Seaweed-Derived Fucoidans as Modulators of Macrophage Plasticity: Exploring the Role of Autophagy
Supervisors
Dr Maha Abdollah, Lancaster University
Prof Maria Ascierto, University of Glasgow
Dr Lucy Jackson-Jones, Lancaster University
Summary
Fucoidan is a naturally occurring sulphated polysaccharide found in edible brown seaweeds, which are becoming increasingly popular in healthy diets, dietary supplements and so-called “superfoods”. Yet, we still know relatively little about how their bioactive components interact with our immune system. Fucoidans also vary considerably between seaweed species, raising an important question: do they all have the same biological effects?
This PhD project will compare fucoidans from three abundant brown seaweeds found around the UK coastline: bladder wrack (Fucus vesiculosus), serrated wrack (Fucus serratus) and egg wrack/rockweed (Ascophyllum nodosum). The project will investigate how these fucoidans influence macrophage plasticity. These highly adaptable immune cells can change their behaviour in response to their environment and play important roles in inflammation, immunity and tissue repair. We will explore whether these effects are linked to autophagy, the cell’s recycling and defence system, and investigate the signalling pathways involved.
The student will gain broad training in cell culture, immunology, molecular and cellular pharmacology, autophagy and functional assays. They will also receive training in advanced immune profiling, including flow and spectral cytometry through the collaboration with the University of Glasgow. Working across both institutions will provide valuable experience in interdisciplinary research, experimental design, data analysis and scientific communication.