Microscope slide showing healthy human colon

The body’s mucosal tissues, especially the lungs and intestines, have a vast surface area and provide the most important sites for our interactions with the environment. They are exposed to a multitude of microbes and are home to the majority of our immune cells. To enable optimal function of these vital organs, the mucosal immune system must protect us from pathogens, while tolerating commensal organisms, food proteins and benign antigens.

Immunologists in the Mucosal Immunology theme are engaged in cutting-edge basic and translational science, aimed at understanding the molecular and cellular processes that control immune responses in mucosal tissues. These studies range from investigations of interactions with bacterial pathogens and commensal organisms, through studying how specific cytokines control immune responses to parasite infections, to studies aimed directly at identifying novel therapies for human inflammatory disease.

We work closely together with the other themes within the Centre for Immunobiology, and also with our clinical colleagues, to utilise our excellent flow cytometry, microscopy and multi-omics facilities, to better understand the mucosal immune system to improve human health.

 

 

Dr Calum Bain | Reader (Immunology & Infection)

I am an immunologist with an interest in the fundamental biology of innate immune cells, particularly monocytes and macrophages. These cells are crucial for normal development, tissue health and protective immunity, but they also become dysregulated and disease-promoting in chronic inflammatory and fibrotic diseases. Our lab focusses on understanding how essential peacekeeper cells can become power aggressors in the context of disease.

 ‌‌A head and shoulders portrait shot od Dr Calum Bain

Dr Claire Bourke | Senior Lecturer in Immunology

My research focuses on the immunobiology of child malnutrition, including its origins in pregnancy. Using cell and tissue samples from affected communities, my group uses translational immunology approaches to understand how the immune system contributes to the short and long-term health inequalities of malnutrition.

 ‌‌A head and shoulders shot of Dr Claire Bourke

Dr Shaun Chuah | Clinical Senior Research Fellow

My research interests are in applying the advances in machine learning and AI to deepen our understanding of inflammatory bowel disease and other immune-mediated inflammatory diseases, stratify patients for mechanistic studies, and enhance clinical care.

 ‌‌A head and shoulders portrait shot of Dr Shaun Chuah

Prof Paul Garside | Senior Advisory Fellow (MVLS Senior Management)

I study fundmental aspects of immune tolerance and priming and translate findings into the contexts of infectious and autoimmune disease.

 ‌‌A head and shoulders shot of Professor Paul Garside

Prof Robert Gray | Professor of Respiratory Medicine

I am Professor of Respiratory Medicine and Co-Deputy Head of the School of Infection & Immunity. I study inflammation and repair in the airway with a focus on diseases such as Cystic Fibrosis and COPD.

 ‌‌A head and shoulders portrait shot of Professor Robert Gray set against a white background

Prof Gwo-tzer Ho | Professor of Gastroenterology

I have a strong interest in understanding the processes that govern gut mucosal healing in Crohn’s disease and Ulcerative colitis; and bridging discovery science to the clinic. I also continue to care for IBD patients in the clinic and maintain a keen interest in patient-public engagement.

 ‌‌A head and shoulders portrait shot of Professor Gwo-tzer Ho

Dr Gareth-Rhys Jones | Clinical Senior Research Fellow

I am a gastroenterologist and new group leader in human gut immunology. He is an IBD physician and mucosal immunologist who is interested in how myeloid cells influence gut inflammation and healing.

 ‌‌A head and shoulders portrait shot of Dr Gareth-Rhys Jones

Dr Megan MacLeod | Senior Lecturer (Immunology)

My expertise is in immunological memory - understanding how past infections and inflammatory events shape our future immune responses. We want to know how memory immune cells function, how they influence the environments in which they live, and how these environments feedback on the memory cells. We aim for the new knowledge we learn to open up avenues to improve the functions of immune memory cells by vaccination and to inhibit these cells when they are root cause of disease, for example in autoimmunity.

 ‌‌A head and shoulders profile shot of Dr Megan MacLeod

Professor Rick Maizels | Professor (Parasitology)

The Maizels Lab studies how parasites manipulate the immune system through secreted immunomodulators, and how those modulators might offer novel anti-inflammatory therapies.

 ‌‌A head and shoulders profile shot of Professor Rick Maizels in the lab

Prof Kevin Maloy | Professor Mucosal Immunology

I’m a mucosal immunologist, studying immune responses in the intestinal tract and their impact on protective immunity and harmful inflammation.

 ‌‌A head and shoulders shot of Kevin Maloy

Prof Simon Milling | Deputy Head of Immunology

My lab focusses on the immunology of the intestine. We study cellular and mechanisms by which macrophages and dendritic cells control intestinal immune responses. We translate these insights in studies of human inflammatory and autoimmune diseases including ankylosing spondylitis, psoriatic arthritis, inflammatory bowel disease, and alopecia areata.

 ‌‌A head and shoulders shot of Professor Simon Milling

Dr Aurelie Najm | Clinical Senior Research Fellow

My research interests are strongly interlinked with my clinical practice; where I am mainly involved in the care of people living with rheumatoid arthritis and psoriatic arthritis. I have developed 3 main areas of research: 1. Synovial tissue biology and identification of new therapeutic targets. I am the lead of the synovial biopsy program in Glasgow as part of many different research collaborations and programs. I have been co-chairing the EULAR - European Alliance of Associations for Rheumatology- Synovitis study group from 2018-2022. 2. Epigenetic aspects of Interstitial Lung Disease: EPI-ILD. This 3 years FOREUM funded project aims at unravelling myeloid epigenetic signatures in Interstitial Lung Disease associated to Rheumatoid Arthritis and Systemic Sclerosis. 3. Digital health: I am a strong believer that digital health solutions have a potential to transform and improve clinical care and research. I have coordinated several EULAR projects on this topic.

 A head and shoulders shot of Dr Aurelie Najm wearing a pink sweater 

Dr Georgia Perona-Wright | Honorary Senior Lecturer (Immunology)

Understanding infection immunology, at the infection site. Interested in immune balance, cytokines, metabolic regulation, and co-infection

 ‌‌A head and shoulders shot of Dr Georgia Perona-Wright

Dr Miguel Pineda | Lecturer (Molecular Biosciences)

Glycans - sugars - are the dominant molecules on cell surfaces, and glycan remodeling affects cell-cell interactions, migration, adhesion or receptor binding, all of them core mechanisms underpinning immune responses. Tissue glycosylation changes in response to inflammation, diet or infection. Therefore, could changes in gut glycosylation modulate gut immunology? My goal is to describe the function of glycosylation in gut immunology, both in healthy and inflammatory conditions. 

 ‌‌A head and shoulders shot of Miguel Pineda in the office

Dr Nicola Robinson | Senior Clinical Research Fellow

 

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Prof Stefan Siebert | Inflammation Medicine & Rheumatology

I have clinical and academic interests in the interactions of mucosal immunology and inflammatory arthritis, particularly in axial spondyloarthritis where these are closely related.

 ‌‌A head and shoulders shot of Stefan Siebert