Dr Matthew Walker

  • Research Associate (Biomedical Engineering)

Biography

In 2014 I received my Bachelor's degree in Biology from the University of Hull with upper second class honours (68.5%)

After my Bachelor's degree, I joined the research group of Dr. Daniel Ungar at the University of York to undertake an MRes involving the characterisation of glycosylation mutants in Drosophila melanogaster. Following the completion of my MRes in 2015, I was accepted onto an EPSRC-funded studentship at the University of York to undertake a 3-year PhD supervised by Dr. Daniel UngarProf. Paul GeneverDr. Victor Chechik and Dr. Andrew Pratt. This was a highly interdisciplinary project across the departments of Biology, Chemistry, Physics and Electronics focusing on the development of magnetically-responsive nanoparticles for the delivery of bioactive therapeutics in joint disease.

The introduction of biomaterials and tissue engineering during my PhD research sparked my interest in their possibilities for cross-disciplinary translational research and motivated me to continue researching in these fields.

In 2019, I joined the Biomedical Engineering Research Division at the University of Glasgow to work as a postdoctoral researcher with Dr. Marco Cantini before continuing with Prof. Delphine Gourdon.

My work is carried out within the Centre for the Cellular Microenvironment (CeMi), a multidisciplinary university initiative combining the expertise of cell biologists and bioengineers across the James Watt School of Engineering and College of Medical, Veterinary and Life Sciences (MVLS). The CeMi is co-directed by Prof. Matt Dalby and Prof. Manuel Salmeron-Sanchez and is part of the Acellular/Smart Materials Hub of the United Kingdom Regenerative Medicine Platform (UKRMP).

Research interests

My research focuses on engineering hydrogel microenvironments to study cell interactions with the extracellular matrix. I am interested in mechanosensitive regulation of cell behaviour and differentiation for tissue engineering applications in regenerative medicine and modelling disease pathologies.

Publications

List by: Type | Date

Jump to: 2023 | 2022 | 2021 | 2020 | 2018 | 2017
Number of items: 9.

2023

Walker, M. , Pringle, E. W., Ciccone, G., Oliver Cervello, L., Tassieri, M. , Gourdon, D. and Cantini, M. (2023) Mind the viscous modulus: the mechanotransductive response to the viscous nature of isoelastic matrices regulates stem cell chondrogenesis. Advanced Healthcare Materials, (doi: 10.1002/adhm.202302571) (PMID:38014647) (Early Online Publication)

2022

Luo, J., Walker, M. , Xiao, Y., Donnelly, H., Dalby, M. J. and Salmeron-Sanchez, M. (2022) The influence of nanotopography on cell behaviour through interactions with the extracellular matrix – a review. Bioactive Materials, 15, pp. 145-159. (doi: 10.1016/j.bioactmat.2021.11.024)

Asadishekari, M., Mpoyi, E. N., Li, Y., Eslami, J., Walker, M. , Cantini, M. and Gourdon, D. (2022) Three-dimensional tunable fibronectin-collagen platforms for control of cell adhesion and matrix deposition. Frontiers in Physics, 10, 806554. (doi: 10.3389/fphy.2022.806554)

2021

McDowall, D., Walker, M. , Vassalli, M. , Cantini, M. , Khunti, N., Edwards-Gayle, C. J. C., Cowieson, N. and Adams, D. J. (2021) Controlling the formation and alignment of low molecular weight gel ‘noodles’. Chemical Communications, 57(70), pp. 8782-8785. (doi: 10.1039/D1CC03378F) (PMID:34378594)

Witte, K., Luo, J., Walker, M. , Cantini, M. , Seib, F.P. and Salmeron-Sanchez, M. (2021) Bioinspired and bioinstructive surfaces to control mesenchymal stem cells. In: Azevedo, H. S., Mano, J. F. and Borges, J. (eds.) Soft Matter for Biomedical Applications. Series: Soft matter series (13). Royal Society of Chemistry: Cambridge, pp. 301-325. ISBN 9781788017572 (doi: 10.1039/9781839161124-00301)

Walker, M. , Luo, J., Pringle, E. W. and Cantini, M. (2021) ChondroGELesis: hydrogels to harness the chondrogenic potential of stem cells. Materials Science and Engineering C: Materials for Biological Applications, 121, 111822. (doi: 10.1016/j.msec.2020.111822) (PMID:33579465)

2020

Walker, M. , Will, I., Pratt, A., Chechik, V., Genever, P. and Ungar, D. (2020) Magnetically triggered release of entrapped bioactive proteins from thermally responsive polymer-coated iron oxide nanoparticles for stem-cell proliferation. ACS Applied Nano Materials, 3(6), pp. 5008-5013. (doi: 10.1021/acsanm.0c01167) (PMID:32626842) (PMCID:PMC7325428)

2018

Wilson, K. M., Jagger, A. M., Walker, M. , Seinkmane, E., Fox, J. M., Kröger, R., Genever, P. and Ungar, D. (2018) Glycans modify mesenchymal stem cell differentiation to impact on the function of resulting osteoblasts. Journal of Cell Science, 131(4), jcs209452. (doi: 10.1242/jcs.209452) (PMID:29361539) (PMCID:PMC5868951)

2017

Skeene, K., Walker, M. , Clarke, G., Bergström, E., Genever, P., Ungar, D. and Thomas-Oates, J. (2017) One filter, one sample, and the N- and O-glyco(proteo)me: toward a system to study disorders of protein glycosylation. Analytical Chemistry, 89(11), pp. 5840-5849. (doi: 10.1021/acs.analchem.7b00143) (PMID:28453257)

This list was generated on Sun Apr 14 18:25:15 2024 BST.
Number of items: 9.

Articles

Walker, M. , Pringle, E. W., Ciccone, G., Oliver Cervello, L., Tassieri, M. , Gourdon, D. and Cantini, M. (2023) Mind the viscous modulus: the mechanotransductive response to the viscous nature of isoelastic matrices regulates stem cell chondrogenesis. Advanced Healthcare Materials, (doi: 10.1002/adhm.202302571) (PMID:38014647) (Early Online Publication)

Luo, J., Walker, M. , Xiao, Y., Donnelly, H., Dalby, M. J. and Salmeron-Sanchez, M. (2022) The influence of nanotopography on cell behaviour through interactions with the extracellular matrix – a review. Bioactive Materials, 15, pp. 145-159. (doi: 10.1016/j.bioactmat.2021.11.024)

Asadishekari, M., Mpoyi, E. N., Li, Y., Eslami, J., Walker, M. , Cantini, M. and Gourdon, D. (2022) Three-dimensional tunable fibronectin-collagen platforms for control of cell adhesion and matrix deposition. Frontiers in Physics, 10, 806554. (doi: 10.3389/fphy.2022.806554)

McDowall, D., Walker, M. , Vassalli, M. , Cantini, M. , Khunti, N., Edwards-Gayle, C. J. C., Cowieson, N. and Adams, D. J. (2021) Controlling the formation and alignment of low molecular weight gel ‘noodles’. Chemical Communications, 57(70), pp. 8782-8785. (doi: 10.1039/D1CC03378F) (PMID:34378594)

Walker, M. , Luo, J., Pringle, E. W. and Cantini, M. (2021) ChondroGELesis: hydrogels to harness the chondrogenic potential of stem cells. Materials Science and Engineering C: Materials for Biological Applications, 121, 111822. (doi: 10.1016/j.msec.2020.111822) (PMID:33579465)

Walker, M. , Will, I., Pratt, A., Chechik, V., Genever, P. and Ungar, D. (2020) Magnetically triggered release of entrapped bioactive proteins from thermally responsive polymer-coated iron oxide nanoparticles for stem-cell proliferation. ACS Applied Nano Materials, 3(6), pp. 5008-5013. (doi: 10.1021/acsanm.0c01167) (PMID:32626842) (PMCID:PMC7325428)

Wilson, K. M., Jagger, A. M., Walker, M. , Seinkmane, E., Fox, J. M., Kröger, R., Genever, P. and Ungar, D. (2018) Glycans modify mesenchymal stem cell differentiation to impact on the function of resulting osteoblasts. Journal of Cell Science, 131(4), jcs209452. (doi: 10.1242/jcs.209452) (PMID:29361539) (PMCID:PMC5868951)

Skeene, K., Walker, M. , Clarke, G., Bergström, E., Genever, P., Ungar, D. and Thomas-Oates, J. (2017) One filter, one sample, and the N- and O-glyco(proteo)me: toward a system to study disorders of protein glycosylation. Analytical Chemistry, 89(11), pp. 5840-5849. (doi: 10.1021/acs.analchem.7b00143) (PMID:28453257)

Book Sections

Witte, K., Luo, J., Walker, M. , Cantini, M. , Seib, F.P. and Salmeron-Sanchez, M. (2021) Bioinspired and bioinstructive surfaces to control mesenchymal stem cells. In: Azevedo, H. S., Mano, J. F. and Borges, J. (eds.) Soft Matter for Biomedical Applications. Series: Soft matter series (13). Royal Society of Chemistry: Cambridge, pp. 301-325. ISBN 9781788017572 (doi: 10.1039/9781839161124-00301)

This list was generated on Sun Apr 14 18:25:15 2024 BST.

Grants

  • Scottish Universities Life Sciences Alliance (SULSA), SULSA ECR Prize, 'Engineering pancreatic tumour viscoelasticity', 2022-2023, £3k

Supervision

Co-supervision of PhD candidates:

  • Eonan William Pringle - Dissipative microenvironments to understand cell response to viscosity (expected 2024)
  • Omalola Ajayi - Engineered microenvironments for multiscale mechanobiology of breast cancer (expected 2025)
  • Konstantina Soulioti - Correlating viscoelasticity and microstructure of the tumour environment to enable early detection, diagnosis and invasion of breast cancer (expected 2025)

Co-supervision of MSc students:

  • Muhd Hazim Rusyduddin Abd Hadi - Correlating hydrogel viscoelasticity and protein coating with cell mechanosensing (completed 2021)
  • Thi Thuy Trang Le - Viscoelastic hydrogels for the control of stem cell fate (completed 2022)
  • Nandana Shankar - Viscoelastic hydrogels for cartilage tissue engineering (completed 2022)
  • Manasvi Sheta - Regulation of breast cancer cells on healthy and tumour-mimetic viscoelastic hydrogels (completed 2022)
  • Laura Webster - Viscoelastic hydrogels for mimicking the tumour environment (completed 2022)
  • Julia Brown Casquet - Dynamic surfaces for the control of cancer cells survival and tumour progression (competed 2022)
  • Antonella Passcuci - Investigating the mechanobiology of pancreatic ductal adenocarcinoma (completed 2023)

Co-supervision of BEng students:

  • Ngai Ming Chu - Torsional force microscopy using photothermal excition (expected 2024)
  • Kiflom Brhane - Development of a tensile tester to perform aqueous mechanical measurements (expected 2024)