Dr Helen Wheadon

  • Non-Clinical Senior Lecturer Cancer Biologist (Paul O'Gorman Leukaemia Research Centre)

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Exploring gene expression in individual CML stem cells to predict response to therapy in newly diagnosed patients
    Tenovus Scotland
    2016 - 2017
     
  • Single cell RNA sequencing on primative human leukaemic stem cell population to identify novel biomarkers involved in drug resistance and future immunotherapy
    Wellcome Trust
    2016 - 2018
     
  • Chronic Myeloid Leukaemia tyrosine kinase inhibitor response classification by quantitative RT-PCR
    NHS Greater Glasgow and Clyde
    2015 - 2016
     
  • Validating induced pluripotent stem cells (iPSC) as an acceptable model for pre-clinical drug screening in haematological malignancies
    Animal Free Research UK
    2014 - 2017
     
  • Investigation of JAK2 targets is myeloproliferative disorders
    Chief Scientist Office
    2013 - 2016
     
  • Wellcome Trust Scottish Translational Medicine and Therapeutics Initiative studentship
    Wellcome Trust
    2012 - 2016
     
  • Human embryonic stem cells as a model for understanding transcriptional regulation of Myeloproliferative neoplasms
    Bloodwise
    2011 - 2013
     

Publications

List by: Type | Date

Jump to: 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2011 | 2010 | 2009 | 2008 | 2004 | 2003 | 2002
Number of items: 27.

2018

Toofan, P., Busch, C., Morrison, H., O'Brien, S., Jørgensen, H., Copland, M. and Wheadon, H. (2018) Chronic myeloid leukemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal. Cell Death and Disease, 9, 927. (doi:10.1038/s41419-018-0905-2) (PMID:30206237) (PMCID:PMC6134087)

2017

Biggs, M. J.P. et al. (2017) The functional response of mesenchymal stem cells to electron-beam patterned elastomeric surfaces presenting micrometer to nanoscale heterogeneous rigidity. Advanced Materials, 29(39), 1702119. (doi:10.1002/adma.201702119) (PMID:28861921)

Lewis, N. S., Lewis, E. E.L., Mullin, M., Wheadon, H. , Dalby, M. J. and Berry, C. C. (2017) Magnetically levitated mesenchymal stem cell spheroids cultured with a collagen gel maintain phenotype and quiescence. Journal of Tissue Engineering, 8, pp. 1-11. (doi:10.1177/2041731417704428) (PMID:28616152) (PMCID:PMC5460809)

2016

Horne, G. A. , Morrison, H., Campbell, V., Kinstrie, R. , Cassels, J., Hair, A., Vetrie, D. , Wheadon, H. , Holyoake, T. L. and Copland, M. (2016) Notch Pathway Activation Targets Leukemic Stem Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML). American Society of Hematology 58th Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.

Chaudhury, S. S. , Wheadon, H. , Gibson, B. and Keeshan, K. (2016) The Bone Marrow Niche Distinguishes Young and Old Leukemia. 58th ASH Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.

Toofan, P. and Wheadon, H. (2016) Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis. Biochemical Society Transactions, 44(5), pp. 1455-1463. (doi:10.1042/BST20160104) (PMID:27911727)

Lewis, E. E. L., Wheadon, H. , Lewis, N., Yang, J., Mullin, M., Hursthouse, A., Stirling, D., Dalby, M. J. and Berry, C. C. (2016) A quiescent, regeneration-responsive tissue engineered mesenchymal stem cell bone marrow niche model via magnetic levitation. ACS Nano, 10(9), pp. 8346-8354. (doi:10.1021/acsnano.6b02841) (PMID:27602872)

Middleton, O., Wheadon, H. and Michie, A. (2016) Classical complement pathway. In: Ratcliffe, M.J.H. (ed.) Encyclopedia of Immunobiology, 1st Edition. Elsevier: New York, NY. ISBN 9780123742797

Irvine, D. A. et al. (2016) Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Scientific Reports, 6, 25476. (doi:10.1038/srep25476) (PMID:27157927) (PMCID:PMC4860619)

2015

Ford, C. A. et al. (2015) Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma. Current Biology, 25(5), pp. 577-588. (doi:10.1016/j.cub.2014.12.059) (PMID:25702581) (PMCID:PMC4353688)

Kranc, K. R. et al. (2015) Acute loss of Cited2 impairs Nanog expression and decreases self-renewal of mouse embryonic stem cells. Stem Cells, 33(3), pp. 699-712. (doi:10.1002/stem.1889) (PMID:25377420)

Middleton, O., Cosimo, E., Dobbin, E., McCaig, A.M., Clarke, C., Brant, A.M., Leach, M.T., Michie, A.M. and Wheadon, H. (2015) Complement deficiencies limit CD20 monoclonal antibody treatment efficacy in CLL. Leukemia, 29(1), pp. 107-114. (doi:10.1038/leu.2014.146) (PMID:24787488)

2014

Gallipoli, P., Cook, A., Rhodes, S. , Hopcroft, L. , Wheadon, H. , Whetton, A. D., Jorgensen, H. G., Bhatia, R. and Holyoake, T. L. (2014) JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of chronic phase CML CD34+ cells in vitro and in vivo. Blood, 124(9), pp. 1492-1501. (doi:10.1182/blood-2013-12-545640) (PMID:24957147) (PMCID:PMC4148771)

Toofan, P., Irvine, D., Hopcroft, L. , Copland, M. and Wheadon, H. (2014) The role of the bone morphogenetic proteins in leukaemic stem cell persistence. Biochemical Society Transactions, 42(4), pp. 809-815. (doi:10.1042/BST20140037)

2013

Cosimo, E. et al. (2013) Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells. Clinical Cancer Research, 19(9), pp. 2393-2405. (doi:10.1158/1078-0432.CCR-12-2170)

Rhodes, S. , Copland, M. , Hopcroft, L. , Sayeski, P. and Wheadon, H. (2013) Identification of JAK2 dependent transcriptional regulators in CML. In: 42nd Annual Scientific Meeting of the ISEH – Society for Hematology and Stem Cells, Vienna, Austria, 22-25 Aug 2013, S47-S47.

Sands, W.A., Copland, M. and Wheadon, H. (2013) Targeting self-renewal pathways in myeloid malignancies. Cell Communication and Signaling, 11(33), (doi:10.1186/1478-811X-11-33)

Tarafdar, A., Dobbin, E., Corrigan, P., Freeburn, R. and Wheadon, H. (2013) Canonical Wnt signaling promotes early hematopoietic progenitor formation and erythroid specification during embryonic stem cell differentiation. PLoS ONE, 8(11), e81030. (doi:10.1371/journal.pone.0081030) (PMID:24324557) (PMCID:PMC3850021)

2011

Wheadon, H. , Ramsey, J.M., Dobbin, E., Dickson, G.J., Corrigan, P.M., Freeburn, R.W. and Thompson, A. (2011) Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis. Stem Cells and Development, 20(8), pp. 1465-1476. (doi:10.1089/scd.2010.0226)

2010

Dobbin, E., Graham, C., Freeburn, R.W., Unwin, R.D., Griffiths, J.R., Pierce, A., Whetton, A.D. and Wheadon, H. (2010) Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways. Stem Cell Research, 5(3), pp. 226-243. (doi:10.1016/j.scr.2010.08.001)

2009

Dobbin, E., Graham, C., Corrigan, P., Thomas, K., Freeburn, R. and Wheadon, H. (2009) Tel/PDGFRβ induces stem cell differentiation via the Ras/ERK and STAT5 signaling pathways. Experimental Hematology, 37(1), pp. 111-121. (doi:10.1016/j.exphem.2008.09.012)

Corrigan, P.M., Dobbin, E., Freeburn, R.W. and Wheadon, H. (2009) Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis. Stem Cells and Development, 18(5), pp. 759-771. (doi:10.1089/scd.2008.0270)

2008

Dobbin, E., Corrigan, P.M., Walsh, C.P., Welham, M.J., Freeburn, R.W. and Wheadon, H. (2008) Tel/PDGFRβ inhibits self-renewal and directs myelomonocytic differentiation of ES cells. Leukemia Research, 32(10), pp. 1554-1564. (doi:10.1016/j.leukres.2008.02.007)

2004

Paling, N.R.D., Wheadon, H. , Bone, H.K. and Welham, M.J. (2004) Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. Journal of Biological Chemistry, 279(46), pp. 48063-48070. (doi:10.1074/jbc.M406467200)

2003

Wheadon, H. , Edmead, C. and Welham, M.J. (2003) Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2). Biochemical Journal, 376(1), pp. 147-157. (doi:10.1042/BJ20031160)

Wheadon, H. and Welham, M.J. (2003) The coupling of TEL/PDGF R to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases. Blood, 102(4), pp. 1480-1489. (doi:10.1182/blood-2002-09-2974)

2002

Wheadon, H. , Paling, N.R.D. and Welham, M.J. (2002) Molecular interactions of SHP1 and SHP2 in IL-3-signalling. Cellular Signalling, 14(3), pp. 219-229. (doi:10.1016/S0898-6568(01)00241-8)

This list was generated on Sun Dec 16 17:21:31 2018 GMT.
Number of items: 27.

Articles

Toofan, P., Busch, C., Morrison, H., O'Brien, S., Jørgensen, H., Copland, M. and Wheadon, H. (2018) Chronic myeloid leukemia cells require the bone morphogenic protein pathway for cell cycle progression and self-renewal. Cell Death and Disease, 9, 927. (doi:10.1038/s41419-018-0905-2) (PMID:30206237) (PMCID:PMC6134087)

Biggs, M. J.P. et al. (2017) The functional response of mesenchymal stem cells to electron-beam patterned elastomeric surfaces presenting micrometer to nanoscale heterogeneous rigidity. Advanced Materials, 29(39), 1702119. (doi:10.1002/adma.201702119) (PMID:28861921)

Lewis, N. S., Lewis, E. E.L., Mullin, M., Wheadon, H. , Dalby, M. J. and Berry, C. C. (2017) Magnetically levitated mesenchymal stem cell spheroids cultured with a collagen gel maintain phenotype and quiescence. Journal of Tissue Engineering, 8, pp. 1-11. (doi:10.1177/2041731417704428) (PMID:28616152) (PMCID:PMC5460809)

Toofan, P. and Wheadon, H. (2016) Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis. Biochemical Society Transactions, 44(5), pp. 1455-1463. (doi:10.1042/BST20160104) (PMID:27911727)

Lewis, E. E. L., Wheadon, H. , Lewis, N., Yang, J., Mullin, M., Hursthouse, A., Stirling, D., Dalby, M. J. and Berry, C. C. (2016) A quiescent, regeneration-responsive tissue engineered mesenchymal stem cell bone marrow niche model via magnetic levitation. ACS Nano, 10(9), pp. 8346-8354. (doi:10.1021/acsnano.6b02841) (PMID:27602872)

Irvine, D. A. et al. (2016) Deregulated hedgehog pathway signaling is inhibited by the smoothened antagonist LDE225 (Sonidegib) in chronic phase chronic myeloid leukaemia. Scientific Reports, 6, 25476. (doi:10.1038/srep25476) (PMID:27157927) (PMCID:PMC4860619)

Ford, C. A. et al. (2015) Oncogenic properties of apoptotic tumor cells in aggressive B cell lymphoma. Current Biology, 25(5), pp. 577-588. (doi:10.1016/j.cub.2014.12.059) (PMID:25702581) (PMCID:PMC4353688)

Kranc, K. R. et al. (2015) Acute loss of Cited2 impairs Nanog expression and decreases self-renewal of mouse embryonic stem cells. Stem Cells, 33(3), pp. 699-712. (doi:10.1002/stem.1889) (PMID:25377420)

Middleton, O., Cosimo, E., Dobbin, E., McCaig, A.M., Clarke, C., Brant, A.M., Leach, M.T., Michie, A.M. and Wheadon, H. (2015) Complement deficiencies limit CD20 monoclonal antibody treatment efficacy in CLL. Leukemia, 29(1), pp. 107-114. (doi:10.1038/leu.2014.146) (PMID:24787488)

Gallipoli, P., Cook, A., Rhodes, S. , Hopcroft, L. , Wheadon, H. , Whetton, A. D., Jorgensen, H. G., Bhatia, R. and Holyoake, T. L. (2014) JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of chronic phase CML CD34+ cells in vitro and in vivo. Blood, 124(9), pp. 1492-1501. (doi:10.1182/blood-2013-12-545640) (PMID:24957147) (PMCID:PMC4148771)

Toofan, P., Irvine, D., Hopcroft, L. , Copland, M. and Wheadon, H. (2014) The role of the bone morphogenetic proteins in leukaemic stem cell persistence. Biochemical Society Transactions, 42(4), pp. 809-815. (doi:10.1042/BST20140037)

Cosimo, E. et al. (2013) Inhibition of NF-κB-mediated signaling by the cyclin-dependent kinase inhibitor CR8 overcomes pro-survival stimuli to induce apoptosis in chronic lymphocytic leukemia cells. Clinical Cancer Research, 19(9), pp. 2393-2405. (doi:10.1158/1078-0432.CCR-12-2170)

Sands, W.A., Copland, M. and Wheadon, H. (2013) Targeting self-renewal pathways in myeloid malignancies. Cell Communication and Signaling, 11(33), (doi:10.1186/1478-811X-11-33)

Tarafdar, A., Dobbin, E., Corrigan, P., Freeburn, R. and Wheadon, H. (2013) Canonical Wnt signaling promotes early hematopoietic progenitor formation and erythroid specification during embryonic stem cell differentiation. PLoS ONE, 8(11), e81030. (doi:10.1371/journal.pone.0081030) (PMID:24324557) (PMCID:PMC3850021)

Wheadon, H. , Ramsey, J.M., Dobbin, E., Dickson, G.J., Corrigan, P.M., Freeburn, R.W. and Thompson, A. (2011) Differential Hox expression in murine embryonic stem cell models of normal and malignant hematopoiesis. Stem Cells and Development, 20(8), pp. 1465-1476. (doi:10.1089/scd.2010.0226)

Dobbin, E., Graham, C., Freeburn, R.W., Unwin, R.D., Griffiths, J.R., Pierce, A., Whetton, A.D. and Wheadon, H. (2010) Proteomic analysis reveals a novel mechanism induced by the leukemic oncogene Tel/PDGFRβ in stem cells: activation of the interferon response pathways. Stem Cell Research, 5(3), pp. 226-243. (doi:10.1016/j.scr.2010.08.001)

Dobbin, E., Graham, C., Corrigan, P., Thomas, K., Freeburn, R. and Wheadon, H. (2009) Tel/PDGFRβ induces stem cell differentiation via the Ras/ERK and STAT5 signaling pathways. Experimental Hematology, 37(1), pp. 111-121. (doi:10.1016/j.exphem.2008.09.012)

Corrigan, P.M., Dobbin, E., Freeburn, R.W. and Wheadon, H. (2009) Patterns of Wnt/Fzd/LRP gene expression during embryonic hematopoiesis. Stem Cells and Development, 18(5), pp. 759-771. (doi:10.1089/scd.2008.0270)

Dobbin, E., Corrigan, P.M., Walsh, C.P., Welham, M.J., Freeburn, R.W. and Wheadon, H. (2008) Tel/PDGFRβ inhibits self-renewal and directs myelomonocytic differentiation of ES cells. Leukemia Research, 32(10), pp. 1554-1564. (doi:10.1016/j.leukres.2008.02.007)

Paling, N.R.D., Wheadon, H. , Bone, H.K. and Welham, M.J. (2004) Regulation of embryonic stem cell self-renewal by phosphoinositide 3-kinase-dependent signaling. Journal of Biological Chemistry, 279(46), pp. 48063-48070. (doi:10.1074/jbc.M406467200)

Wheadon, H. , Edmead, C. and Welham, M.J. (2003) Regulation of interleukin-3-induced substrate phosphorylation and cell survival by SHP-2 (Src-homology protein tyrosine phosphatase 2). Biochemical Journal, 376(1), pp. 147-157. (doi:10.1042/BJ20031160)

Wheadon, H. and Welham, M.J. (2003) The coupling of TEL/PDGF R to distinct functional responses is modulated by the presence of cytokine: involvement of mitogen-activated protein kinases. Blood, 102(4), pp. 1480-1489. (doi:10.1182/blood-2002-09-2974)

Wheadon, H. , Paling, N.R.D. and Welham, M.J. (2002) Molecular interactions of SHP1 and SHP2 in IL-3-signalling. Cellular Signalling, 14(3), pp. 219-229. (doi:10.1016/S0898-6568(01)00241-8)

Book Sections

Middleton, O., Wheadon, H. and Michie, A. (2016) Classical complement pathway. In: Ratcliffe, M.J.H. (ed.) Encyclopedia of Immunobiology, 1st Edition. Elsevier: New York, NY. ISBN 9780123742797

Conference or Workshop Item

Horne, G. A. , Morrison, H., Campbell, V., Kinstrie, R. , Cassels, J., Hair, A., Vetrie, D. , Wheadon, H. , Holyoake, T. L. and Copland, M. (2016) Notch Pathway Activation Targets Leukemic Stem Cells in Chronic-Phase Chronic Myeloid Leukemia (CP-CML). American Society of Hematology 58th Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.

Chaudhury, S. S. , Wheadon, H. , Gibson, B. and Keeshan, K. (2016) The Bone Marrow Niche Distinguishes Young and Old Leukemia. 58th ASH Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.

Conference Proceedings

Rhodes, S. , Copland, M. , Hopcroft, L. , Sayeski, P. and Wheadon, H. (2013) Identification of JAK2 dependent transcriptional regulators in CML. In: 42nd Annual Scientific Meeting of the ISEH – Society for Hematology and Stem Cells, Vienna, Austria, 22-25 Aug 2013, S47-S47.

This list was generated on Sun Dec 16 17:21:31 2018 GMT.