MacDonald, T. M., Webb, D. J., Padmanabhan, S. (2024) UMOD genotype-dependent effects of Torasemide on ambulatory blood pressure: a multicentre genotype-blinded trial. Hypertension, 81, pp. 2049-2059. (doi: 10.1161/HYPERTENSIONAHA.124.23122)
Beazer, J. D., Sillars, A., Beck, S., Christoffersen, C., Ferraz, M. J., Mulder, M., Graham, D., Karlsson, H., Ljunggren, S. A., Gill, J. M. R., Freeman, D. J. (2024) Favourable HDL composition in endurance athletes is not associated with changes in HDL in vitro antioxidant and endothelial anti-inflammatory function. Bioscience Reports, (doi: 10.1042/BSR20241165)
Zhou, M., Mary, S., Delles, C., Padmanabhan, S., Graham, D., McBride, M. W., Dominiczak, A. (2024) Insights into uromodulin and blood pressure. Current Hypertension Reports, (doi: 10.1007/s11906-024-01317-0)
Morrow, A. et al. (2024) Zibotentan in microvascular angina: a randomized, placebo-controlled, crossover trial. Circulation, (doi: 10.1161/CIRCULATIONAHA.124.069901)
McNeilly, S. et al. (2024) Collagen IV deficiency causes hypertrophic remodeling and endothelium-dependent hyperpolarization in small vessel disease with intracerebral hemorrhage. EBioMedicine, 107, (doi: 10.1016/j.ebiom.2024.105315)
Lipina, T., Li, S., Petrova, E. S., Amstislavskaya, T. G., Cameron, R. T., Elliott, C., Gondo, Y., McGirr, A., Mullins, J. G.L., Baillie, G. S., Woodgett, J. R., Clapcote, S. J. (2024) PDE4B missense variant increases susceptibility to post-traumatic stress disorder-relevant phenotypes in mice. Journal of Neuroscience,
McLaren, J., Gao, X., Ghouri, N., Freeman, D. J., Richardson, J., Sattar, N., Gill, J. M.R. (2024) Weight gain leads to greater adverse metabolic responses in South Asian compared with white European men: the GlasVEGAS study. Nature Metabolism, 6, pp. 1632-1645. (doi: 10.1038/s42255-024-01101-z)
Thongyim, S., Wright, T. A., Sattayawat, P., Kaewkod, T., Baillie, G. S., Tragoolpua, Y., Jangsutthivorawat, S., Panya, A. (2024) Clinacanthus nutans extract lowers periodontal inflammation under high-glucose conditions via inhibiting NF-κB signaling pathway. Frontiers in Pharmacology, 15, (doi: 10.3389/fphar.2024.1410419)
Elyan, B. M.P., Sullivan, M. K., Hedley, J., De La Mata, N., Webster, A. C., Venugopal, B., Jones, R. J., Lang, N. N., Mark, P. B., Lees, J. S. (2024) The impact of VEGF signalling pathway inhibitors and/or immune checkpoint inhibitors on kidney function over time: a single centre retrospective analysis. BJC Reports, 2, (doi: 10.1038/s44276-024-00081-7)
Richardson, S. H., Mackenzie, J., Thekkethil, N., Feng, L., Lee, J., Berry, C., Hill, N., Luo, X., Gao, H. (2024) Cardiac perfusion coupled with a structured coronary network tree. Computer Methods in Applied Mechanics and Engineering, 428, (doi: 10.1016/j.cma.2024.117083)
Carberry, J., Petrie, M. C., Lee, M. M.Y., Brooksbank, K., Campbell, R. T., Good, R., Jhund, P. S., Kellman, P., Lang, N. N., Mangion, K., Mark, P. B., McConnachie, A., McMurray, J. J.V., Meyer, B., Orchard, V., Shaukat, A., Watkins, S., Welsh, P., Sattar, N., Berry, C., Docherty, K. F. (2024) Empagliflozin to prevent progressive adverse remodelling after myocardial infarction (EMPRESS-MI): rationale and design. ESC Heart Failure, 11, pp. 2001-2012. (doi: 10.1002/ehf2.14830)
Docherty, K. F., McMurray, J. J.V., Kalra, P., Cleland, J. G.F., Lang, N. N., Petrie, M. C., Robertson, M., Ford, I. (2024) Intravenous iron and SGLT2 inhibitors in iron-deficient patients with heart failure and reduced ejection fraction. ESC Heart Failure, 11, pp. 1875-1879. (doi: 10.1002/ehf2.14742)
Murphy, R. P., Hankey, G. J., Judge, C., Reddin, C., Langhorne, P., López-Jaramillo, P., Mondo, C., Xavier, D., Wang, X., Yusuf, S., O'Donnell, M. (2024) Markers of periodontal disease and risk of stroke: INTERSTROKE case-control study. Journal of Stroke and Cerebrovascular Diseases, 33, (doi: 10.1016/j.jstrokecerebrovasdis.2024.107803)
Li, C., Wu, J., Lin, J., Wu, Y., Xu, R., Quian, J., Hau, W. K., Barbato, E., Johnson, N. J., Hennigan, B., Berry, C., Oldroyd, K. G., Song, L., Ge, J. (2024) Validation of a new non-hyperemic physiological index: the constant-resistance ratio (cRR) Journal of Invasive Cardiology, 36, (doi: 10.25270/jic/24.00047)
Delles, C., Setjiadi, D., Geddes, C. (2024) Blood pressure measurement technique in clinical practice. Research Square, (doi: 10.21203/rs.3.rs-4635130/v1)
Shead, K. D., Huethorst, E., Burton, F., Lang, N., Myles, R. C., Smith, G. L. (2024) Human induced pluripotent stem cell derived cardiomyocytes for pre-clinical cardiotoxicity screening. JACC: CardioOncology,
Kelham, M., Vyas, R., Ramaseshan, R., Rathod, K., de Winter, R. J., de Winter, R. W., Bendz, B., Thiele, H., Hirlekar, G., Morici, N., Myat, A., Michalis, L. K., Sanchis, J., Kunadian, V., Berry, C., Mathur, A., Jones, D. A. (2024) Non-ST-elevation acute coronary syndromes with previous coronary artery bypass grafting: a meta-analysis of invasive vs. conservative management. European Heart Journal, 45, pp. 2380-2391. (doi: 10.1093/eurheartj/ehae245)
Berry, C., Sidik, N. P., McEntegart, M. B., CorCTA Investigators, (2024) Response by Berry et al to letter regarding article, "Invasive Endotyping in Patients With Angina and No Obstructive Coronary Artery Disease: A Randomized Controlled Trial". Circulation, 150, pp. e5-e6. (doi: 10.1161/CIRCULATIONAHA.124.069708)
Collet, C. et al. (2024) A systematic approach to the evaluation of the coronary microcirculation using bolus thermodilution: CATH CMD. Journal of the Society for Cardiovascular Angiography and Interventions, 3, (doi: 10.1016/j.jscai.2024.101934)
Sin, Y. Y., Cameron, R. T., Schepers, M., MacLeod, R., Wright, T. A., Paes, D., van den Hove, D., Willems, E., Vanmierlo, T., Prickaerts, J., Blair, C. M., Baillie, G. S. (2024) Beta-amyloid interacts with and activates the longform phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability. FEBS Letters, 598, pp. 1591-1604. (doi: 10.1002/1873-3468.14902)
Shead, K. D., Salyahetdinova, V., Baillie, G. S. (2024) Charting the importance of Filamin A posttranslational modifications. Biochemical Journal, 481, pp. 865-881. (doi: 10.1042/BCJ20240121)
Gardner, O. F.W., Bai, T., Baillie, G. S., Ferretti, P. (2024) Phosphodiesterase 4D activity in acrodysostosis-associated neural pathology: too much or too little? Brain Communications, (doi: 10.1093/braincomms/fcae225)
Kulkarni, S., Faconti, L., Partridge, S., Delles, C., Glover, M., Lewis, P., Gray, A., Hodson, E., Macintyre, I., Maniero, C., McEniery, C. M., Sinha, M. D., Walsh, S. B., Wilkinson, I. B. (2024) Investigation and management of young-onset hypertension: British and Irish Hypertension Society position statement. Journal of Human Hypertension, (doi: 10.1038/s41371-024-00922-5)
Canning, J., Strawbridge, R. J., Miedzybrodzka, Z., Marioni, R. E., Melbye, M., Porteous, D. J., Hurles, M. E., Sattar, N., Sudlow, C. L.M., Collins, R., Padmanabhan, S., Pell, J. P. (2024) Methods applied to neonatal dried blood spot samples for secondary research purposes: a scoping review. Critical Reviews in Clinical Laboratory Sciences, (doi: 10.1080/10408363.2024.2360996)
Rankin, S., Fountain, C., Gemmell, A., Quinn, D., Henderson, A., McClure, J., Small, S., Venugopal, B., McKay, P., Slomka, P. J., Colville, D., Petrie, M. C., Meléndez, G. C., Lang, N. N. (2024) Arterial effects of anthracycline: structural and inflammatory assessments in non-human primates and lymphoma patients using 18F-FDG positron emission tomography. bioRxiv, (doi: 10.1101/2024.05.30.596741)
Ang, D. T.Y., Abraham, G., Sim, K. Y.T., Sidik, N. P., Anwar, M., Ford, T. J., Berry, C., Hoole, S. P. (2024) Comparing pressure-bounded versus thermodilution-derived coronary flow reserve in unobstructed coronary arteries. American Journal of Cardiology, 222, pp. 165-166. (doi: 10.1016/j.amjcard.2024.05.014)
Tran, T. Q. B., Lip, S., du Toit, C., Kalaria, T. K., Bhaskar, R. K., O'Neil, A. Q., Graff, B., Hoffmann, M., Szyndler, A., Polonis, K., Wolf, J., Reddy, S., Narkiewicz, K., Dasgupta, I., Dominiczak, A. F., Visweswaran, S., McCallum, L., Padmanabhan, S. (2024) Assessing machine learning for diagnostic classification of hypertension types identified by ambulatory blood pressure monitoring. CJC Open, 6, pp. 798-804. (doi: 10.1016/j.cjco.2024.03.005)
Padmanabhan, S., Delles, C., Dominiczak, A. F. (2024) Beyond genome-wide scans: advancing hypertension genomics into the future. Hypertension, 81, pp. 1186-1189. (doi: 10.1161/HYPERTENSIONAHA.124.21371)
Ang, D. T.Y., Carrick, D., Kamdar, A., Sykes, R., McGeoch, R. J., Collison, D., McConnachie, A., Berry, C. (2024) Intracoronary adenosine–derived coronary flow reserve and index of microvascular resistance. Circulation: Cardiovascular Interventions, 17, (doi: 10.1161/circinterventions.123.013667)
Curtain, J. P., Talebi, A., McIntosh, A., McConnachie, A., O’Donnell, J., Welsh, P., Osmanska, J., Lee, M. M.Y., Sonecki, P., Akl, T., Seo, J., Gopinathan, V., Hurwitz, J., Thiagarajan, S., Pettit, S., Kalra, P. R., Patel, R. K., Mark, P. B., Lang, N. N., McMurray, J. J.V., Petrie, M. C., Gardner, R. S., Jhund, P. S. (2024) Measuring congestion with a non-invasive monitoring device in heart failure and haemodialysis: CONGEST-HF. European Journal of Heart Failure, 26, pp. 1383-1392. (doi: 10.1002/ejhf.3290)
Murphy, R. et al. (2024) Variations in the prevalence of atrial fibrillation, and in the strength of its association with ischemic stroke, in countries with different income levels: INTERSTROKE case–control study. International Journal of Stroke, 19, pp. 559-568. (doi: 10.1177/17474930241227783)
Docherty, N. G., Delles, C., López-Hernández, F. J. (2024) Reframing acute kidney injury as a pathophysiological continuum of disrupted renal excretory function. Acta Physiologica, (doi: 10.1111/apha.14181)
Lawson, C. A. et al. (2024) Long COVID and cardiovascular disease: a prospective cohort study. Open Heart, 11, (doi: 10.1136/openhrt-2024-002662)
Loughrey, C. et al. (2024) A novel ryanodine receptor 2 inhibitor, M201-A, enhances natriuresis, renal function and lusi-inotropic action: Pre-clinical and phase I study. British Journal of Pharmacology, 181, pp. 3401-3419. (doi: 10.1111/bph.16379)
Lechner, I., Reindl, M., Stiermaier, T., Tiller, C., Holzknecht, M., Oberhollenzer, F., von der Emde, S., Mayr, A., Feistritzer, H.-J., Carberry, J., Carrick, D., Bauer, A., Thiele, H., Berry, C., Eitel, I., Metzler, B., Reinstadler, S. J. (2024) Clinical outcomes associated with various microvascular injury patterns identified by CMR after STEMI. Journal of the American College of Cardiology, 83, pp. 2052-2062. (doi: 10.1016/j.jacc.2024.03.408)
Eerdekens, R., El Farissi, M., De Maria, G. L., van Royen, N., van ‘t Veer, M., van Leeuwen, M. A.H., Hoole, S. P., Marin, F., Carrick, D., Tonino, P. A.L., Pijls, N. H.J., Fineschi, M., Oldroyd, K. G., Berry, C., Banning, A. P., Fearon, W. F., Zimmermann, F. M. (2024) Prognostic value of microvascular resistance reserve after percutaneous coronary intervention in patients with myocardial infarction. Journal of the American College of Cardiology, 83, pp. 2066-2076. (doi: 10.1016/j.jacc.2024.02.052)
Collet, C. et al. (2024) Influence of pathophysiological patterns of coronary artery disease on immediate percutaneous coronary intervention outcomes. Circulation, (doi: 10.1161/circulationaha.124.069450)
Abraham, G. R., Berry, C., Fu, Q., Hoole, S. P., Weir-McCall, J. R. (2024) Differences in quantitative myocardial perfusion mapping by CMR at 1.5 T and 3 T. American Heart Journal Plus: Cardiology Research and Practice, 41, (doi: 10.1016/j.ahjo.2024.100388)
Olivera, S., Graham, D. (2024) Modelling pre-eclampsia and its cardiovascular effects. Nature Reviews Cardiology, 21, (doi: 10.1038/s41569-024-01006-0)
Kobayashi, M., Ferreira, J. P., Kevin, D., Bresso, E., Huttin, O., Bozec, E., Brunner La Rocca, H.-P., Delles, C., Clark, A. L., Edelmann, F., González, A., Heymans, S., Pellicori, P., Petutschnigg, J., Verdonschot, J. A.J., Rossignol, P., Cleland, J. G.F., Zannad, F., Girerd, N. (2024) Proteomic profiles of left atrial volume and its influence on response to spironolactone: findings from the HOMAGE trial and STANISLAS cohort. European Journal of Heart Failure, 26, pp. 1231-1241. (doi: 10.1002/ejhf.3202)
Cooke, S. F., Wright, T. A., Sin, Y. Y., Ling, J., Kyurkchieva, E., Phanthaphol, N., McSkimming, T., Herbert, K., Rebus, S., Biankin, A. V., Chang, D. K., Baillie, G. S., Blair, C. M. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14, (doi: 10.1038/s41598-024-59451-3)
Rankin, S., Elyan, B., Jones, R., Venugopal, B., Mark, P. B., Lees, J. S., Petrie, M. C., Lang, N. N. (2024) Cardiovascular eligibility criteria and adverse event reporting in combined immune checkpoint and VEGF inhibitors trials. JACC: CardioOncology, 6, pp. 267-279. (doi: 10.1016/j.jaccao.2023.12.010)
Glen, C., Morrow, A., Roditi, G., Hopkins, T., Macpherson, I., Stewart, P., Petrie, M. C., Berry, C., Epstein, F., Lang, N. N., Mangion, K. (2024) Cardiovascular sequalae of trastuzumab and anthracycline in long-term survivors of breast cancer. Heart, 110, pp. 650-656. (doi: 10.1136/heartjnl-2023-323437)
O’Callaghan, G., Fahy, M., O’Meara, S., Chawke, M., Waldron, E., Corry, M., Gallagher, S., Coyne, C., Lynch, J., Kennedy, E., Walsh, T., Cronin, H., Hannon, N., Fallon, C., Williams, D. J., Langhorne, P., Galvin, R., Horgan, F. (2024) Transitioning to home and beyond following stroke: a prospective cohort study of outcomes and needs. BMC Health Services Research, 24, pp. 449. (doi: 10.1186/s12913-024-10820-8)
Austin, R., Ellison, S., Kavuncu, D., Kinsey, L., Loftus, N. W., Masters, H., Richardson, J., Ting, F. F., Bernhardt, L. (2024) The BANCC research forum: supporting cardiac nurses to develop research and academic skills. British Journal of Cardiac Nursing, 19, (doi: 10.12968/bjca.2024.0022)
Hanson Ng, Y. Y., Dora, K. A., Lemmey, H. A. L., Lin, J., Alden, J., Wallis, L., Donovan, L., Shorthose, O., Leiper, F. C., Leiper, J., Garland, C. J. (2024) Asymmetric dimethylarginine enables depolarizing spikes and vasospasm in mesenteric and coronary resistance arteries. Hypertension, 81, pp. 764-775. (doi: 10.1161/HYPERTENSIONAHA.123.22454)
Yang, Y., Husmeier, D., Gao, H., Berry, C., Carrick, D., Radjenovic, A. (2024) Automatic detection of myocardial ischaemia using generalisable spatio-temporal hierarchical Bayesian modelling of DCE-MRI. Computerized Medical Imaging and Graphics, 113, (doi: 10.1016/j.compmedimag.2024.102333)
Neupane, D., Mukhtar, Q., Krajan Pardo, E. K., Acharya, S. D., Delles, C., Sharman, J. E., Cobb, L., Lackland, D. T., Moran, A., Weber, M. A., Olsen, M. H. (2024) Emerging Authors Program for building cardiovascular disease prevention and management research capacity in low- and middle-income countries: a collaboration of the U.S. Centers for Disease Control and Prevention, the Lancet Commission on Hypertension Group, Resolve to Save Lives, and the World Hypertension League. Journal of Human Hypertension, 38, pp. 380-381. (doi: 10.1038/s41371-023-00880-4)
Alsanosi, S. M., Padmanabhan, S. (2024) Potential applications of artificial intelligence (AI) in managing polypharmacy in Saudi Arabia: a narrative review. Healthcare, 12, (doi: 10.3390/healthcare12070788)
Sani, R. N., Connelly, P. J., Toft, M., Rowa-Dewar, N., Delles, C., Gasevic, D., Karaye, K. M. (2024) Rural-urban difference in the prevalence of hypertension in West Africa: a systematic review and meta-analysis. Journal of Human Hypertension, 38, pp. 352-364. (doi: 10.1038/s41371-022-00688-8)
Lim, M. W. S., Lucas-Herald, A. K., Mason, A., Delles, C., Connelly, P. J. (2024) Sex differences in the cardiovascular effects of GnRH analogues. Journal of Endocrinology, 261, (doi: 10.1530/JOE-23-0309)
Rossitto, G., Bertoldi, G., Rutkowski, J. M., Mitchell, B. M., Delles, C. (2024) Sodium, interstitium, lymphatics, and hypertension - A tale of hydraulics. Hypertension, 81, pp. 727-737. (doi: 10.1161/HYPERTENSIONAHA.123.17942)
Mavrogeorgis, E., Kondyli, M., Mischak, H., Vlahou, A., Siwy, J., Rossing, P., Campbell, A., Mels, C. M.C., Delles, C., Staessen, J. A., Latosinska, A., Persu, A. (2024) Multiple urinary peptides are associated with hypertension: a link to molecular pathophysiology. Journal of Hypertension, (doi: 10.1097/HJH.0000000000003726)
Wang, X. et al. (2024) Tobacco use and risk of acute stroke in 32 countries in the INTERSTROKE study: a case-control study. eClinicalMedicine, 70, (doi: 10.1016/j.eclinm.2024.102515)
Kite, T. A. et al. (2024) Complex percutaneous coronary intervention in patients unable to undergo coronary artery bypass grafting during the COVID-19 pandemic: insights from the UK-ReVasc Registry. Journal of Invasive Cardiology, (doi: 10.25270/jic/24.00030)
Haag, L., Richardson, J., Haig, C., Cunningham, Y., Fraser, H., Brosnahan, N., Ibbotson, T., Omerod, J., White, C., McIntosh, E., O'Donnell, K., Sattar, N., McConnachie, A., Lean, M., Blane, D., Combet, E. (2024) Baseline characteristics in the Remote Diet Intervention to REduce long-COVID Symptoms Trial (ReDIRECT) NIHR Open Research, 4, (doi: 10.3310/nihropenres.13522.1)
Setjiadi, D., Delles, C., Boutouyrie, P., Bruno, R. M. (2024) Inappropriate Pulse Wave Velocity to Blood Pressure Level: Definition and Clinical Determinants.
McCallum, L., Lip, S., Rostron, M., Hanna, R., Salimin, N. B. P. M., Nichol, S., Padmanabhan, S. (2024) OPTIMA-BP: empOwering PaTients in MAnaging Blood Pressure – protocol for a randomised parallel group study comparing use of Kvatchii web-based patient education portal as an addition to home blood pressure monitoring. Open Heart, 11, (doi: 10.1136/openhrt-2023-002535)
Sykes, R., Hanna, R., Berry, C. (2024) Prognostic importance of fractional flow reserve and left ventricular systolic dysfunction after percutaneous coronary intervention. JACC: Asia, 4, pp. 241-243. (doi: 10.1016/j.jacasi.2023.12.002)
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2023
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Richardson, J., Lee, M. (2023) Cardiovascular Screening Checks on Mongolian Nomads During the Khan Khentii Expedition, July 2023.
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2021
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Docherty, K. F., Campbell, R. T., Brooksbank, K. J.M., Godeseth, R. L., Forsyth, P., McConnachie, A., Roditi, G., Stanley, B., Welsh, P., Jhund, P. S., Petrie, M. C., McMurray, J. J.V. (2021) Rationale and methods of a randomized trial evaluating the effect of neprilysin inhibition on left ventricular remodelling. ESC Heart Failure, 8, pp. 129-138. (doi: 10.1002/ehf2.13137)
Maznyczka, A. M., McCartney, P. J., Oldroyd, K. G., Lindsay, M., McEntegart, M., Eteiba, H., Rocchiccioli, J. P., Good, R., Shaukat, A., Robertson, K., Malkin, C. J., Greenwood, J. P., Cotton, J. M., Hood, S., Watkins, S., Collison, D., Gillespie, L., Ford, T. J., Weir, R. A.P., McConnachie, A., Berry, C. (2021) Risk stratification guided by the index of microcirculatory resistance and left ventricular end-diastolic pressure in acute myocardial infarction. Circulation: Cardiovascular Interventions, 14, (doi: 10.1161/CIRCINTERVENTIONS.120.009529)
Baillie, G. S., Gulliver, C., Hoffmann, R. (2021) The enigmatic helicase DHX9 and its association with the hallmarks of cancer. Future Science OA, 7, (doi: 10.2144/fsoa-2020-0140)
Connelly, P. J., Clark, A., Touyz, R. M., Delles, C. (2021) Transgender adults, gender-affirming hormone therapy and blood pressure: a systematic review. Journal of Hypertension, 39, pp. 223-230. (doi: 10.1097/HJH.0000000000002632)
Corcoran, D., Radjenovic, A., Mordi, I., Nazir, S. A., Wilson, S. J., Hinder, M., Yates, D. P., Machineni, S., Alcantara, J., Prescott, M. F., Gugliotta, B., Pang, Y., Tzemos, N., Semple, S. I., Newby, D. E., McCann, G. P., Squire, I., Berry, C. (2021) Vascular effects of serelaxin in patients with stable coronary artery disease: a randomized placebo-controlled trial. Cardiovascular Research, 117, pp. 320-329. (doi: 10.1093/cvr/cvz345)
Moreton, F. C., Cullen, B., Dickie, D. A., Lopez Gonzalez, R., Santosh, C., Delles, C., Muir, K. W. (2021) Brain imaging factors associated with progression of subcortical hyperintensities in CADASIL over two year follow up. European Journal of Neurology, 28, pp. 220-228. (doi: 10.1111/ene.14534)
Dobbin, S. J.H., Petrie, M. C., Myles, R. C., Touyz, R. M., Lang, N. N. (2021) Cardiotoxic effects of angiogenesis inhibitors. Clinical Science, 135, pp. 71-100. (doi: 10.1042/CS20200305)
Fisher, R. J., Byrne, A., Chouliara, N., Lewis, S., Paley, L., Hoffman, A., Rudd, A., Robinson, T., Langhorne, P., Walker, M. (2021) Effect of stroke early supported discharge on length of hospital stay: analysis from a national stroke registry. BMJ Open, 11, (doi: 10.1136/bmjopen-2020-043480)
McCallum, L., Brooksbank, K., McConnachie, A., Aman, A., Lip, S., Dawson, J., MacIntyre, I. M., MacDonald, T. M., Webb, D. J., Padmanabhan, S. (2021) Rationale and design of the genotype-blinded trial of torasemide for the treatment of hypertension (BHF UMOD) American Journal of Hypertension, 34, pp. 92-99. (doi: 10.1093/ajh/hpaa166)
Willder, J. M., McCall, P., Messow, C.-M., Gillies, M., Berry, C., Shelley, B. (2021) Study protocol for COVID-RV: a multicentre prospective observational cohort study of right ventricular dysfunction in ventilated patients with COVID-19. BMJ Open, 11, (doi: 10.1136/bmjopen-2020-042098)
Jacobs, M., Benovoy, M., Chang, L.-C., Corcoran, D., Berry, C., Arai, A. E., Hsu, L.-Y. (2021) Automated segmental analysis of fully quantitative myocardial blood flow maps by first-pass perfusion cardiovascular magnetic resonance. IEEE Access, 9, pp. 52796-52811. (doi: 10.1109/ACCESS.2021.3070320)
Kamdar, A., Sykes, R., Morrow, A., Mangion, K., Berry, C. (2021) Cardiovascular outcomes of glucose lowering therapy in chronic kidney disease patients: a systematic review with meta-analysis. Reviews in Cardiovascular Medicine, 22, pp. 1479-1490. (doi: 10.31083/j.rcm2204152)
Small, H. Y., Delles, C. (2021) Letter to the Editor regarding Cunningham et al. 2020. Hypertension in Pregnancy, 40, pp. 133. (doi: 10.1080/10641955.2021.1899201)
McGettrick, M., MacLellan, A., McCaughey, P., Bagot, C., Brewis, M.J., Lang, N.N., Johnson, M.K., Church, A.C. (2021) Pulmonary thromboembolism in hospitalised patients with COVID-19: a retrospective national study of patients managed in critical care and ward environments in Scotland. BMJ Open, 11, (doi: 10.1136/bmjopen-2021-050281)
Sykes, R., Briscoe, M., Krystofiak, T., Peck, O., Mangion, K., Berry, C. (2021) Type 2 myocardial infarction and myocardial injury: eligibility for novel medical therapy to de-risk clinical trials. Open Heart, 8, (doi: 10.1136/openhrt-2021-001633)
Ang, D. T. Y., Berry, C. (2021) What an interventionalist needs to know about INOCA. Interventional Cardiology Review, 16, (doi: 10.15420/icr.2021.16)
Sykes, R., Doherty, D., Mangion, K., Morrow, A., Berry, C. (2021) What an interventionalist needs to know about MI with non-obstructive coronary arteries. Interventional Cardiology Review, 16, (doi: 10.15420/icr.2021.10)
2020
Rossitto, G., Mary, S., McAllister, C., Neves, K. B., Haddow, L., Rocchiccioli, J. P., Lang, N. N., Murphy, C. L., Touyz, R. M., Petrie, M. C., Delles, C. (2020) Reduced lymphatic reserve in heart failure with preserved ejection fraction. Journal of the American College of Cardiology, 76, pp. 2817-2829. (doi: 10.1016/j.jacc.2020.10.022)
Mangion, K. et al. (2020) The Chief Scientist Office cardiovascular and pulmonary imaging in SARS Coronavirus disease-19 (CISCO-19) study. Cardiovascular Research, 116, pp. 2185-2196. (doi: 10.1093/cvr/cvaa209)
Surendran, P. et al. (2020) Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nature Genetics, 52, pp. 1314-1332. (doi: 10.1038/s41588-020-00713-x)
Mangion, K., Loughrey, C., Auger, D. A., McComb, C., Lee, M. M., Corcoran, D., McEntegart, M., Davie, A., Good, R., Lindsay, M., Eteiba, H., Rocchiccioli, J. P., Watkins, S., Hood, S., Shaukat, A., Haig, C., Epstein, F. H., Berry, C. (2020) Displacement encoding with stimulated echoes enables the identification of infarct transmurality early postmyocardial infarction. Journal of Magnetic Resonance Imaging, 52, pp. 1722-1731. (doi: 10.1002/jmri.27295)
Zamai, N., Cortie, C. H., Jarvie, E. M., Onyiaodike, C. C., Alrehaili, A., Francois, M., Freeman, D. J., Meyer, B. J. (2020) In pregnancy, maternal HDL is specifically enriched in, and carries the highest proportion of, DHA in plasma. Prostaglandins, Leukotrienes and Essential Fatty Acids, 163, (doi: 10.1016/j.plefa.2020.102209)
Main, A., Fuller, W., Baillie, G. S. (2020) Post-translational regulation of cardiac myosin binding protein-C: a graphical review. Cellular Signalling, 76, (doi: 10.1016/j.cellsig.2020.109788)
O'Toole, D., Zaeri, A. A. I., Nicklin, S. A., French, A. T., Loughrey, C. M., Martin, T. P. (2020) Signalling pathways linking cysteine cathepsins to adverse cardiac remodelling. Cellular Signalling, 76, (doi: 10.1016/j.cellsig.2020.109770)
McFall, A., Nicklin, S. A., Work, L. M. (2020) The counter regulatory axis of the renin angiotensin system in the brain and ischaemic stroke: insight from preclinical stroke studies and therapeutic potential. Cellular Signalling, 76, (doi: 10.1016/j.cellsig.2020.109809)
Pashova, A., Work, L.M., Nicklin, S.A. (2020) The role of extracellular vesicles in neointima formation post vascular injury. Cellular Signalling, 76, (doi: 10.1016/j.cellsig.2020.109783)
Beazer, J. D., Patanapirunhakit, P., Gill, J. M.R., Graham, D., Karlsson, H., Ljunggren, S., Mulder, M., Freeman, D. J. (2020) High-density lipoprotein’s vascular protective functions in metabolic and cardiovascular disease - could extracellular vesicles be at play? Clinical Science, 134, pp. 2977-2986. (doi: 10.1042/CS20200892)
Ho, F. K., Celis-Morales, C. A., Gray, S. R., Katikireddi, S. V., Niedzwiedz, C. L., Hastie, C., Ferguson, L. D., Berry, C., Mackay, D. F., Gill, J. M.R., Pell, J. P., Sattar, N., Welsh, P. (2020) Modifiable and non-modifiable risk factors for COVID-19, and comparison to risk factors for influenza and pneumonia: results from a UK Biobank prospective cohort study. BMJ Open, 10, (doi: 10.1136/bmjopen-2020-040402)
Briscoe, M., Sykes, R. A., Krysztofiak, T., Peck, O. H., Mangion, K., Berry, C. (2020) Clinical Significance of Coronavirus Disease 2019 in Hospitalized Patients With Myocardial Injury. (doi: 10.1161/circ.142.suppl_3.15932)
Briscoe, M., Sykes, R. A., Krysztofiak, T., Mangion, K., Peck, O. H., Berry, C. (2020) Clinical Significance of Troponin Elevation in a Contemporary Hospitalized Population: Endotypes, Morbidity and In-hospital Mortality. (doi: 10.1161/circ.142.suppl_3.14870)
Charla, E., Mercer, J., Maffia, P., Nicklin, S. (2020) Extracellular vesicle signalling in atherosclerosis. Cellular Signalling, 75, (doi: 10.1016/j.cellsig.2020.109751)
McCartney, P. J. et al. (2020) Low-dose intracoronary alteplase during primary percutaneous coronary intervention in patients with acute myocardial infarction: the T-TIME three-arm RCT. Efficacy and Mechanism Evaluation, 7, (doi: 10.3310/eme07050)
Morrow, A. J. et al. (2020) Rationale and design of the Medical Research Council precision medicine with Zibotentan in microvascular angina (PRIZE) trial. American Heart Journal, 229, pp. 70-80. (doi: 10.1016/j.ahj.2020.07.007)
Langhorne, P., Audebert, H. J., Cadilhac, D. A., Kim, J., Lindsay, P. (2020) Stroke systems of care in high-income countries: what is optimal? Lancet, 396, pp. 1433-1442. (doi: 10.1016/S0140-6736(20)31363-5)
Kunadian, V., Chieffo, A., Camici, P. G., Berry, C., Escaned, J., Maas, A. H. E. M., Prescott, E., Karam, N., Appelman, Y., Fraccaro, C., Louise Buchanan, G., Manzo-Silberman, S., Al-Lamee, R., Regar, E., Lansky, A., Abbott, J. D., Badimon, L., Duncker, D. J., Mehran, R., Capodanno, D., Baumbach, A. (2020) An EAPCI expert consensus document on ischaemia with non-obstructive coronary arteries in collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation endorsed by Coronary Vasomotor Disorders International Study Group. European Heart Journal, 41, pp. 3504-3520. (doi: 10.1093/eurheartj/ehaa503)
Lang, N. N., Dobbin, S. J.H., Petrie, M. C. (2020) Vericiguat in worsening heart failure – agonising over, or celebrating, agonism. Cardiovascular Research, 116, pp. e152-e155. (doi: 10.1093/cvr/cvaa247)
Dowsett, L., Higgins, E., Alanazi, S., Alshuwayer, N. A., Leiper, F. C., Leiper, J. (2020) ADMA: A key player in the relationship between vascular dysfunction and inflammation in atherosclerosis. Journal of Clinical Medicine, 9, (doi: 10.3390/jcm9093026)
Ford, T. J., Corcoran, D., Padmanabhan, S., Aman, A., Rocchiccioli, P., Good, R., McEntegart, M., Maguire, J. J., Watkins, S., Eteiba, H., Shaukat, A., Lindsay, M., Robertson, K., Hood, S., McGeoch, R., McDade, R., Yii, E., Sattar, N., Hsu, L.-Y., Arai, A. E., Oldroyd, K. G., Touyz, R. M., Davenport, A. P., Berry, C. (2020) Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction. European Heart Journal, 41, pp. 3239-3252. (doi: 10.1093/eurheartj/ehz915)
Sattar, N., Ho, F. K., Gill, J. M.R., Ghouri, N., Gray, S. R., Celis-Morales, C. A., Katikireddi, S. V., Berry, C., Pell, J. P., McMurray, J. J.V., Welsh, P. (2020) BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: preliminary findings from UK biobank. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 14, pp. 1149-1151. (doi: 10.1016/j.dsx.2020.06.060)
Cameron, A. C., McMahon, K., Hall, M., Neves, K. B., Rios, F. J., Montezano, A. C., Welsh, P., Waterston, A., White, J., Mark, P. B., Touyz, R. M., Lang, N. N. (2020) Comprehensive characterisation of the vascular effects of cisplatin-based chemotherapy in patients with testicular cancer. JACC: CardioOncology, 2, pp. 443-455. (doi: 10.1016/j.jaccao.2020.06.004)
Ford, T. J., Ong, P., Sechtem, U., Beltrame, J., Camici, P. G., Crea, F., Kaski, J.-C., Bairey Merz, C. N., Pepine, C. J., Shimokawa, H., Berry, C. (2020) Assessment of vascular dysfunction in patients without obstructive coronary artery disease: why, how and when. JACC: Cardiovascular Interventions, 13, pp. 1847-1864. (doi: 10.1016/j.jcin.2020.05.052)
Rossitto, G., Mary, S., Chen, J. Y., Bodder, P., Chew, K. S., Neves, K. B., Alves, R. L., Montezano, A. C., Welsh, P., Petrie, M. C., Graham, D., Touyz, R. M., Delles, C. (2020) Tissue sodium excess is not hypertonic and reflects extracellular volume expansion. Nature Communications, 11, (doi: 10.1038/s41467-020-17820-2)
McClure, J. D., Ramsay, J. C., Berry, C. (2020) Pooled analysis of bleeding and major adverse cardiovascular events in clinical trials of time-constrained dual-antiplatelet therapy after percutaneous coronary intervention. Journal of the American Heart Association, 9, (doi: 10.1161/JAHA.120.017109)
Guzik, T. J., Mohiddin, S. A., Dimarco, A., Patel, V., Savvatis, K., Marelli-Berg, F. M., Madhur, M. S., Tomaszewksi, M., Maffia, P., D'Acquisto, F., Nicklin, S. A., Marian, A. J., Nosalski, R., Murray, E. C., Guzik, B., Berry, C., Touyz, R. M., Kreutz, R., Wang, D. W., Bhella, D., Sagliocco, O., Crea, F., Thomson, E. C., McInnes, I. B. (2020) COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options. Cardiovascular Research, 116, pp. 1666-1687. (doi: 10.1093/cvr/cvaa106)
Fisher, R. J., Byrne, A., Chouliara, N., Lewis, S., Paley, L., Hoffman, A., Rudd, A., Robinson, T., Langhorne, P., Walker, M. F. (2020) Effectiveness of stroke early supported discharge. Circulation: Cardiovascular Quality and Outcomes, 13, (doi: 10.1161/circoutcomes.119.006395)
Zou, Z.-G., Rios, F. J., Neves, K. B., Alves-Lopes, R., Ling, J., Baillie, G. S., Gao, X., Fuller, W., Camargo, L. L., Gudermann, T., Chubanov, V., Montezano, A. C., Touyz, R. M. (2020) Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function. Clinical Science, 134, pp. 2019-2035. (doi: 10.1042/CS20200827)
Connelly, P. J., Jandeleit-Dahm, K. A.M., Delles, C. (2020) Sex and gender aspects in vascular pathophysiology. Clinical Science, 134, pp. 2203-2207. (doi: 10.1042/CS20200876)
Campbell, R. T., Jasilek, A., Mischak, H., Nkuipou-Kenfack, E., Latosinska, A., Welsh, P. I., Jackson, C. E., Cannon, J., McConnachie, A., Delles, C., McMurray, J. J.V. (2020) The novel urinary proteomic classifier HF1 has similar diagnostic and prognostic utility to BNP in heart failure. ESC Heart Failure, 7, pp. 1595-1604. (doi: 10.1002/ehf2.12708)
Demin, A., Løge, B., Zhiteneva, O., Nishida, C., Whiting, S., Rippin, H., Delles, C., Karymbaeva, S., Wickramasinghe, K., Breda, J. (2020) Trans fatty acid elimination policy in member states of the Eurasian Economic Union: implementation challenges and capacity for enforcement. Journal of Clinical Hypertension, 22, pp. 1328-1337. (doi: 10.1111/jch.13945)
Tarar, O. M., Ahmed, K. M., Nishtar, N. A., Achakzai, A. B. K., Gulzar, Y., Delles, C., Al-Jawaldeh, A. (2020) Understanding the complexities of prevalence of trans fat and its control in food supply in Pakistan. Journal of Clinical Hypertension, 22, pp. 1338-1346. (doi: 10.1111/jch.13943)
Dobbie, L. J., Mackin, S. T., Hogarth, K., Lonergan, F., Kannenkeril, D., Brooksbank, K., Delles, C. (2020) Validation of semi-automated flow mediated dilation measurement in healthy volunteers. Blood Pressure Monitoring, 25, pp. 216-223. (doi: 10.1097/MBP.0000000000000448)
MacDonald, E. A., Madl, J., Greiner, J., Ramadan, A. F., Wells, S. M., Torrente, A. G., Kohl, P., Rog-Zielinska, E. A., Quinn, T. A. (2020) Sinoatrial node structure, mechanics, electrophysiology and the chronotropic response to stretch in rabbit and mouse. Frontiers in Physiology, 11, (doi: 10.3389/fphys.2020.00809)
Fong, L. C. W., Ford, T. J., da Costa, B. R., Jüni, P., Berry, C. (2020) Bias and loss to follow-up in cardiovascular randomized trials: a systematic review. Journal of the American Heart Association, 9, (doi: 10.1161/JAHA.119.015361)
Bulluck, H., Carberry, J., Carrick, D., McEntegart, M., Petrie, M. C., Eteiba, H., Hood, S., Watkins, S., Lindsay, M., Mahrous, A., Ford, I., Oldroyd, K. G., Berry, C. (2020) Redefining adverse and reverse left ventricular remodeling by cardiovascular magnetic resonance following ST-segment elevation myocardial infarction and their implications on long-term prognosis. Circulation: Cardiovascular Imaging, 13, (doi: 10.1161/CIRCIMAGING.119.009937)
Louca, P., Mompeo, O., Leeming, E. R., Berry, S. E., Mangino, M., Spector, T. D., Padmanabhan, S., Menni, C. (2020) Dietary influence on systolic and diastolic blood pressure in the TwinsUK cohort. Nutrients, 12, (doi: 10.3390/nu12072130)
Drozdowska, B. A., Elliott, E., Taylor-Rowan, M., Shaw, R. C., Cuthbertson, G., Langhorne, P., Quinn, T. J. (2020) Cardiovascular risk factors indirectly affect acute post-stroke cognition through stroke severity and prior cognitive impairment: A moderated mediation analysis. Alzheimer's Research and Therapy, 12, (doi: 10.1186/s13195-020-00653-y)
Lees, J. S., Mangion, K., Rutherford, E., Witham, M. D., Woodward, R., Roditi, G., Hopkins, T., Brooksbank, K., Jardine, A., Mark, P. B. (2020) Vitamin K for kidney transplant organ recipients: investigating vEssel stiffness (ViKTORIES): study rationale and protocol of a randomised controlled trial. Open Heart, 7, (doi: 10.1136/openhrt-2019-001070)
Dobbin, S. J.H., Mangion, K., Berry, C., Roditi, G., Basak, S., Sourbron, S., White, J., Venugopal, B., Touyz, R. M., Jones, R. J., Petrie, M. C., Lang, N. N. (2020) Cardiotoxicity and myocardial hypoperfusion associated with anti-VEGF therapies: prospective cardiac magnetic resonance imaging in patients with cancer. European Journal of Heart Failure, 22, pp. 1276-1277. (doi: 10.1002/ejhf.1847)
Currie, G., Mary, S., Delles, C. (2020) Is there a role for proteomics in diabetic renal disease? NDT Plus, 35, pp. 1133-1135. (doi: 10.1093/ndt/gfz017)
Riddell, A., McBride, M., Braun, T., Nicklin, S. A., Cameron, E., Loughrey, C. M., Martin, T. P. (2020) RUNX1: an emerging therapeutic target for cardiovascular disease. Cardiovascular Research, 116, pp. 1410-1423. (doi: 10.1093/cvr/cvaa034)
Williams, J. J.L., Baillie, G. S., Palmer, T. M. (2020) Investigation of Novel Cavin-1/Suppressor of Cytokine Signaling 3 (SOCS3) Interactions by Coimmunoprecipitation, Peptide Pull-Down, and Peptide Array Overlay Approaches. Springer
Al-Hussaini, A., Abdelaty, A. M.S.E.K., Gulsin, G. S., Arnold, J. R., Garcia-Guimaraes, M., Premawardhana, D., Budgeon, C., Wood, A., Natarajan, N., Mangion, K., Rakhit, R., Hoole, S. P., Johnson, T. W., Berry, C., Hudson, I., Gershlick, A. H., Ladwiniec, A., Kovac, J., Squire, I., Samani, N. J., Plein, S., McCann, G. P., Adlam, D. (2020) Chronic infarct size after spontaneous coronary artery dissection: implications for pathophysiology and clinical management. European Heart Journal, 41, pp. 2197-2205. (doi: 10.1093/eurheartj/ehz895)
Gök, C., Plain, F., Robertson, A., Howie, J., Baillie, G. S., Fraser, N. J., Fuller, W. (2020) Dynamic palmitoylation of the sodium-calcium exchanger modulates its structure, affinity for lipid ordered domains, and inhibition by XIP. Cell Reports, 31, (doi: 10.1016/j.celrep.2020.107697)
Derakhshan, A. et al. (2020) Association of maternal thyroid function with birth weight: a systematic review and individual-participant data meta-analysis. Lancet Diabetes and Endocrinology, 8, pp. 501-510. (doi: 10.1016/S2213-8587(20)30061-9)
Sidik, N., McDermott, M., McEntegart, M. B., Berry, C. (2020) Chest pain without obstructive coronary artery disease: a case series report. European Heart Journal: Case Reports, 4, pp. 1-6. (doi: 10.1093/ehjcr/ytaa060)
Walters, R., Collier, J. M., Braighi Carvalho, L., Langhorne, P., Katijjahbe, M. A., Tan, D., Moodie, M., Bernhardt, J. (2020) Exploring post acute rehabilitation service use and outcomes for working age stroke survivors (≤65 years) in Australia, UK and South East Asia: data from the international AVERT trial. BMJ Open, 10, (doi: 10.1136/bmjopen-2019-035850)
Picone, D. S., Deshpande, R. A., Schultz, M. G., Fonseca, R., Campbell, N. R.C., Delles, C., Hecht-Olsen, M., Schutte, A. E., Stergiou, G., Padwal, R., Zhang, X.-H., Sharman, J. E. (2020) Nonvalidated home blood pressure devices dominate the online marketplace in Australia: major implications for cardiovascular risk management. Hypertension, 75, pp. 1593-1599. (doi: 10.1161/hypertensionaha.120.14719)
Ntalla, I. et al. (2020) Multi-ancestry GWAS of the electrocardiographic PR interval identifies 202 loci underlying cardiac conduction. Nature Communications, 11, (doi: 10.1038/s41467-020-15706-x)
Lip, S., Padmanabhan, S. (2020) Genomics of blood pressure and hypertension: extending the mosaic theory toward stratification. Canadian Journal of Cardiology, 36, pp. 694-705. (doi: 10.1016/j.cjca.2020.03.001)
Delles, C., Olfert, M. (2020) Electronic cigarettes: how bad are they for your health? Cardiovascular Research, 116, pp. e64-e66. (doi: 10.1093/cvr/cvaa041)
Collison, D., McClure, J. D., Berry, C., Oldroyd, K. G. (2020) A randomized controlled trial of a physiology‐guided percutaneous coronary intervention optimization strategy: rationale and design of the TARGET FFR study. Clinical Cardiology, 43, pp. 414-422. (doi: 10.1002/clc.23342)
Maznyczka, A. M., Oldroyd, K. G., Greenwood, J. P., McCartney, P. J., Cotton, J., Lindsay, M., McEntegart, M., Rocchiccioli, J. P., Good, R., Robertson, K., Eteiba, H., Watkins, S., Shaukat, A., Petrie, C. J., Murphy, A., Petrie, M. C., Berry, C. (2020) Comparative significance of invasive measures of microvascular injury in acute myocardial infarction. Circulation: Cardiovascular Interventions, 13, (doi: 10.1161/CIRCINTERVENTIONS.119.008505)
Tzolos, E., Adamson, P.D., Hall, P.S., MacPherson, I.R., Oikonomidou, O., MacLean, M., Lewis, S.C., McVicars, H., Newby, D.E., Mills, N.L., Lang, N.N., Henriksen, P.A. (2020) Dynamic changes in high-sensitivity cardiac troponin I in response to anthracycline-based chemotherapy. Clinical Oncology, 32, pp. 292-297. (doi: 10.1016/j.clon.2019.11.008)
Hennigan, B., Berry, C., Collison, D., Corcoran, D., Eteiba, H., Good, R., McEntegart, M., Watkins, S., McClure, J., Mangion, K., Ford, T., Petrie, M. C., Hood, S., Rocchiccioli, P., Shaukat, A., Lindsay, M., Oldroyd, K. G. (2020) Percutaneous coronary intervention versus medical therapy in patients with angina and grey-zone fractional flow reserve values: a randomised clinical trial. Heart, 106, pp. 714-715. (doi: 10.1136/heartjnl-2019-316075)
Li, W., Lazarus, A., Gao, H., Martinez De Azcona Naharro, A., Fontana, M., Hawkins, P., Biswas, S., Janiczek, R., Cox, J., Berry, C., Husmeier, D., Luo, X. (2020) Analysis of cardiac amyloidosis progression using model-based markers. Frontiers in Physiology, 11, (doi: 10.3389/fphys.2020.00324)
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2017
Avtaar Singh, S. S., Das De, S., Spadaccio, C., Berry, C., Al-Attar, N. (2017) An overview of different methods of myocardial protection currently employed peri-transplantation. Vessel Plus, 1, pp. 213-229. (doi: 10.20517/2574-1209.2017.26)
Van't Veer, M., Pijls, N. H.J., Hennigan, B., Watkins, S., Ali, Z. A., De Bruyne, B., Zimmermann, F. M., van Nunen, L. X., Barbato, E., Berry, C., Oldroyd, K. G. (2017) Comparison of different diastolic resting indexes to iFR: are they all equal? Journal of the American College of Cardiology, 70, pp. 3088-3096. (doi: 10.1016/j.jacc.2017.10.066)
Ford, T. J., Berry, C., De Bruyne, B., Yong, A. C.S., Barlis, P., Fearon, W. F., Ng, M. K.C. (2017) Physiological predictors of acute coronary syndromes: emerging insights from the plaque to the vulnerable patient. JACC: Cardiovascular Interventions, 10, pp. 2539-2547. (doi: 10.1016/j.jcin.2017.08.059)
Berry, C., McClure, J. D., Oldroyd, K. G. (2017) Meta-analysis of death and myocardial infarction in the DEFINE-FLAIR and iFR-SWEDEHEART trials: a hypothesis generating note of caution. Circulation, 136, pp. 2389-2391. (doi: 10.1161/CIRCULATIONAHA.117.030430)
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O'Neill, D.G., Riddell, A., Church, D.B., Owen, L., Brodbelt, D.C., Hall, J.L. (2017) Urinary incontinence in bitches under primary veterinary care in England: prevalence and risk factors. Journal of Small Animal Practice, 58, pp. 685-693. (doi: 10.1111/jsap.12731)
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MacDonald, E. A., Stoyek, M. R., Rose, R. A., Quinn, T. A. (2017) Intrinsic regulation of sinoatrial node function and the zebrafish as a model of stretch effects on pacemaking. Progress in Biophysics and Molecular Biology, 130, pp. 198-211. (doi: 10.1016/j.pbiomolbio.2017.07.012)
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Lemonidis, K., MacLeod, R., Baillie, G. S., Chamberlain, L. H. (2017) Peptide array based screening reveals a large number of proteins interacting with the ankyrin repeat domain of the zDHHC17 S-acyltransferase. Journal of Biological Chemistry, 292, pp. 17190-17202. (doi: 10.1074/jbc.M117.799650)
Gao, H., Mangion, K., Carrick, D., Husmeier, D., Luo, X., Berry, C. (2017) Estimating prognosis in patients with acute myocardial infarction using personalized computational heart models. Scientific Reports, 7, (doi: 10.1038/s41598-017-13635-2)
Kohli-Lynch, C.N., Boyd, K., Briggs, A., Delles, C. (2017) A Framework for the Cost-Effectiveness Analysis of Novel Biomarker Testing in Cardiovascular Disease. (doi: 10.1016/j.jval.2017.08.040)
Stevens, K., Denby, L., Patel, R. K., Mark, P. B., Kettlewell, S., Smith, G. L., Clancy, M. J., Delles, C., Jardine, A. G. (2017) Deleterious effects of phosphate on vascular and endothelial function via disruption to the nitric oxide pathway. Nephrology Dialysis Transplantation, 32, pp. 1617-1627. (doi: 10.1093/ndt/gfw252)
Clarke, T.-K., Adams, M.J., Davies, G., Howard, D.M., Hall, L.S., Padmanabhan, S., Murray, A.D., Smith, B.H., Campbell, A., Hayward, C., Porteous, D.J., Deary, I.J., McIntosh, A.M. (2017) Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117) Molecular Psychiatry, 22, pp. 1376-1384. (doi: 10.1038/mp.2017.153)
Nishi, T., Johnson, N. P., De Bruyne, B., Berry, C., Gould, K. L., Jeremias, A., Oldroyd, K. G., Kobayashi, Y., Choi, D.-H., Pijls, N. H.J., Fearon, W. F. (2017) Influence of contrast media dose and osmolality on the diagnostic performance of contrast fractional flow reserve. Circulation: Cardiovascular Interventions, 10, (doi: 10.1161/CIRCINTERVENTIONS.117.004985)
Gao, H., Qi, N., Feng, L., Ma, X., Danton, M., Berry, C., Luo, X. (2017) Modelling mitral valvular dynamics–current trend and future directions. International Journal for Numerical Methods in Biomedical Engineering, 33, (doi: 10.1002/cnm.2858)
Queen, A. B., Lowrie, R., Richardson, J., Williamson, A. E. (2017) Multimorbidity, disadvantage and patient engagement within a specialist homeless health service in the UK. BJGP Open, 1, (doi: 10.3399/bjgpopen17X100941)
Kraja, A. T. et al. (2017) New blood pressure–associated loci identified in meta-analyses of 475 000 individuals. Circulation: Cardiovascular Genetics, 10, (doi: 10.1161/CIRCGENETICS.117.001778)
Padmanabhan, S., Joe, B. (2017) Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans. Physiological Reviews, 97, pp. 1469-1528. (doi: 10.1152/physrev.00035.2016)
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Gao, H., Feng, L., Qi, N., Berry, C., Griffith, B. E., Luo, X. (2017) A coupled mitral valve - left ventricle model with fluid-structure interaction. Medical Engineering and Physics, 47, pp. 128-136. (doi: 10.1016/j.medengphy.2017.06.042)
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Bagot, C.N., Leishman, E., Onyiaodike, C.C., Jordan, F., Freeman, D.J. (2017) Normal pregnancy is associated with an increase in thrombin generation from the very early stages of the first trimester. Thrombosis Research, 157, pp. 49-54. (doi: 10.1016/j.thromres.2017.06.027)
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Gao, X., Salomon, C., Freeman, D. J. (2017) Extracellular vesicles from adipose tissue - a potential role in obesity and type 2 diabetes? Frontiers in Endocrinology, 8, (doi: 10.3389/fendo.2017.00202)
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Forsyth, P., Fleming, L., Moir, L., Mcclusky, L., Watson, N., Meiklejohn, J., Lowrie, R. (2015) Improving Medication Adherence in Patients with Chronic Heart Failure: A Feasibility Study.
Mangion, K., Carrick, D., Payne, A., McClure, J., Mason, M., Petrie, M., McEntegart, M., Eteiba, H., Oldroyd, K., Berry, C. (2015) Infarct burden following multivessel PCI vs. infarct-only PCI in patients with acute STEMI: the Glasgow PRAMI CMR sub-study. Journal of Cardiovascular Magnetic Resonance, 17, (doi: 10.1186/1532-429X-17-S1-O9)
Souteyrand, G., Amabile, N., Combaret, N., Hammas, S., Prati, F., Berry, C., Pereira, B., Lusson, J.-R., Caussin, C., Motreff, P. (2015) Invasive management without stents in selected acute coronary syndrome patients with a large thrombus burden: a prospective study of optical coherence tomography guided treatment decisions. EuroIntervention, 11, pp. 895-904. (doi: 10.4244/eijy14m07_18)
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PGR
- Post Graduate Research Student
- Research title: the role of IL-15 in vascular and cardiac fibrosis and remodelling
Despite substantial progress in our knowledge and management of blood pressure, hypertension remains one of the most important modifiable cardiovascular risk factors. The importance of hypertension is such that in a national report the condition was named ‘Scotland’s Silent Killer’.
The University of Glasgow has a proud tradition of hypertension research, and this continues in the School of Cardiovascular and Metabolic Health. Our bench, to bedside, to population approach has resulted in a new understanding of the pathophysiology of hypertension and the identification of potential new targets for intervention. In our labs, we use techniques spanning from molecular biology and cellular assays to transgenic mouse models, myography, and blood pressure telemetry. While others in the team translate these findings to clinical trials and public health work.
An exemplar of our approach can be seen in our aldosterone focused research. The hormone aldosterone is a key regulator of the cardiovascular system but its role as an important and treatable driver of hypertension has been poorly appreciated. By improving our understanding of how aldosterone production is regulated within the healthy human body and how this regulation can break down, we aim to improve diagnosis and treatment.
Our work goes beyond the laboratories and team members have had pivotal roles in creating clinical guidelines and raising standards in blood pressure assessment and treatment. There is still an enormous amount of work to do, as at presnet one-third of adults in Scotland have high blood pressure and only around one-quarter of these people are on adequate treatment. In addition to our science, we are actively involved in public engagement events with a focus on blood pressure management and lifestyle-based reductions.
Current areas:
- Role of sodium and uromodulin in the pathogenesis of hypertension.
- Asymmetric dimethylarginine (ADMA) is a risk factor and therapeutic target through its action on the nitric oxide synthase family of enzymes.
- The use "omics" (proteomics, metabolomics, transcriptomics and epigenomics) AI (machine learning), systems biology and bioinformatics in the diagnosis of hypertension.
- Laboratory-based analysis focused on a better understanding of the regulatory pathways that control aldosterone secretion by the adrenal cortex and its action on vascular cells.
- Clinical trials that seek to explore how common genetic differences in the human population affect aldosterone production and predispose certain individuals to increased risk of hypertension.
- Bioinformatic analysis of our data, using cutting-edge AI and pathway-based approaches to identify novel pathways and biomarkers for future research.
- Hypertension and lifetime cardiovascular risk.