Multiscale Tissue Mechanics: from Microstructure to Pathophysiology
Dr. Yuhang Chen (Heriot-Watt University)
Thursday 3rd March, 2016 14:00-15:00 Maths 203
Unlike the classical biomechanics and cell mechanics, instead of focusing on either system or cell/sub-cellular behaviours, tissue mechanics considers interaction between them at meso-scale which bridges our understanding in human pathophysiology at multiple length scales. One notable challenge in tissue mechanics is ‘how apparent mechanical behaviour observed at higher length scale roots from lower scale, and vice versa, and how this can be quantified and utilised for clinical use’. In our group we focus on tissue microstructure as an intermediate player and attempt to answer this question using multiscale approaches. In this talk, some questions with significant clinical relevance are attempted, including enhanced clinical diagnostics for bone by nonlinear mechanics, quantitative diagnostics of cancer in soft tissue (e.g. prostate) as well as patient-specific predictive modelling for drug delivery.