Dr Kristina Kirschner

  • Research Associate (Epigenetics)

Biography

Kristina received her PhD from the University of Edinburgh characterising one of the first premature ageing mouse models. Her interest in ageing and cancer continued throughout her postdoc at the CRUK Cambridge Institute and at the Department of Haematology at the University of Cambridge, where she worked on the functional genomics of p53 in senescence and on haematopoiesis in ageing using single cell approaches. Kristina recently moved to the Institute of Cancer Sciences at the University of Glasgow, continuing her work in cancer heterogeneity and age- dependence of tumorigenesis.

Wellcome Trust ISSF Fellowship 2016-2018

EHA-ASH TRTH Training Fellowship 2018


Research interests

Kristina is interested in the interplay between ageing and cancer, using a variety of model systems.

Current projects are:

- Elucidating heterogeneity in the ageing haematopoietic stem cell compartment

- Exploring secondary senescence pathways in vitro and in vivo

- Defining mutational and epigenetic changes in patients with Myeloproliferative Disease


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Support for Epigenetics research
    Medical Research Council
    2017 - 2017
     
  • Fellowship Award:Elucidating the response of the aged transcriptome and genome to oncogenic stress in haematopoietic stem cells using single cell approaches
    Wellcome Trust
    2016 - 2018
     

Teaching

Kristina currently teaches on the Master for Cancer Sciences programme and is involved with Master of Research student training.


Publications

List by: Type | Date

Jump to: 2018 | 2017 | 2016 | 2015 | 2013 | 2012 | 2010 | 2009 | 2007 | 2003
Number of items: 15.

2018

Kirschner, K. , Krueger, F., Green, A. R. and Chandra, T. (2018) Multiplexing for oxidative bisulfite sequencing (oxBS-seq). In: Tost, J. (ed.) DNA Methylation Protocols. Series: Methods in molecular biology, 1708 (1708). Humana Press: New York, pp. 665-678. ISBN 9781493974795 (doi:10.1007/978-1-4939-7481-8_34)

2017

Baran-Gale, J., Chandra, T. and Kirschner, K. (2017) Experimental design for single-cell RNA sequencing. Briefings in Functional Genomics, (doi:10.1093/bfgp/elx035) (PMID:29126257) (Early Online Publication)

Kirschner, K. et al. (2017) Proliferation drives aging-related functional decline in a subpopulation of the hematopoietic stem cell compartment. Cell Reports, 19(8), pp. 1503-1511. (doi:10.1016/j.celrep.2017.04.074) (PMID:28538171) (PMCID:PMC5457484)

Kiselev, V. Y. et al. (2017) SC3: consensus clustering of single cell RNA-seq data. Nature Methods, 14(5), pp. 483-486. (doi:10.1038/nmeth.4236) (PMID:28346451)

2016

Chandra, T. and Kirschner, K. (2016) Chromosome organisation during ageing and senescence. Current Opinion in Cell Biology, 40, pp. 161-167. (doi:10.1016/j.ceb.2016.03.020) (PMID:27101466)

Park, H. J., Li, J., Hannah, R., Biddie, S., Leal‐Cervantes, A. I., Kirschner, K. , Flores Santa Cruz, D., Sexl, V., Göttgens, B. and Green, A. R. (2016) Cytokine‐induced megakaryocytic differentiation is regulated by genome‐wide loss of a uSTAT transcriptional program. EMBO Journal, 35(6), pp. 580-594. (doi:10.15252/embj.201592383) (PMID:26702099) (PMCID:PMC4801948)

2015

Kirschner, K. et al. (2015) Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53. PLoS Genetics, 11(3), e1005053. (doi:10.1371/journal.pgen.1005053) (PMID:25790137) (PMCID:PMC4366240)

Chandra, T., Ewels, P. A., Schoenfelder, S., Furlan-Magaril, M., Wingett, S. W., Kirschner, K. , Thuret, J.-Y., Andrews, S., Fraser, P. and Reik, W. (2015) Global reorganization of the nuclear landscape in senescent cells. Cell Reports, 10(4), pp. 471-483. (doi:10.1016/j.celrep.2014.12.055) (PMID:25640177) (PMCID:PMC4542308)

2013

Kent, D. G. et al. (2013) Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion. PLoS Biology, 11(6), e1001576. (doi:10.1371/journal.pbio.1001576) (PMID:23750118) (PMCID:PMC3672217)

Ward, M. C. et al. (2013) Latent regulatory potential of human-specific repetitive elements. Molecular Cell, 49(2), pp. 262-272. (doi:10.1016/j.molcel.2012.11.013) (PMID:23246434) (PMCID:PMC3560060)

2012

Chandra, T. et al. (2012) Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Molecular Cell, 47(2), pp. 203-214. (doi:10.1016/j.molcel.2012.06.010) (PMID:22795131) (PMCID:PMC3701408)

2010

Kirschner, K. and Melton, D. W. (2010) Multiple roles of the ERCC1-XPF endonuclease in DNA repair and resistance to anticancer drugs. Anticancer Research, 30(9), pp. 3223-3232. (PMID:20944091)

2009

Young, A. R.J. et al. (2009) Autophagy mediates the mitotic senescence transition. Genes and Development, 23(7), pp. 798-803. (doi:10.1101/gad.519709) (PMID:19279323) (PMCID:PMC2666340)

2007

Kirschner, K. , Singh, R., Prost, S. and Melton, D. W. (2007) Characterisation of Ercc1 deficiency in the liver and in conditional Ercc1-deficient primary hepatocytes in vitro. DNA Repair, 6(3), pp. 304-316. (doi:10.1016/j.dnarep.2006.10.020) (PMID:17126084)

2003

Gunnarsson, C., Ahnström, M., Kirschner, K. , Olsson, B., Nordenskjöld, B., Rutqvist, L. E., Skoog, L. and Stål, O. (2003) Amplification of HSD17B1 and ERBB2 in primary breast cancer. Oncogene, 22(1), pp. 34-40. (doi:10.1038/sj.onc.1206078) (PMID:12527905)

This list was generated on Tue Aug 21 14:57:02 2018 BST.
Number of items: 15.

Articles

Baran-Gale, J., Chandra, T. and Kirschner, K. (2017) Experimental design for single-cell RNA sequencing. Briefings in Functional Genomics, (doi:10.1093/bfgp/elx035) (PMID:29126257) (Early Online Publication)

Kirschner, K. et al. (2017) Proliferation drives aging-related functional decline in a subpopulation of the hematopoietic stem cell compartment. Cell Reports, 19(8), pp. 1503-1511. (doi:10.1016/j.celrep.2017.04.074) (PMID:28538171) (PMCID:PMC5457484)

Kiselev, V. Y. et al. (2017) SC3: consensus clustering of single cell RNA-seq data. Nature Methods, 14(5), pp. 483-486. (doi:10.1038/nmeth.4236) (PMID:28346451)

Chandra, T. and Kirschner, K. (2016) Chromosome organisation during ageing and senescence. Current Opinion in Cell Biology, 40, pp. 161-167. (doi:10.1016/j.ceb.2016.03.020) (PMID:27101466)

Park, H. J., Li, J., Hannah, R., Biddie, S., Leal‐Cervantes, A. I., Kirschner, K. , Flores Santa Cruz, D., Sexl, V., Göttgens, B. and Green, A. R. (2016) Cytokine‐induced megakaryocytic differentiation is regulated by genome‐wide loss of a uSTAT transcriptional program. EMBO Journal, 35(6), pp. 580-594. (doi:10.15252/embj.201592383) (PMID:26702099) (PMCID:PMC4801948)

Kirschner, K. et al. (2015) Phenotype specific analyses reveal distinct regulatory mechanism for chronically activated p53. PLoS Genetics, 11(3), e1005053. (doi:10.1371/journal.pgen.1005053) (PMID:25790137) (PMCID:PMC4366240)

Chandra, T., Ewels, P. A., Schoenfelder, S., Furlan-Magaril, M., Wingett, S. W., Kirschner, K. , Thuret, J.-Y., Andrews, S., Fraser, P. and Reik, W. (2015) Global reorganization of the nuclear landscape in senescent cells. Cell Reports, 10(4), pp. 471-483. (doi:10.1016/j.celrep.2014.12.055) (PMID:25640177) (PMCID:PMC4542308)

Kent, D. G. et al. (2013) Self-renewal of single mouse hematopoietic stem cells is reduced by JAK2V617F without compromising progenitor cell expansion. PLoS Biology, 11(6), e1001576. (doi:10.1371/journal.pbio.1001576) (PMID:23750118) (PMCID:PMC3672217)

Ward, M. C. et al. (2013) Latent regulatory potential of human-specific repetitive elements. Molecular Cell, 49(2), pp. 262-272. (doi:10.1016/j.molcel.2012.11.013) (PMID:23246434) (PMCID:PMC3560060)

Chandra, T. et al. (2012) Independence of repressive histone marks and chromatin compaction during senescent heterochromatic layer formation. Molecular Cell, 47(2), pp. 203-214. (doi:10.1016/j.molcel.2012.06.010) (PMID:22795131) (PMCID:PMC3701408)

Kirschner, K. and Melton, D. W. (2010) Multiple roles of the ERCC1-XPF endonuclease in DNA repair and resistance to anticancer drugs. Anticancer Research, 30(9), pp. 3223-3232. (PMID:20944091)

Young, A. R.J. et al. (2009) Autophagy mediates the mitotic senescence transition. Genes and Development, 23(7), pp. 798-803. (doi:10.1101/gad.519709) (PMID:19279323) (PMCID:PMC2666340)

Kirschner, K. , Singh, R., Prost, S. and Melton, D. W. (2007) Characterisation of Ercc1 deficiency in the liver and in conditional Ercc1-deficient primary hepatocytes in vitro. DNA Repair, 6(3), pp. 304-316. (doi:10.1016/j.dnarep.2006.10.020) (PMID:17126084)

Gunnarsson, C., Ahnström, M., Kirschner, K. , Olsson, B., Nordenskjöld, B., Rutqvist, L. E., Skoog, L. and Stål, O. (2003) Amplification of HSD17B1 and ERBB2 in primary breast cancer. Oncogene, 22(1), pp. 34-40. (doi:10.1038/sj.onc.1206078) (PMID:12527905)

Book Sections

Kirschner, K. , Krueger, F., Green, A. R. and Chandra, T. (2018) Multiplexing for oxidative bisulfite sequencing (oxBS-seq). In: Tost, J. (ed.) DNA Methylation Protocols. Series: Methods in molecular biology, 1708 (1708). Humana Press: New York, pp. 665-678. ISBN 9781493974795 (doi:10.1007/978-1-4939-7481-8_34)

This list was generated on Tue Aug 21 14:57:02 2018 BST.