Aortic flow and drug delivery in solid tumour

Xiao Yun Xu (Imperial College London)

Thursday 14th June, 2012 14:00-15:00 Maths & Stats Bldg, LT 325


This talk will address two different research topics: (1) our recent work and interests in analysis of flow in normal and diseased aortas (e.g. dissected aorta, and aorta after valve root replacement or valve intervention); (2) a system-based model of drug transport in solid tumours and drug uptake by tumour cells. In the first part, examples of patient-specific models of type B aortic dissection will be presented1, as well as our recent work on assessment of the aortic root after valve replacement procedures[2,3]. The second part of the talk will be focused on description of a new mathematical model that couples drug transport in tumour interstitium and cellular responses through apoptosis signalling[4,5]. The effects of drug resistance and drug infusion modes will also be discussed. ===== References 1. Cheng Z, Tan FPP, Riga CV, Bicknell CD, Hamady MS, Gibbs RGJ, Wood NB, Xu XY. Analysis of flow patterns in a patient-specific aortic dissection model. ASME J Biomech Eng 2010. 132: 051007-1-9. 2. Tan FPP, Xu XY, Torii R, Wood NB, Delahunty N, Mullen M, Moat N, Mohiaddin R. Comparison of aortic flow patterns before and after transcatheter aortic valve implantation. Cardiovascular Eng. & Technology 2012, 3:123-135. 3. Torii R, El-Hamamsy I, Donya M, V Babu-Narayan S, Ibrahim M, Kilner PJ, Mohiaddin RH, Xu XY, Yacoub MH. Integrated morphologic and functional assessment of the aortic root after different tissue valve replacement procedures. J Thorac Cardiolvasc Surg 2012, doi:10.1016/j.jtcvs.2011.12.034. 4. Liu C, Krishnan J, Stebbing J, Xu XY. Use of mathematical models to understand anticancer drug delivery and its effect on solid tumors. Pharmacogenomics 2011, 12:1337-1348. 5. Liu C, Krishnan J, Xu XY. A system-based mathematical modelling framework for investigating the effect of drugs on solid tumours. Theoretical Biology and Medical Modelling 2011, 8:45, doi:10.1185/1742-4682-8-45. ==== Biosketch: Xiao Yun Xu is a Professor of Biofluid Mechanics and Director of Postgraduate Studies in the Department of Chemical Engineering at Imperial College London. She joined the Department of Chemical Engineering at Imperial College in 1998 as a Lecturer, and was promoted to full Professor in 2009. She received her BSc and MSc degrees in Thermo-Fluids Engineering from Dalian University of Technology in China, and her Ph.D degree (1992) in Mechanical Engineering from the City University, London, under the supervision of Professor Michael Collins. Her research interests include biomedical engineering and bioprocessing, with a special focus on transport processes in biological and physiological systems. Examples of her current research are: image-based analysis of cardiovascular fluid mechanics and mass transport, controlled release in gastrointestinal tract, nanoparticle-mediated drug delivery in cancer and thrombolytic therapies, and solid-liquid mixing in bioreactors with simultaneous mass transfer. She has published over 90 peer-reviewed journal papers, and supervised 34 PhD students (21 have completed successfully). In 2009, she received the Imperial College Rector’s Award for Excellence in Research Supervision for her exceptional contributions in providing a supportive learning environment for postgraduate research students.

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