Modelling and Validating Device-Induced Thrombosis and Thromboembolization

Keefe B. Manning (The Pennsylvania State University, USA)

Tuesday 13th December, 2022 15:00-16:00 ROOM 110 and ZOOM (ID: 856 3920 6067)


Thrombosis remains a significant clinical issue manifesting in heart attacks and strokes. However, the challenges extend to the success of cardiovascular devices. Given the complex process associated with thrombosis, developing an accurate computational model is challenging particularly validating the model that encompasses a range of flow and surface interactions and occurs at different temporal and spatial scales. Leveraging canonical experiments that acquire a breadth of data will be crucial to validate the computational model. Furthermore, there are different mathematical approaches that may be used to model thrombosis with some ideally suited for predicting embolization. This presentation will cover the development and experimental validation of the model and ongoing methods that add more complexity and accuracy to the model. Ultimately, the goal of the model is to be sensitive to different material surfaces and respond to low and high shear environments to predict thrombus formation and potential embolization

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