School of Cancer Sciences

NCRI Conference 2018

Seth Coffelt won the BACR-AstraZeneca Young Scientist Frank Rose Award. The purpose of the award is to recognise and reward the achievements of an individual whose work has made significant contributions to translational cancer research. To mark the award, Seth gave a talk at the NCRI Cancer Conference in Glasgow in November. A number of others from Glasgow gave talks at the conference including Dr Jen Morton talking about PRECISION-Panc.

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Dr Krishna Yalla and Surbhi Kaul from the ICS Translational Pharmacology Laboratory also gave talks and presented posters at the NCRI Conference.

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Festival of Genomics

Susie Cooke (Head of Medical Genomics, Glasgow Precision Oncology Laboratory, ICS) – gave a talk on Precision Medicine and the Future of Cancer Clinical Genomics at the Festival of Genomics in London on 23rd January. It is the largest genomics event in the UK and features talks on government policy, national healthcare strategy and regulation, as well as the latest research and technology from the NHS, industry, and academia. www.festivalofgenomics.com

Stand Up To Cancer

To raise awareness of the Stand Up To Cancer campaign, Seth Coffelt met with a young woman, Rebecca Scott, who had been diagnosed with ovarian cancer and gave her a tour of the labs. The story was featured in an article in the Glasgow Evening Times (photo credit: Steve Welsh). 

World Pancreatic Cancer Day

On 15th November people at the CRUK Beatson Institute and ICS dressed in purple for World Pancreatic Cancer Day. People also dressed up in pink to support Breast Cancer Now (‘Wear it pink’).

CRUK Beatson International Cancer Conference

The CRUK Beatson International Cancer Conference 2019 (Sunday 30th June - Wednesday 3rd July) is now open for registration, follow the link here: Beatson International Cancer Conference

Autophagy UK Network conference in May 2019

The 5th Annual UK Autophagy Network meeting will be held in the Sir Charles Wilson Building (UofG) on the 21st and 22nd of May 2019
Website Autophagy UK Network
Twitter @autophagyuk

Autophagy is an evolutionarily conserved process where the cells degrade their own cellular material. It is involved in protein and organelle degradation and plays an essential role in both cellular and whole-animal homeostasis. It has become one of the major challenges for research in biology and for the discovery of new therapeutic approaches. At the Institute of Cancer Sciences the Helgason group has been studying autophagy in relation to chronic myeloid leukaemia for a number of years. More information can be found here: Autophagy UK Network Registration open soon

Prof Kevin Ryan: Results of a study on mannose, led by Kevin Ryan, were published in Nature and received a lot of media attention. BBC coverage: Simple sugar supplement 'can slow cancer growth' and Sugary supplement mannose could help fight cancer Press release from CRUK Article

Seth Coffelt is now a member of the Breast Cancer Now Grants Committee.

Krishna Yalla (TPL) has been selected for the MVLS ISSF Summer Scholarships Scheme 2019. As a part of this program, she will design a project, interview and select a 3rd year undergraduate student (Genetics, Immunology, Pharmacology and Molecular and Cellular biology disciplines) to do a summer project of 10 weeks, directly under her supervision. This scheme provides the selected  student with a stipend reflecting the Scottish National Living Wage.  This program supports early career researchers to develop supervisory and other associated skills.

Fundraising and events at POG:-

Lizzie Malloch, who is a medical student at University of Glasgow, will be running the Edinburgh Half Marathon on 26 May 2019 along with her friends, Heather Morrison, Lucy Ferguson and Sally Kirkpatrick.  This is to raise funds for the Paul O’Gorman Leukaemia Research Centre, a cause very close to her heart as she is the niece of the late Professor Tessa Holyoake, who was the Director and driving force behind the Centre.  Here is the link to the Just Giving page: https://www.justgiving.com/fundraising/lizzie-malloch

Charity Quiz Night, 2nd March at Springfield Cambridge Church Hall, Bishopbriggs
Quiz starts at 7.30pm
BYOB
Tickets £5.00 per person (tea/coffee provided)
Prize for winning team
Suggested maximum team size – 8
Raffle
RSVP: tmd.noon@ntlworld.com

Talks:  Dr Thomas McKerrell, Academic Clinical Lecturer with an interest in Acute Myeloid Leukaemia, University of Cambridge will present his talk at the CRUK Beatson Institute entitled “Age-Related Clonal Haemopoiesis: Clinical Consequences and Potential Mechanisms - A key Role for somatic natural selection” on 4th February 2019 at 12 noon.

George Finney (MRC DTP Student) - Pint of Science 2019 Speakers Wanted!
Pint of Science is a public science festival where researchers explain their latest findings to the public in the comfort of a pub. For the 'Our Body' theme of Pint of Science 2019 we've secured Dram as our venue of choice between May 20th-22nd. The theme for this year is 'Past, Present, and Future' where we are looking for research in any therapeutic development or treatment of disease.

If you have research you want to engage with the public and are interested in giving a talk for this year’s festival, please contact George Finney (g.finney.1@research.gla.ac.uk) for further details!

Staff News 

After 31 years’ continuous service, Professor Rob Mairs retired on Friday 30th November. Prof Mairs has been a leading name in the field of targeted radionuclide therapy, particularly for the treatment of the paediatric tumour, neuroblastoma.

His new occupation will be as a Grandad to his 4 grandchildren, in addition to walking the Scottish Highlands, and playing his well-loved banjo.
Prof Mairs’ remaining post-docs have now amalgamated with Prof Anthony Chalmers’ group on the ground floor of the WWCRC, specialising in Translational Radiation Biology.

‌We are delighted to announce that our colleague Joanne Edwards has recently been promoted to University Professor.

Joanne, who joined the Institute in 2008, is an internationally recognised translational cancer researcher with over 150 publications to her name. She has considerable expertise in developing biomarkers for personalised patient care and has been instrumental in establishing and sharing unique patient tissue cohorts with extensive linked clinical data across a breadth of solid tumours, including colorectal and prostate cancers, which are of particular interest to us in Glasgow. Notably, her work led to her election as a Fellow of the Royal College of Pathologists in 2012, something that is unusual for a non-clinician. Joanne has also supervised numerous PhD students and clinical research fellows, and currently makes an important contribution to teaching more widely as our PGR convenor. She is a fantastic colleague and we are very pleased to be able to congratulate her on this well-deserved promotion.

A warm welcome to our new staff

‌‌I am Alistair Ritchie, and I joined the GPOL team as sequencing laboratory manager in December 2018. After getting a PhD in molecular biology from the University of Nottingham I did some postdoctoral work at the University of Liverpool, then Hospital Universario Marques de Valdecilla in Santander, Spain, and the Centro Nacional de Biotecnologia in Madrid. Following this I led the R&D team at 2B BlackBio S.L. in Madrid, before moving to BioReliance in Glasgow where I was a Responsible Scientist and Study Director for custom GMP and GLP sequencing assays. My previous position was as the Technical Manager in molecular biology at Neogen Europe, leading the team running UKAS accredited food safety and security testing. Tel: 0141 330 2575 Email: Alistair.Ritchie@glasgow.ac.uk

I am Viktor Ahlberg, Administrative Assistant, based between the Laboratory Medicine Building and the Imaging Centre of Excellence. I work closely with Dr Ruth McLaughlin, Dr Karin Oien, Dr Tomoko Iwata, and Clare Orange among many others. Originally from Sweden, I moved to Scotland six years ago to study English and Politics at the University of Glasgow, and then gained an MSc in Human Resource Management from Strathclyde University. My interests are history, geography, and technology, and my career ambition is to join Glasgow University’s HR department one day! Contact: viktor.ahlberg@glasgow.ac.uk

David Walker joined Prof Anthony Chalmers lab as a Research Associate investigating the impact of ATM inhibition on radiation-induced normal brain toxicity. David was recently awarded his PhD by the University of St Andrews where he explored the long-term effects of early-life stress on inflammation, apoptosis and neurogenesis throughout the ageing brain. Email: David.walker.3@glasgow.ac.uk

Nigel Jamieson is a Clinical Senior Lecturer within the Institute of Cancer Sciences and an Honorary HPB surgeon at Glasgow Royal Infirmary. He completed his undergraduate medical degree at the University of Glasgow when his interest in pancreatic cancer research began. He subsequently undertook a PhD funded by the Chief Scientist Office investigating gene expression signatures in pancreatic adenocarcinoma at the Beatson Institute. After completing his surgical training including observership periods at Johns Hopkins, Baltimore and Memorial Sloan Kettering Cancer Centre, New York he undertook an international fellowship year of pancreas and liver surgery in Royal North Shore Hospital, Sydney, Australia where he gained significant experience in post-neoadjuvant therapy pancreatic resections. Grants from the Academy of Sciences and Pancreatic Cancer UK maintained his research output during his surgical training. He was recently awarded a Clinician Scientist Fellowship by Cancer Research UK and upon returning to Glasgow was awarded a Lord Kelvin and Adam Smith Leadership Fellowship from the University of Glasgow.

He has contributed to over 70 peer reviewed publications and with an active role in the development and management of the Precision-Panc platform, his primary research interest now focusses upon the interaction between the genomic landscape, the immune microenvironment and chemotherapy in patients with pancreatic cancer. Specifically, he will look to develop combination therapeutic strategies that target Immune evasion in pancreatic cancer. Email: Nigel.Jamieson@glasgow.ac.uk

Christin Bauer, studied her BSc and MSc in Germany at the Martin-Luther University in Halle (Saale). After her Masters she got a Leonardo da Vinci fellowship to fund a 6 month internship with Dr Marcos Vidal in Glasgow, at the Beatson Institute for Cancer Research. She started her PhD in 2013 in the same lab and defended her Thesis at the start of 2018. She worked on her PhD project till September 2018 then started her new position mid Nov 2018 at the WWCRC with Oliver Maddocks. Email: christin.bauer@glasgow.ac.uk

Samantha Hinsley recently started working as a biostatistician for the CRUK CTU, based in the admin building at Gartnavel. She works as part of the statistics team at the CTU, headed up by Jim Paul. Before this she worked for the Clinical Trials Research Unit at the University of Leeds, where she spent over 6 years working on clinical trials in Oncology, with a keen interest in early phase trials. Email: Samantha.Hinsley@glasgow.ac.uk

Robert Wiesheu studied biology at Ludwig Maximilian University (LMU) in Munich and graduated with a Master's degree in March 2018. He was based at the Beatson Institute in Seth Coffelt’s group in order to perform his master's thesis from September 2017 to March 2018; he then started a PhD position in Munich, which he didn’t enjoy so left. Seth then managed to get him an interview for a Scientific Officer within his group. Robert will be here until the end of September 2019. In the meantime he is trying to find funding/studentships for a PhD project so that he can stay longer and do his PhD with Seth. Email: R.Wiesheu@beatson.gla.ac.uk

Hey, I’m Liam Hayman! I studied biomedical science at University of Abertay, Dundee. Between my third and fourth years, I completed a summer internship in Seth Coffelt’s lab at The Beatson working on the recognition of BRCA1 deficient mammary tumour cells by γδ T cells via the NKG2D receptor. I then completed my honour’s project in Jean-Christophe Bourdon’s lab at University of Dundee, studying the modulation of APR-246 by the isoforms of p53. Prior to commencing my PhD in the Coffelt and Edwards labs, I completed a second summer internship at The Babraham Institute, Cambridge, developing an antibody internalisation assay for screening therapeutic antibodies. I am now working in the Coffelt and Edwards labs, studying the prognostic role of γδ T cells in colorectal cancer. Outside of work, I read, a lot. Email: l.hayman.1@research.gla.ac.uk

Dr Jodie Hay has been appointed to a post-doctoral position on Alison Michie’s recently awarded Bloodwise grant. This grant enables the continuation of our work funded by Bloodwise and MRC, that was recently accepted in Clinical Cancer Research, “E. Cosimo, A. Tarafdar, M.W. Moles, A.K. Holroyd, M.A. Catherwood, N. Malik, J. Hay, K.M. Dunn, A. Macdonald, S.M. Guichard, D. O’Rourke, M.T. Leach, O.J. Sansom, S.C. Cosulich, A.M. McCaig & A.M. Michie (2019). AKT/mTORC2 inhibition activates FOXO1 function in CLL cells reducing B cell receptor-mediated survival.”

Joost Korver, an Erasmus student from the Netherlands will be starting in February working alongside Kristina Kirschner for 6 months.

Awards

At the recent MVLS College Christmas Council on the 20th December 2018, which is a celebration of the Colleges achievements over the past year: A number of our staff members were recognised at an event to which we would like to pass on our congratulations:

New Professorial promotions (2018) - Professor Stephen Tait.

UofG Long Service Awards: (30 years of Service at the University) - Professor Rob Mairs, James Paul and Fiona Conway.

Jim received his award at this event from Professor Dame Anna Dominiczak.

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Another award winner was within MVLS Service Excellence Awards.
(Nominations for these awards are by fellow colleagues in the College nominating a member of staff in the Professional Services staff (Admin, Tech, Ops) or support services that have gone above and beyond to provide excellent service over the year.)

Sandra Deakin won the TRM Service Excellence award and was nominated by seven different people including a number of her PI's that she supports.
Sandra received her award from Dr Carol Clugston.

From January 2019, Sandra will be based 5 days a week in the WWCRC admin office.

The 4 winners of the MVLS Images with impact competition for 2018 were revealed and used as the images for the College 2018 Christmas cards.
Congratulations to everybody who won awards and who received nominations.  Next set of calls for nominations for these awards for 2019 will open later in the year with a closing date in November 2019.

Evangelos Giampazolias has won the 2018 Pontecorvo Prize for best PhD thesis coming from a Cancer Research UK funded student. Evangelos was a student in Stephen Tait's group.

Prof Stephen Tait has been awarded a 3-year project grant from Prostate Cancer UK to investigate immunogenic cell death as a way to better treat advanced prostate cancer.

Dr Seth Coffelt awarded BACR-AstraZeneca Young Scientist Frank Rose Award 2018. Many congratulations to Seth, who has been awarded the BACR-AstraZeneca Young Scientist Frank Rose Award 2018! The purpose of the award is to recognise and reward the achievements of an individual whose work has made significant contributions to translational cancer research. To mark the award, Seth gave a talk at the NCRI conference, which was held in Glasgow earlier this month.

At the November’s ScoRRF meeting: Dr Miranda Ashton and Dr Donna Nile, both members of Prof Anthony Chalmers’ research group, won the prizes for best oral and poster presentations, respectively, whilst attending the Scottish Radiotherapy Research Forum (ScoRRF) which hosted in Stirling, in November 2018.

Natalia Brzozowska  - Natalia was commended for 2 papers in the Life Sciences category at the Global Undergraduate Summit: UofG People and Projects

Daniel Murphy - Has a new grant from the British Lung Foundation, awarded to himself, Seth Coffelt, Kevin Blyth & Clair Rooney (both of QEUH): Pre-clinical in vivo evaluation of immuno-modulatory therapy in MPM

Krishna Yalla - has been selected for the MVLS ISSF Summer Scholarships Scheme 2019. As a part of this program, I get to design a project, interview and select a 3rd year undergraduate student (Genetics, Immunology, Pharmacology and Molecular and Cellular biology disciplines) to do a summer project of 10 weeks, directly under my supervision. This scheme provides the selected student with a stipend reflecting the Scottish National Living Wage.  This program supports early career researchers, such as myself, to develop supervisory and other associated skills.

PhD Student News

Congratulations to all who passed recent Viva’s including:

Ashley Newcombe (Peter Adams; Inhibition of BET and MDM2 is synthetically lethal in AML)

Jiska van der Reest (Eyal Gottlieb; Interplay between Oxidative Stress and Cancer Cell Metabolism)

Dominika Kowalczyk (Danny Huang; Insights into p14ARF inhibition of MDM2 RING domain)

Silvia Halim (Alexei Vazquez; Interplay of cell proliferation and tissue remodelling in colorectal cancer)

Marisa Nacke (David Bryant; The role of ARFGEF IQSEC1 in prostate cancer cell invasion)

Michael Hodder (Owen Sansom; Investigating the role of apoptosis in intestinal homeostasis and dysplasia)

Evdokia Michalopoulou (Jurre Kamphorst; Investigating the role of Macropinocytosis in PTEN loss-driven pancreatic cancer).

Mate Naszai – supervisor Julia Cordero

Sylvia Manero – supervisor Katherine West

Eduardo Gomez-Castaneda – supervisor Heather Jorgenson

Lorna Jackson – supervisor Heather Jorgenson

Jenny Sarrou – supervisor Karen Keeshan

Ahmed Khalaf started his PhD in Vignir Helgason’s group on 3 January 2019. Ahmed was awarded a competitive Newton-Mosharafa PhD Scholarship to support his studies.

Joining Karen Keeshan's lab In November 2018 was Hakem Abilasi (PhD student) and Akbar Shahid (MRes IMB student) joined in January 2019.

Also from Vignir's group - Angela Ianniciello’s abstract to the Keystone Symposia on Autophagy: From Model Systems to Therapeutic Opportunities (Feb 2019, Santa Fe, New Mexico, USA) has been selected for an oral presentation.

Matthew Massett, PhD student Dr Xu Huang's group, attended the American Society of Haematology Annual Meeting in San Diego, California in December 2018

“Last year I presented my research in sunny San Diego at the 2018 American Society of Haematology (ASH) conference. The experience was invigorating! Every talk was meticulous and presented in a logical sequence which made it easier to engage with. The afternoon before the meeting began upcoming researchers like myself attended a training event called ASH-a-Palooza which really captured the excitement and challenges of the field. Overall ASH was an inspiring experience that brought me up-to-date with current research and gave me a great opportunity to network with colleagues from across the world. I will always remember all the researchers and clinicians and their nametags spilling out in droves of every shop, restaurant and hotel in sight. The ASH meeting was the talk of San Diego and deservedly so.”

MSc News

New Name!!! Our Cancer Sciences MSc has changed name to: MSc Cancer Research & Precision Oncology

An exciting development is the revision of the Programme for the 2019 intake; this will reflect the latest changes in cancer treatment and current research in the fast-paced field of cancer. The programme will also have a new name ‘MSc in Cancer Research and Precision Oncology’, to reflect the changes that are being implemented. These changes will be in line with developments in the cancer field, especially the recent developments in Immunotherapy and enable us to take full advantage of expertise within the Beatson CR-UK Drug Discovery Unit, The Beatson West of Scotland Cancer Centre Clinical Trials Unit, Beatson Cancer Research Institute Distinguished Seminar series along with Clinical and Research expertise within ICS and the NHS.

It was another successful year for the MSc Cancer Sciences Programme with all students graduating with excellent results; 7 Distinction, 9 Merit and 7 Pass Grades. The students really enjoyed their time at the University of Glasgow and we joined them to celebrate their achievements at the Winter Graduation. A special thank you to the former Programme Directors Dr Katherine West and Dr Torsten Stein for all their hard work since its launch in 2014 and we wish them every success in their new roles. The new Programme Directors are Dr Helen Wheadon and Prof Joanne Edwards.

Graduation photos

We welcomed a new cohort of students in September 2018 from afar a field as; Greece, Spain, Turkey, Hong Kong, The Philippines, Iraq, Oman, Thailand, India, Malaysia, China, Algeria, Canada, Saudi Arabia as well as students from the UK.  We hope they have all settling in to Scottish life and are enjoying their studies so far.

One of our new students Aslihan Bastem is from Turkey, where she did her Bachelor in Molecular Biology and Genetics, followed by an MSc in Genetics before applying for the MSc Cancer Sciences here.  This is what Aslihan had to say about her experience so far…
‘Every day we learn different things, because learning is endless. And in this programme, the most important one is how to approach to studies and interpret them in addition to propose novel and future approaches’.
Aslihan would like to pursue a PhD degree in the UK, on completing her MSc.

Publications and publicity

The Global Undergraduate Summit in Dublin, Ireland:

Attending from the University of Glasgow was Natalia Brzozowska who was commended in the Life Sciences category for her papers “Dysregulation of microRNAs miR-986, miR-281-1 and miR-281-2 affects Malpighian tubule function and morphology in Drosophila melanogaster” and “Is circular RNA CDR1as a stabilizing reservoir for miRNA rather than an inhibitory sponge?”

Angela Ianniciello’s abstract to the Keystone Symposia on Autophagy: "From Model Systems to Therapeutic Opportunities" (Feb 2019, Santa Fe, New Mexico, USA) has been selected for an oral presentation. Angela is a member of Vignir Helgason's group

Results of a study on mannose, led by Prof Kevin Ryan, were published in Nature and received a lot of media attention. BBC coverage: "Simple sugar supplement 'can slow cancer growth" and "Sugary supplement mannose could help fight cancer" Press release from CRUK


Published paper Nature Communications:
Shahzya Chaudhury, Caitríona O'Connor, Ana Elodia Canete Sanchez, Joana Silvestre, Evgenia Sarrou, Jarny Choi, Áine Prendergast, Pamela Johnston, Christine Wells, Brenda Gibson, and Karen Keeshan.
"Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias". Nat Commun. 2018 Dec 11;9(1):5280. doi: 10.1038/s41467-018-07584-1. PMID: 30538250. IF 12.3.

Press coverage: UofG News

The Sun, The Herald, The Times, The National

Open Access Update

Dr Mary Donaldson, Research Information Management Service, will be at the WWCRC once a fortnight for a trial period of six sessions. If there is sufficient demand, this service will be extended beyond the trial period. She will be able to give advice on the following topics:

• General information and support on Open Access
• Open Access for REF
• Research Data Management
• Reporting your research outcomes to funders

Mary can be found in the write-up area on level 3, every second Monday (from Monday 14 January) from 9am - 2pm.

If you have any queries please contact the Open Access Team at: research-openaccess@glasgow.ac.uk or research-datamanagement@glasgow.ac.uk

Events update

We were delighted by the turn out of staff and students at the ICS Social Committee Halloween party held at the Garscube Tennis Club on 31 October. Lots of pizza was consumed whilst sharing some terrible jokes together!

A big thank you to the staff and students who attended the coffee morning in aid of International Men’s Day in November, raising almost £50 supporting Movember and Prostate Cancer.

Our Festive events were a great success, with everyone coming together to help decorate the Christmas tree in the café area where some beautiful and inspiring Festive Wishes were written on tags in different languages. Congratulations to team “Cotton Headed Ninny Muggins” for winning the Ecksmas Quiz hosted by Wee Eck. We all had a hoot!

Thanks to all who donated to our Food Bank collections. All donated items went to Drumchapel Food Bank.

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Things to come in 2019….

Pucker up for our Valentine’s Day event on 14 February, 3pm. Join us for cake and coffee in the WWCRC café area.

International Women’s Day coffee morning on 8 March, 10am, WWCRC café area.

Summer event – details to follow.

The Social Committee is dedicated in providing fun opportunities for ICS staff and students to come together and get to know each other better. It’s important for a workplace to have an element of fun, time to down tools and talk to the people with whom you spend most of your week with, about something other than work!
If you are interested in joining the ICS Social Committee please contact: cancersci-ins-social@glasgow.ac.uk

Current ICS Social Committee members are: Angela Campbell (Admin/Chairperson); Jo Thomson (Admin); Maureen Watt (Admin); Kathryn Pennel (PhD Student); Quarat Al-Wahid (PGR Student); Sharon Burns (Technical); Eric Kalkman (Technical); Shaun Patterson (PhD Student - POG); Liam Hayman (PhD Student); Iain Turner (Central Services)

Housekeeping Reminders

Please be aware that staff members who host meetings in WWCRC meeting rooms are directly responsible for the disposal of waste and switching off lights and AV equipment after use. New bulbs for projectors cost around £250 each.

Hospitality have asked us to remind staff to clean up after any function. Often food waste has been left overnight as well as over weekend to rot and is not picked up until the next meeting, making it unpleasant for those who have just come in to the room. It doesn’t need to be said that this is poor hygiene practice and against Health and safety standards. Black bin bags are always provided, so please use them to dispose of waste and leave the room as you would expect it to be found.

For the keen cyclists among us…

Please visit the web pages for anything you need to know regarding cycling.

UofG Cycling

A reminder also that Dr Bike has monthly scheduled visits around the various University campus sites. Take your bicycle along to the bicycle shelter outside the Mary Stewart Building for some bike mechanic magic.

Future Dr Bike dates can be found here:

Dr Bike dates

Or follow UofG Bicycle User Group on Facebook: UofG Bicycle User Group

Your NERD Committee

We are NERD! A collaborative network aiming to:
 
•    Provide career support, information and advice for Early Career Researchers in IIIs and ICAMS
•    Foster collegiality, collaboration and sharing of resources within and between IIIs and ICAMS
•    Better understand the challenges facing ECRs in IIIs/ICAMS, advocating for their needs to senior management
 
Website - NERD
Twitter - @iiiiNERD
Email - cams-iii-nerd@glasgow.ac.uk