Professor Justin Bower
- Honorary Professor (School of Cancer Sciences)
email:
j.bower@beatson.gla.ac.uk
The Beatson Institute for Cancer Research, Garscube Estate, Switchback Road, Bearsden, G61 1BD
Publications
2022
Yelland, T. et al. (2022) Stabilization of the RAS:PDE6D complex is a novel strategy to inhibit RAS signaling. Journal of Medicinal Chemistry, 65(3), pp. 1898-1914. (doi: 10.1021/acs.jmedchem.1c01265) (PMID:35104933) (PMCID:PMC8842248)
2019
Konczal, J., Bower, J. and Gray, C. H. (2019) Re-introducing non-optimal synonymous codons into codon-optimized constructs enhances soluble recovery of recombinant proteins from Escherichia coli. PLoS ONE, 14(4), e0215892. (doi: 10.1371/journal.pone.0215892) (PMID:31013332) (PMCID:PMC6478350)
Francis, S. et al. (2019) Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorganic and Medicinal Chemistry Letters, 29(8), pp. 1023-1029. (doi: 10.1016/j.bmcl.2019.01.035) (PMID:30773430) (PMCID:PMC6419574)
2018
Birch, J. L. et al. (2018) A novel small-molecule inhibitor of MRCK prevents radiation-driven invasion in glioblastoma. Cancer Research, 78(22), pp. 6509-6522. (doi: 10.1158/0008-5472.CAN-18-1697) (PMID:30279244)
Unbekandt, M. et al. (2018) Discovery of potent and selective MRCK inhibitors with therapeutic effect on skin cancer. Cancer Research, 78(8), pp. 2096-2114. (doi: 10.1158/0008-5472.CAN-17-2870) (PMID:29382705) (PMCID:PMC5901721)
2017
Gray, C. H., Konczal, J., Mezna, M., Ismail, S. , Bower, J. and Drysdale, M. (2017) A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB. Protein Expression and Purification, 132, pp. 75-84. (doi: 10.1016/j.pep.2017.01.010) (PMID:28137655) (PMCID:PMC5415301)
2015
Bilsland, A. E. et al. (2015) Identification of a selective G1-phase benzimidazolone inhibitor by a senescence-targeted virtual screen using artificial neural networks. Neoplasia, 17(9), pp. 704-715. (doi: 10.1016/j.neo.2015.08.009) (PMID:26476078) (PMCID:PMC4611071)
2014
Unbekandt, M. et al. (2014) A novel small-molecule MRCK inhibitor blocks cancer cell invasion. Cell Communication and Signaling, 12, 54. (doi: 10.1186/s12964-014-0054-x) (PMID:25288205) (PMCID:PMC4195943)
2013
Morley, A.D. et al. (2013) Fragment-based hit identification: thinking in 3D. Drug Discovery Today, 18(23-24), pp. 1221-1227. (doi: 10.1016/j.drudis.2013.07.011)
2012
Bower, J.F. and Pannifer, A. (2012) Using fragment-based technologies to target protein-protein interactions. Current Pharmaceutical Design, 18(30), pp. 4685-4696.
Articles
Yelland, T. et al. (2022) Stabilization of the RAS:PDE6D complex is a novel strategy to inhibit RAS signaling. Journal of Medicinal Chemistry, 65(3), pp. 1898-1914. (doi: 10.1021/acs.jmedchem.1c01265) (PMID:35104933) (PMCID:PMC8842248)
Konczal, J., Bower, J. and Gray, C. H. (2019) Re-introducing non-optimal synonymous codons into codon-optimized constructs enhances soluble recovery of recombinant proteins from Escherichia coli. PLoS ONE, 14(4), e0215892. (doi: 10.1371/journal.pone.0215892) (PMID:31013332) (PMCID:PMC6478350)
Francis, S. et al. (2019) Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorganic and Medicinal Chemistry Letters, 29(8), pp. 1023-1029. (doi: 10.1016/j.bmcl.2019.01.035) (PMID:30773430) (PMCID:PMC6419574)
Birch, J. L. et al. (2018) A novel small-molecule inhibitor of MRCK prevents radiation-driven invasion in glioblastoma. Cancer Research, 78(22), pp. 6509-6522. (doi: 10.1158/0008-5472.CAN-18-1697) (PMID:30279244)
Unbekandt, M. et al. (2018) Discovery of potent and selective MRCK inhibitors with therapeutic effect on skin cancer. Cancer Research, 78(8), pp. 2096-2114. (doi: 10.1158/0008-5472.CAN-17-2870) (PMID:29382705) (PMCID:PMC5901721)
Gray, C. H., Konczal, J., Mezna, M., Ismail, S. , Bower, J. and Drysdale, M. (2017) A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB. Protein Expression and Purification, 132, pp. 75-84. (doi: 10.1016/j.pep.2017.01.010) (PMID:28137655) (PMCID:PMC5415301)
Bilsland, A. E. et al. (2015) Identification of a selective G1-phase benzimidazolone inhibitor by a senescence-targeted virtual screen using artificial neural networks. Neoplasia, 17(9), pp. 704-715. (doi: 10.1016/j.neo.2015.08.009) (PMID:26476078) (PMCID:PMC4611071)
Unbekandt, M. et al. (2014) A novel small-molecule MRCK inhibitor blocks cancer cell invasion. Cell Communication and Signaling, 12, 54. (doi: 10.1186/s12964-014-0054-x) (PMID:25288205) (PMCID:PMC4195943)
Morley, A.D. et al. (2013) Fragment-based hit identification: thinking in 3D. Drug Discovery Today, 18(23-24), pp. 1221-1227. (doi: 10.1016/j.drudis.2013.07.011)
Bower, J.F. and Pannifer, A. (2012) Using fragment-based technologies to target protein-protein interactions. Current Pharmaceutical Design, 18(30), pp. 4685-4696.
Research datasets
2015
Bilsland, A., Pugliese, A., Liu, Y., Revie, J., Burns, S., McCormick, C., Cairney, C., Bower, J., Drysdale, M., Narita, M., Sadaie, M. and Keith, N. (2015) Identification of a selective G1-phase benzimidazolone inhibitor by a senescence-targeted virtual screen using artificial neural networks. [Data Collection]