School of Cardiovascular & Metabolic Health

Lees, J. S., Fabian, J., Shlipak, M. G. (2024) Cystatin C should be routinely available for estimating kidney function. Current Opinion in Nephrology and Hypertension, 33, pp. 337-343. (doi: 10.1097/MNH.0000000000000980)

Lang, N., Rankin, S., Elyan, B., Jones, R., Venugopal, B., Mark, P. B., Lees, J., Petrie, M., Lang, N. (2024) Cardiovascular eligibility criteria and adverse event reporting in combined immune checkpoint and VEGF inhibitors trials. JACC: CardioOncology, 6, pp. 267-279. (doi: 10.1016/j.jaccao.2023.12.010)

Mayne, K. J., Hanlon, P., Lees, J. (2024) Detecting and managing the patient with CKD in primary care: a review of the latest guidelines. Diabetes, Obesity and Metabolism,

Chen, D. C., Lu, K., Scherzer, R., Lees, J. S., Rutherford, E., Mark, P. B., Potok, O. A., Rifkin, D. E., Ix, J. H., Shlipak, M. G., Estrella, M. M. (2024) Cystatin C- and creatinine-based estimated GFR differences: prevalence and predictors in the UK Biobank. Kidney Medicine, 6, (doi: 10.1016/j.xkme.2024.100796)

Shemilt, R., Sullivan, M.K., Hanlon, P., Jani, B., De La Mata, N., Rosales, B., Elyan, B.M.P., Hedley, J.A., Cutting, R.B., Wyld, M., McAllister, D.A., Webster, A.C., Mark, P.B., Lees, J.S. (2024) Sex differences in cancer outcomes across the range of eGFR. Nephrology Dialysis Transplantation, (doi: 10.1093/ndt/gfae059)

Mayne, K. J. et al. (2023) Effects of empagliflozin on fluid overload, weight and blood pressure in chronic kidney disease. Journal of the American Society of Nephrology, (doi: 10.1681/ASN.0000000000000271)

Jani, B. D., Sullivan, M. K., Hanlon, P., Nicholl, B. I., Lees, J. S., Brown, L., MacDonald, S., Mark, P. B., Mair, F. S., Sullivan, F. M. (2023) Personalised lung cancer risk stratification and lung cancer screening: do general practice electronic medical records have a role? British Journal of Cancer, (doi: 10.1038/s41416-023-02467-9)

Lees, J. S., Mark, P. B. (2023) GFR slope as a surrogate marker for future kidney failure. Nature Reviews Nephrology, 19, pp. 625-626. (doi: 10.1038/s41581-023-00748-3)

Lees, J. S., De La Mata, N. L., Sullivan, M. K., Wyld, M. L., Rosales, B. M., Cutting, R., Hedley, J. A., Rutherford, E., Mark, P. B., Webster, A. C. (2023) Sex differences in associations between creatinine and cystatin C-based kidney function measures with stroke and major bleeding. European Stroke Journal, 8, pp. 756-768. (doi: 10.1177/23969873231173282)

Lees, J. S., Dobbin, S. J.H., Elyan, B. M.P., Gilmour, D. F., Tomlinson, L. P., Lang, N. N., Mark, P. B. (2023) A systematic review and meta-analysis of the effect of intravitreal VEGF inhibitors on cardiorenal outcomes. Nephrology Dialysis Transplantation, 38, pp. 1666-1681. (doi: 10.1093/ndt/gfac305)

Grant, C. H., Salim, E., Lees, J. S., Stevens, K. I. (2023) Deprivation and chronic kidney disease—a review of the evidence. Clinical Kidney Journal, 16, pp. 1081-1091. (doi: 10.1093/ckj/sfad028)

Elyan, B. M.P., Rankin, S., Jones, R., Lang, N. N., Mark, P. B., Lees, J. S. (2023) Kidney disease patient representation in trials of combination therapy with VEGF-signaling pathway inhibitors and immune checkpoint inhibitors: a systematic review. Kidney Medicine, 5, (doi: 10.1016/j.xkme.2023.100672)

Mayne, K. J., Sullivan, M. K., Lees, J. S. (2023) Sex and gender differences in the management of chronic kidney disease and hypertension. Journal of Human Hypertension, (doi: 10.1038/s41371-023-00843-9)

Stevens, K. I., Graham-Brown, M., Lees, J. S. (2023) Let's get physical: considering and overcoming the barriers to physical activity in CKD. Nephrology Dialysis Transplantation, 38, pp. 1405-1407. (doi: 10.1093/ndt/gfad002)

Stevens, K. I., Lees, J. S. (2023) Measure and risk: cystatin C, creatinine and controversy in CKD. Nephrology Dialysis Transplantation, (doi: 10.1093/ndt/gfad113)

Lees, J. S., Elyan, B. M.P., Hermann, S. M., Lang, N. N., Jones, R. J., Mark, P. B. (2023) The ‘other’ big complication: how chronic kidney disease impacts on cancer risks and outcomes. Nephrology Dialysis Transplantation, 38, pp. 1071-1079. (doi: 10.1093/ndt/gfac011)

Mayne, K. J., Lees, J. S., Herrington, W. G. (2023) Bioimpedance in CKD: an untapped resource? Nephrology Dialysis Transplantation, 38, pp. 583-585. (doi: 10.1093/ndt/gfac275)

Mayne, K. J., Lees, J. S., Mark, P. B. (2023) Cardiovascular complications of chronic kidney disease. Medicine, 51, pp. 190-195. (doi: 10.1016/j.mpmed.2022.12.008)

Mayne, K. J., Lees, J. S., Rutherford, E., Thomson, P. C., Traynor, J. P., Dey, V., Lang, N. N., Mark, P. B. (2023) Neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios: associations with mortality in a haemodialysis cohort. Clinical Kidney Journal, 16, pp. 512-520. (doi: 10.1093/ckj/sfac248)

Chen, D. C., Lees, J. S., Lu, K., Scherzer, R., Rutherford, E., Mark, P. B., Kanaya, A. M., Shlipak, M. G., Estrella, M. M. (2023) Differential associations of cystatin C versus creatinine‐based kidney function with risks of cardiovascular event and mortality among South Asian individuals in the UK Biobank. Journal of the American Heart Association, 12, (doi: 10.1161/JAHA.122.027079)

Sullivan, M. K., Jani, B. D., Rutherford, E., Welsh, P., McConnachie, A., Major, R. W., McAllister, D., Nitsch, D., Mair, F. S., Mark, P. B., Lees, J. S. (2023) Potential impact of NICE guidelines on referrals from primary care to nephrology: a primary care database and prospective research study. British Journal of General Practice, 73, pp. e141-e147. (doi: 10.3399/BJGP.2022.0145)

Lithgow, H., Johnston, L., Ho, F. K., Celis-Morales, C., Cobley, J., Raastad, T., Hunter, A. M., Lees, J. S., Mark, P. B., Quinn, T. J., Gray, S. R. (2022) Protocol for a randomised controlled trial to investigate the effects of vitamin K2 on recovery from muscle-damaging resistance exercise in young and older adults—the TAKEOVER study. Trials, 23, (doi: 10.1186/s13063-022-06937-y)

Lees, J. S., Shlipak, M. G. (2022) Age-adapted eGFR thresholds underestimate the risks beyond kidney failure associated with CKD in older populations. Journal of the American Geriatrics Society, 70, pp. 3660-3664. (doi: 10.1111/jgs.18046)

Mayne, K. J., Shemilt, R., Keane, D. F., Lees, J. S., Mark, P. B., Herrington, W. G. (2022) Bioimpedance indices of fluid overload and cardiorenal outcomes in heart failure and chronic kidney disease: a systematic review. Journal of Cardiac Failure, 28, pp. 1628-1641. (doi: 10.1016/j.cardfail.2022.08.005)

Lees, J. S., Rutherford, E., Stevens, K. I., Chen, D. C., Scherzer, R., Estrella, M. M., Sullivan, M. K., Ebert, N., Mark, P. B., Shlipak, M. G. (2022) Assessment of Cystatin C level for risk stratification in adults with chronic kidney disease. JAMA Network Open, 5, (doi: 10.1001/jamanetworkopen.2022.38300)

Sullivan, M. K., Lees, J. S., Drake, T. M., Docherty, A. B., Oates, G., Hardwick, H. E., Russell, C. D., Merson, L., Dunning, J., Nguyen-Van-Tam, J. S., Openshaw, P., Harrison, E. M., Baillie, J. K., ISARIC4C Investigators, , Semple, M. G., Ho, A., Mark, P. B., Scott, J. T., Davis, C. (2022) Acute kidney injury in patients hospitalised with COVID-19 from the ISARIC WHO CCP-UK Study: a prospective, multicentre cohort study. Nephrology Dialysis Transplantation, 37, pp. 271-284. (doi: 10.1093/ndt/gfab303)

Lees, J. S., Mark, P. B. (2022) Insights into vitamin K metabolism in chronic kidney disease: more complicated than kale deficiency. Kidney International, 101, pp. 216-219. (doi: 10.1016/j.kint.2021.11.022)

Lees, J. S., Mark, P. B. (2022) Vitamin K supplementation and vascular health after kidney transplantation: authors' response. American Journal of Transplantation, 22, pp. 320-321. (doi: 10.1111/ajt.16769)

Lees, J. S., Hanlon, P., Butterly, E. W., Wild, S. H., Mair, F. S., Taylor, R. S., Guthrie, B., Gillies, K., Dias, S., Welton, N. J., McAllister, D. A. (2022) Effect of age, sex, and morbidity count on trial attrition: meta-analysis of individual participant level data from phase 3/4 industry funded clinical trials. BMJ Medicine, 1, (doi: 10.1136/bmjmed-2022-000217)

Rankin, A. J., Mangion, K., Lees, J. S., Rutherford, E., Gillis, K. A., Edy, E., Dymock, L., Treibel, T. A., Radjenovic, A., Patel, R. K., Berry, C., Roditi, G., Mark, P. B. (2021) Myocardial changes on 3T cardiovascular magnetic resonance imaging in response to haemodialysis with fluid removal. Journal of Cardiovascular Magnetic Resonance, 23, (doi: 10.1186/s12968-021-00822-4)

Sullivan, M. K., Jani, B. D., Lees, J. S., Welsh, C. E., McConnachie, A., Stanley, B., Welsh, P., Nicholl, B. I., Lyall, D. M., Carrero, J.-J., Nitsch, D., Sattar, N., Mair, F. S., Mark, P. B. (2021) Multimorbidity and the risk of major adverse kidney events: findings from the UK Biobank cohort. Clinical Kidney Journal, 14, pp. 2409-2419. (doi: 10.1093/ckj/sfab079)

Rankin, A. J., Zhu, L., Mangion, K., Rutherford, E., Gillis, K. A., Lees, J. S., Woodward, R., Patel, R. K., Berry, C., Roditi, G., Mark, P. B. (2021) Global longitudinal strain by feature tracking cardiovascular MRI predicts mortality in patients with end stage kidney disease. Clinical Kidney Journal, 14, pp. 2187-2196. (doi: 10.1093/ckj/sfab020)

Lees, J. S., Rankin, A. J., Gillis, K. A., Zhu, L. Y., Mangion, K., Rutherford, E., Roditi, G. H., Witham, M. D., Chantler, D., Panarelli, M., Jardine, A. G., Mark, P. B. (2021) The ViKTORIES trial: a randomised, double-blind, placebo-controlled trial of vitamin K supplementation to improve vascular health in kidney transplant recipients. American Journal of Transplantation, 21, pp. 3356-3368. (doi: 10.1111/ajt.16566)

Lees, J. S., Ho, F., Parra -Soto, S., Celis-Morales, C., Welsh, P., Sullivan, M. K., Jani, B. D., Sattar, N., Lang, N. N., Pell, J. P., Webster, A. C., Mark, P. B. (2021) Kidney function and cancer risk: an analysis using creatinine and cystatin C in a cohort study. EClinicalMedicine, 38, (doi: 10.1016/j.eclinm.2021.101030)

Li, K. K. et al. (2021) Genetic epidemiology of SARS-CoV-2 transmission in renal dialysis units - a high risk community-hospital interface. Journal of Infection, 83, pp. 96-103. (doi: 10.1016/j.jinf.2021.04.020)

Lees, J. S., Mark, P. B., Witham, M. D. (2021) Vitamin K and vascular calcification. Current Opinion in Nephrology and Hypertension, 30, pp. 430-436. (doi: 10.1097/MNH.0000000000000712)

Edy, E., Rankin, A. J., Lees, J. S., Hall Barrientos, P., Woodward, R., Stoumpos, S., Koktzoglou, I., Edelman, R. R., Radjenovic, A., Mark, P. B., Roditi, G. H. (2021) Cardiovascular magnetic resonance for the detection of descending thoracic aorta calcification in patients with end-stage renal disease. Journal of Cardiovascular Magnetic Resonance, 23, (doi: 10.1186/s12968-021-00769-6)

Lees, J. S., Mark, P. B. (2021) Fruit for thought: lifestyle interventions to reduce the risk of future chronic kidney disease. Nephrology Dialysis Transplantation, 36, pp. 963-965. (doi: 10.1093/ndt/gfaa266)

O’Sullivan, E. D., Lees, J. S., Howie, K. L., Pugh, D., Gillis, K. A., Traynor, J. P., Macintyre, I., Mark, P. B. (2021) Prolonged SARS-CoV-2 viral shedding in patients with chronic kidney disease. Nephrology, 26, pp. 328-332. (doi: 10.1111/nep.13844)

Lees, J. S., Mark, P. B. (2021) Cystatin C to predict renal disease and cardiovascular risk. Nephrology Dialysis Transplantation, 36, pp. 39-41. (doi: 10.1093/ndt/gfaa152)

Witham, M. D., Lees, J. S., White, M., Band, M., Bell, S., Chantler, D. J., Ford, I., Fulton, R. L., Kennedy, G., Littleford, R. C., McCrea, I. V., McGlynn, D., Panarelli, M., Ralston, M. R., Rutherford, E., Severn, A., Thomson, N., Traynor, J. P., Struthers, A. D., Wetherall, K., Mark, P. B. (2020) Vitamin K supplementation to improve vascular stiffness in chronic kidney disease: the K4Kidneys randomised controlled trial. Journal of the American Society of Nephrology, 31, pp. 2434-2445. (doi: 10.1681/ASN.2020020225)

Lees, J. S., Mangion, K., Rutherford, E., Witham, M. D., Woodward, R., Roditi, G., Hopkins, T., Brooksbank, K., Jardine, A., Mark, P. B. (2020) Vitamin K for kidney transplant organ recipients: investigating vEssel stiffness (ViKTORIES): study rationale and protocol of a randomised controlled trial. Open Heart, 7, (doi: 10.1136/openhrt-2019-001070)

Lees, J. S., Welsh, C. E., Celis-Morales, C. A., Mackay, D., Lewsey, J., Gray, S. R., Lyall, D. M., Cleland, J. G., Gill, J. M.R., Jhund, P. S., Pell, J., Sattar, N., Welsh, P., Mark, P. B. (2019) Glomerular filtration rate by differing measures, albuminuria and prediction of cardiovascular disease, mortality and end-stage kidney disease. Nature Medicine, 25, pp. 1753-1760. (doi: 10.1038/s41591-019-0627-8)

Grant, C. H., Gillis, K. A., Lees, J. S., Traynor, J. P., Mark, P. B., Stevens, K. I. (2019) Proton pump inhibitor use and progression to major adverse renal events: a competing risk analysis. QJM: An International Journal of Medicine, 112, pp. 835-840. (doi: 10.1093/qjmed/hcz166)

Elyan, B. M.P., Lees, J. S., Gillis, K. A., Mackinnon, B., Fox, J. G., Geddes, C. C., McQuarrie, E. P. (2019) Obesity is not associated with progression to end stage renal disease in patients with biopsy-proven glomerular diseases. BMC Nephrology, 20, (doi: 10.1186/s12882-019-1434-7)

Lees, J.S., Chapman, F.A., Witham, M.D., Jardine, A.G., Mark, P.B. (2019) Vitamin K status, supplementation and vascular disease: a systematic review and meta-analysis. Heart, 105, pp. 938-945. (doi: 10.1136/heartjnl-2018-313955)

Gillis, K. A., Lees, J. S., Ralston, M. R., Glen, J. A., Stevenson, K. S., McManus, S. K., Geddes, C. C., Clancy, M., Traynor, J. P., Mark, P. B. (2019) Interaction between socioeconomic deprivation and likelihood of pre‐emptive transplantation: influence of competing risks and referral characteristics – a retrospective study. Transplant International, 32, pp. 153-162. (doi: 10.1111/tri.13336)

Lees, J.S., Findlay, M.D., Mark, P.B., Geddes, C.C. (2019) The impact of coronary angiography on renal transplant function. QJM: An International Journal of Medicine, 112, pp. 23-27. (doi: 10.1093/qjmed/hcy216)

Lees, J. S., McQuarrie, E. P., Mackinnon, B. (2018) Renal biopsy: it is time for pragmatism and consensus. Clinical Kidney Journal, 11, pp. 605-609. (doi: 10.1093/ckj/sfy075)

Stoumpos, S., Lees, J., Welsh, P., Hund, M., Geddes, C. C., Nelson, S. M., Mark, P. B. (2018) The utility of anti-Müllerian hormone in women with chronic kidney disease, on haemodialysis and after kidney transplantation. Reproductive BioMedicine Online, 36, pp. 219-226. (doi: 10.1016/j.rbmo.2017.11.003)

Lees, J. S., McQuarrie, E. P., Mordi, N., Geddes, C. C., Fox, J. G., Mackinnon, B. (2017) Risk factors for bleeding complications after nephrologist-performed native renal biopsy. Clinical Kidney Journal, 10, pp. 573-577. (doi: 10.1093/ckj/sfx012)

Lees, J. S., Mark, P. B., Jardine, A. G. (2015) Cardiovascular complications of chronic kidney disease. Medicine, 43, pp. 469-473. (doi: 10.1016/j.mpmed.2015.05.009)

Lees, J.S., Church, N., Langdale-Brown, B., Bellamy, C., Gibson, P., Watson, S. (2013) IgG4-related disease: a novel, important but easily missed condition. Journal of the Royal College of Physicians of Edinburgh, 43, pp. 126-133. (doi: 10.4997/JRCPE.2013.208)

Altman, D. G., Antonic, A., Sena, E. S., Lees, J. S., Wills, T. E., Skeers, P., Batchelor, P. E., Macleod, M. R., Howells, D. W. (2013) Stem cell transplantation in traumatic spinal cord injury: a systematic review and meta-analysis of animal studies. PLoS Biology, 11, (doi: 10.1371/journal.pbio.1001738)