Dr Megan MacLeod

  • Lecturer (Immunology)

telephone: 0141 330 8150
email: Megan.Macleod@glasgow.ac.uk

Biography

I graduated from the University of Glasgow with a BSc in Immunology in 2001 and the University of Edinburgh with a PhD in immunology in 2005. My PhD, completed in Prof David Gray’s lab, focussed on the requirement for costimulation in the generation and re-activation of memory CD4 T cells.

I continued to work on memory CD4 T cells during my postdoc with Pippa Marrack and John Kappler at National Jewish Health in Denver, CO, USA. I joined the University of Glasgow in 2012 with a Career Development Research Fellowship from Arthritis Research UK to study the induction of tolerance in memory CD4 T cells. I became a lecturer in 2017 continuing my research into the fundamental differences between naïve and memory T cells.

Research interests

My expertise lies in immunological memory: understanding how past infections and inflammatory insults affect subsequent immune responses. Immune memory cells are generated following primary immune responses and can provide superior immune protection. But memory cells can also be responsible for damage to the host, for example in autoimmune diseases such as rheumatoid arthritis.

My lab is interested in how memory cells are generated and the how their responses can be increased to improve immune protection or decreased to reduce immune-pathology. We want to know how memory cells function within the context of the tissues they act and how tissues change to support and regulate memory cells.

By addressing these questions, we will open new avenues to improve their responses in vaccination and inhibit them in autoimmune diseases.

Details of my Public Engagement activities

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • SHARC: Synovial Hyperplasia in Athritis and Cancer
    Cancer Research UK
    2018 - 2018
     
  • Afterglow and Immunecraft: digital artists reimagine scientific research
    British Society for Immunology
    2016 - 2017
     
  • Epigenetic basis of immunological memory
    The Carnegie Trust for the Universities of Scotland
    2015 - 2016
     
  • Investigating The Molecular Basis for Stromal Memory Following Influenza Virus Infection (ISSF Catalyst)
    Wellcome Trust
    2014 - 2015
     
  • CD4INEar: Defining the cellular interactions that control the retention of and tolerance induction in CD4 T cells at inflammatory sites
    European Commission
    2014 - 2017
     
  • Characterisation of a novel transgenic mouse for the detection of pathogen specific memory CD4 T cells
    Tenovus Scotland
    2012 - 2013
     
  • Molecular requirements for the induction of tolerance in activated and memory CD4 T cells.
    Arthritis Research UK
    2012 - 2018
     
  • RSE/CRF Biomedical Personal Research Fellowship
    The Royal Society of Edinburgh
    2012 - 2012
     

Publications

List by: Type | Date

Jump to: 2018 | 2017 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2003 | 2002
Number of items: 31.

2018

Gray, J. I., Westerhof, L. M. and Macleod, M. K.L. (2018) The roles of resident, central and effector memory CD4 T cells in protective immunity following infection or vaccination. Immunology, (doi:10.1111/imm.12929) (PMID:29570776) (Early Online Publication)

2017

Jaigrdar, S. A., Benson, R. A., Elmesmari, A., Kurowska-Stolarska, M. S. , McInnes, I. B. , Garside, P. and Macleod, M. K.L. (2017) Sphingosine-1-phosphate promotes the persistence of activated CD4 T cells in inflamed sites. Frontiers in Immunology, 8, 1627. (doi:10.3389/fimmu.2017.01627) (PMID:29225602) (PMCID:PMC5705559)

Benson, R. A., Lawton, J. C. and MacLeod, M. K.L. (2017) T cell response in the lung following influenza virus infection. In: Rainger, G. E. and Mcgettrick, H. M. (eds.) T-Cell Trafficking: Methods and Protocols. Series: Methods in molecular biology (1591). Springer: New York, pp. 235-248. ISBN 9781493969296 (doi:10.1007/978-1-4939-6931-9_17)

2015

Jaigirdar, S. A. and Macleod, M. K.L. (2015) Development and function of protective and pathologic memory CD4 T cells. Frontiers in Immunology, 6, 456. (doi:10.3389/fimmu.2015.00456) (PMID:26441961) (PMCID:PMC4561815)

Macleod, M. K.L. and Anderton, S. M. (2015) Antigen-based immunotherapy (AIT) for autoimmune and allergic disease. Current Opinion in Pharmacology, 23, pp. 11-16. (doi:10.1016/j.coph.2015.05.003) (PMID:26004365)

Oliver-Bell, J., Butcher, J.P., Malcolm, J. , Macleod, M.K.L. , Adrados Planell, A., Campbell, L., Nibbs, R.J.B., Garside, P., McInnes, I.B. and Culshaw, S. (2015) Periodontitis in the absence of B cells and specific anti-bacterial antibody. Oral Microbiology and Immunology, 30(2), pp. 160-169. (doi:10.1111/omi.12082) (PMID:25219939)

Benson, R. A., Macleod, M. K.L., Hale, B. G.H. , Patakas, A., Garside, P. and Brewer, J. M. (2015) Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo. eLife, 4, e06994. (doi:10.7554/eLife.06994) (PMID:26258879) (PMCID:PMC4558563)

2014

David, A., Trigunaite, A., Macleod, M. K., Johnson, A. C., Marrack, P. and Jørgensen, T. N. (2014) Intrinsic autoimmune capacities of hematopoietic cells from female New Zealand hybrid mice. Genes and Immunity, 15(3), pp. 153-161. (doi:10.1038/gene.2014.2) (PMID:24477163) (PMCID:PMC3999239)

David, A., Crawford, F., Garside, P., Kappler, J. W., Marrack, P. and Macleod, M. (2014) Tolerance induction in memory CD4 T cells requires two rounds of antigen-specific activation. Proceedings of the National Academy of Sciences of the United States of America, 111(21), pp. 7735-7740. (doi:10.1073/pnas.1406218111) (PMID:24821788) (PMCID:PMC4040609)

2013

Huang, Y. et al. (2013) Antigen-specific regulation of IgE antibodies by non-antigen-specific T cells. Journal of Immunology, 190(3), pp. 913-921. (doi:10.4049/jimmunol.1202230)

Macleod, M.K.L., David, A., Jin, N., Noges, L., Wang, J., Kappler, J.W. and Marrack, P. (2013) Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza virus that expresses an altered nucleoprotein sequence. PLoS ONE, 8(4), e61775. (doi:10.1371/journal.pone.0061775) (PMID:23613928) (PMCID:PMC3629017)

2012

Aviszus, K., Macleod, M., Kirchenbaum, G.A., Detanico, D.O., Heiser, R.A., St. Clair, J.B., Guo, W.J. and Wysocki, L.J. (2012) Antigen specific suppression of humoral immunity by anergic Ars/A1 B cells. Journal of Immunology, 189(9), pp. 4275-4283.

Bosio, C.M., Macleod, M., Marrack, P. and Kedl, R.M. (2012) Utility of mouse models in vaccine design and development. In: Morrow, W.J.W., Sheikh, N.A., Schmidt, C.S. and Davies, H. (eds.) Vaccinology: Principles and Practices. Wiley-Blackwell: Chichester, UK. ISBN 9781405185745 (doi:10.1002/9781118345313.ch7)

2011

MacLeod, M.K.L., David, A., McKee, A.S., Crawford, F., Kappler, J.W. and Marrack, P. (2011) Memory CD4 T cells that express CXCR5 provide accelerated help to B cells. Journal of Immunology, 186(5), pp. 2889-2896. (doi:10.4049/jimmunol.1002955)

MacLeod, M.K.L., McKee, A.S., David, A., Wang, J., Mason, R., Kappler, J.W. and Marrack, P. (2011) Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells. Proceedings of the National Academy of Sciences of the United States of America, 108(19), pp. 7914-7919. (doi:10.1073/pnas.1104588108)

2010

MacLeod, M.K.L., Kappler, J.W. and Marrack, P. (2010) Memory CD4 T cells: generation, reactivation and re-assignment. Immunology, 130(1), pp. 10-15. (doi:10.1111/j.1365-2567.2010.03260.x)

Marrack, P., Scott-Browne, J. and MacLeod, M.K.L. (2010) Terminating the immune response. Immunological Reviews, 236(1), pp. 5-10. (doi:10.1111/j.1600-065X.2010.00928.x)

McKee, A.S., MacLeod, M.K.L., Kappler, J.W. and Marrack, P. (2010) Immune mechanisms of protection: can adjuvants rise to the challenge? BMC Biology, 8(1), p. 37. (doi:10.1186/1741-7007-8-37)

Munks, M.W., McKee, A.S., MacLeod, M.K.L., Powell, R.L., Degen, J.L., Reisdorph, N.A., Kappler, J.W. and Marrack, P. (2010) Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo. Blood, 116(24), pp. 5191-5199. (doi:10.1182/blood-2010-03-275529)

2009

MacLeod, M.K.L., Clambey, E.T., Kappler, J.W. and Marrack, P. (2009) CD4 memory T cells: What are they and what can they do? Seminars in Immunology, 21(2), pp. 53-61. (doi:10.1016/j.smim.2009.02.006)

McKee, A.S., Munks, M.W., MacLeod, M.K.L., Fleenor, C.J., Van Rooijen, N., Kappler, J.W. and Marrack, P. (2009) Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. Journal of Immunology, 183(7), pp. 4403-4414. (doi:10.4049/jimmunol.0900164)

2008

Macleod, M. K. L., McKee, A., Crawford, F., White, J., Kappler, J. and Marrack, P. (2008) CD4 memory T cells divide poorly in response to antigen because of their cytokine profile. Proceedings of the National Academy of Sciences of the United States of America, 105(38), pp. 14521-14526. (doi:10.1073/pnas.0807449105) (PMID:18787120) (PMCID:PMC2533680)

McKee, A. S., Macleod, M., White, J., Crawford, F., Kappler, J. W. and Marrack, P. (2008) Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses. International Immunology, 20(5), pp. 659-669. (doi:10.1093/intimm/dxn025) (PMID:18343889) (PMCID:PMC2935467)

Yang, B., Gay, D. L., Macleod, M. K.L., Cao, X., Hala, T., Sweezer, E. M., Kappler, J., Marrack, P. and Oliver, P. M. (2008) Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nature Immunology, 9(12), pp. 1356-1363. (doi:10.1038/ni.1670) (PMID:18931680) (PMCID:PMC2935464)

2007

Mahajan, S., Cervera, A., Macleod, M., Fillatreau, S., Perona-Wright, G., Meek, S., Smith, A., MacDonald, A. and Gray, D. (2007) The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells. European Journal of Immunology, 37(7), pp. 1796-1808. (doi:10.1002/eji.200636661) (PMID:17549732) (PMCID:PMC2699381)

2006

Oliver, P. M. et al. (2006) Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Immunity, 25(6), pp. 929-940. (doi:10.1016/j.immuni.2006.10.012) (PMID:17137798) (PMCID:PMC2955961)

Robertson, J. M., Macleod, M., Marsden, V. S., Kappler, J. W. and Marrack, P. (2006) Not all CD4+ memory T cells are long lived. Immunological Reviews, 211(1), pp. 58-66. (doi:10.1111/j.0105-2896.2006.00383.x) (PMID:16824116)

Macleod, M., Kwakkenbos, M. J., Crawford, A., Brown, S., Stockinger, B., Schepers, K., Schumacher, T. and Gray, D. (2006) CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40. Journal of Experimental Medicine, 203(4), pp. 897-906. (doi:10.1084/jem.20050711) (PMID:16549596) (PMCID:PMC2118277)

Crawford, A., Macleod, M., Schumacher, T., Corlett, L. and Gray, D. (2006) Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells. Journal of Immunology, 176(6), pp. 3498-3506. (doi:10.4049/jimmunol.176.6.3498) (PMID:16517718)

2003

Adams, C. L., Macleod, M. K.L., Milner-White, E. J., Aitken, R., Garside, P. and Stott, D.I. (2003) Complete analysis of the B-cell response to a protein antigen, from in vivo germinal centre formation to 3-D modelling of affinity maturation. Immunology, 108(3), pp. 274-287. (doi:10.1046/j.1365-2567.2003.01583.x) (PMID:12603593)

2002

Lee, G. K., Park, H. J., Macleod, M., Chandler, P., Munn, D. H. and Mellor, A. L. (2002) Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division. Immunology, 107(4), pp. 452-460. (doi:10.1046/j.1365-2567.2002.01526.x)

This list was generated on Thu Apr 19 16:33:32 2018 BST.
Number of items: 31.

Articles

Gray, J. I., Westerhof, L. M. and Macleod, M. K.L. (2018) The roles of resident, central and effector memory CD4 T cells in protective immunity following infection or vaccination. Immunology, (doi:10.1111/imm.12929) (PMID:29570776) (Early Online Publication)

Jaigrdar, S. A., Benson, R. A., Elmesmari, A., Kurowska-Stolarska, M. S. , McInnes, I. B. , Garside, P. and Macleod, M. K.L. (2017) Sphingosine-1-phosphate promotes the persistence of activated CD4 T cells in inflamed sites. Frontiers in Immunology, 8, 1627. (doi:10.3389/fimmu.2017.01627) (PMID:29225602) (PMCID:PMC5705559)

Jaigirdar, S. A. and Macleod, M. K.L. (2015) Development and function of protective and pathologic memory CD4 T cells. Frontiers in Immunology, 6, 456. (doi:10.3389/fimmu.2015.00456) (PMID:26441961) (PMCID:PMC4561815)

Macleod, M. K.L. and Anderton, S. M. (2015) Antigen-based immunotherapy (AIT) for autoimmune and allergic disease. Current Opinion in Pharmacology, 23, pp. 11-16. (doi:10.1016/j.coph.2015.05.003) (PMID:26004365)

Oliver-Bell, J., Butcher, J.P., Malcolm, J. , Macleod, M.K.L. , Adrados Planell, A., Campbell, L., Nibbs, R.J.B., Garside, P., McInnes, I.B. and Culshaw, S. (2015) Periodontitis in the absence of B cells and specific anti-bacterial antibody. Oral Microbiology and Immunology, 30(2), pp. 160-169. (doi:10.1111/omi.12082) (PMID:25219939)

Benson, R. A., Macleod, M. K.L., Hale, B. G.H. , Patakas, A., Garside, P. and Brewer, J. M. (2015) Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo. eLife, 4, e06994. (doi:10.7554/eLife.06994) (PMID:26258879) (PMCID:PMC4558563)

David, A., Trigunaite, A., Macleod, M. K., Johnson, A. C., Marrack, P. and Jørgensen, T. N. (2014) Intrinsic autoimmune capacities of hematopoietic cells from female New Zealand hybrid mice. Genes and Immunity, 15(3), pp. 153-161. (doi:10.1038/gene.2014.2) (PMID:24477163) (PMCID:PMC3999239)

David, A., Crawford, F., Garside, P., Kappler, J. W., Marrack, P. and Macleod, M. (2014) Tolerance induction in memory CD4 T cells requires two rounds of antigen-specific activation. Proceedings of the National Academy of Sciences of the United States of America, 111(21), pp. 7735-7740. (doi:10.1073/pnas.1406218111) (PMID:24821788) (PMCID:PMC4040609)

Huang, Y. et al. (2013) Antigen-specific regulation of IgE antibodies by non-antigen-specific T cells. Journal of Immunology, 190(3), pp. 913-921. (doi:10.4049/jimmunol.1202230)

Macleod, M.K.L., David, A., Jin, N., Noges, L., Wang, J., Kappler, J.W. and Marrack, P. (2013) Influenza nucleoprotein delivered with aluminium salts protects mice from an influenza virus that expresses an altered nucleoprotein sequence. PLoS ONE, 8(4), e61775. (doi:10.1371/journal.pone.0061775) (PMID:23613928) (PMCID:PMC3629017)

Aviszus, K., Macleod, M., Kirchenbaum, G.A., Detanico, D.O., Heiser, R.A., St. Clair, J.B., Guo, W.J. and Wysocki, L.J. (2012) Antigen specific suppression of humoral immunity by anergic Ars/A1 B cells. Journal of Immunology, 189(9), pp. 4275-4283.

MacLeod, M.K.L., David, A., McKee, A.S., Crawford, F., Kappler, J.W. and Marrack, P. (2011) Memory CD4 T cells that express CXCR5 provide accelerated help to B cells. Journal of Immunology, 186(5), pp. 2889-2896. (doi:10.4049/jimmunol.1002955)

MacLeod, M.K.L., McKee, A.S., David, A., Wang, J., Mason, R., Kappler, J.W. and Marrack, P. (2011) Vaccine adjuvants aluminum and monophosphoryl lipid A provide distinct signals to generate protective cytotoxic memory CD8 T cells. Proceedings of the National Academy of Sciences of the United States of America, 108(19), pp. 7914-7919. (doi:10.1073/pnas.1104588108)

MacLeod, M.K.L., Kappler, J.W. and Marrack, P. (2010) Memory CD4 T cells: generation, reactivation and re-assignment. Immunology, 130(1), pp. 10-15. (doi:10.1111/j.1365-2567.2010.03260.x)

Marrack, P., Scott-Browne, J. and MacLeod, M.K.L. (2010) Terminating the immune response. Immunological Reviews, 236(1), pp. 5-10. (doi:10.1111/j.1600-065X.2010.00928.x)

McKee, A.S., MacLeod, M.K.L., Kappler, J.W. and Marrack, P. (2010) Immune mechanisms of protection: can adjuvants rise to the challenge? BMC Biology, 8(1), p. 37. (doi:10.1186/1741-7007-8-37)

Munks, M.W., McKee, A.S., MacLeod, M.K.L., Powell, R.L., Degen, J.L., Reisdorph, N.A., Kappler, J.W. and Marrack, P. (2010) Aluminum adjuvants elicit fibrin-dependent extracellular traps in vivo. Blood, 116(24), pp. 5191-5199. (doi:10.1182/blood-2010-03-275529)

MacLeod, M.K.L., Clambey, E.T., Kappler, J.W. and Marrack, P. (2009) CD4 memory T cells: What are they and what can they do? Seminars in Immunology, 21(2), pp. 53-61. (doi:10.1016/j.smim.2009.02.006)

McKee, A.S., Munks, M.W., MacLeod, M.K.L., Fleenor, C.J., Van Rooijen, N., Kappler, J.W. and Marrack, P. (2009) Alum induces innate immune responses through macrophage and mast cell sensors, but these sensors are not required for alum to act as an adjuvant for specific immunity. Journal of Immunology, 183(7), pp. 4403-4414. (doi:10.4049/jimmunol.0900164)

Macleod, M. K. L., McKee, A., Crawford, F., White, J., Kappler, J. and Marrack, P. (2008) CD4 memory T cells divide poorly in response to antigen because of their cytokine profile. Proceedings of the National Academy of Sciences of the United States of America, 105(38), pp. 14521-14526. (doi:10.1073/pnas.0807449105) (PMID:18787120) (PMCID:PMC2533680)

McKee, A. S., Macleod, M., White, J., Crawford, F., Kappler, J. W. and Marrack, P. (2008) Gr1+IL-4-producing innate cells are induced in response to Th2 stimuli and suppress Th1-dependent antibody responses. International Immunology, 20(5), pp. 659-669. (doi:10.1093/intimm/dxn025) (PMID:18343889) (PMCID:PMC2935467)

Yang, B., Gay, D. L., Macleod, M. K.L., Cao, X., Hala, T., Sweezer, E. M., Kappler, J., Marrack, P. and Oliver, P. M. (2008) Nedd4 augments the adaptive immune response by promoting ubiquitin-mediated degradation of Cbl-b in activated T cells. Nature Immunology, 9(12), pp. 1356-1363. (doi:10.1038/ni.1670) (PMID:18931680) (PMCID:PMC2935464)

Mahajan, S., Cervera, A., Macleod, M., Fillatreau, S., Perona-Wright, G., Meek, S., Smith, A., MacDonald, A. and Gray, D. (2007) The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells. European Journal of Immunology, 37(7), pp. 1796-1808. (doi:10.1002/eji.200636661) (PMID:17549732) (PMCID:PMC2699381)

Oliver, P. M. et al. (2006) Ndfip1 protein promotes the function of itch ubiquitin ligase to prevent T cell activation and T helper 2 cell-mediated inflammation. Immunity, 25(6), pp. 929-940. (doi:10.1016/j.immuni.2006.10.012) (PMID:17137798) (PMCID:PMC2955961)

Robertson, J. M., Macleod, M., Marsden, V. S., Kappler, J. W. and Marrack, P. (2006) Not all CD4+ memory T cells are long lived. Immunological Reviews, 211(1), pp. 58-66. (doi:10.1111/j.0105-2896.2006.00383.x) (PMID:16824116)

Macleod, M., Kwakkenbos, M. J., Crawford, A., Brown, S., Stockinger, B., Schepers, K., Schumacher, T. and Gray, D. (2006) CD4 memory T cells survive and proliferate but fail to differentiate in the absence of CD40. Journal of Experimental Medicine, 203(4), pp. 897-906. (doi:10.1084/jem.20050711) (PMID:16549596) (PMCID:PMC2118277)

Crawford, A., Macleod, M., Schumacher, T., Corlett, L. and Gray, D. (2006) Primary T cell expansion and differentiation in vivo requires antigen presentation by B cells. Journal of Immunology, 176(6), pp. 3498-3506. (doi:10.4049/jimmunol.176.6.3498) (PMID:16517718)

Adams, C. L., Macleod, M. K.L., Milner-White, E. J., Aitken, R., Garside, P. and Stott, D.I. (2003) Complete analysis of the B-cell response to a protein antigen, from in vivo germinal centre formation to 3-D modelling of affinity maturation. Immunology, 108(3), pp. 274-287. (doi:10.1046/j.1365-2567.2003.01583.x) (PMID:12603593)

Lee, G. K., Park, H. J., Macleod, M., Chandler, P., Munn, D. H. and Mellor, A. L. (2002) Tryptophan deprivation sensitizes activated T cells to apoptosis prior to cell division. Immunology, 107(4), pp. 452-460. (doi:10.1046/j.1365-2567.2002.01526.x)

Book Sections

Benson, R. A., Lawton, J. C. and MacLeod, M. K.L. (2017) T cell response in the lung following influenza virus infection. In: Rainger, G. E. and Mcgettrick, H. M. (eds.) T-Cell Trafficking: Methods and Protocols. Series: Methods in molecular biology (1591). Springer: New York, pp. 235-248. ISBN 9781493969296 (doi:10.1007/978-1-4939-6931-9_17)

Bosio, C.M., Macleod, M., Marrack, P. and Kedl, R.M. (2012) Utility of mouse models in vaccine design and development. In: Morrow, W.J.W., Sheikh, N.A., Schmidt, C.S. and Davies, H. (eds.) Vaccinology: Principles and Practices. Wiley-Blackwell: Chichester, UK. ISBN 9781405185745 (doi:10.1002/9781118345313.ch7)

This list was generated on Thu Apr 19 16:33:32 2018 BST.