Professor Christian Delles

  • Professor (Institute of Cardiovascular & Medical Sciences)
  • Associate (School of Medicine, Dentistry & Nursing)

Biography

Christian Delles studied medicine at the Universities of Freiburg, Germany, and Innsbruck, Austria. He undertook his MD research in Prof Paul Dietl's lab at the Department of Physiology in Innsbruck and joined Prof. Roland Schmieder's group at the Department of Nephrology, University of Erlangen-Nürnberg, in 1997. Here he worked on renal haemodynamics in arterial hypertension, type 2 diabetes, and other diseases; pathophysiology of endothelial dysfunction; and pathophysiology of left ventricular hypertrophy. In parallel he completed his specialist training in Internal Medicine. He joined the BHF GCRC in 2003 as a Research Fellow funded by the Deutsche Forschungsgemeinschaft and became Senior Lecturer and Honorary Consultant Physician in 2005. He became a Reader at the Institute of Cardiovascular and Medical Sciences in 2011 and is currently Professor of Cardiovascular Prevention and Deputy Director of the BHF Centre of Excellence.  


Research interests

Leader: Vascular Research

Member: 

His interests are focussed on the pathophysiology of cardiovascular diseases where he uses clinical and translational approaches in his research.

Major interests include:

Biomarkers of cardiovascular disease and cardiovascular risk - Together with Prof. Anna Dominiczak, Prof. Delles co-ordinates the EU FP7 programme "EU-MASCARA" into novel biomarkers of cardiovascular disease and risk.

Vascular function and structure in patients at cardiovascular risk - The group uses a range of tools to characterise subclinical vascular damage, including flow-mediated dilation, peripheral artery tonometry, pulse wave analysis, assessment of pulse wave velocity and carotid intima-media thickness. There is close collaboration with the Clinical Research Facility at the Queen Elizabeth University Hospital and Prof. Delles leads the Vascular Core which is an integral part of the BHF Centre of Excellence.

Systems medicine of cardiovascular and renal diseases - Together with Prof. Harald Mischak, Prof. Delles studies proteomic and metabolomic profiles of coronary artery disease, chronic kidney disease and other cardiovascular disorders. These projects are supported by EU FP7 programmes including "sysVASC" and "HOMAGE".

Pathophysiology of pre-eclampsia and cardiovascular consequences of pre-eclampsia - This more recent research was triggered by findings on urinary proteomic profiles in pre-eclampsia in a large clinical study that was conducted together with Dr David Carty. Ongoing work on biomarkers of pre-eclampsia and studies into the cardiovascular consequences of pre-eclampsia of interest are conducted in collaboration with the Generation Scotland team and internationally with the Canadian Vascular Network.

Risk stratification and prevention of chronic diseases - Together with Prof Peter Rossing at the Steno Diabetes Center and 13 other international partners the Glasgow team led by Prof. Delles is a major partner of the EU FP7 programme "PRIORITY" to study early detection of diabetic nephropathy and stratified preventative therapy of patients at highest risk.

 


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Investigation of Uromodulin Polymerisation in Development And Progression Of Hypertension
    Academy of Medical Sciences
    2018 - 2019
     
  • Vaso-protective properties of maternal high density lipoprotein (HDL) in metabolic complications of pregnancy
    NHS Greater Glasgow and Clyde Endowment Funds
    2018 - 2019
     
  • Diabetes, Glucose Lowering and Preeclampsia Prevention: The Role of Vascular Function
    Glasgow Children`s Hospital Charity
    2017 - 2019
     
  • The African Prospective study on the Early Detection and Identification of Cardiovascular disease and Hypertension (African-PREDICT)
    Medical Research Council
    2016 - 2020
     
  • Combined Suppression of cholesterol bioavailability and androgen de novo syntheseis to treat castrate resistant prostate cancer
    Prostate Cancer UK
    2015 - 2019
     
  • Metabolite and protein profiling in CADASIL to unravel the vascular pathophysiology and natural history
    NHS Greater Glasgow and Clyde Endowment Funds
    2014 - 2016
     
  • Systems biology analysis of multi-omics data and development of integrative analysis methods for biomarkers and determinants of treatment-refractory severe asthma (ISSF Catalyst)
    Wellcome Trust
    2014 - 2015
     
  • Therapeutic manipulation of miR-214
    Medical Research Council
    2014 - 2015
     
  • BHF centre of excellence
    British Heart Foundation
    2014 - 2019
     
  • DISCHARGE
    European Commission
    2014 - 2019
     
  • SysVasc
    European Commission
    2014 - 2018
     
  • Studies into the role of microparticles in cardiovascular diseases
    Ministry of Education and Science of the Russian Federation
    2014 - 2014
     
  • Characterising vascular pathophysiology in CADASIL (cerebral autosomal dominant arteriopathy with subacute infarcts and leukoencephalopathy) by evaluation of gluteal resistance vessels
    Stroke Association
    2013 - 2016
     
  • IMODE-CKD: Clinical and system-omics for the identification of the Molecular Determinants of established Chronic Kidney Disease
    European Commission
    2013 - 2017
     
  • Understanding variability in phenotype, and assessing the risk of serious cardiac events, in women and children with long QT syndrome.
    Glasgow Children`s Hospital Charity
    2013 - 2015
     
  • HOMAGE: Heart OMics in AGEing
    European Commission
    2013 - 2019
     
  • Cerebral and peripheral perfusion and reactivity in CADASIL: a longitudinal pilot study
    Chief Scientist Office
    2013 - 2016
     
  • Cardiovascular consequences of preeclampsia in women from the Generation Scotland: Scottish Family Health Study.
    Chief Scientist Office
    2012 - 2015
     
  • Inhibition of vascular Stat Signalling by Amp-Activated Protein Kinase (AMPK).
    British Heart Foundation
    2012 - 2015
     
  • Serum phosphate as a cardiovascular risk factor: effects on vascular and endothelial function
    British Heart Foundation
    2012 - 2013
     
  • PRIORITY: Intervention study for the prevention of diabetic nephropathy
    European Commission
    2012 - 2017
     
  • EU-MASCARA - Biomarkers for Cardiovascular Disease
    European Commission
    2011 - 2015
     
  • Reversal of pro-inflammatory interleukin-6 signalling by cyclic AMP-mediated induction of suppressor of cytokine signalling-3(SOCS-3)
    Chest Heart and Stroke Scotland
    2010 - 2011
     
  • Euratrans
    European Commission
    2010 - 2014
     
  • InGenious HyperCare - Integrating Genomics, Clinical Research and Care in Hypertension
    European Commission
    2009 - 2010
     
  • Induced pluripoptent cells: analysis of cell reprogramming of dermal fibroblasts derived from patients with disease vs age-matched healthy controls
    British Heart Foundation
    2009 - 2012
     
  • Researcher Exchange from Faculdade de Medicina de Ribeirao Preto, Brazil
    British Council - Manchester
    2009 - 2009
     
  • EPAC1 and ERK-dependent activation of C/EBP transcription factors: a new cyclic AMP-activated anti-inflammatory gene expression module in vascular endothelial cells
    British Heart Foundation
    2009 - 2011
     
  • Collaborative strategy for a definitive genome scan in essential hypertension: high fidelity phenotyping and "hypercontrols"
    British Heart Foundation
    2008 - 2011
     
  • Genomics and proteomics of hypertension and its vascular complications: the pathwayomic strategies.
    British Heart Foundation
    2008 - 2011
     
  • Assessment of endothelial function in pregnancy: evaluation of a non-invasive method to analyse flow-mediated vasodilation
    NHS Greater Glasgow and Clyde Endowment Funds
    2008 - 2010
     
  • High throughput collaborative analysis of cardiovascular genes in 6000 hypertensives and 6000 controls
    British Heart Foundation
    2008 - 2009
     
  • Hydralazine in heart failure - a study of the mechanisms of action in human blood vessels
    British Heart Foundation
    2006 - 2009
     

Teaching

Prof. Delles teaches on hypertension and cardiovascular diseases including their pathogenesis at undergraduate and postgraduate level. He also provides tutorials and bedside teaching to MBChB students and acts as clinical and educational supervisor of MBChB students and Foundation doctors. He currently supervises or co-supervises 5 PhD students and a number of undergraduate and honours students.


Publications

List by: Type | Date

Jump to: 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001
Number of items: 199.

2018

Lucas-Herald, A. K., Zürbig, P., Mason, A., Kinning, E., Brown, C., Mansoorian, B., Mullen, W. , Ahmed, S. F. and Delles, C. (2018) Proteomic evidence of biological ageing in a child with a compound heterozygous ZMPSTE24 mutation. Proteomics Clinical Applications, (Accepted for Publication)

Rossitto, G., Touyz, R. M. , Petrie, M. C. and Delles, C. (2018) Much ado about N…atrium: modelling tissue sodium as a highly sensitive marker of subclinical and localised oedema. Clinical Science, (Accepted for Publication)

Sliz, E. et al. (2018) Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment. Circulation, 138(22), pp. 2499-2512. (PMID:30524137)

Dayan, N., Schlosser, K., Stewart, D. J., Delles, C. , Kaur, A. and Pilote, L. (2018) Circulating microRNAs implicate multiple atherogenic abnormalities in the long-term cardiovascular sequelae of preeclampsia. American Journal of Hypertension, 31(10), pp. 1093-1097. (doi:10.1093/ajh/hpy069) (PMID:29800045) (PMCID:PMC6132124)

Tofte, N. et al. (2018) Characteristics of high- and low-risk individuals in the PRIORITY study: urinary proteomics and mineralocorticoid receptor antagonism for prevention of diabetic nephropathy in Type 2 diabetes. Diabetic Medicine, 35(10), pp. 1375-1382. (doi:10.1111/dme.13669) (PMID:29781558)

Ravassa, S. et al. (2018) Biomarker-based phenotyping of myocardial fibrosis identifies patients with heart failure with preserved ejection fraction resistant to the beneficial effects of spironolactone: results from the Aldo-DHF trial. European Journal of Heart Failure, 20(9), pp. 1290-1299. (doi:10.1002/ejhf.1194) (PMID:29709099)

Gillis, K., Stevens, K. K., Bell, E., Patel, R. K., Jardine, A. G. , Morris, S. T.W., Schneider, M. P., Delles, C. and Mark, P. B. (2018) Ascorbic acid lowers central blood pressure and asymmetric dimethylarginine in chronic kidney disease. Clinical Kidney Journal, 11(4), pp. 532-539. (doi:10.1093/ckj/sfx158) (PMID:30094018) (PMCID:PMC6070083)

Kerr, D. M.I., Brooksbank, K. J.M., Taylor, R. G., Pinel, K., Rios, F. J., Touyz, R. M. and Delles, C. (2018) Acute effects of electronic and tobacco cigarettes on vascular and respiratory function in healthy volunteers: a cross-over study. Journal of Hypertension, (doi:10.1097/HJH.0000000000001890) (PMID:30063637) (Early Online Publication)

Moreton, F. C., Cullen, B. , Delles, C. , Santosh, C., Lopez Gonzalez, R., Dani, K. and Muir, K. W. (2018) Vasoreactivity in CADASIL: comparison to structural MRI and neuropsychology. Journal of Cerebral Blood Flow and Metabolism, 38(6), pp. 1085-1095. (doi:10.1177/0271678X17710375) (PMID:28537106)

Lygirou, V., Latosinska, A., Makridakis, M., Mullen, W. , Delles, C. , Schanstra, J. P., Zoidakis, J., Pieske, B., Mischak, H. and Vlahou, A. (2018) Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease. Journal of Translational Medicine, 16(1), 104. (doi:10.1186/s12967-018-1476-9) (PMID:29665821) (PMCID:PMC5905170)

Currie, G. E. et al. (2018) Urinary proteomics for prediction of mortality in patients with type 2 diabetes and microalbuminuria. Cardiovascular Diabetology, 17, 50. (doi:10.1186/s12933-018-0697-9) (PMID:29625564)

Delles, C. and Currie, G. (2018) Sex differences in hypertension and other cardiovascular diseases. Journal of Hypertension, 36(4), pp. 768-770. (doi:10.1097/HJH.0000000000001655) (PMID:29489615)

Delles, C. et al. (2018) Nuclear magnetic resonance-based metabolomics identifies phenylalanine as a novel predictor of incident heart failure hospitalisation: results from PROSPER and FINRISK 1997. European Journal of Heart Failure, 20, pp. 663-673. (doi:10.1002/ejhf.1076) (PMID:29226610)

Feng, Y.-M. et al. (2018) Glomerular function in relation to circulating adhesion molecules and inflammation markers in a general population. Nephrology Dialysis Transplantation, 33(3), pp. 426-435. (doi:10.1093/ndt/gfx256) (PMID:28992257)

Currie, G. and Delles, C. (2018) Blood pressure targets in the elderly. Journal of Hypertension, 36(2), pp. 234-236. (doi:10.1097/HJH.0000000000001576)

2017

Krochmal, M. et al. (2017) Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy. Scientific Reports, 7, 15160. (doi:10.1038/s41598-017-15359-9) (PMID:29123184) (PMCID:PMC5680307)

Pontillo, C. et al. (2017) Prediction of chronic kidney disease stage 3 by CKD273, a urinary proteomic biomarker. Kidney International Reports, 2(6), pp. 1066-1075. (doi:10.1016/j.ekir.2017.06.004) (PMID:29130072) (PMCID:PMC5669285)

Schmieder, R. E. et al. (2017) The effect of sacubitril/valsartan compared to olmesartan on cardiovascular remodelling in subjects with essential hypertension: the results of a randomized, double-blind, active-controlled study. European Heart Journal, 38(44), pp. 3308-3317. (doi:10.1093/eurheartj/ehx525) (PMID:29029087)

Kohli-Lynch, C.N., Boyd, K. , Briggs, A. and Delles, C. (2017) A Framework for the Cost-Effectiveness Analysis of Novel Biomarker Testing in Cardiovascular Disease. ISPOR 20th Annual European Congress, Glasgow, UK, 4-8 Nov 2017. A404-A405. (doi:10.1016/j.jval.2017.08.040)

Stevens, K., Denby, L., Patel, R. K., Mark, P. B. , Kettlewell, S., Smith, G. L. , Clancy, M. J., Delles, C. and Jardine, A. G. (2017) Deleterious effects of phosphate on vascular and endothelial function via disruption to the nitric oxide pathway. Nephrology Dialysis Transplantation, 32(10), pp. 1617-1627. (doi:10.1093/ndt/gfw252) (PMID:27448672)

Krochmal, M. et al. (2017) Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis. Scientific Reports, 7(1), 9091. (doi:10.1038/s41598-017-09393-w) (PMID:28831120) (PMCID:PMC5567309)

Currie, G. and Delles, C. (2017) Healthy vascular aging. Hypertension, 70(2), pp. 229-231. (doi:10.1161/HYPERTENSIONAHA.117.09122) (PMID:28559393)

Gajjala, P. R. et al. (2017) Proteomic-biostatistic integrated approach for finding the underlying molecular determinants of hypertension in human plasma. Hypertension, 70, pp. 412-419. (doi:10.1161/HYPERTENSIONAHA.116.08906) (PMID:28652472)

Small, H. Y., Cornelius, D. C., Guzik, T. J. and Delles, C. (2017) Natural killer cells in placentation and cancer: Implications for hypertension during pregnancy. Placenta, 56, pp. 59-64. (doi:10.1016/j.placenta.2017.03.003) (PMID:28318556)

Zhang, Z.‐Y. et al. (2017) Novel urinary peptidomic classifier predicts incident heart failure. Journal of the American Heart Association, 6(8), e005432. (doi:10.1161/JAHA.116.005432) (PMID:28784649) (PMCID:PMC5586413)

Knez, J. et al. (2017) Peripheral blood mitochondrial DNA content in relation to circulating metabolites and inflammatory markers: a population study. PLoS ONE, 12(7), e0181036. (doi:10.1371/journal.pone.0181036) (PMID:28704533) (PMCID:PMC5509283)

Neisius, U., Olson, E., Rossi, S. H., Ibrahim, H. A., Currie, G. , Dominiczak, A. and Delles, C. (2017) Evaluation of the systemic micro- and macrovasculature in stable angina: a case-control study. PLoS ONE, 12(5), e0178412. (doi:10.1371/journal.pone.0178412) (PMID:28542516) (PMCID:PMC5444845)

Jacobs, L. et al. (2017) Risk for incident heart failure: a subject-level meta-analysis from the Heart “OMics” in AGEing (HOMAGE) study. Journal of the American Heart Association, 6(5), e005231. (doi:10.1161/JAHA.116.005231) (PMID:28465299)

Mary, S., Small, H. Y., Siwy, J., Mullen, W. , Giri, A. and Delles, C. (2017) Polymerization-incompetent uromodulin in the pregnant stroke-prone spontaneously hypertensive rat. Hypertension, 69(5), pp. 910-918. (doi:10.1161/HYPERTENSIONAHA.116.08826) (PMID:28348009) (PMCID:PMC5389592)

Dominiczak, A. , Delles, C. and Padmanabhan, S. (2017) Genomics and precision medicine for clinicians and scientists in hypertension. Hypertension, 69(4), e10-e13. (doi:10.1161/HYPERTENSIONAHA.116.08252) (PMID:28193712)

Htun, N. M. et al. (2017) Prediction of acute coronary syndromes by urinary proteome analysis. PLoS ONE, 12(3), e0172036.. (doi:10.1371/journal.pone.0172036) (PMID:28273075) (PMCID:PMC5342174)

Carty, D. M., Doogan, F., Welsh, P. , Dominiczak, A. F. and Delles, C. (2017) Thyroid stimulating hormone (TSH) ≥2.5mU/l in early pregnancy: prevalence and subsequent outcomes. European Journal of Obstetrics and Gynecology and Reproductive Biology, 210, pp. 366-369. (doi:10.1016/j.ejogrb.2017.01.048) (PMID:28153744)

Currie, G. and Delles, C. (2017) The future of "omics" in hypertension. Canadian Journal of Cardiology, 33(5), pp. 601-610. (doi:10.1016/j.cjca.2016.11.023) (PMID:28161100) (PMCID:5417769)

Small, H. Y., Akehurst, C., Sharafetdinova, L., McBride, M. W. , McClure, J. D. , Robinson, S. W., Carty, D. M., Freeman, D. J. and Delles, C. (2017) HLA gene expression is altered in whole blood and placenta from women who later developed preeclampsia. Physiological Genomics, 49(3), pp. 193-200. (doi:10.1152/physiolgenomics.00106.2016) (PMID:28130428) (PMCID:PMC5374453)

Delles, C. and Husi, H. (2017) Systems biology approach in hypertension research. In: Touyz, R. M. and Schriffin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology, 1527. Springer: New York, pp. 69-79. ISBN 9781493966233 (doi:10.1007/978-1-4939-6625-7_6)

Delles, C. and Vanholder, R. (2017) Chronic kidney disease. Clinical Science, 131(3), pp. 225-226. (doi:10.1042/CS20160624) (PMID:28057893)

2016

Ferreira, J. P. et al. (2016) Renal function estimation and Cockroft–Gault formulas for predicting cardiovascular mortality in population-based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: the Heart ‘OMics’ in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives. BMC Medicine, 14, 181. (doi:10.1186/s12916-016-0731-2) (PMID:27829460) (PMCID:PMC5103492)

Rutherford, C. et al. (2016) Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling. Science Signaling, 9(453), ra109. (doi:10.1126/scisignal.aaf8566) (PMID:27919027)

Currie, G. and Delles, C. (2016) Urinary proteomics for diagnosis and monitoring of diabetic nephropathy. Current Diabetes Reports, 16(11), 104. (doi:10.1007/s11892-016-0798-3) (PMID:27658932)

Small, H. Y., Nosalski, R., Morgan, H., Beattie, E., Guzik, T., Graham, D. and Delles, C. (2016) The role of tumor necrosis factor-α and natural killer cells in uterine artery function and pregnancy outcome in the stroke prone spontaneously hypertensive rat. Hypertension, 68(5), pp. 1298-1307. (doi:10.1161/HYPERTENSIONAHA.116.07933) (PMID:27733586) (PMCID:PMC5058643)

Currie, G. , Matt, P. and Delles, C. (2016) Clinical cardiovascular proteomics. In: Agnetti, G., Lindsey, M. L. and Foster, D. B. (eds.) Manual of Cardiovascular Proteomics. Springer, pp. 389-414. ISBN 9783319318264 (doi:10.1007/978-3-319-31828-8_17)

Currie, G. et al. (2016) Effect of mineralocorticoid receptor antagonists on proteinuria and progression of chronic kidney disease: a systematic review and meta-analysis. BMC Nephrology, 17, 127. (doi:10.1186/s12882-016-0337-0) (PMID:27609359) (PMCID:PMC5015203)

Mordi, I., Mordi, N., Delles, C. and Tzemos, N. (2016) Endothelial dysfunction in human essential hypertension. Journal of Hypertension, 34(8), pp. 1464-1472. (doi:10.1097/hjh.0000000000000965) (PMID:27203578)

Currie, G. and Delles, C. (2016) Use of biomarkers in the evaluation and treatment of hypertensive patients. Current Hypertension Reports, 18(7), 54. (doi:10.1007/s11906-016-0661-6) (PMID:27221728)

Wan Sulaiman, W.N., Caslake, M.J., Delles, C. , Karlsson, H., Mulder, M.T., Graham, D. and Freeman, D.J. (2016) Does high-density lipoprotein protect vascular function in healthy pregnancy? Clinical Science, 130(7), pp. 491-497. (doi:10.1042/cs20150475) (PMID:26888561)

Eisele, N. et al. (2016) Placental expression of the angiogenic placental growth factor is stimulated by both aldosterone and simulated starvation. Placenta, 40, pp. 18-24. (doi:10.1016/j.placenta.2016.02.004) (PMID:27016778)

Neisius, U. et al. (2016) Urine proteomics in the diagnosis of stable angina. BMC Cardiovascular Disorders, 16, 70. (doi:10.1186/s12872-016-0246-y) (PMID:27095611) (PMCID:PMC483761)

Mullan, A., Delles, C. , Ferrell, W., Mullen, W. , Edwards, C. A. , McColl, J. H. , Roberts, S. A. and Lean, M. (2016) Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized trial. Atherosclerosis, 246, pp. 169-176. (doi:10.1016/j.atherosclerosis.2016.01.004) (PMID:26797134)

Currie, G. , Delles, C. , Touyz, R. M. , Staessen, J. A., Dominiczak, A. F. , Jennings, G. L. R. and Wang, J.-G. (2016) A woman with treatment-resistant hypertension. Hypertension, 67(2), pp. 243-250. (doi:10.1161/HYPERTENSIONAHA.115.06756) (PMID:26711735)

Small, H. Y., Currie, G. E. and Delles, C. (2016) Prostasin, proteases, and preeclampsia. Journal of Hypertension, 34(2), pp. 193-195. (doi:10.1097/hjh.0000000000000828) (PMID:26682786)

Small, H. Y., Morgan, H., Beattie, E., Griffin, S., Indahl, M., Delles, C. and Graham, D. (2016) Abnormal uterine artery remodelling in the stroke prone spontaneously hypertensive rat. Placenta, 37, pp. 34-44. (doi:10.1016/j.placenta.2015.10.022) (PMID:26612342) (PMCID:PMC4721537)

Gillis, K. A., Mccomb, C., Patel, R. K., Stevens, K. K., Schneider, M. P., Radjenovic, A. , Morris, S. T.W., Roditi, G. H., Delles, C. and Mark, P. B. (2016) Non-contrast renal magnetic resonance imaging to assess perfusion and corticomedullary differentiation in health and chronic kidney disease. Nephron, 133(3), pp. 183-192. (doi:10.1159/000447601) (PMID:27362585)

Lindhardt, M. et al. (2016) Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic nephRopathy in TYpe 2 diabetic patients with normoalbuminuria (PRIORITY): essential study design and rationale of a randomised clinical multicentre trial. BMJ Open, 6(3), e010310. (doi:10.1136/bmjopen-2015-010310) (PMID:26936907) (PMCID:PMC4785328)

McCallum, J. E., Mackenzie, A. E., Divorty, N., Clarke, C., Delles, C. , Milligan, G. and Nicklin, S. A. (2016) G protein-coupled receptor 35 mediates human saphenous vein vascular smooth muscle cell migration and endothelial cell proliferation. Journal of Vascular Research, 52(6), pp. 383-395. (doi:10.1159/000444754) (PMID:27064272) (PMCID:PMC4959467)

Olsen, M. H. et al. (2016) A call to action and a lifecourse strategy to address the global burden of raised blood pressure on current and future generations: the Lancet Commission on hypertension. Lancet, 388(10060), pp. 2665-2712. (doi:10.1016/S0140-6736(16)31134-5) (PMID:27671667)

Sheikh, A. M., Small, H. Y., Currie, G. and Delles, C. (2016) Systematic review of micro-RNA expression in pre-eclampsia identifies a number of common pathways associated with the disease. PLoS ONE, 11(8), e0160808. (doi:10.1371/journal.pone.0160808) (PMID:27529341) (PMCID:PMC4986940)

Zhang, Z.-y. et al. (2016) Diastolic left ventricular function in relation to urinary and serum collagen biomarkers in a general population. PLoS ONE, 11(12), e0167582. (doi:10.1371/journal.pone.0167582) (PMID:27959898) (PMCID:PMC5154519)

2015

Akehurst, C. et al. (2015) Differential expression of microRNA-206 and its target genes in pre-eclampsia. Journal of Hypertension, 33(10), pp. 2068-2074. (doi:10.1097/HJH.0000000000000656) (PMID:26213997) (PMCID:PMC4570688)

Lindsey, M. L. et al. (2015) Transformative impact of proteomics on cardiovascular health and disease: a scientific statement from the American Heart Association. Circulation, 132(9), pp. 852-872. (doi:10.1161/CIR.0000000000000226) (PMID:26195497)

Schanstra, J.P. et al. (2015) Diagnosis and prediction of CKD progression by assessment of urinary peptides. Journal of the American Society of Nephrology, 26(8), pp. 1999-2010. (doi:10.1681/asn.2014050423) (PMID:25589610) (PMCID:PMC4520165)

Dakin, R. S., Parker, A. L., Delles, C. , Nicklin, S. A. and Baker, A. H. (2015) Efficient transduction of primary vascular cells by the rare adenovirus serotype 49 vector. Human Gene Therapy, 26(5), pp. 312-319. (doi:10.1089/hum.2015.019) (PMID:25760682) (PMCID:PMC4442572)

Fox, C. S. et al. (2015) Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association. Circulation, 131(19), pp. 1715-1736. (PMID:25882488) (PMCID:PMC4825323)

Ravassa, S., Kuznetsova, T., Varo, N., Thijs, L., Delles, C. , Dominiczak, A. , Díez, J. and Staessen, J. A. (2015) Biomarkers of cardiomyocyte injury and stress identify left atrial and left ventricular remodelling and dysfunction: a population-based study. International Journal of Cardiology, 185, pp. 177-185. (doi:10.1016/j.ijcard.2015.03.046) (PMID:25796005)

McInnes, I. B. et al. (2015) Effect of interleukin-6 receptor blockade on surrogates of vascular risk in rheumatoid arthritis: MEASURE, a randomised, placebo-controlled study. Annals of the Rheumatic Diseases, 74(4), pp. 694-702. (doi:10.1136/annrheumdis-2013-204345) (PMID:24368514) (PMCID:PMC4392313)

Mischak, H., Delles, C. , Vlahou, A. and Vanholder, R. (2015) Proteomic biomarkers in kidney disease: issues in development and implementation. Nature Reviews Nephrology, 11(4), pp. 221-232. (doi:10.1038/nrneph.2014.247) (PMID:25643662)

Brown, C. E. et al. (2015) Urinary proteomic biomarkers to predict cardiovascular events. Proteomics Clinical Applications, 9(5-6), pp. 610-617. (doi:10.1002/prca.201400195) (PMID:25786980)

Mistry, H.D., Eisele, N., Escher, G., Dick, B., Surbek, D., Delles, C. , Currie, G. , Schlembach, D., Mohaupt, M.G. and Gennari-Moser, C. (2015) Gestation-specific reference intervals for comprehensive spot urinary steroid hormone metabolite analysis in normal singleton pregnancy and 6 weeks postpartum. Reproductive Biology and Endocrinology, 13, 101. (doi:10.1186/s12958-015-0100-6) (PMID:26337185) (PMCID:PMC4559160)

Musunuru, K. et al. (2015) Basic concepts and potential applications of genetics and genomics for cardiovascular and stroke clinicians: a scientific statement from the American Heart Association. Circulation: Cardiovascular Genetics, 8(1), pp. 216-242. (doi:10.1161/HCG.0000000000000020) (PMID:25561044) (PMCID:PMC4887701)

2014

Currie, G. , McKay, G. and Delles, C. (2014) Biomarkers in diabetic nephropathy: present and future. World Journal of Diabetes, 5(6), pp. 763-776. 25512779. (doi:10.4239/wjd.v5.i6.763) (PMID:PMC4265863)

Herbert, A. et al. (2014) Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors. European Heart Journal, 35(44), pp. 3122-3133. (doi:10.1093/eurheartj/ehu293) (PMID:25112663)

Siwy, J. et al. (2014) Multicentre prospective validation of a urinary peptidome-based classifier for the diagnosis of type 2 diabetic nephropathy. Nephrology Dialysis Transplantation, 29(8), pp. 1563-1570. (doi:10.1093/ndt/gfu039)

Husi, H., Van Agtmael, T. , Mullen, W. , Bahlmann, F. H., Schanstra, J. P., Vlahou, A., Delles, C. , Perco, P. and Mischak, H. (2014) Proteome-based systems biology analysis of the diabetic mouse aorta reveals major changes in fatty acid biosynthesis as potential hallmark in diabetes mellitus-associated vascular disease. Circulation: Cardiovascular Genetics, 7(2), pp. 161-170. (doi:10.1161/CIRCGENETICS.113.000196)

Tragante, V. et al. (2014) Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. American Journal of Human Genetics, 94(3), pp. 349-360. (doi:10.1016/j.ajhg.2013.12.016)

Mark, P.B. , Boyle, S., Zimmerli, L.U., McQuarrie, E.P., Delles, C. and Freel, E.M. (2014) Alterations in vascular function in primary aldosteronism - a cardiovascular magnetic resonance imaging study. Journal of Human Hypertension, 28(2), pp. 92-97. (doi:10.1038/jhh.2013.70)

Carty, D.M., Neisius, U., Rooney, L.K., Dominiczak, A.F. and Delles, C. (2014) Pulse wave analysis for the prediction of preeclampsia. Journal of Human Hypertension, 28(2), pp. 98-104. (doi:10.1038/jhh.2013.64)

Klein, J., Buffin-Meyer, B., Mullen, W. , Carty, D. M., Delles, C. , Vlahou, A., Mischak, H., Decramer, S., Bascands, J.-L. and Schanstra, J. P. (2014) Clinical proteomics in obstetrics and neonatology. Expert Review of Proteomics, 11(1), pp. 75-89. (doi:10.1586/14789450.2014.872564)

Denby, L. et al. (2014) MicroRNA-214 antagonism protects against renal fibrosis. Journal of the American Society of Nephrology, 25(1), pp. 65-80. (doi:10.1681/ASN.2013010072)

Gillis, K.A. et al. (2014) Inter-study reproducibility of arterial spin labelling magnetic resonance imaging for measurement of renal perfusion in healthy volunteers at 3 Tesla. BMC Nephrology, 15(23), (doi:10.1186/1471-2369-15-23)

Gu, Y.-M. et al. (2014) The urinary proteome as correlate and predictor of renal function in a population study. Nephrology Dialysis Transplantation, 29(12), pp. 2260-2268. (doi:10.1093/ndt/gfu234)

Jacobs, L. et al. (2014) Heart 'omics' in AGEing (HOMAGE): design, research objectives and characteristics of the common database. Journal of Biomedical Research, 28(5), pp. 349-359. (doi:10.7555/JBR.28.20140045) (PMID:25332706) (PMCID:PMC4197385)

Nkuipou-Kenfack, E. et al. (2014) Assessment of metabolomic and proteomic biomarkers in detection and prognosis of progression of renal function in chronic kidney disease. PLoS ONE, 9(5), e96955. (doi:10.1371/journal.pone.0096955) (PMID:24817014) (PMCID:PMC4016198)

Persu, A. et al. (2014) Eligibility for renal denervation: experience at 11 European expert centers. Hypertension, 63(6), pp. 1319-25. (doi:10.1161/​HYPERTENSIONAHA.114.03194) (PMID:24664290)

2013

Rossi, S. H. et al. (2013) Impaired renal function impacts negatively on vascular stiffness in patients with coronary artery disease. BMC Nephrology, 14(173), (doi:10.1186/1471-2369-14-173)

Carty, D.M., Dominiczak, A. and Delles, C. (2013) Pulse wave analysis for prediction of preeclampsia. Endocrine Reviews, 34(3), SAT-520.

Delles, C. (2013) Homocysteine and the very elderly. Journal of Hypertension, 31(5), pp. 874-876. (doi:10.1097/HJH.0b013e328360aa8b)

Delles, C. and Freel, E.M. (2013) Aldosterone, vascular endothelial growth factor, and preeclampsia: a mystery solved? Hypertension, 61(5), pp. 958-960. (doi:10.1161/HYPERTENSIONAHA.111.00767)

Baker, A. H. and Delles, C. (2013) Is microRNA-376c a biomarker or mediator of preeclampsia? Hypertension, 61(4), pp. 767-769. (doi:10.1161/HYPERTENSIONAHA.111.00087)

MacKenzie, R.M. et al. (2013) Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes. Clinical Science, 124(6), pp. 403-411. (doi:10.1042/CS20120239)

Bryce, G.J., Payne, D.J., Gibson, S.C., Byrne, D.S., Delles, C. , McClure, J.D. and Kingsmore, D. (2013) B-type natriuretic peptide predicts postoperative cardiac events and mortality after elective open abdominal aortic aneurysm repair. Journal of Vascular Surgery, 57(2), pp. 345-353. (doi:10.1016/j.jvs.2012.07.053)

Guo, Y., Lanktree, M. B., Taylor, K. C., Hakonarson, H., Lange, L. A., Keating, B. J., Padmanabhan, S. , Delles, C. , Dominiczak, A. F. and Hastie, C. (2013) Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. Human Molecular Genetics, 22(1), pp. 184-201. (doi:10.1093/hmg/dds396) (PMID:23001569) (PMCID:PMC3522401)

Argiles, A. et al. (2013) CKD273, a new proteomics classifier assessing CKD and its prognosis. PLoS ONE, 8(5), e62837. (doi:10.1371/journal.pone.0062837) (PMID:23690958) (PMCID:PMC3653906)

Carty, D. M., Schiffer, E. and Delles, C. (2013) Proteomics in hypertension. Journal of Human Hypertension, 27(4), pp. 211-216. (doi:10.1038/jhh.2012.30) (PMID:22874797)

Currie, G. and Delles, C. (2013) Proteinuria and its relation to cardiovascular disease. International Journal of Nephrology and Renovascular Disease, 7, pp. 13-24. (doi:10.2147/IJNRD.S40522) (PMID:24379690) (PMCID:PMC3873205)

Husi, H., Sanchez-Niño, M., Delles, C. , Mullen, W. , Vlahou, A., Ortiz, A. and Mischak, H. (2013) A combinatorial approach of Proteomics and Systems Biology in unravelling the mechanisms of acute kidney injury (AKI): involvement of NMDA receptor GRIN1 in murine AKI. BMC Systems Biology, 7(110), (doi:10.1186/1752-0509-7-110)

White, K. M., Alba, R., Parker, A. L., Wright, A. F., Bradshaw, A. C. , Delles, C. , McDonald, R. A. and Baker, A. H. (2013) Assessment of a novel, capsid-modified adenovirus with an improved vascular gene transfer profile. Journal of Cardiothoracic Surgery, 8(183), (doi:10.1186/1749-8090-8-183)

2012

Chick, H.E. et al. (2012) Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk. Human Gene Therapy, 23(12), pp. 1247-1257. (doi:10.1089/hum.2012.042)

MacKenzie, R.M., Sandrim, V.C., Carty, D.M., McClure, J.D. , Freeman, D.J., Dominiczak, A.F. , McBride, M.W. and Delles, C. (2012) Endothelial FOS expression and pre-eclampsia. BJOG: An International Journal of Obstetrics and Gynaecology, 119(13), pp. 1564-1571. (doi:10.1111/1471-0528.12016)

Asselbergs, F.W. et al. (2012) Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. American Journal of Human Genetics, 91(5), pp. 823-838. (doi:10.1016/j.ajhg.2012.08.032)

Mischak, H. et al. (2012) Implementation of proteomic biomarkers: making it work. European Journal of Clinical Investigation, 42(9), pp. 1027-1036. (doi:10.1111/j.1365-2362.2012.02674.x) (PMID:22519700) (PMCID:PMC3464367)

Hocking, L.J. et al. (2012) Heritability of chronic pain in 2195 extended families. European Journal of Pain, 16(7), pp. 1053-1063. (doi:10.1002/j.1532-2149.2011.00095.x)

McInnes, I. , Lee, J.S., Thompson, L., Giles, J.T., Bathton, J.M., Salmon, J.E., Beaulieu, A.D., Codding, C.E., Delles, C. and Sattar, N. (2012) The effects of tocilizumab treatment on lipids and inflammatory/prothrombotic markers in patients (pts) with rheumatoid arthritis (RA): data from the randomized, controlled, measure study. European Heart Journal, 33(Sup 1), p. 281. (doi:10.1093/eurheartj/ehs281)

Bryce, G.J., Payne, C.J., Gibson, S.C., Kingsmore, D.B., Byrne, D.S. and Delles, C. (2012) Risk stratification scores in elective open abdominal aortic aneurysm repair: are they suitable for preoperative decision making? European Journal of Vascular and Endovascular Surgery, 44(1), pp. 55-61. (doi:10.1016/j.ejvs.2012.03.021)

Delles, C. , Neisius, U. and Carty, D.M. (2012) Proteomics in hypertension and other cardiovascular diseases. Annals of Medicine, 44(S1), S55-S64. (doi:10.3109/07853890.2012.660494)

Carty, D.M., Anderson, L.A., Freeman, D.J., Welsh, P.I. , Brennand, J.E., Dominiczak, A.F. and Delles, C. (2012) Early pregnancy soluble E-selectin concentrations and risk of preeclampsia. Journal of Hypertension, 30(5), pp. 954-959. (doi:10.1097/HJH.0b013e328352573b)

Kane, N. M. et al. (2012) Role of MicroRNAs 99b, 181a, and 181b in the differentiation of human embryonic stem cells to vascular endothelial cells. Stem Cells, 30(4), pp. 643-654. (doi:10.1002/stem.1026)

Carty, D.M., Anderson, L.A., Duncan, C.N., Baird, D., Rooney, L.K., Dominiczak, A.F. and Delles, C. (2012) Peripheral arterial tone: assessment of microcirculatory function in pregnancy. Journal of Hypertension, 30(1), pp. 117-123. (doi:10.1097/HJH.0b013e32834d76fb)

Dawson, J. , Walters, M. , Delles, C. , Mischak, H. and Mullen, W. (2012) Urinary proteomics to support diagnosis of stroke. PLoS ONE, 7(5), e35879. (doi:10.1371/journal.pone.0035879)

Delles, C. and Padmanabhan, S. (2012) Genetics and hypertension: is it time to change my practice? Canadian Journal of Cardiology, 28(3), pp. 296-304. (doi:10.1016/j.cjca.2012.02.004)

Neisius, U. et al. (2012) Association of central and peripheral pulse pressure with intermediate cardiovascular phenoytpes. Journal of Hypertension, 30(1), pp. 67-74. (doi:10.1097/HJH.0b013e32834e12d8)

Neisius, U., Schneider, M.P. and Delles, C. (2012) Association of central and peripheral pulse pressure with intermediate cardiovascular phenotypes Reply. Journal of Hypertension, 30(4), p. 835. (doi:10.1097/HJH.0b013e328350e57c)

2011

Johnson, T. et al. (2011) Blood pressure loci identified with a gene-centric array. American Journal of Human Genetics, 89(6), pp. 688-700. (doi:10.1016/j.ajhg.2011.10.013)

Delles, C. , Diez, J. and Dominiczak, A.F. (2011) Urinary proteomics in cardiovascular disease: achievements, limits and hopes. Proteomics Clinical Applications, 5(5-6), pp. 222-232. (doi:10.1002/prca.201000125)

Ott, C., Schneider, M.P., Delles, C. , Schlaich, M.P., Hilgers, K.F. and Schmieder, R.E. (2011) Association of (pro)renin receptor gene polymorphism with blood pressure in Caucasian men. Pharmacogenetics and Genomics, 21(6), pp. 347-349. (doi:10.1097/FPC.0b013e328344cdd2)

McQuarrie, E.P., Patel, R.K., Mark, P.B. , Delles, C. , Connell, J., Dargie, H.J., Steedman, T. and Jardine, A.G. (2011) Association between proteinuria and left ventricular mass index: a cardiac MRI study in patients with chronic kidney disease. Nephrology Dialysis Transplantation, 26(3), pp. 933-938. (doi:10.1093/ndt/gfq418)

Stevens, K.K., Morgan, I.R., Patel, R.K., Geddes, C.C., Mark, P.B. , Jardine, A.G. and Delles, C. (2011) Serum phosphate and outcome at one year after deceased donor renal transplantation. Clinical Transplantation, 25(2), E199-E204. (doi:10.1111/j.1399-0012.2011.01400.x)

Lanktree, M. B. et al. (2011) Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. American Journal of Human Genetics, 88(1), pp. 6-18. (doi:10.1016/j.ajhg.2010.11.007)

Carty, D.M. et al. (2011) Urinary proteomics for prediction of preeclampsia. Hypertension, 57(3), pp. 561-569. (doi:10.1161/HYPERTENSIONAHA.110.164285)

Mullen, W. , Delles, C. and Mischak, H. (2011) Urinary proteomics in the assessment of chronic kidney disease. Current Opinion in Nephrology and Hypertension, 20(6), pp. 654-661. (doi:10.1097/MNH.0b013e32834b7ffa)

Mullen, W. , Gonzalez, J., Siwy, J., Franke, J., Sattar, N. , Mullan, A., Roberts, S., Delles, C. , Mischak, H. and Albalat, A. (2011) A pilot study on the effect of short-term consumption of a polyphenol rich drink on biomarkers of coronary artery disease defined by urinary proteomics. Journal of Agricultural and Food Chemistry, 59(24), pp. 12850-12857. (doi:10.1021/jf203369r) (PMID:22070129)

Ott, C., Schneider, M. P., Delles, C. , Schlaich, M. P. and Schmieder, R. E. (2011) Reduction in Basal Nitric Oxide Activity Causes Albuminuria. Diabetes, 60(2), pp. 572-576. (doi:10.2337/db09-1630)

2010

Good, D. M. et al. (2010) Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease. Molecular and Cellular Proteomics, 9(11), pp. 2424-2437. (doi:10.1074/mcp.M110.001917)

Carty, D.M., Delles, C. and Dominiczak, A.F. (2010) Preeclampsia and future maternal health. Journal of Hypertension, 28(7), pp. 1349-1355. (doi:10.1097/HJH.0b013e32833a39d0)

Delles, C. (2010) Angiotensinogen, birth weight and diabetes: will genetics provide a link? Journal of Hypertension, 28(4), pp. 665-667. (doi:10.1097/HJH.0b013e328337f524 Univ Glasgow, BHF Glasgow Cardiovasc Res Ctr, Glasgow G12 8TA, Lanark, Scotland.)

Delles, C. , Dymott, J.A., Neisius, U., Rocchiccioli, J.P., Bryce, G.J., Moreno Zulategui, M.U., Carty, D.M., Berg, G.A., Hamilton, C.A. and Dominiczak, A.F. (2010) Reduced LDL-cholesterol levels in patients with coronary artery disease are paralelled by improved endothelial function: An observational study in patients from 2003 and 2007. Atherosclerosis, 211(1), pp. 271-277. (doi:10.1016/j.atherosclerosis.2010.01.014)

Delles, C. and Jardine, A.G. (2010) Renal function and cardiovascular events: relevance of eGFR and albuminuria in patients with diabetes. Diabetologia, 54(1), pp. 4-6. (doi:10.1007/s00125-010-1942-2)

Delles, C. , McBride, M.W. , Graham, D. , Padmanabhan, S. and Dominiczak, A.F. (2010) Genetics of hypertension: from experimental animals to humans. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1802(12), pp. 1299-1308. (doi:10.1016/j.bbadis.2009.12.006)

Delles, C. et al. (2010) Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 individuals. Journal of Hypertension, 28(11), pp. 2316-2322. (doi:10.1097/HJH.0b013e32833d81b7)

Dominiczak, A. F. et al. (2010) Systems biology to battle vascular disease. Nephrology Dialysis Transplantation, 25(4), pp. 1019-1022. (doi:10.1093/ndt/gfq025)

Maahs, D.M. et al. (2010) Urinary collagen fragments are significantly altered in diabetes: a link to pathophysiology. PLoS ONE, 5(9), e13051. (doi:10.1371/journal.pone.0013051)

Mischak, H., Delles, C. , Klein, J. and Schanstra, J.P. (2010) Urinary Proteomics Based on Capillary Electrophoresis-Coupled Mass Spectrometry in Kidney Disease: Discovery and Validation of Biomarkers, and Clinical Application. Advances in Chronic Kidney Disease, 17(6), pp. 493-506. (doi:10.1053/j.ackd.2010.09.004)

Padmanabhan, S. et al. (2010) Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genetics, 6(10), e1001177. (doi:10.1371/journal.pgen.1001177)

Padmanabhan, S. et al. (2010) The effects of sex and method of blood pressure measurement on genetic associations with blood pressure in the PAMELA study. Journal of Hypertension, 28(3), pp. 465-477. (doi:10.1097/HJH.0b013e32833594d7)

Taurino, C., Miller, W.H., McBride, M.W. , McClure, J.D. , Khanin, R., Moreno Zulategui, M.U., Dymott, J., Delles, C. and Dominiczak, A.F. (2010) Gene expression profiling in whole blood of patients with coronary artery disease. Clinical Science, 119(8), pp. 335-343. (doi:10.1042/CS20100043)

2009

Talmud, P. et al. (2009) Gene-centric association signals for lipids and apolipoproteins identified via the humanCVD BeadChip. American Journal of Human Genetics, 85(5), pp. 628-642. (doi:10.1016/j.ajhg.2009.10.014)

Dominiczak, A. F. , Delles, C. and Padmanabhan, S. (2009) Are isolated populations better for studying genes that predispose to hypertension? Journal of Hypertension, 27(5), pp. 939-940. (doi:10.1097/HJH.0b013e328329fca3) (PMCID:PMC2709222)

2008

Delles, C. (2008) Risk factors and target organ damage: is there a special case for prehypertension? Journal of Hypertension, 26(12), pp. 2268-2270. (doi:10.1097/HJH.0b013e328317f039)

Delles, C. , McBride, M.W. , Padmanabhan, S. and Dominiczak, A.F. (2008) The genetics of cardiovascular disease. Trends in Endocrinology and Metabolism, 19(9), pp. 309-316. (doi:10.1016/j.tem.2008.07.010)

Delles, C. , Raff, U., Mimran, A., Fauvel, J.P., Ruilope, L.M. and Schmieder, R.E. (2008) Effects of telmisartan and ramipril on adiponectin and blood pressure in patients with type 2 diabetes. American Journal of Hypertension, 21(12), pp. 1330-1336. (doi:10.1038/ajh.2008.297)

Jantos-Siwy, J., Schiffer, E., Brand, K., Schumann, G., Rossing, K., Delles, C. , Mischak, H. and Metzger, J. (2008) Quantitative urinary proteome analysis for biomarker evaluation in chronic kidney disease. Journal of Proteome Research, 8(1), pp. 268-281. (doi:10.1021/pr800401m) (PMID:19012428)

Ritt, M., Ott, C., Delles, C. , Schneider, M.P. and Schmieder, R.E. (2008) Impact of the endothelial nitric oxide synthase gene G894T polymorphism on renal endothelial function in patients with type 2 diabetes. Pharmacogenetics and Genomics, 18(8), pp. 699-707.

Delles, C. et al. (2008) Glutathione S-transferase variants and hypertension. Journal of Hypertension, 26(7), pp. 1343-1352. (doi:10.1097/HJH.0b013e3282fe1d67)

Padmanabhan, S. , Melander, O., Hastie, C., Menni, C., Delles, C. , Connell, J. M. and Dominiczak, A. F. (2008) Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols. Journal of Hypertension, 26(7), pp. 1275-1281. (doi:10.1097/HJH.0b013e3282ff634f)

Delles, C. , Zimmerli, L., McGrane, D. J., Koh-Tan, C. H.H., Pathi, V. L., McKay, A. J., Steedman, T., Dargie, H. J., Hamilton, C. A. and Dominiczak, A. F. (2008) Vascular stiffness is related to superoxide generation in the vessel wall. Journal of Hypertension, 26(5), pp. 946-955.

Berry, C. , Zimmerli, L.U., Steedman, T., Foster, J.E., Dargie, H.J., Berg, H.A., Dominiczak, A.F. and Delles, C. (2008) Cardiac magnetic resonance findings predict increased resource utilization in elective coronary artery bypass grafting. Clinical Science, 114(6), pp. 423-430. (doi:10.1042/CS20070337)

Zimmerli, L.U. et al. (2008) Urinary proteomic biomarkers on coronary artery disease. Molecular and Cellular Proteomics, 7(2), pp. 290-298. (doi:10.1074/mcp.M700394-MCP200)

Carty, D., Delles, C. and Dominiczak, A. (2008) Novel Biomarkers for Predicting Preeclampsia. Trends in Cardiovascular Medicine, 18(5), pp. 186-194. (doi:10.1016/j.tcm.2008.07.002)

Delles, C. (2008) Candidate gene studies in cardiovascular medicine: complex diseases and even more complex intermediate phenotypes. Journal of Hypertension, 26(6), pp. 1069-1071.

Delles, C. , Miller, W. H. and Dominiczak, A. F. (2008) Targeting reactive oxygen species in hypertension. Antioxidants and Redox Signaling, 10(6), pp. 1061-1077. (doi:10.1089/ars.2007.2008)

Dymott, J.A., Chow, C., Rocchiccioli, J.P., Berg, G.A., Cherry, A.K.L., Delles, C. , Hamilton, C.A. and Dominiczak, A.F. (2008) Endothelial function in patients undergoing coronary artery by-pass grafting is improved in patients in 2006 compared to 2003. Scottish Medical Journal, 53(1), p. 57.

Schneider, M. P., Delles, C. , Klingbeil, A. U., Ludwig, M., Kolloch, R. E., Krekler, M., Stumpe, K. O. and Schmieder, R. E. (2008) Effect of angiotensin receptor blockade on central haemodynamics in essential hypertension: results of a randomised trial. Journal of the Renin-Angiotensin-Aldosterone System, 9(1), pp. 49-56. (doi:10.3317/jraas.2008.003) (PMID:18404609)

2007

Delles, C. (2007) Mitochondria, maternal transmission and hypertension. Journal of Hypertension, 25(10), pp. 2001-2003. (doi:10.1097/HJH.0b013e3282ef6cfa)

Delles, C. (2007) Vascular function in rheumatoid arthritis: intermediate phenotypes and cardiovascular risk. Journal of Hypertension, 25(6), pp. 1195-1196. (doi:10.1097/HJH.0b013e3280dd8a77)

Schlaich, M.P., Oehmer, S., Schneider, M.P., Delles, C. , Schmidt, B.M.W. and Schmieder, R.E. (2007) Effects of nitric oxide synthase inhibition and L-arginine on renal haemodynamics in young patients at high cardiovascular risk. Atherosclerosis, 192(1), pp. 155-160. (doi:10.1016/j.atherosclerosis.2006.04.025)

Schmieder, R., Delles, C. , Mimran, A., Fauvel, J. and Ruilope, L. (2007) Impact of telmisartan versus ramipri on ronal endothelial function in patients with hypertension and type 2 diabetes. Diabetes Care, 30(6), pp. 1351-1356. (doi:10.2337/dc06-1551)

Zimmerli, L., Mark, P. , Steedman, T., Foster, J., Berg, G., Dargie, H., Jardine, A. , Delles, C. and Dominiczak, A. (2007) Vascular function in patients with end-stage renal disease and/or coronary artery disease: A cardiac magnetic resonance imaging study. Kidney International, 71(1), pp. 68-73. (doi:10.1038/sj.ki.5002024)

2006

Al Benna, S., Hamilton, C.A., McClure, J.D. , Rogers, P.N., Berg, G.A., Ford, I. , Delles, C. and Dominiczak, A.F. (2006) Low-density lipoprotein cholesterol determines oxidative stress and endothelial dysfunction in saphenous veins from patients with coronary artery disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(1), pp. 218-223. (doi:10.1161/01.ATV.0000193626.22269.45)

Delles, C. and Dominiczak, A. (2006) Vascular failure or sick vessel syndrome: The cardiovascular continuum is a useful concept for clinical research. Journal of Hypertension, 24(11), pp. 2147-2148. (doi:10.1097/01.hjh.0000249687.43123.d2)

McBride, M. , Graham, D., Delles, C. and Dominiczak, A. (2006) Functional genomics in hypertension. Current Opinion in Nephrology and Hypertension, 15(2), pp. 145-151. (doi:10.1097/01.mnh.0000203188.57513.3f)

Michelson, G., Warntges, S., Harazny, J., Oehmer, S., Delles, C. and Schmieder, R.E. (2006) Effect of NOS inhibition on retinal arterial and capillary circulation in early arterial hypertension. Retina: The Journal of Retinal and Vitreous Diseases, 26(4), pp. 437-444. (doi:10.1097/01.iae.0000238550.74626.e5)

Oehmer, S., Harazny, J., Delles, C. , Schwarz, T., Handrock, R., Michelson, G. and Schmieder, R. (2006) Valsartan and retinal endothelial function in elderly hypertensive patients. Blood Pressure, 15(3), pp. 185-191. (doi:10.1080/08037050600772680)

Schaufele, T., Schlaich, M., Delles, C. , Klingbeil, A., Fleischmann, E. and Schmieder, R. (2006) Impaired basal NO activity in patients with glomerular disease and the influence of oxidative stress. Kidney International, 70(6), pp. 1177-1181. (doi:10.1038/sj.ki.5001745)

Schmidt, B., Sammer, U., Fleischmann, I., Schlaich, M., Delles, C. and Schmieder, R. (2006) Rapid nongenomic effects of aldosterone on the renal vasculature in humans. Hypertension, 47(4), pp. 650-655. (doi:10.1161/01.HYP.0000205224.58715.cc)

2005

Schneider, M.P., Delles, C. , Schmidt, B.M.W., Oehmer, S., Schwarz, T.K., Schmieder, R.E. and John, S. (2005) Superoxide scavenging effects of N-acetylcysteine and vitamin C in subjects with essential hypertension. American Journal of Hypertension, 18(8), pp. 1111-1117. (doi:10.1016/j.amjhyper.2005.02.006)

John, S., Schneider, M.P., Delles, C. , Jacobi, J. and Schmieder, R.E. (2005) Lipid-independent effects of statins on endothelial function and bioavailability of nitric oxide in hypercholesterolemic patients. American Heart Journal, 149(3), 473.e1-473.e10. (doi:10.1016/j.ahj.2004.06.02)

Dominiczak, A. F. , Graham, D. , McBride, M. W. , Brain, N. J.R., Lee, W. K., Charchar, F. J., Tomaszewski, M., Delles, C. and Hamilton, C. A. (2005) Corcoran Lecture. Cardiovascular genomics and oxidative stress. Hypertension, 45(4), pp. 636-642. (doi:10.1161/01.HYP.0000154253.53134.09)

Schmieder, R., Klingbeil, A., Fleischmann, E., Veelken, R. and Delles, C. (2005) Additional antiproteinuric effect of ultrahigh dose candesartan: A double-blind, randomized, prospective study. Journal of the American Society of Nephrology, 16(10), pp. 3038-3045. (doi:10.1681/ASN.2005020138)

2004

Delles, C. , Klingbeil, A.U., Schneider, M.P., Handrock, R., Schaufele, T. and Schmieder, R.E. (2004) The role of nitric oxide in the regulation of glomerular haemodynamics in humans. Nephrology Dialysis Transplantation, 19(6), pp. 1392-1397. (doi:10.1093/ndt/gfh187)

Delles, C. , Schluter, C., Wittmann, M., Renders, L., Riess, R., Rosch, W., Schott, G., Rupprecht, H. and Kunzendorf, U. (2004) "Very delayed" graft function in a patient after living related kidney transplantation: A case report. Transplantation Proceedings, 36, pp. 1377-1379. (doi:10.1016/j.transproceed.2004.05.015)

Delles, C. , Schluter, C., Wittmann, M., Renders, L., Riess, R., Rosch, W., Schott, G., Rupprecht, H. and Kunzendorf, U. (2004) 'Very delayed' graft function in a patient after living related kidney transplantation: A case report. Transplantation Proceedings, 36(5), pp. 1377-1379. (doi:10.1016/j.transproceed.2004.05.015)

Delles, C. and Schmieder, R. (2004) Effects of the angiotensin-1 receptor blocker valsartan compared with amlodipine on renal hemodynamics - Reply. American Journal of Hypertension, 17(7), pp. 639-640.

Delles, C. and Schmieder, R. (2004) Is the afferent arteriole the main location of nitric oxide action and synthesis in humans? Reply. Nephrology Dialysis Transplantation, 19(11), pp. 2925-2926.

Delles, C. and Schmieder, R. (2004) Renal endothelial effects of anti hypertensive therapy. Current Opinion in Nephrology and Hypertension, 13(5), pp. 489-493.

Delles, C. , Michelson, G., Harazny, J., Oehmer, S., Hilgers, K.F. and Schmieder, R.E. (2004) Impaired endothelial function of the retinal vasculature in hypertensive patients. Stroke, 35(6), pp. 1289-1293. (doi:10.1161/01.STR.0000126597.11534.3b)

Delles, C. , Schneider, M., Oehmer, S., Fleischmann, I., Fleischmann, E.F. and Schmeider, R.E. (2004) Increased response of renal perfusion to the antioxidant vitamin C in type 2 diabetes. Nephrology Dialysis Transplantation, 19(10), pp. 2513-2518. (doi:10.1093/ndt/gfh405)

Fleischmann, E.H., John, S., Delles, C. , Schneider, M.P., Schmidt, B.M.W. and Schmieder, R.E. (2004) The effect of statins on angiotensin II-induced hemodynamic changes in young, mildly hypercholesterolemic men. American Journal of Hypertension, 17(12), pp. 1120-1126. (doi:10.1016/j.amjhyper.2004.07.011)

Schneider, M.P., Klingbeil, A.U., Delles, C. , Ludwig, M., Kolloch, R.E., Krekler, M., Stumpe, K.O. and Schmieder, R.E. (2004) Effect of irbesartan versus atenolol on left ventricular mass and voltage: results of the Cardio Vascular Irbesartan Project. Hypertension, 44(1), pp. 61-66. (doi:10.1161/01.HYP.0000133249.28773.d7)

2003

Delles, C. , Klingbeil, A.U., Schneider, M.P., Handrock, R., Schmieder, R.E. and Weidinger, G. (2003) Direct comparison of the effects of valsartan and amlodipine on renal hemodynamics in human essential hypertension. American Journal of Hypertension, 16(12), pp. 1030-1035. (doi:10.1016/j.amjhyper.2003.07.017)

Schneider, M.P., Klingbeil, A.U., Delles, C. , Schmidt, B.M.W., John, S. and Schmieder, R.E. (2003) Vitamin C augments the renal response to L-arginine in smokers. Nephrology Dialysis Transplantation, 18(8), pp. 1512-1517. (doi:10.1093/ndt/gfg195)

Delles, C. , Schneider, M.P., Oehmer, S., Fleischmann, E.H. and Schmieder, R.E. (2003) L-arginine-induced vasodilation of the renal vasculature is not altered in hypertensive patients with type 2 diabetes. Diabetes Care, 26(6), pp. 1836-1840. (doi:10.2337/diacare.26.6.1836)

Schneider, M.P., Delles, C. , Fleischmann, E., Schmidt, B.M.W., John, S. and Schmieder, R.E. (2003) Effect of elevated triglyceride levels on endothelium-dependent vasodilation in patients with hypercholesterolemia. American Journal of Cardiology, 91(4), pp. 482-484. (doi:10.1016/S0002-9149(02)03255-1)

Delles, C. , Schmidt, B., Muller, H., Oehmer, S., Klingbeil, A. and Schmieder, R. (2003) Functional relevance of aldosterone for the determination of left ventricular mass. American Journal of Cardiology, 91(3), pp. 297-301. (doi:10.1016/S0002-9149(02)03158-2)

Delles, C. and Schmieder, R. (2003) Endothelial function of the human renal vasculature. Deutsche Medizinische Wochenschrift, 128(3), pp. 92-96.

Schmidt, B.M.W., Oehmer, S., Delles, C. , Bratke, R., Schneider, M.P., Klingbeil, A., Fleischmann, E.H. and Schmieder, R.E. (2003) Rapid nongenomic effects of aldosterone on human forearm vasculature. Hypertension, 42(2), pp. 156-160. (doi:10.1161/​01.HYP.0000083298.23119.16)

Schneider, M.P., Hilgers, K.F., Huang, Y., Delles, C. , John, S., Oehmer, S. and Schmieder, R.E. (2003) The C242T p22phox polymorphism and endothelium-dependent vasodilation in subjects with hypercholesterolaemia. Clinical Science, 105(1), pp. 97-103. (doi:10.1042/CS20030003)

2002

Schlaich, M.P., Klingbeil, A.U., Jacobi, J., Delles, C. , Schneider, M.P., Schmidt, B.M. and Schmieder, R.E. (2002) Altered aldosterone response to salt intake and angiotensin II infusion in young normotensive men with parental history of arterial hypertension. Journal of Hypertension, 20(1), pp. 117-24.

Delles, C. , Jacobi, J., John, S., Fleischmann, I. and Schmieder, R. (2002) Effects of enalapril and eprosartan on the renal vascular nitric oxide system in human essential hypertension. Kidney International, 61(4), pp. 1462-1468. (doi:10.1046/j.1523-1755.2002.00260.x)

Delles, C. , Jacobi, J., Schlaich, M., John, S. and Schmieder, R. (2002) Assessment of endothelial function of the renal vasculature in human subjects. American Journal of Hypertension, 15(1), pp. 3-9. (doi:10.1016/S0895-7061(01)02242-7)

Delles, C. , Schneider, M., John, S., Gekle, M. and Schmieder, R. (2002) Angiotensin converting enzyme inhibition and angiotensin II AT(1)-receptor blockade reduce the levels of asymmetrical N-G, N-G-dimethylarginine in human essential hypertension. American Journal of Hypertension, 15(7), pp. 590-593. (doi:10.1016/S0895-7061(02)02278-1)

Delles, C. , Weidner, S., Schobel, H. and Rupprecht, H. (2002) Renal-artery stenosis in a patient with Takayasu's arteritis. Nephrology Dialysis Transplantation, 17(7), pp. 1339-1341. (doi:10.1093/ndt/17.7.1339)

Delles, C. , Wittmann, M., Renders, L., Kunzendorf, U., Bohner, C., Wutke, R., Lang, W., Schott, G. and Rupprecht, H. (2002) Restoration of renal allograft function by endovascular stenting of an iliac artery dissection. Nephrology Dialysis Transplantation, 17(6), pp. 1116-1118. (doi:10.1093/ndt/17.6.1116)

2001

Zeltner, R., Delles, C. , Schneider, M., Siffert, W. and Schmieder, R.E. (2001) G-protein beta(3) subunit gene (GNB3) 825T allele is associated with enhanced renal perfusion in early hypertension. Hypertension, 37(3), pp. 882-886. (doi:10.1161/​01.HYP.37.3.882)

Delles, C. , Erdmann, J., Jacobi, J., Hilgers, K., Fleck, E., Regitz-Zagrosek, V. and Schmieder, R. (2001) Aldosterone synthase (CYP11B2)-344 C/T polymorphism is associated with left ventricular structure in human arterial hypertension. Journal of the American College of Cardiology, 37(3), pp. 878-884. (doi:10.1016/S0735-1097(00)01174-8)

Delles, C. and Schmieder, R. (2001) The kidney in congestive heart failure: Renal adverse event rate of treatment. Journal of Cardiovascular Pharmacology, 38(1), pp. 99-107.

Hilgers, K., Delles, C. , Veelken, R. and Schmieder, R. (2001) Angiotensinogen gene core promoter variants and non-modulating hypertension. Hypertension, 38(6), pp. 1250-1254. (doi:10.1161/hy1201.096545)

John, S., Delles, C. , Jacobi, J., Schlaich, M.P., Schneider, M., Schmitz, G. and Schmieder, R.E. (2001) Rapid improvement of nitric oxide bioavailability after lipid-lowering therapy with cerivastatin within two weeks. Journal of the American College of Cardiology, 37(5), pp. 1351-1358. (doi:10.1016/S0735-1097(01)01128-7)

Leidig, M., Delles, C. , Kuchenbecker, C., Lederle, X., Weidinger, G. and Schmieder, R. (2001) Pharmacokinetics of valsartan in hypertensive patients on long-term haemodialysis. Clinical Drug Investigation, 21(1), pp. 59-66. (doi:10.2165/00044011-200121010-00008)

Schmieder, R., Erdmann, J., Delles, C. , Jacobi, J., Fleck, E., Hilgers, K. and Regitz-Zagrosek, V. (2001) Effect of the angiotensin II type 2-receptor gene (+1675 G/A) on left ventricular structure in humans. Journal of the American College of Cardiology, 37(1), pp. 175-182. (doi:10.1016/S0735-1097(00)01063-9)

Schneider, M., Erdmann, J., Delles, C. , Fleck, E., Regitz-Zagrosek, V. and Schmieder, R. (2001) Functional gene testing of the Glu298Asp polymorphism of the endothelial nitric oxide synthase - Reply. Journal of Hypertension, 19(7), pp. 1341-1342.

Veelken, R., Delles, C. , Hilgers, K. and Schmieder, R. (2001) Outcome survey in unselected hypertensive patients with type 2 diabetes mellitus: effects of ACE inhibition. American Journal of Hypertension, 14(7), pp. 672-678. (doi:10.1016/S0895-7061(01)01300-0)

This list was generated on Mon Dec 17 10:21:56 2018 GMT.
Number of items: 199.

Articles

Lucas-Herald, A. K., Zürbig, P., Mason, A., Kinning, E., Brown, C., Mansoorian, B., Mullen, W. , Ahmed, S. F. and Delles, C. (2018) Proteomic evidence of biological ageing in a child with a compound heterozygous ZMPSTE24 mutation. Proteomics Clinical Applications, (Accepted for Publication)

Rossitto, G., Touyz, R. M. , Petrie, M. C. and Delles, C. (2018) Much ado about N…atrium: modelling tissue sodium as a highly sensitive marker of subclinical and localised oedema. Clinical Science, (Accepted for Publication)

Sliz, E. et al. (2018) Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment. Circulation, 138(22), pp. 2499-2512. (PMID:30524137)

Dayan, N., Schlosser, K., Stewart, D. J., Delles, C. , Kaur, A. and Pilote, L. (2018) Circulating microRNAs implicate multiple atherogenic abnormalities in the long-term cardiovascular sequelae of preeclampsia. American Journal of Hypertension, 31(10), pp. 1093-1097. (doi:10.1093/ajh/hpy069) (PMID:29800045) (PMCID:PMC6132124)

Tofte, N. et al. (2018) Characteristics of high- and low-risk individuals in the PRIORITY study: urinary proteomics and mineralocorticoid receptor antagonism for prevention of diabetic nephropathy in Type 2 diabetes. Diabetic Medicine, 35(10), pp. 1375-1382. (doi:10.1111/dme.13669) (PMID:29781558)

Ravassa, S. et al. (2018) Biomarker-based phenotyping of myocardial fibrosis identifies patients with heart failure with preserved ejection fraction resistant to the beneficial effects of spironolactone: results from the Aldo-DHF trial. European Journal of Heart Failure, 20(9), pp. 1290-1299. (doi:10.1002/ejhf.1194) (PMID:29709099)

Gillis, K., Stevens, K. K., Bell, E., Patel, R. K., Jardine, A. G. , Morris, S. T.W., Schneider, M. P., Delles, C. and Mark, P. B. (2018) Ascorbic acid lowers central blood pressure and asymmetric dimethylarginine in chronic kidney disease. Clinical Kidney Journal, 11(4), pp. 532-539. (doi:10.1093/ckj/sfx158) (PMID:30094018) (PMCID:PMC6070083)

Kerr, D. M.I., Brooksbank, K. J.M., Taylor, R. G., Pinel, K., Rios, F. J., Touyz, R. M. and Delles, C. (2018) Acute effects of electronic and tobacco cigarettes on vascular and respiratory function in healthy volunteers: a cross-over study. Journal of Hypertension, (doi:10.1097/HJH.0000000000001890) (PMID:30063637) (Early Online Publication)

Moreton, F. C., Cullen, B. , Delles, C. , Santosh, C., Lopez Gonzalez, R., Dani, K. and Muir, K. W. (2018) Vasoreactivity in CADASIL: comparison to structural MRI and neuropsychology. Journal of Cerebral Blood Flow and Metabolism, 38(6), pp. 1085-1095. (doi:10.1177/0271678X17710375) (PMID:28537106)

Lygirou, V., Latosinska, A., Makridakis, M., Mullen, W. , Delles, C. , Schanstra, J. P., Zoidakis, J., Pieske, B., Mischak, H. and Vlahou, A. (2018) Plasma proteomic analysis reveals altered protein abundances in cardiovascular disease. Journal of Translational Medicine, 16(1), 104. (doi:10.1186/s12967-018-1476-9) (PMID:29665821) (PMCID:PMC5905170)

Currie, G. E. et al. (2018) Urinary proteomics for prediction of mortality in patients with type 2 diabetes and microalbuminuria. Cardiovascular Diabetology, 17, 50. (doi:10.1186/s12933-018-0697-9) (PMID:29625564)

Delles, C. and Currie, G. (2018) Sex differences in hypertension and other cardiovascular diseases. Journal of Hypertension, 36(4), pp. 768-770. (doi:10.1097/HJH.0000000000001655) (PMID:29489615)

Delles, C. et al. (2018) Nuclear magnetic resonance-based metabolomics identifies phenylalanine as a novel predictor of incident heart failure hospitalisation: results from PROSPER and FINRISK 1997. European Journal of Heart Failure, 20, pp. 663-673. (doi:10.1002/ejhf.1076) (PMID:29226610)

Feng, Y.-M. et al. (2018) Glomerular function in relation to circulating adhesion molecules and inflammation markers in a general population. Nephrology Dialysis Transplantation, 33(3), pp. 426-435. (doi:10.1093/ndt/gfx256) (PMID:28992257)

Currie, G. and Delles, C. (2018) Blood pressure targets in the elderly. Journal of Hypertension, 36(2), pp. 234-236. (doi:10.1097/HJH.0000000000001576)

Krochmal, M. et al. (2017) Urinary peptidomics analysis reveals proteases involved in diabetic nephropathy. Scientific Reports, 7, 15160. (doi:10.1038/s41598-017-15359-9) (PMID:29123184) (PMCID:PMC5680307)

Pontillo, C. et al. (2017) Prediction of chronic kidney disease stage 3 by CKD273, a urinary proteomic biomarker. Kidney International Reports, 2(6), pp. 1066-1075. (doi:10.1016/j.ekir.2017.06.004) (PMID:29130072) (PMCID:PMC5669285)

Schmieder, R. E. et al. (2017) The effect of sacubitril/valsartan compared to olmesartan on cardiovascular remodelling in subjects with essential hypertension: the results of a randomized, double-blind, active-controlled study. European Heart Journal, 38(44), pp. 3308-3317. (doi:10.1093/eurheartj/ehx525) (PMID:29029087)

Stevens, K., Denby, L., Patel, R. K., Mark, P. B. , Kettlewell, S., Smith, G. L. , Clancy, M. J., Delles, C. and Jardine, A. G. (2017) Deleterious effects of phosphate on vascular and endothelial function via disruption to the nitric oxide pathway. Nephrology Dialysis Transplantation, 32(10), pp. 1617-1627. (doi:10.1093/ndt/gfw252) (PMID:27448672)

Krochmal, M. et al. (2017) Identification of novel molecular signatures of IgA nephropathy through an integrative -omics analysis. Scientific Reports, 7(1), 9091. (doi:10.1038/s41598-017-09393-w) (PMID:28831120) (PMCID:PMC5567309)

Currie, G. and Delles, C. (2017) Healthy vascular aging. Hypertension, 70(2), pp. 229-231. (doi:10.1161/HYPERTENSIONAHA.117.09122) (PMID:28559393)

Gajjala, P. R. et al. (2017) Proteomic-biostatistic integrated approach for finding the underlying molecular determinants of hypertension in human plasma. Hypertension, 70, pp. 412-419. (doi:10.1161/HYPERTENSIONAHA.116.08906) (PMID:28652472)

Small, H. Y., Cornelius, D. C., Guzik, T. J. and Delles, C. (2017) Natural killer cells in placentation and cancer: Implications for hypertension during pregnancy. Placenta, 56, pp. 59-64. (doi:10.1016/j.placenta.2017.03.003) (PMID:28318556)

Zhang, Z.‐Y. et al. (2017) Novel urinary peptidomic classifier predicts incident heart failure. Journal of the American Heart Association, 6(8), e005432. (doi:10.1161/JAHA.116.005432) (PMID:28784649) (PMCID:PMC5586413)

Knez, J. et al. (2017) Peripheral blood mitochondrial DNA content in relation to circulating metabolites and inflammatory markers: a population study. PLoS ONE, 12(7), e0181036. (doi:10.1371/journal.pone.0181036) (PMID:28704533) (PMCID:PMC5509283)

Neisius, U., Olson, E., Rossi, S. H., Ibrahim, H. A., Currie, G. , Dominiczak, A. and Delles, C. (2017) Evaluation of the systemic micro- and macrovasculature in stable angina: a case-control study. PLoS ONE, 12(5), e0178412. (doi:10.1371/journal.pone.0178412) (PMID:28542516) (PMCID:PMC5444845)

Jacobs, L. et al. (2017) Risk for incident heart failure: a subject-level meta-analysis from the Heart “OMics” in AGEing (HOMAGE) study. Journal of the American Heart Association, 6(5), e005231. (doi:10.1161/JAHA.116.005231) (PMID:28465299)

Mary, S., Small, H. Y., Siwy, J., Mullen, W. , Giri, A. and Delles, C. (2017) Polymerization-incompetent uromodulin in the pregnant stroke-prone spontaneously hypertensive rat. Hypertension, 69(5), pp. 910-918. (doi:10.1161/HYPERTENSIONAHA.116.08826) (PMID:28348009) (PMCID:PMC5389592)

Dominiczak, A. , Delles, C. and Padmanabhan, S. (2017) Genomics and precision medicine for clinicians and scientists in hypertension. Hypertension, 69(4), e10-e13. (doi:10.1161/HYPERTENSIONAHA.116.08252) (PMID:28193712)

Htun, N. M. et al. (2017) Prediction of acute coronary syndromes by urinary proteome analysis. PLoS ONE, 12(3), e0172036.. (doi:10.1371/journal.pone.0172036) (PMID:28273075) (PMCID:PMC5342174)

Carty, D. M., Doogan, F., Welsh, P. , Dominiczak, A. F. and Delles, C. (2017) Thyroid stimulating hormone (TSH) ≥2.5mU/l in early pregnancy: prevalence and subsequent outcomes. European Journal of Obstetrics and Gynecology and Reproductive Biology, 210, pp. 366-369. (doi:10.1016/j.ejogrb.2017.01.048) (PMID:28153744)

Currie, G. and Delles, C. (2017) The future of "omics" in hypertension. Canadian Journal of Cardiology, 33(5), pp. 601-610. (doi:10.1016/j.cjca.2016.11.023) (PMID:28161100) (PMCID:5417769)

Small, H. Y., Akehurst, C., Sharafetdinova, L., McBride, M. W. , McClure, J. D. , Robinson, S. W., Carty, D. M., Freeman, D. J. and Delles, C. (2017) HLA gene expression is altered in whole blood and placenta from women who later developed preeclampsia. Physiological Genomics, 49(3), pp. 193-200. (doi:10.1152/physiolgenomics.00106.2016) (PMID:28130428) (PMCID:PMC5374453)

Delles, C. and Vanholder, R. (2017) Chronic kidney disease. Clinical Science, 131(3), pp. 225-226. (doi:10.1042/CS20160624) (PMID:28057893)

Ferreira, J. P. et al. (2016) Renal function estimation and Cockroft–Gault formulas for predicting cardiovascular mortality in population-based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: the Heart ‘OMics’ in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives. BMC Medicine, 14, 181. (doi:10.1186/s12916-016-0731-2) (PMID:27829460) (PMCID:PMC5103492)

Rutherford, C. et al. (2016) Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling. Science Signaling, 9(453), ra109. (doi:10.1126/scisignal.aaf8566) (PMID:27919027)

Currie, G. and Delles, C. (2016) Urinary proteomics for diagnosis and monitoring of diabetic nephropathy. Current Diabetes Reports, 16(11), 104. (doi:10.1007/s11892-016-0798-3) (PMID:27658932)

Small, H. Y., Nosalski, R., Morgan, H., Beattie, E., Guzik, T., Graham, D. and Delles, C. (2016) The role of tumor necrosis factor-α and natural killer cells in uterine artery function and pregnancy outcome in the stroke prone spontaneously hypertensive rat. Hypertension, 68(5), pp. 1298-1307. (doi:10.1161/HYPERTENSIONAHA.116.07933) (PMID:27733586) (PMCID:PMC5058643)

Currie, G. et al. (2016) Effect of mineralocorticoid receptor antagonists on proteinuria and progression of chronic kidney disease: a systematic review and meta-analysis. BMC Nephrology, 17, 127. (doi:10.1186/s12882-016-0337-0) (PMID:27609359) (PMCID:PMC5015203)

Mordi, I., Mordi, N., Delles, C. and Tzemos, N. (2016) Endothelial dysfunction in human essential hypertension. Journal of Hypertension, 34(8), pp. 1464-1472. (doi:10.1097/hjh.0000000000000965) (PMID:27203578)

Currie, G. and Delles, C. (2016) Use of biomarkers in the evaluation and treatment of hypertensive patients. Current Hypertension Reports, 18(7), 54. (doi:10.1007/s11906-016-0661-6) (PMID:27221728)

Wan Sulaiman, W.N., Caslake, M.J., Delles, C. , Karlsson, H., Mulder, M.T., Graham, D. and Freeman, D.J. (2016) Does high-density lipoprotein protect vascular function in healthy pregnancy? Clinical Science, 130(7), pp. 491-497. (doi:10.1042/cs20150475) (PMID:26888561)

Eisele, N. et al. (2016) Placental expression of the angiogenic placental growth factor is stimulated by both aldosterone and simulated starvation. Placenta, 40, pp. 18-24. (doi:10.1016/j.placenta.2016.02.004) (PMID:27016778)

Neisius, U. et al. (2016) Urine proteomics in the diagnosis of stable angina. BMC Cardiovascular Disorders, 16, 70. (doi:10.1186/s12872-016-0246-y) (PMID:27095611) (PMCID:PMC483761)

Mullan, A., Delles, C. , Ferrell, W., Mullen, W. , Edwards, C. A. , McColl, J. H. , Roberts, S. A. and Lean, M. (2016) Effects of a beverage rich in (poly)phenols on established and novel risk markers for vascular disease in medically uncomplicated overweight or obese subjects: A four week randomized trial. Atherosclerosis, 246, pp. 169-176. (doi:10.1016/j.atherosclerosis.2016.01.004) (PMID:26797134)

Currie, G. , Delles, C. , Touyz, R. M. , Staessen, J. A., Dominiczak, A. F. , Jennings, G. L. R. and Wang, J.-G. (2016) A woman with treatment-resistant hypertension. Hypertension, 67(2), pp. 243-250. (doi:10.1161/HYPERTENSIONAHA.115.06756) (PMID:26711735)

Small, H. Y., Currie, G. E. and Delles, C. (2016) Prostasin, proteases, and preeclampsia. Journal of Hypertension, 34(2), pp. 193-195. (doi:10.1097/hjh.0000000000000828) (PMID:26682786)

Small, H. Y., Morgan, H., Beattie, E., Griffin, S., Indahl, M., Delles, C. and Graham, D. (2016) Abnormal uterine artery remodelling in the stroke prone spontaneously hypertensive rat. Placenta, 37, pp. 34-44. (doi:10.1016/j.placenta.2015.10.022) (PMID:26612342) (PMCID:PMC4721537)

Gillis, K. A., Mccomb, C., Patel, R. K., Stevens, K. K., Schneider, M. P., Radjenovic, A. , Morris, S. T.W., Roditi, G. H., Delles, C. and Mark, P. B. (2016) Non-contrast renal magnetic resonance imaging to assess perfusion and corticomedullary differentiation in health and chronic kidney disease. Nephron, 133(3), pp. 183-192. (doi:10.1159/000447601) (PMID:27362585)

Lindhardt, M. et al. (2016) Proteomic prediction and Renin angiotensin aldosterone system Inhibition prevention Of early diabetic nephRopathy in TYpe 2 diabetic patients with normoalbuminuria (PRIORITY): essential study design and rationale of a randomised clinical multicentre trial. BMJ Open, 6(3), e010310. (doi:10.1136/bmjopen-2015-010310) (PMID:26936907) (PMCID:PMC4785328)

McCallum, J. E., Mackenzie, A. E., Divorty, N., Clarke, C., Delles, C. , Milligan, G. and Nicklin, S. A. (2016) G protein-coupled receptor 35 mediates human saphenous vein vascular smooth muscle cell migration and endothelial cell proliferation. Journal of Vascular Research, 52(6), pp. 383-395. (doi:10.1159/000444754) (PMID:27064272) (PMCID:PMC4959467)

Olsen, M. H. et al. (2016) A call to action and a lifecourse strategy to address the global burden of raised blood pressure on current and future generations: the Lancet Commission on hypertension. Lancet, 388(10060), pp. 2665-2712. (doi:10.1016/S0140-6736(16)31134-5) (PMID:27671667)

Sheikh, A. M., Small, H. Y., Currie, G. and Delles, C. (2016) Systematic review of micro-RNA expression in pre-eclampsia identifies a number of common pathways associated with the disease. PLoS ONE, 11(8), e0160808. (doi:10.1371/journal.pone.0160808) (PMID:27529341) (PMCID:PMC4986940)

Zhang, Z.-y. et al. (2016) Diastolic left ventricular function in relation to urinary and serum collagen biomarkers in a general population. PLoS ONE, 11(12), e0167582. (doi:10.1371/journal.pone.0167582) (PMID:27959898) (PMCID:PMC5154519)

Akehurst, C. et al. (2015) Differential expression of microRNA-206 and its target genes in pre-eclampsia. Journal of Hypertension, 33(10), pp. 2068-2074. (doi:10.1097/HJH.0000000000000656) (PMID:26213997) (PMCID:PMC4570688)

Lindsey, M. L. et al. (2015) Transformative impact of proteomics on cardiovascular health and disease: a scientific statement from the American Heart Association. Circulation, 132(9), pp. 852-872. (doi:10.1161/CIR.0000000000000226) (PMID:26195497)

Schanstra, J.P. et al. (2015) Diagnosis and prediction of CKD progression by assessment of urinary peptides. Journal of the American Society of Nephrology, 26(8), pp. 1999-2010. (doi:10.1681/asn.2014050423) (PMID:25589610) (PMCID:PMC4520165)

Dakin, R. S., Parker, A. L., Delles, C. , Nicklin, S. A. and Baker, A. H. (2015) Efficient transduction of primary vascular cells by the rare adenovirus serotype 49 vector. Human Gene Therapy, 26(5), pp. 312-319. (doi:10.1089/hum.2015.019) (PMID:25760682) (PMCID:PMC4442572)

Fox, C. S. et al. (2015) Future translational applications from the contemporary genomics era: a scientific statement from the American Heart Association. Circulation, 131(19), pp. 1715-1736. (PMID:25882488) (PMCID:PMC4825323)

Ravassa, S., Kuznetsova, T., Varo, N., Thijs, L., Delles, C. , Dominiczak, A. , Díez, J. and Staessen, J. A. (2015) Biomarkers of cardiomyocyte injury and stress identify left atrial and left ventricular remodelling and dysfunction: a population-based study. International Journal of Cardiology, 185, pp. 177-185. (doi:10.1016/j.ijcard.2015.03.046) (PMID:25796005)

McInnes, I. B. et al. (2015) Effect of interleukin-6 receptor blockade on surrogates of vascular risk in rheumatoid arthritis: MEASURE, a randomised, placebo-controlled study. Annals of the Rheumatic Diseases, 74(4), pp. 694-702. (doi:10.1136/annrheumdis-2013-204345) (PMID:24368514) (PMCID:PMC4392313)

Mischak, H., Delles, C. , Vlahou, A. and Vanholder, R. (2015) Proteomic biomarkers in kidney disease: issues in development and implementation. Nature Reviews Nephrology, 11(4), pp. 221-232. (doi:10.1038/nrneph.2014.247) (PMID:25643662)

Brown, C. E. et al. (2015) Urinary proteomic biomarkers to predict cardiovascular events. Proteomics Clinical Applications, 9(5-6), pp. 610-617. (doi:10.1002/prca.201400195) (PMID:25786980)

Mistry, H.D., Eisele, N., Escher, G., Dick, B., Surbek, D., Delles, C. , Currie, G. , Schlembach, D., Mohaupt, M.G. and Gennari-Moser, C. (2015) Gestation-specific reference intervals for comprehensive spot urinary steroid hormone metabolite analysis in normal singleton pregnancy and 6 weeks postpartum. Reproductive Biology and Endocrinology, 13, 101. (doi:10.1186/s12958-015-0100-6) (PMID:26337185) (PMCID:PMC4559160)

Musunuru, K. et al. (2015) Basic concepts and potential applications of genetics and genomics for cardiovascular and stroke clinicians: a scientific statement from the American Heart Association. Circulation: Cardiovascular Genetics, 8(1), pp. 216-242. (doi:10.1161/HCG.0000000000000020) (PMID:25561044) (PMCID:PMC4887701)

Currie, G. , McKay, G. and Delles, C. (2014) Biomarkers in diabetic nephropathy: present and future. World Journal of Diabetes, 5(6), pp. 763-776. 25512779. (doi:10.4239/wjd.v5.i6.763) (PMID:PMC4265863)

Herbert, A. et al. (2014) Establishing reference values for central blood pressure and its amplification in a general healthy population and according to cardiovascular risk factors. European Heart Journal, 35(44), pp. 3122-3133. (doi:10.1093/eurheartj/ehu293) (PMID:25112663)

Siwy, J. et al. (2014) Multicentre prospective validation of a urinary peptidome-based classifier for the diagnosis of type 2 diabetic nephropathy. Nephrology Dialysis Transplantation, 29(8), pp. 1563-1570. (doi:10.1093/ndt/gfu039)

Husi, H., Van Agtmael, T. , Mullen, W. , Bahlmann, F. H., Schanstra, J. P., Vlahou, A., Delles, C. , Perco, P. and Mischak, H. (2014) Proteome-based systems biology analysis of the diabetic mouse aorta reveals major changes in fatty acid biosynthesis as potential hallmark in diabetes mellitus-associated vascular disease. Circulation: Cardiovascular Genetics, 7(2), pp. 161-170. (doi:10.1161/CIRCGENETICS.113.000196)

Tragante, V. et al. (2014) Gene-centric meta-analysis in 87,736 individuals of European ancestry identifies multiple blood-pressure-related loci. American Journal of Human Genetics, 94(3), pp. 349-360. (doi:10.1016/j.ajhg.2013.12.016)

Mark, P.B. , Boyle, S., Zimmerli, L.U., McQuarrie, E.P., Delles, C. and Freel, E.M. (2014) Alterations in vascular function in primary aldosteronism - a cardiovascular magnetic resonance imaging study. Journal of Human Hypertension, 28(2), pp. 92-97. (doi:10.1038/jhh.2013.70)

Carty, D.M., Neisius, U., Rooney, L.K., Dominiczak, A.F. and Delles, C. (2014) Pulse wave analysis for the prediction of preeclampsia. Journal of Human Hypertension, 28(2), pp. 98-104. (doi:10.1038/jhh.2013.64)

Klein, J., Buffin-Meyer, B., Mullen, W. , Carty, D. M., Delles, C. , Vlahou, A., Mischak, H., Decramer, S., Bascands, J.-L. and Schanstra, J. P. (2014) Clinical proteomics in obstetrics and neonatology. Expert Review of Proteomics, 11(1), pp. 75-89. (doi:10.1586/14789450.2014.872564)

Denby, L. et al. (2014) MicroRNA-214 antagonism protects against renal fibrosis. Journal of the American Society of Nephrology, 25(1), pp. 65-80. (doi:10.1681/ASN.2013010072)

Gillis, K.A. et al. (2014) Inter-study reproducibility of arterial spin labelling magnetic resonance imaging for measurement of renal perfusion in healthy volunteers at 3 Tesla. BMC Nephrology, 15(23), (doi:10.1186/1471-2369-15-23)

Gu, Y.-M. et al. (2014) The urinary proteome as correlate and predictor of renal function in a population study. Nephrology Dialysis Transplantation, 29(12), pp. 2260-2268. (doi:10.1093/ndt/gfu234)

Jacobs, L. et al. (2014) Heart 'omics' in AGEing (HOMAGE): design, research objectives and characteristics of the common database. Journal of Biomedical Research, 28(5), pp. 349-359. (doi:10.7555/JBR.28.20140045) (PMID:25332706) (PMCID:PMC4197385)

Nkuipou-Kenfack, E. et al. (2014) Assessment of metabolomic and proteomic biomarkers in detection and prognosis of progression of renal function in chronic kidney disease. PLoS ONE, 9(5), e96955. (doi:10.1371/journal.pone.0096955) (PMID:24817014) (PMCID:PMC4016198)

Persu, A. et al. (2014) Eligibility for renal denervation: experience at 11 European expert centers. Hypertension, 63(6), pp. 1319-25. (doi:10.1161/​HYPERTENSIONAHA.114.03194) (PMID:24664290)

Rossi, S. H. et al. (2013) Impaired renal function impacts negatively on vascular stiffness in patients with coronary artery disease. BMC Nephrology, 14(173), (doi:10.1186/1471-2369-14-173)

Carty, D.M., Dominiczak, A. and Delles, C. (2013) Pulse wave analysis for prediction of preeclampsia. Endocrine Reviews, 34(3), SAT-520.

Delles, C. (2013) Homocysteine and the very elderly. Journal of Hypertension, 31(5), pp. 874-876. (doi:10.1097/HJH.0b013e328360aa8b)

Delles, C. and Freel, E.M. (2013) Aldosterone, vascular endothelial growth factor, and preeclampsia: a mystery solved? Hypertension, 61(5), pp. 958-960. (doi:10.1161/HYPERTENSIONAHA.111.00767)

Baker, A. H. and Delles, C. (2013) Is microRNA-376c a biomarker or mediator of preeclampsia? Hypertension, 61(4), pp. 767-769. (doi:10.1161/HYPERTENSIONAHA.111.00087)

MacKenzie, R.M. et al. (2013) Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes. Clinical Science, 124(6), pp. 403-411. (doi:10.1042/CS20120239)

Bryce, G.J., Payne, D.J., Gibson, S.C., Byrne, D.S., Delles, C. , McClure, J.D. and Kingsmore, D. (2013) B-type natriuretic peptide predicts postoperative cardiac events and mortality after elective open abdominal aortic aneurysm repair. Journal of Vascular Surgery, 57(2), pp. 345-353. (doi:10.1016/j.jvs.2012.07.053)

Guo, Y., Lanktree, M. B., Taylor, K. C., Hakonarson, H., Lange, L. A., Keating, B. J., Padmanabhan, S. , Delles, C. , Dominiczak, A. F. and Hastie, C. (2013) Gene-centric meta-analyses of 108 912 individuals confirm known body mass index loci and reveal three novel signals. Human Molecular Genetics, 22(1), pp. 184-201. (doi:10.1093/hmg/dds396) (PMID:23001569) (PMCID:PMC3522401)

Argiles, A. et al. (2013) CKD273, a new proteomics classifier assessing CKD and its prognosis. PLoS ONE, 8(5), e62837. (doi:10.1371/journal.pone.0062837) (PMID:23690958) (PMCID:PMC3653906)

Carty, D. M., Schiffer, E. and Delles, C. (2013) Proteomics in hypertension. Journal of Human Hypertension, 27(4), pp. 211-216. (doi:10.1038/jhh.2012.30) (PMID:22874797)

Currie, G. and Delles, C. (2013) Proteinuria and its relation to cardiovascular disease. International Journal of Nephrology and Renovascular Disease, 7, pp. 13-24. (doi:10.2147/IJNRD.S40522) (PMID:24379690) (PMCID:PMC3873205)

Husi, H., Sanchez-Niño, M., Delles, C. , Mullen, W. , Vlahou, A., Ortiz, A. and Mischak, H. (2013) A combinatorial approach of Proteomics and Systems Biology in unravelling the mechanisms of acute kidney injury (AKI): involvement of NMDA receptor GRIN1 in murine AKI. BMC Systems Biology, 7(110), (doi:10.1186/1752-0509-7-110)

White, K. M., Alba, R., Parker, A. L., Wright, A. F., Bradshaw, A. C. , Delles, C. , McDonald, R. A. and Baker, A. H. (2013) Assessment of a novel, capsid-modified adenovirus with an improved vascular gene transfer profile. Journal of Cardiothoracic Surgery, 8(183), (doi:10.1186/1749-8090-8-183)

Chick, H.E. et al. (2012) Integrase-deficient lentiviral vectors mediate efficient gene transfer to human vascular smooth muscle cells with minimal genotoxic risk. Human Gene Therapy, 23(12), pp. 1247-1257. (doi:10.1089/hum.2012.042)

MacKenzie, R.M., Sandrim, V.C., Carty, D.M., McClure, J.D. , Freeman, D.J., Dominiczak, A.F. , McBride, M.W. and Delles, C. (2012) Endothelial FOS expression and pre-eclampsia. BJOG: An International Journal of Obstetrics and Gynaecology, 119(13), pp. 1564-1571. (doi:10.1111/1471-0528.12016)

Asselbergs, F.W. et al. (2012) Large-scale gene-centric meta-analysis across 32 studies identifies multiple lipid loci. American Journal of Human Genetics, 91(5), pp. 823-838. (doi:10.1016/j.ajhg.2012.08.032)

Mischak, H. et al. (2012) Implementation of proteomic biomarkers: making it work. European Journal of Clinical Investigation, 42(9), pp. 1027-1036. (doi:10.1111/j.1365-2362.2012.02674.x) (PMID:22519700) (PMCID:PMC3464367)

Hocking, L.J. et al. (2012) Heritability of chronic pain in 2195 extended families. European Journal of Pain, 16(7), pp. 1053-1063. (doi:10.1002/j.1532-2149.2011.00095.x)

McInnes, I. , Lee, J.S., Thompson, L., Giles, J.T., Bathton, J.M., Salmon, J.E., Beaulieu, A.D., Codding, C.E., Delles, C. and Sattar, N. (2012) The effects of tocilizumab treatment on lipids and inflammatory/prothrombotic markers in patients (pts) with rheumatoid arthritis (RA): data from the randomized, controlled, measure study. European Heart Journal, 33(Sup 1), p. 281. (doi:10.1093/eurheartj/ehs281)

Bryce, G.J., Payne, C.J., Gibson, S.C., Kingsmore, D.B., Byrne, D.S. and Delles, C. (2012) Risk stratification scores in elective open abdominal aortic aneurysm repair: are they suitable for preoperative decision making? European Journal of Vascular and Endovascular Surgery, 44(1), pp. 55-61. (doi:10.1016/j.ejvs.2012.03.021)

Delles, C. , Neisius, U. and Carty, D.M. (2012) Proteomics in hypertension and other cardiovascular diseases. Annals of Medicine, 44(S1), S55-S64. (doi:10.3109/07853890.2012.660494)

Carty, D.M., Anderson, L.A., Freeman, D.J., Welsh, P.I. , Brennand, J.E., Dominiczak, A.F. and Delles, C. (2012) Early pregnancy soluble E-selectin concentrations and risk of preeclampsia. Journal of Hypertension, 30(5), pp. 954-959. (doi:10.1097/HJH.0b013e328352573b)

Kane, N. M. et al. (2012) Role of MicroRNAs 99b, 181a, and 181b in the differentiation of human embryonic stem cells to vascular endothelial cells. Stem Cells, 30(4), pp. 643-654. (doi:10.1002/stem.1026)

Carty, D.M., Anderson, L.A., Duncan, C.N., Baird, D., Rooney, L.K., Dominiczak, A.F. and Delles, C. (2012) Peripheral arterial tone: assessment of microcirculatory function in pregnancy. Journal of Hypertension, 30(1), pp. 117-123. (doi:10.1097/HJH.0b013e32834d76fb)

Dawson, J. , Walters, M. , Delles, C. , Mischak, H. and Mullen, W. (2012) Urinary proteomics to support diagnosis of stroke. PLoS ONE, 7(5), e35879. (doi:10.1371/journal.pone.0035879)

Delles, C. and Padmanabhan, S. (2012) Genetics and hypertension: is it time to change my practice? Canadian Journal of Cardiology, 28(3), pp. 296-304. (doi:10.1016/j.cjca.2012.02.004)

Neisius, U. et al. (2012) Association of central and peripheral pulse pressure with intermediate cardiovascular phenoytpes. Journal of Hypertension, 30(1), pp. 67-74. (doi:10.1097/HJH.0b013e32834e12d8)

Neisius, U., Schneider, M.P. and Delles, C. (2012) Association of central and peripheral pulse pressure with intermediate cardiovascular phenotypes Reply. Journal of Hypertension, 30(4), p. 835. (doi:10.1097/HJH.0b013e328350e57c)

Johnson, T. et al. (2011) Blood pressure loci identified with a gene-centric array. American Journal of Human Genetics, 89(6), pp. 688-700. (doi:10.1016/j.ajhg.2011.10.013)

Delles, C. , Diez, J. and Dominiczak, A.F. (2011) Urinary proteomics in cardiovascular disease: achievements, limits and hopes. Proteomics Clinical Applications, 5(5-6), pp. 222-232. (doi:10.1002/prca.201000125)

Ott, C., Schneider, M.P., Delles, C. , Schlaich, M.P., Hilgers, K.F. and Schmieder, R.E. (2011) Association of (pro)renin receptor gene polymorphism with blood pressure in Caucasian men. Pharmacogenetics and Genomics, 21(6), pp. 347-349. (doi:10.1097/FPC.0b013e328344cdd2)

McQuarrie, E.P., Patel, R.K., Mark, P.B. , Delles, C. , Connell, J., Dargie, H.J., Steedman, T. and Jardine, A.G. (2011) Association between proteinuria and left ventricular mass index: a cardiac MRI study in patients with chronic kidney disease. Nephrology Dialysis Transplantation, 26(3), pp. 933-938. (doi:10.1093/ndt/gfq418)

Stevens, K.K., Morgan, I.R., Patel, R.K., Geddes, C.C., Mark, P.B. , Jardine, A.G. and Delles, C. (2011) Serum phosphate and outcome at one year after deceased donor renal transplantation. Clinical Transplantation, 25(2), E199-E204. (doi:10.1111/j.1399-0012.2011.01400.x)

Lanktree, M. B. et al. (2011) Meta-analysis of Dense Genecentric Association Studies Reveals Common and Uncommon Variants Associated with Height. American Journal of Human Genetics, 88(1), pp. 6-18. (doi:10.1016/j.ajhg.2010.11.007)

Carty, D.M. et al. (2011) Urinary proteomics for prediction of preeclampsia. Hypertension, 57(3), pp. 561-569. (doi:10.1161/HYPERTENSIONAHA.110.164285)

Mullen, W. , Delles, C. and Mischak, H. (2011) Urinary proteomics in the assessment of chronic kidney disease. Current Opinion in Nephrology and Hypertension, 20(6), pp. 654-661. (doi:10.1097/MNH.0b013e32834b7ffa)

Mullen, W. , Gonzalez, J., Siwy, J., Franke, J., Sattar, N. , Mullan, A., Roberts, S., Delles, C. , Mischak, H. and Albalat, A. (2011) A pilot study on the effect of short-term consumption of a polyphenol rich drink on biomarkers of coronary artery disease defined by urinary proteomics. Journal of Agricultural and Food Chemistry, 59(24), pp. 12850-12857. (doi:10.1021/jf203369r) (PMID:22070129)

Ott, C., Schneider, M. P., Delles, C. , Schlaich, M. P. and Schmieder, R. E. (2011) Reduction in Basal Nitric Oxide Activity Causes Albuminuria. Diabetes, 60(2), pp. 572-576. (doi:10.2337/db09-1630)

Good, D. M. et al. (2010) Naturally Occurring Human Urinary Peptides for Use in Diagnosis of Chronic Kidney Disease. Molecular and Cellular Proteomics, 9(11), pp. 2424-2437. (doi:10.1074/mcp.M110.001917)

Carty, D.M., Delles, C. and Dominiczak, A.F. (2010) Preeclampsia and future maternal health. Journal of Hypertension, 28(7), pp. 1349-1355. (doi:10.1097/HJH.0b013e32833a39d0)

Delles, C. (2010) Angiotensinogen, birth weight and diabetes: will genetics provide a link? Journal of Hypertension, 28(4), pp. 665-667. (doi:10.1097/HJH.0b013e328337f524 Univ Glasgow, BHF Glasgow Cardiovasc Res Ctr, Glasgow G12 8TA, Lanark, Scotland.)

Delles, C. , Dymott, J.A., Neisius, U., Rocchiccioli, J.P., Bryce, G.J., Moreno Zulategui, M.U., Carty, D.M., Berg, G.A., Hamilton, C.A. and Dominiczak, A.F. (2010) Reduced LDL-cholesterol levels in patients with coronary artery disease are paralelled by improved endothelial function: An observational study in patients from 2003 and 2007. Atherosclerosis, 211(1), pp. 271-277. (doi:10.1016/j.atherosclerosis.2010.01.014)

Delles, C. and Jardine, A.G. (2010) Renal function and cardiovascular events: relevance of eGFR and albuminuria in patients with diabetes. Diabetologia, 54(1), pp. 4-6. (doi:10.1007/s00125-010-1942-2)

Delles, C. , McBride, M.W. , Graham, D. , Padmanabhan, S. and Dominiczak, A.F. (2010) Genetics of hypertension: from experimental animals to humans. Biochimica et Biophysica Acta: Molecular Basis of Disease, 1802(12), pp. 1299-1308. (doi:10.1016/j.bbadis.2009.12.006)

Delles, C. et al. (2010) Urinary proteomic diagnosis of coronary artery disease: identification and clinical validation in 623 individuals. Journal of Hypertension, 28(11), pp. 2316-2322. (doi:10.1097/HJH.0b013e32833d81b7)

Dominiczak, A. F. et al. (2010) Systems biology to battle vascular disease. Nephrology Dialysis Transplantation, 25(4), pp. 1019-1022. (doi:10.1093/ndt/gfq025)

Maahs, D.M. et al. (2010) Urinary collagen fragments are significantly altered in diabetes: a link to pathophysiology. PLoS ONE, 5(9), e13051. (doi:10.1371/journal.pone.0013051)

Mischak, H., Delles, C. , Klein, J. and Schanstra, J.P. (2010) Urinary Proteomics Based on Capillary Electrophoresis-Coupled Mass Spectrometry in Kidney Disease: Discovery and Validation of Biomarkers, and Clinical Application. Advances in Chronic Kidney Disease, 17(6), pp. 493-506. (doi:10.1053/j.ackd.2010.09.004)

Padmanabhan, S. et al. (2010) Genome-wide association study of blood pressure extremes identifies variant near UMOD associated with hypertension. PLoS Genetics, 6(10), e1001177. (doi:10.1371/journal.pgen.1001177)

Padmanabhan, S. et al. (2010) The effects of sex and method of blood pressure measurement on genetic associations with blood pressure in the PAMELA study. Journal of Hypertension, 28(3), pp. 465-477. (doi:10.1097/HJH.0b013e32833594d7)

Taurino, C., Miller, W.H., McBride, M.W. , McClure, J.D. , Khanin, R., Moreno Zulategui, M.U., Dymott, J., Delles, C. and Dominiczak, A.F. (2010) Gene expression profiling in whole blood of patients with coronary artery disease. Clinical Science, 119(8), pp. 335-343. (doi:10.1042/CS20100043)

Talmud, P. et al. (2009) Gene-centric association signals for lipids and apolipoproteins identified via the humanCVD BeadChip. American Journal of Human Genetics, 85(5), pp. 628-642. (doi:10.1016/j.ajhg.2009.10.014)

Dominiczak, A. F. , Delles, C. and Padmanabhan, S. (2009) Are isolated populations better for studying genes that predispose to hypertension? Journal of Hypertension, 27(5), pp. 939-940. (doi:10.1097/HJH.0b013e328329fca3) (PMCID:PMC2709222)

Delles, C. (2008) Risk factors and target organ damage: is there a special case for prehypertension? Journal of Hypertension, 26(12), pp. 2268-2270. (doi:10.1097/HJH.0b013e328317f039)

Delles, C. , McBride, M.W. , Padmanabhan, S. and Dominiczak, A.F. (2008) The genetics of cardiovascular disease. Trends in Endocrinology and Metabolism, 19(9), pp. 309-316. (doi:10.1016/j.tem.2008.07.010)

Delles, C. , Raff, U., Mimran, A., Fauvel, J.P., Ruilope, L.M. and Schmieder, R.E. (2008) Effects of telmisartan and ramipril on adiponectin and blood pressure in patients with type 2 diabetes. American Journal of Hypertension, 21(12), pp. 1330-1336. (doi:10.1038/ajh.2008.297)

Jantos-Siwy, J., Schiffer, E., Brand, K., Schumann, G., Rossing, K., Delles, C. , Mischak, H. and Metzger, J. (2008) Quantitative urinary proteome analysis for biomarker evaluation in chronic kidney disease. Journal of Proteome Research, 8(1), pp. 268-281. (doi:10.1021/pr800401m) (PMID:19012428)

Ritt, M., Ott, C., Delles, C. , Schneider, M.P. and Schmieder, R.E. (2008) Impact of the endothelial nitric oxide synthase gene G894T polymorphism on renal endothelial function in patients with type 2 diabetes. Pharmacogenetics and Genomics, 18(8), pp. 699-707.

Delles, C. et al. (2008) Glutathione S-transferase variants and hypertension. Journal of Hypertension, 26(7), pp. 1343-1352. (doi:10.1097/HJH.0b013e3282fe1d67)

Padmanabhan, S. , Melander, O., Hastie, C., Menni, C., Delles, C. , Connell, J. M. and Dominiczak, A. F. (2008) Hypertension and genome-wide association studies: combining high fidelity phenotyping and hypercontrols. Journal of Hypertension, 26(7), pp. 1275-1281. (doi:10.1097/HJH.0b013e3282ff634f)

Delles, C. , Zimmerli, L., McGrane, D. J., Koh-Tan, C. H.H., Pathi, V. L., McKay, A. J., Steedman, T., Dargie, H. J., Hamilton, C. A. and Dominiczak, A. F. (2008) Vascular stiffness is related to superoxide generation in the vessel wall. Journal of Hypertension, 26(5), pp. 946-955.

Berry, C. , Zimmerli, L.U., Steedman, T., Foster, J.E., Dargie, H.J., Berg, H.A., Dominiczak, A.F. and Delles, C. (2008) Cardiac magnetic resonance findings predict increased resource utilization in elective coronary artery bypass grafting. Clinical Science, 114(6), pp. 423-430. (doi:10.1042/CS20070337)

Zimmerli, L.U. et al. (2008) Urinary proteomic biomarkers on coronary artery disease. Molecular and Cellular Proteomics, 7(2), pp. 290-298. (doi:10.1074/mcp.M700394-MCP200)

Carty, D., Delles, C. and Dominiczak, A. (2008) Novel Biomarkers for Predicting Preeclampsia. Trends in Cardiovascular Medicine, 18(5), pp. 186-194. (doi:10.1016/j.tcm.2008.07.002)

Delles, C. (2008) Candidate gene studies in cardiovascular medicine: complex diseases and even more complex intermediate phenotypes. Journal of Hypertension, 26(6), pp. 1069-1071.

Delles, C. , Miller, W. H. and Dominiczak, A. F. (2008) Targeting reactive oxygen species in hypertension. Antioxidants and Redox Signaling, 10(6), pp. 1061-1077. (doi:10.1089/ars.2007.2008)

Dymott, J.A., Chow, C., Rocchiccioli, J.P., Berg, G.A., Cherry, A.K.L., Delles, C. , Hamilton, C.A. and Dominiczak, A.F. (2008) Endothelial function in patients undergoing coronary artery by-pass grafting is improved in patients in 2006 compared to 2003. Scottish Medical Journal, 53(1), p. 57.

Schneider, M. P., Delles, C. , Klingbeil, A. U., Ludwig, M., Kolloch, R. E., Krekler, M., Stumpe, K. O. and Schmieder, R. E. (2008) Effect of angiotensin receptor blockade on central haemodynamics in essential hypertension: results of a randomised trial. Journal of the Renin-Angiotensin-Aldosterone System, 9(1), pp. 49-56. (doi:10.3317/jraas.2008.003) (PMID:18404609)

Delles, C. (2007) Mitochondria, maternal transmission and hypertension. Journal of Hypertension, 25(10), pp. 2001-2003. (doi:10.1097/HJH.0b013e3282ef6cfa)

Delles, C. (2007) Vascular function in rheumatoid arthritis: intermediate phenotypes and cardiovascular risk. Journal of Hypertension, 25(6), pp. 1195-1196. (doi:10.1097/HJH.0b013e3280dd8a77)

Schlaich, M.P., Oehmer, S., Schneider, M.P., Delles, C. , Schmidt, B.M.W. and Schmieder, R.E. (2007) Effects of nitric oxide synthase inhibition and L-arginine on renal haemodynamics in young patients at high cardiovascular risk. Atherosclerosis, 192(1), pp. 155-160. (doi:10.1016/j.atherosclerosis.2006.04.025)

Schmieder, R., Delles, C. , Mimran, A., Fauvel, J. and Ruilope, L. (2007) Impact of telmisartan versus ramipri on ronal endothelial function in patients with hypertension and type 2 diabetes. Diabetes Care, 30(6), pp. 1351-1356. (doi:10.2337/dc06-1551)

Zimmerli, L., Mark, P. , Steedman, T., Foster, J., Berg, G., Dargie, H., Jardine, A. , Delles, C. and Dominiczak, A. (2007) Vascular function in patients with end-stage renal disease and/or coronary artery disease: A cardiac magnetic resonance imaging study. Kidney International, 71(1), pp. 68-73. (doi:10.1038/sj.ki.5002024)

Al Benna, S., Hamilton, C.A., McClure, J.D. , Rogers, P.N., Berg, G.A., Ford, I. , Delles, C. and Dominiczak, A.F. (2006) Low-density lipoprotein cholesterol determines oxidative stress and endothelial dysfunction in saphenous veins from patients with coronary artery disease. Arteriosclerosis, Thrombosis, and Vascular Biology, 26(1), pp. 218-223. (doi:10.1161/01.ATV.0000193626.22269.45)

Delles, C. and Dominiczak, A. (2006) Vascular failure or sick vessel syndrome: The cardiovascular continuum is a useful concept for clinical research. Journal of Hypertension, 24(11), pp. 2147-2148. (doi:10.1097/01.hjh.0000249687.43123.d2)

McBride, M. , Graham, D., Delles, C. and Dominiczak, A. (2006) Functional genomics in hypertension. Current Opinion in Nephrology and Hypertension, 15(2), pp. 145-151. (doi:10.1097/01.mnh.0000203188.57513.3f)

Michelson, G., Warntges, S., Harazny, J., Oehmer, S., Delles, C. and Schmieder, R.E. (2006) Effect of NOS inhibition on retinal arterial and capillary circulation in early arterial hypertension. Retina: The Journal of Retinal and Vitreous Diseases, 26(4), pp. 437-444. (doi:10.1097/01.iae.0000238550.74626.e5)

Oehmer, S., Harazny, J., Delles, C. , Schwarz, T., Handrock, R., Michelson, G. and Schmieder, R. (2006) Valsartan and retinal endothelial function in elderly hypertensive patients. Blood Pressure, 15(3), pp. 185-191. (doi:10.1080/08037050600772680)

Schaufele, T., Schlaich, M., Delles, C. , Klingbeil, A., Fleischmann, E. and Schmieder, R. (2006) Impaired basal NO activity in patients with glomerular disease and the influence of oxidative stress. Kidney International, 70(6), pp. 1177-1181. (doi:10.1038/sj.ki.5001745)

Schmidt, B., Sammer, U., Fleischmann, I., Schlaich, M., Delles, C. and Schmieder, R. (2006) Rapid nongenomic effects of aldosterone on the renal vasculature in humans. Hypertension, 47(4), pp. 650-655. (doi:10.1161/01.HYP.0000205224.58715.cc)

Schneider, M.P., Delles, C. , Schmidt, B.M.W., Oehmer, S., Schwarz, T.K., Schmieder, R.E. and John, S. (2005) Superoxide scavenging effects of N-acetylcysteine and vitamin C in subjects with essential hypertension. American Journal of Hypertension, 18(8), pp. 1111-1117. (doi:10.1016/j.amjhyper.2005.02.006)

John, S., Schneider, M.P., Delles, C. , Jacobi, J. and Schmieder, R.E. (2005) Lipid-independent effects of statins on endothelial function and bioavailability of nitric oxide in hypercholesterolemic patients. American Heart Journal, 149(3), 473.e1-473.e10. (doi:10.1016/j.ahj.2004.06.02)

Dominiczak, A. F. , Graham, D. , McBride, M. W. , Brain, N. J.R., Lee, W. K., Charchar, F. J., Tomaszewski, M., Delles, C. and Hamilton, C. A. (2005) Corcoran Lecture. Cardiovascular genomics and oxidative stress. Hypertension, 45(4), pp. 636-642. (doi:10.1161/01.HYP.0000154253.53134.09)

Schmieder, R., Klingbeil, A., Fleischmann, E., Veelken, R. and Delles, C. (2005) Additional antiproteinuric effect of ultrahigh dose candesartan: A double-blind, randomized, prospective study. Journal of the American Society of Nephrology, 16(10), pp. 3038-3045. (doi:10.1681/ASN.2005020138)

Delles, C. , Klingbeil, A.U., Schneider, M.P., Handrock, R., Schaufele, T. and Schmieder, R.E. (2004) The role of nitric oxide in the regulation of glomerular haemodynamics in humans. Nephrology Dialysis Transplantation, 19(6), pp. 1392-1397. (doi:10.1093/ndt/gfh187)

Delles, C. , Schluter, C., Wittmann, M., Renders, L., Riess, R., Rosch, W., Schott, G., Rupprecht, H. and Kunzendorf, U. (2004) "Very delayed" graft function in a patient after living related kidney transplantation: A case report. Transplantation Proceedings, 36, pp. 1377-1379. (doi:10.1016/j.transproceed.2004.05.015)

Delles, C. , Schluter, C., Wittmann, M., Renders, L., Riess, R., Rosch, W., Schott, G., Rupprecht, H. and Kunzendorf, U. (2004) 'Very delayed' graft function in a patient after living related kidney transplantation: A case report. Transplantation Proceedings, 36(5), pp. 1377-1379. (doi:10.1016/j.transproceed.2004.05.015)

Delles, C. and Schmieder, R. (2004) Effects of the angiotensin-1 receptor blocker valsartan compared with amlodipine on renal hemodynamics - Reply. American Journal of Hypertension, 17(7), pp. 639-640.

Delles, C. and Schmieder, R. (2004) Is the afferent arteriole the main location of nitric oxide action and synthesis in humans? Reply. Nephrology Dialysis Transplantation, 19(11), pp. 2925-2926.

Delles, C. and Schmieder, R. (2004) Renal endothelial effects of anti hypertensive therapy. Current Opinion in Nephrology and Hypertension, 13(5), pp. 489-493.

Delles, C. , Michelson, G., Harazny, J., Oehmer, S., Hilgers, K.F. and Schmieder, R.E. (2004) Impaired endothelial function of the retinal vasculature in hypertensive patients. Stroke, 35(6), pp. 1289-1293. (doi:10.1161/01.STR.0000126597.11534.3b)

Delles, C. , Schneider, M., Oehmer, S., Fleischmann, I., Fleischmann, E.F. and Schmeider, R.E. (2004) Increased response of renal perfusion to the antioxidant vitamin C in type 2 diabetes. Nephrology Dialysis Transplantation, 19(10), pp. 2513-2518. (doi:10.1093/ndt/gfh405)

Fleischmann, E.H., John, S., Delles, C. , Schneider, M.P., Schmidt, B.M.W. and Schmieder, R.E. (2004) The effect of statins on angiotensin II-induced hemodynamic changes in young, mildly hypercholesterolemic men. American Journal of Hypertension, 17(12), pp. 1120-1126. (doi:10.1016/j.amjhyper.2004.07.011)

Schneider, M.P., Klingbeil, A.U., Delles, C. , Ludwig, M., Kolloch, R.E., Krekler, M., Stumpe, K.O. and Schmieder, R.E. (2004) Effect of irbesartan versus atenolol on left ventricular mass and voltage: results of the Cardio Vascular Irbesartan Project. Hypertension, 44(1), pp. 61-66. (doi:10.1161/01.HYP.0000133249.28773.d7)

Delles, C. , Klingbeil, A.U., Schneider, M.P., Handrock, R., Schmieder, R.E. and Weidinger, G. (2003) Direct comparison of the effects of valsartan and amlodipine on renal hemodynamics in human essential hypertension. American Journal of Hypertension, 16(12), pp. 1030-1035. (doi:10.1016/j.amjhyper.2003.07.017)

Schneider, M.P., Klingbeil, A.U., Delles, C. , Schmidt, B.M.W., John, S. and Schmieder, R.E. (2003) Vitamin C augments the renal response to L-arginine in smokers. Nephrology Dialysis Transplantation, 18(8), pp. 1512-1517. (doi:10.1093/ndt/gfg195)

Delles, C. , Schneider, M.P., Oehmer, S., Fleischmann, E.H. and Schmieder, R.E. (2003) L-arginine-induced vasodilation of the renal vasculature is not altered in hypertensive patients with type 2 diabetes. Diabetes Care, 26(6), pp. 1836-1840. (doi:10.2337/diacare.26.6.1836)

Schneider, M.P., Delles, C. , Fleischmann, E., Schmidt, B.M.W., John, S. and Schmieder, R.E. (2003) Effect of elevated triglyceride levels on endothelium-dependent vasodilation in patients with hypercholesterolemia. American Journal of Cardiology, 91(4), pp. 482-484. (doi:10.1016/S0002-9149(02)03255-1)

Delles, C. , Schmidt, B., Muller, H., Oehmer, S., Klingbeil, A. and Schmieder, R. (2003) Functional relevance of aldosterone for the determination of left ventricular mass. American Journal of Cardiology, 91(3), pp. 297-301. (doi:10.1016/S0002-9149(02)03158-2)

Delles, C. and Schmieder, R. (2003) Endothelial function of the human renal vasculature. Deutsche Medizinische Wochenschrift, 128(3), pp. 92-96.

Schmidt, B.M.W., Oehmer, S., Delles, C. , Bratke, R., Schneider, M.P., Klingbeil, A., Fleischmann, E.H. and Schmieder, R.E. (2003) Rapid nongenomic effects of aldosterone on human forearm vasculature. Hypertension, 42(2), pp. 156-160. (doi:10.1161/​01.HYP.0000083298.23119.16)

Schneider, M.P., Hilgers, K.F., Huang, Y., Delles, C. , John, S., Oehmer, S. and Schmieder, R.E. (2003) The C242T p22phox polymorphism and endothelium-dependent vasodilation in subjects with hypercholesterolaemia. Clinical Science, 105(1), pp. 97-103. (doi:10.1042/CS20030003)

Schlaich, M.P., Klingbeil, A.U., Jacobi, J., Delles, C. , Schneider, M.P., Schmidt, B.M. and Schmieder, R.E. (2002) Altered aldosterone response to salt intake and angiotensin II infusion in young normotensive men with parental history of arterial hypertension. Journal of Hypertension, 20(1), pp. 117-24.

Delles, C. , Jacobi, J., John, S., Fleischmann, I. and Schmieder, R. (2002) Effects of enalapril and eprosartan on the renal vascular nitric oxide system in human essential hypertension. Kidney International, 61(4), pp. 1462-1468. (doi:10.1046/j.1523-1755.2002.00260.x)

Delles, C. , Jacobi, J., Schlaich, M., John, S. and Schmieder, R. (2002) Assessment of endothelial function of the renal vasculature in human subjects. American Journal of Hypertension, 15(1), pp. 3-9. (doi:10.1016/S0895-7061(01)02242-7)

Delles, C. , Schneider, M., John, S., Gekle, M. and Schmieder, R. (2002) Angiotensin converting enzyme inhibition and angiotensin II AT(1)-receptor blockade reduce the levels of asymmetrical N-G, N-G-dimethylarginine in human essential hypertension. American Journal of Hypertension, 15(7), pp. 590-593. (doi:10.1016/S0895-7061(02)02278-1)

Delles, C. , Weidner, S., Schobel, H. and Rupprecht, H. (2002) Renal-artery stenosis in a patient with Takayasu's arteritis. Nephrology Dialysis Transplantation, 17(7), pp. 1339-1341. (doi:10.1093/ndt/17.7.1339)

Delles, C. , Wittmann, M., Renders, L., Kunzendorf, U., Bohner, C., Wutke, R., Lang, W., Schott, G. and Rupprecht, H. (2002) Restoration of renal allograft function by endovascular stenting of an iliac artery dissection. Nephrology Dialysis Transplantation, 17(6), pp. 1116-1118. (doi:10.1093/ndt/17.6.1116)

Zeltner, R., Delles, C. , Schneider, M., Siffert, W. and Schmieder, R.E. (2001) G-protein beta(3) subunit gene (GNB3) 825T allele is associated with enhanced renal perfusion in early hypertension. Hypertension, 37(3), pp. 882-886. (doi:10.1161/​01.HYP.37.3.882)

Delles, C. , Erdmann, J., Jacobi, J., Hilgers, K., Fleck, E., Regitz-Zagrosek, V. and Schmieder, R. (2001) Aldosterone synthase (CYP11B2)-344 C/T polymorphism is associated with left ventricular structure in human arterial hypertension. Journal of the American College of Cardiology, 37(3), pp. 878-884. (doi:10.1016/S0735-1097(00)01174-8)

Delles, C. and Schmieder, R. (2001) The kidney in congestive heart failure: Renal adverse event rate of treatment. Journal of Cardiovascular Pharmacology, 38(1), pp. 99-107.

Hilgers, K., Delles, C. , Veelken, R. and Schmieder, R. (2001) Angiotensinogen gene core promoter variants and non-modulating hypertension. Hypertension, 38(6), pp. 1250-1254. (doi:10.1161/hy1201.096545)

John, S., Delles, C. , Jacobi, J., Schlaich, M.P., Schneider, M., Schmitz, G. and Schmieder, R.E. (2001) Rapid improvement of nitric oxide bioavailability after lipid-lowering therapy with cerivastatin within two weeks. Journal of the American College of Cardiology, 37(5), pp. 1351-1358. (doi:10.1016/S0735-1097(01)01128-7)

Leidig, M., Delles, C. , Kuchenbecker, C., Lederle, X., Weidinger, G. and Schmieder, R. (2001) Pharmacokinetics of valsartan in hypertensive patients on long-term haemodialysis. Clinical Drug Investigation, 21(1), pp. 59-66. (doi:10.2165/00044011-200121010-00008)

Schmieder, R., Erdmann, J., Delles, C. , Jacobi, J., Fleck, E., Hilgers, K. and Regitz-Zagrosek, V. (2001) Effect of the angiotensin II type 2-receptor gene (+1675 G/A) on left ventricular structure in humans. Journal of the American College of Cardiology, 37(1), pp. 175-182. (doi:10.1016/S0735-1097(00)01063-9)

Schneider, M., Erdmann, J., Delles, C. , Fleck, E., Regitz-Zagrosek, V. and Schmieder, R. (2001) Functional gene testing of the Glu298Asp polymorphism of the endothelial nitric oxide synthase - Reply. Journal of Hypertension, 19(7), pp. 1341-1342.

Veelken, R., Delles, C. , Hilgers, K. and Schmieder, R. (2001) Outcome survey in unselected hypertensive patients with type 2 diabetes mellitus: effects of ACE inhibition. American Journal of Hypertension, 14(7), pp. 672-678. (doi:10.1016/S0895-7061(01)01300-0)

Book Sections

Delles, C. and Husi, H. (2017) Systems biology approach in hypertension research. In: Touyz, R. M. and Schriffin, E. L. (eds.) Hypertension: Methods and Protocols. Series: Methods in molecular biology, 1527. Springer: New York, pp. 69-79. ISBN 9781493966233 (doi:10.1007/978-1-4939-6625-7_6)

Currie, G. , Matt, P. and Delles, C. (2016) Clinical cardiovascular proteomics. In: Agnetti, G., Lindsey, M. L. and Foster, D. B. (eds.) Manual of Cardiovascular Proteomics. Springer, pp. 389-414. ISBN 9783319318264 (doi:10.1007/978-3-319-31828-8_17)

Conference or Workshop Item

Kohli-Lynch, C.N., Boyd, K. , Briggs, A. and Delles, C. (2017) A Framework for the Cost-Effectiveness Analysis of Novel Biomarker Testing in Cardiovascular Disease. ISPOR 20th Annual European Congress, Glasgow, UK, 4-8 Nov 2017. A404-A405. (doi:10.1016/j.jval.2017.08.040)

This list was generated on Mon Dec 17 10:21:56 2018 GMT.