2025

Boscenco, S. et al. (2025) Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer. Nature Genetics, 57(11), pp. 2705-2714. (doi: 10.1038/s41588-025-02374-0) (PMID:41184543) (PMCID:PMC12597822)

2024

Mahmood, M. et al. (2024) Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma. Nature Cancer, 5(4), pp. 659-672. (doi: 10.1038/s43018-023-00721-w) (PMID:38286828) (PMCID:PMC11056318)

2022

Ganly, I. et al. (2022) Mitonuclear genotype remodels the metabolic and microenvironmental landscape of Hürthle cell carcinoma. Science Advances, 8(25), eabn9699. (doi: 10.1126/sciadv.abn9699) (PMID:35731870) (PMCID:PMC9216518)

2020

Dhayade, Sandeep, Pietzke, Matthias, Wiesheu, Robert, Tait-Mulder, Jacqueline, Athineos, Dimitris, Sumpton, David, Coffelt, Seth ORCID: https://orcid.org/0000-0003-2257-2862, Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X and Vazquez, Alexei ORCID: https://orcid.org/0000-0003-2764-3244 (2020) Impact of formate supplementation on body weight and plasma amino acids. Nutrients, 12(8), 2181. (doi: 10.3390/nu12082181) (PMID:32708052) (PMCID:PMC7469024)

Pietzke, Matthias, Burgos-Barragan, Guillermo, Wit, Niek, Tait-Mulder, Jacqueline, Sumpton, David, Mackay, Gillian M., Patel, Ketan J. and Vazquez, Alexei ORCID: https://orcid.org/0000-0003-2764-3244 (2020) Amino acid dependent formaldehyde metabolism in mammals. Communications Chemistry, 3, 78. (doi: 10.1038/s42004-020-0324-z) (PMID:36703413) (PMCID:PMC9814826)

Oizel, K. et al. (2020) Formate induces a metabolic switch in nucleotide and energy metabolism. Cell Death and Disease, 11(5), 310. (doi: 10.1038/s41419-020-2523-z) (PMID:32366892) (PMCID:PMC7198490)

Michalopoulou, Evdokia, Auciello, Francesca R., Bulusu, Vinay, Strachan, David, Campbell, Andrew D., Tait-Mulder, Jacqueline, Karim, Saadia A., Morton, Jennifer P. ORCID: https://orcid.org/0000-0001-5766-9141, Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010 and Kamphorst, Jurre J. ORCID: https://orcid.org/0000-0002-2042-5474 (2020) Macropinocytosis renders a subset of pancreatic tumor cells resistant to mTOR inhibition. Cell Reports, 30(8), 2729-2742.e4. (doi: 10.1016/j.celrep.2020.01.080) (PMID:32101748) (PMCID:PMC7043007)

2019

Auciello, F. R. et al. (2019) A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression. Cancer Discovery, 9(5), pp. 617-627. (doi: 10.1158/2159-8290.CD-18-1212) (PMID:30837243) (PMCID:PMC6497553)

2018

Port, J. et al. (2018) Colorectal tumors require NUAK1 for protection from oxidative stress. Cancer Discovery, 8(5), pp. 632-647. (doi: 10.1158/2159-8290.CD-17-0533) (PMID:29500295) (PMCID:PMC5935231)

Monteverde, T., Tait-Mulder, J., Hedley, A,, Knight, J.R., Sansom, O.J. ORCID: https://orcid.org/0000-0001-9540-3010 and Murphy, D.J. ORCID: https://orcid.org/0000-0002-5538-5468 (2018) Calcium signalling links MYC to NUAK1. Oncogene, 37(8), pp. 982-992. (doi: 10.1038/onc.2017.394) (PMID:29106388)

Articles

Boscenco, S. et al. (2025) Functionally dominant hotspot mutations of mitochondrial ribosomal RNA genes in cancer. Nature Genetics, 57(11), pp. 2705-2714. (doi: 10.1038/s41588-025-02374-0) (PMID:41184543) (PMCID:PMC12597822)

Mahmood, M. et al. (2024) Mitochondrial DNA mutations drive aerobic glycolysis to enhance checkpoint blockade response in melanoma. Nature Cancer, 5(4), pp. 659-672. (doi: 10.1038/s43018-023-00721-w) (PMID:38286828) (PMCID:PMC11056318)

Ganly, I. et al. (2022) Mitonuclear genotype remodels the metabolic and microenvironmental landscape of Hürthle cell carcinoma. Science Advances, 8(25), eabn9699. (doi: 10.1126/sciadv.abn9699) (PMID:35731870) (PMCID:PMC9216518)

Dhayade, Sandeep, Pietzke, Matthias, Wiesheu, Robert, Tait-Mulder, Jacqueline, Athineos, Dimitris, Sumpton, David, Coffelt, Seth ORCID: https://orcid.org/0000-0003-2257-2862, Blyth, Karen ORCID: https://orcid.org/0000-0002-9304-439X and Vazquez, Alexei ORCID: https://orcid.org/0000-0003-2764-3244 (2020) Impact of formate supplementation on body weight and plasma amino acids. Nutrients, 12(8), 2181. (doi: 10.3390/nu12082181) (PMID:32708052) (PMCID:PMC7469024)

Pietzke, Matthias, Burgos-Barragan, Guillermo, Wit, Niek, Tait-Mulder, Jacqueline, Sumpton, David, Mackay, Gillian M., Patel, Ketan J. and Vazquez, Alexei ORCID: https://orcid.org/0000-0003-2764-3244 (2020) Amino acid dependent formaldehyde metabolism in mammals. Communications Chemistry, 3, 78. (doi: 10.1038/s42004-020-0324-z) (PMID:36703413) (PMCID:PMC9814826)

Oizel, K. et al. (2020) Formate induces a metabolic switch in nucleotide and energy metabolism. Cell Death and Disease, 11(5), 310. (doi: 10.1038/s41419-020-2523-z) (PMID:32366892) (PMCID:PMC7198490)

Michalopoulou, Evdokia, Auciello, Francesca R., Bulusu, Vinay, Strachan, David, Campbell, Andrew D., Tait-Mulder, Jacqueline, Karim, Saadia A., Morton, Jennifer P. ORCID: https://orcid.org/0000-0001-5766-9141, Sansom, Owen J. ORCID: https://orcid.org/0000-0001-9540-3010 and Kamphorst, Jurre J. ORCID: https://orcid.org/0000-0002-2042-5474 (2020) Macropinocytosis renders a subset of pancreatic tumor cells resistant to mTOR inhibition. Cell Reports, 30(8), 2729-2742.e4. (doi: 10.1016/j.celrep.2020.01.080) (PMID:32101748) (PMCID:PMC7043007)

Auciello, F. R. et al. (2019) A stromal lysolipid-autotaxin signaling axis promotes pancreatic tumor progression. Cancer Discovery, 9(5), pp. 617-627. (doi: 10.1158/2159-8290.CD-18-1212) (PMID:30837243) (PMCID:PMC6497553)

Port, J. et al. (2018) Colorectal tumors require NUAK1 for protection from oxidative stress. Cancer Discovery, 8(5), pp. 632-647. (doi: 10.1158/2159-8290.CD-17-0533) (PMID:29500295) (PMCID:PMC5935231)

Monteverde, T., Tait-Mulder, J., Hedley, A,, Knight, J.R., Sansom, O.J. ORCID: https://orcid.org/0000-0001-9540-3010 and Murphy, D.J. ORCID: https://orcid.org/0000-0002-5538-5468 (2018) Calcium signalling links MYC to NUAK1. Oncogene, 37(8), pp. 982-992. (doi: 10.1038/onc.2017.394) (PMID:29106388)