Mathematical and computational multiscale modelling of cancer mechano-biology
Dr Vasileios Vavourakis
Thursday 8th December, 2016 14:00-15:00 Maths 515
Cancer research has focused mainly on the identification and characterisation of the genetic and molecular properties of cells, although a comprehensive mechanistic view of cancer therapy remains elusive. To fill this gap, mathematical & computational (in-silico) models have emerged to aid biological experiments, make quantitative and testable predictions of cancer evolution, thus, enabling to theoretically investigate dynamic changes of the tumour–host microenvironment and the heterogeneous tumour-cell genetics and proteomics.
In my talk, I will present two novel in-silico modelling methods of cancer mechano-biology. The developed three-dimensional multiscale models have been formulated to encompass cancer growth, tumour-induced angiogenesis, and the tumour—host tissue microstructure biomechanics. The in-silico models have validated against in-vivo data on collagen microstructure, vascular density and hierarchy, interstitial fluid pressure and solid stresses from murine mammary carcinomas, specifically focusing on the role of mechanical signals in recapitulating in-vivo measurements.