Professor Rick Maizels

  • Professor (Parasitology)

Biography

Professor Rick Maizels is at the Wellcome Trust Centre for Molecular Parasitology in the University of Glasgow's Institute of Infection, Immunity and Inflammation.  

Please go to the Maizels Lab Website for full information about our work.

Rick is an immunologist interested in fundamental questions of how and why parasites manipulate the sophisticated mammalian immune system, and how that system has evolved in the face of parasite immunomodulatory strategies. His laboratory focuses on the most complex parasites to invade the body – multicellular helminths –which cause widespread tropical diseases while displaying profound immuno-regulatory capability.  The central questions his group addresses are: (i) how do parasites manipulate the host immune system? (ii) what is the impact of this modulation on immunological diseases? and: (iii) what parasite molecules are responsible for immunomodulation? Rick moved to the University of Glasgow in 2016; between 1995 and 2015 he held the Chair of Zoology at the University of Edinburgh, and was previously Professor of Parasite Immunology at Imperial College London, where he moved in 1983. Prior to this, he held positions at the National Institute for Medical Research in London (1973-1976 and 1979-1983), as well as UCLA (1977-1979) and California Institute of Technology (1986-1977). He was elected Fellow of the Royal Society of Edinburgh in 2002, and made a Senior Fellow of the American Asthma Foundation in 2010.


Research interests

Please go to the Maizels Lab Website for full information about our work.

Summary

We aim to integrate detailed studies at the level of individual parasite molecules, with system-level immunology of suppressing inflammatory diseases and inducing protective immunity.  Our techniques combine molecular biology of parasite genes, protein function and structure, cellular immunology and host gene expression, and a range of pathology models representing allergy, autoimmunity and inflammatory bowel disease.

We study nematode parasites because they display remarkable biological properties and are tractable at a molecular and cellular level. For example, the filarial nematode is transmitted by mosquito and infects 120 million people in developing countries. Parasites can live for 5 years or more, acting as successful tissue transplants. If we can analyse how they achieve this feat, we may discover important new pathways to control both parasites and the immune system.

In particular, we are now testing the hypothesis that helminth parasites exploit the body's own safety mechanisms which have evolved to minimise the risk of autoimmunity. For example, regulatory T cells naturally arise to limit autoreactivity, but are also associated with chronic helminth infection. The expansion of regulatory T cell populations may underlie the epidemiological association between infection and reduced levels of allergy.

 

 


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Asthma Prevention consortium
    The Netherlands Lung Foundation
    2018 - 2019
     
  • Helminths and the Immune System: Regulation, Regulators and Immunity
    Wellcome Trust
    2016 - 2020
     
  • Induction of Therapeutic Regulatory T cells by Parasite Products
    The Kenneth Rainin Foundation
    2015 - 2018
     

Teaching

More information at the Maizels Lab Website


Supervision

Publications

List by: Type | Date

Jump to: 2018 | 2017 | 2016 | 2015 | 2014 | 2009
Number of items: 37.

2018

International Helminth Genomes Consortium, et al. (2018) Comparative genomics of the major parasitic worms. Nature Genetics, (doi:10.1038/s41588-018-0262-1) (PMID:30397333) (Early Online Publication)

Robertson, E., Harcus, Y., Johnston, C. J.C., Page, A. P. , Walkinshaw, M. D., Maizels, R. M. and Houston, D. (2018) Demonstration of the anthelmintic potency of marimastat in the Heligmosomoides polygyrus rodent model. Journal of Parasitology, (doi:10.1645/18-33) (PMID:30085900) (In Press)

Alimi, D., Abidi, A., Sebai, E., Rekik, M., Maizels, R.M. , Dhibi, M. and Akkari, H. (2018) In vivo nematicidal potential of camel milk on Heligmosomoides polygyrus gastro-intestinal nematode of rodents. Helminthologia, 55(2), pp. 112-118. (doi:10.2478/helm-2018-0001)

Asojo, O. A., Darwiche, R., Gebremedhin, S., Smant, G., Lozano-Torres, J. L., Drurey, C., Pollet, J., Maizels, R. M. , Schneiter, R. and Wilbers, R. H.P. (2018) Heligmosomoides polygyrus venom allergen-like protein-4 (HpVAL-4) is a sterol binding protein. International Journal for Parasitology, 48(5), pp. 359-369. (doi:10.1016/j.ijpara.2018.01.002) (PMID:29505764) (PMCID:PMC5893428)

Darwiche, R., Lugo, F., Drurey, C., Varossieau, K., Smant, G., Wilbers, R. H.P., Maizels, R. M. , Schneiter, R. and Asojo, O. A. (2018) Crystal structure of Brugia malayi venom allergen-like protein-1 (BmVAL-1), a vaccine candidate for lymphatic filariasis. International Journal for Parasitology, 48(5), pp. 371-378. (doi:10.1016/j.ijpara.2017.12.003) (PMID:29501266)

Selkirk, M. E., Davis, R. E., Gounaris, K. and Maizels, R. M. (2018) Special issue: molecular and cellular biology of helminth parasites XI. International Journal for Parasitology, 48(5), pp. 319-320. (doi:10.1016/j.ijpara.2018.03.001) (PMID:29631700)

Smyth, D. J. et al. (2018) TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus. International Journal for Parasitology, 48(5), pp. 379-385. (doi:10.1016/j.ijpara.2017.12.004) (PMID:29510118) (PMCID:PMC5904571)

Löser, S. and Maizels, R. M. (2018) Immunology: the neuronal pathway to mucosal immunity. Current Biology, 28(1), R33-R36. (doi:10.1016/j.cub.2017.11.025) (PMID:29316420)

Ma, G., Holland, C. V., Wang, T., Hofmann, A., Fan, C.-K., Maizels, R. M. , Hotez, P. J. and Gasser, R. B. (2018) Human toxocariasis. Lancet Infectious Diseases, 18(1), e14-e24. (doi:10.1016/S1473-3099(17)30331-6) (PMID:28781085)

Maizels, R. , Smits, H. H. and McSorley, H. J. (2018) Modulation of host immunity by helminths: the expanding repertoire of parasite effector molecules. Immunity, (Accepted for Publication)

2017

Johnston, C. J.C. et al. (2017) A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells. Nature Communications, 8, 1741. (doi:10.1038/s41467-017-01886-6) (PMID:29170498) (PMCID:PMC5701006)

Osbourn, M. et al. (2017) HpARI protein secreted by a helminth parasite suppresses interleukin-33. Immunity, 47(4), 739-751.e5. (doi:10.1016/j.immuni.2017.09.015) (PMID:29045903) (PMCID:PMC5655542)

Pastille, E. et al. (2017) Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer. PLoS Pathogens, 13(9), e1006649. (doi:10.1371/journal.ppat.1006649) (PMID:28938014) (PMCID:PMC5627963)

Varyani, F., Fleming, J. O. and Maizels, R. (2017) Helminths in the gastrointestinal tract 1 as modulators of immunity and pathology. American Journal of Physiology: Gastrointestinal and Liver Physiology, 312(6), G537-G549. (doi:10.1152/ajpgi.00024.2017) (PMID:28302598) (PMCID:5495915)

Coakley, G., McCaskill, J. L., Borger, J. G., Simbari, F., Robertson, E., Millar, M., Harcus, Y., McSorley, H. J., Maizels, R. M. and Buck, A. H. (2017) Extracellular vesicles from a helminth parasite suppress macrophage activation and constitute an effective vaccine for protective immunity. Cell Reports, 19(8), pp. 1545-1557. (doi:10.1016/j.celrep.2017.05.001) (PMID:28538175) (PMCID:PMC5457486)

Rückerl, D., Campbell, S. M., Duncan, S., Sutherland, T. E., Jenkins, S. J., Hewitson, J. P., Barr, T. A., Jackson-Jones, L. H. and Maizels, R. M. (2017) Macrophage origin limits functional plasticity in helminth-bacterial co-infection. PLoS Pathogens, 13(3), e1006233. (doi:10.1371/journal.ppat.1006233) (PMID:28334040) (PMCID:PMC5364000)

Mutapi, F., Maizels, R. , Fenwick, A. and Woolhouse, M. (2017) Human schistosomiasis in the post Mass Drug Administration (MDA) era. Lancet Infectious Diseases, 17(2), e42-e48. (doi:10.1016/S1473-3099(16)30475-3) (PMID:27988094)

Maizels, R. M. and Hewiston, J. P. (2017) Myeloid cell phenotypes in susceptibility and resistance to parasitic infections. In: Gordon, S. (ed.) Myeloid Cells in Health and Disease: a Synthesis. ASM Press: Washington, DC, pp. 759-769. ISBN 9781555819187 (doi:10.1128/microbiolspec.MCHD-0043-2016)

2016

Jackson-Jones, L. H. et al. (2016) IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha. European Journal of Immunology, 46(10), pp. 2311-2321. (doi:10.1002/eji.201646442) (PMID:27592711)

Jackson-Jones, L. H., Duncan, S. M., Magalhaes, M. S., Campbell, S. M., Maizels, R. M. , McSorley, H. J., Allen, J. E. and Bénézech, C. (2016) Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation. Nature Communications, 7, 12651. (doi:10.1038/ncomms12651) (PMID:27582256) (PMCID:PMC5025788)

Maizels, R. M. and McSorley, H. (2016) Regulation of the host immune system by helminth parasites. Journal of Allergy and Clinical Immunology, 138(3), pp. 666-675. (doi:10.1016/j.jaci.2016.07.007) (PMID:27476889) (PMCID:PMC5010150)

Gause, W. C. and Maizels, R. M. (2016) Macrobiota — helminths as active participants and partners of the microbiota in host intestinal homeostasis. Current Opinion in Microbiology, 32, pp. 14-18. (doi:10.1016/j.mib.2016.04.004) (PMID:27116368) (PMCID:PMC4983462)

Coakley, G., Buck, A. H. and Maizels, R. M. (2016) Host parasite communications—Messages from helminths for the immune system: parasite communication and cell-cell interactions. Molecular and Biochemical Parasitology, 208(1), pp. 33-40. (doi:10.1016/j.molbiopara.2016.06.003) (PMID:27297184)

Simbari, F., McCaskill, J., Coakley, G., Millar, M., Maizels, R. M. , Fabriás, G., Casas, J. and Buck, A. H. (2016) Plasmalogen enrichment in exosomes secreted by a nematode parasite versus those derived from its mouse host: implications for exosome stability and biology. Journal of Extracellular Vesicles, 5, 30741. (doi:10.3402/jev.v5.30741) (PMID:27389011) (PMCID:PMC4937767)

Maizels, R.M. (2016) Parasitic helminth infections and the control of human allergic and autoimmune disorders. Clinical Microbiology and Infection, 22(6), pp. 481-486. (doi:10.1016/j.cmi.2016.04.024) (PMID:27172808)

Lundie, R. J. et al. (2016) A central role for hepatic conventional dendritic cells in supporting Th2 responses during helminth infection. Immunology and Cell Biology, 94(4), pp. 400-410. (doi:10.1038/icb.2015.114) (PMID:26657145) (PMCID:PMC4817239)

Obieglo, K. et al. (2016) Chronic gastrointestinal nematode infection mutes immune responses to mycobacterial infection distal to the gut. Journal of Immunology, 196(5), pp. 2262-2271. (doi:10.4049/​jimmunol.1500970) (PMID:26819205) (PMCID:PMC4760231)

Duffin, R. et al. (2016) Prostaglandin E2 constrains systemic inflammation through an innate lymphoid cell-IL-22 axis. Science, 351(6279), pp. 1333-1338. (doi:10.1126/science.aad9903) (PMID:26989254)

Hewitson, J. P., Nguyen, D. L., van Diepen, A., Smit, C. H., Koeleman, C. A., McSorley, H. J., Murray, J., Maizels, R. M. and Hokke, C. H. (2016) Novel O-linked methylated glycan antigens decorate secreted immunodominant glycoproteins from the intestinal nematode Heligmosomoides polygyrus. International Journal for Parasitology, 46(3), pp. 157-170. (doi:10.1016/j.ijpara.2015.10.004) (PMID:26688390) (PMCID:PMC4776704)

Smith, K.A., Filbey, K.J., Reynolds, L.A., Hewitson, J.P., Harcus, Y., Boon, L., Sparwasser, T., Hämmerling, G. and Maizels, R.M. (2016) Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths. Mucosal Immunology, 9(2), pp. 428-443. (doi:10.1038/mi.2015.73) (PMID:26286232) (PMCID:PMC4677460)

Smits, H. H. et al. (2016) Microbes and asthma: opportunities for intervention. Journal of Allergy and Clinical Immunology, 137(3), pp. 690-697. (doi:10.1016/j.jaci.2016.01.004) (PMID:26947981)

Gerbe, F. et al. (2016) Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites. Nature, 529(7585), pp. 226-230. (doi:10.1038/nature16527) (PMID:26762460)

Johnston, C. J.C., Smyth, D. J. , Dresser, D. W. and Maizels, R. M. (2016) TGF-β in tolerance, development and regulation of immunity. Cellular Immunology, 299, pp. 14-22. (doi:10.1016/j.cellimm.2015.10.006) (PMID:26617281) (PMCID:PMC4711336)

Maizels, R. M. (2016) Regulatory T-cell control of type 2 inflammation. In: Gause, W. C. and Artis, D. (eds.) The Th2 Type Immune Response in Health and Disease: From Host Defense and Allergy to Metabolic Homeostasis and Beyond. Springer: New York, pp. 73-95. ISBN 9781493929108 (doi:10.1007/978-1-4939-2911-5_5)

2015

Johnston, C. J.C., Robertson, E., Harcus, Y., Grainger, J. R., Coakley, G., Smyth, D. J. , McSorley, H. J. and Maizels, R. (2015) Cultivation of Heligmosomoides polygyrus: an immunomodulatory nematode parasite and its secreted products. Journal of Visualized Experiments(98), e52412. (doi:10.3791/52412) (PMID:25867600) (PMCID:PMC4401400)

2014

Maizels, R.M. , McSorley, H.J. and Smyth, D.J. (2014) Helminths in the hygiene hypothesis: sooner or later? Clinical and Experimental Immunology, 177(1), pp. 38-46. (doi:10.1111/cei.12353) (PMID:24749722) (PMCID:PMC4089153)

2009

Perona-Wright, G., Jenkins, S. J., O'Connor, R. A., Zienkiewicz, D., McSorley, H. J., Maizels, R. M. , Anderton, S. M. and MacDonald, A. S. (2009) A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo. Journal of Immunology, 182(5), pp. 2808-2815. (doi:10.4049/jimmunol.0803553) (PMID:19234175)

This list was generated on Sun Dec 16 21:07:03 2018 GMT.
Number of items: 37.

Articles

International Helminth Genomes Consortium, et al. (2018) Comparative genomics of the major parasitic worms. Nature Genetics, (doi:10.1038/s41588-018-0262-1) (PMID:30397333) (Early Online Publication)

Robertson, E., Harcus, Y., Johnston, C. J.C., Page, A. P. , Walkinshaw, M. D., Maizels, R. M. and Houston, D. (2018) Demonstration of the anthelmintic potency of marimastat in the Heligmosomoides polygyrus rodent model. Journal of Parasitology, (doi:10.1645/18-33) (PMID:30085900) (In Press)

Alimi, D., Abidi, A., Sebai, E., Rekik, M., Maizels, R.M. , Dhibi, M. and Akkari, H. (2018) In vivo nematicidal potential of camel milk on Heligmosomoides polygyrus gastro-intestinal nematode of rodents. Helminthologia, 55(2), pp. 112-118. (doi:10.2478/helm-2018-0001)

Asojo, O. A., Darwiche, R., Gebremedhin, S., Smant, G., Lozano-Torres, J. L., Drurey, C., Pollet, J., Maizels, R. M. , Schneiter, R. and Wilbers, R. H.P. (2018) Heligmosomoides polygyrus venom allergen-like protein-4 (HpVAL-4) is a sterol binding protein. International Journal for Parasitology, 48(5), pp. 359-369. (doi:10.1016/j.ijpara.2018.01.002) (PMID:29505764) (PMCID:PMC5893428)

Darwiche, R., Lugo, F., Drurey, C., Varossieau, K., Smant, G., Wilbers, R. H.P., Maizels, R. M. , Schneiter, R. and Asojo, O. A. (2018) Crystal structure of Brugia malayi venom allergen-like protein-1 (BmVAL-1), a vaccine candidate for lymphatic filariasis. International Journal for Parasitology, 48(5), pp. 371-378. (doi:10.1016/j.ijpara.2017.12.003) (PMID:29501266)

Selkirk, M. E., Davis, R. E., Gounaris, K. and Maizels, R. M. (2018) Special issue: molecular and cellular biology of helminth parasites XI. International Journal for Parasitology, 48(5), pp. 319-320. (doi:10.1016/j.ijpara.2018.03.001) (PMID:29631700)

Smyth, D. J. et al. (2018) TGF-β mimic proteins form an extended gene family in the murine parasite Heligmosomoides polygyrus. International Journal for Parasitology, 48(5), pp. 379-385. (doi:10.1016/j.ijpara.2017.12.004) (PMID:29510118) (PMCID:PMC5904571)

Löser, S. and Maizels, R. M. (2018) Immunology: the neuronal pathway to mucosal immunity. Current Biology, 28(1), R33-R36. (doi:10.1016/j.cub.2017.11.025) (PMID:29316420)

Ma, G., Holland, C. V., Wang, T., Hofmann, A., Fan, C.-K., Maizels, R. M. , Hotez, P. J. and Gasser, R. B. (2018) Human toxocariasis. Lancet Infectious Diseases, 18(1), e14-e24. (doi:10.1016/S1473-3099(17)30331-6) (PMID:28781085)

Maizels, R. , Smits, H. H. and McSorley, H. J. (2018) Modulation of host immunity by helminths: the expanding repertoire of parasite effector molecules. Immunity, (Accepted for Publication)

Johnston, C. J.C. et al. (2017) A structurally distinct TGF-β mimic from an intestinal helminth parasite potently induces regulatory T cells. Nature Communications, 8, 1741. (doi:10.1038/s41467-017-01886-6) (PMID:29170498) (PMCID:PMC5701006)

Osbourn, M. et al. (2017) HpARI protein secreted by a helminth parasite suppresses interleukin-33. Immunity, 47(4), 739-751.e5. (doi:10.1016/j.immuni.2017.09.015) (PMID:29045903) (PMCID:PMC5655542)

Pastille, E. et al. (2017) Intestinal helminth infection drives carcinogenesis in colitis-associated colon cancer. PLoS Pathogens, 13(9), e1006649. (doi:10.1371/journal.ppat.1006649) (PMID:28938014) (PMCID:PMC5627963)

Varyani, F., Fleming, J. O. and Maizels, R. (2017) Helminths in the gastrointestinal tract 1 as modulators of immunity and pathology. American Journal of Physiology: Gastrointestinal and Liver Physiology, 312(6), G537-G549. (doi:10.1152/ajpgi.00024.2017) (PMID:28302598) (PMCID:5495915)

Coakley, G., McCaskill, J. L., Borger, J. G., Simbari, F., Robertson, E., Millar, M., Harcus, Y., McSorley, H. J., Maizels, R. M. and Buck, A. H. (2017) Extracellular vesicles from a helminth parasite suppress macrophage activation and constitute an effective vaccine for protective immunity. Cell Reports, 19(8), pp. 1545-1557. (doi:10.1016/j.celrep.2017.05.001) (PMID:28538175) (PMCID:PMC5457486)

Rückerl, D., Campbell, S. M., Duncan, S., Sutherland, T. E., Jenkins, S. J., Hewitson, J. P., Barr, T. A., Jackson-Jones, L. H. and Maizels, R. M. (2017) Macrophage origin limits functional plasticity in helminth-bacterial co-infection. PLoS Pathogens, 13(3), e1006233. (doi:10.1371/journal.ppat.1006233) (PMID:28334040) (PMCID:PMC5364000)

Mutapi, F., Maizels, R. , Fenwick, A. and Woolhouse, M. (2017) Human schistosomiasis in the post Mass Drug Administration (MDA) era. Lancet Infectious Diseases, 17(2), e42-e48. (doi:10.1016/S1473-3099(16)30475-3) (PMID:27988094)

Jackson-Jones, L. H. et al. (2016) IL-33 delivery induces serous cavity macrophage proliferation independent of interleukin-4 receptor alpha. European Journal of Immunology, 46(10), pp. 2311-2321. (doi:10.1002/eji.201646442) (PMID:27592711)

Jackson-Jones, L. H., Duncan, S. M., Magalhaes, M. S., Campbell, S. M., Maizels, R. M. , McSorley, H. J., Allen, J. E. and Bénézech, C. (2016) Fat-associated lymphoid clusters control local IgM secretion during pleural infection and lung inflammation. Nature Communications, 7, 12651. (doi:10.1038/ncomms12651) (PMID:27582256) (PMCID:PMC5025788)

Maizels, R. M. and McSorley, H. (2016) Regulation of the host immune system by helminth parasites. Journal of Allergy and Clinical Immunology, 138(3), pp. 666-675. (doi:10.1016/j.jaci.2016.07.007) (PMID:27476889) (PMCID:PMC5010150)

Gause, W. C. and Maizels, R. M. (2016) Macrobiota — helminths as active participants and partners of the microbiota in host intestinal homeostasis. Current Opinion in Microbiology, 32, pp. 14-18. (doi:10.1016/j.mib.2016.04.004) (PMID:27116368) (PMCID:PMC4983462)

Coakley, G., Buck, A. H. and Maizels, R. M. (2016) Host parasite communications—Messages from helminths for the immune system: parasite communication and cell-cell interactions. Molecular and Biochemical Parasitology, 208(1), pp. 33-40. (doi:10.1016/j.molbiopara.2016.06.003) (PMID:27297184)

Simbari, F., McCaskill, J., Coakley, G., Millar, M., Maizels, R. M. , Fabriás, G., Casas, J. and Buck, A. H. (2016) Plasmalogen enrichment in exosomes secreted by a nematode parasite versus those derived from its mouse host: implications for exosome stability and biology. Journal of Extracellular Vesicles, 5, 30741. (doi:10.3402/jev.v5.30741) (PMID:27389011) (PMCID:PMC4937767)

Maizels, R.M. (2016) Parasitic helminth infections and the control of human allergic and autoimmune disorders. Clinical Microbiology and Infection, 22(6), pp. 481-486. (doi:10.1016/j.cmi.2016.04.024) (PMID:27172808)

Lundie, R. J. et al. (2016) A central role for hepatic conventional dendritic cells in supporting Th2 responses during helminth infection. Immunology and Cell Biology, 94(4), pp. 400-410. (doi:10.1038/icb.2015.114) (PMID:26657145) (PMCID:PMC4817239)

Obieglo, K. et al. (2016) Chronic gastrointestinal nematode infection mutes immune responses to mycobacterial infection distal to the gut. Journal of Immunology, 196(5), pp. 2262-2271. (doi:10.4049/​jimmunol.1500970) (PMID:26819205) (PMCID:PMC4760231)

Duffin, R. et al. (2016) Prostaglandin E2 constrains systemic inflammation through an innate lymphoid cell-IL-22 axis. Science, 351(6279), pp. 1333-1338. (doi:10.1126/science.aad9903) (PMID:26989254)

Hewitson, J. P., Nguyen, D. L., van Diepen, A., Smit, C. H., Koeleman, C. A., McSorley, H. J., Murray, J., Maizels, R. M. and Hokke, C. H. (2016) Novel O-linked methylated glycan antigens decorate secreted immunodominant glycoproteins from the intestinal nematode Heligmosomoides polygyrus. International Journal for Parasitology, 46(3), pp. 157-170. (doi:10.1016/j.ijpara.2015.10.004) (PMID:26688390) (PMCID:PMC4776704)

Smith, K.A., Filbey, K.J., Reynolds, L.A., Hewitson, J.P., Harcus, Y., Boon, L., Sparwasser, T., Hämmerling, G. and Maizels, R.M. (2016) Low-level regulatory T-cell activity is essential for functional type-2 effector immunity to expel gastrointestinal helminths. Mucosal Immunology, 9(2), pp. 428-443. (doi:10.1038/mi.2015.73) (PMID:26286232) (PMCID:PMC4677460)

Smits, H. H. et al. (2016) Microbes and asthma: opportunities for intervention. Journal of Allergy and Clinical Immunology, 137(3), pp. 690-697. (doi:10.1016/j.jaci.2016.01.004) (PMID:26947981)

Gerbe, F. et al. (2016) Intestinal epithelial tuft cells initiate type 2 mucosal immunity to helminth parasites. Nature, 529(7585), pp. 226-230. (doi:10.1038/nature16527) (PMID:26762460)

Johnston, C. J.C., Smyth, D. J. , Dresser, D. W. and Maizels, R. M. (2016) TGF-β in tolerance, development and regulation of immunity. Cellular Immunology, 299, pp. 14-22. (doi:10.1016/j.cellimm.2015.10.006) (PMID:26617281) (PMCID:PMC4711336)

Johnston, C. J.C., Robertson, E., Harcus, Y., Grainger, J. R., Coakley, G., Smyth, D. J. , McSorley, H. J. and Maizels, R. (2015) Cultivation of Heligmosomoides polygyrus: an immunomodulatory nematode parasite and its secreted products. Journal of Visualized Experiments(98), e52412. (doi:10.3791/52412) (PMID:25867600) (PMCID:PMC4401400)

Maizels, R.M. , McSorley, H.J. and Smyth, D.J. (2014) Helminths in the hygiene hypothesis: sooner or later? Clinical and Experimental Immunology, 177(1), pp. 38-46. (doi:10.1111/cei.12353) (PMID:24749722) (PMCID:PMC4089153)

Perona-Wright, G., Jenkins, S. J., O'Connor, R. A., Zienkiewicz, D., McSorley, H. J., Maizels, R. M. , Anderton, S. M. and MacDonald, A. S. (2009) A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo. Journal of Immunology, 182(5), pp. 2808-2815. (doi:10.4049/jimmunol.0803553) (PMID:19234175)

Book Sections

Maizels, R. M. and Hewiston, J. P. (2017) Myeloid cell phenotypes in susceptibility and resistance to parasitic infections. In: Gordon, S. (ed.) Myeloid Cells in Health and Disease: a Synthesis. ASM Press: Washington, DC, pp. 759-769. ISBN 9781555819187 (doi:10.1128/microbiolspec.MCHD-0043-2016)

Maizels, R. M. (2016) Regulatory T-cell control of type 2 inflammation. In: Gause, W. C. and Artis, D. (eds.) The Th2 Type Immune Response in Health and Disease: From Host Defense and Allergy to Metabolic Homeostasis and Beyond. Springer: New York, pp. 73-95. ISBN 9781493929108 (doi:10.1007/978-1-4939-2911-5_5)

This list was generated on Sun Dec 16 21:07:03 2018 GMT.


Group Members

Group Members

Nicola Britton

Claire Drurey

Ran He

Stephan Loeser

Caitlin McManus

Danielle Smyth

Fumi Varyani

Madeleine White

Xuhang Wu

Public Engagement

Public Engagement

Some examples of recent activities discussing our research in public and in the media are given below;

Edinburgh Science Festival, March 2016 

Kenneth Rainin Foundation Annual Innovations Symposium
The Kenneth Rainin Foundation supports cutting edge research projects that work on diagnosing, treating and curing Inflammatory Bowl Disease.
In San Francisco in July 2015 Rick Maizels, a Foundation Grantee, spoke at the annual symposium that brings together Influential and Collaborative researchers and Innovative and Creative thinkers to work towards the common goal of curing IBD.
Please click on the link below to see a short video from scientists and researchers, including Rick, on why they attend the annual event:
 

BBC Radio Cambridge 'Naked Scientists' radio programme, 8 March 2015 -
Rick Maizels talked about 'Parasites tricking the immune system' (click to listen)
Henry McSorley talked about 'Therapeutic Parasites' (click to listen)

The Academy of Medical Sciences, March 2015 - Chris Johnston talked to Quentin about his Helminth research within the Maizels group. Click here to listen.

Cheltenham Science Festival, 8 June 2013 - sold out session on 'Is my immune system normal' (see link to website)  http://www.cheltenhamfestivals.com/science/whats-on/2013/is-my-immune-system-normal/  or download the flyer here

British Council article, 28 June 2012, Anti Allergy Parasite (download)

Wellcome Trust News, 1 September 2011, Out of Africa: what is an allergen?

Daily Mail article, July 2011. (download)

Interview with "the Naked Scientist" BBC, May 2011; click link on website to hear podcast.

Der Spiegel October 2010 in English or Deutsch

Guardian article on helminths, May 2010. (download)