Engineering the cellular microenvironment
Manuel Salmeron-Sanchez (University of Glasgow)
Thursday 1st February, 2018 14:00-15:00 311B Mathematics and Statistics Building
(Lunch with the speaker will be at One A The Square, leaving from the school front foyer at 12.45.)
Cells reside within the extraellular matrix (ECM), a complex 3D mesh of proteins and other macromolecules that provide anchorage support for cells but also instruct them with relevant signals that trigger different processes, such as cell migration and (stem) cell differentiation. During this talk, we will show examples of how different physical properties of the ECM play a key role in controlling cell behaviour, such as the viscoelastic properties and topography of the ECM. Also, we will discuss the importance of the presentation of growth factors – which are important signalling molecules that control cell development and hence regeneration – tethered to the ECM, and how to recapitulate these aspects of the natural ECM by designing materials with applications in cell engineering and regenerative medicine.