Dr Justin Bower

  • Affiliate (Institute of Cancer Sciences)

email: j.bower@beatson.gla.ac.uk

Beatson Institute, Garscube Estate

Publications

List by: Type | Date

Jump to: 2019 | 2018 | 2017 | 2015 | 2014 | 2013 | 2012
Number of items: 9.

2019

Konczal, J., Bower, J. and Gray, C. H. (2019) Re-introducing non-optimal synonymous codons into codon-optimized constructs enhances soluble recovery of recombinant proteins from Escherichia coli. PLoS ONE, 14(4), e0215892. (doi: 10.1371/journal.pone.0215892) (PMID:31013332) (PMCID:PMC6478350)

Francis, S. et al. (2019) Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorganic and Medicinal Chemistry Letters, 29(8), pp. 1023-1029. (doi: 10.1016/j.bmcl.2019.01.035) (PMID:30773430) (PMCID:PMC6419574)

2018

Birch, J. L. et al. (2018) A novel small-molecule inhibitor of MRCK prevents radiation-driven invasion in glioblastoma. Cancer Research, 78(22), pp. 6509-6522. (doi: 10.1158/0008-5472.CAN-18-1697) (PMID:30279244)

Unbekandt, M. et al. (2018) Discovery of potent and selective MRCK inhibitors with therapeutic effect on skin cancer. Cancer Research, 78(8), pp. 2096-2114. (doi: 10.1158/0008-5472.CAN-17-2870) (PMID:29382705) (PMCID:PMC5901721)

2017

Gray, C. H., Konczal, J., Mezna, M., Ismail, S. , Bower, J. and Drysdale, M. (2017) A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB. Protein Expression and Purification, 132, pp. 75-84. (doi: 10.1016/j.pep.2017.01.010) (PMID:28137655) (PMCID:PMC5415301)

2015

Bilsland, A. E. et al. (2015) Identification of a selective G1-phase benzimidazolone inhibitor by a senescence-targeted virtual screen using artificial neural networks. Neoplasia, 17(9), pp. 704-715. (doi: 10.1016/j.neo.2015.08.009) (PMID:26476078) (PMCID:PMC4611071)

2014

Unbekandt, M. et al. (2014) A novel small-molecule MRCK inhibitor blocks cancer cell invasion. Cell Communication and Signaling, 12, 54. (doi: 10.1186/s12964-014-0054-x) (PMID:25288205) (PMCID:PMC4195943)

2013

Morley, A.D. et al. (2013) Fragment-based hit identification: thinking in 3D. Drug Discovery Today, 18(23-24), pp. 1221-1227. (doi: 10.1016/j.drudis.2013.07.011)

2012

Bower, J.F. and Pannifer, A. (2012) Using fragment-based technologies to target protein-protein interactions. Current Pharmaceutical Design, 18(30), pp. 4685-4696.

This list was generated on Mon Nov 29 17:13:47 2021 GMT.
Jump to: Articles
Number of items: 9.

Articles

Konczal, J., Bower, J. and Gray, C. H. (2019) Re-introducing non-optimal synonymous codons into codon-optimized constructs enhances soluble recovery of recombinant proteins from Escherichia coli. PLoS ONE, 14(4), e0215892. (doi: 10.1371/journal.pone.0215892) (PMID:31013332) (PMCID:PMC6478350)

Francis, S. et al. (2019) Structure-based design, synthesis and biological evaluation of a novel series of isoquinolone and pyrazolo[4,3-c]pyridine inhibitors of fascin 1 as potential anti-metastatic agents. Bioorganic and Medicinal Chemistry Letters, 29(8), pp. 1023-1029. (doi: 10.1016/j.bmcl.2019.01.035) (PMID:30773430) (PMCID:PMC6419574)

Birch, J. L. et al. (2018) A novel small-molecule inhibitor of MRCK prevents radiation-driven invasion in glioblastoma. Cancer Research, 78(22), pp. 6509-6522. (doi: 10.1158/0008-5472.CAN-18-1697) (PMID:30279244)

Unbekandt, M. et al. (2018) Discovery of potent and selective MRCK inhibitors with therapeutic effect on skin cancer. Cancer Research, 78(8), pp. 2096-2114. (doi: 10.1158/0008-5472.CAN-17-2870) (PMID:29382705) (PMCID:PMC5901721)

Gray, C. H., Konczal, J., Mezna, M., Ismail, S. , Bower, J. and Drysdale, M. (2017) A fully automated procedure for the parallel, multidimensional purification and nucleotide loading of the human GTPases KRas, Rac1 and RalB. Protein Expression and Purification, 132, pp. 75-84. (doi: 10.1016/j.pep.2017.01.010) (PMID:28137655) (PMCID:PMC5415301)

Bilsland, A. E. et al. (2015) Identification of a selective G1-phase benzimidazolone inhibitor by a senescence-targeted virtual screen using artificial neural networks. Neoplasia, 17(9), pp. 704-715. (doi: 10.1016/j.neo.2015.08.009) (PMID:26476078) (PMCID:PMC4611071)

Unbekandt, M. et al. (2014) A novel small-molecule MRCK inhibitor blocks cancer cell invasion. Cell Communication and Signaling, 12, 54. (doi: 10.1186/s12964-014-0054-x) (PMID:25288205) (PMCID:PMC4195943)

Morley, A.D. et al. (2013) Fragment-based hit identification: thinking in 3D. Drug Discovery Today, 18(23-24), pp. 1221-1227. (doi: 10.1016/j.drudis.2013.07.011)

Bower, J.F. and Pannifer, A. (2012) Using fragment-based technologies to target protein-protein interactions. Current Pharmaceutical Design, 18(30), pp. 4685-4696.

This list was generated on Mon Nov 29 17:13:47 2021 GMT.

Research datasets

Jump to: 2015
Number of items: 1.

2015

Bilsland, A., Pugliese, A., Liu, Y., Revie, J., Burns, S., McCormick, C., Cairney, C., Bower, J., Drysdale, M., Narita, M., Sadaie, M. and Keith, N. (2015) Identification of a selective G1-phase benzimidazolone inhibitor by a senescence-targeted virtual screen using artificial neural networks. [Data Collection]

This list was generated on Mon Nov 29 03:02:57 2021 GMT.