Hypertension

We study all aspects of hypertension (high blood pressure) from understanding the pathophysiology to describing the epidemiology and developing new potential treatments. 

Staff

Publications

2024

Docherty, N. G., Delles, C., López-Hernández, F. J. (2024) Reframing acute kidney injury as a pathophysiological continuum of disrupted renal excretory function. Acta Physiologica,

Sin, Y. Y., Cameron, R. T., Schepers, M., MacLeod, R., Wright, T. A., Paes, D., van den Hove, D., Willems, E., Vanmierlo, T., Prickaerts, J., Blair, C. M., Baillie, G. S. (2024) Beta-amyloid interacts with and activates the longform phosphodiesterase PDE4D5 in neuronal cells to reduce cAMP availability. FEBS Letters, (doi: 10.1002/1873-3468.14902)

Curtain, J. P., Talebi, A., McIntosh, A., McConnachie, A., O’Donnell, J., Welsh, P., Osmanska, J., Lee, M. M.Y., Sonecki, P., Akl, T., Seo, J., Gopinathan, V., Hurwitz, J., Thiagarajan, S., Pettit, S., Kalra, P. R., Patel, R. K., Mark, P. B., Lang, N. N., McMurray, J. J.V., Petrie, M. C., Gardner, R. S., Jhund, P. (2024) Measuring congestion with a non-invasive monitoring device in heart failure and haemodialysis: CONGEST-HF. European Journal of Heart Failure,

Cooke, S. F., Wright, T. A., Sin, Y. Y., Ling, J., Kyurkchieva, E., Phanthaphol, N., McSkimming, T., Herbert, K., Rebus, S., Biankin, A. V., Chang, D. K., Baillie, G. S., Blair, C. M. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14, (doi: 10.1038/s41598-024-59451-3)

Lang, N., Rankin, S., Elyan, B., Jones, R., Venugopal, B., Mark, P. B., Lees, J., Petrie, M., Lang, N. (2024) Cardiovascular eligibility criteria and adverse event reporting in combined immune checkpoint and VEGF inhibitors trials. JACC: CardioOncology, 6, pp. 267-279. (doi: 10.1016/j.jaccao.2023.12.010)

Glen, C., Morrow, A., Roditi, G., Hopkins, T., Macpherson, I., Stewart, P., Petrie, M. C., Berry, C., Epstein, F., Lang, N. N., Mangion, K. (2024) Cardiovascular sequalae of trastuzumab and anthracycline in long-term survivors of breast cancer. Heart, 110, pp. 650-656. (doi: 10.1136/heartjnl-2023-323437)

Carberry, J., Petrie, M. C., Lee, M. M.Y., Brooksbank, K., Campbell, R. T., Good, R., Jhund, P. S., Kellman, P., Lang, N. N., Mangion, K., Mark, P. B., McConnachie, A., McMurray, J. J.V., Meyer, B., Orchard, V., Shaukat, A., Watkins, S., Welsh, P., Sattar, N., Berry, C., Docherty, K. F. (2024) Empagliflozin to prevent progressive adverse remodelling after myocardial infarction (EMPRESS-MI): rationale and design. ESC Heart Failure,

O’Callaghan, G., Fahy, M., O’Meara, S., Chawke, M., Waldron, E., Corry, M., Gallagher, S., Coyne, C., Lynch, J., Kennedy, E., Walsh, T., Cronin, H., Hannon, N., Fallon, C., Williams, D. J., Langhorne, P., Galvin, R., Horgan, F. (2024) Transitioning to home and beyond following stroke: a prospective cohort study of outcomes and needs. BMC Health Services Research, 24, pp. 449. (doi: 10.1186/s12913-024-10820-8)

Collet, C. et al. (2024) A systematic approach to the evaluation of the coronary microcirculation using bolus thermodilution: CATH CMD. Journal of the Society for Cardiovascular Angiography and Interventions, (doi: 10.1016/j.jscai.2024.101934)

Hanson Ng, Y. Y., Dora, K. A., Lemmey, H. A. L., Lin, J., Alden, J., Wallis, L., Donovan, L., Shorthose, O., Leiper, F. C., Leiper, J., Garland, C. J. (2024) Asymmetric dimethylarginine enables depolarizing spikes and vasospasm in mesenteric and coronary resistance arteries. Hypertension, 81, pp. 764-775. (doi: 10.1161/HYPERTENSIONAHA.123.22454)

Yang, Y., Husmeier, D., Gao, H., Berry, C., Carrick, D., Radjenovic, A. (2024) Automatic detection of myocardial ischaemia using generalisable spatio-temporal hierarchical Bayesian modelling of DCE-MRI. Computerized Medical Imaging and Graphics, 113, (doi: 10.1016/j.compmedimag.2024.102333)

Alsanosi, S. M., Padmanabhan, S. (2024) Potential applications of artificial intelligence (AI) in managing polypharmacy in Saudi Arabia: a narrative review. Healthcare, 12, (doi: 10.3390/healthcare12070788)

Lim, M. W. S., Lucas-Herald, A. K., Mason, A., Delles, C., Connelly, P. J. (2024) Sex differences in the cardiovascular effects of GnRH analogues. Journal of Endocrinology, 261, (doi: 10.1530/JOE-23-0309)

Docherty, K. F., McMurray, J. J.V., Kalra, P., Cleland, J. G.F., Lang, N. N., Petrie, M. C., Robertson, M., Ford, I. (2024) Intravenous iron and SGLT2 inhibitors in iron-deficient patients with heart failure and reduced ejection fraction. ESC Heart Failure, (doi: 10.1002/ehf2.14742)

Tran, T. Q. B., Lip, S., du Toit, C., Kalaria, T. K., Bhaskar, R. K., O'Neil, A. Q., Graff, B., Hoffmann, M., Szyndler, A., Polonis, K., Wolf, J., Reddy, S., Narkiewicz, K., Dasgupta, I., Dominiczak, A. F., Visweswaran, S., McCallum, L., Padmanabhan, S. (2024) Assessing machine learning for diagnostic classification of hypertension types identified by ambulatory blood pressure monitoring. CJC Open, (doi: 10.1016/j.cjco.2024.03.005)

Kobayashi, M., Ferreira, J. P., Kevin, D., Bresso, E., Huttin, O., Bozec, E., Brunner La Rocca, H.-P., Delles, C., Clark, A. L., Edelmann, F., González, A., Heymans, S., Pellicori, P., Petutschnigg, J., Verdonschot, J. A.J., Rossignol, P., Cleland, J. G.F., Zannad, F., Girerd, N. (2024) Proteomic profiles of left atrial volume and its influence on response to spironolactone: findings from the HOMAGE trial and STANISLAS cohort. European Journal of Heart Failure,

Ang, D. T.Y., Carrick, D., Kamdar, A., Sykes, R., McGeoch, R. J., Collison, D., McConnachie, A., Berry, C. (2024) Intracoronary adenosine derived coronary flow reserve and index of microvascular resistance. Circulation: Cardiovascular Interventions,

McCallum, L., Lip, S., Rostron, M., Hanna, R., Salimin, N. B. P. M., Nichol, S., Padmanabhan, S. (2024) OPTIMA-BP: empOwering PaTients in MAnaging Blood Pressure – protocol for a randomised parallel group study comparing use of Kvatchii web-based patient education portal as an addition to home blood pressure monitoring. Open Heart, 11, (doi: 10.1136/openhrt-2023-002535)

Bosserdt, M. et al. (2024) Age and computed tomography and invasive coronary angiography in stable chest pain: a prespecified secondary analysis of the discharge randomized clinical trial. JAMA Cardiology, 9, pp. 346-356. (doi: 10.1001/jamacardio.2024.0001)

Morrow, A. J. et al. (2024) Socioeconomic deprivation and illness trajectory in the Scottish population after COVID-19 hospitalization. Communications Medicine, 4, (doi: 10.1038/s43856-024-00455-5)

Kelham, M., Vyas, R., Rameseshan, R., Rathod, K., de Winter, R.J., de Winter, R.W., Bendz, B., Thiele, H., Hirlekar, G., Morici, N., Myat, A., Michalis, L., Sanchis, J., Kunadian, V., Berry, C., Mathur, A., Jones, D. (2024) 100.03 Routine Invasive Versus Conservative Management of Non-ST Elevation Acute Coronary Syndromes in Patients With Previous Coronary Artery Bypass Grafting: A Systematic Review and Meta-Analysis of Randomised Clinical Trials. (doi: 10.1016/j.jcin.2024.01.082)

Rossitto, G., Bertoldi, G., Rutkowski, J. M., Mitchell, B. M., Delles, C. (2024) Sodium, interstitium, lymphatics, and hypertension - A tale of hydraulics: Salt series. Hypertension, (doi: 10.1161/HYPERTENSIONAHA.123.17942)

Loughrey, C. et al. (2024) A novel ryanodine receptor 2 inhibitor, M201-A, enhances natriuresis, renal function and lusi-inotropic action: Pre-clinical and phase I study. British Journal of Pharmacology,

Sykes, R., Hanna, R., Berry, C. (2024) Prognostic importance of fractional flow reserve and left ventricular systolic dysfunction after percutaneous coronary intervention. JACC: Asia, (doi: 10.1016/j.jacasi.2023.12.002)

Olowoyo, P. et al. (2024) Priorities to reduce the burden of hypertension in Africa through ACHIEVE. Lancet Global Health, 12, pp. e192-e193. (doi: 10.1016/S2214-109X(23)00540-5)

Murphy, R. et al. (2024) Variations in the prevalence of atrial fibrillation, and in the strength of its association with ischemic stroke, in countries with different income levels: INTERSTROKE case–control study. International Journal of Stroke, (doi: 10.1177/17474930241227783)

Mary, S., Conti-Ramsden, F., Boder, P., Parveen, H., Setjiadi, D., Fleminger, J., Brockbank, A., Graham, D., Bramham, K., Chappell, L. C., Delles, C. (2024) Pregnancy-associated changes in urinary uromodulin excretion in chronic hypertension. Journal of Nephrology, (doi: 10.1007/s40620-023-01830-6)

Kharlamov, A., Sherriff, N., Delles, C., van der Harst, P. (2024) Tackling cardiovascular healthcare disparities for LGBTQIA+ population: a call to action in the European Society of Cardiology. European Heart Journal, (doi: 10.1093/eurheartj/ehad882)

Sidik, N. P., Stanley, B., Sykes, R., Morrow, A. J., Bradley, C. P., Mcdermott, M., Ford, T., Roditi, G., Hargreaves, A., Stobo, D., Adams, J., Byrne, J., Mahrous, A., Young, R., Carrick, D., McGeoch, R., Corcoran, D., Lang, N. N., Heggie, R., Wu, O., McEntegart, M. B., McConnachie, A., Berry, C. (2024) Invasive endotyping in patients with angina and no obstructive coronary artery disease: a randomized controlled trial. Circulation, 149, pp. 7-23. (doi: 10.1161/CIRCULATIONAHA.123.064751)

Osmanska, J., Brooksbank, K., Docherty, K. F., Robertson, S., Wetherall, K., McConnachie, A., Hu, J., Gardner, R. S., Clark, A. L., Squire, I. B., Kalra, P. R., Jhund, P. S., Muntendam, P., McMurray, J. J.V., Petrie, M. C., Campbell, R. T. (2024) A novel, small-volume subcutaneous furosemide formulation delivered by an abdominal patch infusor device in patients with heart failure: results of two phase I studies. European Heart Journal: Cardiovascular Pharmacotherapy, 10, pp. 35-44. (doi: 10.1093/ehjcvp/pvad073)

McFall, A., Graham, D., Nicklin, S. A., Work, L. M. (2024) Unscheduled changes in pre-clinical stroke model housing contributes to variance in physiological and behavioural data outcomes: a post hoc analysis. Brain and Neuroscience Advances, 8, (doi: 10.1177/23982128241238934)

2023

Gulliver, C., Busiau, T., Byrne, A., Findlay, J. E., Hoffmann, R., Baillie, G. (2023) cAMP-phosphodiesterase 4D7 (PDE4D7) forms a cAMP signalosome complex with DHX9 and is implicated in prostate cancer progression. Molecular Oncology, (doi: 10.1002/1878-0261.13572)

Glen, C., Adam, S., Coats, C. J., Lang, N. N. (2023) Reply: Cardiotoxicity of BRAF/MEK inhibitors according to HFA/ICOS cardiotoxicity risk category. JACC: CardioOncology, 5, pp. 850. (doi: 10.1016/j.jaccao.2023.10.003)

Freeman-Jones, E., Miller, W. H., Work, L. M., Fullerton, J. L. (2023) Polypathologies and animal models of traumatic brain injury. Brain Sciences, 13, (doi: 10.3390/brainsci13121709)

Bagordo, D., Rossi, G. P., Delles, C., Wiig, H., Rossitto, G. (2023) The tangram of sodium and fluid balance: salt series. Hypertension, (doi: 10.1161/HYPERTENSIONAHA.123.19569)

Neupane, D., Mukhtar, Q., Krajan Pardo, E. K., Acharya, S. D., Delles, C., Sharman, J. E., Cobb, L., Lackland, D. T., Moran, A., Weber, M. A., Olsen, M. H. (2023) Emerging Authors Program for building cardiovascular disease prevention and management research capacity in low- and middle-income countries: a collaboration of the U.S. Centers for Disease Control and Prevention, the Lancet Commission on Hypertension Group, Resolve to Save Lives, and the World Hypertension League. Journal of Human Hypertension, pp. -023. (doi: 10.1038/s41371-023-00880-4)

Welsh, S. A., Hussey, K., Brittenden, J., Orr, D. J., Quinn, T. (2023) Frailty Assessment in Vascular OUtpatients Review (FAVOUR) PROTOCOL – single-centre prospective cohort study comparing feasibility and prognostic value of commonly used frailty assessment tools. BMJ Open, 13, (doi: 10.1136/bmjopen-2023-079387)

Lyon, M., Fullerton, J. L., Kennedy, S., Work, L. M. (2023) Hypertension & dementia: pathophysiology & potential utility of antihypertensives in reducing disease burden. Pharmacology and Therapeutics, (doi: 10.1016/j.pharmthera.2023.108575)

Connelly, P., Osmanska, J., Lee, M. M.Y., Delles, C., McEntegart, M. B., Byrne, J. (2023) A case report of myocardial infarction in a young transgender man with testosterone therapy? raising awareness on healthcare issues in the transgender community and a call for further research. European Heart Journal: Case Reports, 7, (doi: 10.1093/ehjcr/ytad562)

McErlane, J., McCall, P., Willder, J., Berry, C., Shelley, B. (2023) Cardiac biomarkers and right ventricular dysfunction are independently associated with one year mortality in patients with COVID-19 receiving mechanical ventilation: a prospective cohort study. CHEST Critical Care, 1, (doi: 10.1016/j.chstcc.2023.100015)

Berry, C. et al. (2023) Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study. Heart and Mind, 7, pp. 235-245. (doi: 10.4103/hm.HM-D-23-00037)

Henriksen, P. A. et al. (2023) Multicenter, prospective, randomized controlled trial of high-sensitivity cardiac troponin I–guided combination angiotensin receptor blockade and beta-blocker therapy to prevent anthracycline cardiotoxicity: The Cardiac CARE trial. Circulation, 148, pp. 1680-1690. (doi: 10.1161/CIRCULATIONAHA.123.064274)

Desson, Z., Sharman, J. E., Searles, A., Schutte, A. E., Delles, C., Olsen, M. H., Ordunez, P., Hure, A., Morton, R., Figtree, G., Webster, J., Jennings, G., Redfern, J., Nicolls, S., McNamara, M., Deeming, S., Doyle, K., Ramanathan, S. (2023) Improving the accuracy of blood pressure measuring devices in Australia: a modelled return on investment study. Journal of Human Hypertension, (doi: 10.1038/s41371-023-00866-2)

Murphy, C. N., Delles, C., Davies, E., Connelly, P. J. (2023) Cardiovascular disease in transgender individuals. Atherosclerosis, 384, (doi: 10.1016/j.atherosclerosis.2023.117282)

Martin, T. P., MacDonald, E. A., Bradley, A., Watson, H., Saxena, P., Rog-Zielinska, E. A., Raheem, A., Fisher, S., Elbassioni, A. A. M., Almuzaini, O., Booth, C., Campbell, M., Riddell, A., Herzyk, P., Blyth, K., Nixon, C., Zentilin, L., Berry, C., Braun, T., Giacca, M., McBride, M. W., Nicklin, S. R., Cameron, E. R., Loughrey, C. (2023) Ribonucleicacid interference or small molecule inhibition of Runx1 in the border zone prevents cardiac contractile dysfunction following myocardial infarction. Cardiovascular Research, 119, pp. 2663–2671-2663–2671. (doi: 10.1093/cvr/cvad107)

Irshad, Z., Lund, J., Sillars, A., Løvsletten, N. G., Gharanei, S., Salt, I. P., Freeman, D. J., Gill, J. M.R., Thoresen, G. H., Rustan, A. C., Zammit, V. A. (2023) The roles of DGAT1 and DGAT2 in human myotubes are dependent on donor patho-physiological background. FASEB Journal, 37, (doi: 10.1096/fj.202300960RR)

Glen, C., Adam, S., McDowell, K., Waterston, A., Tan, Y. Y., Petrie, M. C., Coats, C. J., Lang, N. N. (2023) Cardiotoxicity of BRAF/MEK inhibitors: a longitudinal study incorporating contemporary definitions and risk scores. JACC: CardioOncology, 5, pp. 628-637. (doi: 10.1016/j.jaccao.2023.04.004)

Jackson, A. M., Macartney, M., Brooksbank, K., Brown, C., Dawson, D., Francis, M., Japp, A., Lennie, V., Leslie, S. J., Martin, T., Neary, P., Venakatasubramanian, S., Vickers, D., Weir, R. A., McMurray, J. J.V., Jhund, P. S., Petrie, M. C. (2023) A 20-year population study of peripartum cardiomyopathy. European Heart Journal, (doi: 10.1093/eurheartj/ehad626)

Gulliver, C., Baillie, G. S., Hoffmann, R. (2023) Reduced PDE4D7 in prostate cancer correlates with genomic downregulation within the upstream PDE4D coding region. Future Science OA, 9, (doi: 10.2144/fsoa-2023-0064)

Parsons, E. C., Baillie, G. S., Hoffmann, R. (2023) Revisiting the roles of cAMP signalling in the progression of prostate cancer. Biochemical Journal, 480, pp. 1599-1614. (doi: 10.1042/BCJ20230297)

Meyer, B. J., Cortie, C., Dekker-Nitert, M., Barrett, H. L., Freeman, D. J. (2023) Women with gestational diabetes mellitus, controlled for plasma glucose level, exhibit maternal and fetal dyslipidaemia that may warrant treatment. Diabetes Research and Clinical Practice, 204, (doi: 10.1016/j.diabres.2023.110929)

Gulliver, C., Huss, S., Semjonow, A., Baillie, G. S., Hoffmann, R. (2023) Loss of PDE4D7 expression promotes androgen independence, neuroendocrine differentiation, and alterations in DNA repair: implications for therapeutic strategies. British Journal of Cancer, (doi: 10.1038/s41416-023-02417-5)

de Beer, D., MC. Mels, C., Schutte, A., Delles, C., Mary, S., Mullen, W., Mischak, H., Kruger, R. (2023) Urinary peptidomics and pulse wave velocity: The African-PREDICT study. Journal of Proteome Research, 22, pp. 3282-3289. (doi: 10.1021/acs.jproteome.3c00347)

Lucas-Herald, A. K., Montezano, A. C., Alves-Lopes, R., Haddow, L., O'Toole, S., Flett, M., Lee, B., Amjad, S. B., Steven, M., McNeilly, J., Brooksbank, K., Touyz, R. M., Ahmed, S. F. (2023) Effects of sex hormones on vascular reactivity in boys with hypospadias. Journal of Clinical Endocrinology and Metabolism, (doi: 10.1210/clinem/dgad525)

Wright, T. A., Gemmell, A. O., Tejeda, G. S., Blair, C. M., Baillie, G. S. (2023) Cancer: phosphodiesterase type 4C (PDE4C), the forgotten subfamily as a therapeutic target. International Journal of Biochemistry and Cell Biology, 162, (doi: 10.1016/j.biocel.2023.106453)

Sykes, R., Doherty, D., Morrow, A., Mangion, K., Rushd, A., Berry, C. (2023) NT-proBNP in patients presenting with myocardial infarction and non-obstructive coronary arteries without left ventricular systolic dysfunction. American Heart Journal Plus: Cardiology Research and Practice, 33, (doi: 10.1016/j.ahjo.2023.100311)

Keast, T., McErlane, J., Kearns, R., McKinlay, S., Raju, I., Watson, M., Robertson, K. E., Berry, C., Greenlaw, N., Ackland, G., McCall, P., Shelley, B. (2023) Study protocol for IMPRoVE: a multicentre prospective observational cohort study of the incidence, impact and mechanisms of perioperative right ventricular dysfunction in non-cardiac surgery. BMJ Open, 13, (doi: 10.1136/bmjopen-2023-074687)

Ranasinghe, S., Merz, C. N. B., Khan, N., Wei, J., George, M., Berry, C., Chieffo, A., Camici, P. G., Crea, F., Kaski, J. C., Marzilli, M., Gulati, M. (2023) Sex differences in Quality of Life in Patients with Ischemia with No Obstructive Coronary Artery Disease (INOCA): A Patient Self-Report Retrospective Survey from INOCA International. Journal of Clinical Medicine, 12, (doi: 10.3390/jcm12175646)

Bradley, C. P., Orchard, V., McKinley, G., Heggie, R., Wu, O., Good, R., Watkins, S., Lindsay, M., Eteiba, H., McGowan, J., McGeoch, R., Corcoran, D., Kellman, P., McConnachie, A., Berry, C. (2023) The coronary microvascular angina cardiovascular magnetic resonance imaging trial: rationale and design. American Heart Journal, (doi: 10.1016/j.ahj.2023.08.067)

Montezano, A. C., Camargo, L. L., Mary, S., Neves, K. B., Rios, F. J., Stein, R., Lopes, R. A., Beattie, W., Thomson, J., Herder, V., Szemiel, A. M., McFarlane, S., Palmarini, M., Touyz, R. (2023) SARS-CoV-2 spike protein induces endothelial inflammation via ACE2 independently of viral replication. Scientific Reports, 13, (doi: 10.1038/s41598-023-41115-3)

Berry, C., McClure, J. D., Oldroyd, K. (2023) Death at 5-years in the DEFINE-FLAIR and iFR-SWEDEHEART trials: a pooled analysis. European Heart Journal,

Yeoh, S. E., Osmanska, J., Petrie, M. C., Brooksbank, K. J.M., Clark, A. L., Docherty, K. F., Foley, P. W.X., Guha, K., Halliday, C. A., Jhund, P. S., Kalra, P. R., McKinley, G., Lang, N. N., Lee, M. M.Y., McConnachie, A., McDermott, J. J., Platz, E., Sartipy, P., Seed, A., Stanley, B., Weir, R. A.P., Welsh, P., McMurray, J. J.V., Campbell, R. T. (2023) Dapagliflozin versus metolazone in heart failure resistant to loop diuretics. European Heart Journal, 44, pp. 2966-2977. (doi: 10.1093/eurheartj/ehad341)

MacKenzie, S. M., Birch, L. A., Lamprou, S., Rezvanisanijouybari, P., Fayad, M., Zennaro, M.-C., Davies, E. (2023) MicroRNAs in aldosterone production and action. Elsevier

Mangion, K., Morrow, A. J., Sykes, R., Kamdar, A., Bagot, C., Bruce, G., Connelly, P., Delles, C., Gibson, V. B., Gillespie, L., Hall Barrientos, P., Lennie, V., Roditi, G., Sattar, N., Stobo, D., Allwood-Spiers, S., McConnachie, A., Berry, C., CISCO-19 investigators, (2023) Post-COVID-19 illness and associations with sex and gender. BMC Cardiovascular Disorders, 23, (doi: 10.1186/s12872-023-03412-7)

Ohashi, H. et al. (2023) Fractional flow reserve guided stent optimisation in focal and diffuse coronary artery disease. Diagnostics, 13, (doi: 10.3390/diagnostics13152612)

Rigattieri, S., Barbato, E., Berry, C. (2023) Microvascular resistance reserve: a reference test of the coronary microcirculation? European Heart Journal, 44, pp. 2870-2872. (doi: 10.1093/eurheartj/ehad291)

van de Vegte, Y. J. et al. (2023) Genetic insights into resting heart rate and its role in cardiovascular disease. Nature Communications, 14, (doi: 10.1038/s41467-023-39521-2)

Brown, C. E., Casey, H., Dominiczak, A. F., Kerr, S., Campbell, A., Delles, C. (2023) Impact of preeclampsia on cardiovascular events: an analysis of the Generation Scotland: Scottish family health study. Journal of Human Hypertension, 37, pp. 735-741. (doi: 10.1038/s41371-023-00812-2)

Sykes, R., Ang, D. T. Y., Berry, C. (2023) Invasive coronary microvascular function assessment: pharmacological versus exercise testing. Heart, 109, pp. 1130-1131. (doi: 10.1136/heartjnl-2023-322512)

Connelly, P. J., Delles, C. (2023) Journal of Human Hypertension special issue on sex and gender differences in hypertension. Journal of Human Hypertension, 37, pp. 587-588. (doi: 10.1038/s41371-023-00847-5)

Zorn, A., Baillie, G. (2023) Phosphodiesterase 7 as a therapeutic target – Where are we now? Cellular Signalling, 108, (doi: 10.1016/j.cellsig.2023.110689)

Casey, H., Dennehy, N., Fraser, A., Lees, C., McEniery, C. M., Scott, K., Wilkinson, I. B., Delles, C. (2023) Placental syndromes and maternal cardiovascular health. Clinical Science, 137, pp. 1211-1224. (doi: 10.1042/CS20211130)

Olivera, S., Graham, D. (2023) Sex differences in preclinical models of hypertension. Journal of Human Hypertension, 37, pp. 619-625. (doi: 10.1038/s41371-022-00770-1)

Bernhardt, J., Churilov, L., Dewey, H., Donnan, G., Ellery, F., English, C. K., Gao, L., Hayward, K. S., Horgan, F., Indredavik, B., Johns, H., Langhorne, P., Lindley, R., Martins, S., Mohd Ali, K., Middleton, S., Moodie, M., Pandian, J. D., Parsons, B., Robinson, T., Srikanth, V., Thijs, V. (2023) A phase III, multi-arm multi-stage covariate-adjusted response-adaptive randomized trial to determine optimal early mobility training after stroke (AVERT DOSE) International Journal of Stroke, 18, pp. 745-750. (doi: 10.1177/17474930221142207)

Lees, J. S., Dobbin, S. J.H., Elyan, B. M.P., Gilmour, D. F., Tomlinson, L. P., Lang, N. N., Mark, P. B. (2023) A systematic review and meta-analysis of the effect of intravitreal VEGF inhibitors on cardiorenal outcomes. Nephrology Dialysis Transplantation, 38, pp. 1666-1681. (doi: 10.1093/ndt/gfac305)

Paes, D., Schepers, M., Willems, E., Rombaut, B., Tiane, A., Solomina, Y., Tibbo, A., Blair, C., Kyurkchieva, E., Baillie, G. S., Ricciarelli, R., Brullo, C., Fedele, E., Bruno, O., van den Hove, D., Vanmierlo, T., Prickaerts, J. (2023) Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology. Cellular and Molecular Life Sciences, 80, (doi: 10.1007/s00018-023-04804-w)

Dowsett, L., Duluc, L., Higgins, E., Alghamdi, F., Fast, W., Salt, I. P., Leiper, J. (2023) Asymmetric dimethylarginine positively modulates calcium-sensing receptor signalling to promote lipid accumulation. Cellular Signalling, 107, (doi: 10.1016/j.cellsig.2023.110676)

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Lim, M. W.S., Setjiadi, D., Dobbin, S. J.H., Lang, N. N., Delles, C., Connelly, P. J. (2023) Nailfold video-capillaroscopy in the study of cardiovascular disease: a systematic review. Blood Pressure Monitoring, 28, pp. 24-32. (doi: 10.1097/MBP.0000000000000624)

Rushworth, L. K., Loveridge, C., Salji, M., MacLeod, M., Mui, E., Sumpton, D., Neilson, M., Hedley, A., Alexander, L., McCartney, E., Patel, R., Wallace, J., Delles, C., Jones, R., Leung, H. Y. (2023) Phase II proof of concept study of atorvastatin in castration resistant prostate cancer. BJU International, 131, pp. 236-243. (doi: 10.1111/bju.15851)

Chen, J. Y., Chew, K. S., Mary, S., Boder, P., Bagordo, D., Rossi, G. P., Touyz, R. M., Delles, C., Rossitto, G. (2023) Skin-specific mechanisms of body fluid regulation in hypertension. Clinical Science, 137, pp. 239-250. (doi: 10.1042/CS20220609)

Sharman, J. E., Ordunez, P., Brady, T., Parati, G., Stergiou, G., Whelton, P. K., Padwal, R., Olsen, M. H., Delles, C., Schutte, A. E., Tomaszewski, M., Lackland, D. T., Khan, N., McManus, R. J., Tsuyuki, R. T., Zhang, X.-H., Murphy, L. D., Moran, A. E., Schlaich, M. P., Campbell, N. R.C. (2023) The urgency to regulate validation of automated blood pressure measuring devices: a policy statement and call to action from the world hypertension league. Journal of Human Hypertension, 37, pp. 155-159. (doi: 10.1038/s41371-022-00747-0)

Artico, J. et al. (2023) Myocardial involvement after hospitalization for COVID-19 complicated by troponin elevation: a prospective, multicenter, observational study. Circulation, 147, pp. 364-374. (doi: 10.1161/CIRCULATIONAHA.122.060632)

Sykes, R. et al. (2023) Rationale and design of the effect of mineralocorticoid receptor antagonist therapy in patients with acute myocardial infarction or injury and non-obstructive coronary arteries: A registry-based, stratified-medicine, randomised, controlled trial. (doi: 10.1136/heartjnl-2022-BSCMR.26)

Sattar, N., Deanfield, J., Delles, C. (2023) Impact of intentional weight loss in cardiometabolic disease: what we know about timing of benefits on differing outcomes? Cardiovascular Research, (doi: 10.1093/cvr/cvac186)

Gulati, M., Khan, N., George, M., Berry, C., Chieffo, A., Camici, P. G., Crea, F., Kaski, J.-C., Marzilli, M., Merz, C. N. B. (2023) Ischemia with no obstructive coronary artery disease (INOCA): a patient self-report quality of life survey from INOCA international. International Journal of Cardiology, 371, pp. 28-39. (doi: 10.1016/j.ijcard.2022.09.047)

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Mizani, M. A., Dashtban, A., Pasea, L., Lai, A. G., Thygesen, J., Tomlinson, C., Handy, A., Mamza, J. B., Morris, T., Khalid, S., Zaccardi, F., Macleod, M. J., Torabi, F., Canoy, D., Akbari, A., Berry, C., Bolton, T., Nolan, J., Khunti, K., Denaxas, S., Hemingway, H., Sudlow, C., Banerjee, A. (2023) Using national electronic health records for pandemic preparedness: validation of a parsimonious model for predicting excess deaths among those with COVID-19–a data-driven retrospective cohort study. Journal of the Royal Society of Medicine, 116, pp. 10-20. (doi: 10.1177/01410768221131897)

Cameron, T. M., Koller, K., Byrne, A., Chouliara, N., Robinson, T., Langhorne, P., Walker, M., Fisher, R. J. (2023) A qualitative study exploring how stroke survivors' expectations and understanding of stroke Early Supported Discharge shaped their experience and engagement with the service. Disability and Rehabilitation, 45, pp. 2604-2611. (doi: 10.1080/09638288.2022.2102251)

Padmanabhan, S., Du Toit, C., Dominiczak, A. F. (2023) Cardiovascular precision medicine – a pharmacogenomic perspective. Cambridge Prisms: Precision Medicine, 1, pp. 1-54. (doi: 10.1017/pcm.2023.17)

Taylor, A., Cushing, A., Dow, M., Anderson, J., McDowell, G., Lua, S., Manthe, M., Padmanabhan, S., Burns, S., McGinness, P., Lowe, D. J., Carlin, C. (2023) Long-term usage and improved clinical outcomes with adoption of a COPD digital support service: key findings from the RECEIVER trial. International Journal of Chronic Obstructive Pulmonary Disease, 18, pp. 1301-1318. (doi: 10.2147/COPD.S409116)

Kulkarni, S., Glover, M., Kapil, V., Abrams, S. M. L., Partridge, S., McCormack, T., Sever, P., Delles, C., Wilkinson, I. B. (2023) Management of hypertensive crisis: British and Irish Hypertension Society position document. Journal of Human Hypertension, (doi: 10.1038/s41371-022-00776-9)

2022

Collet, C., Collison, D., Mizukami, T., McCartney, P., Sonck, J., Ford, T., Munhoz, D., Berry, C., De Bruyne, B., Oldroyd, K. (2022) Differential improvement in angina and health-related quality of life after PCI in focal and diffuse coronary artery disease. JACC: Cardiovascular Interventions, 15, pp. 2506-2518. (doi: 10.1016/j.jcin.2022.09.048)

Kumluang, S., Geue, C., Langhorne, P., Wu, O. (2022) Availability of stroke services and hospital facilities at different hospital levels in Thailand: a cross-sectional survey study. BMC Health Services Research, 22, (doi: 10.1186/s12913-022-08922-2)

Kalra, P. R., Cleland, J. G.F., Petrie, M. C., Thomson, E. A., Kalra, P. A., Squire, I. B., Ahmed, F. Z., Al-Mohammad, A., Cowburn, P. J., Foley, P. W.X., Graham, F. J., Japp, A. G., Lane, R. E., Lang, N. N., Ludman, A. J., Macdougall, I. C., Pellicori, P., Ray, R., Robertson, M., Seed, A., Ford, I. (2022) Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial. Lancet, 400, pp. 2199-2209. (doi: 10.1016/S0140-6736(22)02083-9)

Murray, E. C., Delles, C., Orzechowski, P., Renc, P., Sitek, A., Wagenaar, J., Guzik, T. J. (2022) Vascular phenotypes in early hypertension. Journal of Human Hypertension, (doi: 10.1038/s41371-022-00794-7)

McGettrick, M., Dormand, H., Brewis, M., Johnson, M. K., Lang, N. N., Church, A. C. (2022) Cardiac geometry, as assessed by cardiac magnetic resonance, can differentiate subtypes of chronic thromboembolic pulmonary vascular disease. Frontiers in Cardiovascular Medicine, 9, (doi: 10.3389/fcvm.2022.1004169)

Gerganova, G., Riddell, A., Miller, A. A. (2022) CNS border-associated macrophages in the homeostatic and ischaemic brain. Pharmacology and Therapeutics, 240, (doi: 10.1016/j.pharmthera.2022.108220)

Mark, P. B., Mangion, K., Rankin, A. J., Rutherford, E., Lang, N. N., Petrie, M. C., Stoumpos, S., Patel, R. K. (2022) Left ventricular dysfunction with preserved ejection fraction: the most common left ventricular disorder in chronic kidney disease patients. Clinical Kidney Journal, 15, pp. 2186-2199. (doi: 10.1093/ckj/sfac146)

Rossitto, G., Delles, C. (2022) Mechanisms of sodium-mediated injury in cardiovascular disease: old play, new scripts. FEBS Journal, 289, pp. 7260-7273. (doi: 10.1111/febs.16155)

de Wit, S., Glen, C., de Boer, R. A., Lang, N. N. (2022) Mechanisms shared between cancer, heart failure, and targeted anti-cancer therapies. Cardiovascular Research, 118, pp. 3451-3466. (doi: 10.1093/cvr/cvac132)

Suda, A., Takahashi, J., Schwidder, M., Ong, P., Ang, D., Berry, C., Camici, P. G., Crea, F., Carlos Kaski, J., Pepine, C., Rimoldi, O., Sechtem, U., Yasuda, S., Beltrame, J. F., Noel Bairey Merz, C., Shimokawa, H., Coronary Vasomotor Disorders International Study COVADIS Group, . (2022) Prognostic association of plasma NT-proBNP levels in patients with microvascular angina -A report from the international cohort study by COVADIS- International Journal of Cardiology: Heart and Vasculature, 43, (doi: 10.1016/j.ijcha.2022.101139)

Kalra, P. R., Cleland, J. G. F., Petrie, M. C., Ahmed, F. Z., Foley, P. W. X., Kalra, P. A., Lang, N. N., Lane, R. E., Macdougall, I. C., Pellicori, P., Pope, M. T. B., Robertson, M., Squire, I. B., Thomson, E. A., Ford, I. (2022) Rationale and design of a randomised trial of intravenous iron in patients with heart failure. Heart, 108, pp. 1979-1985. (doi: 10.1136/heartjnl-2022-321304)

Bradley, C., Berry, C. (2022) Retinal microvascular function: a tractable biomarker of cardiovascular risk? Cardiovascular Research, 118, pp. 3169-3170. (doi: 10.1093/cvr/cvac170)

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Connelly, P. J., Casey, H., Montezano, A. C., Touyz, R. M., Delles, C. (2022) Sex steroids receptors, hypertension and vascular ageing. Journal of Human Hypertension, 36, pp. 120-125. (doi: 10.1038/s41371-021-00576-7)

Ciminata, G., Geue, C., Wu, O., Deidda, M., Kreif, N., Langhorne, P. (2022) Propensity score methods for comparative-effectiveness analysis: a case study of direct oral anticoagulants in the atrial fibrillation population. PLoS ONE, 17, (doi: 10.1371/journal.pone.0262293)

Herrmann, J. et al. (2022) Defining cardiovascular toxicities of cancer therapies: an International Cardio-Oncology Society (IC-OS) consensus statement. European Heart Journal, 43, pp. 280-299. (doi: 10.1093/eurheartj/ehab674)

Smyth, A., O’Donnell, M., Hankey, G. J., Rangarajan, S., Lopez-Jaramillo, P., Xavier, D., Zhang, H., Canavan, M., Damasceno, A., Langhorne, P., Avezum, A., Pogosova, N., Oguz, A., Yusuf, S. (2022) Anger or emotional upset and heavy physical exertion as triggers of stroke: the INTERSTROKE study. European Heart Journal, 43, pp. 202-209. (doi: 10.1093/eurheartj/ehab738)

Delles, C. (2022) Maternally inherited essential hypertension: adding further complexity to an already complex condition. American Journal of Hypertension, 35, pp. 16-18. (doi: 10.1093/ajh/hpab133)

Moudio, S., Willis, A., Pytka, K., Abulkassim, R., Brett, R. R., Webster, J. F., Wozny, C., Barbour, M., Jiang, H.-R., Watson, D. G., van Kralingen, J. C., MacKenzie, S. M., Daniels, M., McColl, B. W., Sossick, S., Nuthall, H. N., Bushell, T. J. (2022) Protease-activated receptor 2 activation induces behavioural changes associated with depression-like behaviour through microglial-independent modulation of inflammatory cytokines. Psychopharmacology, 239, pp. 229-242. (doi: 10.1007/s00213-021-06040-1)

Baillie, G., Kyurkchieva, E., Sin, Y. Y., Ahmed, F., Rajapakse, N., Schoolmeesters, A., Richard, N., Erdman, P., Hecht, D., Chourasia, A. H., Mercurio, F., Fung, L., Chan, K., Stirling, D. (2022) Evaluating the Utility of Bi-functional Degrader Molecules for Selective Inhibition of PDE4 In Acrodysostosis Type2.

Dekkers, R., Carey, L., Langhorne, P. (2022) Making Literature Reviews Work: A Multidisciplinary Guide to Systematic Approaches. Springer

Delles, C., Rossitto, G. (2022) Of snails, earthworms, and men: insights into strategies to preserve water. Function, 3, (doi: 10.1093/function/zqab071)

Morrow, A., Gray, S. R., Bayes, H. K., Sykes, R., McGarry, E., Anderson, D., Boiskin, D., Burke, C., Cleland, J. G. F., Goodyear, C., Ibbotson, T., Lang, C. C., McConnachie, A., Mair, F., Mangion, K., Patel, M., Sattar, N., Taggart, D., Taylor, R., Dawkes, S., Berry, C. (2022) Prevention and early treatment of the long-term physical effects of COVID-19 in adults: design of a randomised controlled trial of resistance exercise—CISCO-21. Trials, 23, (doi: 10.1186/s13063-022-06632-y)

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Armignacco, R. et al. (2022) Whole blood methylome-derived features to discriminate endocrine hypertension. Clinical Epigenetics, 14, (doi: 10.1186/s13148-022-01347-y)

2021

Connelly, P. J., Delles, C. (2021) Cardiovascular disease in transgender people: recent research and emerging evidence. Cardiovascular Research, 117, pp. e174-e176. (doi: 10.1093/cvr/cvab288)

Collison, D., Didagelos, M., Aetesam-Ur-Rahman, M., Copt, S., McDade, R., McCartney, P., Ford, T. J., McClure, J., Lindsay, M., Shaukat, A., Rocchiccioli, P., Brogan, R., Watkins, S., McEntegart, M., Good, R., Robertson, K., O’Boyle, P., Davie, A., Khan, A., Hood, S., Eteiba, H., Berry, C., Oldroyd, K. G. (2021) Post-stenting fractional flow reserve vs coronary angiography for optimization of percutaneous coronary intervention (TARGET-FFR) European Heart Journal, 42, pp. 4656-4668. (doi: 10.1093/eurheartj/ehab449)

Trivett, C., Lees, Z. J., Freeman, D. J. (2021) Adipose tissue function in healthy pregnancy, gestational diabetes mellitus and pre-eclampsia. European Journal of Clinical Nutrition, 75, pp. 1745-1756. (doi: 10.1038/s41430-021-00948-9)

Lang, N. N., Touyz, R. M. (2021) Mechanistic science in cardiovascular-oncology: the way forward to maximise anti-cancer drug effects and minimise cardiovascular toxicity. Clinical Science, 135, pp. 2661-2663. (doi: 10.1042/CS20210986)

Keenan, N. G., Captur, G., McCann, G. P., Berry, C., Myerson, S. G., Fairbairn, T., Hudsmith, L., O'Regan, D. P., Westwood, M., Greenwood, J. P. (2021) Regional variation in cardiovascular magnetic resonance service delivery across the UK. Heart, 107, pp. 1974-1979. (doi: 10.1136/heartjnl-2020-318667)

Mary, S., Boder, P., Rossitto, G., Graham, L., Scott, K., Flynn, A., Kipgen, D., Graham, D., Delles, C. (2021) Salt loading decreases urinary excretion and increases intracellular accumulation of uromodulin in stroke-prone spontaneously hypertensive rats. Clinical Science, 135, pp. 2749-2761. (doi: 10.1042/CS20211017)

Mahindra, A., Tejeda, G., Rossi, M., Janha, O., Herbert, I., Morris, C., Morgan, D. C., Beattie, W., Montezano, A. C., Hudson, B., Tobin, A. B., Bhella, D., Touyz, R. M., Jamieson, A. G., Baillie, G. S., Blair, C. M. (2021) Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction. PLoS ONE, 16, (doi: 10.1371/journal.pone.0260283)

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Rankin, A. J., Mangion, K., Lees, J. S., Rutherford, E., Gillis, K. A., Edy, E., Dymock, L., Treibel, T. A., Radjenovic, A., Patel, R. K., Berry, C., Roditi, G., Mark, P. B. (2021) Myocardial changes on 3T cardiovascular magnetic resonance imaging in response to haemodialysis with fluid removal. Journal of Cardiovascular Magnetic Resonance, 23, (doi: 10.1186/s12968-021-00822-4)

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Morrow, A. et al. (2021) Rationale and design of the Medical Research Council Precision medicine with Zibotentan in microvascular angina (PRIZE) trial MRI sub-study. (doi: 10.1136/heartjnl-2021-BSCMR.3)

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Fisher, R. J., Chouliara, N., Byrne, A., Cameron, T., Lewis, S., Langhorne, P., Robinson, T., Waring, J., Geue, C., Paley, L., Rudd, A., Walker, M. F. (2021) Large-scale implementation of stroke early supported discharge: the WISE realist mixed-methods study. Health Services and Delivery Research, 9, (doi: 10.3310/hsdr09220)

He, T. et al. (2021) Urinary peptides in heart failure: a link to molecular pathophysiology. European Journal of Heart Failure, 23, pp. 1875-1887. (doi: 10.1002/ejhf.2195)

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Curzen, N. et al. (2021) Fractional flow reserve derived from computed tomography coronary angiography in the assessment and management of stable chest pain: the FORECAST randomized trial. European Heart Journal, 42, pp. 3844-3852. (doi: 10.1093/eurheartj/ehab444)

Touyz, R. M., Boyd, M. O.E., Guzik, T., Padmanabhan, S., McCallum, L., Delles, C., Mark, P. B., Petrie, J. R., Rios, F., Montezano, A. C., Sykes, R., Berry, C. (2021) Cardiovascular and renal risk factors and complications associated with COVID-19. CJC Open, 3, pp. 1257-1272. (doi: 10.1016/j.cjco.2021.05.020)

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Raafs, A. et al. (2021) Identification of sex‐specific biomarkers predicting new‐onset heart failure. ESC Heart Failure, 8, pp. 3512-3520. (doi: 10.1002/ehf2.13476)

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Anderson, J. J., Ho, F. K., Niedzwiedz, C. L., Katikireddi, V., Celis-Morales, C., Iliodromiti, S., Welsh, P., Pellicori, P., Demou, E., Hastie, C. E., Lyall, D. M., Gray, S. R., Forbes, J. F., Gill, J. M.R., Mackay, D. F., Berry, C., Cleland, J. G.F., Sattar, N., Pell, J. P. (2021) Remote history of VTE is associated with severe COVID-19 in middle and older age: UK Biobank cohort study. Journal of Thrombosis and Haemostasis, 19, pp. 2533-2538. (doi: 10.1111/jth.15452)

Ho, F. K., Man, K. K.S., Toshner, M., Church, C., Celis-Morales, C., Wong, I. C.K., Berry, C., Sattar, N., Pell, J. P. (2021) Thromboembolic risk in hospitalised and non-hospitalised Covid-19 patients: a self-controlled case series analysis of a nation-wide cohort. Mayo Clinic Proceedings, 96, pp. 2587-2597. (doi: 10.1016/j.mayocp.2021.07.002)

MacDonald, E. A., Quinn, T. A. (2021) What keeps us ticking? Sinoatrial node mechano-sensitivity: the grandfather clock of cardiac rhythm. Biophysical Reviews, 13, pp. 707-716. (doi: 10.1007/s12551-021-00831-8)

Docherty, N. G., Delles, C., D’Haese, P., Layton, A. T., Martínez-Salgado, C., Vervaet, B. A., López-Hernández, F. J. (2021) Haemodynamic frailty – A risk factor for acute kidney injury in the elderly. Ageing Research Reviews, 70, (doi: 10.1016/j.arr.2021.101408)

Buist, H. K., Luchowska-Stańska, U., van Basten, B., Valli, J., Smith, B. O., Baillie, G. S., Rickman, C., Ricketts, B., Davidson, A., Hannam, R., Sunderland, J., Yarwood, S. J. (2021) Identification and characterization of an affimer affinity reagent for the detection of the cAMP sensor, EPAC1. Cells, 10, (doi: 10.3390/cells10092307)

Sigfrid, L. et al. (2021) Long Covid in adults discharged from UK hospitals after Covid-19: a prospective, multicentre cohort study using the ISARIC WHO Clinical Characterisation Protocol. Lancet Regional Health - Europe, 8, (doi: 10.1016/j.lanepe.2021.100186)

Romaszko, L., Borowska, A., Lazarus, A., Dalton, D., Berry, C., Luo, X., Husmeier, D., Gao, H. (2021) Neural network-based left ventricle geometry prediction from CMR images with application in biomechanics. Artificial Intelligence In Medicine, 119, (doi: 10.1016/j.artmed.2021.102140)

Alexander, J., Langhorne, P., Kidd, L., Wu, O., McConnachie, A., van Wijck, F., Dawson, J. (2021) SaeboGlove therapy for upper limb disability and severe hand impairment after stroke (SUSHI): study protocol for a randomised controlled trial. European Stroke Journal, 6, pp. 302-310. (doi: 10.1177/23969873211036586)

Alves-Lopes, R., Montezano, A. C., Neves, K. B., Harvey, A., Rios, F. J., Skiba, D. S., Arendse, L. B., Guzik, T. J., Graham, D., Poglitsch, M., Sturrock, E., Touyz, R. M. (2021) Selective inhibition of the C-domain of ACE (angiotensin-converting enzyme) combined with inhibition of NEP (neprilysin): a potential new therapy for hypertension. Hypertension, 78, pp. 604-616. (doi: 10.1161/HYPERTENSIONAHA.121.17041)

Heggie, R., Briggs, A., Stanley, B., Good, R., Rocchiccioli, P., McEntegart, M., Watkins, S., Eteiba, H., Shaukat, A., Lindsay, M., Robertson, K., Hood, S., McGeoch, R., McDade, R., YII, E., Collison, D., Oldroyd, K., Ford, T. J., Berry, C. (2021) Stratified medicine using invasive coronary function testing in angina: a cost-effectiveness analysis of the British Heart Foundation CorMicA trial. International Journal of Cardiology, 337, pp. 44-51. (doi: 10.1016/j.ijcard.2021.05.016)

Boder, P., Mary, S., Mark, P. B., Leiper, J., Dominiczak, A. F., Padmanabhan, S., Rampold, L., Delles, C. (2021) Mechanistic interactions of uromodulin with the thick ascending limb: perspectives in physiology and hypertension. Journal of Hypertension, 39, pp. 1490-1504. (doi: 10.1097/HJH.0000000000002861)

Clarke, T.-K., Adams, M. J., Howard, D. M., Xia, C., Davies, G., Hayward, C., Campbell, A., Padmanabhan, S., Smith, B. H., Murray, A., Porteous, D., Deary, I. J., McIntosh, A. M. (2021) Genetic and shared couple environmental contributions to smoking and alcohol use in the UK population. Molecular Psychiatry, 26, pp. 4344-4354. (doi: 10.1038/s41380-019-0607-x)

Bates, E. A., Counsell, J. R., Alizert, S., Baker, A. T., Suff, N., Boyle, A., Bradshaw, A. C., Waddington, S. N., Nicklin, S. A., Baker, A. H., Parker, A. L. (2021) In vitro and in vivo evaluation of human adenovirus type 49 as a vector for therapeutic applications. Viruses, 13, (doi: 10.3390/v13081483)

Lees, J. S., Ho, F., Parra -Soto, S., Celis-Morales, C., Welsh, P., Sullivan, M. K., Jani, B. D., Sattar, N., Lang, N. N., Pell, J. P., Webster, A. C., Mark, P. B. (2021) Kidney function and cancer risk: an analysis using creatinine and cystatin C in a cohort study. EClinicalMedicine, 38, (doi: 10.1016/j.eclinm.2021.101030)

Patanapirunhakit, P., Karlsson, H., Mulder, M., Ljunggren, S., Graham, D., Freeman, D. (2021) Sphingolipids in HDL – potential markers for adaptation to pregnancy? Biochimica et Biophysica Acta: Molecular and Cell Biology of Lipids, 1866, (doi: 10.1016/j.bbalip.2021.158955)

Docherty, K. F., Campbell, R. T., Brooksbank, K. J.M., Dreisbach, J. G., Forsyth, P., Godeseth, R., Hopkins, T., Jackson, A. M., Lee, M. M.Y., McConnachie, A., Roditi, G., Squire, I. B., Stanley, B., Welsh, P., Jhund, P. S., Petrie, M., McMurray, J. J.V. (2021) The effect of neprilysin inhibition on left ventricular remodeling in patients with asymptomatic left ventricular systolic dysfunction late after myocardial infarction. Circulation, 144, pp. 199-209. (doi: 10.1161/CIRCULATIONAHA.121.054892)

Noh, R. M., Graveling, A. J., Lang, N. N., White, A. C., Lee, K. K., Mills, N. L., Newby, D. E., Lang, C. C., Frier, B. M. (2021) Effect of hypoglycaemia on measures of myocardial blood flow and myocardial injury in adults with and without type 1 diabetes: a prospective, randomised, open-label, blinded endpoint, cross-over study. Endocrinology, Diabetes and Metabolism, 4, (doi: 10.1002/edm2.258)

Lang, N. N., Ahmad, F. A., Cleland, J. G., O'Connor, C. M., Teerlink, J. R., Voors, A. A., Taubel, J., Hodes, A. R., Anwar, M., Karra, R., Sakata, Y., Ishihara, S., Senior, R., Khemka, A., Prasad, N. G., DeSouza, M. M., Seiffert, D., Ye, J. Y., Kessler, P. D., Borentain, M., Solomon, S. D., Felker, G. M., McMurray, J. J.V. (2021) Haemodynamic effects of the nitroxyl donor cimlanod (BMS-986231) in chronic heart failure: a randomized trial. European Journal of Heart Failure, 23, pp. 1147-1155. (doi: 10.1002/ejhf.2138)

Morgan, D. C., Morris, C., Mahindra, A., Blair, C. M., Tejeda, G., Herbert, I., Turnbull, M. L., Lieber, G., Willett, B. J., Logan, N., Smith, B., Tobin, A. B., Bhella, D., Baillie, G. S., Jamieson, A. G. (2021) Stapled ACE2 peptidomimetics designed to target the SARS-CoV-2 spike protein do not prevent virus internalisation. Peptide Science, 113, (doi: 10.1002/pep2.24217)

Anand, A., Lee, K. K., Chapman, A. R., Ferry, A. V., Adamson, P. D., Strachan, F. E., Berry, C., Findlay, I., Cruikshank, A., Reid, A., Collinson, P. O., Apple, F. S., McAllister, D., Maguire, D., Fox, K. A.A., Newby, D. E., Tuck, C., Harkess, R., Keerie, C., Weir, C. J., Parker, R. A., Gray, A., Shah, A. S.V., Mills, N. (2021) High-sensitivity cardiac troponin on presentation to rule out myocardial infarction: a stepped-wedge cluster randomized controlled trial. Circulation, 143, pp. 2214-2224. (doi: 10.1161/CIRCULATIONAHA.120.052380)

Murray, E., Rossitto, G., Delles, C. (2021) Haemodynamic assessment in hypertension: the soloists and the orchestra. Journal of Hypertension, 39, pp. 1109-1111. (doi: 10.1097/HJH.0000000000002796)

Mary, S., Small, H., Herse, F., Carrick, E., Flynn, A., Mullen, W., Dechend, R., Delles, C. (2021) Pre-existing hypertension and pregnancy induced hypertension reveal molecular differences in placental proteome in rodents. Physiological Genomics, 53, pp. 259-268. (doi: 10.1152/physiolgenomics.00160.2020)

Chen, J. et al. (2021) The trans-ancestral genomic architecture of glycemic traits. Nature Genetics, 53, pp. 840-860. (doi: 10.1038/s41588-021-00852-9)

Maznyczka, A. M., Carrick, D., Oldroyd, K. G., James-Rae, G., McCartney, P., Greenwood, J. P., Good, R., McEntegart, M., Eteiba, H., Lindsay, M., Cotton, J. M., Petrie, M. C., Berry, C. (2021) Thermodilution-derived temperature recovery time, a novel predictor of microvascular reperfusion and prognosis after myocardial infarction. EuroIntervention, 17, pp. 220-228. (doi: 10.4244/EIJ-D-19-00904)

Fawcett, K. A. et al. (2021) Variants associated with HHIP expression have sex-differential effects on lung function. Wellcome Open Research, 5, (doi: 10.12688/wellcomeopenres.15846.2)

Rossitto, G., Maiolino, G., Lerco, S., Ceolotto, G., Blackburn, G., Mary, S., Antonelli, G., Berton, C., Bisogni, V., Cesari, M., Seccia, T. M., Lenzini, L., Pinato, A., Montezano, A., Touyz, R. M., Petrie, M. C., Daly, R., Welsh, P., Plebani, M., Rossi, G. P., Delles, C. (2021) High sodium intake, glomerular hyperfiltration and protein catabolism in patients with essential hypertension. Cardiovascular Research, 117, pp. 1372-1381. (doi: 10.1093/cvr/cvaa205)

Heath Richardson, S. I., Gao, H., Cox, J., Janiczek, R., Griffith, B. E., Berry, C., Luo, X. (2021) A poroelastic immersed finite element framework for modeling cardiac perfusion and fluid-structure interaction. International Journal for Numerical Methods in Biomedical Engineering, 37, (doi: 10.1002/cnm.3446)

Connelly, P. J., Azizi, Z., Alipour, P., Delles, C., Pilote, L., Raparelli, V. (2021) The importance of gender to understand sex differences in cardiovascular disease. Canadian Journal of Cardiology, 37, pp. 699-710. (doi: 10.1016/j.cjca.2021.02.005)

Shaw, R. J., Mackay, D., Pell, J. P., Padmanabhan, S., Bailey, D. S., Smith, D. J. (2021) The relationship between antihypertensive medications and mood disorders: analysis of linked healthcare data for 1.8 million patients. Psychological Medicine, 51, pp. 1183-1191. (doi: 10.1017/S0033291719004094)

Mooney, L., Goodyear, C. S., Chandra, T., Kirschner, K., Copland, M., Petrie, M. C., Lang, N. N. (2021) Clonal haematopoiesis of indeterminate potential: intersections between inflammation, vascular disease and heart failure. Clinical Science, 135, pp. 991-1007. (doi: 10.1042/CS20200306)

Vlahou, A. et al. (2021) Data sharing under the General Data Protection Regulation: time to harmonize law and research ethics? Hypertension, 77, pp. 1029-1035. (doi: 10.1161/HYPERTENSIONAHA.120.16340)

Scott, K., Morgan, H. L., Delles, C., Fisher, S., Graham, D., McBride, M. W. (2021) Distinct uterine artery gene expression profiles during early gestation in the stroke-prone spontaneously hypertensive rat. Physiological Genomics, 53, pp. 160-171. (doi: 10.1152/physiolgenomics.00159.2020)

Padmanabhan, S., Dominiczak, A. F. (2021) Genomics of hypertension: the road to precision medicine. Nature Reviews Cardiology, 18, pp. 235-250. (doi: 10.1038/s41569-020-00466-4)

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Briscoe, M., Sykes, R., Krystofiak, T., Peck, O., Mangion, K., Berry, C. (2021) Clinical significance of coronavirus disease 2019 in hospitalized patients with myocardial injury. Clinical Cardiology, 44, pp. 332-339. (doi: 10.1002/clc.23530)

Crouch, S. H., Botha-Le Roux, S., Delles, C., Graham, L. A., Schutte, A. E. (2021) Inflammation and salt in young adults: the African-PREDICT study. European Journal of Nutrition, 60, pp. 873-882. (doi: 10.1007/s00394-020-02292-3)

Sykes, R. A., Mohamed, M. O., Kwok, C. S., Mamas, M. A., Berry, C. (2021) Percutaneous coronary intervention and 30-day unplanned readmission with chest pain in the United States (nationwide readmissions database) Clinical Cardiology, 44, pp. 291-306. (doi: 10.1002/clc.23543)

Neves, K. B., Morris, H., Alves-Lopes, R., Muir, K. W., Moreton, F., Delles, C., Montezano, A. C., Touyz, R. M. (2021) Peripheral arteriopathy caused by Notch3 gain-of-function mutation involves ER and oxidative stress and blunting of NO∕sGC∕cGMP pathway. Clinical Science, 135, pp. 753-773. (doi: 10.1042/CS20201412)

Doherty, D. J., Sykes, R., Mangion, K., Berry, C. (2021) Predictors of microvascular reperfusion after myocardial infarction. Current Cardiology Reports, 23, (doi: 10.1007/s11886-021-01442-1)

Drozdowska, B. A., McGill, K., McKay, M., Bartlam, R., Langhorne, P., Quinn, T. J. (2021) Prognostic rules for predicting cognitive syndromes following stroke: a systematic review. European Stroke Journal, 6, pp. 18-27. (doi: 10.1177/2396987321997045)

Cameron, A. C., Neves, K. B., White, J., Touyz, R. M., Lang, N. N. (2021) Reply: Cisplatin-associated aortic thrombosis: a review of cases reported to the FDA adverse event reporting system. JACC: CardioOncology, 3, pp. 166. (doi: 10.1016/j.jaccao.2021.01.005)

Lee, M. M.Y. et al. (2021) Invasive versus medically managed acute coronary syndromes with prior bypass (CABG-ACS): insights into the registry versus randomised trial populations. Open Heart, 8, (doi: 10.1136/openhrt-2020-001453)

Ehteshami-Afshar, S., Mooney, L., Dewan, P., Desai, A. S., Lang, N. N., Lefkowitz, M. P., Petrie, M. C., Rizkala, A. R., Rouleau, J. L., Solomon, S. D., Swedberg, K., Shi, V. C., Zile, M. R., Packer, M., McMurray, J. J.V., Jhund, P. S., Hawkins, N. M. (2021) Clinical characteristics and outcomes of patients with heart failure with reduced ejection fraction and chronic obstructive pulmonary disease: insights from PARADIGM-HF. Journal of the American Heart Association, 10, (doi: 10.1161/JAHA.120.019238)

Lee, M. M.Y. et al. (2021) Effect of empagliflozin on left ventricular volumes in patients with type 2 diabetes, or prediabetes, and heart failure with reduced ejection fraction (SUGAR-DM-HF) Circulation, 143, pp. 516-525. (doi: 10.1161/CIRCULATIONAHA.120.052186)

Petrie, M. C., Lee, M. M., Lang, N. N. (2021) EMPEROR-REDUCED reigns while EMPERIAL whimpers. European Heart Journal, 42, pp. 711-714. (doi: 10.1093/eurheartj/ehaa965)

Li, W., Gao, H., Mangion, K., Berry, C., Luo, X. (2021) Apparent growth tensor of left ventricular post myocardial infarction – in human first natural history study. Computers in Biology and Medicine, 129, (doi: 10.1016/j.compbiomed.2020.104168)

Maznyczka, A. M., McCartney, P., Duklas, P., McEntegart, M., Oldroyd, K., Greenwood, J., Muir, D., Chowdhary, S., Gershlick, A. H., Eteiba, H., Cotton, J., Wragg, A., Curzen, N., Tait, R., Macfarlane, P., Welsh, P., Sattar, N., Petrie, M., Ford, I., Fox, K., McConnachie, A., Berry, C. (2021) Effect of coronary flow on intracoronary alteplase: a prespecified analysis from a randomised trial. Heart, 107, pp. 299-312. (doi: 10.1136/heartjnl-2020-317828)

Felker, G. M. et al. (2021) Effects of a novel nitroxyl donor in acute heart failure: the STAND-UP AHF Study. JACC: Heart Failure, 9, pp. 146-157. (doi: 10.1016/j.jchf.2020.10.012)

Schnabel, S., van Wijck, F., Bain, B., Barber, M., Dall, P., Fleming, A., Kerr, A., Langhorne, P., McConnachie, A., Molloy, K., Stanley, B., Young, H., Kidd, L. (2021) Experiences of augmented arm rehabilitation including supported self-management after stroke: a qualitative investigation. Clinical Rehabilitation, 35, pp. 288-301. (doi: 10.1177/0269215520956388)

Docherty, K. F., Campbell, R. T., Brooksbank, K. J.M., Godeseth, R. L., Forsyth, P., McConnachie, A., Roditi, G., Stanley, B., Welsh, P., Jhund, P. S., Petrie, M. C., McMurray, J. J.V. (2021) Rationale and methods of a randomized trial evaluating the effect of neprilysin inhibition on left ventricular remodelling. ESC Heart Failure, 8, pp. 129-138. (doi: 10.1002/ehf2.13137)

Maznyczka, A. M., McCartney, P. J., Oldroyd, K. G., Lindsay, M., McEntegart, M., Eteiba, H., Rocchiccioli, J. P., Good, R., Shaukat, A., Robertson, K., Malkin, C. J., Greenwood, J. P., Cotton, J. M., Hood, S., Watkins, S., Collison, D., Gillespie, L., Ford, T. J., Weir, R. A.P., McConnachie, A., Berry, C. (2021) Risk stratification guided by the index of microcirculatory resistance and left ventricular end-diastolic pressure in acute myocardial infarction. Circulation: Cardiovascular Interventions, 14, (doi: 10.1161/CIRCINTERVENTIONS.120.009529)

Baillie, G. S., Gulliver, C., Hoffmann, R. (2021) The enigmatic helicase DHX9 and its association with the hallmarks of cancer. Future Science OA, 7, (doi: 10.2144/fsoa-2020-0140)

Connelly, P. J., Clark, A., Touyz, R. M., Delles, C. (2021) Transgender adults, gender-affirming hormone therapy and blood pressure: a systematic review. Journal of Hypertension, 39, pp. 223-230. (doi: 10.1097/HJH.0000000000002632)

Corcoran, D., Radjenovic, A., Mordi, I., Nazir, S. A., Wilson, S. J., Hinder, M., Yates, D. P., Machineni, S., Alcantara, J., Prescott, M. F., Gugliotta, B., Pang, Y., Tzemos, N., Semple, S. I., Newby, D. E., McCann, G. P., Squire, I., Berry, C. (2021) Vascular effects of serelaxin in patients with stable coronary artery disease: a randomized placebo-controlled trial. Cardiovascular Research, 117, pp. 320-329. (doi: 10.1093/cvr/cvz345)

Moreton, F. C., Cullen, B., Dickie, D. A., Lopez Gonzalez, R., Santosh, C., Delles, C., Muir, K. W. (2021) Brain imaging factors associated with progression of subcortical hyperintensities in CADASIL over two year follow up. European Journal of Neurology, 28, pp. 220-228. (doi: 10.1111/ene.14534)

Dobbin, S. J.H., Petrie, M. C., Myles, R. C., Touyz, R. M., Lang, N. N. (2021) Cardiotoxic effects of angiogenesis inhibitors. Clinical Science, 135, pp. 71-100. (doi: 10.1042/CS20200305)

Fisher, R. J., Byrne, A., Chouliara, N., Lewis, S., Paley, L., Hoffman, A., Rudd, A., Robinson, T., Langhorne, P., Walker, M. (2021) Effect of stroke early supported discharge on length of hospital stay: analysis from a national stroke registry. BMJ Open, 11, (doi: 10.1136/bmjopen-2020-043480)

McCallum, L., Brooksbank, K., McConnachie, A., Aman, A., Lip, S., Dawson, J., MacIntyre, I. M., MacDonald, T. M., Webb, D. J., Padmanabhan, S. (2021) Rationale and design of the genotype-blinded trial of torasemide for the treatment of hypertension (BHF UMOD) American Journal of Hypertension, 34, pp. 92-99. (doi: 10.1093/ajh/hpaa166)

Willder, J. M., McCall, P., Messow, C.-M., Gillies, M., Berry, C., Shelley, B. (2021) Study protocol for COVID-RV: a multicentre prospective observational cohort study of right ventricular dysfunction in ventilated patients with COVID-19. BMJ Open, 11, (doi: 10.1136/bmjopen-2020-042098)

Jacobs, M., Benovoy, M., Chang, L.-C., Corcoran, D., Berry, C., Arai, A. E., Hsu, L.-Y. (2021) Automated segmental analysis of fully quantitative myocardial blood flow maps by first-pass perfusion cardiovascular magnetic resonance. IEEE Access, 9, pp. 52796-52811. (doi: 10.1109/ACCESS.2021.3070320)

Kamdar, A., Sykes, R., Morrow, A., Mangion, K., Berry, C. (2021) Cardiovascular outcomes of glucose lowering therapy in chronic kidney disease patients: a systematic review with meta-analysis. Reviews in Cardiovascular Medicine, 22, pp. 1479-1490. (doi: 10.31083/j.rcm2204152)

Small, H. Y., Delles, C. (2021) Letter to the Editor regarding Cunningham et al. 2020. Hypertension in Pregnancy, 40, pp. 133. (doi: 10.1080/10641955.2021.1899201)

McGettrick, M., MacLellan, A., McCaughey, P., Bagot, C., Brewis, M.J., Lang, N.N., Johnson, M.K., Church, A.C. (2021) Pulmonary thromboembolism in hospitalised patients with COVID-19: a retrospective national study of patients managed in critical care and ward environments in Scotland. BMJ Open, 11, (doi: 10.1136/bmjopen-2021-050281)

Sykes, R., Briscoe, M., Krystofiak, T., Peck, O., Mangion, K., Berry, C. (2021) Type 2 myocardial infarction and myocardial injury: eligibility for novel medical therapy to de-risk clinical trials. Open Heart, 8, (doi: 10.1136/openhrt-2021-001633)

Ang, D. T. Y., Berry, C. (2021) What an interventionalist needs to know about INOCA. Interventional Cardiology Review, 16, (doi: 10.15420/icr.2021.16)

Sykes, R., Doherty, D., Mangion, K., Morrow, A., Berry, C. (2021) What an interventionalist needs to know about MI with non-obstructive coronary arteries. Interventional Cardiology Review, 16, (doi: 10.15420/icr.2021.10)

2020

Rossitto, G., Mary, S., McAllister, C., Neves, K. B., Haddow, L., Rocchiccioli, J. P., Lang, N. N., Murphy, C. L., Touyz, R. M., Petrie, M. C., Delles, C. (2020) Reduced lymphatic reserve in heart failure with preserved ejection fraction. Journal of the American College of Cardiology, 76, pp. 2817-2829. (doi: 10.1016/j.jacc.2020.10.022)

Mangion, K. et al. (2020) The Chief Scientist Office cardiovascular and pulmonary imaging in SARS Coronavirus disease-19 (CISCO-19) study. Cardiovascular Research, 116, pp. 2185-2196. (doi: 10.1093/cvr/cvaa209)

Surendran, P. et al. (2020) Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nature Genetics, 52, pp. 1314-1332. (doi: 10.1038/s41588-020-00713-x)

Mangion, K., Loughrey, C., Auger, D. A., McComb, C., Lee, M. M., Corcoran, D., McEntegart, M., Davie, A., Good, R., Lindsay, M., Eteiba, H., Rocchiccioli, J. P., Watkins, S., Hood, S., Shaukat, A., Haig, C., Epstein, F. H., Berry, C. (2020) Displacement encoding with stimulated echoes enables the identification of infarct transmurality early postmyocardial infarction. Journal of Magnetic Resonance Imaging, 52, pp. 1722-1731. (doi: 10.1002/jmri.27295)

Zamai, N., Cortie, C. H., Jarvie, E. M., Onyiaodike, C. C., Alrehaili, A., Francois, M., Freeman, D. J., Meyer, B. J. (2020) In pregnancy, maternal HDL is specifically enriched in, and carries the highest proportion of, DHA in plasma. Prostaglandins, Leukotrienes and Essential Fatty Acids, 163, (doi: 10.1016/j.plefa.2020.102209)

Main, A., Fuller, W., Baillie, G. S. (2020) Post-translational regulation of cardiac myosin binding protein-C: a graphical review. Cellular Signalling, 76, (doi: 10.1016/j.cellsig.2020.109788)

O'Toole, D., Zaeri, A. A. I., Nicklin, S. A., French, A. T., Loughrey, C. M., Martin, T. P. (2020) Signalling pathways linking cysteine cathepsins to adverse cardiac remodelling. Cellular Signalling, 76, (doi: 10.1016/j.cellsig.2020.109770)

McFall, A., Nicklin, S. A., Work, L. M. (2020) The counter regulatory axis of the renin angiotensin system in the brain and ischaemic stroke: insight from preclinical stroke studies and therapeutic potential. Cellular Signalling, 76, (doi: 10.1016/j.cellsig.2020.109809)

Pashova, A., Work, L.M., Nicklin, S.A. (2020) The role of extracellular vesicles in neointima formation post vascular injury. Cellular Signalling, 76, (doi: 10.1016/j.cellsig.2020.109783)

Beazer, J. D., Patanapirunhakit, P., Gill, J. M.R., Graham, D., Karlsson, H., Ljunggren, S., Mulder, M., Freeman, D. J. (2020) High-density lipoprotein’s vascular protective functions in metabolic and cardiovascular disease - could extracellular vesicles be at play? Clinical Science, 134, pp. 2977-2986. (doi: 10.1042/CS20200892)

Ho, F. K., Celis-Morales, C. A., Gray, S. R., Katikireddi, S. V., Niedzwiedz, C. L., Hastie, C., Ferguson, L. D., Berry, C., Mackay, D. F., Gill, J. M.R., Pell, J. P., Sattar, N., Welsh, P. (2020) Modifiable and non-modifiable risk factors for COVID-19, and comparison to risk factors for influenza and pneumonia: results from a UK Biobank prospective cohort study. BMJ Open, 10, (doi: 10.1136/bmjopen-2020-040402)

Briscoe, M., Sykes, R. A., Krysztofiak, T., Peck, O. H., Mangion, K., Berry, C. (2020) Clinical Significance of Coronavirus Disease 2019 in Hospitalized Patients With Myocardial Injury. (doi: 10.1161/circ.142.suppl_3.15932)

Briscoe, M., Sykes, R. A., Krysztofiak, T., Mangion, K., Peck, O. H., Berry, C. (2020) Clinical Significance of Troponin Elevation in a Contemporary Hospitalized Population: Endotypes, Morbidity and In-hospital Mortality. (doi: 10.1161/circ.142.suppl_3.14870)

Charla, E., Mercer, J., Maffia, P., Nicklin, S. (2020) Extracellular vesicle signalling in atherosclerosis. Cellular Signalling, 75, (doi: 10.1016/j.cellsig.2020.109751)

McCartney, P. J. et al. (2020) Low-dose intracoronary alteplase during primary percutaneous coronary intervention in patients with acute myocardial infarction: the T-TIME three-arm RCT. Efficacy and Mechanism Evaluation, 7, (doi: 10.3310/eme07050)

Morrow, A. J. et al. (2020) Rationale and design of the Medical Research Council precision medicine with Zibotentan in microvascular angina (PRIZE) trial. American Heart Journal, 229, pp. 70-80. (doi: 10.1016/j.ahj.2020.07.007)

Crawford, F., Chappell, F. M., Lewsey, J., Riley, R., Hawkins, N., Nicolson, D., Heggie, R., Smith, M., Horne, M., Amanna, A., Martin, A., Gupta, S., Gray, K., Weller, D., Brittenden, J., Leese, G. (2020) Risk assessments and structured care interventions for prevention of foot ulceration in diabetes: development and validation of a prognostic model. Health Technology Assessment, 24, (doi: 10.3310/hta24620)

Langhorne, P., Audebert, H. J., Cadilhac, D. A., Kim, J., Lindsay, P. (2020) Stroke systems of care in high-income countries: what is optimal? Lancet, 396, pp. 1433-1442. (doi: 10.1016/S0140-6736(20)31363-5)

Kunadian, V., Chieffo, A., Camici, P. G., Berry, C., Escaned, J., Maas, A. H. E. M., Prescott, E., Karam, N., Appelman, Y., Fraccaro, C., Louise Buchanan, G., Manzo-Silberman, S., Al-Lamee, R., Regar, E., Lansky, A., Abbott, J. D., Badimon, L., Duncker, D. J., Mehran, R., Capodanno, D., Baumbach, A. (2020) An EAPCI expert consensus document on ischaemia with non-obstructive coronary arteries in collaboration with European Society of Cardiology Working Group on Coronary Pathophysiology & Microcirculation endorsed by Coronary Vasomotor Disorders International Study Group. European Heart Journal, 41, pp. 3504-3520. (doi: 10.1093/eurheartj/ehaa503)

Lang, N. N., Dobbin, S. J.H., Petrie, M. C. (2020) Vericiguat in worsening heart failure – agonising over, or celebrating, agonism. Cardiovascular Research, 116, pp. e152-e155. (doi: 10.1093/cvr/cvaa247)

Dowsett, L., Higgins, E., Alanazi, S., Alshuwayer, N. A., Leiper, F. C., Leiper, J. (2020) ADMA: A key player in the relationship between vascular dysfunction and inflammation in atherosclerosis. Journal of Clinical Medicine, 9, (doi: 10.3390/jcm9093026)

Ford, T. J., Corcoran, D., Padmanabhan, S., Aman, A., Rocchiccioli, P., Good, R., McEntegart, M., Maguire, J. J., Watkins, S., Eteiba, H., Shaukat, A., Lindsay, M., Robertson, K., Hood, S., McGeoch, R., McDade, R., Yii, E., Sattar, N., Hsu, L.-Y., Arai, A. E., Oldroyd, K. G., Touyz, R. M., Davenport, A. P., Berry, C. (2020) Genetic dysregulation of endothelin-1 is implicated in coronary microvascular dysfunction. European Heart Journal, 41, pp. 3239-3252. (doi: 10.1093/eurheartj/ehz915)

Sattar, N., Ho, F. K., Gill, J. M.R., Ghouri, N., Gray, S. R., Celis-Morales, C. A., Katikireddi, S. V., Berry, C., Pell, J. P., McMurray, J. J.V., Welsh, P. (2020) BMI and future risk for COVID-19 infection and death across sex, age and ethnicity: preliminary findings from UK biobank. Diabetes and Metabolic Syndrome: Clinical Research and Reviews, 14, pp. 1149-1151. (doi: 10.1016/j.dsx.2020.06.060)

Cameron, A. C., McMahon, K., Hall, M., Neves, K. B., Rios, F. J., Montezano, A. C., Welsh, P., Waterston, A., White, J., Mark, P. B., Touyz, R. M., Lang, N. N. (2020) Comprehensive characterisation of the vascular effects of cisplatin-based chemotherapy in patients with testicular cancer. JACC: CardioOncology, 2, pp. 443-455. (doi: 10.1016/j.jaccao.2020.06.004)

Ford, T. J., Ong, P., Sechtem, U., Beltrame, J., Camici, P. G., Crea, F., Kaski, J.-C., Bairey Merz, C. N., Pepine, C. J., Shimokawa, H., Berry, C. (2020) Assessment of vascular dysfunction in patients without obstructive coronary artery disease: why, how and when. JACC: Cardiovascular Interventions, 13, pp. 1847-1864. (doi: 10.1016/j.jcin.2020.05.052)

Rossitto, G., Mary, S., Chen, J. Y., Bodder, P., Chew, K. S., Neves, K. B., Alves, R. L., Montezano, A. C., Welsh, P., Petrie, M. C., Graham, D., Touyz, R. M., Delles, C. (2020) Tissue sodium excess is not hypertonic and reflects extracellular volume expansion. Nature Communications, 11, (doi: 10.1038/s41467-020-17820-2)

McClure, J. D., Ramsay, J. C., Berry, C. (2020) Pooled analysis of bleeding and major adverse cardiovascular events in clinical trials of time-constrained dual-antiplatelet therapy after percutaneous coronary intervention. Journal of the American Heart Association, 9, (doi: 10.1161/JAHA.120.017109)

Guzik, T. J., Mohiddin, S. A., Dimarco, A., Patel, V., Savvatis, K., Marelli-Berg, F. M., Madhur, M. S., Tomaszewksi, M., Maffia, P., D'Acquisto, F., Nicklin, S. A., Marian, A. J., Nosalski, R., Murray, E. C., Guzik, B., Berry, C., Touyz, R. M., Kreutz, R., Wang, D. W., Bhella, D., Sagliocco, O., Crea, F., Thomson, E. C., McInnes, I. B. (2020) COVID-19 and the cardiovascular system: implications for risk assessment, diagnosis, and treatment options. Cardiovascular Research, 116, pp. 1666-1687. (doi: 10.1093/cvr/cvaa106)

Fisher, R. J., Byrne, A., Chouliara, N., Lewis, S., Paley, L., Hoffman, A., Rudd, A., Robinson, T., Langhorne, P., Walker, M. F. (2020) Effectiveness of stroke early supported discharge. Circulation: Cardiovascular Quality and Outcomes, 13, (doi: 10.1161/circoutcomes.119.006395)

Zou, Z.-G., Rios, F. J., Neves, K. B., Alves-Lopes, R., Ling, J., Baillie, G. S., Gao, X., Fuller, W., Camargo, L. L., Gudermann, T., Chubanov, V., Montezano, A. C., Touyz, R. M. (2020) Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function. Clinical Science, 134, pp. 2019-2035. (doi: 10.1042/CS20200827)

Connelly, P. J., Jandeleit-Dahm, K. A.M., Delles, C. (2020) Sex and gender aspects in vascular pathophysiology. Clinical Science, 134, pp. 2203-2207. (doi: 10.1042/CS20200876)

Campbell, R. T., Jasilek, A., Mischak, H., Nkuipou-Kenfack, E., Latosinska, A., Welsh, P. I., Jackson, C. E., Cannon, J., McConnachie, A., Delles, C., McMurray, J. J.V. (2020) The novel urinary proteomic classifier HF1 has similar diagnostic and prognostic utility to BNP in heart failure. ESC Heart Failure, 7, pp. 1595-1604. (doi: 10.1002/ehf2.12708)

Demin, A., Løge, B., Zhiteneva, O., Nishida, C., Whiting, S., Rippin, H., Delles, C., Karymbaeva, S., Wickramasinghe, K., Breda, J. (2020) Trans fatty acid elimination policy in member states of the Eurasian Economic Union: implementation challenges and capacity for enforcement. Journal of Clinical Hypertension, 22, pp. 1328-1337. (doi: 10.1111/jch.13945)

Tarar, O. M., Ahmed, K. M., Nishtar, N. A., Achakzai, A. B. K., Gulzar, Y., Delles, C., Al-Jawaldeh, A. (2020) Understanding the complexities of prevalence of trans fat and its control in food supply in Pakistan. Journal of Clinical Hypertension, 22, pp. 1338-1346. (doi: 10.1111/jch.13943)

Dobbie, L. J., Mackin, S. T., Hogarth, K., Lonergan, F., Kannenkeril, D., Brooksbank, K., Delles, C. (2020) Validation of semi-automated flow mediated dilation measurement in healthy volunteers. Blood Pressure Monitoring, 25, pp. 216-223. (doi: 10.1097/MBP.0000000000000448)

MacDonald, E. A., Madl, J., Greiner, J., Ramadan, A. F., Wells, S. M., Torrente, A. G., Kohl, P., Rog-Zielinska, E. A., Quinn, T. A. (2020) Sinoatrial node structure, mechanics, electrophysiology and the chronotropic response to stretch in rabbit and mouse. Frontiers in Physiology, 11, (doi: 10.3389/fphys.2020.00809)

Fong, L. C. W., Ford, T. J., da Costa, B. R., Jüni, P., Berry, C. (2020) Bias and loss to follow-up in cardiovascular randomized trials: a systematic review. Journal of the American Heart Association, 9, (doi: 10.1161/JAHA.119.015361)

Bulluck, H., Carberry, J., Carrick, D., McEntegart, M., Petrie, M. C., Eteiba, H., Hood, S., Watkins, S., Lindsay, M., Mahrous, A., Ford, I., Oldroyd, K. G., Berry, C. (2020) Redefining adverse and reverse left ventricular remodeling by cardiovascular magnetic resonance following ST-segment elevation myocardial infarction and their implications on long-term prognosis. Circulation: Cardiovascular Imaging, 13, (doi: 10.1161/CIRCIMAGING.119.009937)

Louca, P., Mompeo, O., Leeming, E. R., Berry, S. E., Mangino, M., Spector, T. D., Padmanabhan, S., Menni, C. (2020) Dietary influence on systolic and diastolic blood pressure in the TwinsUK cohort. Nutrients, 12, (doi: 10.3390/nu12072130)

Drozdowska, B. A., Elliott, E., Taylor-Rowan, M., Shaw, R. C., Cuthbertson, G., Langhorne, P., Quinn, T. J. (2020) Cardiovascular risk factors indirectly affect acute post-stroke cognition through stroke severity and prior cognitive impairment: A moderated mediation analysis. Alzheimer's Research and Therapy, 12, (doi: 10.1186/s13195-020-00653-y)

Lees, J. S., Mangion, K., Rutherford, E., Witham, M. D., Woodward, R., Roditi, G., Hopkins, T., Brooksbank, K., Jardine, A., Mark, P. B. (2020) Vitamin K for kidney transplant organ recipients: investigating vEssel stiffness (ViKTORIES): study rationale and protocol of a randomised controlled trial. Open Heart, 7, (doi: 10.1136/openhrt-2019-001070)

Dobbin, S. J.H., Mangion, K., Berry, C., Roditi, G., Basak, S., Sourbron, S., White, J., Venugopal, B., Touyz, R. M., Jones, R. J., Petrie, M. C., Lang, N. N. (2020) Cardiotoxicity and myocardial hypoperfusion associated with anti-VEGF therapies: prospective cardiac magnetic resonance imaging in patients with cancer. European Journal of Heart Failure, 22, pp. 1276-1277. (doi: 10.1002/ejhf.1847)

Currie, G., Mary, S., Delles, C. (2020) Is there a role for proteomics in diabetic renal disease? NDT Plus, 35, pp. 1133-1135. (doi: 10.1093/ndt/gfz017)

Riddell, A., McBride, M., Braun, T., Nicklin, S. A., Cameron, E., Loughrey, C. M., Martin, T. P. (2020) RUNX1: an emerging therapeutic target for cardiovascular disease. Cardiovascular Research, 116, pp. 1410-1423. (doi: 10.1093/cvr/cvaa034)

Williams, J. J.L., Baillie, G. S., Palmer, T. M. (2020) Investigation of Novel Cavin-1/Suppressor of Cytokine Signaling 3 (SOCS3) Interactions by Coimmunoprecipitation, Peptide Pull-Down, and Peptide Array Overlay Approaches. Springer

Al-Hussaini, A., Abdelaty, A. M.S.E.K., Gulsin, G. S., Arnold, J. R., Garcia-Guimaraes, M., Premawardhana, D., Budgeon, C., Wood, A., Natarajan, N., Mangion, K., Rakhit, R., Hoole, S. P., Johnson, T. W., Berry, C., Hudson, I., Gershlick, A. H., Ladwiniec, A., Kovac, J., Squire, I., Samani, N. J., Plein, S., McCann, G. P., Adlam, D. (2020) Chronic infarct size after spontaneous coronary artery dissection: implications for pathophysiology and clinical management. European Heart Journal, 41, pp. 2197-2205. (doi: 10.1093/eurheartj/ehz895)

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Cameron, A. C., Rossitto, G., Lang, N. N., Touyz, R. M. (2019) Antihypertensive drugs and vascular health. Springer

Ravassa, S., Delles, C., Currie, G., Díez, J. (2019) Biomarkers of cardiovascular disease. Springer

Purnama Sidik, N., McCartney, P., Berry, C. (2019) Coronary microvascular disease. Springer

Small, H. Y., Currie, G., Delles, C. (2019) Endothelial dysfunction. Springer

Brittenden, J., Cooper, D., Dimitrova, M., Scotland, G., Cotton, S., Elders, A., MacLennan, G., Ramsay, C. R., Norrie, J., Burr, J. M., Campbell, B., Bachoo, P., Chetter, I., Gough, M., Earnshaw, J., Lees, T., Scott, J., Baker, S. A., Tassie, E., Francis, J., Campbell, M. K. (2019) Five-Year outcomes of a randomized trial of treatments for varicose veins. New England Journal of Medicine, 381, pp. 912-922. (doi: 10.1056/nejmoa1805186)

Padmanabhan, S., Aman, A., Dominiczak, A. F. (2019) Genetics of hypertension and heart failure. Springer International Publishing

Padmanabhan, S., Aman, A., Dominiczak, A. F. (2019) Genomics of hypertension. Springer

Tibbo, A. J., Busiau, T., Baillie, G. S. (2019) Methods to investigate arrestins in complex with phosphodiesterases. Springer

Logue, J., Sattar, N., Freeman, D. (2019) Obesity. Springer

MacKenzie, S. M., Van Kralingen, J. C., Davies, E. (2019) Regulation of aldosterone secretion. Elsevier

Corcoran, D., Ford, T. J., Berry, C. (2019) Stable coronary syndromes. Springer

Blair, C. M., Walsh, N., Littman, B. H., Marcoux, F. W., Baillie, G. S. (2019) Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A – C-Raf. BMC Cancer, 19, (doi: 10.1186/s12885-019-5489-4)

(2019) Textbook of Vascular Medicine. (doi: 10.1007/978-3-030-16481-2)

Cameron, A. C., Touyz, R. M., Lang, N. N. (2019) Vascular biology of cancer chemotherapeutic drugs. Springer

Graham, D. (2019) Vascular physiology. Springer

Nather, K., Loughrey, C. M., Nicklin, S. A. (2019) Vasoactive peptides: renin-angiotensin-aldosterone system. Springer

2018

Arnau-Soler, A., Adams, M. J., Generation Scotland, , Major Depressive Disorder Working Group, P. G. C., Hayward, C., Thomson, P. A. (2018) Genome-wide interaction study of a proxy for stress-sensitivity and its prediction of major depressive disorder. PLoS ONE, 13, (doi: 10.1371/journal.pone.0209160)

Ford, T. J., Stanley, B., Good, R., Rocchiccioli, P., McEntegart, M., Watkins, S., Eteiba, H., Shaukat, A., Lindsay, M., Robertson, K., Hood, S., McGeoch, R., McDade, R., Yii, E., Sidik, N., McCartney, P., Corcoran, D., Collison, D., Rush, C., McConnachie, A., Touyz, R., Oldroyd, K., Berry, C. (2018) Stratified medical therapy using invasive coronary function testing in angina: CorMicA trial. Journal of the American College of Cardiology, 72, pp. 2841-2855. (doi: 10.1016/j.jacc.2018.09.006)

Ford, T. J., Rocchiccioli, P., Good, R., McEntegart, M., Eteiba, H., Watkins, S., Shaukat, A., Lindsay, M., Robertson, K., Hood, S., Yii, E., Sidik, N., Harvey, A., Montezano, A. C., Beattie, E., Haddow, L., Oldroyd, K. G., Touyz, R. M., Berry, C. (2018) Systemic microvascular dysfunction in microvascular and vasospastic angina. European Heart Journal, 39, pp. 4086-4097. (doi: 10.1093/eurheartj/ehy529)

Strembitska, A., Mancini, S. J., Gamwell, J. M., Palmer, T. M., Baillie, G. S., Salt, I. P. (2018) A769662 inhibits insulin-stimulated Akt activation in human macrovascular endothelial cells independent of AMP-activated protein kinase. International Journal of Molecular Sciences, 19, (doi: 10.3390/ijms19123886)

Pulit, S. L., Weng, L.-C., McArdle, P. F., Trinquart, L., Choi, S. H., Mitchell, B. D., Rosand, J., de Bakker, P. I. W., Benjamin, E. J., Ellinor, P. T., Kittner, S. J., Lubitz, S. A., Anderson, C. D., Padmanabhan, S., Ford, I., Macfarlane, P. W., Walters, M. (2018) Atrial fibrillation genetic risk differentiates cardioembolic stroke from other stroke subtypes. Neurology Genetics, 4, (doi: 10.1212/NXG.0000000000000293)

Rossitto, G., Touyz, R. M., Petrie, M. C., Delles, C. (2018) Much Ado about N...atrium: modelling tissuesodium as a highly sensitive marker of subclinicaland localized oedema. Clinical Science, 132, pp. 2609-2613. (doi: 10.1042/CS20180575)

Lyons, M., Smith, C., Boaden, E., Brady, M. C., Brocklehurst, P., Dickinson, H., Hamdy, S., Higham, S., Langhorne, P., Lightbody, C., McCracken, G., Medina-Lara, A., Sproson, L., Walls, A., Watkins, D. C. (2018) Oral care after stroke: Where are we now? European Stroke Journal, 3, pp. 347-354. (doi: 10.1177/2396987318775206)

Alghamdi, J., Matou-Nasri, S., Alghamdi, F., Alghamdi, S., Alfadhel, M., Padmanabhan, S. (2018) Risk of neuropsychiatric adverse effects of lipid-lowering drugs: a Mendelian randomization study. International Journal of Neuropsychopharmacology, 21, pp. 1067-1075. (doi: 10.1093/ijnp/pyy060)

Dobbin, S. J.H., Cameron, A. C., Petrie, M. C., Jones, R. J., Touyz, R. M., Lang, N. N. (2018) Toxicity of cancer therapy: what the cardiologist needs to know about angiogenesis inhibitors. Heart, 104, pp. 1995-2002. (doi: 10.1136/heartjnl-2018-313726)

Maziarz, M., Broselid, S., DiGiacomo, V., Park, J.-C., Luebbers, A., Garcia-Navarrete, L., Blanco-Canosa, J. B., Baillie, G. S., Garcia-Marcos, M. (2018) A biochemical and genetic discovery pipeline identifies PLCδ4b as a non-receptor activator of heterotrimeric G proteins. Journal of Biological Chemistry, 293, pp. 16964-16983. (doi: 10.1074/jbc.RA118.003580)

Welsh, P., Preiss, D., Shah, A. S.V., McAllister, D., Briggs, A., Boachie, C., McConnachie, A., Hayward, C., Padmanabhan, S., Welsh, C., Woodward, M., Campbell, A., Porteous, D., Mills, N. L., Sattar, N. (2018) Comparison between high-sensitivity cardiac troponin T and cardiac troponin I in a large general population cohort. Clinical Chemistry, 64, pp. 1607-1616. (doi: 10.1373/clinchem.2018.292086)

MacDonald, E., Quinn, T. A. (2018) Mechanical Determinants of the Chronotropic Response to Sinoatrial Stretch. (doi: 10.1016/j.yjmcc.2018.07.030)

Sliz, E. et al. (2018) Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment. Circulation, 138, pp. 2499-2512. (doi: 10.1161/CIRCULATIONAHA.118.034942)

Graham, L. A., Aman, A., Campbell, D. D., Augley, J., Graham, D., McBride, M. W., Fraser, N. J., Ferreri, N. R., Dominiczak, A. F., Padmanabhan, S. (2018) Salt stress in the renal tubules is linked to TAL specific expression of uromodulin and an upregulation of heat shock genes. Physiological Genomics, 50, pp. 964-972. (doi: 10.1152/physiolgenomics.00057.2018)

Langhorne, P., Collier, J. M., Bate, P. J., Thuy, M. N.T., Bernhardt, J. (2018) Very early versus delayed mobilisation after stroke. Cochrane Database of Systematic Reviews, 10, (doi: 10.1002/14651858.CD006187.pub3)

Guzik, T. J., Antoniades, C., Baker, A. H., Harrison, D. G., Loughrey, C. M., Maffia, P., Murphy, E., Nicklin, S. A., Peter, K., Pearson, J., Casadei, B. (2018) What matters in Cardiovascular Research? Scientific discovery driving clinical delivery. Cardiovascular Research, 114, pp. 1565-1568. (doi: 10.1093/cvr/cvy214)

Mukhtar, O., Cheriyan, J., Cockcroft, J. R., Collier, D., Coulson, J. M., Dasgupta, I., Faconti, L., Glover, M., Heagerty, A. M., Khong, T. K., Lip, G. Y.H., Mander, A. P., Marchong, M. N., Martin, U., McDonnell, B. J., McEniery, C. M., Padmanabhan, S., Saxena, M., Sever, P. J., Shiel, J. I., Wych, J., Chowienczyk, P. J., Wilkinson, I. B. (2018) A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: the comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program-AIM-HY INFORM trial. American Heart Journal, 204, pp. 102-108. (doi: 10.1016/j.ahj.2018.05.006)

Urimubenshi, G., Langhorne, P., O'Donnell, M.J., Chin, S.L., Yusuf, Y., INTERSTROKE Collaborators, T. (2018) Association Between Key Performance Indicators and Patient Outcomes in Low and Middle-Income Countries in the INTERSTROKE Study. (doi: 10.1177/1747493018802481)

Bosch, J., Langhorne, P., O'Donnell, M., Urimubenshi, G., Katsoulis, L., Pandian, J., Kaddumukasa, M., DePaul, V., Carroll, S., Perera, K., Hamilton, L., Bidulka, P. (2018) Can Key Elements of a Stroke Unit be Implemented in Resource Scarce Settings? Where do we Start (the OSCAIL study) (doi: 10.1177/1747493018789543)

Tofte, N. et al. (2018) Characteristics of high- and low-risk individuals in the PRIORITY study: urinary proteomics and mineralocorticoid receptor antagonism for prevention of diabetic nephropathy in Type 2 diabetes. Diabetic Medicine, 35, pp. 1375-1382. (doi: 10.1111/dme.13669)

Katsoulis, L., Bosch, J., Langhorne, P., van Zyl, D., Hiesgen, J., Human, S., Urimubenshi, G., Hamilton, L., Bidulka, P. (2018) Characterization of Strokes Admitted to Kalafong Hospital, Pretoria, South Africa During the Baseline Phase of the OSCAIl Study. (doi: 10.1177/1747493018789543)

Dayan, N., Schlosser, K., Stewart, D. J., Delles, C., Kaur, A., Pilote, L. (2018) Circulating microRNAs implicate multiple atherogenic abnormalities in the long-term cardiovascular sequelae of preeclampsia. American Journal of Hypertension, 31, pp. 1093-1097. (doi: 10.1093/ajh/hpy069)

Katsoulis, L., Urimubenshi, G., Langhorne, P., Bosch, J., van Zyl, D., Hiesgen, J., Human, S., Hamilton, L., Bidulka, P., O'Donnell, M. (2018) Data from the OSCAIL Study on Time from Stroke Onset to Presentation at 3 Public African Hospitals: Two in Rwanda and One in South Africa. (doi: 10.1177/1747493018789543)

Morinello, C., Bewick, M., Koch, N., Bosch, J., Langhorne, P., Urimubenshi, G., Katsoulis, L., DePaul, V., Carroll, S., Hamilton, L. (2018) Developing Rehabilitation Specific Training for Organized Stroke Care in Low and Middle-Income Countries: What is Needed and How to Implement. (doi: 10.1177/1747493018789543)

Evangelou, E. et al. (2018) Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits. Nature Genetics, 50, pp. 1412-1425. (doi: 10.1038/s41588-018-0205-x)

DePaul, V., Urimubenshi, G., Bosch, J., Langhorne, P., Katsoulis, L., O'Donnell, M., Pandian, J., Hamilton, L., Bidulka, P., Carroll, S., Kaddumukasa, M., Perera, K. (2018) Mobility-Related Care After Stroke in the Rwandan and South African Context: Identifying Opportunities for Improvement Through the Organized Stroke Care Across Income Levels (OSCAIL) Study. (doi: 10.1177/1747493018789543)

Rosenthal, E. A., Shirts, B. H., Amendola, L. M., Horike-Pyne, M., Robertson, P. D., Hisama, F. M., Bennett, R. L., Dorschner, M. O., Nickerson, D. A., Stanaway, I. B., Nassir, R., Vickers, K. T., Li, C., Grady, W. M., Peters, U., Jarvik, G. P., NHLBI GO Exome Sequencing Project, (2018) Rare loss of function variants in candidate genes and risk of colorectal cancer. Human Genetics, 137, pp. 795-806. (doi: 10.1007/s00439-018-1938-4)

Berry, C., Mangion, K., Pathan, F. (2018) Spotlight on strain following myocardial infarction. JACC: Cardiovascular Imaging, 11, pp. 1445-1447. (doi: 10.1016/j.jcmg.2018.01.004)

Urimubenshi, G., Cadilhac, D. A., Kagwiza, J. N., Wu, O., Langhorne, P. (2018) Stroke care in Africa: a systematic review of the literature. International Journal of Stroke, 13, pp. 797-805. (doi: 10.1177/1747493018772747)

Hamilton, L., Bosch, J., Bidulka, P., Langhorne, P., DePaul, V., Katsoulis, L., Urimubenshi, G., Dieudonné, D., Munyantore, J., Human, S., Pandian, J., O'Donnell, M. (2018) The Effect of Loss to Follow-up on Estimating Post-Stroke Function and Mortality in Low and Middle-Income Countries: Lessons from the OSCAIL Study. (doi: 10.1177/1747493018789543)

Bidulka, P., Bosch, J., Hamilton, L., DePaul, V., Urimubenshi, G., Katsoulis, L., Langhorne, P., O'Donnell, M., Pandian, J. (2018) The OSCAIL Study: Monitoring Acute Stroke Care Services in Rwanda and South Africa. (doi: 10.1177/1747493018789543)

Elliott, C., Rojo, A. I., Ribe, E., Broadstock, M., Xia, W., Morin, P., Semenov, M., Baillie, G., Cuadrado, A., Al-Shawi, R., Ballard, C. G., Simons, P., Killick, R. (2018) A role for APP in Wnt signalling links synapse loss with β-amyloid production. Translational Psychiatry, 8, (doi: 10.1038/s41398-018-0231-6)

Puntmann, V. O., Valbuena, S., Hinojar, R., Petersen, S. E., Greenwood, J. P., Kramer, C. M., Kwong, R. Y., McCann, G. P., Berry, C., Nagel, E. (2018) Society for Cardiovascular Magnetic Resonance (SCMR) expert consensus for CMR imaging endpoints in clinical research: part I - analytical validation and clinical qualification. Journal of Cardiovascular Magnetic Resonance, 20, (doi: 10.1186/s12968-018-0484-5)

Shah, A. S.V. et al. (2018) High-sensitivity troponin in the evaluation of patients with suspected acute coronary syndrome: a stepped-wedge, cluster-randomised controlled trial. Lancet, 392, pp. 919-928. (doi: 10.1016/S0140-6736(18)31923-8)

The SCOT-HEART Investigators, et al. (2018) Coronary CT angiography and 5-year risk of myocardial infarction. New England Journal of Medicine, 379, pp. 924-933. (doi: 10.1056/NEJMoa1805971)

Corcoran, D., Young, R., Adlam, D., McConnachie, A., Mangion, K., Ripley, D., Cairns, D., Brown, J., Bucciarelli-Ducci, C., Baumbach, A., Kharbanda, R., Oldroyd, K. G., McCann, G. P., Greenwood, J. P., Berry, C. (2018) Coronary microvascular dysfunction in patients with stable coronary artery disease: the CE-MARC 2 coronary physiology sub-study. International Journal of Cardiology, 266, pp. 7-14. (doi: 10.1016/j.ijcard.2018.04.061)

Ravassa, S., Trippel, T., Bach, D., Bachran, D., González, A., López, B., Wachter, R., Hasenfuss, G., Delles, C., Dominiczak, A. F., Pieske, B., Díez, J., Edelmann, F. (2018) Biomarker-based phenotyping of myocardial fibrosis identifies patients with heart failure with preserved ejection fraction resistant to the beneficial effects of spironolactone: results from the Aldo-DHF trial. European Journal of Heart Failure, 20, pp. 1290-1299. (doi: 10.1002/ejhf.1194)

Cumming, T. B., Bernhardt, J., Lowe, D., Collier, J., Dewey, H., Langhorne, P., Thrift, A. G., Green, A., Mohanraj, R., Kramer, S. F., Churilov, L., Linden, T. (2018) Early mobilization after stroke is not associated with cognitive outcome: findings from AVERT. Stroke, 49, pp. 2147-2154. (doi: 10.1161/STROKEAHA.118.022217)

Carrick, D., Haig, C., Maznyczka, A. M., Carberry, J., Mangion, K., Ahmed, N., May, V. T. Y., McEntegart, M., Petrie, M. C., Eteiba, H., Lindsay, M., Hood, S., Watkins, S., Davie, A., Mahrous, A., Mordi, I., Ford, I., Radjenovic, A., Welsh, P., Sattar, N., Wetherall, K., Oldroyd, K. G., Berry, C. (2018) Hypertension, microvascular pathology and prognosis after an acute myocardial infarction. Hypertension, 72, pp. 720-730. (doi: 10.1161/HYPERTENSIONAHA.117.10786)

McEntegart, M. B., Corcoran, D., Carrick, D., Clerfond, G., Sidik, N., Collison, D., Robertson, K. R., Shaukat, A., Watkins, S., Rocchicholi, P. R., Eteiba, H., Petrie, M. P., Lindsay, M. M., Oldroyd, K. G., Berry, C. (2018) Incidence of procedural myocardial infarction and cardiac magnetic resonance imaging-detected myocardial injury following percutaneous coronary intervention with rotational atherectomy. EuroIntervention, 14, pp. 819-823. (doi: 10.4244/EIJ-D-17-01077)

Kim, S. S., Yamamoto, M. H., Maehara, A., Sidik, N., Koyama, K., Berry, C., Oldroyd, K. G., Mintz, G. S., McEntegart, M. (2018) Intravascular ultrasound assessment of the effects of rotational atherectomy in calcified coronary artery lesions. International Journal of Cardiovascular Imaging, 34, pp. 1365-1371. (doi: 10.1007/s10554-018-1352-y)

Engelhardt, B., Holze, J., Elliott, C., Baillie, G.S., Kschischo, M., Fröhlich, H. (2018) Modelling and mathematical analysis of the M2 receptor-dependent joint signalling and secondary messenger network in CHO cells. Mathematical Medicine and Biology, 35, pp. 279-297. (doi: 10.1093/imammb/dqx003)

Roselli, C. et al. (2018) Multi-ethnic genome-wide association study for atrial fibrillation. Nature Genetics, 50, pp. 1225-1233. (doi: 10.1038/s41588-018-0133-9)

Carberry, J., Carrick, D., Haig, C., Ahmed, N., Mordi, I., McEntegart, M., Petrie, M. C., Eteiba, H., Hood, S., Watkins, S., Lindsay, M., Davie, A., Mahrous, A., Ford, I., Sattar, N., Welsh, P., Radjenovic, A., Oldroyd, K. G., Berry, C. (2018) Persistent iron within the infarct core after ST-segment elevation myocardial infarction: implications for left ventricular remodeling and health outcomes. JACC: Cardiovascular Imaging, 11, pp. 1248-1256. (doi: 10.1016/j.jcmg.2017.08.027)

Kobayashi, Y., Lønborg, J., Jong, A., Nishi, T., De Bruyne, B., Høfsten, D. E., Kelbæk, H., Layland, J., Nam, C.-W., Pijls, N. H.J., Tonino, P. A.L., Warnøe, J., Oldroyd, K. G., Berry, C., Engstrøm, T., Fearon, W. F. (2018) Prognostic value of the residual SYNTAX score after functionally complete revascularization in ACS. Journal of the American College of Cardiology, 72, pp. 1321-1329. (doi: 10.1016/j.jacc.2018.06.069)

Divorty, N., Milligan, G., Graham, D., Nicklin, S. A. (2018) The orphan receptor GPR35 contributes to angiotensin II–induced hypertension and cardiac dysfunction in mice. American Journal of Hypertension, 31, pp. 1049-1058. (doi: 10.1093/ajh/hpy073)

Svanerud, J., Ahn, J.-M., Jeremias, A., van 't Veer, M., Gore, A., Maehara, A., Crowley, A., Pijls, N. H.J., De Bruyne, B., Johnson, N. P., Hennigan, B., Watkins, S., Berry, C., Oldroyd, K. G., Park, S.-J., Ali, Z. A. (2018) Validation of a novel non-hyperaemic index of coronary artery stenosis severity: the Resting Full-cycle Ratio (VALIDATE RFR) study. EuroIntervention, 14, pp. 806-814. (doi: 10.4244/EIJ-D-18-00342)

Ford, T. J., McEntegart, M., Berry, C., Oldroyd, K. G. (2018) Arterial access for invasive coronary angiography: the 'left backhander' Heart, Lung and Circulation, 27, pp. e98-e99. (doi: 10.1016/j.hlc.2018.02.021)

Gillis, K., Stevens, K. K., Bell, E., Patel, R. K., Jardine, A. G., Morris, S. T.W., Schneider, M. P., Delles, C., Mark, P. B. (2018) Ascorbic acid lowers central blood pressure and asymmetric dimethylarginine in chronic kidney disease. Clinical Kidney Journal, 11, pp. 532-539. (doi: 10.1093/ckj/sfx158)

Yew, S. N., Carrick, D., Corcoran, D., Ahmed, N., Carberry, J., May, V. T. Y., McEntegart, M., Petrie, M. C., Eteiba, H., Lindsay, M., Hood, S., Watkins, S., Davie, A., Mahrous, A., Mordi, I., Ford, I., Oldroyd, K. G., Berry, C. (2018) Coronary thermodilution waveforms after acute reperfused ST‐segment–elevation myocardial infarction: relation to microvascular obstruction and prognosis. Journal of the American Heart Association, 7, (doi: 10.1161/JAHA.118.008957)

Jones, K. M. et al. (2018) Determining the feasibility and preliminary efficacy of a stroke instructional and educational DVD in a multinational context: a randomized controlled pilot study. Clinical Rehabilitation, 32, pp. 1086-1097. (doi: 10.1177/0269215518777565)

Daly, J. P., Whiteley, E., Freeley, M., Long, A., Malacrida, B., Kiely, P., Baillie, G. S. (2018) RAB40C regulates RACK1 stability via the ubiquitin-proteasome system. Future Science OA, 4, (doi: 10.4155/fsoa-2018-0022)

Shah, S. V., Zimmermann, F. M., Johnson, N. P., Nishi, T., Kobayashi, Y., Witt, N., Berry, C., Jeremias, A., Koo, B.-K., Esposito, G., Rioufol, G., Park, S.-J., Oldroyd, K. G., Barbato, E., Pijls, N. H.J., De Bruyne, B., Fearon, W. F. (2018) Sex differences in adenosine-free coronary pressure indexes: a CONTRAST substudy. JACC: Cardiovascular Interventions, 11, pp. 1454-1463. (doi: 10.1016/j.jcin.2018.03.030)

Ford, T. J., Corcoran, D., Sidik, N., McEntegart, M., Berry, C. (2018) Coronary microvascular dysfunction: Assessment of both structure and function. Journal of the American College of Cardiology, 72, pp. 584-586. (doi: 10.1016/j.jacc.2018.03.545)

Abaraogu, U., Ezenwankwo, E., Dall, P., Tew, G., Stuart, W., Brittenden, J., Seenan, C. (2018) Barriers and enablers to walking in individuals with intermittent claudication: a systematic review to conceptualize a relevant and patient-centered program. PLoS ONE, 13, (doi: 10.1371/journal.pone.0201095)

van Strijp, D., de Witz, C., Vos, P. C., den Biezen, E., van Brussel, A., Wrobel, J., Baillie, G. S., Tennstedt, P., Schlomm, T., Heitkötter, B., Huss, S., Bögemann, M., Houslay, M. D., Bangma, C. H., Semjonow, A., Hoffmann, R. (2018) The prognostic PDE4D7 score in a diagnostic biopsy prostate cancer patient cohort with longitudinal biological outcomes. Prostate Cancer, 2018, (doi: 10.1155/2018/5821616)

Van Setten, J. et al. (2018) PR interval genome-wide association meta-analysis identifies 50 loci associated with atrial and atrioventricular electrical activity. Nature Communications, 9, (doi: 10.1038/s41467-018-04766-9)

Prins, B. P. et al. (2018) Exome-chip meta-analysis identifies novel loci associated with cardiac conduction, including ADAMTS6. Genome Biology, 19, (doi: 10.1186/s13059-018-1457-6)

Rajani, R. M., Quick, S., Ruigrok, S. R., Graham, D., Harris, S. E., Verhaaren, B. F.J., Fornage, M., Seshadri, S., Atanur, S. S., Dominiczak, A. F., Smith, C., Wardlaw, J. M., Williams, A. (2018) Reversal of endothelial dysfunction reduces white matter vulnerability in cerebral small vessel disease in rats. Science Translational Medicine, 10, (doi: 10.1126/scitranslmed.aam9507)

Findlay, I., Morris, T., Zhang, R., Mccowan, C., Shield, S., Forbes, B., McConnachie, A., Mangion, K., Berry, C. (2018) Linking hospital patient records for suspected or established acute coronary syndrome in a complex secondary care system: a proof-of-concept e-registry in NHS Scotland. European Heart Journal: Quality of Care and Clinical Outcomes, 4, pp. 155-167. (doi: 10.1093/ehjqcco/qcy007)

Kishore, A. K., Vail, A., Jeans, A. R., Chamorro, A., Di Napoli, M., Kalra, L., Langhorne, P., Roffe, C., Westendorp, W., Nederkoorn, P. J., Garau, J., van de Beek, D., Montaner, J., Woodhead, M., Meisel, A., Smith, C. J. (2018) Microbiological etiologies of pneumonia complicating stroke: a systematic review. Stroke, 49, pp. 1602-1609. (doi: 10.1161/STROKEAHA.117.020250)

Morgan, H. L., Butler, E., Ritchie, S., Herse, F., Dechend, R., Beattie, E., McBride, M. W., Graham, D. (2018) Modeling superimposed preeclampsia using Ang II (Angiotensin II) infusion in pregnant stroke-prone spontaneously hypertensive rats. Hypertension, 72, pp. 208-218. (doi: 10.1161/HYPERTENSIONAHA.118.10935)

Ford, T. J., Corcoran, D., Oldroyd, K. G., McEntegart, M., Rocchiccioli, P., Watkins, S., Brooksbank, K., Padmanabhan, S., Sattar, N., Briggs, A., McConnachie, A., Touyz, R., Berry, C. (2018) Rationale and design of the British Heart Foundation (BHF) Coronary Microvascular Angina (CorMicA) stratified medicine clinical trial. American Heart Journal, 201, pp. 86-94. (doi: 10.1016/j.ahj.2018.03.010)

De Lucca Camargo, L., Harvey, A. P., Rios, F. J., Tsiropoulou, S., Silva, R. D. N. d. O., Cao, Z., Graham, D., McMaster, C., Burchmore, R. J., Hartley, R. C., Bulleid, N., Montezano, A. C., Touyz, R. M. (2018) Vascular Nox (NADPH oxidase) compartmentalization, protein hyperoxidation, and endoplasmic reticulum stress response in hypertension. Hypertension, 72, pp. 235-246. (doi: 10.1161/HYPERTENSIONAHA.118.10824)

Bailey, E., McBride, M. W., McClure, J. D., Beattie, W., Graham, D., Dominiczak, A., Smith, C., Wardlaw, J. (2018) Effects of dietary salt on gene and protein expression in brain tissue of a model of sporadic small vessel disease. Clinical Science, 132, pp. 1315-1328. (doi: 10.1042/CS20171572)

Montezano, A. C., De Lucca Camargo, L., Persson, P., Rios, F. J., Harvey, A. P., Agnostopoulou, A., Palacios, R., Gandara, A. C. P., Alves-Lopes, R., Neves, K. B., Dulak-Lis, M., Holterman, C. E., Lagerblad de Oliveira, P., Graham, D., Kennedy, C., Touyz, R. M. (2018) NADPH oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7, (doi: 10.1161/JAHA.118.009388)

Feitosa, M. F. et al. (2018) Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries. PLoS ONE, 13, (doi: 10.1371/journal.pone.0198166)

Ford, T. J., McCartney, P., Corcoran, D., Collison, D., Hennigan, B., McEntegart, M., Hildick-Smith, D., Oldroyd, K. G., Berry, C. (2018) Single versus two-stent strategies for coronary bifurcation lesions: a systematic review and meta-analysis of randomized trials with long-term follow-up. Journal of the American Heart Association, 7, (doi: 10.1161/JAHA.118.008730)

Williams, B., MacDonald, T. M., Morant, S. V., Webb, D. J., Sever, P., McInnes, G. T., Ford, I., Cruickshank, J. K., Caulfield, M. J., Padmanabhan, S., Mackenzie, I. S., Salsbury, J., Brown, M. J. (2018) Endocrine and haemodynamic changes in resistant hypertension, and blood pressure responses to spironolactone or amiloride: the PATHWAY-2 mechanisms substudies. Lancet Diabetes and Endocrinology, 6, pp. 464-475. (doi: 10.1016/S2213-8587(18)30071-8)

Montezano, A. C., De Lucca Camargo, L., Persson, P., Rios, F., Harvey, A., Anagnostopoulou, A., Palacios, R., Gandara, A. C. P., Alves‐Lopes, R., Neves, K., Dulak‐Lis, M., Holterman, C. E., de Oliveira, P. L., Graham, D., Kennedy, C., Touyz, R. (2018) NADPH Oxidase 5 is a pro‐contractile Nox isoform and a point of cross‐talk for calcium and redox signaling‐implications in vascular function. Journal of the American Heart Association, 7, (doi: 10.1161/JAHA.118.009388)

Corcoran, D., Ford, T. J., Hsu, L.-Y., Chiribiri, A., Orchard, V., Mangion, K., McEntegart, M., Rocchiccioli, P., Watkins, S., Good, R., Brooksbank, K., Padmanabhan, S., Sattar, N., McConnachie, A., Oldroyd, K. G., Touyz, R. M., Arai, A., Berry, C. (2018) Rationale and design of the Coronary Microvascular Angina Cardiac Magnetic Resonance imaging (CorCMR) diagnostic study: the CorMicA CMR sub-study. Open Heart, 5, (doi: 10.1136/openhrt-2018-000924)

Padmanabhan, S., Aman, A., Dominiczak, A. F. (2018) Recent findings in the genetics of blood pressure: how to apply in practice or is a moonshot required? Current Hypertension Reports, 20, (doi: 10.1007/s11906-018-0863-1)

Moreton, F. C., Cullen, B., Delles, C., Santosh, C., Lopez Gonzalez, R., Dani, K., Muir, K. W. (2018) Vasoreactivity in CADASIL: comparison to structural MRI and neuropsychology. Journal of Cerebral Blood Flow and Metabolism, 38, pp. 1085-1095. (doi: 10.1177/0271678X17710375)

Langhorne, P. et al. (2018) Practice patterns and outcomes after stroke across countries at different economic levels (INTERSTROKE): an international observational study. Lancet, 391, pp. 2019-2027. (doi: 10.1016/S0140-6736(18)30802-X)

Armfield, K., Baillie, G., Wilson, J.B. (2018) Development of Therapeutic Approaches to Targeting Epstein-Barr virus Related Malignancies.

Bulluck, H., Dharmakumar, R., Arai, A. E., Berry, C., Hausenloy, D. J. (2018) Cardiovascular magnetic resonance in acute ST-segment-elevation myocardial infarction: recent advances, controversies, and future directions. Circulation, 137, pp. 1949-1964. (doi: 10.1161/CIRCULATIONAHA.117.030693)

Lin, H. et al. (2018) Common and rare coding genetic variation underlying the electrocardiographic PR interval. Circulation: Genomic and Precision Medicine, 11, (doi: 10.1161/CIRCGEN.117.002037)

de Inda, M. A., van Strijp, D., den Biezen-Timmermans, E., van Brussel, A., Wrobel, J., van Zon, H., Vos, P., Baillie, G. S., Tennstedt, P., Schlomm, T., Houslay, M. D., Bangma, C., Hoffmann, R. (2018) Validation of cyclic adenosine monophosphate phosphodiesterase-4D7 for its independent contribution to risk stratification in a prostate cancer patient cohort with longitudinal biological outcomes. European Urology Focus, 4, pp. 376-384. (doi: 10.1016/j.euf.2017.05.010)

Lygirou, V., Latosinska, A., Makridakis, M., Mullen, W., Delles, C., Schanstra, J. P., Zoidakis, J., Pieske, B., Mischak, H., Vlahou, A. (2018) Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease. Journal of Translational Medicine, 16, (doi: 10.1186/s12967-018-1476-9)

Currie, G. E., von Scholten, B. J., Mary, S., Flores Guerrero, J.-L., Lindhardt, M., Reinhard, H., Jacobsen, P. K., Mullen, W., Parving, H.-H., Mischak, H., Rossing, P., Delles, C. (2018) Urinary proteomics for prediction of mortality in patients with type 2 diabetes and microalbuminuria. Cardiovascular Diabetology, 17, (doi: 10.1186/s12933-018-0697-9)

Delles, C., Currie, G. (2018) Sex differences in hypertension and other cardiovascular diseases. Journal of Hypertension, 36, pp. 768-770. (doi: 10.1097/HJH.0000000000001655)

Mangion, K., Gao, H., Husmeier, D., Luo, X., Berry, C. (2018) Advances in computational modelling for personalised medicine after myocardial infarction. Heart, 104, pp. 550-557. (doi: 10.1136/heartjnl-2017-311449)

Delles, C., Rankin, N. J., Boachie, C., McConnachie, A., Ford, I., Kangas, A., Soininen, P., Trompet, S., Mooijaart, S. P., Jukema, J. W., Zannad, F., Ala-Korpela, M., Salomaa, V., Havulinna, A. S., Welsh, P., Würtz, P., Sattar, N. (2018) Nuclear magnetic resonance-based metabolomics identifies phenylalanine as a novel predictor of incident heart failure hospitalisation: results from PROSPER and FINRISK 1997. European Journal of Heart Failure, 20, pp. 663-673. (doi: 10.1002/ejhf.1076)

Lang, N. N., Walker, N. L. (2018) Adult congenital heart disease and radiation exposure: the malignant price of cardiac care. Circulation, 137, pp. 1346-1348. (doi: 10.1161/CIRCULATIONAHA.117.032815)

Lee, M. M.Y. et al. (2018) Non-Invasive Versus Invasive Management in Patients With Prior Coronary Artery Bypass Surgery With a Non-ST Segment Elevation Acute Coronary Syndrome: Comparisons Between the Randomized Controlled Pilot Trial and Registry. (doi: 10.1016/S0735-1097(18)30586-2)

Weir, C. J., Butcher, I., Assi, V., Lewis, S. C., Murray, G. D., Langhorne, P., Brady, M. C. (2018) Dealing with missing standard deviation and mean values in meta-analysis of continuous outcomes: a systematic review. BMC Medical Research Methodology, 18, (doi: 10.1186/s12874-018-0483-0)

Al-Shahi Salman, R. et al. (2018) The REstart or STop Antithrombotics Randomised Trial (RESTART) after stroke due to intracerebral haemorrhage: study protocol for a randomised controlled trial. Trials, 19, (doi: 10.1186/s13063-018-2542-6)

Bath, P. M. et al. (2018) Antiplatelet therapy with aspirin, clopidogrel, and dipyridamole versus clopidogrel alone or aspirin and dipyridamole in patients with acute cerebral ischaemia (TARDIS): a randomised, open-label, phase 3 superiority trial. Lancet, 391, pp. 850-859. (doi: 10.1016/S0140-6736(17)32849-0)

Sung, Y. J. et al. (2018) A large-scale multi-ancestry genome-wide study accounting for smoking behavior identifies multiple significant loci for blood pressure. American Journal of Human Genetics, 102, pp. 375-400. (doi: 10.1016/j.ajhg.2018.01.015)

Feng, Y.-M., Thijs, L., Zhang, Z.-Y., Yang, W.-Y., Huang, Q.-F., Wei, F.-F., Kuznetsova, T., Jennings, A.-M., Delles, C., Lennox, R., Verhamme, P., Dominiczak, A., Staessen, J. A. (2018) Glomerular function in relation to circulating adhesion molecules and inflammation markers in a general population. Nephrology Dialysis Transplantation, 33, pp. 426-435. (doi: 10.1093/ndt/gfx256)

Sellers, K. J., Elliott, C., Jackson, J., Ghosh, A., Ribe, E., Rojo, A. I., Jarosz-Griffiths, H. H., Watson, I. A., Xia, W., Semenov, M., Morin, P., Hooper, N. M., Porter, R., Preston, J., Al-Shawi, R., Baillie, G., Lovestone, S., Cuadrado, A., Harte, M., Simons, P., Srivastava, D. P., Killick, R. (2018) Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil. Alzheimer's and Dementia, 14, pp. 306-317. (doi: 10.1016/j.jalz.2017.09.008)

Skrobot, O. A. et al. (2018) Progress toward standardized diagnosis of vascular cognitive impairment: guidelines from the Vascular Impairment of Cognition Classification Consensus Study. Alzheimer's and Dementia, 14, pp. 280-292. (doi: 10.1016/j.jalz.2017.09.007)

Chavan-Gautam, P., Rani, A., Freeman, D. J. (2018) Distribution of fatty acids and lipids during pregnancy. Elsevier

Corcoran, D., Young, R., Cialdella, P., McCartney, P., Bajrangee, A., Hennigan, B., Collison, D., Carrick, D., Shaukat, A., Good, R., Watkins, S., McEntegart, M., Watt, J., Welsh, P., Sattar, N., McConnachie, A., Oldroyd, K.G., Berry, C. (2018) The effects of remote ischaemic preconditioning on coronary artery function in patients with stable coronary artery disease. International Journal of Cardiology, 252, pp. 24-30. (doi: 10.1016/j.ijcard.2017.10.082)

Magnus, M. C., Lawlor, D. A., Iliodromiti, S., Padmanabhan, S., Nelson, S. M., Fraser, A. (2018) Age at menarche and cardiometabolic health: a sibling analysis in the Scottish Family Health Study. Journal of the American Heart Association, 7, (doi: 10.1161/JAHA.117.007780)

Currie, G., Delles, C. (2018) Blood pressure targets in the elderly. Journal of Hypertension, 36, pp. 234-236. (doi: 10.1097/HJH.0000000000001576)

Quinn, T. J., Elliott, E., Langhorne, P. (2018) Cognitive and mood assessment tools for use in stroke. Stroke, 49, pp. 483-490. (doi: 10.1161/STROKEAHA.117.016994)

Adamson, P. D., Hunter, A., Williams, M. C., Shah, A. S.V., McAllister, D. A., Pawade, T. A., Dweck, M. R., Mills, N. L., Berry, C., Boon, N. A., Clark, E., Flather, M., Forbes, J., McLean, S., Roditi, G., van Beek, E. J.R., Timmis, A. D., Newby, D. E. (2018) Diagnostic and prognostic benefits of computed tomography coronary angiography using the 2016 National Institute for Health and Care Excellence guidance within a randomised trial. Heart, 104, pp. 207-214. (doi: 10.1136/heartjnl-2017-311508)

Askim, T. et al. (2018) Efficacy and safety of individualized coaching after stroke: the LAST Study (Life After Stroke): a pragmatic randomized controlled trial. Stroke, 49, pp. 426-432. (doi: 10.1161/STROKEAHA.117.018827)

Adamson, P. D., Hunter, A., Madsen, D. M., Shah, A. S.V., McAllister, D. A., Pawade, T. A., Williams, M. C., Berry, C., Boon, N. A., Flather, M., Forbes, J., McLean, S., Roditi, G., Timmis, A. D., van Beek, E. J.R., Dweck, M. R., Mickley, H., Mills, N. L., Newby, D. E. (2018) High-sensitivity cardiac troponin I and the diagnosis of coronary artery disease in patients with suspected angina pectoris. Circulation: Cardiovascular Quality and Outcomes, 11, (doi: 10.1161/CIRCOUTCOMES.117.004227)

Ford, T. J., Corcoran, D., Berry, C. (2018) Stable coronary syndromes: pathophysiology, diagnostic advances and therapeutic need. Heart, 104, pp. 284-292. (doi: 10.1136/heartjnl-2017-311446)

Fertig, B. A., Baillie, G. S. (2018) PDE4-mediated cAMP signalling. Journal of Cardiovascular Development and Disease, 5, (doi: 10.3390/jcdd5010008)

Onyiaodike, C. C., Murray, H. M., Zhang, R., Meyer, B. J., Jordan, F., Brown, E. A., Nibbs, R. J.B., Lyall, H., Sattar, N., Nelson, S. M., Freeman, D. J. (2018) Pre-conception maternal erythrocyte saturated to unsaturated fatty acid ratio predicts pregnancy after natural cycle frozen embryo transfer. Scientific Reports, 8, (doi: 10.1038/s41598-018-19500-0)

Williams, J. J.L., Al-Otaiq, N., Mullen, W., Burchmore, R., Liu, L., Baillie, G. S., Schaper, F., Pilch, P. F., Palmer, T. M. (2018) Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability. Nature Communications, 9, (doi: 10.1038/s41467-017-02585-y)

Gallacher, K. L., May, C. R., Langhorne, P., Mair, F. S. (2018) A conceptual model of treatment burden and patient capacity in stroke. BMC Family Practice, 19, (doi: 10.1186/s12875-017-0691-4)

McCarroll, C. S. et al. (2018) Runx1 deficiency protects against adverse cardiac remodeling after myocardial infarction. Circulation, 137, pp. 57-70. (doi: 10.1161/CIRCULATIONAHA.117.028911)

Rodrigues, A. L., Brescia, M., Kolshinski, A., Moreira, T. H., Cameron, R. T., Baillie, G., Beirão, P. S.L., Zaccollo, M., Cruz, J. S. (2018) Increase in Ca2+ current by sustained cAMP levels enhances proliferation rate in GH3 cells. Life Sciences, 192, pp. 144-150. (doi: 10.1016/j.lfs.2017.11.040)

Bihlmeyer, N. A. et al. (2018) ExomeChip-wide analysis of 95 626 individuals identifies 10 novel loci associated with QT and JT intervals. Circulation: Genomic and Precision Medicine, 11, (doi: 10.1161/CIRCGEN.117.001758)

Turcot, V. et al. (2018) Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nature Genetics, 50, pp. 26-41. (doi: 10.1038/s41588-017-0011-x)

Maznyczka, A. M., McCartney, P., Berry, C. (2018) Reference invasive tests of microvascular injury in myocardial infarction. BMJ Open, 104, pp. 90-92. (doi: 10.1136/heartjnl-2017-311695)

Lee, M. M.Y. et al. (2018) Routine Non-invasive vs Invasive Management in Patients With Prior CABG With a NSTE-ACS: a Randomised Controlled Trial. (doi: 10.1136/heartjnl-2018-BCIS.9)

Souteyrand, G., Valladier, M., Amabile, N., Derimay, F., Harbaoui, B., Leddet, P., Barnay, P., Malcles, G., Mulliez, A., Berry, C., Eschalier, R., Combaret, N., Motreff, P. (2018) Diagnosis and management of spontaneously recanalized coronary thrombus guided by optical coherence tomography ― lessons from the French “Lotus Root” registry ― Circulation Journal, 82, pp. 783-790. (doi: 10.1253/circj.cj-17-0810)

Yalla, K., Elliott, C., Day, J.P., Findlay, J., Barratt, S., Hughes, Z.A., Wilson, L., Whiteley, E., Popiolek, M., Li, Y., Dunlop, J., Killick, R., Adams, D.R., Brandon, N.J., Houslay, M.D., Hao, B., Baillie, G.S. (2018) FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system. Molecular Psychiatry, 23, pp. 1278-1286. (doi: 10.1038/mp.2017.138)

Padmanabhan, S., Tan, L.-E., Dominiczak, A. F. (2018) Genetics of blood pressure and hypertension. Springer

Berry, C., Carberry, J., Mangion, K. (2018) How to mend a broken heart? JACC: Cardiovascular Imaging, 11, pp. 420-422. (doi: 10.1016/j.jcmg.2017.02.017)

Layland, J., Tong, D., Lee, M., Berry, C. (2018) ST and T-Wave Abnormality as Footprint of Myocardial Oedema in Non–ST-Elevation Myocardial Infarction. (doi: 10.1016/j.hlc.2018.06.515)

Delles, C., Carrick, E., Graham, D., Nicklin, S. A. (2018) Utilising proteomics to understand and define hypertension: where are we and where do we go? Expert Review of Proteomics, 15, pp. 581-592. (doi: 10.1080/14789450.2018.1493927)

2017

Avtaar Singh, S. S., Das De, S., Spadaccio, C., Berry, C., Al-Attar, N. (2017) An overview of different methods of myocardial protection currently employed peri-transplantation. Vessel Plus, 1, pp. 213-229. (doi: 10.20517/2574-1209.2017.26)

Van't Veer, M., Pijls, N. H.J., Hennigan, B., Watkins, S., Ali, Z. A., De Bruyne, B., Zimmermann, F. M., van Nunen, L. X., Barbato, E., Berry, C., Oldroyd, K. G. (2017) Comparison of different diastolic resting indexes to iFR: are they all equal? Journal of the American College of Cardiology, 70, pp. 3088-3096. (doi: 10.1016/j.jacc.2017.10.066)

Ford, T. J., Berry, C., De Bruyne, B., Yong, A. C.S., Barlis, P., Fearon, W. F., Ng, M. K.C. (2017) Physiological predictors of acute coronary syndromes: emerging insights from the plaque to the vulnerable patient. JACC: Cardiovascular Interventions, 10, pp. 2539-2547. (doi: 10.1016/j.jcin.2017.08.059)

Berry, C., McClure, J. D., Oldroyd, K. G. (2017) Meta-analysis of death and myocardial infarction in the DEFINE-FLAIR and iFR-SWEDEHEART trials: a hypothesis generating note of caution. Circulation, 136, pp. 2389-2391. (doi: 10.1161/CIRCULATIONAHA.117.030430)

Urimubenshi, G., Langhorne, P., Cadilhac, D. A., Kagwiza, J. N., Wu, O. (2017) Association between patient outcomes and key performance indicators of stroke care quality: A systematic review and meta-analysis. European Stroke Journal, 2, pp. 287-307. (doi: 10.1177/2396987317735426)

Basole, C. P., Nguyen, R. K., Lamothe, K., Vang, A., Clark, R., Baillie, G. S., Epstein, P. M., Brocke, S. (2017) PDE8 controls CD4(+) T cell motility through the PDE8A-Raf-1 kinase signaling complex. Cellular Signalling, 40, pp. 62-72. (doi: 10.1016/j.cellsig.2017.08.007)

Carberry, J., Carrick, D., Haig, C., Ahmed, N., Mordi, I., McEntegart, M., Petrie, M. C., Eteiba, H., Hood, S., Watkins, S., Lindsay, M., Davie, A., Mahrous, A., Ford, I., Sattar, N., Welsh, P., Radjenovic, A., Oldroyd, K. G., Berry, C. (2017) Persistence of infarct zone T2 hyperintensity at 6 months after acute ST-elevation myocardial infarction: incidence, pathophysiology and prognostic implications. Circulation: Cardiovascular Imaging, 10, (doi: 10.1161/CIRCIMAGING.117.006586)

O'Neill, D.G., Riddell, A., Church, D.B., Owen, L., Brodbelt, D.C., Hall, J.L. (2017) Urinary incontinence in bitches under primary veterinary care in England: prevalence and risk factors. Journal of Small Animal Practice, 58, pp. 685-693. (doi: 10.1111/jsap.12731)

Krochmal, M., Kontostathi, G., Magalhães, P., Makridakis, M., Klein, J., Husi, H., Leierer, J., Mayer, G., Bascands, J.-L., Denis, C., Zoidakis, J., Zürbig, P., Delles, C., Schanstra, J. P., Mischak, H., Vlahou, A. (2017) Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy. Scientific Reports, 7, (doi: 10.1038/s41598-017-15359-9)

MacDonald, T. M., Williams, B., Webb, D. J., Morant, S., Caulfield, M., Cruickshank, J. K., Ford, I., Sever, P., Mackenzie, I. S., Padmanabhan, S., McCann, G. P., Salsbury, J., McInnes, G., Brown, M. J. (2017) Combination therapy is superior to sequential monotherapy for the initial treatment of hypertension: a double-blind randomized controlled trial. Journal of the American Heart Association, 6, (doi: 10.1161/JAHA.117.006986)

Mary, S., Kulkarni, M. J., Mehendale, S. S., Joshi, S. R., Giri, A. P. (2017) Differential accumulation of vimentin fragments in preeclamptic placenta. Cytoskeleton, 74, pp. 420-425. (doi: 10.1002/cm.21390)

MacDonald, E. A., Stoyek, M. R., Rose, R. A., Quinn, T. A. (2017) Intrinsic regulation of sinoatrial node function and the zebrafish as a model of stretch effects on pacemaking. Progress in Biophysics and Molecular Biology, 130, pp. 198-211. (doi: 10.1016/j.pbiomolbio.2017.07.012)

Pontillo, C. et al. (2017) Prediction of chronic kidney disease stage 3 by CKD273, a urinary proteomic biomarker. Kidney International Reports, 2, pp. 1066-1075. (doi: 10.1016/j.ekir.2017.06.004)

Schmieder, R. E., Wagner, F., Mayr, M., Delles, C., Ott, C., Keicher, C., Hrabak-Paar, M., Heye, T., Aichner, S., Khder, Y., Yates, D., Albrecht, D., Langenickel, T., Freyhardt, P., Janka, R., Bremerich, J. (2017) The effect of sacubitril/valsartan compared to olmesartan on cardiovascular remodelling in subjects with essential hypertension: the results of a randomized, double-blind, active-controlled study. European Heart Journal, 38, pp. 3308-3317. (doi: 10.1093/eurheartj/ehx525)

Rutherford, E., Mangion, K., Mccomb, C., Bell, E., Cockburn, S., Talle, M., Roditi, G., Welsh, P., Woodward, R., Radjenovic, A., Struthers, A. D., Jardine, A., Berry, C., Patel, R. K., Mark, P. B. (2017) Myocardial changes in incident haemodialysis patients over 6-months: an observational cardiac magnetic resonance imaging study. Scientific Reports, 7, (doi: 10.1038/s41598-017-14481-y)

Kobayashi, Y., Johnson, N. P., Zimmermann, F. M., Witt, N., Berry, C., Jeremias, A., Koo, B.-K., Esposito, G., Rioufol, G., Park, S.-J., Nishi, T., Choi, D.-H., Oldroyd, K. G., Barbato, E., Pijls, N. H. J., De Bruyne, B., Fearon, W. F. (2017) Agreement of the resting distal to aortic coronary pressure with the instantaneous wave-free ratio. Journal of the American College of Cardiology, 70, pp. 2105-2113. (doi: 10.1016/j.jacc.2017.08.049)

Shepperd, S., Cradduck-Bamford, A., Butler, C., Ellis, G., Godfrey, M., Gray, A., Hemsley, A., Khanna, P., Langhorne, P., McCaffrey, P., Mirza, L., Pushpangadan, M., Ramsay, S., Schiff, R., Stott, D., Young, J., Yu, L.-M. (2017) A multi-centre randomised trial to compare the effectiveness of geriatrician-led admission avoidance hospital at home versus inpatient admission. Trials, 18, (doi: 10.1186/s13063-017-2214-y)

Lemonidis, K., MacLeod, R., Baillie, G. S., Chamberlain, L. H. (2017) Peptide array based screening reveals a large number of proteins interacting with the ankyrin repeat domain of the zDHHC17 S-acyltransferase. Journal of Biological Chemistry, 292, pp. 17190-17202. (doi: 10.1074/jbc.M117.799650)

Gao, H., Mangion, K., Carrick, D., Husmeier, D., Luo, X., Berry, C. (2017) Estimating prognosis in patients with acute myocardial infarction using personalized computational heart models. Scientific Reports, 7, (doi: 10.1038/s41598-017-13635-2)

Kohli-Lynch, C.N., Boyd, K., Briggs, A., Delles, C. (2017) A Framework for the Cost-Effectiveness Analysis of Novel Biomarker Testing in Cardiovascular Disease. (doi: 10.1016/j.jval.2017.08.040)

Stevens, K., Denby, L., Patel, R. K., Mark, P. B., Kettlewell, S., Smith, G. L., Clancy, M. J., Delles, C., Jardine, A. G. (2017) Deleterious effects of phosphate on vascular and endothelial function via disruption to the nitric oxide pathway. Nephrology Dialysis Transplantation, 32, pp. 1617-1627. (doi: 10.1093/ndt/gfw252)

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2016

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Havekes, R., Park, A. J., Tolentino, R. E., Bruinenberg, V. M., Tudor, J. C., Lee, Y., Hansen, R. T., Guercio, L. A., Linton, E., Neves, S. R., Meerlo, P., Baillie, G. W., Houslay, M. D., Abel, T. (2016) Compartmentalized PDE4A5 signaling impairs hippocampal synaptic plasticity and long-term memory. Journal of Neuroscience, 36, pp. 8936-8946. (doi: 10.1523/JNEUROSCI.0248-16.2016)

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Rankinen, T. et al. (2016) No evidence of a common DNA variant profile specific to world class endurance athletes. PLoS ONE, 11, (doi: 10.1371/journal.pone.0147330)

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Baillie, G. S., Christian, F., Zarros, A. (2016) Editorial: frontiers in the pharmacological manipulation of intracellular cAMP levels. Frontiers in Pharmacology, 7, (doi: 10.3389/fphar.2016.00004)

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2015

Cameron, A. C., Touyz, R. M., Lang, N. N. (2015) Vascular complications of cancer chemotherapy. Canadian Journal of Cardiology, 32, pp. 852-862. (doi: 10.1016/j.cjca.2015.12.023)

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Smith, C. J., Kishore, A. K., Vail, A., Chamorro, A., Garau, J., Hopkins, S. J., Di Napoli, M., Kalra, L., Langhorne, P., Montaner, J., Roffe, C., Rudd, A. G., Tyrrell, P. J., van de Beek, D., Woodhead, M., Meisel, A. (2015) Diagnosis of stroke-associated pneumonia recommendations from the pneumonia in stroke consensus group. Stroke, 46, pp. 2335-2340. (doi: 10.1161/strokeaha.115.009617)

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Gao, H., Qi, N., Ma, X., Griffith, B. E., Berry, C., Luo, X. (2015) Fluid-structure interaction model of human mitral valve within left ventricle. Springer International Publishing

Divorty, N., Mackenzie, A., Nicklin, S., Milligan, G. (2015) G protein-coupled receptor 35: an emerging target in inflammatory and cardiovascular disease. Frontiers in Pharmacology, 6, (doi: 10.3389/fphar.2015.00041)

Lopez, L. M., Hill, W. D., Harris, S. E., Valdes Hernandez, M., Munoz Maniega, S., Bastin, M. E., Bailey, E., Smith, C., McBride, M., McClure, J., Graham, D., Dominiczak, A., Yang, Q., Fornage, M., Ikram, M. A., Debette, S., Launer, L., Bis, J. C., Schmidt, R., Seshadri, S., Porteous, D. J., Starr, J., Deary, I. J., Wardlaw, J. M. (2015) Genes from a translational analysis support a multifactorial nature of white matter hyperintensities. Stroke, 46, pp. 341-347. (doi: 10.1161/STROKEAHA.114.007649)

Mistry, H.D., Eisele, N., Escher, G., Dick, B., Surbek, D., Delles, C., Currie, G., Schlembach, D., Mohaupt, M.G., Gennari-Moser, C. (2015) Gestation-specific reference intervals for comprehensive spot urinary steroid hormone metabolite analysis in normal singleton pregnancy and 6 weeks postpartum. Reproductive Biology and Endocrinology, 13, (doi: 10.1186/s12958-015-0100-6)

Escola-Gil, J.C., Julve, J., Griffin, B.A., Freeman, D.J., Blanco-Vaca, F. (2015) HDL and lifestyle interventions. Springer Open

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Gao, H., Berry, C., Luo, X. (2015) Image-derived human left ventricular modelling with fluid-structure interaction. Springer International Publishing

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Mangion, K., Carrick, D., Payne, A., McClure, J., Mason, M., Petrie, M., McEntegart, M., Eteiba, H., Oldroyd, K., Berry, C. (2015) Infarct burden following multivessel PCI vs. infarct-only PCI in patients with acute STEMI: the Glasgow PRAMI CMR sub-study. Journal of Cardiovascular Magnetic Resonance, 17, (doi: 10.1186/1532-429X-17-S1-O9)

Souteyrand, G., Amabile, N., Combaret, N., Hammas, S., Prati, F., Berry, C., Pereira, B., Lusson, J.-R., Caussin, C., Motreff, P. (2015) Invasive management without stents in selected acute coronary syndrome patients with a large thrombus burden: a prospective study of optical coherence tomography guided treatment decisions. EuroIntervention, 11, pp. 895-904. (doi: 10.4244/eijy14m07_18)

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Mangion, K., Carrick, D., Payne, A. R., McClure, J., Mason, M., Petrie, M., McEntegart, M., Eteiba, H., Oldroyd, K. G., Berry, C. (2015) Left ventricular outcomes following multivessel PCI vs. infarct artery-only PCI in patients with acute STEMI: the Glasgow PRAMI CMR sub-study. Journal of Cardiovascular Magnetic Resonance, 17, (doi: 10.1186/1532-429X-17-S1-P104)

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Despite substantial progress in our knowledge and management of blood pressure, hypertension remains one of the most important modifiable cardiovascular risk factors. The importance of hypertension is such that in a national report the condition was named ‘Scotland’s Silent Killer’.

The University of Glasgow has a proud tradition of hypertension research, and this continues in the School of Cardiovascular and Metabolic Health. Our bench, to bedside, to population approach has resulted in a new understanding of the pathophysiology of hypertension and the identification of potential new targets for intervention. In our labs, we use techniques spanning from molecular biology and cellular assays to transgenic mouse models, myography, and blood pressure telemetry. While others in the team translate these findings to clinical trials and public health work.  

An exemplar of our approach can be seen in our aldosterone focused research. The hormone aldosterone is a key regulator of the cardiovascular system but its role as an important and treatable driver of hypertension has been poorly appreciated. By improving our understanding of how aldosterone production is regulated within the healthy human body and how this regulation can break down, we aim to improve diagnosis and treatment.

Our work goes beyond the laboratories and team members have had pivotal roles in creating clinical guidelines and raising standards in blood pressure assessment and treatment. There is still an enormous amount of work to do, as at presnet one-third of adults in Scotland have high blood pressure and only around one-quarter of these people are on adequate treatment. In addition to our science, we are actively involved in public engagement events with a focus on blood pressure management and lifestyle-based reductions.

Current areas:

  • Role of sodium and uromodulin in the pathogenesis of hypertension.
  • Asymmetric dimethylarginine (ADMA) is a risk factor and therapeutic target through its action on the nitric oxide synthase family of enzymes.
  • The use "omics" (proteomics, metabolomics, transcriptomics and epigenomics) AI (machine learning), systems biology and bioinformatics in the diagnosis of hypertension.
  • Laboratory-based analysis focused on a better understanding of the regulatory pathways that control aldosterone secretion by the adrenal cortex and its action on vascular cells.
  • Clinical trials that seek to explore how common genetic differences in the human population affect aldosterone production and predispose certain individuals to increased risk of hypertension.
  • Bioinformatic analysis of our data, using cutting-edge AI and pathway-based approaches to identify novel pathways and biomarkers for future research.
  • Hypertension and lifetime cardiovascular risk.