Dr Matthew Walker
- Research Associate (Biomedical Engineering)
In 2014 I received my Bachelor's degree in Biology from the University of Hull with upper second class honours (68.5%)
After my Bachelor's degree, I joined the research group of Dr. Daniel Ungar at the University of York to undertake an MRes involving the characterisation of glycosylation mutants in Drosophila melanogaster. Following the completion of my MRes in 2015, I was accepted onto an EPSRC-funded studentship at the University of York to undertake a 3-year PhD supervised by Dr. Daniel Ungar, Prof. Paul Genever, Dr. Victor Chechik and Dr. Andrew Pratt. This was a highly interdisciplinary project across the departments of Biology, Chemistry, Physics and Electronics focusing on the development of magnetically-responsive nanoparticles for the delivery of bioactive therapeutics in joint disease.
The introduction of biomaterials and tissue engineering during my PhD research sparked my interest in their possibilities for cross-disciplinary translational research and motivated me to continue researching in these fields.
My work is carried out within the Centre for the Cellular Microenvironment (CeMi), a multidisciplinary university initiative combining the expertise of cell biologists and bioengineers across the James Watt School of Engineering and College of Medical, Vetinary and Life Sciences (MVLS). The CeMi is co-directed by Prof. Matt Dalby and Prof. Manuel Salmeron-Sanchez and is part of the Acellular/Smart Materials Hub of the United Kingdom Regenerative Medicine Platform (UKRMP).
My research focuses on engineering hydrogel microenvironments to study cell interactions with the extracellular matrix. I am interested in mechanosensitive regulation of cell behaviour and differentiation for tissue engineering applications in regenerative medicine and modelling disease pathologies.
- Scottish Universities Life Sciences Alliance (SULSA), SULSA ECR Prize, 'Engineering pancreatic tumour viscoelasticity', 2022-2023, £3k
Co-supervision of PhD candidates:
- Eonan William Pringle - Dissipative microenvironments to understand cell response to viscosity (expected 2024)
- Omalola Ajayi - Engineered microenvironments for multiscale mechanobiology of breast cancer (expected 2025)
- Konstantina Soulioti - Correlating viscoelasticity and microstructure of the tumour environment to enable early detection, diagnosis and invasion of breast cancer (expected 2025)