Research

Chemistry is the central molecular science - it is about everything that has to do with molecules: making them, using their properties to engineer useful things, studying fundamental physics with molecules, and using their physical properties to achieve new effects.

Our staff and students work on projects strongly tied to other disciplines in areas including plasmonics, molecular magnets, battery technology, 3D printing and malaria. Our research is split into six main research groups, detailed below.

Recent publications

Hydra mesoglea proteome identifies thrombospondin as a conserved component active in head organizer restriction

Lommel, M. et al. (2018) Hydra mesoglea proteome identifies thrombospondin as a conserved component active in head organizer restriction. Scientific Reports , 8, 11753. (doi: 10.1038/s41598-018-30035-2 ) (PMID:30082916) (PMCID:PMC6079037)

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Electronic structure study of divanadium complexes with rigid covalent coordination: potential molecular qubits with slow spin relaxation

Sproules, S. (2021) Electronic structure study of divanadium complexes with rigid covalent coordination: potential molecular qubits with slow spin relaxation. Dalton Transactions , 50(14), pp. 4778-4782. (doi: 10.1039/d1dt00709b ) (PMID:33877176)

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Organic transformations using electro-generated polyoxometalate redox mediators

Stergiou, A. D. and Symes, M. D. (2021) Organic transformations using electro-generated polyoxometalate redox mediators. Catalysis Today , (doi: 10.1016/j.cattod.2021.05.003 ) (In Press)

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Pre-existing hypertension and pregnancy induced hypertension reveal molecular differences in placental proteome in rodents

Mary, S. , Small, H. , Herse, F., Carrick, E. , Flynn, A. , Mullen, W. , Dechend, R. and Delles, C. (2021) Pre-existing hypertension and pregnancy induced hypertension reveal molecular differences in placental proteome in rodents. Physiological Genomics , (Accepted for Publication)

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The structural biology of patellamide biosynthesis

Koehnke, J. , Bent, A. F., Houssen, W. E., Mann, G., Jaspars, M. and Naismith, J. H. (2014) The structural biology of patellamide biosynthesis. Current Opinion in Structural Biology , 29, pp. 112-121. (doi: 10.1016/j.sbi.2014.10.006 ) (PMID:25460274) (PMCID:PMC4268494)

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The role of protein–protein interactions in the biosynthesis of ribosomally synthesized and post-translationally modified peptides

Sikandar, A. and Koehnke, J. (2019) The role of protein–protein interactions in the biosynthesis of ribosomally synthesized and post-translationally modified peptides. Natural Product Reports , 36, pp. 1576-1588. (doi: 10.1039/C8NP00064F ) (PMID:30920567)

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New developments in RiPP discovery, enzymology and engineering

Montalbán-López, M. et al. (2020) New developments in RiPP discovery, enzymology and engineering. Natural Product Reports , 38, pp. 130-239. (doi: 10.1039/d0np00027b ) (PMID:32935693)

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An efficient method for the in vitro production of azol(in)e-based cyclic peptides

Houssen, W. E. et al. (2014) An efficient method for the in vitro production of azol(in)e-based cyclic peptides. Angewandte Chemie (International Edition) , 53(51), pp. 14171-14174. (doi: 10.1002/anie.201408082 ) (PMID:25331823) (PMCID:PMC4282754)

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The structure of the cyanobactin domain of unknown function from PatG in the patellamide gene cluster

Mann, G., Koehnke, J. , Bent, A. F., Graham, R., Houssen, W., Jaspars, M., Schwarz-Linek, U. and Naismith, J. H. (2014) The structure of the cyanobactin domain of unknown function from PatG in the patellamide gene cluster. Acta Crystallographica. Section F: Structural Biology Communications , 70, pp. 1597-1603. (doi: 10.1107/s2053230x1402425x ) (PMID:25484206) (PMCID:PMC4259220)

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Polysaccharide nanoparticles: From fabrication to applications

Plucinski, A. , Lyu, Z. and Schmidt, B. V.K.J. (2021) Polysaccharide nanoparticles: From fabrication to applications. Journal of Materials Chemistry B , (doi: 10.1039/D1TB00628B ) (Early Online Publication)

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Automated Radiosynthesis of cis- and trans-4-[18F]Fluoro-L-proline using [18F]Fluoride

Sutherland, A. (2021) Automated Radiosynthesis of cis- and trans-4-[18F]Fluoro-L-proline using [18F]Fluoride. Journal of Organic Chemistry , (Accepted for Publication)

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De novo design of functional co-assembling organic-inorganic hydrogels for hierarchical mineralization and neovascularization

Okesola, B. O. et al. (2021) De novo design of functional co-assembling organic-inorganic hydrogels for hierarchical mineralization and neovascularization. ACS Nano , (Accepted for Publication)

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Urea-urease reaction in controlling properties of supramolecular hydrogels: pros and cons

Panja, S. and Adams, D. J. (2021) Urea-urease reaction in controlling properties of supramolecular hydrogels: pros and cons. Chemistry: A European Journal , (doi: 10.1002/chem.202100490 ) (PMID:33861488) (Early Online Publication)

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Mechanochemical synthesis and structure of lithium tetrahaloaluminates, LiAlX4 (X = Cl, Br, I); a family of Li-ion conducting ternary halides

Flores-Gonzalez, N. , Minafra, N., Dewald, G., Reardon, H., Smith, R. I., Adams, S., Gregory, D. H. and Zeier, W. G. (2021) Mechanochemical synthesis and structure of lithium tetrahaloaluminates, LiAlX4 (X = Cl, Br, I); a family of Li-ion conducting ternary halides. ACS Materials Letters , 3(5), pp. 652-657. (doi: 10.1021/acsmaterialslett.1c00055 )

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The role of composition and phase upon the lattice nitrogen reactivity of ternary molybdenum nitrides

Daisley, A. , Costley-Wood, L. and Hargreaves, J. S.J. (2021) The role of composition and phase upon the lattice nitrogen reactivity of ternary molybdenum nitrides. Topics in Catalysis , (doi: 10.1007/s11244-021-01432-1 ) (Early Online Publication)

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Layered perovskites in solar cells: structure, optoelectronic properties, and device design

Sirbu, D., Balogun, F. H., Milot, R. L. and Docampo, P. (2021) Layered perovskites in solar cells: structure, optoelectronic properties, and device design. Advanced Energy Materials , (Accepted for Publication)

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Bottromycins - biosynthesis, synthesis and activity

Franz, L., Kazmaier, U., Truman, A. W. and Koehnke, J. (2021) Bottromycins - biosynthesis, synthesis and activity. Natural Product Reports , (doi: 10.1039/D0NP00097C ) (PMID:33621290) (Early Online Publication)

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A comparison of experimental procedures for the application of infrared spectroscopy to probe the surface morphology of an alumina-supported palladium catalyst

McCullagh, A.M. , Warringham, R. , Morisse, C.G.A. , Gilpin, L.F. , Brennan, C., Mitchell, C.J. and Lennon, D. (2021) A comparison of experimental procedures for the application of infrared spectroscopy to probe the surface morphology of an alumina-supported palladium catalyst. Topics in Catalysis , (doi: 10.1007/s11244-021-01435-y ) (Early Online Publication)

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Crystal structure, IR, Raman and UV-Vis studies of [Co(H2P2O7)2(H2O)2][CH3)3C-NH3)]2 2H2O

Alaoui Tahiri, A., El Bali, B., Lachkar, M., Wilson, C. , Bauer, D. and Haisch, C. (2021) Crystal structure, IR, Raman and UV-Vis studies of [Co(H2P2O7)2(H2O)2][CH3)3C-NH3)]2 2H2O. Inorganic Chemistry Communications , 128, 108541. (doi: 10.1016/j.inoche.2021.108541 )

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Application of nanoscale metal-organic frameworks as imaging agents in biology and medicine

Demir Duman, F. and Forgan, R. S. (2021) Application of nanoscale metal-organic frameworks as imaging agents in biology and medicine. Journal of Materials Chemistry B , 9(16), pp. 3423-3449. (doi: 10.1039/D1TB00358E )

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