Dr Sean Mcginty

Reader (Biomedical Engineering)
Senior Senate Assessors for Student Conduct (Academic Services) (Academic Services)

telephone: 01413308588
email: Sean.Mcginty@glasgow.ac.uk

Biography

I obtained a BSc in Mathematics & Physics from the University of Strathclyde, before completing a PhD in Applied Mathematics. Following some short postdoctoral positions, I moved into the industry, working in the Renewable Energy Sector, where my role involved forecasting the energy output of wind farms at the pre-construction stage. After two enjoyable years in industry, I returned to academia as Research Associate in the Department of Mathematics & Statistics at the University of Strathclyde. Following this, I became Knowledge Exchange Associate in the Department, with the remit of helping Mathematics & Statistics colleagues to better engage with industry and other stakeholders.

I was appointed Lecturer at University of Glasgow in 2015, within the Division of Biomedical Engineering, where my mathematical modelling research is being applied to problems in biology and health. During this time, I became a Fellow of The Institute of Mathematics & its Applications (FIMA designation) and a Chartered Mathematician (CMath designation).

From 2016-2024, I was the Director of CMALS (Centre for Mathematics applied to the Life Sciences), a Scottish centre whose mission is to promote interdisciplinary research and scholarship in Mathematical Biology.

In 2020 I was promoted to Senior Lecturer and subsequently promoted to Reader the following year in 2021.

From 2019-2021, I served on the EPSRC Mathematical Sciences Strategic Advisory Team (SAT) and I have taken part in several EPSRC Mathematical Sciences Funding Prioritisation Panels. Further afield, I play a role in the strategic development of a number of other organisations related to Mathematical Sciences, including the European Consortium for Mathematics in Industry (ECMI), where I lead a special interest group.

Since 2022, I have been the School lead for Impact Culture and in 2023, I took up a key leadership role as Senior Senate Assessor for Student Conduct.

Research interests

MaCBE: Mathematical and Computational Biomedical Engineering

I lead a group focussed on developing mathematical and computational tools to help understand biological processes, disease and treatment, in collaboration with leading experimental groups, clinical centres and industry. Our present research lies at the interface of computational modelling, healthcare and machine learning/AI. I have expertise in mathematical modelling of biological systems broadly within the application areas of drug discovery and drug delivery.

I am perhaps best known for my mathematical modelling of percutaneous coronary intervention (with stents and balloons) and have recently been recognised for my pioneering work in this area through the award of the Prof Tom Gibson Memorial prize. Highlights include the development of a novel drug-eluting stent in collaboration with industry and the NHS, the first predictive model of in vivo drug-eluting stent performance, as well as the first continuum computational model of restenosis subject to drug delivery from stents. My work in this area has culminated in the recent award of a major EPSRC grant enabling the creation of The EPSRC Centre for Future PCI Planning.

Some other interests include mathematical modelling of sonoporation using liquid-crystalline shelled microbubbles and theoretical modelling of phase separation in amorphous solid dispersions, using principles from thermodynamics and multi-component diffusion. I have expertise in modelling flow and mass transport in a number of biological applications, including cardiovascular medical implant design and optimization, and in the areas of drug delivery and drug discovery, physiological flows and bioreactor cell culture systems.

As well as the development of appropriate numerical methods, an important feature of my work is the use of analytical techniques (e.g. non-dimensionalisation, asymptotics and sensitivity analysis) to provide added value and to simplify the models whilst still capturing the important features.

Recent Highlights

Award of The Professor Tom Gibson Memorial Prize for pineering work in the area of mathematical modleling of PCI procedures and devices
Our paper "Constrained Bayesian optimization with a cardiovascular application" appears in Proceedings of The Royal Society A
Our paper "An intricate interplay between stent drug dose and release rate dictates arterial restenosis" appears in J. Control. Release.
Our paper on drug-coated balloons Mathematical modelling of endovascular drug delivery: Balloons versus stents - ScienceDirect appears in Int. J. Pharma.
Our paper in Nanoscale and Nanoscale Advances features in an Editor's choice collection focussing on recent breakthroughs in nanobiotechnology.
our paper "Biomimetic Nanotherapies: Red Blood Cell Based Core-Shell Structured Nanocomplexes for Atherosclerosis Management" is published in Advanced Science

Professional activities

I am a former member of both the EPSRC Mathematical Sciences Strategic Advisory team (SAT) and the EPSRC Mathematical Sciences Early Career Forum, and a fellow of the Institute of Mathematics and its Applications (FIMA designation). I also hold the CMath designation and am a member of the European Society of Biomechanics.

I am the director of the European Special Interest Group entitled "Implantable Devices and Drug Delivery Systems," which is supported by the European Consortium for Mathematics in Industry (ECMI). Additionally, I recently acted as Guest Editor on the Feb 2016 Annals of Biomedical Engineering Special Issue "Medical Stents: State of the Art and Future Directions".

I am on the Editorial Boards of the Journal of Pharmacy & Pharmacology, Mathematical Biosciences & Engineering and Frontiers in Medical Technology.

Research Impact, Knowledge Exchange and Public Engagement

I have a track record of collaborating with companies and clinicians to ensure that my work remains relevant and is driven by need. In addition, I engage with the general public to inspire the next generation of scientists and to showcase the value of my work. For example, I have given a talk in the Glasgow Pint of Science festival, have produced several images demonstrating the impact of our work, for public exhibition. Morover, In 2024 I organsied a College-wide Images of Impact Competition and Exhibition for display at the EXPLORATHON and Glasgow Doors Open festivals.

PhD Opportunities

I am very keen to hear from excellent students who wish to study for a PhD with me. Enquiries are warmly welcomed, although prospective students should investigate potential funding and/or scholarships (if required) before getting in touch.

Publications

List by: Type | Date

Jump to: 2025 | 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2011 | 2009

Number of items: 81.

2025

Zeng, J. et al. (2025) Biomimetic ginsenoside rb1 and probucol co-assembled nanoparticles for targeted atherosclerosis therapy via inhibition of oxidative stress, inflammation, and lipid deposition. ACS Nano, 19(25), pp. 22968-22987. (doi: 10.1021/acsnano.5c02492) (PMID:40534137)

Marimuthu, Sathish Kumar, Luraghi, Giulia, Maclean, Craig, Brodie, Robbie, Migliavacca, Francesco, McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Hill, Nicholas A. ORCID: https://orcid.org/0000-0003-3079-828X (2025) A three-dimensional computational study of critical pressures of dissection propagation in the aorta. Biomechanics and Modeling in Mechanobiology, (Accepted for Publication)

Renon, Silvia, Ramses, Rafic, Aggarwal, Ankush ORCID: https://orcid.org/0000-0002-1755-8807, Good, Richard and Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2025) Drug coated balloons in percutaneous coronary intervention: how can computational modelling help inform evolving clinical practice? Frontiers in Medical Technology, 7, 1546417. (doi: 10.3389/fmedt.2025.1546417)

Aggarwal, Ankush ORCID: https://orcid.org/0000-0002-1755-8807, Williams, Ross, Rosnel, Claire ORCID: https://orcid.org/0009-0000-0038-4321, Renon, Silvia, Hussain, Jude M., Schmidt, André F., Huang, Shiting, Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and McBride, Andrew ORCID: https://orcid.org/0000-0001-7153-3777 (2025) pyMechT: A Python package for mechanics of soft tissues. Journal of Open Source Software, 10(106), 7490. (doi: 10.21105/joss.07490)

Corti, Anna, Dal Ferro, Lucia, Akyildiz, Ali C., Migliavacca, Francesco, McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Chiastra, Claudio (2025) Plaque heterogeneity influences in-stent restenosis following drug-eluting stent implantation: insights from patient-specific multiscale modelling. Journal of Biomechanics, 179, 112485. (doi: 10.1016/j.jbiomech.2024.112485) (PMID:39736224)

Aggarwal, Ankush ORCID: https://orcid.org/0000-0002-1755-8807, Coccarelli, Alberto and McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2025) Heterogeneity and multi-scale modeling in vascular biomechanics. In: Liao, J. and Wong, J.Y. (eds.) Integration and Bridging of Multiscale Bioengineering Designs and Tissue Biomechanics. Springer Nature: Switzerland. ISBN 9783031817427

2024

Paun, Mihaela, Fensterseifer Schmidt, André, Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Husmeier, Dirk ORCID: https://orcid.org/0000-0003-1673-7413 (2024) Constrained Bayesian optimization with a cardiovascular application. Proceedings of the Royal Society A: Mathematical, Physical and Engineering Sciences, 480(2295), 20230371. (doi: 10.1098/rspa.2023.0371)

Jain, Ankur, Pontrelli, Giuseppe and McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2024) Laplace transform based modeling of drug delivery with reversible drug binding in a multilayer tissue. Pharmaceutical Research, 41(6), pp. 1093-1107. (doi: 10.1007/s11095-024-03711-4) (PMID:38862720)

Ramses, Rafic, Kennedy, Simon ORCID: https://orcid.org/0000-0003-0887-5840, Good, Richard, Oldroyd, Keith G. and Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2024) Performance of drug-coated balloons in coronary and below-the-knee arteries: anatomical, physiological and pathological considerations. Vascular Pharmacology, 155, 107366. (doi: 10.1016/j.vph.2024.107366) (PMID:38479462)

2023

Corti, Anna, McQueen, Alistair, Migliavacca, Francesco, Chiastra, Claudio and McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2023) Investigating the effect of drug release on in-stent restenosis: a hybrid continuum – agent-based modelling approach. Computer Methods and Programs in Biomedicine, 241, 107739. (doi: 10.1016/j.cmpb.2023.107739)

Pontrelli, Giuseppe, Bretti, Gabriella and McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2023) Modelling smart drug release with functionally graded materials. Computers in Biology and Medicine, 164, 107294. (doi: 10.1016/j.compbiomed.2023.107294)

Jain, Ankur, King, David ORCID: https://orcid.org/0009-0000-9613-721X, Pontrelli, Giuseppe and Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2023) Controlling release from encapsulated drug-loaded devices: insights from modeling the dissolution front propagation. Journal of Controlled Release, 360, pp. 225-235. (doi: 10.1016/j.jconrel.2023.06.019) (PMID:37328006)

Hyndman, Lauren, McKee, Sean and McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2023) Solute transport with Michaelis-Menten kinetics for in vitro cell culture. Mathematical Medicine and Biology, 40(1), pp. 49-72. (doi: 10.1093/imammb/dqac014) (PMID:36201433)

Salvi, Swapnil, Jain, Ankur, Pontrelli, Giuseppe and McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2023) Modeling dual drug delivery from eluting stents: the influence of non-linear binding competition and non-uniform drug loading. Pharmaceutical Research, 40(1), pp. 215-230. (doi: 10.1007/s11095-022-03419-3) (PMID:36473984)

2022

Jain, Ankur, Subbarao, Kamesh, McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Pontrelli, Giuseppe (2022) Optimization of initial drug distribution in spherical capsules for personalized release. Pharmaceutical Research, 39(10), pp. 2607-2620. (doi: 10.1007/s11095-022-03359-y) (PMID:36071351)

McQueen, Alistair, Escuer, Javier, Schmidt, André Fensterseifer, Aggarwal, Ankush ORCID: https://orcid.org/0000-0002-1755-8807, Kennedy, Simon ORCID: https://orcid.org/0000-0003-0887-5840, McCormick, Christopher, Oldroyd, Keith and Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2022) An intricate interplay between stent drug dose and release rate dictates arterial restenosis. Journal of Controlled Release, 349, pp. 992-1008. (doi: 10.1016/j.jconrel.2022.07.037) (PMID:35921913)

Paun, L. Mihaela, Schmidt, André Fensterseifer, Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Husmeier, Dirk ORCID: https://orcid.org/0000-0003-1673-7413 (2022) Statistical Inference for Optimisation of Drug Delivery from Stents. In: Proceedings of the 4th International Conference on Statistics: Theory and Applications (ICSTA 22), Prague, Czech Republic, 28-30 July 2022, ISBN 9781990800085 (doi: 10.11159/icsta22.138)

Colombo, Monika, Corti, Anna, Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669, Migliavacca, Francesco and Chiastra, Claudio (2022) Fluid dynamics and mass transport in lower limb vessels: effects on restenosis. In: Becker, Sid, Kuznetsov, Andrey, Pontrelli, Giuseppe, Zhao, Dan and de Monte, Filippo (eds.) Modeling of Mass Transport Processes in Biological Media. Elsevier. ISBN 9780323857406

Escuer, Javier, Fensterseifer Schmidt, André, Peña, Estefanía, Martínez, Miguel A. and McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2022) Mathematical modelling of endovascular drug delivery: balloons versus stents. International Journal of Pharmaceutics, 620, 121742. (doi: 10.1016/j.ijpharm.2022.121742) (PMID:35427751)

Jain, Ankur, McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669, Pontrelli, Giuseppe and Zhou, Long (2022) Theoretical modeling of endovascular drug delivery into a multilayer arterial wall from a drug-coated balloon. International Journal of Heat and Mass Transfer, 187, 122572. (doi: 10.1016/j.ijheatmasstransfer.2022.122572)

Jain, Ankur, Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Pontrelli, Giuseppe (2022) Drug diffusion and release from a bioerodible spherical capsule. International Journal of Pharmaceutics, 616, 121442. (doi: 10.1016/j.ijpharm.2021.121442)

Jain, Ankur, Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669, Pontrelli, Giuseppe and Zhou, Long (2022) Theoretical model for diffusion-reaction based drug delivery from a multilayer spherical capsule. International Journal of Heat and Mass Transfer, 183(Part A), 122072. (doi: 10.1016/j.ijheatmasstransfer.2021.122072)

King, David ORCID: https://orcid.org/0009-0000-9613-721X, McCormick, Christopher and McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2022) How does fluid flow influence drug release from drug filled implants? Pharmaceutical Research, 39(1), pp. 25-40. (doi: 10.1007/s11095-021-03127-4) (PMID:34997423)

2021

Colombo, Monika, Corti, Anna, Berceli, Scott, Migliavacca, Francesco, Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Chiastra, Claudio (2021) 3D modelling of drug-coated balloons for the treatment of calcified superficial femoral arteries. PLoS ONE, 16(10), e0256783. (doi: 10.1371/journal.pone.0256783) (PMID:34634057) (PMCID:PMC8504744)

McQueen, Alistair, Escuer, Javier, Aggarwal, Ankush ORCID: https://orcid.org/0000-0002-1755-8807, Kennedy, Simon ORCID: https://orcid.org/0000-0003-0887-5840, McCormick, Christopher, Oldroyd, Keith and Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2021) Do we really understand how drug eluted from stents modulates arterial healing? International Journal of Pharmaceutics, 601, 120575. (doi: 10.1016/j.ijpharm.2021.120575) (PMID:33845150)

Pontrelli, G., Toniolo, G., McGinty, S. ORCID: https://orcid.org/0000-0002-2428-2669, Peri, D., Succi, S. and Chatgilialoglu, C. (2021) Mathematical modelling of drug delivery from pH-responsive nanocontainers. Computers in Biology and Medicine, 131, 104238. (doi: 10.1016/j.compbiomed.2021.104238)

Mayer Sihombing, Maic Audo Eybi, Safitri, Maharani, Zhou, Tian, Wang, Lu, McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669, Qiu, Juhui and Wang, Guixue (2021) Unexpected role of nonimmune cells: amateur phagocytes. DNA and Cell Biology, 40(2), pp. 157-171. (doi: 10.1089/dna.2020.5647) (PMID:33439750)

Wang, Y. et al. (2021) Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications. Theranostics, 11(1), pp. 164-180. (doi: 10.7150/thno.47841)

Escuer, Javier, Aznar, Irene, McCormick, Christopher, Peña, Estefanía, McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Martínez, Miguel A. (2021) Influence of vessel curvature and plaque composition on drug transport in the arterial wall following drug-eluting stent implantation. Biomechanics and Modeling in Mechanobiology, 20, pp. 767-786. (doi: 10.1007/s10237-020-01415-3) (PMID:33533998)

2020

Escuer, Javier, Cebollero, Martina, Peña, Estefanía, McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Martınez, Miguel A. (2020) How does stent expansion alter drug transport properties of the arterial wall? Journal of the Mechanical Behavior of Biomedical Materials, 104, 103610. (doi: 10.1016/j.jmbbm.2019.103610)

McQueen, Alistair, Kennedy, Simon ORCID: https://orcid.org/0000-0003-0887-5840, McCormick, Chris, Aggarwal, Ankush ORCID: https://orcid.org/0000-0002-1755-8807 and McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2020) Mathematical Modelling of the Effect of Drug on Smooth Muscle Cell Proliferation. Scottish Cardiovascular Forum 2020, 23rd Annual Meeting, Glasgow, UK, 1 Feb 2020.

Wang, Y. et al. (2020) Covalent immobilization of biomolecules on stent materials through mussel adhesive protein coating to form biofunctional films. Materials Science and Engineering C: Materials for Biological Applications, 106, 110187. (doi: 10.1016/j.msec.2019.110187)

Yin, Ying, Wang, Jun, Yang, Meng, Du, Ruolin, Pontrelli, Giuseppe, McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669, Wang, Guixue, Yin, Tieying and Wang, Yazhou (2020) Penetration of the blood-brain barrier and anti-tumor effect of a novel PLGA-lysoGM1/DOX micelles drug delivery system. Nanoscale, 12, pp. 2946-2960. (doi: 10.1039/C9NR08741A) (PMID:31994576)

2019

Liu, Ruoxuan, McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669, Cui, Fangsen, Luo, Xiaoyu ORCID: https://orcid.org/0000-0002-8753-4210 and Liu, Zishun (2019) Modelling and simulation of the expansion of a shape memory polymer stent. Engineering Computations, 36(8), pp. 2726-2746. (doi: 10.1108/EC-10-2018-0462)

Hyndman, Lauren, McKee, Sean, Mottram, Nigel J., Singh, Bhumika, Webb, Steven D. and McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2019) Mathematical modelling of fluid flow and solute transport to define operating parameters for in vitro perfusion cell culture systems. Interface Focus, 10(2), 20190045. (doi: 10.1098/rsfs.2019.0045) (PMID:32194930) (PMCID:PMC7061945)

Escuer, Javier, Martinez, Miguel A., McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Pena, Estefania (2019) Mathematical modelling of the restenosis process after stent implantation. Journal of the Royal Society: Interface, 16(157), 20190313. (doi: 10.1098/rsif.2019.0313) (PMID:31409233)

O’Keeffe, Alec, Hyndman, Lauren, McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669, Riezk, Alaa, Murdan, Sudaxshina and Croft, Simon L. (2019) Development of an in vitro media perfusion model of Leishmania major macrophage infection. PLoS ONE, 14(7), e0219985. (doi: 10.1371/journal.pone.0219985) (PMID:31339931) (PMCID:PMC6656416)

Escuer, Javier, Martinez, Miguel Angel, Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Pena, Estefania (2019) A Computational Mechanobiological Model to Simulate the In-Stent Restenosis Process. 25th Congress of the European Society of Biomechanics (ESB2019), Vienna, Austria, 7-10 July 2019. (Unpublished)

Escuer, Javier, Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669, Pena, Estefania, Martinez, Miguel Angel and Conway, Claire (2019) Coupling Solid Mechanics and Drug Transport in 3D for Drug-Eluting Stent Analysis. 25th Congress of the European Society of Biomechanics (ESB2019), Vienna, Austria, 7-10 July 2019. (Unpublished)

Cowley, James and Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2019) A mathematical model of sonoporation using a liquid-crystalline shelled microbubble. Ultrasonics, 96, pp. 214-219. (doi: 10.1016/j.ultras.2019.01.004) (PMID:30739724)

Meere, Martin, Pontrelli, Giuseppe and McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2019) Modelling phase separation in amorphous solid dispersions. Acta Biomaterialia, 94, pp. 410-424. (doi: 10.1016/j.actbio.2019.06.009) (PMID:31238110)

McKittrick, Craig, McKee, Sean, Kennedy, Simon ORCID: https://orcid.org/0000-0003-0887-5840, Oldroyd, Keith, Wheel, Marcus, Pontrelli, Giuseppe, Dixon, Simon, Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and McCormick, Christopher (2019) Combining mathematical modelling with in vitro experiments to predict in vivo drug-eluting stent performance. Journal of Controlled Release, 303, pp. 151-161. (doi: 10.1016/j.jconrel.2019.03.012) (PMID:30878363)

Vynnycky, Michael, McKee, Sean, Meere, Martin, McCormick, Chris and McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2019) Asymptotic analysis of drug dissolution in two layers having widely differing diffusivities. IMA Journal of Applied Mathematics, 84(3), pp. 533-554. (doi: 10.1093/imamat/hxz002)

Wang, Y. et al. (2019) Biomimetic nanotherapies: red blood cell based core-shell structured nanocomplexes for atherosclerosis management. Advanced Science, 6(12), 1900172. (doi: 10.1002/advs.201900172)

Martinez, Miguel Angel, Escuer, Javier, Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Pena, Estefania (2019) A Continuum-Approach Model to Numerically Simulate the In-Stent Restenosis Process. First Colloquium of the Spanish Theoretical and Applied Mechanics Society (STAMS2019), Madrid, Spain, 28-29 March 2019. (Unpublished)

Tomlinson, Lauren, Hyndman, Lauren, Firman, James W., Bentley, Robert, Kyffin, Jonathan A., Webb, Steven D., McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Sharma, Parveen (2019) In vitro liver zonation of primary rat hepatocytes. Frontiers in Bioengineering and Biotechnology, 7, 17. (doi: 10.3389/fbioe.2019.00017)

2018

Lucena, R.M., Mangiavacchi, N., Pontes, J., Anjos, G. and McGinty, S. ORCID: https://orcid.org/0000-0002-2428-2669 (2018) On the transport through polymer layer and porous arterial wall in drug-eluting stents. Journal of the Brazilian Society of Mechanical Sciences and Engineering, 40(12), 572. (doi: 10.1007/s40430-018-1487-8)

Escuer, Javier, Pena, E., Martinez, M.A. and Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2018) Elucidating the Importance of Drug Dissolution and Specific-binding in a 2D Model of Arterial Drug-eluting Stents. Virtual Physiological Human Conference (VPH2018), Zaragoza, Spain, 5-7 Sept 2018. (Unpublished)

Escuer, Javier, Pena, E., Martinez, M.A. and Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2018) On the Relationship Between Mechanical Deformation and Drug Transport Properties of the Arterial Wall. Modelling and Experiments in Drug Delivery Systems (MEDDS2018), Glasgow, UK, 3-5 Sept 2018. (Unpublished)

Escuer, Javier, Cebollero, Martina, Pena, Estefania, Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Martinez, Miguel Angel (2018) Computational Modelling of the Effect of Mechanical Expansion on Drug Delivery from Endovascular Devices. 8th World Congress of Biomechanics, Dublin, Ireland, 8-12 July 2018. (Unpublished)

Escuer, Javier, Scullion, Bryan, McCormick, Christopher and Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2018) On The Influence of Non-Uniform Binding Site Density in Determining Arterial Drug Distribution Following Stent-Based Delivery. 8th World Congress of Biomechanics, Dublin, Ireland, 8-12 July 2018. (Unpublished)

Du, R. et al. (2018) Design and testing of hydrophobic core/hydrophilic shell nano/micro particles for drug-eluting stent coating. NPG Asia Materials, 10, pp. 642-658. (doi: 10.1038/s41427-018-0064-z)

Vo, Tuoi T.N., Morgan, Sarah, McCormick, Christopher, McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669, McKee, Sean and Meere, Martin (2018) Modelling drug release from polymer-free coronary stents with microporous surfaces. International Journal of Pharmaceutics, 544(2), pp. 392-401. (doi: 10.1016/j.ijpharm.2017.12.007) (PMID:29229513)

Escuer, Javier, Pena, Estefania, Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Martinez, Miguel Angel (2018) Computational Analysis of the Influence of Dissolution-Diffusion and Specific Binding on Drug Transport in the Arterial Wall following Stent-based Delivery. VII Jornada de Jóvenes Investigadores del (I3A), Zaragoza, Spain, 8 June 2018. (Unpublished)

McQueen, Alistair, Parente, Jacquelyn Dawn, Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Moeller, Knut (2018) Parameter search to find ranges of activation and inhibition of wound healing rate in a mathematical model with introduced photobiomodulation. In: Lhotska, Lenka, Sukupova, Lucie, Lacković, Igor and Ibbott, Geoffrey S. (eds.) World Congress on Medical Physics and Biomedical Engineering 2018. Series: IFMBE Proceedings (68/1). Springer: Singapore, pp. 819-822. ISBN 9789811090349 (doi: 10.1007/978-981-10-9035-6_151)

2017

Meere, Martin, Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Pontrelli, Giuseppe (2017) Mathematically Modelling the Dissolution of Solid Dispersions. In: Equadiff 2017 Conference, Bratislava, Slovakia, 24-28 Jul 2017, pp. 341-348. ISBN 9788022747578

McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669, King, David ORCID: https://orcid.org/0009-0000-9613-721X and Pontrelli, Giuseppe (2017) Mathematical modelling of variable porosity coatings for controlled drug release. Medical Engineering and Physics, 45, pp. 51-60. (doi: 10.1016/j.medengphy.2017.04.006) (PMID:28461200)

McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669, Hyndman, Lauren, Mottram, Nigel ORCID: https://orcid.org/0000-0002-7265-0059, McKee, Sean and Webb, Steven (2017) In-silico Characterisation of the Kirkstall QV900 In-Vitro System for Advanced Cell Culture. In: 5 th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017), Pittsburgh, PA, USA, 10-12 April 2017, pp. 1174-1177. ISBN 9780956291448

McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669, McCormick, Christopher, McKittrick, Craig, Kennedy, Simon ORCID: https://orcid.org/0000-0003-0887-5840, Oldroyd, Keith, Wheel, Marcus, Scullion, Brian, Pontrelli, Giuseppe and McKee, Sean (2017) Combining Mathematical Modelling with In-Vitro Experiments to Predict In-Vivo Drug-Eluting Stent Kinetics. In: 5 th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017), Pittsburgh, PA, USA, 10-12 April 2017, pp. 1011-1014. ISBN 9780956291448

McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Pontrelli, Giuseppe (2017) Mathematical Modelling of Variable Porosity Coatings for Dual Drug Delivery. In: 5 th International Conference on Computational and Mathematical Biomedical Engineering (CMBE2017), Pittsburgh, PA, USA, 10-12 April 2017, pp. 184-187. ISBN 9780956291448

2016

King, David ORCID: https://orcid.org/0009-0000-9613-721X and McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2016) Assessing the potential of mathematical modelling in designing drug-releasing orthopaedic implants. Journal of Controlled Release, 239, pp. 49-61. (doi: 10.1016/j.jconrel.2016.08.009) (PMID:27521893)

Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Pontrelli, Giuseppe (2016) On the role of specific drug binding in modelling arterial eluting stents. Journal of Mathematical Chemistry, 54(4), pp. 967-976. (doi: 10.1007/s10910-016-0618-7)

McHugh, Peter, Barakat, Abdul and Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2016) Medical Stents: State of the Art and Future Directions [Guest Editors]. Annals of Biomedical Engineering, 44(2), pp. 274-275. (doi: 10.1007/s10439-015-1526-x) (PMID:26678496)

McKittrick, C.M., Kennedy, S. ORCID: https://orcid.org/0000-0003-0887-5840, Oldroyd, K.G., Mcginty, S. ORCID: https://orcid.org/0000-0002-2428-2669 and McCormick, C. (2016) Modelling the impact of atherosclerosis on drug release and distribution from coronary stents. Annals of Biomedical Engineering, 44(2), pp. 477-487. (doi: 10.1007/s10439-015-1456-7) (PMID:26384667) (PMCID:PMC4764635)

Sengers, Bram G., McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669, Nouri, Fatma Z., Argungu, Maryam, Hawkins, Emma, Hadji, Aymen, Weber, Andrew, Taylor, Adam and Sepp, Armin (2016) Modelling bispecific monoclonal antibody interaction with two cell membrane targets indicates the importance of surface diffusion. mAbs, 8(5), pp. 905-916. (doi: 10.1080/19420862.2016.1178437) (PMID:27097222) (PMCID:PMC4968105)

2015

Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Pontrelli, Giuseppe (2015) A general model of coupled drug release and tissue absorption for drug delivery devices. Journal of Controlled Release, 217, pp. 327-336. (doi: 10.1016/j.jconrel.2015.09.025) (PMID:26390809)

Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669, Wheel, Marcus, McKee, Sean and McCormick, Christopher (2015) Does anisotropy promote spatial uniformity of stent-delivered drug distribution in arterial tissue? International Journal of Heat and Mass Transfer, 90, pp. 266-279. (doi: 10.1016/j.ijheatmasstransfer.2015.06.061)

Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669, McKee, Sean, McCormick, Christopher and Wheel, Marcus (2015) Release mechanism and parameter estimation in drug-eluting stent systems: analytical solutions of drug release and tissue transport. Mathematical Medicine and Biology, 32(2), pp. 163-186. (doi: 10.1093/imammb/dqt025) (PMID:24463960) (PMCID:PMC4463185)

Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669, Vo, Tuoi T.N., Meere, Martin, McKee, Sean and McCormick, Christopher (2015) Some design considerations for polymer-free drug-eluting stents: a mathematical approach. Acta Biomaterialia, 18, pp. 213-225. (doi: 10.1016/j.actbio.2015.02.006) (PMID:25712386)

Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Pontrelli, Giuseppe (2015) On the influence of solid–liquid mass transfer in the modelling of drug release from stents. Journal of Coupled Systems and Multiscale Dynamics, 3(1), pp. 47-56. (doi: 10.1166/jcsmd.2015.1064)

McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and McKee, Sean (2015) Blade shape of a Troposkein type of vertical axis wind turbine. Mathematical Spectrum, 47(2), pp. 51-60.

McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Pontrelli, Giuseppe (2015) A 1D Mechanistic Model Can Predict Duration of In-Vivo Drug Release from Drug-Eluting Stents. In: 4th International Conference on Computational & Mathematical Biomedical Engineering, Paris, France, 29 June - 1 July 2015, pp. 658-661. ISBN 9780956291431

McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669, Wheel, Marcus, McKee, Sean, McCormick, Christopher, McKittrick, Craig, Kennedy, Simon ORCID: https://orcid.org/0000-0003-0887-5840 and Oldroyd, Keith (2015) Can Anisotropy Enhance the Spatial Uniformity of Drug Distribution in Biological Tissue? In: 4th International Conference on Computational & Mathematical Biomedical Engineering, Paris, France, 29 June - 1 July 2015, pp. 194-197. ISBN 9780956291431

McKee, S. and Mcginty, S. ORCID: https://orcid.org/0000-0002-2428-2669 (2015) Stents, blood flow and pregnancy: mathematical modelling in the raw. In: Bissell, John J., Caiado, Camila C. S., Curtis, Sarah, Goldstein, Michael and Straughan, Brian (eds.) Tipping Points: Modelling Social Problems and Health Tipping Points: Modelling Social Problems and Health. Series: Wiley series in computational and quantitative social science. John Wiley & Sons Ltd., pp. 95-112. ISBN 9781118752753 (doi: 10.1002/9781118992005.ch6)

2014

Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2014) A decade of modelling drug release from arterial stents. Mathematical Biosciences, 257, pp. 80-90. (doi: 10.1016/j.mbs.2014.06.016)

Pontrelli, Giuseppe and McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2014) Drug Delivery in Biological Tissues: A Two-Layer Reaction-Diffusion-Convection Model. In: 18th European Conference on Mathematics for Industry 2014, Taormina, Italy, 9-13 June 2014,

2013

McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669, McCormick, Christopher, McKee, Sean, Wheel, Marcus, Kennedy, Simon and Oldroyd, Keith G. (2013) Simulating Drug-Eluting Stents: Progress Made and the Way Forward. In: Special Session on Modelling and Simulation in Biology and Medicine (BIOMED 2013), Reykajvik, Iceland, 29-31 July 2013, pp. 664-671.

Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669, McKee, Sean, Wadsworth, Roger M. and McCormick, Christopher (2013) Modeling arterial wall drug concentrations following the insertion of a drug-eluting stent. SIAM Journal on Applied Mathematics, 73(6), pp. 2004-2028. (doi: 10.1137/12089065X)

2011

McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Mckee, Sean (2011) A comment on pulsatile pipe flow. Applied Mathematical and Computational Sciences, 3(2), pp. 217-225.

McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669, McKee, Sean, Wadsworth, Roger M. and McCormick, Christopher (2011) Modelling drug-eluting stents. Mathematical Medicine and Biology, 28(1), pp. 1-29. (doi: 10.1093/imammb/dqq003)

2009

McGinty, S. ORCID: https://orcid.org/0000-0002-2428-2669, McKee, S. and McDermott, R. (2009) Analytic solutions of Newtonian and non-Newtonian pipe flows subject to a general time-dependent pressure gradient. Journal of Non-Newtonian Fluid Mechanics, 162(1-3), pp. 54-77. (doi: 10.1016/j.jnnfm.2009.05.007)

This list was generated on Fri Jul 18 09:04:40 2025 BST.

Jump to: Articles | Book Sections | Conference or Workshop Item | Conference Proceedings

Number of items: 81.

Articles

Wang, Y. et al. (2021) Macrophage membrane functionalized biomimetic nanoparticles for targeted anti-atherosclerosis applications. Theranostics, 11(1), pp. 164-180. (doi: 10.7150/thno.47841)

McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and McKee, Sean (2015) Blade shape of a Troposkein type of vertical axis wind turbine. Mathematical Spectrum, 47(2), pp. 51-60.

Mcginty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 (2014) A decade of modelling drug release from arterial stents. Mathematical Biosciences, 257, pp. 80-90. (doi: 10.1016/j.mbs.2014.06.016)

McGinty, Sean ORCID: https://orcid.org/0000-0002-2428-2669 and Mckee, Sean (2011) A comment on pulsatile pipe flow. Applied Mathematical and Computational Sciences, 3(2), pp. 217-225.

Book Sections

Conference or Workshop Item

Conference Proceedings

This list was generated on Fri Jul 18 09:04:40 2025 BST.

Grants

• EPSRC (2024-2028), Centre for Future PCI Planning, EP/Z531182/1 (PI)

• Biosensors International (2021-2023), In silico assessment of DCB technology (PI)

• EPSRC (2020-2024), The SofTMech Statistical Emulation and Translation Hub (SofTMechSET), EP/T017899/1 (CI)

• EPSRC (2019-2023), SofTMech with MIT and POLIMI (SofTMechMP), EP/S030875/1 (CI)

• Lord Kelvin Adam Smith Studentship (2018-2022) (PI)

• The Carnegie Trust (2018), Mathematical modelling of sonoporation for a liquid crystal shell microbubble, (PI)

• Royal Society Newton Mobility Grant (2018-2020), Towards Next Generation Stenting - The Evaluation and Study On The Mechanical Behaviour of Novel Shape Memory Polymer Stents, (CI)

• EPSRC GCF ISF (2016-2017), Improved modelling for the design of optimized next generation drug-eluting stents, (PI)

• The Dr Hadwen Trust (2016), In-silico characterisation of the Kirkstall QV900 in-vitro system for advanced cell culture, (PI)

• NHS Greater Glasgow & Clyde Research Endowment Fund (2016-2017), Investigating the potential of mathematical modelling for the analysis of congenital heart disease, (PI)

• EU COST Action TD1409 MI-NET (2015-2016), Mathematical modelling training week with industry, (PI)

• EPSRC IAA (2016), Understanding the potential benefits of using bispecific versus monospecific antibodies (with Glaxosmithkline), (PI)

• EPSRC IAA (2016), Modelling drug penetration in 3D hepatocyte spheroids (with AstraZeneca), (PI)

• EPSRC POEMS Network Funding (2015), Computational modelling in healthcare: Making confident predictions in a world of error and uncertainty, (PI)

• EPSRC IAA New Company Engagement (2014-2015), Simulating complex flow and absorption in quasi-vivo cell culture systems (with Kirkstall Ltd.), (PI)

• Royal Society (2014-2016), Modelling drug release from polymer-free drug-eluting stents, (PI)

Supervision

PhD Students (as primary supervisor)

Marcia McSwegan
Rafic Ramses
Silvia Renon
Sarah Eccles
Orla Conlon
Lucia Dal Ferro

PhD Students (as joint supervisor)

Parna Mandal (Jointly supervised with Prof Nigel Mottram)
Sathish Kumar (Jointly supervised with Prof Nick Hill)
Shitang Huang (Jointly supervised with Dr Ankush Aggarwal)

Former students and PDRAs

Dr Danyang Wang
Dr Rachel Lucena
Bryan Scullion
Dr James Cowley
Dr David King
Dr Lauren Hyndman
Scott Black
Dr Alistair McQueen
Dr Andre Fensterseifer Schmidt

Huang, Shiting
Computational modelling of changes in the right ventricular function following lung resection
Renon, Silvia
A novel hybrid DCB + DES strategy for the treatment of coronary artery disease

Teaching

Current Courses

ENG1063: Engineering Mathematics 1
ENG4085: Integrated Systems Design Project 4 (ISDP4)
ENG2098: Engineering in Biology 2

James Watt School of Engineering

Dr Sean Mcginty

Biography

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Dr Sean Mcginty

Biography

Research interests

Research Impact, Knowledge Exchange and Public Engagement

PhD Opportunities

Publications

2025

2024

2023

2022

2021

2020

2019

2018

2017

2016

2015

2014

2013

2011

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Articles

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PhD Students (as primary supervisor)

PhD Students (as joint supervisor)

Former students and PDRAs

Teaching

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Additional information