To correlate genotype to phenotype of cardiac arrhythmias - a mathematical approach

Henggui Zhang (University of Manchester)

Thursday 23rd April, 2009 14:00-15:00 Mathematics Building, 325


Recent progress in molecular cardiology has identified various genes coding ion channels present in cardiac cells, which are responsible for generating electrical activities in the heart. However, it is still challenging to identify the functional role of these genes, especially their defects or mutations on genesis of cardiac arrhythmias. Biophysically detailed mathematical models of the heart provide a powerful tool to tackle this challenge. In this talk, I shall report our recent works on mathematical modelling of cardiac electrical activities. I shall illustrate how mathematical modelling can help to underpin the pro-arrhythmic effects of some gene mutations associated with patients with short QT syndrome and atrial fibrillation.

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