How Does Mitochondrial Complex IV Regulate the Rate of Ageing?
Supervisors:
Alberto Sanz, School of Molecular Biosciences,University of Glasgow
Gail McConnell, University of Strathclyde
Summary:
Do you want to help uncover how mitochondria shape ageing and lifespan?
This PhD project offers a unique opportunity to investigate how mitochondrial Complex IV (CIV) influence tissue differentiation and longevity. You will work at the forefront of ageing research using Drosophila melanogaster, a powerful genetic model, to uncover when and where mitochondrial function is essential for healthy ageing.
A highlight of this project is hands-on training in Mesolens imaging technology—a groundbreaking, high-resolution optical system capable of capturing entire tissues in 3D at sub-cellular detail. You will gain expertise in advanced imaging and quantitative structural analysis to assess how tissues develop and change throughout the lifespan.
You will also develop skills in molecular biology, genetics, bioinformatics, and functional phenotyping, integrating cutting-edge techniques to address fundamental questions in mitochondrial biology. Alongside research, you will receive professional development training in scientific writing, grant proposal preparation, project management, and communication skills.
If you are a motivated and ambitious student looking for a challenging, rewarding, and career-defining research experience, this project offers the tools, mentorship, and scientific environment to make a significant contribution to the biology of ageing.