Dr Marco Cantini

  • MRC/UKRI Rutherford Fund Fellow (Biomedical Engineering)

Research interests

In 2018, I was awarded a UKRI Rutherford Fund Fellowship, granted by the MRC in alignment with the UK Regenerative Medicine Platform (UKRMP) initiative.

My work, based at the Biomedical Engineering Research Division of the University of Glasgow, is carried out within the Centre for the Cellular Microenvironment, a cross-college multidisciplinary initiative of the University, and the Acellular/Smart Materials Hub of the UKRMP.

My current research seeks to engineer microenvironments to harvest stem cell response to viscosity, in particular for the promotion of chondrogenic differentiation for cartilage repair.

My research interests include the design of biointerfaces and microenvironments to simulate the spatio-temporal cues of the extracellular matrix in both physiological and pathological conditions, for applications in regenerative medicine, drug testing and understanding disease mechanisms. I'm also interested in protein adsorption, cell adhesion, stem cell differentiation, atomic force microscopy and spectroscopy.

Biography

In 2004 I received my Bachelor and in 2006 my Master degree in Biomedical Engineering from Politecnico di Milano and Politecnico di Torino in Italy, with full marks and honours. I then graduated from the school for young talents Alta Scuola Politecnica in 2007.

Between 2007 and 2010 I pursued a PhD in Biomedical and Biomechanical Engineering through a joint PhD program (Scuola Interpolitecnica) of the three Italian Technical Universities. I then held post-doctoral researcher positions at the Universitat Politècnica de València and at the Institute for Bioengineering of Catalonia in Spain, focussing my interest on the modulation of cell-protein-material interactions to control cell fate.

In 2013, I moved to the University of Glasgow, where I have been working on material-based strategies to engineer tissue repair and regeneration as a Research Associate in the Microenvironments for Medicine group led by Professor Manuel Salmeron-Sanchez and as a Research Fellow since 2018.


Selected publications


Grants

  • Medical Research Council (UK), UKRI Innovation/Rutherford Fund Fellowship, Engineered microenvironments to harvest stem cell response to viscosity for cartilage repair, MR/S005412/1, 2018-2021, £600k
  • Ministero dell’Istruzione, dell’Università e della Ricerca (Italy), Doctoral Scolarship, Design of a dynamic culture system for the in vitro mimicry of the bone marrow microenvironment, 2007-2009, €45k

Supervision

Co-supervision of PhD candidates:

  • Haoming Wang (Viscosity in the integrin-growth factor cross-talk, expected 2022)
  • Eva Barcelona Estaje (Engineering surface mobility to control stem cell differentiation, expected 2021)
  • Vassilis Papalazarou (Bioengineering microenvironments for pancreatic cancer cell invasion, expected 2019)
  • Mark Sprott (Synergistic microenvironments to control stem cell fate, expected 2019)
  • Mark Bennett (Mobility dependent cellular behaviour on supported lipid bilayers, 2014-2018)
  • Elie Ngandu Mpoyi (Engineering biointerfaces to reveal collagen IV disease mechanisms, 2014-2017)
  • Frankie Vanterpool (Deconstructing the tumour microenvironment: the role of fibronectin, 2013-2017)
  • Eleni Grigoriou (Graded organisation of fibronectin to tune cell behaviour, 2013-2017)
  • Fatma Bathawab (Engineering surface mobility to direct stem cell fate, 2013-2017)

Teaching

Biomechanics 3/M


All publications

List by: Type | Date

Jump to: 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2009 | 2008 | 2007
Number of items: 29.

2019

Re, F. et al. (2019) 3D gelatin-chitosan hybrid hydrogels combined with human platelet lysate highly support human mesenchymal stem cell proliferation and osteogenic differentiation. Journal of Tissue Engineering, (Accepted for Publication)

Sprott, M. R., Gallego-Ferrer, G., Dalby, M. J. , Salmeron-Sanchez, M. and Cantini, M. (2019) Functionalisation of PLLA with polymer brushes to trigger the assembly of fibronectin into nanonetworks. Advanced Healthcare Materials, 8(3), 1801469. (doi:10.1002/adhm.201801469) (PMID:30609243)

2018

Cheng, Z. A. et al. (2018) Nanoscale coatings for ultralow dose BMP‐2‐driven regeneration of critical‐sized bone defects. Advanced Science, (doi:10.1002/advs.201800361) (Early Online Publication)

Gonzalez Garcia, C., Cantini, M. , Ballester-Beltran, J., Altankov, G. and Salmeron-Sanchez, M. (2018) The strength of the protein-material interaction determines cell fate. Acta Biomaterialia, 77, pp. 74-84. (doi:10.1016/j.actbio.2018.07.016) (PMID:30006313)

Bennett, M., Cantini, M. , Reboud, J. , Cooper, J. M. , Roca-Cusachs, P. and Salmeron-Sanchez, M. (2018) Molecular clutch drives cell response to surface viscosity. Proceedings of the National Academy of Sciences of the United States of America, 115(6), pp. 1192-1197. (doi:10.1073/pnas.1710653115) (PMID:29358406)

2017

Cantini, M. , Gomide, K., Moulisova, V. , González-García, C. and Salmerón-Sánchez, M. (2017) Vitronectin as a micromanager of cell response in material-driven fibronectin nanonetworks. Advanced Biosystems, 1(9), 1700047. (doi:10.1002/adbi.201700047) (PMID:29497701) (PMCID:PMC5822048)

Grigoriou, E. , Cantini, M. , Dalby, M.J. , Petersen, A. and Salmeron-Sanchez, M. (2017) Cell migration on material-driven fibronectin microenvironments. Biomaterials Science, 5(7), 1326. (doi:10.1039/C7BM00333A) (PMID:28612879) (PMCID:PMC5858633)

Moulisová, V. , Gonzalez-Garcia, C., Cantini, M. , Rodrigo-Navarro, A. , Weaver, J., Costell, M., Sabater i Serra, R., Dalby, M. J. , García, A. J. and Salmerón-Sánchez, M. (2017) Engineered microenvironments for synergistic VEGF - integrin signalling during vascularization. Biomaterials, 126, pp. 61-74. (doi:10.1016/j.biomaterials.2017.02.024) (PMID:28279265) (PMCID:PMC5354119)

Gugutkov, D., Gustavsson, J., Cantini, M. , Salmeron-Sanchez, M. and Altankov, G. (2017) Electrospun fibrinogen-PLA nanofibres for vascular tissue engineering. Journal of Tissue Engineering and Regenerative Medicine, 11(10), pp. 2774-2784. (doi:10.1002/term.2172) (PMID:27238477)

2016

Llopis-Hernández, V. , Cantini, M. , González-García, C., Cheng, Z. A., Yang, J., Tsimbouri, P. M. , García, A. J., Dalby, M. J. and Salmerón-Sánchez, M. (2016) Material-driven fibronectin assembly for high-efficiency presentation of growth factors. Science Advances, 2(8), e1600188. (doi:10.1126/sciadv.1600188) (PMID:27574702) (PMCID:PMC5001810)

Ngandu Mpoyi, E., Cantini, M. , Reynolds, P. M. , Gadegaard, N. , Dalby, M. J. and Salmerón-Sánchez, M. (2016) Protein adsorption as a key mediator in the nanotopographical control of cell behavior. ACS Nano, 10(7), pp. 6638-6647. (doi:10.1021/acsnano.6b01649) (PMID:27391047) (PMCID:PMC4980054)

Bathawab, F., Bennett, M., Cantini, M. , Reboud, J. , Dalby, M. and Salmeron-Sanchez, M. (2016) Lateral chain length in polyalkyl acrylates determines the mobility of fibronectin at the cell/material interface. Langmuir, 32(3), pp. 800-809. (doi:10.1021/acs.langmuir.5b03259) (PMID:26715432) (PMCID:PMC4732669)

2015

Marín-Pareja, N., Cantini, M. , Gonzalez-Garcia, C., Salvagni, E., Salmeron-Sanchez, M. and Ginebra, M.-P. (2015) Different organization of type: collagen immobilized on silanized and nonsilanized titanium surfaces affects fibroblast adhesion and fibronectin secretion. ACS Applied Materials and Interfaces, 7(37), 20667. (doi:10.1021/acsami.5b05420) (PMID:26322620)

Llopis-Hernandez, V., Cantini, M. , González-García, C. and Salmeron-Sanchez, M. (2015) Material-based strategies to engineer fibronectin matrices for regenerative medicine. International Materials Reviews, 60(5), pp. 245-264. (doi:10.1179/1743280414Y.0000000049)

2014

Vanterpool, F. A., Cantini, M. , Seib, F. P. and Salmerón-Sánchez, M. (2014) A material-based platform to modulate fibronectin activity and focal adhesion assembly. BioResearch Open Access, 3(6), pp. 286-296. (doi:10.1089/biores.2014.0033)

Rico Tortosa, P., Cantini, M. , Altankov, G. and Salmeron-Sanchez, M. (2014) Matrix protein interactions with synthetic surfaces. In: Pradas, M.M. and Vicent, M.A. (eds.) Polymers in Regenerative Medicine: Biomedical Applications from Nano- to Macro-Structures. Springer, pp. 91-146. ISBN 9780470596388 (doi:10.1002/9781118356692.ch3)

Hochman-Mendez, C., Cantini, M. , Moratal, D., Salmeron-Sanchez, M. and Coelho-Sampaio, T. (2014) A fractal nature for polymerized laminin. PLoS ONE, 9(10), e109388. (doi:10.1371/journal.pone.0109388) (PMID:25296244) (PMCID:PMC4190072)

2013

Gonzalez Garcia, C., Cantini, M. , Moratal, D., Altankov, G. and Salmerón-Sánchez, M. (2013) Vitronectin alters fibronectin organization at the cell–material interface. Colloids and Surfaces B: Biointerfaces, 111(1), pp. 618-625. (doi:10.1016/j.colsurfb.2013.07.016)

Piola, M., Soncini, M., Cantini, M. , Sadr, N., Ferrario, G. and Fiore, G. B. (2013) Design and functional testing of a multichamber perfusion platform for three-dimensional scaffolds. Scientific World Journal, 2013, 123974. (doi:10.1155/2013/123974) (PMID:24453787) (PMCID:PMC3885203)

Cantini, M. , Sousa, M., Moratal, D., Mano, J. F. and Salmeron-Sanchez, M. (2013) Non-monotonic cell differentiation pattern on extreme wettability gradients. Biomaterials Science, 1(2), pp. 202-212. (doi:10.1039/c2bm00063f)

2012

Cantini, M. , Gonzalez-Garcia, C., Llopis-Hernandez, V. and Salmerón-Sánchez, M. (2012) Material-driven fibronectin fibrillogenesis. In: Horbett, T., Brash, B. and Norde, N. (eds.) Proteins at Interfaces III State of the Art 2012. Series: ACS symposium series (1120). American Chemical Society: Washington DC, VA, USA, pp. 471-496. (doi:10.1021/bk-2012-1120.ch022)

Ballester-Beltrán, J., Cantini, M. , Lebourg, M., Rico, P., Moratal, D., García, A.J. and Salmerón-Sánchez, M. (2012) Effect of topological cues on material-driven fibronectin fibrillogenesis and cell differentiation. Journal of Materials Science: Materials in Medicine, 23(1), pp. 195-204. (doi:10.1007/s10856-011-4532-z)

Cantini, M. , Rico, P., Moratal, D. and Salmerón-Sánchez, M. (2012) Controlled wettability, same chemistry: biological activity of plasma-polymerized coatings. Soft Matter, 8(20), pp. 5575-5584. (doi:10.1039/c2sm25413a)

Cantini, M. , Rico, P. and Salmerón-Sánchez, M. (2012) Fibronectin fibrillogenesis at the cell-material interface. In: Mano, J.F. (ed.) Biomimetic Approaches for Biomaterials Development. Wiley: Weinham, Germany. ISBN 9783527329168 (doi:10.1002/9783527652273.ch8)

2009

Cantini, M. , Fiore, G. B., Redaelli, A. and Soncini, M. (2009) CFD-Aided Design of a Dynamic Culture System for the Co-Culture of Adherent and Non-Adherent Cells. ASME 2009 Summer Bioengineering Conference, Lake Tahoe, California, 17-21 June 2009. p. 1067. ISBN 9780791848913 (doi:10.1115/sbc2009-206431)

Politecnico di Milano (2009) Processo per la sintesi di perfluoroalchileteri. .

2008

Cantini, M. , Fiore, G. B., Redaelli, A. and Soncini, M. (2008) Numerical fluid-dynamic optimization of microchannel-provided porous scaffolds for the co-culture of adherent and non-adherent cells. Tissue Engineering Part A, 15(3), pp. 615-623. (doi:10.1089/ten.tea.2008.0027)

Cantini, M. , Fiore, G. B., Redaelli, A. and Soncini, M. (2008) Metabolite Transport Inside Channeled Porous Scaffolds for Haematopoietic Stem Cell Culture: A Computational Study. In: ASME 2008 Summer Bioengineering Conference, Marco Island, Florida, 25-29 June 2008, pp. 481-482. ISBN 9780791843215 (doi:10.1115/SBC2008-192852)

2007

Navarrini, W. et al. (2007) ASP studies on fluorine in biomedicine: two innovative applications. Chimica Oggi = Chemistry Today, 25(3), pp. 48-50.

This list was generated on Sat Apr 20 11:05:50 2019 BST.
Jump to: Articles | Book Sections | Conference or Workshop Item | Conference Proceedings | Patents
Number of items: 29.

Articles

Re, F. et al. (2019) 3D gelatin-chitosan hybrid hydrogels combined with human platelet lysate highly support human mesenchymal stem cell proliferation and osteogenic differentiation. Journal of Tissue Engineering, (Accepted for Publication)

Sprott, M. R., Gallego-Ferrer, G., Dalby, M. J. , Salmeron-Sanchez, M. and Cantini, M. (2019) Functionalisation of PLLA with polymer brushes to trigger the assembly of fibronectin into nanonetworks. Advanced Healthcare Materials, 8(3), 1801469. (doi:10.1002/adhm.201801469) (PMID:30609243)

Cheng, Z. A. et al. (2018) Nanoscale coatings for ultralow dose BMP‐2‐driven regeneration of critical‐sized bone defects. Advanced Science, (doi:10.1002/advs.201800361) (Early Online Publication)

Gonzalez Garcia, C., Cantini, M. , Ballester-Beltran, J., Altankov, G. and Salmeron-Sanchez, M. (2018) The strength of the protein-material interaction determines cell fate. Acta Biomaterialia, 77, pp. 74-84. (doi:10.1016/j.actbio.2018.07.016) (PMID:30006313)

Bennett, M., Cantini, M. , Reboud, J. , Cooper, J. M. , Roca-Cusachs, P. and Salmeron-Sanchez, M. (2018) Molecular clutch drives cell response to surface viscosity. Proceedings of the National Academy of Sciences of the United States of America, 115(6), pp. 1192-1197. (doi:10.1073/pnas.1710653115) (PMID:29358406)

Cantini, M. , Gomide, K., Moulisova, V. , González-García, C. and Salmerón-Sánchez, M. (2017) Vitronectin as a micromanager of cell response in material-driven fibronectin nanonetworks. Advanced Biosystems, 1(9), 1700047. (doi:10.1002/adbi.201700047) (PMID:29497701) (PMCID:PMC5822048)

Grigoriou, E. , Cantini, M. , Dalby, M.J. , Petersen, A. and Salmeron-Sanchez, M. (2017) Cell migration on material-driven fibronectin microenvironments. Biomaterials Science, 5(7), 1326. (doi:10.1039/C7BM00333A) (PMID:28612879) (PMCID:PMC5858633)

Moulisová, V. , Gonzalez-Garcia, C., Cantini, M. , Rodrigo-Navarro, A. , Weaver, J., Costell, M., Sabater i Serra, R., Dalby, M. J. , García, A. J. and Salmerón-Sánchez, M. (2017) Engineered microenvironments for synergistic VEGF - integrin signalling during vascularization. Biomaterials, 126, pp. 61-74. (doi:10.1016/j.biomaterials.2017.02.024) (PMID:28279265) (PMCID:PMC5354119)

Gugutkov, D., Gustavsson, J., Cantini, M. , Salmeron-Sanchez, M. and Altankov, G. (2017) Electrospun fibrinogen-PLA nanofibres for vascular tissue engineering. Journal of Tissue Engineering and Regenerative Medicine, 11(10), pp. 2774-2784. (doi:10.1002/term.2172) (PMID:27238477)

Llopis-Hernández, V. , Cantini, M. , González-García, C., Cheng, Z. A., Yang, J., Tsimbouri, P. M. , García, A. J., Dalby, M. J. and Salmerón-Sánchez, M. (2016) Material-driven fibronectin assembly for high-efficiency presentation of growth factors. Science Advances, 2(8), e1600188. (doi:10.1126/sciadv.1600188) (PMID:27574702) (PMCID:PMC5001810)

Ngandu Mpoyi, E., Cantini, M. , Reynolds, P. M. , Gadegaard, N. , Dalby, M. J. and Salmerón-Sánchez, M. (2016) Protein adsorption as a key mediator in the nanotopographical control of cell behavior. ACS Nano, 10(7), pp. 6638-6647. (doi:10.1021/acsnano.6b01649) (PMID:27391047) (PMCID:PMC4980054)

Bathawab, F., Bennett, M., Cantini, M. , Reboud, J. , Dalby, M. and Salmeron-Sanchez, M. (2016) Lateral chain length in polyalkyl acrylates determines the mobility of fibronectin at the cell/material interface. Langmuir, 32(3), pp. 800-809. (doi:10.1021/acs.langmuir.5b03259) (PMID:26715432) (PMCID:PMC4732669)

Marín-Pareja, N., Cantini, M. , Gonzalez-Garcia, C., Salvagni, E., Salmeron-Sanchez, M. and Ginebra, M.-P. (2015) Different organization of type: collagen immobilized on silanized and nonsilanized titanium surfaces affects fibroblast adhesion and fibronectin secretion. ACS Applied Materials and Interfaces, 7(37), 20667. (doi:10.1021/acsami.5b05420) (PMID:26322620)

Llopis-Hernandez, V., Cantini, M. , González-García, C. and Salmeron-Sanchez, M. (2015) Material-based strategies to engineer fibronectin matrices for regenerative medicine. International Materials Reviews, 60(5), pp. 245-264. (doi:10.1179/1743280414Y.0000000049)

Vanterpool, F. A., Cantini, M. , Seib, F. P. and Salmerón-Sánchez, M. (2014) A material-based platform to modulate fibronectin activity and focal adhesion assembly. BioResearch Open Access, 3(6), pp. 286-296. (doi:10.1089/biores.2014.0033)

Hochman-Mendez, C., Cantini, M. , Moratal, D., Salmeron-Sanchez, M. and Coelho-Sampaio, T. (2014) A fractal nature for polymerized laminin. PLoS ONE, 9(10), e109388. (doi:10.1371/journal.pone.0109388) (PMID:25296244) (PMCID:PMC4190072)

Gonzalez Garcia, C., Cantini, M. , Moratal, D., Altankov, G. and Salmerón-Sánchez, M. (2013) Vitronectin alters fibronectin organization at the cell–material interface. Colloids and Surfaces B: Biointerfaces, 111(1), pp. 618-625. (doi:10.1016/j.colsurfb.2013.07.016)

Piola, M., Soncini, M., Cantini, M. , Sadr, N., Ferrario, G. and Fiore, G. B. (2013) Design and functional testing of a multichamber perfusion platform for three-dimensional scaffolds. Scientific World Journal, 2013, 123974. (doi:10.1155/2013/123974) (PMID:24453787) (PMCID:PMC3885203)

Cantini, M. , Sousa, M., Moratal, D., Mano, J. F. and Salmeron-Sanchez, M. (2013) Non-monotonic cell differentiation pattern on extreme wettability gradients. Biomaterials Science, 1(2), pp. 202-212. (doi:10.1039/c2bm00063f)

Ballester-Beltrán, J., Cantini, M. , Lebourg, M., Rico, P., Moratal, D., García, A.J. and Salmerón-Sánchez, M. (2012) Effect of topological cues on material-driven fibronectin fibrillogenesis and cell differentiation. Journal of Materials Science: Materials in Medicine, 23(1), pp. 195-204. (doi:10.1007/s10856-011-4532-z)

Cantini, M. , Rico, P., Moratal, D. and Salmerón-Sánchez, M. (2012) Controlled wettability, same chemistry: biological activity of plasma-polymerized coatings. Soft Matter, 8(20), pp. 5575-5584. (doi:10.1039/c2sm25413a)

Cantini, M. , Fiore, G. B., Redaelli, A. and Soncini, M. (2008) Numerical fluid-dynamic optimization of microchannel-provided porous scaffolds for the co-culture of adherent and non-adherent cells. Tissue Engineering Part A, 15(3), pp. 615-623. (doi:10.1089/ten.tea.2008.0027)

Navarrini, W. et al. (2007) ASP studies on fluorine in biomedicine: two innovative applications. Chimica Oggi = Chemistry Today, 25(3), pp. 48-50.

Book Sections

Rico Tortosa, P., Cantini, M. , Altankov, G. and Salmeron-Sanchez, M. (2014) Matrix protein interactions with synthetic surfaces. In: Pradas, M.M. and Vicent, M.A. (eds.) Polymers in Regenerative Medicine: Biomedical Applications from Nano- to Macro-Structures. Springer, pp. 91-146. ISBN 9780470596388 (doi:10.1002/9781118356692.ch3)

Cantini, M. , Gonzalez-Garcia, C., Llopis-Hernandez, V. and Salmerón-Sánchez, M. (2012) Material-driven fibronectin fibrillogenesis. In: Horbett, T., Brash, B. and Norde, N. (eds.) Proteins at Interfaces III State of the Art 2012. Series: ACS symposium series (1120). American Chemical Society: Washington DC, VA, USA, pp. 471-496. (doi:10.1021/bk-2012-1120.ch022)

Cantini, M. , Rico, P. and Salmerón-Sánchez, M. (2012) Fibronectin fibrillogenesis at the cell-material interface. In: Mano, J.F. (ed.) Biomimetic Approaches for Biomaterials Development. Wiley: Weinham, Germany. ISBN 9783527329168 (doi:10.1002/9783527652273.ch8)

Conference or Workshop Item

Cantini, M. , Fiore, G. B., Redaelli, A. and Soncini, M. (2009) CFD-Aided Design of a Dynamic Culture System for the Co-Culture of Adherent and Non-Adherent Cells. ASME 2009 Summer Bioengineering Conference, Lake Tahoe, California, 17-21 June 2009. p. 1067. ISBN 9780791848913 (doi:10.1115/sbc2009-206431)

Conference Proceedings

Cantini, M. , Fiore, G. B., Redaelli, A. and Soncini, M. (2008) Metabolite Transport Inside Channeled Porous Scaffolds for Haematopoietic Stem Cell Culture: A Computational Study. In: ASME 2008 Summer Bioengineering Conference, Marco Island, Florida, 25-29 June 2008, pp. 481-482. ISBN 9780791843215 (doi:10.1115/SBC2008-192852)

Patents

Politecnico di Milano (2009) Processo per la sintesi di perfluoroalchileteri. .

This list was generated on Sat Apr 20 11:05:50 2019 BST.


Dr Marco Cantini

School of Engineering, Rankine Building, Oakfield Avenue, Glasgow G128LT, G12 8LT