Defining the impact of meat-derived nitrite metabolites on mammalian metabolic homeostasis and intestinal epithelial adaptation
Supervisors:
Prof Brian Green, Queens University Belfast
Dr Johan Vande Voorde, University of Glasgow
Dr Emma Kerr, Queens University Belfast
CASE PARTNER: Estom Ltd (Properoni)
Summary:
Dietary exposure to nitrite-preserved processed meats generates diverse N-nitroso compounds (NOCs) that impact cellular homeostasis, yet their distinct mechanistic effects remain unresolved. In this BBSRC CASE studentship, you will investigate how specific food-derived nitrite metabolites alter colorectal epithelial adaptation and systemic mammalian metabolism. Partnering with the innovative UK SME Estom Ltd. (Properoni®), specialists in nitrite-free meat production, you will compare standard cured and nitrite-free matrices to uncover how dietary components regulate fundamental tissue resilience.
Based across Queen’s University Belfast and the University of Glasgow, you will receive comprehensive interdisciplinary training in state-of-the-art techniques:
• Food chemistry & analytical metabolomics (Prof. Brian Green)
• 3D intestinal organoid culture & epithelial biology (Dr. Emma Kerr)
• Stable isotope tracing & cellular metabolic flux (Dr. Johan Vande Voorde)
A dedicated 3-month placement with Estom Ltd. will provide direct commercial R&D experience, including project management and business strategy. Supported by the NorthWestBio programme’s tailored professional development, you will graduate as a highly adaptable bioscience researcher equipped with elite technical, computational, and commercial skills for careers across academia, biotechnology, or the food industry.