Institute of Infection, Immunity & Inflammation

Professor Gerard Graham

Professor of Molecular and Structural Immunology (Immunology)
Associate (Institute of Cancer Sciences)
Associate (School of Life Sciences)

telephone: 01413303982
email: Gerard.Graham@glasgow.ac.uk

ORCID iD https://orcid.org/0000-0002-7801-204X

Research interests

Chemokines, Stem Cells and Cancer
We have had a long-standing standing interest in chemokines and their receptors and have been working in this field for 18 years. Currently, we have a number of projects that relate to various aspects of chemokine and chemokine receptor function:Studies into the biological function of the D6-chemokine decoy receptor

In 1997 we reported the cloning of the D6 chemokine receptor. D6 is an atypical receptor and can bind many chemokines with high affinity. Interestingly it does not signal following ligand binding and is thus not a typical chemokine receptor. The chemokines that D6 binds are those that are involved in inflammatory responses. D6 internalises ligand and targets it for intracellular degradation. We have thus proposed a role for D6 as a ‘decoy’ or ‘scavenging’ receptor which is capable of internalising and degrading a range of inflammatory chemokines. We have generated D6-nul mice in collaboration with Dr. Don Cook and Prof Sergio Lira and have shown that these mice display an altered ability to resolve inflammation in both the lung and skin. In the skin, following application of a chemical irritant, these D6-null mice develop a pathology which is similar to human psoriasis. Overall our conclusion is that D6 is an indispensable regulator of the in vivo inflammatory response. We are now undertaking a more detailed investigation of the inflammatory response of the D6 null mice using a range of models. We are also generating D6-GFP reporter mice to help us to detail the key cells that express D6 in the inflamed context and the dynamics of expression of D6 during an inflammatory response.

Studies into the structure of D6
D6, although atypical in the biological sense, is a typical seven transmembrane spanning receptor. There is much interest from the pharmaceutical industry in trying to determine the structure of chemokine receptors to aid rational drug design. Currently the only seven transmembrane spanning receptor structure known is that of Rhodopsin. D6 is curious in that it expresses to extremely high levels in heterologous transfectants and we can purify it to homogeneity in a functional form from transfected mammalian cells. We therefore have a very active interest (in collaboration with Prof Neil Isaacs) in determining the full three dimensional structure of the D6 receptor. It is likely that this structure will provide invaluable information on the structures of the other chemokine receptors and will provide a major boost to attempts to rationally design anti-chemokine receptor drugs.
Therapeutic interference with chemokine receptors

We have developing a number of experimental approaches aimed at examining the ability of chemokine receptors to be used as therapeutic targets. For example we have been ‘shrouding’ adenoviruses with chemokines and have been able to use these altered viruses to specifically infect chemokine receptor expressing cells. Such chemokine-virus conjugates will be of use in introducing a range of gene therapy vectors and even cytotoxic vectors to cells of pathological importance. We are also developing a programme of work in collaboration with ALMAC Sciences which is aimed at producing chemokine variants that will be of therapeutic use in a range of pathologies.
Chemokines and stem cells

We are interested in determining the roles for CXC chemokines in haemopoietic stem cell mobilisation and in the recruitment of neutrophils and neutrophil-derived proteases to the stem cell niche. Embryonic Stem Cell studies: We have a range of interests in murine embryonic stem cells from their use as gene targeting vehicles to the control of the induction of haemopoietic differentiation of ES cells in vitro. We are always keen to talk to researchers interested in working in the above areas or in joining our laboratory to work on related projects.

Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

Deciphering the role of the CCR7/CCL21 chemokine axis in ovarian cancer
Cancer Research UK
2019 - 2021
The ACKR2-CCR2 axis in development and disease
Medical Research Council
2015 - 2020
Basic Science Surgeries
Medical Research Council
2015 - 2017
ONCORNET
European Commission
2015 - 2018
Enhancing vascular cell therapy by manipulating chemokine receptor expression
British Heart Foundation
2014 - 2016
Royal Society Wolfson Research Merit Award
The Royal Society
2014 - 2019
Developing small molecule antagonists of the ACKR2 chemokine-scavenging receptor.
Medical Research Council
2014 - 2015
Rheumatoid Arthritis Centre of Excellence (RACE - Towards a Cure)
Arthritis Research UK
2013 - 2019
The role of microRNA 29 in tendon disease
Wellcome Trust
2013 - 2017
The development of chemokines as novel clinical grade cell-sorting tools
Chief Scientist Office
2013 - 2015
Defining the Role of Cell Migration in the Initiation and Regulation of Pathogenesis in Inflammatory Arthritis
Arthritis Research UK
2013 - 2019
Dissecting the chemokine basis for the orchestration of the in vivo inflammatory response
Wellcome Trust
2013 - 2019
Evaluating the Chemokine receptor D6 as a marker and therapeutic target in cutaneous inflammatory disease
Wellcome Trust
2012 - 2015
The FLEXCELL FX-5000T Tension System; reintroducing cyclical mechanical strain to cell culture systems
Arthritis Research UK
2012 - 2013
TIMER
European Commission
2012 - 2015
Understanding and manipulating chemokines and their receptors in the context of adjuvants
Biotechnology and Biological Sciences Research Council
2011 - 2014
Chemokine-mediated innate immune responses to arthropod bites and their viruses
Medical Research Council
2011 - 2014
Leucocyte expression of the D6 chemokine decoy receptor in the pathogenesis of rheumatoid arthritis
Arthritis Research UK
2011 - 2013
Assessing the value and function of D6 as a novel prognostic marker of inflammatory diseases
Chief Scientist Office
2011 - 2013
Improving Cellular Fitness for Therapy: the Novel Use of Chemokines as cell Sorting Agents
Chief Scientist Office
2011 - 2013
Regulation of the adaptive immune response by chemokine scavenging receptors
Medical Research Council
2010 - 2015
An investigation into the molecular basis for B lineage acute lymphoblastic leukaemia migration to extramedullary sites.rn
The Kay Kendall Leukaemia Fund
2010 - 2013
Defining the chemokine receptor expression repertoire of CNS derived pathogenic T cells - 2009-01
Neurosciences Foundation
2010 - 2011
In Vivo Reporting using Nanosystems Chemistry and Optical Spectroscopy
Engineering and Physical Sciences Research Council
2010 - 2011
Generation of antibodies against the chemokine CXCL12 for cancer therapy
Cancer Research UK
2009 - 2010
The role of IL-35 in infection and inflammation
Medical Research Council
2009 - 2012
The chemokine decoy receptor D6 in Rheumatoid Arthritis and Inflammation
Arthritis Research UK
2009 - 2012
An immuno-histological and molecular investigation into the association of the chemokine decoy receptor D6 with psoriasis.
Scottish Executive Health Department
2009 - 2011
Investigation into the role of the atypical chemokine receptor D6 in atherosclerosis: murine and human studies
British Heart Foundation
2009 - 2012
DPFS Resource Request (University of Glasgow)
Medical Research Council
2009 - 2011
Assessment of Myoglobin as a Novel MR Reporter Gene and its potential to protect Embryonic Stem Cells against hypoxia
Neurosciences Foundation
2009 - 2010
Toll like receptors and chemokine receptors - 2 interconnected arms of the innate immune response
Medical Research Council
2008 - 2011
An investigation of the roles for leukocyte and lymphatic endothelial cell D6 in the orchestration of the in vivo inflammatory response
Wellcome Trust
2007 - 2010
An investigation of the roles for D6 in lung inflammation
Tenovus Scotland
2007 - 2008
An investigation of the in vivo function of the D6 chemokine decoy receptor
Biotechnology and Biological Sciences Research Council
2007 - 2010
Polyvalent protein-ligand displays for human endometrial stromal cell and embryonic stem cell adhesion, differentiation and proliferation.
Biotechnology and Biological Sciences Research Council
2007 - 2009
INNOCHEM - Innovative Chemokine-based Therapeutic Strategies for Autoimmunity and Chronic Inflammation
European Commission
2007 - 2010
The role of CXCR2 ligands in haemopoietic stem cell mobilisation
Leukaemia & Lymphoma Research
2006 - 2008
Pro-inflammatory chemokine function in de novo tumorigenesis
Cancer Research UK
2006 - 2009
The structure and function of the beta chemokine receptor D6 - a member of the family of G protein coupled receptors
Biotechnology and Biological Sciences Research Council
2006 - 2009
An investigation of the role of the chemokine receptor D6 in placental dysfunction
Scottish Hospital Endowments Research Trust
2005 - 2007
Fluorescence-activated cell sorting and analysing in studies of normal and malignant human murine haemopoiesis
Leukaemia & Lymphoma Research
2005 - 2008
Chemokine receptors and lymphoma:novel options for therapy
Leukaemia & Lymphoma Research
2004 - 2007
Chemokines, stem cells and cancer
Cancer Research UK
2004 - 2006
Cloning and Characterisation of a novel receptor for the chemokine MIF-1 Alpha
Leukaemia & Lymphoma Research
2004 - 2006
Elucidating immune mechanisms in inflammatory arthritis
Nuffield Foundation
2004 - 2013
An investigation into the molecular pathology of DS-AMKL
Leukaemia & Lymphoma Research
2004 - 2009
An investigation into the roles for RIN3 in normal haemopoiesis and leukaemia
Leukaemia & Lymphoma Research
2004 - 2007
An investigation of the relevance of quiescent Ph+ stem cells to eradication of chronic myeloid leukaemia
Leukaemia & Lymphoma Research
2003 - 2007
A determination of the cell cycle specific transcriptional profile of human haemopoietic stem cells - comparison of normal versus ......
Scottish Executive Health Department
2003 - 2006
Structural studies on the beta chemokine receptor D6
Biotechnology and Biological Sciences Research Council
2000 - 2006

Publications

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Number of items: 96.

2019

Lee, K. M., Wilson, G. J. , Pingen, M., Fukuoka, A. , Hansell, C. A.H., Bartolini, R., Medina-Ruiz, L. and Graham, G. J. (2019) Placental chemokine compartmentalisation: a novel mammalian molecular control mechanism. PLoS Biology, 17(5), e3000287. (doi:10.1371/journal.pbio.3000287) (PMID:31141500) (PMCID:PMC6557524)

Graham, G. J. , Handel, T. M. and Proudfoot, A. E.I. (2019) Leukocyte adhesion: reconceptualizing chemokine presentation by glycosaminoglycans. Trends in Immunology, (doi:10.1016/j.it.2019.03.009) (PMID:31006548) (Early Online Publication)

Dyer, D. P. , Nebot, J. B., Kelly, C. J., Medina-Ruiz, L., Schuette, F. and Graham, G. J. (2019) The chemokine receptor CXCR2 contributes to murine adipocyte development. Journal of Leukocyte Biology, 105(3), pp. 497-506. (doi:10.1002/JLB.1A0618-216RR) (PMID:30517976) (PMCID:PMC6392114)

Dyer, D. P. et al. (2019) Chemokine receptor redundancy and specificity are context dependent. Immunity, 50(2), 378-389.e5. (doi:10.1016/j.immuni.2019.01.009) (PMID:30784579) (PMCID:PMC6382461)

2018

Hansell, C. A.H. et al. (2018) The atypical chemokine receptor Ackr2 constrains NK cell migratory activity and promotes metastasis. Journal of Immunology, 201(8), pp. 2510-2519. (doi:10.4049/jimmunol.1800131) (PMID:30158126) (PMCID:PMC6176105)

Castanheira, F. V. E. S. et al. (2018) The atypical chemokine receptor ACKR2 is protective against sepsis. Shock, 49(6), pp. 682-689. (doi:10.1097/SHK.0000000000000969) (PMID:29589840)

Shams, K., Kurowska-Stolarska, M. , Schütte, F., Burden, A. D., McKimmie, C. S. and Graham, G. J. (2018) MicroRNA-146 and cell trauma down-regulate expression of the psoriasis-associated atypical chemokine receptor ACKR2. Journal of Biological Chemistry, 293(8), pp. 3003-3012. (doi:10.1074/jbc.M117.809780) (PMID:29279330) (PMCID:PMC5827444)

Leighton, S.P. , Nerurkar, L., Krishnadas, R., Johnman, C., Graham, G.J. and Cavanagh, J. (2018) Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis. Molecular Psychiatry, 23(1), pp. 48-58. (doi:10.1038/mp.2017.205) (PMID:29133955) (PMCID:PMC5754468)

2017

Nerurkar, L., McColl, A., Graham, G. and Cavanagh, J. (2017) The systemic response to topical Aldara treatment is mediated through direct TLR7 stimulation as Imiquimod enters the circulation. Scientific Reports, 7(1), 16570. (doi:10.1038/s41598-017-16707-5) (PMID:29185473) (PMCID:PMC5707416)

Baldwin, H. M., Singh, M. D., Codullo, V., King, V., Wilson, H., McInnes, I. and Graham, G. J. (2017) Elevated ACKR2 expression is a common feature of inflammatory arthropathies. Rheumatology, 56(9), pp. 1607-1617. (doi:10.1093/rheumatology/kex176) (PMID:28486662) (PMCID:PMC5850605)

Dyer, D. P. , Pallas, K., Medina Ruiz, L., Schuette, F., Wilson, G. J. and Graham, G. J. (2017) CXCR2 deficient mice display macrophage-dependent exaggerated acute inflammatory responses. Scientific Reports, 7, 42681. (doi:10.1038/srep42681) (PMID:28205614) (PMCID:PMC5311995)

Graham, G. et al. (2017) Spread of psoriasiform inflammation to remote tissues is restricted by the atypical chemokine receptor ACKR2. Journal of Investigative Dermatology, 137(1), pp. 85-94. (doi:10.1016/j.jid.2016.07.039) (PMID:27568525) (PMCID:PMC5176004)

Wilson, G. J. , Hewit, K. D., Pallas, K. J., Cairney, C. J., Lee, K. M., Hansell, C. A., Stein, T. and Graham, G. J. (2017) Atypical chemokine receptor ACKR2 controls branching morphogenesis in the developing mammary gland. Development, 144, pp. 74-82. (doi:10.1242/dev.139733) (PMID:27888192) (PMCID:PMC5278629)

2016

Sinclair, A. et al. (2016) CXCR2 and CXCL4 regulate survival and self-renewal of hematopoietic stem/progenitor cells. Blood, 128(3), pp. 371-383. (doi:10.1182/blood-2015-08-661785) (PMID:27222476) (PMCID:PMC4991087)

Pingen, M., Bryden, S. R., Pondeville, E., Schnettler, E., Kohl, A. , Merits, A., Fazakerley, J. K., Graham, G. J. and McKimmie, C. S. (2016) Host inflammatory response to mosquito bites enhances the severity of arbovirus infection. Immunity, 44(6), pp. 1455-1469. (doi:10.1016/j.immuni.2016.06.002) (PMID:27332734) (PMCID:PMC4920956)

Mccoll, A., Thomson, C. A., Nerurkar, L., Graham, G. J. and Cavanagh, J. (2016) TLR7-mediated skin inflammation remotely triggers chemokine expression and leukocyte accumulation in the brain. Journal of Neuroinflammation, 13, 102. (doi:10.1186/s12974-016-0562-2) (PMID:27160148)

Bryce, S. A., Wilson, R. A.M., Tiplady, E. M. , Asquith, D. L., Bromley, S. K., Luster, A. D., Graham, G. J. and Nibbs, R. J.B. (2016) ACKR4 on stromal cells scavenges CCL19 to enable CCR7-dependent trafficking of APCs from inflamed skin to lymph nodes. Journal of Immunology, 196(8), pp. 3341-3353. (doi:10.4049/jimmunol.1501542) (PMID:26976955)

Bonecchi, R. and Graham, G. J. (2016) Atypical chemokine receptors and their roles in the resolution of the inflammatory response. Frontiers in Immunology, 7, 224. (doi:10.3389/fimmu.2016.00224)

Williams, M. T.S. et al. (2016) The ability to cross the blood-cerebrospinal fluid barrier is a generic property of acute lymphoblastic leukaemia blasts. Blood, 127, 16. (doi:10.1182/blood-2015-08-665034) (PMID:26869395)

2015

Bachelerie, F., Graham, G.J. , Locati, M., Mantovani, A., Murphy, P.M., Nibbs, R. , Rot, A., Sozzani, S. and Thelen, M. (2015) An atypical addition to the chemokine receptor nomenclature: IUPHAR Review 15. British Journal of Pharmacology, 172(16), pp. 3945-3949. (doi:10.1111/bph.13182) (PMID:25958743)

Le Brocq, M., Fraser, A. R., Graham, G. J. and Campbell, J. D.M. (2015) CCL19-sorted mature dendritic cells have enhanced lymph node migratory capacity and function. Journal of Inflammation, 12(S1), P2. (doi:10.1186/1476-9255-12-S1-P2) (PMCID:PMC4416168)

2014

Li, D. et al. (2014) IL-33 promotes ST2-dependent lung fibrosis by the induction of alternatively activated macrophages and innate lymphoid cells in mice. Journal of Allergy and Clinical Immunology, 134(6), 1422-1432.e11. (doi:10.1016/j.jaci.2014.05.011)

Elmesmari, A., Gilchrist, D. S., Fraser, A. R., Graham, G. J. , Brewer, J. , Kurowska-Stolarska, M. and McInnes, I. B. (2014) Mir-155 Expression Correlates with Clinical Disease Activity and has Effector Function in Rheumatoid Arthritis. 2014 ACR/ARHP Annual Meeting, Boston, MA, 14-19 Nov 2014. (Unpublished)

Lee, K. M., Danuser, R., Stein, J. V., Graham, D. , Nibbs, R. J.B. and Graham, G. J. (2014) The chemokine receptors ACKR2 and CCR2 reciprocally regulate lymphatic vessel density. EMBO Journal, 33(21), pp. 2564-2580. (doi:10.15252/embj.201488887)

Michlmayr, D., McKimmie, C.S., Pingen, M., Haxton, B., Mansfield, K., Johnson, N., Fooks, A.R. and Graham, G.J. (2014) Defining the chemokine basis for leukocyte recruitment during viral encephalitis. Journal of Virology, 88(17), pp. 9553-9567. (doi:10.1128/JVI.03421-13)

Ford, L. B., Cerovic, V., Milling, S. W.F. , Graham, G. J. , Hansell, C. A.H. and Nibbs, R. J.B. (2014) Characterization of conventional and atypical receptors for the chemokine CCL2 on mouse leukocytes. Journal of Immunology, 193(1), pp. 400-411. (doi:10.4049/jimmunol.1303236)

Zakrys, L., Ward, R. J., Pediani, J. D. , Godin, A. G., Graham, G. J. and Milligan, G. (2014) Roundabout 1 exists predominantly as a basal dimeric complex and this is unaffected by binding of the ligand Slit2. Biochemical Journal, 461(1), pp. 61-73. (doi:10.1042/BJ20140190)

Le Brocq, M. L., Fraser, A. R., Cotton, G., Woznica, K., McCulloch, C. V., Hewit, K. D., McKimmie, C. S., Nibbs, R. J.B. , Campbell, J. D.M. and Graham, G. J. (2014) Chemokines as novel and versatile reagents for flow cytometry and cell sorting. Journal of Immunology, 192(12), pp. 6120-6130. (doi:10.4049/jimmunol.1303371) (PMID:24850722)

Elmesmari, A., Gilchrist, D. S., Fraser, A. R., Vaughan, D. , Graham, G. J. , Brewer, J. , Kurowska-Stolarska, M. and McInnes, I. B. (2014) MicroRNA-155 Regulates Chemokines and Chemokine Receptors in Rheumatoid Arthritis Monocytes. Libya Higher Education Forum, London, UK, 5-6 June 2014. (Unpublished)

Hewit, K. D., Fraser, A., Nibbs, R. J.B. and Graham, G. J. (2014) The N-terminal region of the atypical chemokine receptor ACKR2 is a key determinant of ligand binding. Journal of Biological Chemistry, 289(18), pp. 12330-12342. (doi:10.1074/jbc.M113.534545)

Anselmo, A., Mazzon, C., Borroni, E. M., Bonecchi, R., Graham, G. J. and Locati, M. (2014) Flow cytometry applications for the analysis of chemokine receptor expression and function. Cytometry Part A, 85(4), pp. 292-301. (doi:10.1002/cyto.a.22439)

Bachelerie, F., Graham, G.J. , Locati, M., Mantovani, A., Murphy, P.M., Nibbs, R. , Rot, A., Sozzani, S. and Thelen, M. (2014) New nomenclature for atypical chemokine receptors. Nature Immunology, 15(3), pp. 207-208. (doi:10.1038/ni.2812)

Bachelerie, F. et al. (2014) International union of pharmacology. LXXXIX. update on the extended family of chemokine receptors and introducing a new nomenclature for atypical chemokine receptors. Pharmacological Reviews, 66(1), pp. 1-79. (doi:10.1124/pr.113.007724)

Guabiraba Brito, R. et al. (2014) IL-33 targeting attenuates intestinal mucositis and enhances effective tumor chemotherapy in mice. Mucosal Immunology, 7(5), pp. 1079-1093. (doi:10.1038/mi.2013.124)

Thomson, C. A., McColl, A., Cavanagh, J. and Graham, G. J. (2014) Peripheral inflammation is associated with remote global gene expression changes in the brain. Journal of Neuroinflammation, 11(73), (doi:10.1186/1742-2094-11-73)

Williams, M. T.S. et al. (2014) Interleukin-15 enhances cellular proliferation and up-regulates CNS homing molecules in pre-B acute lymphoblastic leukemia. Blood, 123(20), pp. 3116-3127. (doi:10.1182/blood-2013-05-499970) (PMID:24700781)

2013

Baldwin, H.M., Pallas, K., King, V., Jamieson, T., McKimmie, C.S., Nibbs, R.J.B. , Carballido, J.M., Jaritz, M., Rot, A. and Graham, G.J. (2013) Microarray analyses demonstrate the involvement of type i interferons in psoriasiform pathology development in D6-deficient mice. Journal of Biological Chemistry, 288(51), pp. 36473-36483. (doi:10.1074/jbc.M113.491563)

Yasar, M. Y. et al. (2013) 3866 An Analysis of Mechanisms of Central Nervous System Infiltration in Acute Lymphoblastic Leukaemia Using Primary Cells Xenografted Into Immunodeficient Mice. 55th ASH Annual Meeting and Exposition, New Orleans, LA, USA, 7-10 Dec 2013.

Rot, A., McKimmie, C., Burt, C.L., Pallas, K.J., Jamieson, T., Pruenster, M., Horuk, R., Nibbs, R.J.B. and Graham, G.J. (2013) Cell-autonomous regulation of neutrophil migration by the D6 chemokine decoy receptor. Journal of Immunology, 190(12), pp. 6450-6456. (doi:10.4049/jimmunol.1201429)

McKimmie, C.S. et al. (2013) An analysis of the function and expression of D6 on lymphatic endothelial cells. Blood, 121(18), pp. 3768-3777. (doi:10.1182/blood-2012-04-425314)

Graham, G.J. and Locati, M. (2013) Regulation of the immune and inflammatory responses by the 'atypical' chemokine receptor D6. Journal of Pathology, 229(2), pp. 168-175. (doi:10.1002/path.4123)

Lee, K., Nibbs, R.J.B. and Graham, G.J. (2013) D6: the 'crowd controller’ at the immune gateway. Trends in Immunology, 34(1), pp. 7-12. (doi:10.1016/j.it.2012.08.001)

Oleinika, K., Nibbs, R.J. , Graham, G.J. and Fraser, A.R. (2013) Suppression, subversion and escape: the role of regulatory T cells in cancer progression. Clinical and Experimental Immunology, 171(1), pp. 36-45. (doi:10.1111/j.1365-2249.2012.04657.x)

Mori, M., Andersson, C.K., Graham, G.J. , Löfdahl, C.G. and Erjefält, J.S. (2013) Increased number and altered phenotype of lymphatic vessels in peripheral lung compartments of patients with COPD. Respiratory Research, 14(65), (doi:10.1186/1465-9921-14-65)

Nibbs, R.J.B. and Graham, G.J. (2013) Immune regulation by atypical chemokine receptors. Nature Reviews Immunology, 13(11), pp. 815-829. (doi:10.1038/nri3544)

2012

Singh, M.D. et al. (2012) Elevated expression of the chemokine-scavenging receptor D6 is associated with impaired lesion development in psoriasis. American Journal of Pathology, 181(4), pp. 1158-1164. (doi:10.1016/j.ajpath.2012.06.042) (PMID:22867710) (PMCID:PMC3532592)

Akbar, M., Fraser, A. R., Graham, G. J. , Brewer, J. M. and Grant, M. H. (2012) Acute inflammatory response to cobalt chromium orthopaedic wear debris in a rodent air-pouch model. Journal of the Royal Society: Interface, 9(74), pp. 2109-2119. (doi:10.1098/rsif.2012.0006)

Graham, G.J. , Locati, M., Mantovani, A., Rot, A. and Thelen, M. (2012) The biochemistry and biology of the atypical chemokine receptors. Immunology Letters, 145(1-2), pp. 30-38. (doi:10.1016/j.imlet.2012.04.004)

Elmesmari, A., Gilchrist, D. S., Fraser, A. D., Vaughan, D., McQueenie, R., Graham, G. , Brewer, J. , McInnes, I. B. and Kurowska-Stolarska, M. (2012) Microrna-155 regulates chemokines and chemokine receptors in Rheumatoid Arthritis monocyte. In: American College of Rheumatology & Association of Rheumatology Health Professionals, Annual Scientific Meeting, Washington DC, USA, 9-14 Nov 2012, S384. (doi:10.1002/art.37735)

Halsey, C. , Docherty, M., McNeill, M., Gilchrist, D., Le Brocq, M., Gibson, B. and Graham, G. (2012) The GATA1s isoform is normally down-regulated during terminal haematopoietic differentiation and over-expression leads to failure to repress MYB, CCND2 and SKI during erythroid differentiation of K562 cells. Journal of Hematology and Oncology, 5, p. 45. (doi:10.1186/1756-8722-5-45)

2011

Lee, K. M. et al. (2011) D6 facilitates cellular migration and fluid flow to lymph nodes by suppressing lymphatic congestion. Blood, 118(23), pp. 6220-6229. (doi:10.1182/blood-2011-03-344044)

Hueber, A. J., Alves-Filho, J. C., Asquith, D. L., Michels, C., Millar, N. L. , Reilly, J. H., Graham, G. J. , Liew, F. Y., Miller, A. M. and McInnes, I. B. (2011) IL-33 induces skin inflammation with mast cell and neutrophil activation. European Journal of Immunology, 41(8), pp. 2229-2237. (doi:10.1002/eji.201041360) (PMID:21674479)

Williams, M.T., Graham, G. , Gibson, B. and Halsey, C. (2011) Homing to the central nervous system is associated with differential expression of selectins, integrins and chemokine receptors in pre-B acute lymphoblastic leukaemia cell lines. In: 51st Annual Scientific Meeting of the British Society for Haematology, Brighton, UK, 4-6 April 2011, pp. 1-88. (doi:10.1111/j.1365-2141.2011.08609.x)

Williams, M.T., Graham, G. , Gibson, B. and Halsey, C. (2011) An investigation into the role of interleukin-15 on the growth and survival of pre-B acute lymphoblastic leukaemia cell lines. In: 51st Annual Scientific Meeting of the British Society for Haematology, Brighton, UK, 4-6 April 2011, pp. 1-88. (doi:10.1111/j.1365-2141.2011.08609.x)

Codullo, V. et al. (2011) An investigation of the inflammatory cytokine and chemokine network in systemic sclerosis. Annals of the Rheumatic Diseases, 70(6), pp. 1115-1121. (doi:10.1136/ard.2010.137349) (PMID:21285114)

2010

Singh, M., Nibbs, R.J. and Graham, G.J. (2010) The atypical chemokine receptors. In: Smit, M.J., Lira, S.A. and Leurs, R. (eds.) Chemokine Receptors as Drug Targets. Wiley-VCH: Weinheim, Germany. ISBN 9783527632008

Bradford, L., Marshall, H., Robertson, H., Kirby, J. A., Graham, G. , Ali, S. and O'Boyle, G. (2010) Cardiac Allograft Rejection: Examination of the Expression and Function of the Decoy Chemokine Receptor D6. Transplantation, 89(11), pp. 1411-1416. (doi:10.1097/TP.0b013e3181da604b)

Halsey, C. , Tunstall, O., Gibson, B., Roberts, I. and Graham, G. (2010) Role of GATA-1s in early hematopoiesis and differences between alternative splicing in human and murine GATA-1. Blood, 115(16), pp. 3415-3416. (doi:10.1182/blood-2010-02-267930)

Henriques, C. M., Rino, J., Nibbs, R. J. , Graham, G. J. and Barata, J. T. (2010) IL-7 induces rapid clathrin-mediated internalization and JAK3-dependent degradation of IL-7R alpha in T cells. Blood, 115(16), pp. 3269-3277. (doi:10.1182/blood-2009-10-246876)

Madigan, J. et al. (2010) Chemokine Scavenger D6 Is Expressed by Trophoblasts and Aids the Survival of Mouse Embryos Transferred into Allogeneic Recipients. Journal of Immunology, 184(6), pp. 3202-3212. (doi:10.4049/jimmunol.0902118)

McKimmie, C. S. and Graham, G. J. (2010) Astrocytes modulate the chemokine network in a pathogen-specific manner. Biochemical and Biophysical Research Communications, 394(4), pp. 1006-1011. (doi:10.1016/j.bbrc.2010.03.111)

2009

Singh, M.D., Kreiner, M., McKimmie, C.S., Holt, S., van der Walle, C.F. and Graham, G.J. (2009) Dimeric integrin alpha 5 beta 1 ligands confer morphological and differentiation responses to murine embryonic stem cells. Biochemical and Biophysical Research Communications, 390(3), pp. 716-721. (doi:10.1016/j.bbrc.2009.10.035)

Asquith, D., Miller, A., Hueber, A., McKinnon, H., Sattar, N. , Graham, G. and McInnes, I. (2009) Liver X receptor agonism promotes articular inflammation in murine collagen-induced arthritis. Arthritis and Rheumatism, 60(9), pp. 2655-2665. (doi:10.1002/art.24717) (PMID:19714646)

McKimmie, C. S. et al. (2009) A TLR2 ligand suppresses inflammation by modulation of chemokine receptors and redirection of leukocyte migration. Blood, 113(18), pp. 4224-4231. (doi:10.1182/blood-2008-08-174698) (PMID:19202130)

Graham, G. (2009) D6 and the atypical chemokine receptor family: Novel regulators of immune and inflammatory processes. European Journal of Immunology, 39(2), pp. 342-351. (doi:10.1002/eji.200838858)

Nibbs, R. J.B. , McLean, P., McCulloch, C., Riboldi‐Tunnicliffe, A., Blair, E., Zhu, Y., Isaacs, N. and Graham, G. J. (2009) Structure–function dissection of D6, an atypical scavenger receptor. In: Abelson, J. N. and Simon, M. I. (eds.) Chemokines, Part A. Series: Methods in enzymology (460). Academic Press: Amsterdam, pp. 245-261. ISBN 9780123749086 (doi:10.1016/S0076-6879(09)05212-4)

Patel, M., McInnes, I. and Graham, G. (2009) Atypical Chemokine Receptors in Inflammatory Disease. Current Molecular Medicine, 9(1), pp. 86-93. (doi:10.2174/156652409787314480) (PMID:19199944)

Pruenster, M. et al. (2009) The Duffy antigen receptor for chemokines transports chemokines and supports their promigratory activity. Nature Immunology, 10(1), pp. 101-108. (doi:10.1038/ni.1675)

2008

McKimmie, C. S. et al. (2008) Hemopoietic cell expression of the chemokine decoy receptor D6 is dynamic and regulated by GATA1. Journal of Immunology, 181(5), pp. 3353-3363. (doi:10.4049/jimmunol.181.11.8170-a) (PMID:19039854)

Deruaz, M. et al. (2008) Ticks produce highly selective chemokine binding proteins with antiinflammatory activity. Journal of Experimental Medicine, 205(9), pp. 2019-2031. (doi:10.1084/jem.20072689)

McCulloch, C., Morrow, V., Milasta, S., Comerford, I., Milligan, G. , Graham, G. , Isaacs, N. and Nibbs, R. (2008) Multiple roles for the C-terminal tail of the chemokine scavenger D6. Journal of Biological Chemistry, 283(12), pp. 7972-7982. (doi:10.1074/jbc.M710128200)

Truman, L. et al. (2008) CX3CL1/fractalkine is released from apoptotic lymphocytes to stimulate macrophage chemotaxis. Blood, 112(13), pp. 5026-5036. (doi:10.1182/blood-2008-06-162404)

2007

Nibbs, R. J.B. , Gilchrist, D. S., King, V., Ferra, A., Forrow, S., Hunter, K. D. and Graham, G. J. (2007) The atypical chemokine receptor D6 suppresses the development of chemically induced skin tumors. Journal of Clinical Investigation, 117(7), pp. 1884-1892. (doi:10.1172/JCI30068)

Halsey, C. , Fisher, C., Strathdee, G., Gibson, B., Holyoake, T., Vyas, P. and Graham, G. (2007) GATA1 mutational analysis in chronic myeloid leukaemia. British Journal of Haematology, 137(4), pp. 375-376. (doi:10.1111/j.1365-2141.2007.06563.x) (PMID:17408401)

Card, J. W., Cook, D. N., DeGraff, L. M., Graham, G. J. , Lira, S. A., Wang, T. and Whitehead, G. S. (2007) The chemokine receptor D6 has opposing effects on allergic inflammation and airway reactivity. American Journal of Respiratory and Critical Care Medicine, 175(3), pp. 243-249. (doi:10.1164/rccm.200606-839OC)

Graham, G.J. and Nibbs, R.J. (2007) Chemokine receptors: a structural overview. In: Harrison, J.K. and Lukacs, N.W. (eds.) The Chemokine Receptors. Series: Receptors. Humana Press: Totowa, NJ, pp. 31-54. ISBN 978-1-58829-773-0

Graham, S., Vass, J., Holyoake, T. and Graham, G. (2007) Transcriptional analysis of quiescent and proliferating CD34+human hemopoietic cells from normal and chronic myeloid leukemia sources. Stem Cells, 25(12), pp. 3111-3120. (doi:10.1634/stemcells.2007-0250)