Dr Megan MacLeod
- Senior Lecturer (Immunology & Infection)
Dr Megan MacLeod graduated from the University of Glasgow with a BSc in Immunology in 2001 and the University of Edinburgh with a PhD in immunology in 2005. Her PhD, completed in Prof David Gray’s lab, focussed on the requirement for costimulation in the generation and re-activation of memory CD4 T cells.
Dr MacLeod continued to work on memory CD4 T cells during her postdoc with Pippa Marrack and John Kappler at National Jewish Health in Denver, CO, USA.
She then joined the University of Glasgow in 2012 with a Career Development Research Fellowship from Arthritis Research UK to study the induction of tolerance in memory CD4 T cells.
Dr MacLeod, who became a lecturer in 2017 and a senior lecturer in 2019, and her lab continue to examine the fundamental differences between naïve and memory T cells and to investigate the interactions between immune cells and local stromal cells following viral infection.
An active member of the British Society for Immunology, she also serves as the Scottish representative on the BSI’s Forum - the think tank for the organisation - as well as the secretary of the West of Scotland Immunology Group (WSIG).
The WSIG arrange five to six seminars each year presented by world-leading immunologists. Please see their website for more information.
Dr MacLeod's expertise lies in immunological memory: understanding how past infections and inflammatory insults affect subsequent immune responses.
Immune memory cells are generated following primary immune responses and can provide superior immune protection.
However, memory cells can also be responsible for damage to the host - in autoimmune diseases such as rheumatoid arthritis, for example.
Her lab is interested in how memory cells are generated and the how their responses can be increased to improve immune protection or decreased to reduce immune-pathology.
They want to know how memory cells function within the context of the tissues they act and how tissues change to support and regulate memory cells.
By addressing these questions, they will open new avenues to improve their responses in vaccination and inhibit them in autoimmune diseases.
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Dissecting innate immune determinants of severity and resolution in a longitudinal study of COVID-19
2020 - 2022
- Communication between lung immune and stromal cells drives tissue protective immune memory
2018 - 2023
- SHARC: Synovial Hyperplasia in Athritis and Cancer
2018 - 2018
- Afterglow and Immunecraft: digital artists reimagine scientific research
2016 - 2017
- Epigenetic basis of immunological memory
2015 - 2016
- Investigating The Molecular Basis for Stromal Memory Following Influenza Virus Infection (ISSF Catalyst)
2014 - 2015
- CD4INEar: Defining the cellular interactions that control the retention of and tolerance induction in CD4 T cells at inflammatory sites
2014 - 2017
- Characterisation of a novel transgenic mouse for the detection of pathogen specific memory CD4 T cells
2012 - 2013
- Molecular requirements for the induction of tolerance in activated and memory CD4 T cells.
2012 - 2018
- RSE/CRF Biomedical Personal Research Fellowship
2012 - 2012