Dr Georgia Perona-Wright

Honorary Senior Lecturer (School of Infection & Immunity)

email: Georgia.Perona-Wright@glasgow.ac.uk

School of Infection & Immunity, Sir Graeme Davies Building, Room B3/16, Level 3, 120 University Place, G12 8TA

Research interests

Immune responses can be both protective and pathological. The best response to an infection is one that is strong enough to clear the pathogen, but not so strong that it also damages the host. Our aim is to understand how the balance between these two outcomes is achieved. I am especially interested in the interaction between coincident, opposing cytokines:

What dictates the appropriate polarisation of an immune response to infection?
Do these instructions affect bystander cells, not specific for the original pathogen?
How does cytokine cross-talk affect the immune response during co-infection, when multiple pathogens strike at once? Can the cytokine network be manipulated for therapeutic gain?

For more detail, have a look at our lab website.

Publications

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Number of items: 38.

2023

Sinton, M. C. et al. (2023) IL-17 signalling is critical for controlling subcutaneous adipose tissue dynamics and parasite burden during chronic murine Trypanosoma brucei infection. Nature Communications, 14, 7070. (doi: 10.1038/s41467-023-42918-8) (PMID:37923768) (PMCID:PMC10624677)

Bennet, C. L. and Perona-Wright, G. (2023) Metabolic adaption of mucosal macrophages: is metabolism a driver of persistence across tissues? Mucosal Immunology, 16(5), pp. 753-763. (doi: 10.1016/j.mucimm.2023.06.006) (PMID:37385586) (PMCID:PMC10564628)

Pirillo, C. et al. (2023) Cotransfer of antigen and contextual information harmonizes peripheral and lymph node conventional dendritic cell activation. Science Immunology, 8(85), eadg8249. (doi: 10.1126/sciimmunol.adg8249) (PMID:37478193)

2022

Perona-Wright, G. and McSorley, H. J. (2022) Lessons from helminths: what worms have taught us about mucosal immunology. Mucosal Immunology, 15(6), pp. 1049-1051. (doi: 10.1038/s41385-022-00560-5) (PMID:35999461)

Webster, H. C., Gamino, V., Andrusaite, A. T., Ridgewell, O., McCowan, J., Shergold, A. L., Heieis, G. A., Milling, S. W.F. , Maizels, R. M. and Perona-Wright, G. (2022) Tissue-based IL-10 signalling in helminth infection limits IFNγ expression and promotes the intestinal Th2 response. Mucosal Immunology, 15(6), pp. 1257-1269. (doi: 10.1038/s41385-022-00513-y) (PMID:35428872) (PMCID:PMC9705258)

2021

Louwe, P. A., Badiola Gomez, L., Webster, H., Perona-Wright, G. , Bain, C. C., Forbes, S. J. and Jenkins, S. J. (2021) Recruited macrophages that colonize the post-inflammatory peritoneal niche convert into functionally divergent resident cells. Nature Communications, 12, 1770. (doi: 10.1038/s41467-021-21778-0) (PMID:33741914) (PMCID:PMC7979918)

Amiel, E. and Perona-Wright, G. (2021) Sweet talk: metabolic conversations between host and microbe during infection. Immunology, 162(2), pp. 121-122. (doi: 10.1111/imm.13301) (PMID:33443308) (PMCID:PMC7808147)

2020

Amiel, E. and Perona-Wright, G. (2020) Metabolic mediators: how immunometabolism directs the immune response to infection. Immunology, 161(3), pp. 163-164. (doi: 10.1111/imm.13275) (PMID:33085098) (PMCID:PMC7576874)

Vacca, F. et al. (2020) A helminth-derived suppressor of ST2 blocks allergic responses. eLife, 9, e54017. (doi: 10.7554/elife.54017) (PMID:32420871) (PMCID:PMC7234810)

Webster, H., Andrusaite, A., Shergold, A., Milling, S. and Perona-Wright, G. (2020) Isolation and functional characterisation of lamina propria leukocytes from helminth-infected, murine small intestine. Journal of Immunological Methods, 477, 112702. (doi: 10.1016/j.jim.2019.112702) (PMID:31705860) (PMCID:PMC6983935)

2018

Redpath, S. A., Heieis, G. A., Reynolds, L. A., Fonseca, N. M., Kim, S. S.-Y. and Perona-Wright, G. (2018) Functional specialization of intestinal dendritic cell subsets during Th2 helminth infection in mice. European Journal of Immunology, 48(1), pp. 87-98. (doi: 10.1002/eji.201747073) (PMID:28960280)

2017

Lo, B. C. et al. (2017) Loss of vascular CD34 results in increased sensitivity to lung injury. American Journal of Respiratory Cell and Molecular Biology, 57(6), pp. 651-661. (doi: 10.1165/rcmb.2016-0386OC) (PMID:28683207)

Reynolds, L. A. et al. (2017) Enteric helminths promote Salmonella co-infection by altering the intestinal metabolome. Journal of Infectious Diseases, 215(8), pp. 1245-1254. (doi: 10.1093/infdis/jix141) (PMID:28368463)

Scheer, S. et al. (2017) Early-life antibiotic treatment enhances the pathogenicity of CD4 + T cells during intestinal inflammation. Journal of Leukocyte Biology, 101(4), pp. 893-900. (doi: 10.1189/jlb.3MA0716-334RR) (PMID:28034915)

2016

Oudhoff, M. J., Antignano, F., Chenery, A. L., Burrows, K., Redpath, S. A., Braam, M. J., Perona-Wright, G. and Zaph, C. (2016) Intestinal epithelial cell-intrinsic deletion of Setd7 identifies role for developmental pathways in immunity to helminth infection. PLoS Pathogens, 12(9), e1005876. e1005876. (doi: 10.1371/journal.ppat.1005876) (PMID:27598373) (PMCID:PMC5012677)

Chenery, A. L., Antignano, F., Burrows, K., Scheer, S., Perona-Wright, G. and Zaph, C. (2016) Low-dose intestinal Trichuris muris infection alters the lung immune microenvironment and can suppress allergic airway inflammation. Infection and Immunity, 84(2), pp. 491-501. (doi: 10.1128/IAI.01240-15) (PMID:26644379) (PMCID:PMC4730564)

2015

Redpath, S. A., Heieis, G. and Perona-Wright, G. (2015) Spatial regulation of IL-4 signalling in vivo. Cytokine, 75(1), pp. 51-56. (doi: 10.1016/j.cyto.2015.02.026) (PMID:25819429)

Russell, S. L. et al. (2015) Perinatal antibiotic-induced shifts in gut microbiota have differential effects on inflammatory lung diseases. Journal of Allergy and Clinical Immunology, 135(1), 100-109.e5. (doi: 10.1016/j.jaci.2014.06.027) (PMID:25145536)

2014

Redpath, S.A., Fonseca, N.M. and Perona-Wright, G. (2014) Protection and pathology during parasite infection: IL-10 strikes the balance. Parasite Immunology, 36(6), pp. 233-252. (doi: 10.1111/pim.12113) (PMID:24666543)

Patton, D. T., Plumb, A. W., Redpath, S. A., Osborne, L. C., Perona-Wright, G. and Abraham, N. (2014) The development and survival but not function of follicular B cells is dependent on IL-7Rα Tyr449 signaling. PLoS ONE, 9(2), e88771. (doi: 10.1371/journal.pone.0088771) (PMID:24551160) (PMCID:PMC3923819)

2012

Perona-Wright, G. , Kohlmeier, J. E., Bassity, E., Freitas, T. C., Mohrs, K., Cookenham, T., Situ, H., Pearce, E. J., Woodland, D. L. and Mohrs, M. (2012) Persistent loss of IL-27 responsiveness in CD8+ memory T cells abrogates IL-10 expression in a recall response. Proceedings of the National Academy of Sciences of the United States of America, 109(45), pp. 18535-18540. (doi: 10.1073/pnas.1119133109) (PMID:23091017) (PMCID:PMC3494933)

Perona-Wright, G. , Lundie, R. J., Jenkins, S. J., Webb, L. M., Grencis, R. K. and MacDonald, A. S. (2012) Concurrent bacterial stimulation alters the function of helminth-activated dendritic cells, resulting in IL-17 induction. Journal of Immunology, 188(5), pp. 2350-2358. (doi: 10.4049/jimmunol.1101642) (PMID:22287718) (PMCID:PMC3378507)

2011

Kohlmeier, J. E. et al. (2011) Inflammatory chemokine receptors regulate CD8+T cell contraction and memory generation following infection. Journal of Experimental Medicine, 208(8), pp. 1621-1634. (doi: 10.1084/jem.20102110) (PMID:21788409) (PMCID:PMC3149221)

2010

Perona-Wright, G. , Mohrs, K. and Mohrs, M. (2010) Sustained signaling by canonical helper T cell cytokines throughout the reactive lymph node. Nature Immunology, 11(6), pp. 520-526. (doi: 10.1038/ni.1866) (PMID:20418876) (PMCID:PMC2895995)

Perona-Wright, G. , Mohrs, K., Mayer, K. D. and Mohrs, M. (2010) Differential regulation of IL-4R expression by antigen versus cytokine stimulation characterizes Th2 progression in vivo. Journal of Immunology, 184(2), pp. 615-623. (doi: 10.4049/jimmunol.0902408) (PMID:20018622) (PMCID:PMC3066071)

2009

Perona-Wright, G. , Mohrs, K., Szaba, F. M., Kummer, L. W., Madan, R., Karp, C. L., Johnson, L. L., Smiley, S. T. and Mohrs, M. (2009) Systemic but not local infections elicit immunosuppressive IL-10 production by natural killer cells. Cell Host and Microbe, 6(6), pp. 503-512. (doi: 10.1016/j.chom.2009.11.003) (PMID:20006839) (PMCID:PMC2796259)

Everts, B. et al. (2009) Omega-1, a glycoprotein secreted by Schistosoma mansoni eggs, drives Th2 responses. Journal of Experimental Medicine, 206(8), pp. 1673-1680. (doi: 10.1084/jem.20082460) (PMID:19635864) (PMCID:PMC2722183)

Couper, K. N., Lanthier, P. A., Perona-Wright, G. , Kummer, L. W., Chen, W., Smiley, S. T., Mohrs, M. and Johnson, L. L. (2009) Anti-CD25 antibody-mediated depletion of effector T cell populations enhances susceptibility of mice to acute but not chronic Toxoplasma gondii infection. Journal of Immunology, 182(7), pp. 3985-3994. (doi: 10.4049/jimmunol.0803053) (PMID:19299696) (PMCID:PMC3942880)

Perona-Wright, G. , Jenkins, S. J., O'Connor, R. A., Zienkiewicz, D., McSorley, H. J., Maizels, R. M. , Anderton, S. M. and MacDonald, A. S. (2009) A pivotal role for CD40-mediated IL-6 production by dendritic cells during IL-17 induction in vivo. Journal of Immunology, 182(5), pp. 2808-2815. (doi: 10.4049/jimmunol.0803553) (PMID:19234175)

2008

Perona-Wright, G. , Mohrs, K., Taylor, J., Zaph, C., Artis, D., Pearce, E. J. and Mohrs, M. (2008) Cutting edge: helminth infection induces IgE in the absence of μ- or δ-chain expression. Journal of Immunology, 181(10), pp. 6697-6701. (doi: 10.4049/jimmunol.181.10.6697) (PMID:18981085) (PMCID:PMC3066072)

Jenkins, S. J., Perona-Wright, G. and MacDonald, A. S. (2008) Full development of Th2 immunity requires both innate and adaptive sources of CD154. Journal of Immunology, 180(12), pp. 8083-8092. (doi: 10.4049/jimmunol.180.12.8083) (PMID:18523272)

2007

Jenkins, S. J., Perona-Wright, G. , Worsley, A. G.F., Ishii, N. and MacDonald, A. S. (2007) Dendritic cell expression of OX40 ligand acts as a costimulatory, not polarizing, signal for optimal Th2 priming and memory induction in vivo. Journal of Immunology, 179(6), pp. 3515-3523. (doi: 10.4049/jimmunol.179.6.3515) (PMID:17785785)

Perona-Wright, G. , Anderton, S. M., Howie, S. E.M. and Gray, D. (2007) IL-10 permits transient activation of dendritic cells to tolerize T cells and protect from central nervous system autoimmune disease. International Immunology, 19(9), pp. 1123-1134. (doi: 10.1093/intimm/dxm084) (PMID:17660499)

Mahajan, S., Cervera, A., Macleod, M. , Fillatreau, S., Perona-Wright, G. , Meek, S., Smith, A., MacDonald, A. and Gray, D. (2007) The role of ICOS in the development of CD4 T cell help and the reactivation of memory T cells. European Journal of Immunology, 37(7), pp. 1796-1808. (doi: 10.1002/eji.200636661) (PMID:17549732) (PMCID:PMC2699381)

2006

Perona-Wright, G. , Jenkins, S. J., Crawford, A., Gray, D., Pearce, E. J. and MacDonald, A. S. (2006) Distinct sources and targets of IL-10 during dendritic cell-driven Th1 and Th2 responses in vivo. European Journal of Immunology, 36(9), pp. 2367-2375. (doi: 10.1002/eji.200535722) (PMID:16917957)

Perona-Wright, G. , Jenkins, S. J. and MacDonald, A. S. (2006) Dendritic cell activation and function in response to Schistosoma mansoni. International Journal for Parasitology, 36(6), pp. 711-721. (doi: 10.1016/j.ijpara.2006.02.003) (PMID:16696981)

2002

Barnett, M. W., Fisher, C. E., Perona-Wright, G. and Davies, J. A. (2002) Signalling by glial cell line-derived neurotrophic factor (GDNF) requires heparan sulphate glycosaminoglycan. Journal of Cell Science, 115(23), pp. 4495-4503. (doi: 10.1242/jcs.00114) (PMID:12414995)

1998

Fu, G., Perona-Wright, G. and Barker, D. C. (1998) Leishmania braziliensis: characterisation of a complex specific subtelomeric repeat sequence and its use in the detection of parasites. Experimental Parasitology, 90(3), pp. 236-243. (doi: 10.1006/expr.1998.4326) (PMID:9806868)

This list was generated on Wed Apr 24 09:45:59 2024 BST.

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