The role of spatial and temporal mRNA expression in regulating astrocyte reactivity in health and disease.
Supervisors:
Trevor Bushell, Strathclyde Institute of Pharmacy & Biomedical Sciences, University of Strathclyde
Summary:
Astrocytes, the most abundant glial cell in the central nervous system (CNS), have been recently recognized as playing a central role in ageing and neurodegenerative diseases. In particular, reactive astrocytes, whose number are increased under disease conditions, are proposed to contribute to ageing disease progression. While some of the molecules involved have recently been identified, their detailed mechanism of action is still poorly understood.
The project involves a close collaboration between a lab focused on astrocytic function (Bushell) and a lab skilled in understanding molecular mechanisms of gene expression in the nervous system using cutting-edge spatial biology microscopy methods (Davis). The project will test the hypothesis that induction of reactive astrocytes is regulated by the spatial and temporal expression of specific astrocytic mRNA and protein, with these contributing to the known astrocytic role in ageing and disease.
Undertaking this project will expose you to cutting edge techniques to examine an area of intense research focus, the role of astrocytes in ageing and disease. Developing these research skills, alongside the transferable skills you will develop as part of the NWB-DTP cohort, will ultimately help you become a balanced and highly skilled researcher that will be prepared for future roles within academia and other sectors.