Professor Paul Garside
- Senior Advisory Fellow (MVLS College Senior Management)
- Affiliate Researcher (School of Infection & Immunity)
telephone:
01413307251
email:
Paul.Garside@glasgow.ac.uk
RB526 Level B5, Iii - Gbrc, University Place, Glasgow G12 8TA
Publications
2024
Camargo da Rosa, L. , Scales, H. E. , Benson, R. A. , Brewer, J. M. , McInnes, I. B. and Garside, P. (2024) The effect of abatacept on T cell activation is not long-lived in vivo. Discovery Immunology, 3(1), kyad029. (doi: 10.1093/discim/kyad029)
2022
Bejad, M., Bonilha, C. S., McInnes, I. B. , Garside, P. and Benson, R. A. (2022) Tofacitinib inhibits CD4 T cell polarisation to Th1 during priming thereby leading to clinical impact in a model of experimental arthritis. Clinical and Experimental Rheumatology, 40(7), pp. 1313-1323. (doi: 10.55563/clinexprheumatol/4rqeg0) (PMID:34494958)
Prendergast, C. T., Benson, R. A. , Scales, H. E. , Bonilha, C. S., Cole, J. J., McInnes, I. , Brewer, J. M. and Garside, P. (2022) Dissecting the molecular control of immune cell accumulation in the inflamed joint. JCI Insight, 7(7), e151281. (doi: 10.1172/jci.insight.151281) (PMID:35192549) (PMCID:PMC9057592)
Camargo da Rosa, L. , Scales, H. E. , Makhija, S., Sutherland, K., Benson, R. A. , Brewer, J. M. and Garside, P. (2022) Revealing stromal and lymphoid sources of Col3a1-expression during inflammation using a novel reporter mouse. Discovery Immunology, 1(1), kyac008. (doi: 10.1093/discim/kyac008)
Meehan, G. R. , Scales, H. E. , McInnes, I. B. , Brewer, J. M. and Garside, P. (2022) Orally administered antigen can reduce or exacerbate pathology in an animal model of inflammatory arthritis dependent upon the timing of administration. Immunotherapy Advances, 2(1), ltac020. (doi: 10.1093/immadv/ltac020) (PMID:36268500) (PMCID:PMC9579813)
2021
Girard, A. et al. (2021) Raman spectroscopic analysis of skin as a diagnostic tool for Human African Trypanosomiasis. PLoS Pathogens, 17(11), e1010060. (doi: 10.1371/journal.ppat.1010060) (PMID:34780575) (PMCID:PMC8629383)
Meehan, G. R. et al. (2021) Preclinical models of arthritis for studying immunotherapy and immune tolerance. Annals of the Rheumatic Diseases, 80(10), pp. 1268-1277. (doi: 10.1136/annrheumdis-2021-220043) (PMID:34380700)
Raponi, A., Brewer, J. M. , Garside, P. and Laera, D. (2021) Nanoalum adjuvanted vaccines: small details make a big difference. Seminars in Immunology, 56, 101544. (doi: 10.1016/j.smim.2021.101544) (PMID:34895823)
Bonilha, C. S., Benson, R. A. , Scales, H. E. , Brewer, J. M. and Garside, P. (2021) Junctional adhesion molecule-A on dendritic cells regulates Th1 differentiation. Immunology Letters, 235, pp. 32-40. (doi: 10.1016/j.imlet.2021.05.001) (PMID:34000305)
Al Khabouri, S., Benson, R. A. , Prendergast, C. T., Gray, J. I., Otto, T. D. , Brewer, J. M. and Garside, P. (2021) TCRß sequencing reveals spatial and temporal evolution of clonal CD4 T cell responses in a breach of tolerance model of inflammatory arthritis. Frontiers in Immunology, 12, 669856. (doi: 10.3389/fimmu.2021.669856) (PMID:33986757) (PMCID:PMC8110912)
Gray, J. I. et al. (2021) Tolerance induction in memory CD4 T cells is partial and reversible. Immunology, 162(1), pp. 68-83. (doi: 10.1111/imm.13263) (PMID:32931017) (PMCID:PMC7730012)
2020
Bonilha, C. S., Benson, R. A. , Brewer, J. M. and Garside, P. (2020) Targeting opposing immunological roles of the junctional adhesion molecule-A in autoimmunity and cancer. Frontiers in Immunology, 11, 602094. (doi: 10.3389/fimmu.2020.602094) (PMID:33324419) (PMCID:PMC7723963)
Osii, R. S., Otto, T. D. , Garside, P. , Ndungu, F. and Brewer, J. M. (2020) The impact of malaria parasites on dendritic cell–T cell interaction. Frontiers in Immunology, 11, 1597. (doi: 10.3389/fimmu.2020.01597)
Alfituri, O. A., Quintana, J. F. , MacLeod, A. , Garside, P. , Benson, R. A. , Brewer, J. M., Mabbott, N. A., Morrison, L. J. and Capewell, P. (2020) To the skin and beyond: the immune response to African trypanosomes as they enter and exit the vertebrate host. Frontiers in Immunology, 11, 1250. (doi: 10.3389/fimmu.2020.01250) (PMID:32595652) (PMCID:PMC7304505)
Meehan, G. R. , Scales, H. E. , Osii, R., De Niz, M., Lawton, J. C., Marti, M. , Garside, P. , Craig, A. and Brewer, J. M. (2020) Developing a xenograft model of human vasculature in the mouse ear pinna. Scientific Reports, 10, 2058. (doi: 10.1038/s41598-020-58650-y) (PMID:32029768) (PMCID:PMC7004987)
MacRitchie, N. et al. (2020) The aorta can act as site of naïve CD4+ T cell priming. Cardiovascular Research, 116(2), pp. 306-316. (doi: 10.1093/cvr/cvz102) (PMID:30980670)
2019
Noonan, J., Grassia, G., MacRitchie, N., Garside, P. , Guzik, T. J., Bradshaw, A. C. and Maffia, P. (2019) A novel triple-cell two-dimensional model to study immune-vascular interplay in atherosclerosis. Frontiers in Immunology, 10, 849. (doi: 10.3389/fimmu.2019.00849) (PMID:31068936) (PMCID:PMC6491724)
Hayes, A. J. et al. (2019) Spatiotemporal modeling of the key migratory events during the initiation of adaptive immunity. Frontiers in Immunology, 10, 598. (doi: 10.3389/fimmu.2019.00598) (PMID:31024523) (PMCID:PMC6460458)
Alfituri, O. A., Ajibola, O., Brewer, J. M. , Garside, P. , Benson, R. A. , Peel, T., Morrison, L. J. and Mabbott, N. A. (2019) Effects of host-derived chemokines on the motility and viability of Trypanosoma brucei. Parasite Immunology, 41(2), e12609. (doi: 10.1111/pim.12609) (PMID:30525202) (PMCID:PMC6767366)
Capewell, P. et al. (2019) Resolving the apparent transmission paradox of African sleeping sickness. PLoS Biology, 17(1), e3000105. (doi: 10.1371/journal.pbio.3000105) (PMID:30633739) (PMCID:PMC6345479)
2018
Scales, H. E. et al. (2018) A novel cellular pathway of antigen presentation and CD4 T cell activation in vivo. Frontiers in Immunology, 9, 2684. (doi: 10.3389/fimmu.2018.02684)
Benson, R. A. et al. (2018) Non-invasive multiphoton imaging of islets transplanted into the pinna of the NOD mouse ear reveals the immediate effect of anti-CD3 treatment in autoimmune diabetes. Frontiers in Immunology, 9, 1006. (doi: 10.3389/fimmu.2018.01006) (PMID:29867981) (PMCID:PMC5968092)
Prendergast, C. T., Patakas, A., Al-Khabouri, S., McIntyre, C. L., McInnes, I. B. , Brewer, J. M. , Garside, P. and Benson, R. A. (2018) Visualising the interaction of CD4 T cells and DCs in the evolution of inflammatory arthritis. Annals of the Rheumatic Diseases, 77(4), pp. 579-588. (doi: 10.1136/annrheumdis-2017-212279) (PMID:29358281)
Benson, R. A. , McInnes, I. B. , Garside, P. and Brewer, J. M. (2018) Model answers: rational application of murine models in Arthritis research. European Journal of Immunology, 48(1), pp. 32-38. (doi: 10.1002/eji.201746938) (PMID:29193037) (PMCID:PMC5814907)
MacRitchie, N., Grassia, G., Noonan, J., Garside, P. , Graham, D. and Maffia, P. (2018) Molecular imaging of atherosclerosis: spotlight on Raman spectroscopy and surface-enhanced Raman scattering. Heart, 104(6), pp. 460-467. (doi: 10.1136/heartjnl-2017-311447) (PMID:29061690) (PMCID:PMC5861389)
Noonan, J. et al. (2018) In vivo multiplex molecular imaging of vascular inflammation using surface-enhanced Raman spectroscopy. Theranostics, 8(22), pp. 6195-6209. (doi: 10.7150/thno.28665) (PMID:30613292) (PMCID:PMC6299693)
2017
Jaigrdar, S. A., Benson, R. A. , Elmesmari, A., Kurowska-Stolarska, M. S. , McInnes, I. B. , Garside, P. and Macleod, M. K.L. (2017) Sphingosine-1-phosphate promotes the persistence of activated CD4 T cells in inflamed sites. Frontiers in Immunology, 8, 1627. (doi: 10.3389/fimmu.2017.01627) (PMID:29225602) (PMCID:PMC5705559)
Benson, R. A. , Brewer, J. M. and Garside, P. (2017) Visualizing and tracking T cell motility In vivo. In: Rainger, G. E. and Mcgettrick, H. M. (eds.) T-Cell Trafficking: Methods and Protocols [Second Edition]. Series: Methods in molecular biology (1591). Springer: New York, pp. 27-41. ISBN 9781493969296 (doi: 10.1007/978-1-4939-6931-9_3)
Stephen, J., Scales, H.E. , Benson, R.A. , Erben, D., Garside, P. and Brewer, J.M. (2017) Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity. npj Vaccines, 2, 1. (doi: 10.1038/s41541-016-0001-5) (PMID:29263862) (PMCID:PMC5604741)
2016
Capewell, P. et al. (2016) The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes. eLife, 5, e17716. (doi: 10.7554/eLife.17716) (PMID:27653219) (PMCID:PMC5065312)
Cosway, E., Anderson, G., Garside, P. and Prendergast, C. (2016) The thymus and rheumatology: should we care? Current Opinion in Rheumatology, 28(2), pp. 189-195. (doi: 10.1097/bor.0000000000000251) (PMID:26751840) (PMCID:PMC4732010)
Patakas, A., Ji, R., Weir, W. , Connolly, S. E., Benson, R. A. , Nadler, S. G., Brewer, J. M. , McInnes, I. B. and Garside, P. (2016) Abatacept inhibits T cell priming by inducing of a unique transcriptional profile that reduces their ability to activate antigen presenting cells. Arthritis and Rheumatology, 68(3), pp. 627-638. (doi: 10.1002/art.39470) (PMID:26473409)
Scales, H. E. , Ierna, M., Smith, K. M., Ross, K., Meiklejohn, G. R., Patterson-Kane, J. C., McInnes, I. B., Brewer, J. M. , Garside, P. and Maffia, P. (2016) Assessment of murine collagen-induced arthritis by longitudinal non-invasive duplexed molecular optical imaging. Rheumatology, 55(3), pp. 564-572. (doi: 10.1093/rheumatology/kev361) (PMID:26475798)
2015
Benson, R. A. , Macleod, M. K.L. , Hale, B. G.H. , Patakas, A., Garside, P. and Brewer, J. M. (2015) Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo. eLife, 4, e06994. (doi: 10.7554/eLife.06994) (PMID:26258879) (PMCID:PMC4558563)
Hawkins, P., Armstrong, R., Boden, T., Garside, P. , Knight, K., Lilley, E., Seed, M., Wilkinson, M. and Williams, R. O. (2015) Applying refinement to the use of mice and rats in rheumatoid arthritis research. Inflammopharmacology, 23(4), pp. 131-150. (doi: 10.1007/s10787-015-0241-4) (PMID:26168847) (PMCID:PMC4508365)
Hu, D. et al. (2015) Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors. Immunity, 42(6), pp. 1100-1115. (doi: 10.1016/j.immuni.2015.05.015) (PMID:26084025) (PMCID:PMC4678289)
Benson, R. A. , McInnes, I. B. , Brewer, J. M. and Garside, P. (2015) Cellular imaging in rheumatic diseases. Nature Reviews Rheumatology, 11(6), pp. 357-367. (doi: 10.1038/nrrheum.2015.34) (PMID:25800215)
Oliver-Bell, J., Butcher, J.P., Malcolm, J. , Macleod, M.K.L. , Adrados Planell, A., Campbell, L., Nibbs, R.J.B. , Garside, P. , McInnes, I.B. and Culshaw, S. (2015) Periodontitis in the absence of B cells and specific anti-bacterial antibody. Oral Microbiology and Immunology, 30(2), pp. 160-169. (doi: 10.1111/omi.12082) (PMID:25219939)
Platt, A. M., Benson, R. A. , McQueenie, R., Butcher, J. P., Braddock, M., Brewer, J. M. , McInnes, I. B. and Garside, P. (2015) The active metabolite of spleen tyrosine kinase inhibitor fostamatinib abrogates the CD4+ T cell-priming capacity of dendritic cells. Rheumatology, 54(1), pp. 169-177. (doi: 10.1093/rheumatology/keu273) (PMID:25065010)
2014
Lawton, J. C., Benson, R. A. , Garside, P. and Brewer, J. M. (2014) Using lymph node transplantation as an approach to image cellular interactions between the skin and draining lymph nodes during parasitic infections. Parasitology International, 63(1), pp. 165-170. (doi: 10.1016/j.parint.2013.07.010)
David, A., Crawford, F., Garside, P. , Kappler, J. W., Marrack, P. and Macleod, M. (2014) Tolerance induction in memory CD4 T cells requires two rounds of antigen-specific activation. Proceedings of the National Academy of Sciences of the United States of America, 111(21), pp. 7735-7740. (doi: 10.1073/pnas.1406218111) (PMID:24821788) (PMCID:PMC4040609)
Maddaluno, M., MacRitchie, N., Grassia, G., Ialenti, A., Butcher, J. P., Garside, P. , Brewer, J. M. and Maffia, P. (2014) Murine aortic smooth muscle cells acquire, though fail to present exogenous protein antigens on major histocompatibility complex class II molecules. BioMed Research International(949845), (doi: 10.1155/2014/949845) (PMID:25136640) (PMCID:PMC4127268)
2013
Grassia, G., MacRitchie, N., Platt, A., Brewer, J. , Garside, P. and Maffia, P. (2013) Plasmacytoid dendritic cells: biomarkers or potential therapeutic targets in atherosclerosis? Pharmacology and Therapeutics, 137(2), pp. 172-182. (doi: 10.1016/j.pharmthera.2012.10.001) (PMID:23059425)
2012
MacRitchie, N. et al. (2012) Plasmacytoid dendritic cells play a key role in promoting atherosclerosis in apolipoprotein e-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(11), pp. 2569-2579. (doi: 10.1161/ATVBAHA.112.251314)
Patakas, A., Benson, R.A. , Withers, D.R., Conigliaro, P., McInnes, I.B. , Brewer, J.M. and Garside, P. (2012) Th17 effector cells support B bell responses outside of germinal centres. PLoS ONE, 7(11), e49715. (doi: 10.1371/journal.pone.0049715) (PMID:23166752) (PMCID:PMC3500323)
Gibson, V.B. et al. (2012) A novel method to allow noninvasive, longitudinal imaging of the murine immune system in vivo. Blood, 119(11), pp. 2545-2551. (doi: 10.1182/blood-2011-09-378356) (PMID:22271449) (PMCID:PMC3398133)
Ghimire, T.R., Benson, R.A. , Garside, P. and Brewer, J.M. (2012) Alum increases antigen uptake, reduces antigen degradation and sustains antigen presentation by DCs in vitro. Immunology Letters, 147(1-2), pp. 55-62. (doi: 10.1016/j.imlet.2012.06.002)
Hutchison, S., Benson, R.A. , Gibson, V.B., Pollock, A.H., Garside, P. and Brewer, J.M. (2012) Antigen depot is not required for alum adjuvanticity. FASEB Journal, 26(3), pp. 1272-1279. (doi: 10.1096/fj.11-184556) (PMID:22106367) (PMCID:PMC3289510)
McQueenie, R., Stevenson, R., Benson, R. , MacRitchie, N., McInnes, I. , Maffia, P. , Faulds, K., Graham, D., Brewer, J. and Garside, P. (2012) Detection of inflammation in vivo by surface-enhanced raman scattering provides higher sensitivity than conventional fluorescence imaging. Analytical Chemistry, 84(14), pp. 5968-5975. (doi: 10.1021/ac3006445)
Patakas, A., Benson, R.A. , Withers, D.R., Conigliaro, P., McInnes, I.B. , Brewer, J.M. and Garside, P. (2012) Th17 effector cells support B cell responses outside of germinal centres. PLoS ONE, 7(11), e49715. (doi: 10.1371/journal.pone.0049715) (PMID:23161902) (PMCID:PMC3812864)
Vincent, T.L., Williams, R.O., Maciewicz, R., Silman, A. and Garside, P. (2012) Mapping pathogenesis of arthritis through small animal models. Rheumatology, 51(11), pp. 1931-1941. (doi: 10.1093/rheumatology/kes035)
Wenink, M.H., Santegoets, K.C.M., Platt, A.M., van den Berg, W.B., van Riel, P.L.C.M., Garside, P. , Radstake, T.R.D.J. and McInnes, I.B. (2012) Abatacept modulates proinflammatory macrophage responses upon cytokine-activated T cell and Toll-like receptor ligand stimulation. Annals of the Rheumatic Diseases, 71(1), pp. 80-83. (doi: 10.1136/annrheumdis-2011-200348) (PMID:21908454)
2011
Benson, R.A. , Patakas, A., McQueenie, R., Ross, K., McInnes, I.B. , Brewer, J.M. and Garside, P. (2011) Arthritis in space and time – to boldly go! FEBS Letters, 585(23), pp. 2640-3648. (doi: 10.1016/j.febslet.2011.04.069) (PMID:21570969)
Lee, K. M. et al. (2011) D6 facilitates cellular migration and fluid flow to lymph nodes by suppressing lymphatic congestion. Blood, 118(23), pp. 6220-6229. (doi: 10.1182/blood-2011-03-344044)
Butcher, J.P., Malcolm, J. , Benson, R.A. , Deng, D.M., Brewer, J.M. , Garside, P. and Culshaw, S. (2011) Effects of streptococcus mutans on dendritic cell activation and function. Journal of Dental Research, 90(10), pp. 1221-1227. (doi: 10.1177/0022034511412970)
Conigliaro, P., Benson, R. A. , Patakas, A., Kelly, S. M., Valesini, G., Holmdahl, R., Brewer, J. M. , McInnes, I. B. and Garside, P. (2011) Characterization of the anticollagen antibody response in a new model of chronic polyarthritis. Arthritis and Rheumatism, 63(8), pp. 2299-2308. (doi: 10.1002/art.30413) (PMID:21506101)
Patakas, A., Platt, A. M., Butcher, J. P., Maffia, P. , McInnes, I. B. , Brewer, J. M. , Garside, P. and Benson, R. A. (2011) Putative existence of reciprocal dialogue between Tfh and B cells and its impact on infectious and autoimmune disease. Immunology Letters, 138(1), pp. 38-46. (doi: 10.1016/j.imlet.2011.03.002) (PMID:21419798)
Fumagalli, S. et al. (2011) In vivo real-time multiphoton imaging of t lymphocytes in the mouse brain after experimental stroke. Stroke, 42(5), pp. 1429-1436. (doi: 10.1161/STROKEAHA.110.603704)
Kollias, G. et al. (2011) Animal models for arthritis: innovative tools for prevention and treatment. Annals of the Rheumatic Diseases, 70(8), pp. 1357-1362. (doi: 10.1136/ard.2010.148551)
2010
Platt, A. M., Gibson, V. B., Patakas, A., Benson, R. A. , Nadler, S. G., Brewer, J. M. , McInnes, I. and Garside, P. (2010) Abatacept limits breach of self-tolerance in a Murine model of arthritis via effects on the generation of T follicular helper cells. Journal of Immunology, 185(3), pp. 1558-1567. (doi: 10.4049/jimmunol.1001311) (PMID:20601593)
Benson, R.A. , Patakas, A., Conigliaro, P., Rush, C. M., Garside, P. , McInnes, I. B. and Brewer, J. M. (2010) Identifying the Cells Breaching Self-Tolerance in Autoimmunity. Journal of Immunology, 184(11), pp. 6378-6385. (doi: 10.4049/jimmunol.0903951) (PMID:20421640)
Rush, C.M., Mitchell, T.J. and Garside, P. (2010) A detailed characterisation of the distribution and presentation of DNA vaccine encoded antigen. Vaccine, 28(6), pp. 1620-1634. (doi: 10.1016/j.vaccine.2009.11.014)
Ortolano, F., Maffia, P. , Dever, G., Rodolico, G. , Millington, O.R., De Simoni, M.G., Brewer, J.M. , Bushell, T.J., Garside, P. and Carswell, H.V. (2010) Advances in imaging of new targets for pharmacological intervention in stroke: real-time tracking of T-cells in the ischaemic brain. British Journal of Pharmacology, 159(4), pp. 808-811. (doi: 10.1111/j.1476-5381.2009.00527.x) (PMID:20015295) (PMCID:PMC2829206)
Conigliaro, P., Perricone, C., Benson, R.A. , Garside, P. , Brewer, J.M. , Perricone, R. and Valesini, G. (2010) The type I IFN system in rheumatoid arthritis. Autoimmunity, 43(3), pp. 220-225. (doi: 10.3109/08916930903510914)
De Simoni, M.G., Fumagalli, S., Ortolano, F., Maffia, P. , Carswell, H.C. and Garside, P. (2010) In vivo blood flow dynamics after focal ischemia in mice. In: International Stroke Conference 2010, San Antonio, TX, 23-26 Feb 2010, e225. (doi: 10.1161/01.str.0000366114.11305.66)
Garside, P. and Brewer, J. (2010) In vivo imaging of infection immunology—4I’s! Seminars in Immunopathology, 32(3), pp. 289-296. (doi: 10.1007/s00281-010-0215-y)
Grassia, G., Dever, G., Gordon, P., McInnes, I. , Spanbroek, R., Habenicht, A.J.R., Brewer, J. , Garside, P. and Maffia, P. (2010) Real time imaging of lymphocytes in APOE-/- mouse aortic tertiary lymphoid organs. In: Spring Meeting of the British-Society-for-Cardiovascular-Research 2010, Manchester, UK, 07-08 June 2010, e12. (doi: 10.1136/hrt.2010.205781.11)
Millington, O. R., Brewer, J. M. , Garside, P. and Maffia, P. (2010) Imaging interactions between the immune and cardiovascular systems in vivo by multiphoton microscopy. In: Marelli-Berg, F. M. and Nourshargh, S. (eds.) T-Cell Trafficking: Methods and Protocols. Series: Methods in Molecular Biology, 616 (616). Humana Press Inc, pp. 193-206. ISBN 9781607614609 (doi: 10.1007/978-1-60761-461-6_13)
2009
Ortolano, F. et al. (2009) Imaging T-cell movement in the brain during experimental cerebral malaria. Parasite Immunology, 31(3), 147-150 (4). (doi: 10.1111/j.1365-3024.2008.01090.x)
Jongbloed, S.L., Benson, R. , Nickdel, M.B., Garside, P. , McInnes, I. and Brewer, J.M. (2009) Plasmacytoid dendritic cells regulate breach of self-tolerance in autoimmune arthritis. Journal of Immunology, 182(2), pp. 963-968. (doi: 10.4049/jimmunol.182.2.963) (PMID:19124739)
Dever, G., Rodolico, G., Berrino, L., McInnes, I. , Brewer, J. , Garside, P. and Maffia, P. (2009) Three dimensional imaging of atherosclerotic plaques in apolipoprotien e-deficient mice. In: Spring Meeting of the British-Society-for-Cardiovascular-Research 2009, Oxford, Uk, 02-04 Apr 2009, (doi: 10.1136/hrt.2009.178137i)
Dever, G., Rodolico, G., Liberato, B., McInnes, I. , Brewer, J. , Garside, P. and Maffia, P. (2009) Confocal and multiphoton laser scanning microscopy provide 3-dimensional imaging of atherosclerotic plaques in apolipoprotein E-deficient mice. In: Arteriosclerosis, Thrombosis and Vascular Biology Annual Conference 2009, Washington DC, USA, 29 Apr - 1 May 2009, e74. (doi: 10.1161/ATV.0B013E3181AB66E7)
Hueber, A., Stevenson, R., Stokes, R., Graham, D., Garside, P. and McInnes, I. (2009) Imaging inflammation in real time-future of nanoparticles. Autoimmunity, 42(4), pp. 368-372. (doi: 10.1080/08916930902832298) (PMID:19811304)
Hutchison, S., Choo-Kang, B.S.W., Gibson, V.B., Bundick, R.V., Leishman, A.J., Brewer, J.M., McInnes, I. and Garside, P. (2009) An investigation of the impact of the location and timing of antigen-specific T cell division on airways inflammation. Clinical and Experimental Immunology, 155(1), pp. 107-116. (doi: 10.1111/j.1365-2249.2008.03800.x) (PMID:19076834)
Nickdel, M.B., Conigliaro, P., Valesini, G., Hutchison, S., Benson, R. , Bundick, R.V., Leishman, A.J., McInnes, I. , Brewer, J.M. and Garside, P. (2009) Dissecting the contribution of innate and antigen-specific pathways to the breach of self-tolerance observed in a murine model of arthritis. Annals of the Rheumatic Diseases, 68(6), pp. 1059-1066. (doi: 10.1136/ard.2008.089300) (PMID:18635595)
Rush, C.M., Millington, O.R., Hutchison, S., Bryson, K., Brewer, J.M. and Garside, P. (2009) Characterization of CD4+ T-cell-dendritic cell interactions during secondary antigen exposure in tolerance and priming. Immunology, 128(4), pp. 463-471. (doi: 10.1111/j.1365-2567.2009.03124.x)
2008
Thompson, J., Millington, O.R., Garside, P. and Brewer, J.M. (2008) What can transgenic parasites tell us about the development of Plasmodium-specific immune responses? Parasite Immunology, 30(4), pp. 223-233. (doi: 10.1111/j.1365-3024.2007.01011.x) (PMID:18324925)
Marshall, F. A., Watson, K. A., Garside, P. , Harnett, M. M. and Harnett, W. (2008) Effect of activated antigen-specific B cells on ES-62-mediated modulation of effector function of heterologous antigen-specific T cells in vivo. Immunology, 123(3), pp. 411-425. (doi: 10.1111/j.1365-2567.2007.02706.x)
Garside, P. and Brewer, J. M. (2008) Real-time imaging of the cellular interactions underlying tolerance, priming, and responses to infection. Immunological Reviews, 221(1), pp. 130-146. (doi: 10.1111/j.1600-065X.2008.00587.x) (PMID:18275479)
Hutchison, S., Choo-Kang, B.S.W., Bundick, R.V., Leishman, A.J., Brewer, J.M., McInnes, I. and Garside, P. (2008) Tumour necrosis factor-alpha blockade suppresses murine allergic airways inflammation. Clinical and Experimental Immunology, 151(1), pp. 114-122. (doi: 10.1111/j.1365-2249.2007.03509.x) (PMID:17931392)
2007
Millington, O.R., Zinselmeyer, B.H., Brewer, J.M. , Garside, P. and Rush, C.M. (2007) Lymphocyte tracking and interactions in secondary lymphoid organs. Inflammation Research, 56(10), pp. 391-401. (doi: 10.1007/s00011-007-7017-2) (PMID:18026695)
Maffia, P. , Zinselmeyer, B.H., Ialenti, A., Kennedy, S. , Baker, A.H., McInnes, I., Brewer, J.M. and Garside, P. (2007) Multiphoton microscopy for 3-dimensional imaging of lymphocyte recruitment into apolipoprotein-E-deficient mouse carotid artery. Circulation, 115(11), E326-E328. (doi: 10.1161/CIRCULATIONAHA.106.658492) (PMID:17372180)
Millington, O.R., Gibson, V.B., Rush, C.M., Zinselmeyer, B.H., Phillips, R.S., Garside, P. and Brewer, J.M. (2007) Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells. PLoS Pathogens, 3(10), e143. (doi: 10.1371/journal.ppat.0030143)
2006
Maffia, P. , Grassia, G., Di Meglio, P., Carnuccio, R., Berrino, L., Garside, P. , Ianaro, A. and Ialenti, A. (2006) Neutralization of interleukin-18 inhibits neointimal formation in a rat model of vascular injury. Circulation, 114, pp. 430-437. (doi: 10.1161/CIRCULATIONAHA.105.602714) (PMID:16864728)
Ierna, M. X., Scales, H. E. , Schwarz, H., Bunce, C., McIlgorm, A., Garside, P. and Lawrence, C. E. (2006) OX40 interactions in gastrointestinal nematode infection. Immunology, 117(1), pp. 108-116. (doi: 10.1111/j.1365-2567.2005.02271.x) (PMID:16423046)
Duffy, D., Yang, C., Heath, A., Garside, P. and Bell, E. (2006) Naive T-cell receptor transgenic T cells help memory B cells produce antibody. Immunology, 119, pp. 376-384. (doi: 10.1111/j.1365-2567.2006.02446.x)
Rush, C., Mitchell, T., Burke, B. and Garside, P. (2006) Dissecting the components of the humoral immune response elicited by DNA vaccines. Vaccine, 24, pp. 776-784. (doi: 10.1016/j.vaccine.2005.08.080)
Schneider, H., Downey, J., Smith, A., Zinselmeyer, B., Rush, C., Brewer, J., Wei, B., Hogg, N., Garside, P. and Rudd, C. (2006) Reversal of the TCR stop signal by CTLA-4. Science, 313, pp. 1972-1975. (doi: 10.1126/science.1131078)
Smith, K., Garside, P., Mcneil, R. and Brewer, J. (2006) Analysis of costimulatory molecule expression on antigen-specific T and B cells during the induction of adjuvant-induced Th1 and Th2 type responses. Vaccine, 24, pp. 3035-3043. (doi: 10.1016/j.vaccine.2005.10.027)
Yang, C., Sparshott, S., Duffy, D., Garside, P. and Bell, E. (2006) The phenotype and survival of antigen-stimulated transgenic CD4 T cells in vivo: the influence of persisting antigen. International Immunology, 18, pp. 515-523. (doi: 10.1093/intimm/dxh392)
2005
Boitelle, A., Di Lorenzo, C., Scales, H.E. , Devaney, E. , Kennedy, M.W., Garside, P. and Lawrence, C.E. (2005) Contrasting effects of acute and chronic gastro-intestinal helminth infections on a heterologous immune response in a transgenic adoptive transfer model. International Journal for Parasitology, 35(7), pp. 765-775. (doi: 10.1016/j.ijpara.2005.02.013) (PMID:15893319)
Millington, O. R., Di Lorenzo, C., Phillips, R. S., Garside, P. and Brewer, J. M. (2005) Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function. Journal of Biology, 5, 5. (doi: 10.1186/jbiol34) (PMID:16611373) (PMCID:PMC1561486)
Choo-Kang, B., Hutchison, S., Nickdel, M., Bundick, R., Leishman, A., Brewer, J., McInnes, I. and Garside, P. (2005) TNF-blocking therapies: an alternative mode of action? Trends in Immunology, 26, pp. 518-522. (doi: 10.1016/j.it.2005.07.007) (PMID:16087401)
Grierson, A., Mitchell, P., Adams, C., Mowat, A., Brewer, J., Harnett, M. and Garside, P. (2005) Direct quantitation of T cell signaling by laser scanning cytometry. Journal of Immunological Methods, 301, pp. 140-153. (doi: 10.1016/j.jim.2005.04.011)
Kerr, A., Kirkham, L., Kadioglu, A., Andrew, P., Garside, P., Thompson, H. and Mitchell, T. (2005) Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts. Microbes and Infection, 7, pp. 845-852. (doi: 10.1016/j.mincinf.2005.02.011)
Marshall, F., Grierson, A., Garside, P., Harnett, W. and Harnett, M. (2005) ES-62, an immunomodulator secreted by filarial nematodes, suppresses clonal expansion and modifies effector function of heterologous antigen-specific T cells in vivo. Journal of Immunology, 175, pp. 5817-5826.
Mirenda, V., Millington, O., Lechler, R., Scott, D., Hernandez-Fuentes, M., Read, J., Tan, P., George, A., Garside, P. and Marelli-Berg, F. (2005) Tolerant T cells display impaired trafficking ability. European Journal of Immunology, 35, pp. 2146-2156. (doi: 10.1002/eji.200425823)
Zinselmeyer, B. H. et al. (2005) In situ characterization of CD4+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance. Journal of Experimental Medicine, 201(11), pp. 1815-1823. (doi: 10.1084/jem.20050203)
Zinselmeyer, B. et al. (2005) In situ characterization of CD4(+) T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance. Journal of Experimental Medicine, 201, pp. 1815-1823. (doi: 10.1084/jem.20050203)
2004
Scales, H. E. , Ierna, M. X., Gutierrez-Ramos, J.-C., Coyle, A. J., Garside, P. and Lawrence, C. E. (2004) Effect of inducible costimulator blockade on the pathological and protective immune responses induced by the gastrointestinal helminth Trichinella spiralis. European Journal of Immunology, 34, pp. 2854-2862. (doi: 10.1002/eji.200324364) (PMID:5368302)
Smith, K. M., Brewer, J. M. , Rush, C. M., Riley, J. and Garside, P. (2004) In vivo generated Th1 cells can migrate to B cell follicles to support B cell responses. Journal of Immunology, 173(3), pp. 1640-1646. (doi: 10.4049/jimmunol.173.3.1640) (PMID:15265892)
Maffia, P. , Brewer, J. M. , Gracie, J. A., Ianaro, A., Leung, B. P., Mitchell, P. J., Smith, K. M., McInnes, I. B. and Garside, P. (2004) Inducing experimental arthritis and breaking self-tolerance to joint-specific antigens with trackable, ovalbumin-specific T cells. Journal of Immunology, 173(1), pp. 151-156. (doi: 10.4049/jimmunol.173.1.151) (PMID:15210769)
Adams, C., Grierson, A., Mowat, A., Harnett, M. and Garside, P. (2004) Differences in the kinetics, amplitude, and localization of ERK activation in anergy and priming revealed at the level of individual primary T cells by laser scanning cytometry. Journal of Immunology, 173, pp. 1579-1586.
Adams, C., Kobets, N., Meiklejohn, G., Millington, O., Grierson, A., Rush, C., Smith, K. and Garside, P. (2004) Tracking lymphocytes in vivo. Archivum Immunologiae et Therapiae Experimentalis, 52, pp. 173-187.
Garside, P., Millington, O. and Smith, K. (2004) The anatomy of mucosal immune responses. Oral Tolerance, 1029, pp. 9-15. (doi: 10.1196/annals.1309.002)
Kobets, N., Kennedy, K., O'Donnell, D. and Garside, P. (2004) An investigation of the ability of orally primed and tolerised T cells to help B cells upon mucosal challenge. Immunology, 112, pp. 550-558. (doi: 10.1046/j.1365-2567.2004.01913.x)
Millington, O., Mowat, A. and Garside, P. (2004) Induction of bystander suppression by feeding antigen occurs despite normal clonal expansion of the bystander T cell population. Journal of Immunology, 173, pp. 6059-6064.
Millington, O., Wei, X., Garside, P. and Mowat, A. (2004) Interleukin-15 is not required for the induction or maintenance of orally induced peripheral tolerance. Immunology, 113, pp. 304-309. (doi: 10.1111/j.1365-2567.2004.01965.x)
Smith, K., Brewer, J., Mowat, A., Ron, Y. and Garside, P. (2004) The influence of follicular migration on T-cell differentiation. Immunology, 111, pp. 248-251. (doi: 10.1111/j.1365-2567.2004.01813.x)
2003
Boitelle, A., Scales, H. E. , Di Lorenzo, C., Devaney, E. , Kennedy, M. W. , Garside, P. and Lawrence, C. E. (2003) Investigating the impact of helminth products on immune responsiveness using a TCR transgenic adoptive transfer system. Journal of Immunology, 171(1), pp. 447-454. (doi: 10.4049/jimmunol.171.1.447) (PMID:12817029)
Smith, K. M., Brewer, J. M. , Webb, P., Coyle, A. J., Gutierrez-Ramos, C. and Garside, P. (2003) Inducible costimulatory molecule-B7-related protein 1 interactions are important for the clonal expansion and B cell helper functions of naive, Th1, and Th2 T cells. Journal of Immunology, 170(5), pp. 2310-2315. (doi: 10.4049/jimmunol.170.5.2310) (PMID:12594252)
Adams, C. L., Macleod, M. K.L. , Milner-White, E. J., Aitken, R., Garside, P. and Stott, D.I. (2003) Complete analysis of the B-cell response to a protein antigen, from in vivo germinal centre formation to 3-D modelling of affinity maturation. Immunology, 108(3), pp. 274-287. (doi: 10.1046/j.1365-2567.2003.01583.x) (PMID:12603593)
Eaton, A., Xu, D. and Garside, P. (2003) Administration of exogenous interleukin-18 and interleukin-12 prevents the induction of oral tolerance. Immunology, 108, pp. 196-203.
Kobets, N., Kennedy, K. and Garside, P. (2003) An investigation of the distribution of antigen fed in tolerogenic or immunogenic forms. Immunology Letters, 88, pp. 147-155. (doi: 10.1016/S0165-2478(03)00076-2)
2002
Rush, C., Mitchell, T. and Garside, P. (2002) Efficient priming of CD4(+) and CD8(+) T cells by DNA vaccination depends on appropriate targeting of sufficient levels of immunologically relevant antigen to appropriate processing pathways. Journal of Immunology, 169, pp. 4951-4960.
Smith, K., Davidson, J. and Garside, P. (2002) T-cell activation occurs simultaneously in local and peripheral lymphoid tissue following oral administration of a range of doses of immunogenic or tolerogenic antigen although tolerized T cells display a defect in cell division. Immunology, 106, pp. 144-158.
Smith, K., McAskill, F. and Garside, P. (2002) Orally tolerized T cells are only able to enter B cell follicles following challenge with antigen in adjuvant, but they remain unable to provide B cell help. Journal of Immunology, 168, pp. 4318-4325.
2001
Garside, P. and Mowat, A. (2001) Oral tolerance. Seminars in Immunology, 13, pp. 177-185. (doi: 10.1006/smim.2001.0310)
2000
Smith, K., Pottage, L., Thomas, E., Leishman, A., Doig, T., Xu, D., Liew, F. and Garside, P. (2000) Th1 and Th2CD4(+) T cells provide help for B cell clonal expansion and antibody synthesis in a similar manner in vivo. Journal of Immunology, 165(6), pp. 3136-3144.
1994
Taylor-Robinson, A. W., Liew, F. Y., Severn, A., Xu, D., McSorley, S. J., Garside, P. , Padron, J. and Phillips, R. S. (1994) Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells. European Journal of Immunology, 24(4), pp. 980-984. (doi: 10.1002/eji.1830240430) (PMID:8149966)
Articles
Camargo da Rosa, L. , Scales, H. E. , Benson, R. A. , Brewer, J. M. , McInnes, I. B. and Garside, P. (2024) The effect of abatacept on T cell activation is not long-lived in vivo. Discovery Immunology, 3(1), kyad029. (doi: 10.1093/discim/kyad029)
Bejad, M., Bonilha, C. S., McInnes, I. B. , Garside, P. and Benson, R. A. (2022) Tofacitinib inhibits CD4 T cell polarisation to Th1 during priming thereby leading to clinical impact in a model of experimental arthritis. Clinical and Experimental Rheumatology, 40(7), pp. 1313-1323. (doi: 10.55563/clinexprheumatol/4rqeg0) (PMID:34494958)
Prendergast, C. T., Benson, R. A. , Scales, H. E. , Bonilha, C. S., Cole, J. J., McInnes, I. , Brewer, J. M. and Garside, P. (2022) Dissecting the molecular control of immune cell accumulation in the inflamed joint. JCI Insight, 7(7), e151281. (doi: 10.1172/jci.insight.151281) (PMID:35192549) (PMCID:PMC9057592)
Camargo da Rosa, L. , Scales, H. E. , Makhija, S., Sutherland, K., Benson, R. A. , Brewer, J. M. and Garside, P. (2022) Revealing stromal and lymphoid sources of Col3a1-expression during inflammation using a novel reporter mouse. Discovery Immunology, 1(1), kyac008. (doi: 10.1093/discim/kyac008)
Meehan, G. R. , Scales, H. E. , McInnes, I. B. , Brewer, J. M. and Garside, P. (2022) Orally administered antigen can reduce or exacerbate pathology in an animal model of inflammatory arthritis dependent upon the timing of administration. Immunotherapy Advances, 2(1), ltac020. (doi: 10.1093/immadv/ltac020) (PMID:36268500) (PMCID:PMC9579813)
Girard, A. et al. (2021) Raman spectroscopic analysis of skin as a diagnostic tool for Human African Trypanosomiasis. PLoS Pathogens, 17(11), e1010060. (doi: 10.1371/journal.ppat.1010060) (PMID:34780575) (PMCID:PMC8629383)
Meehan, G. R. et al. (2021) Preclinical models of arthritis for studying immunotherapy and immune tolerance. Annals of the Rheumatic Diseases, 80(10), pp. 1268-1277. (doi: 10.1136/annrheumdis-2021-220043) (PMID:34380700)
Raponi, A., Brewer, J. M. , Garside, P. and Laera, D. (2021) Nanoalum adjuvanted vaccines: small details make a big difference. Seminars in Immunology, 56, 101544. (doi: 10.1016/j.smim.2021.101544) (PMID:34895823)
Bonilha, C. S., Benson, R. A. , Scales, H. E. , Brewer, J. M. and Garside, P. (2021) Junctional adhesion molecule-A on dendritic cells regulates Th1 differentiation. Immunology Letters, 235, pp. 32-40. (doi: 10.1016/j.imlet.2021.05.001) (PMID:34000305)
Al Khabouri, S., Benson, R. A. , Prendergast, C. T., Gray, J. I., Otto, T. D. , Brewer, J. M. and Garside, P. (2021) TCRß sequencing reveals spatial and temporal evolution of clonal CD4 T cell responses in a breach of tolerance model of inflammatory arthritis. Frontiers in Immunology, 12, 669856. (doi: 10.3389/fimmu.2021.669856) (PMID:33986757) (PMCID:PMC8110912)
Gray, J. I. et al. (2021) Tolerance induction in memory CD4 T cells is partial and reversible. Immunology, 162(1), pp. 68-83. (doi: 10.1111/imm.13263) (PMID:32931017) (PMCID:PMC7730012)
Bonilha, C. S., Benson, R. A. , Brewer, J. M. and Garside, P. (2020) Targeting opposing immunological roles of the junctional adhesion molecule-A in autoimmunity and cancer. Frontiers in Immunology, 11, 602094. (doi: 10.3389/fimmu.2020.602094) (PMID:33324419) (PMCID:PMC7723963)
Osii, R. S., Otto, T. D. , Garside, P. , Ndungu, F. and Brewer, J. M. (2020) The impact of malaria parasites on dendritic cell–T cell interaction. Frontiers in Immunology, 11, 1597. (doi: 10.3389/fimmu.2020.01597)
Alfituri, O. A., Quintana, J. F. , MacLeod, A. , Garside, P. , Benson, R. A. , Brewer, J. M., Mabbott, N. A., Morrison, L. J. and Capewell, P. (2020) To the skin and beyond: the immune response to African trypanosomes as they enter and exit the vertebrate host. Frontiers in Immunology, 11, 1250. (doi: 10.3389/fimmu.2020.01250) (PMID:32595652) (PMCID:PMC7304505)
Meehan, G. R. , Scales, H. E. , Osii, R., De Niz, M., Lawton, J. C., Marti, M. , Garside, P. , Craig, A. and Brewer, J. M. (2020) Developing a xenograft model of human vasculature in the mouse ear pinna. Scientific Reports, 10, 2058. (doi: 10.1038/s41598-020-58650-y) (PMID:32029768) (PMCID:PMC7004987)
MacRitchie, N. et al. (2020) The aorta can act as site of naïve CD4+ T cell priming. Cardiovascular Research, 116(2), pp. 306-316. (doi: 10.1093/cvr/cvz102) (PMID:30980670)
Noonan, J., Grassia, G., MacRitchie, N., Garside, P. , Guzik, T. J., Bradshaw, A. C. and Maffia, P. (2019) A novel triple-cell two-dimensional model to study immune-vascular interplay in atherosclerosis. Frontiers in Immunology, 10, 849. (doi: 10.3389/fimmu.2019.00849) (PMID:31068936) (PMCID:PMC6491724)
Hayes, A. J. et al. (2019) Spatiotemporal modeling of the key migratory events during the initiation of adaptive immunity. Frontiers in Immunology, 10, 598. (doi: 10.3389/fimmu.2019.00598) (PMID:31024523) (PMCID:PMC6460458)
Alfituri, O. A., Ajibola, O., Brewer, J. M. , Garside, P. , Benson, R. A. , Peel, T., Morrison, L. J. and Mabbott, N. A. (2019) Effects of host-derived chemokines on the motility and viability of Trypanosoma brucei. Parasite Immunology, 41(2), e12609. (doi: 10.1111/pim.12609) (PMID:30525202) (PMCID:PMC6767366)
Capewell, P. et al. (2019) Resolving the apparent transmission paradox of African sleeping sickness. PLoS Biology, 17(1), e3000105. (doi: 10.1371/journal.pbio.3000105) (PMID:30633739) (PMCID:PMC6345479)
Scales, H. E. et al. (2018) A novel cellular pathway of antigen presentation and CD4 T cell activation in vivo. Frontiers in Immunology, 9, 2684. (doi: 10.3389/fimmu.2018.02684)
Benson, R. A. et al. (2018) Non-invasive multiphoton imaging of islets transplanted into the pinna of the NOD mouse ear reveals the immediate effect of anti-CD3 treatment in autoimmune diabetes. Frontiers in Immunology, 9, 1006. (doi: 10.3389/fimmu.2018.01006) (PMID:29867981) (PMCID:PMC5968092)
Prendergast, C. T., Patakas, A., Al-Khabouri, S., McIntyre, C. L., McInnes, I. B. , Brewer, J. M. , Garside, P. and Benson, R. A. (2018) Visualising the interaction of CD4 T cells and DCs in the evolution of inflammatory arthritis. Annals of the Rheumatic Diseases, 77(4), pp. 579-588. (doi: 10.1136/annrheumdis-2017-212279) (PMID:29358281)
Benson, R. A. , McInnes, I. B. , Garside, P. and Brewer, J. M. (2018) Model answers: rational application of murine models in Arthritis research. European Journal of Immunology, 48(1), pp. 32-38. (doi: 10.1002/eji.201746938) (PMID:29193037) (PMCID:PMC5814907)
MacRitchie, N., Grassia, G., Noonan, J., Garside, P. , Graham, D. and Maffia, P. (2018) Molecular imaging of atherosclerosis: spotlight on Raman spectroscopy and surface-enhanced Raman scattering. Heart, 104(6), pp. 460-467. (doi: 10.1136/heartjnl-2017-311447) (PMID:29061690) (PMCID:PMC5861389)
Noonan, J. et al. (2018) In vivo multiplex molecular imaging of vascular inflammation using surface-enhanced Raman spectroscopy. Theranostics, 8(22), pp. 6195-6209. (doi: 10.7150/thno.28665) (PMID:30613292) (PMCID:PMC6299693)
Jaigrdar, S. A., Benson, R. A. , Elmesmari, A., Kurowska-Stolarska, M. S. , McInnes, I. B. , Garside, P. and Macleod, M. K.L. (2017) Sphingosine-1-phosphate promotes the persistence of activated CD4 T cells in inflamed sites. Frontiers in Immunology, 8, 1627. (doi: 10.3389/fimmu.2017.01627) (PMID:29225602) (PMCID:PMC5705559)
Stephen, J., Scales, H.E. , Benson, R.A. , Erben, D., Garside, P. and Brewer, J.M. (2017) Neutrophil swarming and extracellular trap formation play a significant role in Alum adjuvant activity. npj Vaccines, 2, 1. (doi: 10.1038/s41541-016-0001-5) (PMID:29263862) (PMCID:PMC5604741)
Capewell, P. et al. (2016) The skin is a significant but overlooked anatomical reservoir for vector-borne African trypanosomes. eLife, 5, e17716. (doi: 10.7554/eLife.17716) (PMID:27653219) (PMCID:PMC5065312)
Cosway, E., Anderson, G., Garside, P. and Prendergast, C. (2016) The thymus and rheumatology: should we care? Current Opinion in Rheumatology, 28(2), pp. 189-195. (doi: 10.1097/bor.0000000000000251) (PMID:26751840) (PMCID:PMC4732010)
Patakas, A., Ji, R., Weir, W. , Connolly, S. E., Benson, R. A. , Nadler, S. G., Brewer, J. M. , McInnes, I. B. and Garside, P. (2016) Abatacept inhibits T cell priming by inducing of a unique transcriptional profile that reduces their ability to activate antigen presenting cells. Arthritis and Rheumatology, 68(3), pp. 627-638. (doi: 10.1002/art.39470) (PMID:26473409)
Scales, H. E. , Ierna, M., Smith, K. M., Ross, K., Meiklejohn, G. R., Patterson-Kane, J. C., McInnes, I. B., Brewer, J. M. , Garside, P. and Maffia, P. (2016) Assessment of murine collagen-induced arthritis by longitudinal non-invasive duplexed molecular optical imaging. Rheumatology, 55(3), pp. 564-572. (doi: 10.1093/rheumatology/kev361) (PMID:26475798)
Benson, R. A. , Macleod, M. K.L. , Hale, B. G.H. , Patakas, A., Garside, P. and Brewer, J. M. (2015) Antigen presentation kinetics control T cell/dendritic cell interactions and follicular helper T cell generation in vivo. eLife, 4, e06994. (doi: 10.7554/eLife.06994) (PMID:26258879) (PMCID:PMC4558563)
Hawkins, P., Armstrong, R., Boden, T., Garside, P. , Knight, K., Lilley, E., Seed, M., Wilkinson, M. and Williams, R. O. (2015) Applying refinement to the use of mice and rats in rheumatoid arthritis research. Inflammopharmacology, 23(4), pp. 131-150. (doi: 10.1007/s10787-015-0241-4) (PMID:26168847) (PMCID:PMC4508365)
Hu, D. et al. (2015) Artery tertiary lymphoid organs control aorta immunity and protect against atherosclerosis via vascular smooth muscle cell lymphotoxin β receptors. Immunity, 42(6), pp. 1100-1115. (doi: 10.1016/j.immuni.2015.05.015) (PMID:26084025) (PMCID:PMC4678289)
Benson, R. A. , McInnes, I. B. , Brewer, J. M. and Garside, P. (2015) Cellular imaging in rheumatic diseases. Nature Reviews Rheumatology, 11(6), pp. 357-367. (doi: 10.1038/nrrheum.2015.34) (PMID:25800215)
Oliver-Bell, J., Butcher, J.P., Malcolm, J. , Macleod, M.K.L. , Adrados Planell, A., Campbell, L., Nibbs, R.J.B. , Garside, P. , McInnes, I.B. and Culshaw, S. (2015) Periodontitis in the absence of B cells and specific anti-bacterial antibody. Oral Microbiology and Immunology, 30(2), pp. 160-169. (doi: 10.1111/omi.12082) (PMID:25219939)
Platt, A. M., Benson, R. A. , McQueenie, R., Butcher, J. P., Braddock, M., Brewer, J. M. , McInnes, I. B. and Garside, P. (2015) The active metabolite of spleen tyrosine kinase inhibitor fostamatinib abrogates the CD4+ T cell-priming capacity of dendritic cells. Rheumatology, 54(1), pp. 169-177. (doi: 10.1093/rheumatology/keu273) (PMID:25065010)
Lawton, J. C., Benson, R. A. , Garside, P. and Brewer, J. M. (2014) Using lymph node transplantation as an approach to image cellular interactions between the skin and draining lymph nodes during parasitic infections. Parasitology International, 63(1), pp. 165-170. (doi: 10.1016/j.parint.2013.07.010)
David, A., Crawford, F., Garside, P. , Kappler, J. W., Marrack, P. and Macleod, M. (2014) Tolerance induction in memory CD4 T cells requires two rounds of antigen-specific activation. Proceedings of the National Academy of Sciences of the United States of America, 111(21), pp. 7735-7740. (doi: 10.1073/pnas.1406218111) (PMID:24821788) (PMCID:PMC4040609)
Maddaluno, M., MacRitchie, N., Grassia, G., Ialenti, A., Butcher, J. P., Garside, P. , Brewer, J. M. and Maffia, P. (2014) Murine aortic smooth muscle cells acquire, though fail to present exogenous protein antigens on major histocompatibility complex class II molecules. BioMed Research International(949845), (doi: 10.1155/2014/949845) (PMID:25136640) (PMCID:PMC4127268)
Grassia, G., MacRitchie, N., Platt, A., Brewer, J. , Garside, P. and Maffia, P. (2013) Plasmacytoid dendritic cells: biomarkers or potential therapeutic targets in atherosclerosis? Pharmacology and Therapeutics, 137(2), pp. 172-182. (doi: 10.1016/j.pharmthera.2012.10.001) (PMID:23059425)
MacRitchie, N. et al. (2012) Plasmacytoid dendritic cells play a key role in promoting atherosclerosis in apolipoprotein e-deficient mice. Arteriosclerosis, Thrombosis, and Vascular Biology, 32(11), pp. 2569-2579. (doi: 10.1161/ATVBAHA.112.251314)
Patakas, A., Benson, R.A. , Withers, D.R., Conigliaro, P., McInnes, I.B. , Brewer, J.M. and Garside, P. (2012) Th17 effector cells support B bell responses outside of germinal centres. PLoS ONE, 7(11), e49715. (doi: 10.1371/journal.pone.0049715) (PMID:23166752) (PMCID:PMC3500323)
Gibson, V.B. et al. (2012) A novel method to allow noninvasive, longitudinal imaging of the murine immune system in vivo. Blood, 119(11), pp. 2545-2551. (doi: 10.1182/blood-2011-09-378356) (PMID:22271449) (PMCID:PMC3398133)
Ghimire, T.R., Benson, R.A. , Garside, P. and Brewer, J.M. (2012) Alum increases antigen uptake, reduces antigen degradation and sustains antigen presentation by DCs in vitro. Immunology Letters, 147(1-2), pp. 55-62. (doi: 10.1016/j.imlet.2012.06.002)
Hutchison, S., Benson, R.A. , Gibson, V.B., Pollock, A.H., Garside, P. and Brewer, J.M. (2012) Antigen depot is not required for alum adjuvanticity. FASEB Journal, 26(3), pp. 1272-1279. (doi: 10.1096/fj.11-184556) (PMID:22106367) (PMCID:PMC3289510)
McQueenie, R., Stevenson, R., Benson, R. , MacRitchie, N., McInnes, I. , Maffia, P. , Faulds, K., Graham, D., Brewer, J. and Garside, P. (2012) Detection of inflammation in vivo by surface-enhanced raman scattering provides higher sensitivity than conventional fluorescence imaging. Analytical Chemistry, 84(14), pp. 5968-5975. (doi: 10.1021/ac3006445)
Patakas, A., Benson, R.A. , Withers, D.R., Conigliaro, P., McInnes, I.B. , Brewer, J.M. and Garside, P. (2012) Th17 effector cells support B cell responses outside of germinal centres. PLoS ONE, 7(11), e49715. (doi: 10.1371/journal.pone.0049715) (PMID:23161902) (PMCID:PMC3812864)
Vincent, T.L., Williams, R.O., Maciewicz, R., Silman, A. and Garside, P. (2012) Mapping pathogenesis of arthritis through small animal models. Rheumatology, 51(11), pp. 1931-1941. (doi: 10.1093/rheumatology/kes035)
Wenink, M.H., Santegoets, K.C.M., Platt, A.M., van den Berg, W.B., van Riel, P.L.C.M., Garside, P. , Radstake, T.R.D.J. and McInnes, I.B. (2012) Abatacept modulates proinflammatory macrophage responses upon cytokine-activated T cell and Toll-like receptor ligand stimulation. Annals of the Rheumatic Diseases, 71(1), pp. 80-83. (doi: 10.1136/annrheumdis-2011-200348) (PMID:21908454)
Benson, R.A. , Patakas, A., McQueenie, R., Ross, K., McInnes, I.B. , Brewer, J.M. and Garside, P. (2011) Arthritis in space and time – to boldly go! FEBS Letters, 585(23), pp. 2640-3648. (doi: 10.1016/j.febslet.2011.04.069) (PMID:21570969)
Lee, K. M. et al. (2011) D6 facilitates cellular migration and fluid flow to lymph nodes by suppressing lymphatic congestion. Blood, 118(23), pp. 6220-6229. (doi: 10.1182/blood-2011-03-344044)
Butcher, J.P., Malcolm, J. , Benson, R.A. , Deng, D.M., Brewer, J.M. , Garside, P. and Culshaw, S. (2011) Effects of streptococcus mutans on dendritic cell activation and function. Journal of Dental Research, 90(10), pp. 1221-1227. (doi: 10.1177/0022034511412970)
Conigliaro, P., Benson, R. A. , Patakas, A., Kelly, S. M., Valesini, G., Holmdahl, R., Brewer, J. M. , McInnes, I. B. and Garside, P. (2011) Characterization of the anticollagen antibody response in a new model of chronic polyarthritis. Arthritis and Rheumatism, 63(8), pp. 2299-2308. (doi: 10.1002/art.30413) (PMID:21506101)
Patakas, A., Platt, A. M., Butcher, J. P., Maffia, P. , McInnes, I. B. , Brewer, J. M. , Garside, P. and Benson, R. A. (2011) Putative existence of reciprocal dialogue between Tfh and B cells and its impact on infectious and autoimmune disease. Immunology Letters, 138(1), pp. 38-46. (doi: 10.1016/j.imlet.2011.03.002) (PMID:21419798)
Fumagalli, S. et al. (2011) In vivo real-time multiphoton imaging of t lymphocytes in the mouse brain after experimental stroke. Stroke, 42(5), pp. 1429-1436. (doi: 10.1161/STROKEAHA.110.603704)
Kollias, G. et al. (2011) Animal models for arthritis: innovative tools for prevention and treatment. Annals of the Rheumatic Diseases, 70(8), pp. 1357-1362. (doi: 10.1136/ard.2010.148551)
Platt, A. M., Gibson, V. B., Patakas, A., Benson, R. A. , Nadler, S. G., Brewer, J. M. , McInnes, I. and Garside, P. (2010) Abatacept limits breach of self-tolerance in a Murine model of arthritis via effects on the generation of T follicular helper cells. Journal of Immunology, 185(3), pp. 1558-1567. (doi: 10.4049/jimmunol.1001311) (PMID:20601593)
Benson, R.A. , Patakas, A., Conigliaro, P., Rush, C. M., Garside, P. , McInnes, I. B. and Brewer, J. M. (2010) Identifying the Cells Breaching Self-Tolerance in Autoimmunity. Journal of Immunology, 184(11), pp. 6378-6385. (doi: 10.4049/jimmunol.0903951) (PMID:20421640)
Rush, C.M., Mitchell, T.J. and Garside, P. (2010) A detailed characterisation of the distribution and presentation of DNA vaccine encoded antigen. Vaccine, 28(6), pp. 1620-1634. (doi: 10.1016/j.vaccine.2009.11.014)
Ortolano, F., Maffia, P. , Dever, G., Rodolico, G. , Millington, O.R., De Simoni, M.G., Brewer, J.M. , Bushell, T.J., Garside, P. and Carswell, H.V. (2010) Advances in imaging of new targets for pharmacological intervention in stroke: real-time tracking of T-cells in the ischaemic brain. British Journal of Pharmacology, 159(4), pp. 808-811. (doi: 10.1111/j.1476-5381.2009.00527.x) (PMID:20015295) (PMCID:PMC2829206)
Conigliaro, P., Perricone, C., Benson, R.A. , Garside, P. , Brewer, J.M. , Perricone, R. and Valesini, G. (2010) The type I IFN system in rheumatoid arthritis. Autoimmunity, 43(3), pp. 220-225. (doi: 10.3109/08916930903510914)
Garside, P. and Brewer, J. (2010) In vivo imaging of infection immunology—4I’s! Seminars in Immunopathology, 32(3), pp. 289-296. (doi: 10.1007/s00281-010-0215-y)
Ortolano, F. et al. (2009) Imaging T-cell movement in the brain during experimental cerebral malaria. Parasite Immunology, 31(3), 147-150 (4). (doi: 10.1111/j.1365-3024.2008.01090.x)
Jongbloed, S.L., Benson, R. , Nickdel, M.B., Garside, P. , McInnes, I. and Brewer, J.M. (2009) Plasmacytoid dendritic cells regulate breach of self-tolerance in autoimmune arthritis. Journal of Immunology, 182(2), pp. 963-968. (doi: 10.4049/jimmunol.182.2.963) (PMID:19124739)
Hueber, A., Stevenson, R., Stokes, R., Graham, D., Garside, P. and McInnes, I. (2009) Imaging inflammation in real time-future of nanoparticles. Autoimmunity, 42(4), pp. 368-372. (doi: 10.1080/08916930902832298) (PMID:19811304)
Hutchison, S., Choo-Kang, B.S.W., Gibson, V.B., Bundick, R.V., Leishman, A.J., Brewer, J.M., McInnes, I. and Garside, P. (2009) An investigation of the impact of the location and timing of antigen-specific T cell division on airways inflammation. Clinical and Experimental Immunology, 155(1), pp. 107-116. (doi: 10.1111/j.1365-2249.2008.03800.x) (PMID:19076834)
Nickdel, M.B., Conigliaro, P., Valesini, G., Hutchison, S., Benson, R. , Bundick, R.V., Leishman, A.J., McInnes, I. , Brewer, J.M. and Garside, P. (2009) Dissecting the contribution of innate and antigen-specific pathways to the breach of self-tolerance observed in a murine model of arthritis. Annals of the Rheumatic Diseases, 68(6), pp. 1059-1066. (doi: 10.1136/ard.2008.089300) (PMID:18635595)
Rush, C.M., Millington, O.R., Hutchison, S., Bryson, K., Brewer, J.M. and Garside, P. (2009) Characterization of CD4+ T-cell-dendritic cell interactions during secondary antigen exposure in tolerance and priming. Immunology, 128(4), pp. 463-471. (doi: 10.1111/j.1365-2567.2009.03124.x)
Thompson, J., Millington, O.R., Garside, P. and Brewer, J.M. (2008) What can transgenic parasites tell us about the development of Plasmodium-specific immune responses? Parasite Immunology, 30(4), pp. 223-233. (doi: 10.1111/j.1365-3024.2007.01011.x) (PMID:18324925)
Marshall, F. A., Watson, K. A., Garside, P. , Harnett, M. M. and Harnett, W. (2008) Effect of activated antigen-specific B cells on ES-62-mediated modulation of effector function of heterologous antigen-specific T cells in vivo. Immunology, 123(3), pp. 411-425. (doi: 10.1111/j.1365-2567.2007.02706.x)
Garside, P. and Brewer, J. M. (2008) Real-time imaging of the cellular interactions underlying tolerance, priming, and responses to infection. Immunological Reviews, 221(1), pp. 130-146. (doi: 10.1111/j.1600-065X.2008.00587.x) (PMID:18275479)
Hutchison, S., Choo-Kang, B.S.W., Bundick, R.V., Leishman, A.J., Brewer, J.M., McInnes, I. and Garside, P. (2008) Tumour necrosis factor-alpha blockade suppresses murine allergic airways inflammation. Clinical and Experimental Immunology, 151(1), pp. 114-122. (doi: 10.1111/j.1365-2249.2007.03509.x) (PMID:17931392)
Millington, O.R., Zinselmeyer, B.H., Brewer, J.M. , Garside, P. and Rush, C.M. (2007) Lymphocyte tracking and interactions in secondary lymphoid organs. Inflammation Research, 56(10), pp. 391-401. (doi: 10.1007/s00011-007-7017-2) (PMID:18026695)
Maffia, P. , Zinselmeyer, B.H., Ialenti, A., Kennedy, S. , Baker, A.H., McInnes, I., Brewer, J.M. and Garside, P. (2007) Multiphoton microscopy for 3-dimensional imaging of lymphocyte recruitment into apolipoprotein-E-deficient mouse carotid artery. Circulation, 115(11), E326-E328. (doi: 10.1161/CIRCULATIONAHA.106.658492) (PMID:17372180)
Millington, O.R., Gibson, V.B., Rush, C.M., Zinselmeyer, B.H., Phillips, R.S., Garside, P. and Brewer, J.M. (2007) Malaria impairs T cell clustering and immune priming despite normal signal 1 from dendritic cells. PLoS Pathogens, 3(10), e143. (doi: 10.1371/journal.ppat.0030143)
Maffia, P. , Grassia, G., Di Meglio, P., Carnuccio, R., Berrino, L., Garside, P. , Ianaro, A. and Ialenti, A. (2006) Neutralization of interleukin-18 inhibits neointimal formation in a rat model of vascular injury. Circulation, 114, pp. 430-437. (doi: 10.1161/CIRCULATIONAHA.105.602714) (PMID:16864728)
Ierna, M. X., Scales, H. E. , Schwarz, H., Bunce, C., McIlgorm, A., Garside, P. and Lawrence, C. E. (2006) OX40 interactions in gastrointestinal nematode infection. Immunology, 117(1), pp. 108-116. (doi: 10.1111/j.1365-2567.2005.02271.x) (PMID:16423046)
Duffy, D., Yang, C., Heath, A., Garside, P. and Bell, E. (2006) Naive T-cell receptor transgenic T cells help memory B cells produce antibody. Immunology, 119, pp. 376-384. (doi: 10.1111/j.1365-2567.2006.02446.x)
Rush, C., Mitchell, T., Burke, B. and Garside, P. (2006) Dissecting the components of the humoral immune response elicited by DNA vaccines. Vaccine, 24, pp. 776-784. (doi: 10.1016/j.vaccine.2005.08.080)
Schneider, H., Downey, J., Smith, A., Zinselmeyer, B., Rush, C., Brewer, J., Wei, B., Hogg, N., Garside, P. and Rudd, C. (2006) Reversal of the TCR stop signal by CTLA-4. Science, 313, pp. 1972-1975. (doi: 10.1126/science.1131078)
Smith, K., Garside, P., Mcneil, R. and Brewer, J. (2006) Analysis of costimulatory molecule expression on antigen-specific T and B cells during the induction of adjuvant-induced Th1 and Th2 type responses. Vaccine, 24, pp. 3035-3043. (doi: 10.1016/j.vaccine.2005.10.027)
Yang, C., Sparshott, S., Duffy, D., Garside, P. and Bell, E. (2006) The phenotype and survival of antigen-stimulated transgenic CD4 T cells in vivo: the influence of persisting antigen. International Immunology, 18, pp. 515-523. (doi: 10.1093/intimm/dxh392)
Boitelle, A., Di Lorenzo, C., Scales, H.E. , Devaney, E. , Kennedy, M.W., Garside, P. and Lawrence, C.E. (2005) Contrasting effects of acute and chronic gastro-intestinal helminth infections on a heterologous immune response in a transgenic adoptive transfer model. International Journal for Parasitology, 35(7), pp. 765-775. (doi: 10.1016/j.ijpara.2005.02.013) (PMID:15893319)
Millington, O. R., Di Lorenzo, C., Phillips, R. S., Garside, P. and Brewer, J. M. (2005) Suppression of adaptive immunity to heterologous antigens during Plasmodium infection through hemozoin-induced failure of dendritic cell function. Journal of Biology, 5, 5. (doi: 10.1186/jbiol34) (PMID:16611373) (PMCID:PMC1561486)
Choo-Kang, B., Hutchison, S., Nickdel, M., Bundick, R., Leishman, A., Brewer, J., McInnes, I. and Garside, P. (2005) TNF-blocking therapies: an alternative mode of action? Trends in Immunology, 26, pp. 518-522. (doi: 10.1016/j.it.2005.07.007) (PMID:16087401)
Grierson, A., Mitchell, P., Adams, C., Mowat, A., Brewer, J., Harnett, M. and Garside, P. (2005) Direct quantitation of T cell signaling by laser scanning cytometry. Journal of Immunological Methods, 301, pp. 140-153. (doi: 10.1016/j.jim.2005.04.011)
Kerr, A., Kirkham, L., Kadioglu, A., Andrew, P., Garside, P., Thompson, H. and Mitchell, T. (2005) Identification of a detrimental role for NK cells in pneumococcal pneumonia and sepsis in immunocompromised hosts. Microbes and Infection, 7, pp. 845-852. (doi: 10.1016/j.mincinf.2005.02.011)
Marshall, F., Grierson, A., Garside, P., Harnett, W. and Harnett, M. (2005) ES-62, an immunomodulator secreted by filarial nematodes, suppresses clonal expansion and modifies effector function of heterologous antigen-specific T cells in vivo. Journal of Immunology, 175, pp. 5817-5826.
Mirenda, V., Millington, O., Lechler, R., Scott, D., Hernandez-Fuentes, M., Read, J., Tan, P., George, A., Garside, P. and Marelli-Berg, F. (2005) Tolerant T cells display impaired trafficking ability. European Journal of Immunology, 35, pp. 2146-2156. (doi: 10.1002/eji.200425823)
Zinselmeyer, B. H. et al. (2005) In situ characterization of CD4+ T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance. Journal of Experimental Medicine, 201(11), pp. 1815-1823. (doi: 10.1084/jem.20050203)
Zinselmeyer, B. et al. (2005) In situ characterization of CD4(+) T cell behavior in mucosal and systemic lymphoid tissues during the induction of oral priming and tolerance. Journal of Experimental Medicine, 201, pp. 1815-1823. (doi: 10.1084/jem.20050203)
Scales, H. E. , Ierna, M. X., Gutierrez-Ramos, J.-C., Coyle, A. J., Garside, P. and Lawrence, C. E. (2004) Effect of inducible costimulator blockade on the pathological and protective immune responses induced by the gastrointestinal helminth Trichinella spiralis. European Journal of Immunology, 34, pp. 2854-2862. (doi: 10.1002/eji.200324364) (PMID:5368302)
Smith, K. M., Brewer, J. M. , Rush, C. M., Riley, J. and Garside, P. (2004) In vivo generated Th1 cells can migrate to B cell follicles to support B cell responses. Journal of Immunology, 173(3), pp. 1640-1646. (doi: 10.4049/jimmunol.173.3.1640) (PMID:15265892)
Maffia, P. , Brewer, J. M. , Gracie, J. A., Ianaro, A., Leung, B. P., Mitchell, P. J., Smith, K. M., McInnes, I. B. and Garside, P. (2004) Inducing experimental arthritis and breaking self-tolerance to joint-specific antigens with trackable, ovalbumin-specific T cells. Journal of Immunology, 173(1), pp. 151-156. (doi: 10.4049/jimmunol.173.1.151) (PMID:15210769)
Adams, C., Grierson, A., Mowat, A., Harnett, M. and Garside, P. (2004) Differences in the kinetics, amplitude, and localization of ERK activation in anergy and priming revealed at the level of individual primary T cells by laser scanning cytometry. Journal of Immunology, 173, pp. 1579-1586.
Adams, C., Kobets, N., Meiklejohn, G., Millington, O., Grierson, A., Rush, C., Smith, K. and Garside, P. (2004) Tracking lymphocytes in vivo. Archivum Immunologiae et Therapiae Experimentalis, 52, pp. 173-187.
Garside, P., Millington, O. and Smith, K. (2004) The anatomy of mucosal immune responses. Oral Tolerance, 1029, pp. 9-15. (doi: 10.1196/annals.1309.002)
Kobets, N., Kennedy, K., O'Donnell, D. and Garside, P. (2004) An investigation of the ability of orally primed and tolerised T cells to help B cells upon mucosal challenge. Immunology, 112, pp. 550-558. (doi: 10.1046/j.1365-2567.2004.01913.x)
Millington, O., Mowat, A. and Garside, P. (2004) Induction of bystander suppression by feeding antigen occurs despite normal clonal expansion of the bystander T cell population. Journal of Immunology, 173, pp. 6059-6064.
Millington, O., Wei, X., Garside, P. and Mowat, A. (2004) Interleukin-15 is not required for the induction or maintenance of orally induced peripheral tolerance. Immunology, 113, pp. 304-309. (doi: 10.1111/j.1365-2567.2004.01965.x)
Smith, K., Brewer, J., Mowat, A., Ron, Y. and Garside, P. (2004) The influence of follicular migration on T-cell differentiation. Immunology, 111, pp. 248-251. (doi: 10.1111/j.1365-2567.2004.01813.x)
Boitelle, A., Scales, H. E. , Di Lorenzo, C., Devaney, E. , Kennedy, M. W. , Garside, P. and Lawrence, C. E. (2003) Investigating the impact of helminth products on immune responsiveness using a TCR transgenic adoptive transfer system. Journal of Immunology, 171(1), pp. 447-454. (doi: 10.4049/jimmunol.171.1.447) (PMID:12817029)
Smith, K. M., Brewer, J. M. , Webb, P., Coyle, A. J., Gutierrez-Ramos, C. and Garside, P. (2003) Inducible costimulatory molecule-B7-related protein 1 interactions are important for the clonal expansion and B cell helper functions of naive, Th1, and Th2 T cells. Journal of Immunology, 170(5), pp. 2310-2315. (doi: 10.4049/jimmunol.170.5.2310) (PMID:12594252)
Adams, C. L., Macleod, M. K.L. , Milner-White, E. J., Aitken, R., Garside, P. and Stott, D.I. (2003) Complete analysis of the B-cell response to a protein antigen, from in vivo germinal centre formation to 3-D modelling of affinity maturation. Immunology, 108(3), pp. 274-287. (doi: 10.1046/j.1365-2567.2003.01583.x) (PMID:12603593)
Eaton, A., Xu, D. and Garside, P. (2003) Administration of exogenous interleukin-18 and interleukin-12 prevents the induction of oral tolerance. Immunology, 108, pp. 196-203.
Kobets, N., Kennedy, K. and Garside, P. (2003) An investigation of the distribution of antigen fed in tolerogenic or immunogenic forms. Immunology Letters, 88, pp. 147-155. (doi: 10.1016/S0165-2478(03)00076-2)
Rush, C., Mitchell, T. and Garside, P. (2002) Efficient priming of CD4(+) and CD8(+) T cells by DNA vaccination depends on appropriate targeting of sufficient levels of immunologically relevant antigen to appropriate processing pathways. Journal of Immunology, 169, pp. 4951-4960.
Smith, K., Davidson, J. and Garside, P. (2002) T-cell activation occurs simultaneously in local and peripheral lymphoid tissue following oral administration of a range of doses of immunogenic or tolerogenic antigen although tolerized T cells display a defect in cell division. Immunology, 106, pp. 144-158.
Smith, K., McAskill, F. and Garside, P. (2002) Orally tolerized T cells are only able to enter B cell follicles following challenge with antigen in adjuvant, but they remain unable to provide B cell help. Journal of Immunology, 168, pp. 4318-4325.
Garside, P. and Mowat, A. (2001) Oral tolerance. Seminars in Immunology, 13, pp. 177-185. (doi: 10.1006/smim.2001.0310)
Smith, K., Pottage, L., Thomas, E., Leishman, A., Doig, T., Xu, D., Liew, F. and Garside, P. (2000) Th1 and Th2CD4(+) T cells provide help for B cell clonal expansion and antibody synthesis in a similar manner in vivo. Journal of Immunology, 165(6), pp. 3136-3144.
Taylor-Robinson, A. W., Liew, F. Y., Severn, A., Xu, D., McSorley, S. J., Garside, P. , Padron, J. and Phillips, R. S. (1994) Regulation of the immune response by nitric oxide differentially produced by T helper type 1 and T helper type 2 cells. European Journal of Immunology, 24(4), pp. 980-984. (doi: 10.1002/eji.1830240430) (PMID:8149966)
Book Sections
Benson, R. A. , Brewer, J. M. and Garside, P. (2017) Visualizing and tracking T cell motility In vivo. In: Rainger, G. E. and Mcgettrick, H. M. (eds.) T-Cell Trafficking: Methods and Protocols [Second Edition]. Series: Methods in molecular biology (1591). Springer: New York, pp. 27-41. ISBN 9781493969296 (doi: 10.1007/978-1-4939-6931-9_3)
Millington, O. R., Brewer, J. M. , Garside, P. and Maffia, P. (2010) Imaging interactions between the immune and cardiovascular systems in vivo by multiphoton microscopy. In: Marelli-Berg, F. M. and Nourshargh, S. (eds.) T-Cell Trafficking: Methods and Protocols. Series: Methods in Molecular Biology, 616 (616). Humana Press Inc, pp. 193-206. ISBN 9781607614609 (doi: 10.1007/978-1-60761-461-6_13)
Conference Proceedings
De Simoni, M.G., Fumagalli, S., Ortolano, F., Maffia, P. , Carswell, H.C. and Garside, P. (2010) In vivo blood flow dynamics after focal ischemia in mice. In: International Stroke Conference 2010, San Antonio, TX, 23-26 Feb 2010, e225. (doi: 10.1161/01.str.0000366114.11305.66)
Grassia, G., Dever, G., Gordon, P., McInnes, I. , Spanbroek, R., Habenicht, A.J.R., Brewer, J. , Garside, P. and Maffia, P. (2010) Real time imaging of lymphocytes in APOE-/- mouse aortic tertiary lymphoid organs. In: Spring Meeting of the British-Society-for-Cardiovascular-Research 2010, Manchester, UK, 07-08 June 2010, e12. (doi: 10.1136/hrt.2010.205781.11)
Dever, G., Rodolico, G., Berrino, L., McInnes, I. , Brewer, J. , Garside, P. and Maffia, P. (2009) Three dimensional imaging of atherosclerotic plaques in apolipoprotien e-deficient mice. In: Spring Meeting of the British-Society-for-Cardiovascular-Research 2009, Oxford, Uk, 02-04 Apr 2009, (doi: 10.1136/hrt.2009.178137i)
Dever, G., Rodolico, G., Liberato, B., McInnes, I. , Brewer, J. , Garside, P. and Maffia, P. (2009) Confocal and multiphoton laser scanning microscopy provide 3-dimensional imaging of atherosclerotic plaques in apolipoprotein E-deficient mice. In: Arteriosclerosis, Thrombosis and Vascular Biology Annual Conference 2009, Washington DC, USA, 29 Apr - 1 May 2009, e74. (doi: 10.1161/ATV.0B013E3181AB66E7)
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- KAMUZU University of Health Sciences Strategic Partnership
Scottish Government
2023 - 2028
- RACE Renewal
Versus Arthritis
2019 - 2024
- Development of nutritional strategies for diabetes prevention in Malawian adults at high diabetes risk
Medical Research Council
2018 - 2019
- Rheuma Tolerance for Cure
European Commission
2017 - 2022
- Blantyre-Blantyre Clinical Research Project
Scottish Government
2017 - 2022
- NanoMATe
European Commission
2015 - 2017
- Integrin-mediated regulation of leukocytes in autoimmunity.
Arthritis Research UK
2015 - 2021
- The Wellcome Centre for Molecular Parasitology ( Core Support )
Wellcome Trust
2014 - 2021
- Genetic Determinants of Trypanotolerance in Humans (ISSF Catalyst)
Wellcome Trust
2014 - 2015
- In Situ Nanoparticle Assemblies for Healthcare Diagnostics and Therapy. Reference: 130479
Engineering and Physical Sciences Research Council
2014 - 2018
- Defining innate and adaptive immune functions of plasmacytoid dendritic cells in atherosclerosis.
British Heart Foundation
2013 - 2017
- Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure)
Arthritis Research UK
2013 - 2019
- Defining the Role of Cell Migration in the Initiation and Regulation of Pathogenesis in Inflammatory Arthritis
Arthritis Research UK
2013 - 2019
- RSE/CRF Biomedical Personal Research Fellowship
The Royal Society of Edinburgh
2012 - 2012
- Transfer of expertise in bioimaging from academia to industry.
Scottish Funding Council
2011 - 2012
- Understanding and manipulating chemokines and their receptors in the context of adjuvants
Biotechnology and Biological Sciences Research Council
2011 - 2014
- Cytoadherence-mediated pathology in cerebral malaria
Wellcome Trust
2011 - 2017
- BTCure
European Commission
2011 - 2017
- Targeting cell contact to reduce autoimmunity and enhance vaccination
Scottish Universities Life Sciences Alliance
2011 - 2012
- Gums and Joints
European Commission
2010 - 2014
- Dissecting differences in joint, tendon sheath and systemic pathology between two murine models of synovial self-tolerance breach: what are the respective roles of T helper-1 and -17 cells?
Wellcome Trust
2010 - 2012
- Regulation of the adaptive immune response by chemokine scavenging receptors
Medical Research Council
2010 - 2015
- In Vivo Reporting using Nanosystems Chemistry and Optical Spectroscopy
Engineering and Physical Sciences Research Council
2010 - 2011
- Investigating the role of T cells in vascular pathology
British Heart Foundation
2010 - 2010
- Investigating the relationship between the cellular interations in inflamed atricular tissues and their draining lymphoid organs during the development of immune responses
Arthritis Research UK
2009 - 2010
- Dissecting the adaptive immune response to cariogenic bacteria in the oral cavity
Medical Research Scotland
2009 - 2010
- Investigating the contributions of antigen targeting and inflammation to adjuvant function
Wellcome Trust
2009 - 2012
- Investigating the contributions of inflammation and antigen depot to adjuvant function in vivo
Biotechnology and Biological Sciences Research Council
2009 - 2010
- T cell signalling events in vivo during the induction of immunity and tolerance
Medical Research Council
2006 - 2009
- Dissecting the roles played by Dendritic cells and T lymphocytes in mediating inflammatory arthropathies
Scottish Executive Health Department
2005 - 2008
- Elucidating immune mechanisms in inflammatory arthritis
Nuffield Foundation
2004 - 2013
- Pharmaplant - Recombinant Pharmaceuticals from Plants for Human Health
European Commission
2004 - 2009
- Revealing the cellular and molecular interactions underlying the development of tolerance or immunity in real time in vivo
Wellcome Trust
2003 - 2005
- Dissecting the mechanisms underlying mucosal DNA vaccination
Wellcome Trust
2003 - 2006
- Dendritic cell function and immune responsiveness in malaria infections
Wellcome Trust
2002 - 2005
- Characterising the role of APC phenotype and activation state in the induction of Th1/Th2 responses in vivo
Biotechnology and Biological Sciences Research Council
2001 - 2005
- Dissection of the Cellular and Molecular Basis of Immunoregulation in Vivo
Medical Research Council
2001 - 2006