Drug Resistance in Livestock Trypanosomes

Trypanosomiasis can also infect animals, where it can cause reduced fertility and milk production and possibly the death of the animal. Such impacts are critical for those who rely on livestock for their livelihoods. As the parasite's resistance to available treatments becomes more common, new tool are needed to tackle this threat.

Researchers at the University of Glasgow are part of a collaborative team including researchers from University of Strathclyde, the Roslin Institute at the University of Edinburgh who are working with GALVmed, a not-for-profit veterinary health charity based in Scotland that develops vaccines and drugs for livestock diseases. The team is creating and testing different combinations of chemical compounds to see which are the most effective against trypanosome infection. It's the job of the Glasgow team to test for efficacy and try to understand why some compounds work better than others.

A project that started in 2019 is investigating drug resistance in the field. By exploring how trypanosomes spread in the natural environment, the researchers hope to identify target pathways for future drug treatments.

First published: 21 January 2021