Evaluation of Variations in the In Vivo Mechanics of the Human Right Ventricle through Shape Analysis Based Strategies

Prof. John C Brigham (Durham University)

Thursday 21st September, 2017 14:00-15:00 311B Mathematics and Statistics Building


(Lunch with the speaker will be at One A The Square, leaving from the school front foyer at 12.45.)

Right ventricular (RV) function is thought to be a powerful factor in the prognosis and pathophysiology of pulmonary hypertension (PH) and congestive heart failure. However, the current knowledge of the RV’s adaptation and remodeling process in response to disease is still not entirely able to provide sufficient insights to guide effective treatments and, in particular, to prevent progression of RV failure once it ensues. Chief among the impediments to better understanding the RV is its complex three-dimensional (3D) shape in which it is wrapped around the conical left ventricle with inflow in a completely different plane from outflow.

This talk will present recent efforts to quantify mechanical changes in the RV that can be obtained from basic cardiac imaging data (e.g., standard CT or MR) and are linked to PH-related functional changes. First, a statistical shape analysis approach will be discussed that examines the potential link between the 3D RV endocardial surface shape and PH. A computational approach will be presented that is capable of consistently extracting kinematic features of the human RV, and a feasibility study will be shown to demonstrate the classification capability for patients with/without PH. Then, preliminary efforts will be discussed for an approach to utilize RV shape along with pressure measurements to estimate RV wall stiffness.

Biosketch: John Brigham received a BE from Vanderbilt University and a MS and PhD from Cornell University. Following his PhD in 2008 he joined the University of Pittsburgh as an Assistant Professor, and was later promoted to Associate Professor in the Department of Civil and Environmental Engineering, with a secondary appointment in the Department of Bioengineering. John joined the School of Engineering and Computing Sciences at Durham University as an Associate Professor in Applied Mechanics in 2016. Focusing on computational mechanics and inverse problems, Dr. Brigham’s research group is actively involved in a number of diverse projects, including kinematic analysis of the heart for improved diagnosis of cardiovascular disease, novel design concepts and optimal design strategies for smart material morphing structures, and efficient and accurate quantitative nondestructive evaluation algorithms.

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