Chemokines and their receptors are the primary regulars of in vivo leukocyte migration. They are central to immune and inflammatory cell recruitment and are therefore fundamental players in all immune and inflammatory disorders.
We have two major interests:
Firstly, we are interested in trying to understand how chemokines orchestrate the inflammatory response. This is currently poorly understood and a lack of understanding of this important area has contributed, in part, to our failure to therapeutically target chemokines and their receptors in inflammatory disease.
Secondly, we have a very focused interest on members of the atypical chemokine receptor family. These molecules scavenge chemokines and remove them from individual tissue compartments. We are particularly interested in their role in the placenta in preventing chemokines from moving from the mother to the embryo and interfering with cell migration in the embryo. This aspect of our research has implications for our understanding of basic embryonic development and neonatal immune function.
In addition to the above, we are interested in examining chemokine and chemokine receptor involvement in cancer and also in using our understanding of chemokines and their role in cellular migration to improve cellular therapies.
Prof Sue Barnett | Professor of Cellular NeuroscienceDuring our neuro-immunological studies we have identified changes in chemokines including cxcl10, cxcl12 and demonstrated that they can both affect myelination in opposing ways. The former inhibits and the latter promotes. Thus, chemokines can affect neural cell function as well as the immune response. We have also specifically identified a role for Il16 in myelination in models of MS.
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Prof Jonathan Cavanagh | Professor of Psychiatry (Immunology) |
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Prof Gerard Graham | Molecular & Structural ImmunologyMy research focuses on trying to understand chemokines and their receptors, which are the primary regulators of in vivo leukocyte migration. We particularly focus on their roles in inflammation and in development. |
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Prof Pasquale Maffia | Professor of Cardiovascular ImmunologyI have a major interest in the immune response in cardiovascular disease and continue to drive innovative approaches to understand immune responses in atherosclerosis and hypertension. |
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Professor Rick Maizels | Professor (Parasitology)
The Maizels Lab studies how parasites manipulate the immune system through secreted immunomodulators, and how those modulators might offer novel anti-inflammatory therapies. |
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Professor Neal Millar | Professor of Musculoskeletal Science
I am an Academic Consultant Orthopaedic Surgeon based at the University of Glasgow. My laboratory’s research focuses on the immunopathogenesis and translational immunobiology of soft tissue musculoskeletal diseases including tendinopathy, enthesial disease and soft tissue fibrosis. |
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