Mapping the Molecular Landscapes of Ageing and Resilience
Supervisors:
Prof Nicholas JW Rattray, University of Strathclyde
Prof Colin Selman, University of Glasgow
Prof Ken Chen, University of Strathclyde
CASE INDUSTRY PARTNER: Virax Biolabs UK Ltd
Summary:
This interdisciplinary PhD project investigates the biochemical foundations of ageing, frailty, and resilience across the mammalian lifespan. Using targeted metabolomics, proteomics, and immune profiling, the student will analyse longitudinal data from human surgical cohorts to identify molecular signatures linked to stress responses. These findings will be translated into murine models to explore causal mechanisms and test interventions. Advanced computational modelling will then be used to uncover conserved ageing pathways and develop predictive resilience biomolecular clocks.
The student will gain expertise in molecular biology, bioinformatics, and systems modelling, with hands-on training in omics technologies, longitudinal data analysis, and cross-species biology. A key component involves collaboration with Virax Biolabs, who will provide specialist training in immune antibody profiling, assay development, and translational immunology using proprietary platforms. Training will also cover statistical modelling (e.g., mixed models, GAMs), multi-omics integration (MOFA, DIABLO), and pathway-level alignment. Working across clinical, animal, and computational teams will foster strong communication, project management, and translational research skills.
This project offers a unique opportunity to contribute to cutting-edge ageing research while developing a skill set highly valued in academia, biotech, and healthcare. Graduates will be well-prepared for careers in bioscience innovation, precision medicine, and data-driven health research.