Dr Jennifer Lees

Senior Clinical Research Fellow/ Honorary Consultant (Cardiovascular & Metabolic Health)

telephone: 0141 330 8015
email: Jennifer.Lees@glasgow.ac.uk

BHF Glasgow Cardiovascular Research Centre, 126 University Avenue, Glasgow, G12 8TA

Biography

Dr Jennifer Lees, MA (Cantab) MBChB MRCP(Neph) PhD, is a Senior Clinical Research Fellow and Lead for Data Science (School of Cardiovascular and Metabolic Health, University of Glasgow) and Honorary Consultant Nephrologist (NHS Greater Glasgow and Clyde). She graduated from the Universities of Cambridge and Edinburgh then moved to Glasgow to train in renal and general internal medicine in 2013. During her PhD, she designed and led the ViKTORIES trial (ISRCTN22012044; funded by (Kidney Research UK) testing vitamin K supplementation to treat vascular stiffness and calcification in kidney transplant recipients. She was a co-investigator on the K4Kidneys vitamin K trial in people with CKD 3b/4 (ISRCTN21444964; funded by (British Heart Foundation). Her post-doctoral lectureship was funded by the Chief Scientist Office (Scotland).

In 2022, Dr Lees won two prestigious annual awards for significant contributions to renal research as a junior investigator: the UK Kidney Association Raine Award and European Renal Association (ERA) Eberhard Ritz Award for Clinical Science and was recognised as a “Rising Star” by the International Society of Nephrology. Dr Lees is current Visual Abstracts and Biomarkers/Formula Editor for Nephrology Dialysis Transplantation, ERA mentor, previous co-chair of the ERA Journal Club and current member of the UK Renal Health Data Network, UK Kidney Association Renal Trials Network, Cardio-Renal Clinical Study Group and eGFR Working Group.

Research interests

Dr Lees works within the Renal Research Team and is a member of the Cardio-Nephro-Oncology (CaNOn) Research Group. Dr Lees is interested in: using data science and clinical trials to understand and improve the long-term risks associated with chronic kidney disease (CKD), particularly cardiovascular disease and cancer; use of cystatin C for risk-stratification of adverse outcomes; sex disparities in the care and outcomes of people with CKD.

Publications

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Jump to: 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2015 | 2013 | 2012 | 2011 | 2008 | 2007

Number of items: 51.

2023

Lees, J. S. and Mark, P. B. (2023) GFR slope as a surrogate marker for future kidney failure. Nature Reviews Nephrology, 19, pp. 625-626. (doi: 10.1038/s41581-023-00748-3) (PMID:37495682)

Lees, J. S. , De La Mata, N. L., Sullivan, M. K. , Wyld, M. L., Rosales, B. M., Cutting, R., Hedley, J. A., Rutherford, E., Mark, P. B. and Webster, A. C. (2023) Sex differences in associations between creatinine and cystatin C-based kidney function measures with stroke and major bleeding. European Stroke Journal, 8(3), pp. 756-768. (doi: 10.1177/23969873231173282)

Elyan, B. M.P., Rankin, S., Jones, R. , Lang, N. N. , Mark, P. B. and Lees, J. S. (2023) Kidney disease patient representation in trials of combination therapy with VEGF-signaling pathway inhibitors and immune checkpoint inhibitors: a systematic review. Kidney Medicine, 5(7), 100672. (doi: 10.1016/j.xkme.2023.100672) (PMID:37492115) (PMCID:PMC10363559)

Grant, C. H. , Salim, E., Lees, J. S. and Stevens, K. I. (2023) Deprivation and chronic kidney disease—a review of the evidence. Clinical Kidney Journal, 16(7), pp. 1081-1091. (doi: 10.1093/ckj/sfad028) (PMID:37398697) (PMCID:PMC10310512)

Lees, J. S. , Dobbin, S. J.H. , Elyan, B. M.P., Gilmour, D. F., Tomlinson, L. P., Lang, N. N. and Mark, P. B. (2023) A systematic review and meta-analysis of the effect of intravitreal VEGF inhibitors on cardiorenal outcomes. Nephrology Dialysis Transplantation, 38(7), pp. 1666-1681. (doi: 10.1093/ndt/gfac305) (PMID:36318455) (PMCID:PMC10310520)

Mayne, K. J., Sullivan, M. K. and Lees, J. S. (2023) Sex and gender differences in the management of chronic kidney disease and hypertension. Journal of Human Hypertension, (doi: 10.1038/s41371-023-00843-9) (Early Online Publication)

Stevens, K. I. and Lees, J. S. (2023) Measure and risk: cystatin C, creatinine and controversy in CKD. Nephrology Dialysis Transplantation, (doi: 10.1093/ndt/gfad113) (PMID:37245066) (Early Online Publication)

Lees, J. S. , Elyan, B. M.P., Hermann, S. M., Lang, N. N. , Jones, R. J. and Mark, P. B. (2023) The ‘other’ big complication: how chronic kidney disease impacts on cancer risks and outcomes. Nephrology Dialysis Transplantation, 38(5), pp. 1071-1079. (doi: 10.1093/ndt/gfac011) (PMID:35090037) (PMCID:PMC10157781)

Mayne, K. J., Lees, J. S. and Herrington, W. G. (2023) Bioimpedance in CKD: an untapped resource? Nephrology Dialysis Transplantation, 38(3), pp. 583-585. (doi: 10.1093/ndt/gfac275) (PMID:36260361) (PMCID:PMC9976732)

Mayne, K. J., Lees, J. S. and Mark, P. B. (2023) Cardiovascular complications of chronic kidney disease. Medicine, 51(3), pp. 190-195. (doi: 10.1016/j.mpmed.2022.12.008)

Mayne, K. J., Lees, J. S. , Rutherford, E., Thomson, P. C., Traynor, J. P., Dey, V. , Lang, N. N. and Mark, P. B. (2023) Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios: associations with mortality in a haemodialysis cohort. Clinical Kidney Journal, 16(3), pp. 512-520. (doi: 10.1093/ckj/sfac248) (PMID:36865003) (PMCID:PMC9972818)

Chen, D. C., Lees, J. S. , Lu, K., Scherzer, R., Rutherford, E., Mark, P. B. , Kanaya, A. M., Shlipak, M. G. and Estrella, M. M. (2023) Differential associations of cystatin C versus creatinine‐based kidney function with risks of cardiovascular event and mortality among South Asian individuals in the UK Biobank. Journal of the American Heart Association, 12(3), e027079. (doi: 10.1161/JAHA.122.027079) (PMID:36695320) (PMCID:PMC9973614)

Sullivan, M. K. et al. (2023) Potential impact of NICE guidelines on referrals from primary care to nephrology: a primary care database and prospective research study. British Journal of General Practice, 73(727), e141-e147. (doi: 10.3399/BJGP.2022.0145) (PMID:36376072) (PMCID:PMC9678375)

Stevens, K. I., Graham-Brown, M. and Lees, J. S. (2023) Let's get physical: considering and overcoming the barriers to physical activity in CKD. Nephrology Dialysis Transplantation, (doi: 10.1093/ndt/gfad002) (PMID:36662119) (Early Online Publication)

2022

Lithgow, H. et al. (2022) Protocol for a randomised controlled trial to investigate the effects of vitamin K2 on recovery from muscle-damaging resistance exercise in young and older adults—the TAKEOVER study. Trials, 23, 1026. (doi: 10.1186/s13063-022-06937-y) (PMID:36539791) (PMCID:PMC9764575)

Lees, J. S. and Shlipak, M. G. (2022) Age-adapted eGFR thresholds underestimate the risks beyond kidney failure associated with CKD in older populations. Journal of the American Geriatrics Society, 70(12), pp. 3660-3664. (doi: 10.1111/jgs.18046) (PMID:36151987)

Mayne, K. J., Shemilt, R., Keane, D. F., Lees, J. S. , Mark, P. B. and Herrington, W. G. (2022) Bioimpedance indices of fluid overload and cardiorenal outcomes in heart failure and chronic kidney disease: a systematic review. Journal of Cardiac Failure, 28(11), pp. 1628-1641. (doi: 10.1016/j.cardfail.2022.08.005) (PMID:36038013)

Lees, J. S. , Rutherford, E., Stevens, K. I., Chen, D. C., Scherzer, R., Estrella, M. M., Sullivan, M. K. , Ebert, N., Mark, P. B. and Shlipak, M. G. (2022) Assessment of Cystatin C level for risk stratification in adults with chronic kidney disease. JAMA Network Open, 5(10), e2238300. (doi: 10.1001/jamanetworkopen.2022.38300) (PMID:36282503) (PMCID:PMC9597396)

Lees, J. S. and Mark, P. B. (2022) Insights into vitamin K metabolism in chronic kidney disease: more complicated than kale deficiency. Kidney International, 101(2), pp. 216-219. (doi: 10.1016/j.kint.2021.11.022) (PMID:35065688)

Sullivan, M. K. et al. (2022) Acute kidney injury in patients hospitalised with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study. Nephrology Dialysis Transplantation, 37(2), pp. 271-284. (doi: 10.1093/ndt/gfab303) (PMID:34661677) (PMCID:PMC8788218)

Lees, J. S. and Mark, P. B. (2022) Vitamin K supplementation and vascular health after kidney transplantation: authors' response. American Journal of Transplantation, 22(1), pp. 320-321. (doi: 10.1111/ajt.16769) (PMID:34291553)

Lees, J. S. et al. (2022) Effect of age, sex, and morbidity count on trial attrition: meta-analysis of individual participant level data from phase 3/4 industry funded clinical trials. BMJ Medicine, 1(1), e000217. (doi: 10.1136/bmjmed-2022-000217) (PMID:36936559) (PMCID:PMC9978693)

2021

Rankin, A. J. et al. (2021) Myocardial changes on 3T cardiovascular magnetic resonance imaging in response to haemodialysis with fluid removal. Journal of Cardiovascular Magnetic Resonance, 23, 125. (doi: 10.1186/s12968-021-00822-4) (PMCID:PMC8580743)

Sullivan, M. K. et al. (2021) Multimorbidity and the risk of major adverse kidney events: findings from the UK Biobank cohort. Clinical Kidney Journal, 14(11), pp. 2409-2419. (doi: 10.1093/ckj/sfab079) (PMCID:PMC8573008)

Lees, J. S. et al. (2021) The ViKTORIES trial: a randomised, double-blind, placebo-controlled trial of vitamin K supplementation to improve vascular health in kidney transplant recipients. American Journal of Transplantation, 21(10), pp. 3356-3368. (doi: 10.1111/ajt.16566) (PMID:33742520)

Rankin, A. J. et al. (2021) Global longitudinal strain by feature tracking cardiovascular MRI predicts mortality in patients with end stage kidney disease. Clinical Kidney Journal, 14(10), pp. 2187-2196. (doi: 10.1093/ckj/sfab020)

Lees, J. S. et al. (2021) Kidney function and cancer risk: an analysis using creatinine and cystatin C in a cohort study. EClinicalMedicine, 38, 101030. (doi: 10.1016/j.eclinm.2021.101030) (PMID:34505030)

Lees, J. S. , Mark, P. B. and Witham, M. D. (2021) Vitamin K and vascular calcification. Current Opinion in Nephrology and Hypertension, 30(4), pp. 430-436. (doi: 10.1097/MNH.0000000000000712) (PMID:33871429)

Li, K. K. et al. (2021) Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units - a high risk community-hospital interface. Journal of Infection, 83(1), pp. 96-103. (doi: 10.1016/j.jinf.2021.04.020) (PMID:33895226) (PMCID:PMC8061788)

Edy, E. et al. (2021) Cardiovascular magnetic resonance for the detection of descending thoracic aorta calcification in patients with end-stage renal disease. Journal of Cardiovascular Magnetic Resonance, 23(1), 85. (doi: 10.1186/s12968-021-00769-6) (PMID:34162405) (PMCID:PMC8223384)

Lees, J. S. and Mark, P. B. (2021) Fruit for thought: lifestyle interventions to reduce the risk of future chronic kidney disease. Nephrology Dialysis Transplantation, 36(6), pp. 963-965. (doi: 10.1093/ndt/gfaa266) (PMID:33313844)

O’Sullivan, E. D., Lees, J. S. , Howie, K. L., Pugh, D., Gillis, K. A. , Traynor, J. P., Macintyre, I. and Mark, P. B. (2021) Prolonged SARS-CoV-2 viral shedding in patients with chronic kidney disease. Nephrology, 26(4), pp. 328-332. (doi: 10.1111/nep.13844) (PMID:33368892)

Lees, J. S. and Mark, P. B. (2021) Cystatin C to predict renal disease and cardiovascular risk. Nephrology Dialysis Transplantation, 36(1), pp. 39-41. (doi: 10.1093/ndt/gfaa152) (PMID:32514520)

2020

Witham, M. D. et al. (2020) Vitamin K supplementation to improve vascular stiffness in chronic kidney disease: the K4Kidneys randomised controlled trial. Journal of the American Society of Nephrology, 31(10), pp. 2434-2445. (doi: 10.1681/ASN.2020020225) (PMID:32817311)

Lees, J. S. , Mangion, K., Rutherford, E., Witham, M. D., Woodward, R., Roditi, G., Hopkins, T., Brooksbank, K., Jardine, A. and Mark, P. B. (2020) Vitamin K for kidney transplant organ recipients: investigating vEssel stiffness (ViKTORIES): study rationale and protocol of a randomised controlled trial. Open Heart, 7, e001070. (doi: 10.1136/openhrt-2019-001070) (PMID:32675297) (PMCID:PMC7368482)

2019

Grant, C. H. , Gillis, K. A. , Lees, J. S. , Traynor, J. P., Mark, P. B. and Stevens, K. I. (2019) Proton pump inhibitor use and progression to major adverse renal events: a competing risk analysis. QJM: An International Journal of Medicine, 112(11), pp. 835-840. (doi: 10.1093/qjmed/hcz166) (PMID:31251364)

Lees, J. S. et al. (2019) Glomerular filtration rate by differing measures, albuminuria and prediction of cardiovascular disease, mortality and end-stage kidney disease. Nature Medicine, 25, pp. 1753-1760. (doi: 10.1038/s41591-019-0627-8) (PMID:31700174) (PMCID:PMC6858876)

Elyan, B. M.P., Lees, J. S. , Gillis, K. A. , Mackinnon, B., Fox, J. G., Geddes, C. C. and McQuarrie, E. P. (2019) Obesity is not associated with progression to end stage renal disease in patients with biopsy-proven glomerular diseases. BMC Nephrology, 20, 237. (doi: 10.1186/s12882-019-1434-7) (PMID:31266462) (PMCID:PMC6604373)

Lees, J.S. , Chapman, F.A., Witham, M.D., Jardine, A.G. and Mark, P.B. (2019) Vitamin K status, supplementation and vascular disease: a systematic review and meta-analysis. Heart, 105(12), pp. 938-945. (doi: 10.1136/heartjnl-2018-313955) (PMID:30514729)

Gillis, K. A. , Lees, J. S. , Ralston, M. R., Glen, J. A., Stevenson, K. S., McManus, S. K., Geddes, C. C., Clancy, M., Traynor, J. P. and Mark, P. B. (2019) Interaction between socioeconomic deprivation and likelihood of pre‐emptive transplantation: influence of competing risks and referral characteristics – a retrospective study. Transplant International, 32(2), pp. 153-162. (doi: 10.1111/tri.13336) (PMID:30152890)

Lees, J.S. , Findlay, M.D., Mark, P.B. and Geddes, C.C. (2019) The impact of coronary angiography on renal transplant function. QJM: An International Journal of Medicine, 112(1), pp. 23-27. (doi: 10.1093/qjmed/hcy216) (PMID:30295913)

2018

Lees, J. S. , McQuarrie, E. P. and Mackinnon, B. (2018) Renal biopsy: it is time for pragmatism and consensus. Clinical Kidney Journal, 11(5), pp. 605-609. (doi: 10.1093/ckj/sfy075) (PMID:30289128) (PMCID:PMC6165764)

Stoumpos, S., Lees, J. , Welsh, P. , Hund, M., Geddes, C. C., Nelson, S. M. and Mark, P. B. (2018) The utility of anti-Müllerian hormone in women with chronic kidney disease, on haemodialysis and after kidney transplantation. Reproductive BioMedicine Online, 36(2), pp. 219-226. (doi: 10.1016/j.rbmo.2017.11.003) (PMID:29233504)

2017

Lees, J. S. , McQuarrie, E. P., Mordi, N., Geddes, C. C., Fox, J. G. and Mackinnon, B. (2017) Risk factors for bleeding complications after nephrologist-performed native renal biopsy. Clinical Kidney Journal, 10(4), pp. 573-577. (doi: 10.1093/ckj/sfx012) (PMID:28852497) (PMCID:PMC5570080)

2015

Lees, J. S. , Mark, P. B. and Jardine, A. G. (2015) Cardiovascular complications of chronic kidney disease. Medicine, 43(8), pp. 469-473. (doi: 10.1016/j.mpmed.2015.05.009)

2013

Altman, D. G., Antonic, A., Sena, E. S., Lees, J. S. , Wills, T. E., Skeers, P., Batchelor, P. E., Macleod, M. R. and Howells, D. W. (2013) Stem cell transplantation in traumatic spinal cord injury: a systematic review and meta-analysis of animal studies. PLoS Biology, 11(12), e1001738. (doi: 10.1371/journal.pbio.1001738) (PMID:24358022) (PMCID:PMC3866091)

Lees, J.S. , Church, N., Langdale-Brown, B., Bellamy, C., Gibson, P. and Watson, S. (2013) IgG4-related disease: a novel, important but easily missed condition. Journal of the Royal College of Physicians of Edinburgh, 43(2), pp. 126-133. (doi: 10.4997/JRCPE.2013.208) (PMID:23734354)

2012

Lees, J. S. , Sena, E. S., Egan, K. J., Antonic, A., Koblar, S. A., Howells, D. W. and Macleod, M. R. (2012) Stem cell‐based therapy for experimental stroke: a systematic review and meta‐analysis. International Journal of Stroke, 7(7), pp. 582-588. (doi: 10.1111/j.1747-4949.2012.00797.x) (PMID:22687044)

2011

Lees, J.S. , Mishra, N.K., Saini, M., Lyden, P.D. and Shuaib, A. (2011) Low body temperature does not compromise the treatment effect of alteplase. Stroke, 42(9), pp. 2618-2621. (doi: 10.1161/STROKEAHA.110.611210)

2008

Quinn, T.J. , Dawson, J. , Lees, J.S. , Chang, T.P., Walters, M.R. and Lees, K.R. (2008) Time spent at home poststroke: “home-time” a meaningful and robust outcome measure for stroke trials. Stroke, 39(1), pp. 231-233. (doi: 10.1161/STROKEAHA.107.493320)

2007

Dawson, J. , Lees, J.S. , Chang, T.P., Walters, M.R. , Ali, M. , Davis, S.M., Diener, H.C. and Lees, K.R. (2007) Association between disability measures and healthcare costs after initial treatment for acute stroke. Stroke, 38(6), pp. 1893-1898. (doi: 10.1161/STROKEAHA.106.472381)

This list was generated on Sun Oct 1 19:01:11 2023 BST.

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