2023

Papalazarou, V. et al. (2023) Phenotypic profiling of solute carriers characterises serine transport in cancer. Nature Metabolism, 5, pp. 2148-2168. (doi: 10.1038/s42255-023-00936-2) (PMID:38066114) (PMCID:PMC10730406)

Papalazarou, V. et al. (2023) Phenotypic profiling of solute carriers characterizes serine transport in cancer. Nature Metabolism, 5(12), pp. 2148-2168. (doi: 10.1038/s42255-023-00936-2) (PMID:38066114) (PMCID:PMC10730406)

Grotehans, N., McGarry, L., Nolte, H., Xavier, V., Kroker, M., Narbona‐Pérez, Á. J., Deshwal, S., Giavalisco, P., Langer, T. and MacVicar, T. (2023) Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression. EMBO Journal, 42(18), e113256. (doi: 10.15252/embj.2022113256) (PMID:37439264) (PMCID:PMC10505918)

Nikolatou, K. et al. (2023) PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. EMBO Journal, 42, e1139. (doi: 10.15252/embj.2023113987) (PMID:37577760) (PMCID:PMC10505920)

Sandilands, E. et al. (2023) The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels. Journal of Cell Biology, 222(4), e202206115. (doi: 10.1083/jcb.202206115) (PMID:36880595) (PMCID:PMC9997661)

Román-Fernández, A. et al. (2023) Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science Advances, 9(5), eabq1858. (doi: 10.1126/sciadv.abq1858) (PMID:36735782) (PMCID:PMC9897673)

2022

Freckmann, E. C. et al. (2022) Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging. Nature Communications, 13, 5317. (doi: 10.1038/s41467-022-32958-x) (PMID:36085324) (PMCID:PMC9463449)

Müller, M. et al. (2022) Human-correlated genetic HCC models identify combination therapy for precision medicine [Pre-print]. Research Square, (doi: 10.21203/rs.3.rs-1638504/v1)

Spiliopoulou, P. et al. (2022) Dual G9A/EZH2 inhibition stimulates anti-tumour immune response in ovarian high grade serous carcinoma. Molecular Cancer Therapeutics, 21(4), pp. 522-534. (doi: 10.1158/1535-7163.MCT-21-0743) (PMID:35131874) (PMCID:PMC9377747)

2021

McGarry, D. J., Armstrong, G., Castino, G., Mason, S., Clark, W., Shaw, R., McGarry, L., Blyth, K. and Olson, M. F. (2021) MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours. Cancer Letters, 519, pp. 226-236. (doi: 10.1016/j.canlet.2021.07.039) (PMID:34314753)

Flanagan, D. J. et al. (2021) NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. Nature, 594, pp. 430-435. (doi: 10.1038/s41586-021-03525-z) (PMID:34079124)

Nacke, M. et al. (2021) An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nature Communications, 12, 1623. (doi: 10.1038/s41467-021-21847-4) (PMID:33712589) (PMCID:PMC7955138)

Latif, A.-L. et al. (2021) BRD4-mediated repression of p53 is a target for combination therapy in AML. Nature Communications, 12, 241. (doi: 10.1038/s41467-020-20378-8) (PMID:33431824) (PMCID:PMC7801601)

2018

Román-Fernández, Á. , Roignot, J., Sandilands, E., Nacke, M., Mansour, M. A., McGarry, L., Shanks, E., Mostov, K. E. and Bryant, D. M. (2018) The phospholipid PI(3,4)P2 is an apical identity determinant. Nature Communications, 9, 5041. (doi: 10.1038/s41467-018-07464-8) (PMID:30487552) (PMCID:PMC6262019)

Rath, N. et al. (2018) Rho kinase inhibition by AT13148 blocks pancreatic ductal adenocarinoma invasion and tumor growth. Cancer Research, 78(12), pp. 3321-3336. (doi: 10.1158/0008-5472.CAN-17-1339) (PMID:29669760) (PMCID:PMC6005347)

Unbekandt, M. et al. (2018) Discovery of potent and selective MRCK inhibitors with therapeutic effect on skin cancer. Cancer Research, 78(8), pp. 2096-2114. (doi: 10.1158/0008-5472.CAN-17-2870) (PMID:29382705) (PMCID:PMC5901721)

2015

Latif, A.-L., Cole, J. J., Monteiro Campos, J., Clark, W., McGarry, L., Brock, C., Newcombe, A., Keeshan, K. , Copland, M. and Adams, P. D. (2015) Dual inhibition of MDM2 and BET cooperate to eradicate acute myeloid leukemia. Blood, 126(23), p. 674. (doi: 10.1182/blood.V126.23.674.674)

Mardilovich, K. et al. (2015) LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation. Oncotarget, 6(36), pp. 38469-38486. (doi: 10.18632/oncotarget.6288) (PMID:26540348) (PMCID:PMC4770715)

Schug, Z. T. et al. (2015) Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell, 27(1), pp. 57-71. (doi: 10.1016/j.ccell.2014.12.002) (PMID:25584894) (PMCID:PMC4297291)

Mardilovich, K., Gabrielsen, M. , McGarry, L., Orange, C., Patel, R., Shanks, E., Edwards, J. and Olson, M. F. (2015) Elevated LIM kinase 1 in nonmetastatic prostate cancer reflects its role in facilitating androgen receptor nuclear translocation. Molecular Cancer Therapeutics, 14(1), pp. 246-258. (doi: 10.1158/1535-7163.MCT-14-0447)

Dikovskaya, D. et al. (2015) Mitotic stress is an integral part of the oncogene-induced senescence program that promotes multinucleation and cell cycle arrest. Cell Reports, 12(9), pp. 1483-1496. (doi: 10.1016/j.celrep.2015.07.055) (PMID:26299965) (PMCID:PMC4562906)

Miller, B. W. et al. (2015) Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy. EMBO Molecular Medicine, 7, pp. 1063-1076. (doi: 10.15252/emmm.201404827) (PMID:26077591) (PMCID:PMC4551344)

2014

Jerby-Arnon, L. et al. (2014) Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality. Cell, 158(5), pp. 1199-1209. (doi: 10.1016/j.cell.2014.07.027) (PMID:25171417)

2013

Campbell, A.D., Lawn, S., McGarry, L.C., Welch, H.C., Ozanne, B.W. and Norman, J.C. (2013) P-rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments. PLoS ONE, 8(1), e53982. (doi: 10.1371/journal.pone.0053982) (PMID:23382862) (PMCID:PMC3559689)

Nobis, M. et al. (2013) Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of Src in pancreatic cancer. Cancer Research, 73(15), pp. 4674-4686. (doi: 10.1158/0008-5472.CAN-12-4545)

2009

Gray, C. H., McGarry, L. C., Spence, H. J., Riboldi-Tunnicliffe, A. and Ozanne, B. W. (2009) Novel  -Propeller of the BTB-Kelch Protein Krp1 Provides a Binding Site for Lasp-1 That Is Necessary for Pseudopodial Extension. Journal of Biological Chemistry, 284(44), pp. 30498-30507. (doi: 10.1074/jbc.M109.023259)

2007

MacPherson, I. , Hooper, S., Serrels, A., McGarry, L., Ozanne, B., Harrington, K., Frame, M., Sahai, E. and Brunton, V. (2007) p120-catenin is required for the collective invasion of squamous cell carcinoma cells via a phosphorylation-independent mechanism. Oncogene, 26(36), pp. 5214-5228. (doi: 10.1038/sj.onc.1210334)

Ozanne, B., Spence, H., McGarry, L. and Hennigan, R. (2007) Transcription factors control invasion: AP-1 the first among equals. Oncogene, 26(1), pp. 1-10. (doi: 10.1038/sj.onc.1209759)

2006

Tsirimonaki, E., Ullah, R., Marchetti, B., Ashrafi, G.H., McGarry, L., Ozanne, B.W. and Campo, M.S. (2006) Similarities and differences between the E5 oncoproteins of bovine papillomaviruses type 1 and type 4: Cytoskeleton, motility and invasiveness in E5-transformed bovine and mouse cells. Virus Research, 115(2), pp. 158-168. (doi: 10.1016/j.virusres.2005.08.003)

Hennigan, R., McGarry, L., Ozanne, B. and Spence, H. (2006) Invasion is a genetic program regulated by transcription factors. Current Opinion in Genetics and Development, 16(1), pp. 65-70. (doi: 10.1016/j.gde.2005.12.012)

Spence, H., McGarry, L., Chew, C., Carragher, N., Scott-Carragher, L., Yuan, Z., Croft, D., Olson, M. , Frame, M. and Ozanne, B. (2006) AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins. Molecular and Cellular Biology, 26(4), pp. 1480-1495. (doi: 10.1128/MCB.26.4.1480-1495.2006)

2000

Johnston, I. M.P., Spence, H. J., Winnie, J. N., McGarry, L., Vass, J. K., Meagher, L., Stapleton, G. and Ozanne, B. W. (2000) Regulation of a multigenic invasion programme by the transcription factor, AP-1: re-expression of a down-regulated gene, TSC-36, inhibits invasion. Oncogene, 19(47), pp. 5348-5358. (doi: 10.1038/sj.onc.1203927) (PMID:11103936)

Ozanne, B. W., McGarry, L., Spence, H. J., Johnstone, I., Winnie, J., Meagher, L. and Stapleton, G. (2000) Transcriptional regulation of cell invasion: AP-1 regulation of a multigenic invasion programme. European Journal of Cancer, 36(13), pp. 1640-1648. (doi: 10.1016/S0959-8049(00)00175-1) (PMID:10959050)

Articles

Papalazarou, V. et al. (2023) Phenotypic profiling of solute carriers characterises serine transport in cancer. Nature Metabolism, 5, pp. 2148-2168. (doi: 10.1038/s42255-023-00936-2) (PMID:38066114) (PMCID:PMC10730406)

Papalazarou, V. et al. (2023) Phenotypic profiling of solute carriers characterizes serine transport in cancer. Nature Metabolism, 5(12), pp. 2148-2168. (doi: 10.1038/s42255-023-00936-2) (PMID:38066114) (PMCID:PMC10730406)

Grotehans, N., McGarry, L., Nolte, H., Xavier, V., Kroker, M., Narbona‐Pérez, Á. J., Deshwal, S., Giavalisco, P., Langer, T. and MacVicar, T. (2023) Ribonucleotide synthesis by NME6 fuels mitochondrial gene expression. EMBO Journal, 42(18), e113256. (doi: 10.15252/embj.2022113256) (PMID:37439264) (PMCID:PMC10505918)

Nikolatou, K. et al. (2023) PTEN deficiency exposes a requirement for an ARF GTPase module for integrin-dependent invasion in ovarian cancer. EMBO Journal, 42, e1139. (doi: 10.15252/embj.2023113987) (PMID:37577760) (PMCID:PMC10505920)

Sandilands, E. et al. (2023) The small GTPase ARF3 controls invasion modality and metastasis by regulating N-cadherin levels. Journal of Cell Biology, 222(4), e202206115. (doi: 10.1083/jcb.202206115) (PMID:36880595) (PMCID:PMC9997661)

Román-Fernández, A. et al. (2023) Spatial regulation of the glycocalyx component podocalyxin is a switch for prometastatic function. Science Advances, 9(5), eabq1858. (doi: 10.1126/sciadv.abq1858) (PMID:36735782) (PMCID:PMC9897673)

Freckmann, E. C. et al. (2022) Traject3d allows label-free identification of distinct co-occurring phenotypes within 3D culture by live imaging. Nature Communications, 13, 5317. (doi: 10.1038/s41467-022-32958-x) (PMID:36085324) (PMCID:PMC9463449)

Müller, M. et al. (2022) Human-correlated genetic HCC models identify combination therapy for precision medicine [Pre-print]. Research Square, (doi: 10.21203/rs.3.rs-1638504/v1)

Spiliopoulou, P. et al. (2022) Dual G9A/EZH2 inhibition stimulates anti-tumour immune response in ovarian high grade serous carcinoma. Molecular Cancer Therapeutics, 21(4), pp. 522-534. (doi: 10.1158/1535-7163.MCT-21-0743) (PMID:35131874) (PMCID:PMC9377747)

McGarry, D. J., Armstrong, G., Castino, G., Mason, S., Clark, W., Shaw, R., McGarry, L., Blyth, K. and Olson, M. F. (2021) MICAL1 regulates actin cytoskeleton organization, directional cell migration and the growth of human breast cancer cells as orthotopic xenograft tumours. Cancer Letters, 519, pp. 226-236. (doi: 10.1016/j.canlet.2021.07.039) (PMID:34314753)

Flanagan, D. J. et al. (2021) NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. Nature, 594, pp. 430-435. (doi: 10.1038/s41586-021-03525-z) (PMID:34079124)

Nacke, M. et al. (2021) An ARF GTPase module promoting invasion and metastasis through regulating phosphoinositide metabolism. Nature Communications, 12, 1623. (doi: 10.1038/s41467-021-21847-4) (PMID:33712589) (PMCID:PMC7955138)

Latif, A.-L. et al. (2021) BRD4-mediated repression of p53 is a target for combination therapy in AML. Nature Communications, 12, 241. (doi: 10.1038/s41467-020-20378-8) (PMID:33431824) (PMCID:PMC7801601)

Román-Fernández, Á. , Roignot, J., Sandilands, E., Nacke, M., Mansour, M. A., McGarry, L., Shanks, E., Mostov, K. E. and Bryant, D. M. (2018) The phospholipid PI(3,4)P2 is an apical identity determinant. Nature Communications, 9, 5041. (doi: 10.1038/s41467-018-07464-8) (PMID:30487552) (PMCID:PMC6262019)

Rath, N. et al. (2018) Rho kinase inhibition by AT13148 blocks pancreatic ductal adenocarinoma invasion and tumor growth. Cancer Research, 78(12), pp. 3321-3336. (doi: 10.1158/0008-5472.CAN-17-1339) (PMID:29669760) (PMCID:PMC6005347)

Unbekandt, M. et al. (2018) Discovery of potent and selective MRCK inhibitors with therapeutic effect on skin cancer. Cancer Research, 78(8), pp. 2096-2114. (doi: 10.1158/0008-5472.CAN-17-2870) (PMID:29382705) (PMCID:PMC5901721)

Latif, A.-L., Cole, J. J., Monteiro Campos, J., Clark, W., McGarry, L., Brock, C., Newcombe, A., Keeshan, K. , Copland, M. and Adams, P. D. (2015) Dual inhibition of MDM2 and BET cooperate to eradicate acute myeloid leukemia. Blood, 126(23), p. 674. (doi: 10.1182/blood.V126.23.674.674)

Mardilovich, K. et al. (2015) LIM kinase inhibitors disrupt mitotic microtubule organization and impair tumor cell proliferation. Oncotarget, 6(36), pp. 38469-38486. (doi: 10.18632/oncotarget.6288) (PMID:26540348) (PMCID:PMC4770715)

Schug, Z. T. et al. (2015) Acetyl-CoA synthetase 2 promotes acetate utilization and maintains cancer cell growth under metabolic stress. Cancer Cell, 27(1), pp. 57-71. (doi: 10.1016/j.ccell.2014.12.002) (PMID:25584894) (PMCID:PMC4297291)

Mardilovich, K., Gabrielsen, M. , McGarry, L., Orange, C., Patel, R., Shanks, E., Edwards, J. and Olson, M. F. (2015) Elevated LIM kinase 1 in nonmetastatic prostate cancer reflects its role in facilitating androgen receptor nuclear translocation. Molecular Cancer Therapeutics, 14(1), pp. 246-258. (doi: 10.1158/1535-7163.MCT-14-0447)

Dikovskaya, D. et al. (2015) Mitotic stress is an integral part of the oncogene-induced senescence program that promotes multinucleation and cell cycle arrest. Cell Reports, 12(9), pp. 1483-1496. (doi: 10.1016/j.celrep.2015.07.055) (PMID:26299965) (PMCID:PMC4562906)

Miller, B. W. et al. (2015) Targeting the LOX/hypoxia axis reverses many of the features that make pancreatic cancer deadly: inhibition of LOX abrogates metastasis and enhances drug efficacy. EMBO Molecular Medicine, 7, pp. 1063-1076. (doi: 10.15252/emmm.201404827) (PMID:26077591) (PMCID:PMC4551344)

Jerby-Arnon, L. et al. (2014) Predicting cancer-specific vulnerability via data-driven detection of synthetic lethality. Cell, 158(5), pp. 1199-1209. (doi: 10.1016/j.cell.2014.07.027) (PMID:25171417)

Campbell, A.D., Lawn, S., McGarry, L.C., Welch, H.C., Ozanne, B.W. and Norman, J.C. (2013) P-rex1 cooperates with PDGFRβ to drive cellular migration in 3D microenvironments. PLoS ONE, 8(1), e53982. (doi: 10.1371/journal.pone.0053982) (PMID:23382862) (PMCID:PMC3559689)

Nobis, M. et al. (2013) Intravital FLIM-FRET imaging reveals dasatinib-induced spatial control of Src in pancreatic cancer. Cancer Research, 73(15), pp. 4674-4686. (doi: 10.1158/0008-5472.CAN-12-4545)

Gray, C. H., McGarry, L. C., Spence, H. J., Riboldi-Tunnicliffe, A. and Ozanne, B. W. (2009) Novel  -Propeller of the BTB-Kelch Protein Krp1 Provides a Binding Site for Lasp-1 That Is Necessary for Pseudopodial Extension. Journal of Biological Chemistry, 284(44), pp. 30498-30507. (doi: 10.1074/jbc.M109.023259)

MacPherson, I. , Hooper, S., Serrels, A., McGarry, L., Ozanne, B., Harrington, K., Frame, M., Sahai, E. and Brunton, V. (2007) p120-catenin is required for the collective invasion of squamous cell carcinoma cells via a phosphorylation-independent mechanism. Oncogene, 26(36), pp. 5214-5228. (doi: 10.1038/sj.onc.1210334)

Ozanne, B., Spence, H., McGarry, L. and Hennigan, R. (2007) Transcription factors control invasion: AP-1 the first among equals. Oncogene, 26(1), pp. 1-10. (doi: 10.1038/sj.onc.1209759)

Tsirimonaki, E., Ullah, R., Marchetti, B., Ashrafi, G.H., McGarry, L., Ozanne, B.W. and Campo, M.S. (2006) Similarities and differences between the E5 oncoproteins of bovine papillomaviruses type 1 and type 4: Cytoskeleton, motility and invasiveness in E5-transformed bovine and mouse cells. Virus Research, 115(2), pp. 158-168. (doi: 10.1016/j.virusres.2005.08.003)

Hennigan, R., McGarry, L., Ozanne, B. and Spence, H. (2006) Invasion is a genetic program regulated by transcription factors. Current Opinion in Genetics and Development, 16(1), pp. 65-70. (doi: 10.1016/j.gde.2005.12.012)

Spence, H., McGarry, L., Chew, C., Carragher, N., Scott-Carragher, L., Yuan, Z., Croft, D., Olson, M. , Frame, M. and Ozanne, B. (2006) AP-1 differentially expressed proteins Krp1 and fibronectin cooperatively enhance Rho-ROCK-independent mesenchymal invasion by altering the function, localization, and activity of nondifferentially expressed proteins. Molecular and Cellular Biology, 26(4), pp. 1480-1495. (doi: 10.1128/MCB.26.4.1480-1495.2006)

Johnston, I. M.P., Spence, H. J., Winnie, J. N., McGarry, L., Vass, J. K., Meagher, L., Stapleton, G. and Ozanne, B. W. (2000) Regulation of a multigenic invasion programme by the transcription factor, AP-1: re-expression of a down-regulated gene, TSC-36, inhibits invasion. Oncogene, 19(47), pp. 5348-5358. (doi: 10.1038/sj.onc.1203927) (PMID:11103936)

Ozanne, B. W., McGarry, L., Spence, H. J., Johnstone, I., Winnie, J., Meagher, L. and Stapleton, G. (2000) Transcriptional regulation of cell invasion: AP-1 regulation of a multigenic invasion programme. European Journal of Cancer, 36(13), pp. 1640-1648. (doi: 10.1016/S0959-8049(00)00175-1) (PMID:10959050)