Dr Karen Keeshan

  • Reader (Paul O'Gorman Leukaemia Research Centre)

Publications

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Number of items: 60.

2019

Smith, E. L., Somma, D., Kerrigan, D., McIntyre, Z., Cole, J. J., Liang, K. L., Kiely, P. A., Keeshan, K. and Carmody, R. J. (2019) The regulation of sequence specific NF-ĸB DNA binding and transcription by IKKβ Phosphorylation of NF-ĸB p50 at Serine 80. Nucleic Acids Research, 47(21), pp. 11151-11161. (doi:10.1093/nar/gkz873) (PMID:31598684)

Richmond, L. and Keeshan, K. (2019) Pseudokinases: a tribble‐edged sword. FEBS Journal, (doi:10.1111/febs.15096) (Early Online Publication)

Mussai, F. et al. (2019) Targeting the arginine metabolic brake enhances immunotherapy for leukaemia. International Journal of Cancer, 145(8), pp. 2201-2208. (doi:10.1002/ijc.32028) (PMID:30485425) (PMCID:PMC6767531)

2018

Chaudhury, S. et al. (2018) Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias. Nature Communications, 9, 5280. (doi:10.1038/s41467-018-07584-1) (PMID:30538250) (PMCID:PMC6290074)

Salomé, M. , Hopcroft, L. and Keeshan, K. (2018) Inverse and correlative relationships between TRIBBLES genes indicate non-redundant functions during normal and malignant hemopoiesis. Experimental Hematology, 66, 63-78.e13. (doi:10.1016/j.exphem.2018.07.005) (PMID:30031847)

Foulkes, D. M. et al. (2018) Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells. Science Signaling, 11(549), eaat7951. (doi:10.1126/scisignal.aat7951) (PMID:30254057) (PMCID:PMC6553640)

Newcombe, A. A., Gibson, B. E.S. and Keeshan, K. (2018) Harnessing the potential of epigenetic therapies for childhood acute myeloid leukemia. Experimental Hematology, 63, pp. 1-11. (doi:10.1016/j.exphem.2018.03.008) (PMID:29608923)

Salomé, M. , Magee, A., Yalla, K., Chaudhury, S. , Sarrou, E. , Carmody, R. J. and Keeshan, K. (2018) A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling. Cell Death and Disease, 9(5), 443. (doi:10.1038/s41419-018-0467-3) (PMID:29670085) (PMCID:PMC5906628)

O'Connor, C., Yalla, K., Salome, M. , Moka, H. A., Gómez Castañeda, E., Eyers, P. A. and Keeshan, K. (2018) Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant acute myeloid leukaemia linked to elevated Bcl2. Oncotarget, 9(19), pp. 14977-14992. (doi:10.18632/oncotarget.24525) (PMID:29599919) (PMCID:PMC5871090)

2017

Laing, A. A., Harrison, C. J., Gibson, B. E.S. and Keeshan, K. (2017) Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukaemia. Experimental Hematology, 54, pp. 40-50. (doi:10.1016/j.exphem.2017.06.007) (PMID:28668350)

Sarrou, E. , Gibson, B. and Keeshan, K. (2017) Absence of Mcm6 mimics haemopoietic ageing and has implications for leukaemic transformation. 46th Annual Scientific Meeting of the ISEH - International Society for Experimental Hematology, Frankfurt, Germany, 24-27 Aug 2017. S69. (doi:10.1016/j.exphem.2017.06.134)

Carmody, R. and Keeshan, K. (2017) The Tribble with APL: a new road to therapy. Cancer Cell, 31(5), pp. 612-613. (doi:10.1016/j.ccell.2017.04.011) (PMID:28486101)

Eyers, P. A., Keeshan, K. and Kannan, N. (2017) Tribbles in the 21st Century: the evolving roles of Tribbles pseudokinases in biology and disease. Trends in Cell Biology, 27(4), pp. 284-298. (doi:10.1016/j.tcb.2016.11.002) (PMID:27908682) (PMCID:PMC5382568)

Ahmed, A., Wan, X., Mitxitorena, I., Lindsay, A. J., Pandolfi, P. P., McCaffrey, M. W., Keeshan, K. , Chen, Y. H. and Carmody, R. J. (2017) Regulation of NF-κB by PML and PML-RARα. Scientific Reports, 7, 44539. (doi:10.1038/srep44539) (PMID:28317833) (PMCID:PMC5357907)

2016

Chaudhury, S. S. , Wheadon, H. , Gibson, B. and Keeshan, K. (2016) The Bone Marrow Niche Distinguishes Young and Old Leukemia. 58th ASH Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.

O'Connor, C. et al. (2016) The presence of C/EBPα and its degradation are both required for TRIB2 mediated leukaemia. Oncogene, 35(40), pp. 5272-5281. (doi:10.1038/onc.2016.66) (PMID:26996668)

Keeshan, K. , Vieugué, P., Chaudhury, S. , Rishi, L., Gaillard, C., LIang, L., Garcia, E., Nakumura, T., Omidvar, N. and Kogan, S. C. (2016) Co-operative leukaemogenesis in acute myeloid leukaemia and acute promyelocytic leukaemia reveal C/EBPα as a common target of TRIB1 and PML/RARA. Haematologica, 101(10), pp. 1228-1236. (doi:10.3324/haematol.2015.138503) (PMID:27390356) (PMCID:PMC5046652)

Liang, K. L., Paredes, R., Carmody, R. , Eyers, P. A., Meyer, S., McCarthy, T. V. and Keeshan, K. (2016) Human TRIB2 oscillates during the cell cycle and promotes ubiquitination and degradation of CDC25C. International Journal of Molecular Sciences, 17(9), 1378. (doi:10.3390/ijms17091378) (PMID:27563873) (PMCID:PMC5037658)

Chaudhury, S. , Gibson, B. and Keeshan, K. (2016) The Impact of Cellular Age on Leukaemic Transformation. 21st Congress Of The European Hematology Association, Copenhagen, Denmark, 9-12 June 2016. p. 12.

Salomè, M. and Keeshan, K. (2016) TRIB2 Regulates the Cell Cycle Under Stress Conditions in a Murine Cell Model of Leukaemia. 21st Congress Of The European Hematology Association, Copenhagen, Denmark, 9-12 June 2016.

Sarrou, S., Gibson, B. and Keeshan, K. (2016) Efficient Genome Editing of Mouse Hematopoietic Cells Using Crispr/Cas9 Technology. 21st Congress Of The European Hematology Association, Copenhagen, Denmark, 9-12 June 2013. p. 295.

Yalla, K., O'Connor, C., Campos, J. and Keeshan, K. (2016) TRIB2 Transformed GMP is the Myeloid Leukaemia Initiating Cell. 21st Congress Of The European Hematology Association, Copenhagen, Denmark, 9-12 June 2016.

Liang, K. L., O'Connor, C., Veiga, J. P., McCarthy, T. V. and Keeshan, K. (2016) TRIB2 regulates normal and stress-induced thymocyte proliferation. Cell Discovery, 2, 15050. (doi:10.1038/celldisc.2015.50) (PMID:27462446) (PMCID:PMC4860960)

2015

Salome, M. , Campos, J. and Keeshan, K. (2015) TRIB2 and the ubiquitin proteasome system in cancer. Biochemical Society Transactions, 43(5), pp. 1089-1094. (doi:10.1042/bst20150103) (PMID:26517929)

Chaudhury, S. S. , Morison, J. K., Gibson, B. E.S. and Keeshan, K. (2015) Insights into cell ontogeny, age and acute myeloid leukaemia. Experimental Hematology, 43(9), pp. 745-755. (doi:10.1016/j.exphem.2015.05.008) (PMID:26051919)

Liang, K. L., O'Connor, C., McCarthy, T. V. and Keeshan, K. (2015) Investigation of the role of TRIB2 in normal murine hematopoiesis. Experimental Hematology, 43(9), S77. (doi:10.1016/j.exphem.2015.06.181)

Pellicano, F., O'Connor, C. and Keeshan, K. (2015) An investigation of the leukaemia initiating cell in TRIB2 mediated AML. Experimental Hematology, 43(9), S88. (doi:10.1016/j.exphem.2015.06.228)

O'Connor, C., Campos, J., Osinski, J. M., Gronostajski, R. M., Michie, A. and Keeshan, K. (2015) Nfix expression critically modulates early B lymphopoiesis and myelopoiesis. PLoS ONE, 10(3), e0120102. (doi:10.1371/journal.pone.0120102) (PMID:25780920) (PMCID:PMC4363787)

Latif, A.-L., Cole, J., Monteiro Campos, J., Clark, W., McGarry, L., Brock, C., Newcombe, A., Keeshan, K. , Copland, M. and Adams, P. (2015) Dual inhibition of MDM2 and BET cooperate to eradicate acute myeloid leukemia. Blood, 126(23), p. 674.

2014

Lohan, F., O'Connor, C., Campos, J., Ohlsson, E., Salome, M. , Forde, C., Cahill, M., Kiely, P., Porse, B. and Keeshan, K. (2014) Targeting C/EBPalpha p42 and oncogene cooperativity in acute myeloid leukaemia. Experimental Hematology, 42(8), S42. (doi:10.1016/j.exphem.2014.07.153)

O'Connor, C., Campos, J., Murphy, B., Hannon, M., Gronostajski, R., Michie, A. and Keeshan, K. (2014) NFIX influences stem and progenitor lineage fate. Experimental Hematology, 42(8), S54. (doi:10.1016/j.exphem.2014.07.205)

Ni Ealaithe, C., Rishi, L. and Keeshan, K. (2014) Analysis of Trib genes in leukaemia. Irish Journal of Medical Science, 183(S4), S133-S134. (doi:10.1007/s11845-014-1153-9)

Rishi, L. et al. (2014) Regulation of Trib2 by an E2F1-C/EBP feedback loop in AML cell proliferation. Blood, 123(15), pp. 2389-2400. (doi:10.1182/blood-2013-07-511683)

Walsh, S., Gavin, A., Wyatt, S., O'Connor, C., Keeshan, K. , Nolan, Y. M., O'Keeffe, G. W. and Sullivan, A. M. (2014) Knockdown of interleukin-1 receptor 1 is not neuroprotective in the 6-hydroxydopamine striatal lesion rat model of Parkinson's disease. International Journal of Neuroscience, 125(1), pp. 70-77. (doi:10.3109/00207454.2014.904304)

2013

Lohan, F. et al. (2013) Elucidation and therapeutic targeting of the molecular mechanism of TRIB2-mediated acute myeloid leukaemia. Blood, 122(21), p. 3792.

Ryan, S.M., O’Keeffe, G.W., O'Connor, C., Keeshan, K. and Nolan, Y.M. (2013) Negative regulation of TLX by IL-1β correlates with an inhibition of adult hippocampal neural precursor cell proliferation. Brain, Behavior, and Immunity, 33, pp. 7-13. (doi:10.1016/j.bbi.2013.03.005)

Keeshan, K. , Hannon, M., Rishi, L., Hasemann, M., Frank, A.-K., Timoney, J., O'Connor, C., Cahill, M. and Porse, B. (2013) E2F1 positively regulates Trib2 pseudokinase expression and proliferation in acute leukaemia. Experimental Hematology, 41(8), S50. (doi:10.1016/j.exphem.2013.05.197)

Keeshan, K. , O'Connor, C., Campos, J., Murphy, B., Hannon, M. and Michie, A. (2013) NFIX expression critically modulates early B lymphopoiesis and myelopoiesis. Experimental Hematology, 41(8), S68. (doi:10.1016/j.exphem.2013.05.267)

Liang, K.L., Rishi, L. and Keeshan, K. (2013) Tribbles in acute leukemia. Blood, 121(21), pp. 4265-4270. (doi:10.1182/blood-2012-12-471300)

Lohan, F. and Keeshan, K. (2013) The functionally diverse roles of tribbles. Biochemical Society Transactions, 41(4), pp. 1096-1100. (doi:10.1042/BST20130105)

2012

Hannon, M., Lohan, F., Erbilgin, Y., Sayitoglu, M., O’Hagan, K., Mills, K., Ozbek, U. and Keeshan, K. (2012) Elevated TRIB2 with NOTCH1 activation in paediatric/adult T-ALL. British Journal of Haematology, 158(5), pp. 626-634. (doi:10.1111/j.1365-2141.2012.09222.x)

Lohan, F. M. and Keeshan, K. (2012) Mechanism of Trib2 mediated degradation of C/EBP-ain acute myelogenous leukaemia. British Journal of Haematology, 157(S1), p. 57. (doi:10.1111/j.1365-2141.2012.09071.x)

Keeshan, K. (2012) Elevated Trib2 with Notch1 activation in pediatric/adult T-ALL. In: British Society for Haematology 52nd Annual Scientific Meeting, Glasgow, 16-18 April 2012,

2011

Hannon, M., Al-Shahrour, F., Ebert, B. L. and Keeshan, K. (2011) Regulation of Trib2 gene expression in normal and AML cells. British Journal of Haematology, 153(Supl 1), pp. 6-7. (doi:10.1111/j.1365-2141.2011.08609.x)

The Trustees of the University Of Pennsylvania (2011) Diagnostic and Therapeutic Utility of Tribbles-2 in Human Cancers. .

2010

Keeshan, K. (2010) 643 Degradation of C/EBPalpha by Trib proteins correlates with Trib mediated acute myeloid leukemia. European Journal of Cancer Supplements, 8(5), pp. 162-163. (doi:10.1016/S1359-6349(10)71443-9)

Dedhia, P.H., Keeshan, K. , Uljon, S., Xu, L., Vega, M.E., Shestova, O., Zaks-Zilberman, M., Romany, C., Blacklow, S.C. and Pear, W.S. (2010) Differential ability of Tribbles family members to promote degradation of C/EBP and induce acute myelogenous leukemia. Blood, 116(8), pp. 1321-1328. (doi:10.1182/blood-2009-07-229450)

Keeshan, K. , Bailis, W., Dedhia, P. H., Vega, M. E., Shestova, O., Xu, L., Toscano, K., Uljon, S. N., Blacklow, S. C. and Pear, W. S. (2010) Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding. Blood, 116(23), pp. 4948-4957. (doi:10.1182/blood-2009-10-247361)

2008

Keeshan, K. , Shestova, O., Ussin, L. and Pear, W.S. (2008) Tribbles homolog 2 (Trib2) and HoxA9 cooperate to accelerate acute myelogenous leukemia. Blood Cells, Molecules, and Diseases, 40(1), pp. 119-121. (doi:10.1016/j.bcmd.2007.06.005)

2007

Wouters, B.J. et al. (2007) Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. Blood, 110(10), pp. 3706-3714. (doi:10.1182/blood-2007-02-073486)

2006

Chen, Y.-X., Yan, J., Keeshan, K. , Tubbs, A.T., Wang, H., Silva, A., Brown, E.J., Hess, J.L., Pear, W.S. and Hua, X. (2006) The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Proceedings of the National Academy of Sciences of the United States of America, 103(4), pp. 1018-1023. (doi:10.1073/pnas.0510347103)

Ferrari-Amorotti, G., Keeshan, K. , Zattoni, M., Guerzoni, C., Iotti, G., Cattelani, S., Donato, N.J. and Calabretta, B. (2006) Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBP. Blood, 108(4), pp. 1353-1362. (doi:10.1182/blood-2006-01-011833)

Keeshan, K. et al. (2006) Tribbles homolog 2 inactivates C/EBPα and causes acute myelogenous leukemia. Cancer Cell, 10(5), pp. 401-411. (doi:10.1016/j.ccr.2006.09.012)

Keeshan, K. et al. (2006) Tribbles homolog 2 (Trib2) inactivates C/EBPalpha and causes acute myelogenous leukemia. Blood, 108(11), p. 776.

Maillard, I., Tu, L., Sambandam, A., Yashiro-Ohtani, Y., Millholland, J., Keeshan, K. , Shestova, O., Xu, L., Bhandoola, A. and Pear, W. S. (2006) The requirement for Notch signaling at the -selection checkpoint in vivo is absolute and independent of the pre-T cell receptor. Journal of Experimental Medicine, 203(10), pp. 2239-2245. (doi:10.1084/jem.20061020)

2003

Keeshan, K. (2003) Transcription activation function of C/EBP is required for induction of granulocytic differentiation. Blood, 102(4), pp. 1267-1275. (doi:10.1182/blood-2003-02-0477)

Keeshan, K. , Cotter, T.G. and McKenna, S.L. (2003) Bcr-Abl upregulates cytosolic p21WAF-1/CIP-1by a phosphoinositide-3-kinase (PI3K)-independent pathway. British Journal of Haematology, 123(1), pp. 34-44. (doi:10.1046/j.1365-2141.2003.04538.x)

2002

Keeshan, K. , Cotter, T.G. and McKenna, S.L. (2002) High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion. Leukemia, 16(9), pp. 1725-34.

2001

Keeshan, K. , Mills, K.I., Cotter, T.G. and McKenna, S.L. (2001) Elevated Bcr-Abl expression levels are sufficient for a haematopoietic cell line to acquire a drug-resistant phenotype. Leukemia, 15(12), pp. 1823-1833.

2000

Di Bacco, A., Keeshan, K. , McKenna, S. L. and Cotter, T. G. (2000) Molecular abnormalities in chronic myeloid leukemia: deregulation of cell growth and apoptosis. Oncologist, 5(5), pp. 405-415. (doi:10.1634/theoncologist.5-5-405) (PMID:11040277)

This list was generated on Sun Dec 15 20:23:42 2019 GMT.
Number of items: 60.

Articles

Smith, E. L., Somma, D., Kerrigan, D., McIntyre, Z., Cole, J. J., Liang, K. L., Kiely, P. A., Keeshan, K. and Carmody, R. J. (2019) The regulation of sequence specific NF-ĸB DNA binding and transcription by IKKβ Phosphorylation of NF-ĸB p50 at Serine 80. Nucleic Acids Research, 47(21), pp. 11151-11161. (doi:10.1093/nar/gkz873) (PMID:31598684)

Richmond, L. and Keeshan, K. (2019) Pseudokinases: a tribble‐edged sword. FEBS Journal, (doi:10.1111/febs.15096) (Early Online Publication)

Mussai, F. et al. (2019) Targeting the arginine metabolic brake enhances immunotherapy for leukaemia. International Journal of Cancer, 145(8), pp. 2201-2208. (doi:10.1002/ijc.32028) (PMID:30485425) (PMCID:PMC6767531)

Chaudhury, S. et al. (2018) Age-specific biological and molecular profiling distinguishes paediatric from adult acute myeloid leukaemias. Nature Communications, 9, 5280. (doi:10.1038/s41467-018-07584-1) (PMID:30538250) (PMCID:PMC6290074)

Salomé, M. , Hopcroft, L. and Keeshan, K. (2018) Inverse and correlative relationships between TRIBBLES genes indicate non-redundant functions during normal and malignant hemopoiesis. Experimental Hematology, 66, 63-78.e13. (doi:10.1016/j.exphem.2018.07.005) (PMID:30031847)

Foulkes, D. M. et al. (2018) Covalent inhibitors of EGFR family protein kinases induce degradation of human Tribbles 2 (TRIB2) pseudokinase in cancer cells. Science Signaling, 11(549), eaat7951. (doi:10.1126/scisignal.aat7951) (PMID:30254057) (PMCID:PMC6553640)

Newcombe, A. A., Gibson, B. E.S. and Keeshan, K. (2018) Harnessing the potential of epigenetic therapies for childhood acute myeloid leukemia. Experimental Hematology, 63, pp. 1-11. (doi:10.1016/j.exphem.2018.03.008) (PMID:29608923)

Salomé, M. , Magee, A., Yalla, K., Chaudhury, S. , Sarrou, E. , Carmody, R. J. and Keeshan, K. (2018) A Trib2-p38 axis controls myeloid leukaemia cell cycle and stress response signalling. Cell Death and Disease, 9(5), 443. (doi:10.1038/s41419-018-0467-3) (PMID:29670085) (PMCID:PMC5906628)

O'Connor, C., Yalla, K., Salome, M. , Moka, H. A., Gómez Castañeda, E., Eyers, P. A. and Keeshan, K. (2018) Trib2 expression in granulocyte-monocyte progenitors drives a highly drug resistant acute myeloid leukaemia linked to elevated Bcl2. Oncotarget, 9(19), pp. 14977-14992. (doi:10.18632/oncotarget.24525) (PMID:29599919) (PMCID:PMC5871090)

Laing, A. A., Harrison, C. J., Gibson, B. E.S. and Keeshan, K. (2017) Unlocking the potential of anti-CD33 therapy in adult and childhood acute myeloid leukaemia. Experimental Hematology, 54, pp. 40-50. (doi:10.1016/j.exphem.2017.06.007) (PMID:28668350)

Carmody, R. and Keeshan, K. (2017) The Tribble with APL: a new road to therapy. Cancer Cell, 31(5), pp. 612-613. (doi:10.1016/j.ccell.2017.04.011) (PMID:28486101)

Eyers, P. A., Keeshan, K. and Kannan, N. (2017) Tribbles in the 21st Century: the evolving roles of Tribbles pseudokinases in biology and disease. Trends in Cell Biology, 27(4), pp. 284-298. (doi:10.1016/j.tcb.2016.11.002) (PMID:27908682) (PMCID:PMC5382568)

Ahmed, A., Wan, X., Mitxitorena, I., Lindsay, A. J., Pandolfi, P. P., McCaffrey, M. W., Keeshan, K. , Chen, Y. H. and Carmody, R. J. (2017) Regulation of NF-κB by PML and PML-RARα. Scientific Reports, 7, 44539. (doi:10.1038/srep44539) (PMID:28317833) (PMCID:PMC5357907)

O'Connor, C. et al. (2016) The presence of C/EBPα and its degradation are both required for TRIB2 mediated leukaemia. Oncogene, 35(40), pp. 5272-5281. (doi:10.1038/onc.2016.66) (PMID:26996668)

Keeshan, K. , Vieugué, P., Chaudhury, S. , Rishi, L., Gaillard, C., LIang, L., Garcia, E., Nakumura, T., Omidvar, N. and Kogan, S. C. (2016) Co-operative leukaemogenesis in acute myeloid leukaemia and acute promyelocytic leukaemia reveal C/EBPα as a common target of TRIB1 and PML/RARA. Haematologica, 101(10), pp. 1228-1236. (doi:10.3324/haematol.2015.138503) (PMID:27390356) (PMCID:PMC5046652)

Liang, K. L., Paredes, R., Carmody, R. , Eyers, P. A., Meyer, S., McCarthy, T. V. and Keeshan, K. (2016) Human TRIB2 oscillates during the cell cycle and promotes ubiquitination and degradation of CDC25C. International Journal of Molecular Sciences, 17(9), 1378. (doi:10.3390/ijms17091378) (PMID:27563873) (PMCID:PMC5037658)

Liang, K. L., O'Connor, C., Veiga, J. P., McCarthy, T. V. and Keeshan, K. (2016) TRIB2 regulates normal and stress-induced thymocyte proliferation. Cell Discovery, 2, 15050. (doi:10.1038/celldisc.2015.50) (PMID:27462446) (PMCID:PMC4860960)

Salome, M. , Campos, J. and Keeshan, K. (2015) TRIB2 and the ubiquitin proteasome system in cancer. Biochemical Society Transactions, 43(5), pp. 1089-1094. (doi:10.1042/bst20150103) (PMID:26517929)

Chaudhury, S. S. , Morison, J. K., Gibson, B. E.S. and Keeshan, K. (2015) Insights into cell ontogeny, age and acute myeloid leukaemia. Experimental Hematology, 43(9), pp. 745-755. (doi:10.1016/j.exphem.2015.05.008) (PMID:26051919)

Liang, K. L., O'Connor, C., McCarthy, T. V. and Keeshan, K. (2015) Investigation of the role of TRIB2 in normal murine hematopoiesis. Experimental Hematology, 43(9), S77. (doi:10.1016/j.exphem.2015.06.181)

Pellicano, F., O'Connor, C. and Keeshan, K. (2015) An investigation of the leukaemia initiating cell in TRIB2 mediated AML. Experimental Hematology, 43(9), S88. (doi:10.1016/j.exphem.2015.06.228)

O'Connor, C., Campos, J., Osinski, J. M., Gronostajski, R. M., Michie, A. and Keeshan, K. (2015) Nfix expression critically modulates early B lymphopoiesis and myelopoiesis. PLoS ONE, 10(3), e0120102. (doi:10.1371/journal.pone.0120102) (PMID:25780920) (PMCID:PMC4363787)

Latif, A.-L., Cole, J., Monteiro Campos, J., Clark, W., McGarry, L., Brock, C., Newcombe, A., Keeshan, K. , Copland, M. and Adams, P. (2015) Dual inhibition of MDM2 and BET cooperate to eradicate acute myeloid leukemia. Blood, 126(23), p. 674.

Lohan, F., O'Connor, C., Campos, J., Ohlsson, E., Salome, M. , Forde, C., Cahill, M., Kiely, P., Porse, B. and Keeshan, K. (2014) Targeting C/EBPalpha p42 and oncogene cooperativity in acute myeloid leukaemia. Experimental Hematology, 42(8), S42. (doi:10.1016/j.exphem.2014.07.153)

O'Connor, C., Campos, J., Murphy, B., Hannon, M., Gronostajski, R., Michie, A. and Keeshan, K. (2014) NFIX influences stem and progenitor lineage fate. Experimental Hematology, 42(8), S54. (doi:10.1016/j.exphem.2014.07.205)

Ni Ealaithe, C., Rishi, L. and Keeshan, K. (2014) Analysis of Trib genes in leukaemia. Irish Journal of Medical Science, 183(S4), S133-S134. (doi:10.1007/s11845-014-1153-9)

Rishi, L. et al. (2014) Regulation of Trib2 by an E2F1-C/EBP feedback loop in AML cell proliferation. Blood, 123(15), pp. 2389-2400. (doi:10.1182/blood-2013-07-511683)

Walsh, S., Gavin, A., Wyatt, S., O'Connor, C., Keeshan, K. , Nolan, Y. M., O'Keeffe, G. W. and Sullivan, A. M. (2014) Knockdown of interleukin-1 receptor 1 is not neuroprotective in the 6-hydroxydopamine striatal lesion rat model of Parkinson's disease. International Journal of Neuroscience, 125(1), pp. 70-77. (doi:10.3109/00207454.2014.904304)

Lohan, F. et al. (2013) Elucidation and therapeutic targeting of the molecular mechanism of TRIB2-mediated acute myeloid leukaemia. Blood, 122(21), p. 3792.

Ryan, S.M., O’Keeffe, G.W., O'Connor, C., Keeshan, K. and Nolan, Y.M. (2013) Negative regulation of TLX by IL-1β correlates with an inhibition of adult hippocampal neural precursor cell proliferation. Brain, Behavior, and Immunity, 33, pp. 7-13. (doi:10.1016/j.bbi.2013.03.005)

Keeshan, K. , Hannon, M., Rishi, L., Hasemann, M., Frank, A.-K., Timoney, J., O'Connor, C., Cahill, M. and Porse, B. (2013) E2F1 positively regulates Trib2 pseudokinase expression and proliferation in acute leukaemia. Experimental Hematology, 41(8), S50. (doi:10.1016/j.exphem.2013.05.197)

Keeshan, K. , O'Connor, C., Campos, J., Murphy, B., Hannon, M. and Michie, A. (2013) NFIX expression critically modulates early B lymphopoiesis and myelopoiesis. Experimental Hematology, 41(8), S68. (doi:10.1016/j.exphem.2013.05.267)

Liang, K.L., Rishi, L. and Keeshan, K. (2013) Tribbles in acute leukemia. Blood, 121(21), pp. 4265-4270. (doi:10.1182/blood-2012-12-471300)

Lohan, F. and Keeshan, K. (2013) The functionally diverse roles of tribbles. Biochemical Society Transactions, 41(4), pp. 1096-1100. (doi:10.1042/BST20130105)

Hannon, M., Lohan, F., Erbilgin, Y., Sayitoglu, M., O’Hagan, K., Mills, K., Ozbek, U. and Keeshan, K. (2012) Elevated TRIB2 with NOTCH1 activation in paediatric/adult T-ALL. British Journal of Haematology, 158(5), pp. 626-634. (doi:10.1111/j.1365-2141.2012.09222.x)

Lohan, F. M. and Keeshan, K. (2012) Mechanism of Trib2 mediated degradation of C/EBP-ain acute myelogenous leukaemia. British Journal of Haematology, 157(S1), p. 57. (doi:10.1111/j.1365-2141.2012.09071.x)

Hannon, M., Al-Shahrour, F., Ebert, B. L. and Keeshan, K. (2011) Regulation of Trib2 gene expression in normal and AML cells. British Journal of Haematology, 153(Supl 1), pp. 6-7. (doi:10.1111/j.1365-2141.2011.08609.x)

Keeshan, K. (2010) 643 Degradation of C/EBPalpha by Trib proteins correlates with Trib mediated acute myeloid leukemia. European Journal of Cancer Supplements, 8(5), pp. 162-163. (doi:10.1016/S1359-6349(10)71443-9)

Dedhia, P.H., Keeshan, K. , Uljon, S., Xu, L., Vega, M.E., Shestova, O., Zaks-Zilberman, M., Romany, C., Blacklow, S.C. and Pear, W.S. (2010) Differential ability of Tribbles family members to promote degradation of C/EBP and induce acute myelogenous leukemia. Blood, 116(8), pp. 1321-1328. (doi:10.1182/blood-2009-07-229450)

Keeshan, K. , Bailis, W., Dedhia, P. H., Vega, M. E., Shestova, O., Xu, L., Toscano, K., Uljon, S. N., Blacklow, S. C. and Pear, W. S. (2010) Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding. Blood, 116(23), pp. 4948-4957. (doi:10.1182/blood-2009-10-247361)

Keeshan, K. , Shestova, O., Ussin, L. and Pear, W.S. (2008) Tribbles homolog 2 (Trib2) and HoxA9 cooperate to accelerate acute myelogenous leukemia. Blood Cells, Molecules, and Diseases, 40(1), pp. 119-121. (doi:10.1016/j.bcmd.2007.06.005)

Wouters, B.J. et al. (2007) Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1. Blood, 110(10), pp. 3706-3714. (doi:10.1182/blood-2007-02-073486)

Chen, Y.-X., Yan, J., Keeshan, K. , Tubbs, A.T., Wang, H., Silva, A., Brown, E.J., Hess, J.L., Pear, W.S. and Hua, X. (2006) The tumor suppressor menin regulates hematopoiesis and myeloid transformation by influencing Hox gene expression. Proceedings of the National Academy of Sciences of the United States of America, 103(4), pp. 1018-1023. (doi:10.1073/pnas.0510347103)

Ferrari-Amorotti, G., Keeshan, K. , Zattoni, M., Guerzoni, C., Iotti, G., Cattelani, S., Donato, N.J. and Calabretta, B. (2006) Leukemogenesis induced by wild-type and STI571-resistant BCR/ABL is potently suppressed by C/EBP. Blood, 108(4), pp. 1353-1362. (doi:10.1182/blood-2006-01-011833)

Keeshan, K. et al. (2006) Tribbles homolog 2 inactivates C/EBPα and causes acute myelogenous leukemia. Cancer Cell, 10(5), pp. 401-411. (doi:10.1016/j.ccr.2006.09.012)

Keeshan, K. et al. (2006) Tribbles homolog 2 (Trib2) inactivates C/EBPalpha and causes acute myelogenous leukemia. Blood, 108(11), p. 776.

Maillard, I., Tu, L., Sambandam, A., Yashiro-Ohtani, Y., Millholland, J., Keeshan, K. , Shestova, O., Xu, L., Bhandoola, A. and Pear, W. S. (2006) The requirement for Notch signaling at the -selection checkpoint in vivo is absolute and independent of the pre-T cell receptor. Journal of Experimental Medicine, 203(10), pp. 2239-2245. (doi:10.1084/jem.20061020)

Keeshan, K. (2003) Transcription activation function of C/EBP is required for induction of granulocytic differentiation. Blood, 102(4), pp. 1267-1275. (doi:10.1182/blood-2003-02-0477)

Keeshan, K. , Cotter, T.G. and McKenna, S.L. (2003) Bcr-Abl upregulates cytosolic p21WAF-1/CIP-1by a phosphoinositide-3-kinase (PI3K)-independent pathway. British Journal of Haematology, 123(1), pp. 34-44. (doi:10.1046/j.1365-2141.2003.04538.x)

Keeshan, K. , Cotter, T.G. and McKenna, S.L. (2002) High Bcr-Abl expression prevents the translocation of Bax and Bad to the mitochondrion. Leukemia, 16(9), pp. 1725-34.

Keeshan, K. , Mills, K.I., Cotter, T.G. and McKenna, S.L. (2001) Elevated Bcr-Abl expression levels are sufficient for a haematopoietic cell line to acquire a drug-resistant phenotype. Leukemia, 15(12), pp. 1823-1833.

Di Bacco, A., Keeshan, K. , McKenna, S. L. and Cotter, T. G. (2000) Molecular abnormalities in chronic myeloid leukemia: deregulation of cell growth and apoptosis. Oncologist, 5(5), pp. 405-415. (doi:10.1634/theoncologist.5-5-405) (PMID:11040277)

Conference or Workshop Item

Sarrou, E. , Gibson, B. and Keeshan, K. (2017) Absence of Mcm6 mimics haemopoietic ageing and has implications for leukaemic transformation. 46th Annual Scientific Meeting of the ISEH - International Society for Experimental Hematology, Frankfurt, Germany, 24-27 Aug 2017. S69. (doi:10.1016/j.exphem.2017.06.134)

Chaudhury, S. S. , Wheadon, H. , Gibson, B. and Keeshan, K. (2016) The Bone Marrow Niche Distinguishes Young and Old Leukemia. 58th ASH Annual Meeting, San Diego, CA, USA, 3-6 Dec 2016.

Chaudhury, S. , Gibson, B. and Keeshan, K. (2016) The Impact of Cellular Age on Leukaemic Transformation. 21st Congress Of The European Hematology Association, Copenhagen, Denmark, 9-12 June 2016. p. 12.

Salomè, M. and Keeshan, K. (2016) TRIB2 Regulates the Cell Cycle Under Stress Conditions in a Murine Cell Model of Leukaemia. 21st Congress Of The European Hematology Association, Copenhagen, Denmark, 9-12 June 2016.

Sarrou, S., Gibson, B. and Keeshan, K. (2016) Efficient Genome Editing of Mouse Hematopoietic Cells Using Crispr/Cas9 Technology. 21st Congress Of The European Hematology Association, Copenhagen, Denmark, 9-12 June 2013. p. 295.

Yalla, K., O'Connor, C., Campos, J. and Keeshan, K. (2016) TRIB2 Transformed GMP is the Myeloid Leukaemia Initiating Cell. 21st Congress Of The European Hematology Association, Copenhagen, Denmark, 9-12 June 2016.

Conference Proceedings

Keeshan, K. (2012) Elevated Trib2 with Notch1 activation in pediatric/adult T-ALL. In: British Society for Haematology 52nd Annual Scientific Meeting, Glasgow, 16-18 April 2012,

Patents

The Trustees of the University Of Pennsylvania (2011) Diagnostic and Therapeutic Utility of Tribbles-2 in Human Cancers. .

This list was generated on Sun Dec 15 20:23:42 2019 GMT.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Investigation of CD33-targeted therapy in childhood acute myeloid leukaemia (AML)
    Glasgow Children`s Hospital Charity
    2016 - 2019
     
  • The influence of the microenvironment in paediatric AML
    Yorkhill Leukaemia & Cancer Research Fund
    2016 - 2018
     
  • Dissecting the function of Bcl-3 in NF-kappaB signaling in B cells
    Biotechnology and Biological Sciences Research Council
    2015 - 2018
     
  • The importance of stem cell ontogeny in paediatric and adult acute myeloid leukaemia
    Glasgow Children`s Hospital Charity
    2014 - 2016
     
  • Investigating leukaemic stem cell responses following CD33-targeted therapy and the implications for low and high risk paediatric AML groups
    Aila Coull Foundation
    2014 - 2015
     
  • Targeting Trib2 oncogenic signalling in normal and malignant stem cells.
    Bloodwise
    2013 - 2016
     


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