Ms Holly Leslie
- Affiliate (School of Cancer Sciences)
Publications
2026
Williams, H. L. et al. (2026) Spatial molecular plasticity underpins lethal morphologies in lung adenocarcinoma. Modern Pathology, 39(3), 100960. (doi: 10.1016/j.modpat.2026.100960) (PMID:41521010)
2025
Raven, A. et al. (2025) Hepatic zonation determines tumorigenic potential of mutant β-catenin. Nature, (doi: 10.1038/s41586-025-09733-1) (Early Online Publication)
Ansalone, C. et al. (2025) Spatial profiling of giant cell arteritis tissues reveals immune heterogeneity and potential predictors of glucocorticoid response. Annals of the Rheumatic Diseases, (doi: 10.1016/j.ard.2025.09.009) (PMID:41109780) (Early Online Publication)
2024
O’Rourke, C. J. et al. (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73(3), pp. 496-508. (doi: 10.1136/gutjnl-2023-330748) (PMID:37758326) (PMCID:PMC10894814)
Shamis, Suad Ahmad Khalifa, Savioli, Francesca, Ammar, Aula ORCID: https://orcid.org/0000-0002-0375-062X, Al-Badran, Sara S.F., Hatthakarnkul, Phimmada
ORCID: https://orcid.org/0000-0002-5274-5480, Leslie, Holly
ORCID: https://orcid.org/0000-0001-8898-3600, Mallon, Elizabeth, Jamieson, Nigel B.
ORCID: https://orcid.org/0000-0002-9552-4725, McMillan, Donald C.
ORCID: https://orcid.org/0000-0003-4260-5334 and Edwards, Joanne
ORCID: https://orcid.org/0000-0002-7192-6906
(2024)
Spatial transcriptomic analysis of tumour with high and low CAIX expression in TNBC tissue samples using GeoMx™ RNA assay.
Histology and Histopathology: Cellular and Molecular Biology, 39,
pp. 177-200.
(doi: 10.14670/HH-18-655)
(PMID:37681672)
2023
Pennel, Kathryn, Morrow, Elizabeth, Hatthakarnkul, Phimmada ORCID: https://orcid.org/0000-0002-5274-5480, Leslie, Holly
ORCID: https://orcid.org/0000-0001-8898-3600, Mallon, Elizabeth, Andersen, Ditte, Jamieson, Nigel
ORCID: https://orcid.org/0000-0002-9552-4725, McMillan, Donald
ORCID: https://orcid.org/0000-0003-4260-5334, Roseweir, Antonia
ORCID: https://orcid.org/0000-0001-6158-1564 and Edwards, Joanne
ORCID: https://orcid.org/0000-0002-7192-6906
(2023)
High expression of STAT3 within the tumour-associated stroma predicts poor outcome in breast cancer patients.
Cancer Medicine, 12(12),
pp. 13225-13240.
(doi: 10.1002/cam4.6014)
(PMID:37199043)
(PMCID:PMC10315752)
Sykes, R. A. et al. (2023) Vascular mechanisms of post-COVID-19 conditions: rho-kinase is a novel target for therapy. European Heart Journal: Cardiovascular Pharmacotherapy, 9(4), pp. 371-386. (doi: 10.1093/ehjcvp/pvad025) (PMID:37019821) (PMCID:PMC10236521)
Wood, C. S. et al. (2023) Spatially resolved transcriptomics deconvolutes prognostic histological subgroups in patients with colorectal cancer and synchronous liver metastases. Cancer Research, 83(8), pp. 1329-1344. (doi: 10.1158/0008-5472.CAN-22-2794) (PMID:37057593) (PMCID:PMC10102851)
2022
Fisher, N. C. et al. (2022) Biological misinterpretation of transcriptional signatures in tumour samples can unknowingly undermine mechanistic understanding and faithful alignment with preclinical data. Clinical Cancer Research, 28(18), pp. 4056-4069. (doi: 10.1158/1078-0432.CCR-22-1102) (PMID:35792866) (PMCID:PMC9475248)
Articles
Williams, H. L. et al. (2026) Spatial molecular plasticity underpins lethal morphologies in lung adenocarcinoma. Modern Pathology, 39(3), 100960. (doi: 10.1016/j.modpat.2026.100960) (PMID:41521010)
Raven, A. et al. (2025) Hepatic zonation determines tumorigenic potential of mutant β-catenin. Nature, (doi: 10.1038/s41586-025-09733-1) (Early Online Publication)
Ansalone, C. et al. (2025) Spatial profiling of giant cell arteritis tissues reveals immune heterogeneity and potential predictors of glucocorticoid response. Annals of the Rheumatic Diseases, (doi: 10.1016/j.ard.2025.09.009) (PMID:41109780) (Early Online Publication)
O’Rourke, C. J. et al. (2024) Molecular portraits of patients with intrahepatic cholangiocarcinoma who diverge as rapid progressors or long survivors on chemotherapy. Gut, 73(3), pp. 496-508. (doi: 10.1136/gutjnl-2023-330748) (PMID:37758326) (PMCID:PMC10894814)
Shamis, Suad Ahmad Khalifa, Savioli, Francesca, Ammar, Aula ORCID: https://orcid.org/0000-0002-0375-062X, Al-Badran, Sara S.F., Hatthakarnkul, Phimmada
ORCID: https://orcid.org/0000-0002-5274-5480, Leslie, Holly
ORCID: https://orcid.org/0000-0001-8898-3600, Mallon, Elizabeth, Jamieson, Nigel B.
ORCID: https://orcid.org/0000-0002-9552-4725, McMillan, Donald C.
ORCID: https://orcid.org/0000-0003-4260-5334 and Edwards, Joanne
ORCID: https://orcid.org/0000-0002-7192-6906
(2024)
Spatial transcriptomic analysis of tumour with high and low CAIX expression in TNBC tissue samples using GeoMx™ RNA assay.
Histology and Histopathology: Cellular and Molecular Biology, 39,
pp. 177-200.
(doi: 10.14670/HH-18-655)
(PMID:37681672)
Pennel, Kathryn, Morrow, Elizabeth, Hatthakarnkul, Phimmada ORCID: https://orcid.org/0000-0002-5274-5480, Leslie, Holly
ORCID: https://orcid.org/0000-0001-8898-3600, Mallon, Elizabeth, Andersen, Ditte, Jamieson, Nigel
ORCID: https://orcid.org/0000-0002-9552-4725, McMillan, Donald
ORCID: https://orcid.org/0000-0003-4260-5334, Roseweir, Antonia
ORCID: https://orcid.org/0000-0001-6158-1564 and Edwards, Joanne
ORCID: https://orcid.org/0000-0002-7192-6906
(2023)
High expression of STAT3 within the tumour-associated stroma predicts poor outcome in breast cancer patients.
Cancer Medicine, 12(12),
pp. 13225-13240.
(doi: 10.1002/cam4.6014)
(PMID:37199043)
(PMCID:PMC10315752)
Sykes, R. A. et al. (2023) Vascular mechanisms of post-COVID-19 conditions: rho-kinase is a novel target for therapy. European Heart Journal: Cardiovascular Pharmacotherapy, 9(4), pp. 371-386. (doi: 10.1093/ehjcvp/pvad025) (PMID:37019821) (PMCID:PMC10236521)
Wood, C. S. et al. (2023) Spatially resolved transcriptomics deconvolutes prognostic histological subgroups in patients with colorectal cancer and synchronous liver metastases. Cancer Research, 83(8), pp. 1329-1344. (doi: 10.1158/0008-5472.CAN-22-2794) (PMID:37057593) (PMCID:PMC10102851)
Fisher, N. C. et al. (2022) Biological misinterpretation of transcriptional signatures in tumour samples can unknowingly undermine mechanistic understanding and faithful alignment with preclinical data. Clinical Cancer Research, 28(18), pp. 4056-4069. (doi: 10.1158/1078-0432.CCR-22-1102) (PMID:35792866) (PMCID:PMC9475248)