Dr Kristina Kirschner

  • Research Associate (Epigenetics)

Biography

Kristina received her PhD from the University of Edinburgh characterising one of the first premature ageing mouse models. Her interest in ageing and cancer continued throughout her postdoc at the CRUK Cambridge Institute and at the Department of Haematology at the University of Cambridge, where she worked on the functional genomics of p53 in senescence and on haematopoiesis in ageing using single cell approaches. Kristina recently moved to the Institute of Cancer Sciences at the University of Glasgow, continuing her work in cancer heterogeneity and age- dependence of tumorigenesis as a junior group leader. Kristina also runs the single cell genomics core facility for the Institute for Cancer Sciences.

Wellcome Trust ISSF Fellowship 2016-2018

EHA-ASH TRTH Training Fellowship 2018


Research interests

Kristina is interested in the interplay between ageing and cancer, using a variety of model systems.

Current projects are:

- Elucidating heterogeneity in the ageing haematopoietic stem cell compartment

- Exploring secondary senescence pathways in vitro and in vivo

- Defining mutational and epigenetic changes in patients with Myeloproliferative Disease


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Elucidating metabolomics changes in myeloproliferative neoplasms
    Tenovus Scotland
    2019 - 2020
     
  • Defining Epigenetic age as a novel tool for cancer grading
    NHS Greater Glasgow and Clyde
    2019 - 2019
     
  • ERADICATION OF THE LEUKAEMIC CLONE IN MYELOPROLIFERATIVE NEOPLASMS
    University of Manchester
    2018 - 2019
     
  • Support for Epigenetics research
    Medical Research Council
    2017 - 2017
     
  • Fellowship Award:Elucidating the response of the aged transcriptome and genome to oncogenic stress in haematopoietic stem cells using single cell approaches
    Wellcome Trust
    2016 - 2018
     

Supervision

    I currently supervise one Ph.D. student as primary supervisor entitled "Heterogeneity within the ageing human haemopoietic compartment and predisposition to cancer". This project is funded by the MRC DTP programme in collaboration with Prof. Mhairi Copland (UoG) and Dr. Tamir Chandra at the University if Edinburgh.

Teaching

Kristina currently teaches on the Master for Cancer Sciences programme and is involved with Master of Research student training.


Research datasets

Jump to: 2019 | 2017 | 2016 | 2015
Number of items: 5.

2019

Chandra, T., Rattanavirotkul, N. and Kirschner, K. (2019) Notch signalling mediates secondary senescence- imaging data. [Data Collection]

2017

Kirschner, K. and Green, A. (2017) Single Cell RNA-Sequencing using smart-seq2 of young and old murine hematopoietic stem cells. [Data Collection]

Kirschner, K. and Green, A. (2017) Gene expression profiling upon TPO treatment. [Data Collection]

2016

Green, A. and Kirschner, K. (2016) SC3-consensus clustering of single cell RNA-Seq data. [Data Collection]

2015

Kirschner, K. , Samarajiwa, S., Menon, S. and , (2015) Phenotype specific analyses of p53 reveal distinct regulatory mechanism for chronically activated p53. [Data Collection]

This list was generated on Tue Jun 25 00:33:31 2019 BST.

Publications

List by: Type | Date

Jump to: 2019 | 2018 | 2017 | 2016 | 2015 | 2013 | 2012 | 2010 | 2009 | 2007 | 2003
Number of items: 16.

2019

Teo, Y. V. et al. (2019) Notch signalling mediates secondary senescence. Cell Reports, (Accepted for Publication)

2018

Baran-Gale, J., Chandra, T. and Kirschner, K. (2018) Experimental design for single-cell RNA sequencing. Briefings in Functional Genomics, 17(4), pp. 233-239. (doi:10.1093/bfgp/elx035) (PMID:29126257) (PMCID:PMC6063265)

Kirschner, K. , Krueger, F., Green, A. R. and Chandra, T. (2018) Multiplexing for oxidative bisulfite sequencing (oxBS-seq). In: Tost, J. (ed.) DNA Methylation Protocols. Series: Methods in molecular biology, 1708 (1708). Humana Press: New York, pp. 665-678. ISBN 9781493974795 (doi:10.1007/978-1-4939-7481-8_34)

2017

Kirschner, K. et al. (2017) Proliferation drives aging-related functional decline in a subpopulation of the hematopoietic stem cell compartment. Cell Reports, 19(8), pp. 1503-1511. (doi:10.1016/j.celrep.2017.04.074) (PMID:28538171) (PMCID:PMC5457484)

Kiselev, V. Y. et al. (2017) SC3: consensus clustering of single cell RNA-seq data. Nature Methods, 14(5), pp. 483-486. (doi:10.1038/nmeth.4236) (PMID:28346451)

2016

Chandra, T. and Kirschner, K. (2016) Chromosome organisation during ageing and senescence. Current Opinion in Cell Biology, 40, pp. 161-167. (doi:10.1016/j.ceb.2016.03.020) (PMID:27101466)

Park, H. J., Li, J., Hannah, R., Biddie, S., Leal‐Cervantes, A. I., Kirschner, K. , Flores Santa Cruz, D., Sexl, V., Göttgens, B. and Green, A. R. (2016) Cytokine‐induced megakaryocytic differentiation is regulated by genome‐wide loss of a uSTAT transcriptional program. EMBO Journal, 35(6), pp. 580-594. (doi:10.15252/embj.201592383) (PMID:26702099) (PMCID:PMC4801948)

2015

Kirschner, K. et al. (2015) Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53. PLoS Genetics, 11(3), e1005053. (doi:10.1371/journal.pgen.1005053) (PMID:25790137) (PMCID:PMC4366240)

Chandra, T., Ewels, P. A., Schoenfelder, S., Furlan-Magaril, M., Wingett, S. W., Kirschner, K. , Thuret, J.-Y., Andrews, S., Fraser, P. and Reik, W. (2015) Global reorganization of the nuclear landscape in senescent cells. Cell Reports, 10(4), pp. 471-483. (doi:10.1016/j.celrep.2014.12.055) (PMID:25640177) (PMCID:PMC4542308)

2013

Kent, D. G. et al. (2013) Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion. PLoS Biology, 11(6), e1001576. (doi:10.1371/journal.pbio.1001576) (PMID:23750118) (PMCID:PMC3672217)

Ward, M. C. et al. (2013) Latent regulatory potential of human-specific repetitive elements. Molecular Cell, 49(2), pp. 262-272. (doi:10.1016/j.molcel.2012.11.013) (PMID:23246434) (PMCID:PMC3560060)

2012

Chandra, T. et al. (2012) Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Molecular Cell, 47(2), pp. 203-214. (doi:10.1016/j.molcel.2012.06.010) (PMID:22795131) (PMCID:PMC3701408)

2010

Kirschner, K. and Melton, D. W. (2010) Multiple roles of the ERCC1-XPF endonuclease in DNA repair and resistance to anticancer drugs. Anticancer Research, 30(9), pp. 3223-3232. (PMID:20944091)

2009

Young, A. R.J. et al. (2009) Autophagy mediates the mitotic senescence transition. Genes and Development, 23(7), pp. 798-803. (doi:10.1101/gad.519709) (PMID:19279323) (PMCID:PMC2666340)

2007

Kirschner, K. , Singh, R., Prost, S. and Melton, D. W. (2007) Characterisation of Ercc1 deficiency in the liver and in conditional Ercc1-deficient primary hepatocytes in vitro. DNA Repair, 6(3), pp. 304-316. (doi:10.1016/j.dnarep.2006.10.020) (PMID:17126084)

2003

Gunnarsson, C., Ahnström, M., Kirschner, K. , Olsson, B., Nordenskjöld, B., Rutqvist, L. E., Skoog, L. and Stål, O. (2003) Amplification of HSD17B1 and ERBB2 in primary breast cancer. Oncogene, 22(1), pp. 34-40. (doi:10.1038/sj.onc.1206078) (PMID:12527905)

This list was generated on Mon Jun 24 06:57:52 2019 BST.
Number of items: 16.

Articles

Teo, Y. V. et al. (2019) Notch signalling mediates secondary senescence. Cell Reports, (Accepted for Publication)

Baran-Gale, J., Chandra, T. and Kirschner, K. (2018) Experimental design for single-cell RNA sequencing. Briefings in Functional Genomics, 17(4), pp. 233-239. (doi:10.1093/bfgp/elx035) (PMID:29126257) (PMCID:PMC6063265)

Kirschner, K. et al. (2017) Proliferation drives aging-related functional decline in a subpopulation of the hematopoietic stem cell compartment. Cell Reports, 19(8), pp. 1503-1511. (doi:10.1016/j.celrep.2017.04.074) (PMID:28538171) (PMCID:PMC5457484)

Kiselev, V. Y. et al. (2017) SC3: consensus clustering of single cell RNA-seq data. Nature Methods, 14(5), pp. 483-486. (doi:10.1038/nmeth.4236) (PMID:28346451)

Chandra, T. and Kirschner, K. (2016) Chromosome organisation during ageing and senescence. Current Opinion in Cell Biology, 40, pp. 161-167. (doi:10.1016/j.ceb.2016.03.020) (PMID:27101466)

Park, H. J., Li, J., Hannah, R., Biddie, S., Leal‐Cervantes, A. I., Kirschner, K. , Flores Santa Cruz, D., Sexl, V., Göttgens, B. and Green, A. R. (2016) Cytokine‐induced megakaryocytic differentiation is regulated by genome‐wide loss of a uSTAT transcriptional program. EMBO Journal, 35(6), pp. 580-594. (doi:10.15252/embj.201592383) (PMID:26702099) (PMCID:PMC4801948)

Kirschner, K. et al. (2015) Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53. PLoS Genetics, 11(3), e1005053. (doi:10.1371/journal.pgen.1005053) (PMID:25790137) (PMCID:PMC4366240)

Chandra, T., Ewels, P. A., Schoenfelder, S., Furlan-Magaril, M., Wingett, S. W., Kirschner, K. , Thuret, J.-Y., Andrews, S., Fraser, P. and Reik, W. (2015) Global reorganization of the nuclear landscape in senescent cells. Cell Reports, 10(4), pp. 471-483. (doi:10.1016/j.celrep.2014.12.055) (PMID:25640177) (PMCID:PMC4542308)

Kent, D. G. et al. (2013) Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion. PLoS Biology, 11(6), e1001576. (doi:10.1371/journal.pbio.1001576) (PMID:23750118) (PMCID:PMC3672217)

Ward, M. C. et al. (2013) Latent regulatory potential of human-specific repetitive elements. Molecular Cell, 49(2), pp. 262-272. (doi:10.1016/j.molcel.2012.11.013) (PMID:23246434) (PMCID:PMC3560060)

Chandra, T. et al. (2012) Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Molecular Cell, 47(2), pp. 203-214. (doi:10.1016/j.molcel.2012.06.010) (PMID:22795131) (PMCID:PMC3701408)

Kirschner, K. and Melton, D. W. (2010) Multiple roles of the ERCC1-XPF endonuclease in DNA repair and resistance to anticancer drugs. Anticancer Research, 30(9), pp. 3223-3232. (PMID:20944091)

Young, A. R.J. et al. (2009) Autophagy mediates the mitotic senescence transition. Genes and Development, 23(7), pp. 798-803. (doi:10.1101/gad.519709) (PMID:19279323) (PMCID:PMC2666340)

Kirschner, K. , Singh, R., Prost, S. and Melton, D. W. (2007) Characterisation of Ercc1 deficiency in the liver and in conditional Ercc1-deficient primary hepatocytes in vitro. DNA Repair, 6(3), pp. 304-316. (doi:10.1016/j.dnarep.2006.10.020) (PMID:17126084)

Gunnarsson, C., Ahnström, M., Kirschner, K. , Olsson, B., Nordenskjöld, B., Rutqvist, L. E., Skoog, L. and Stål, O. (2003) Amplification of HSD17B1 and ERBB2 in primary breast cancer. Oncogene, 22(1), pp. 34-40. (doi:10.1038/sj.onc.1206078) (PMID:12527905)

Book Sections

Kirschner, K. , Krueger, F., Green, A. R. and Chandra, T. (2018) Multiplexing for oxidative bisulfite sequencing (oxBS-seq). In: Tost, J. (ed.) DNA Methylation Protocols. Series: Methods in molecular biology, 1708 (1708). Humana Press: New York, pp. 665-678. ISBN 9781493974795 (doi:10.1007/978-1-4939-7481-8_34)

This list was generated on Mon Jun 24 06:57:52 2019 BST.