Miss Saumya Sharma
- Affiliate (School of Chemistry)
email:
Saumya.Sharma@glasgow.ac.uk
Keltic Pharma Therapeutics, The ARC, University of Glasgow, Glasgow, G11 6EW
Publications
2026
Janha, Omar, Olaniyan, Niniola, Diam, Go Ka, Sharma, Saumya, Beraldi, Dario, Jamieson, Andrew G. 
ORCID: https://orcid.org/0000-0003-1726-7353, Bozdech, Zbynek, Tobin, Andrew B. ORCID: https://orcid.org/0000-0002-1807-3123 and Modrzynska, Katarzyna ORCID: https://orcid.org/0000-0002-0877-3564
(2026)
Inhibition of PfCLK3 interferes with malaria parasite RNA splicing and explains the mechanism of action of a new class of antimalarial candidates.
Antimicrobial Agents and Chemotherapy,
(doi: 10.1128/aac.01561-25)
(Early Online Publication)
Brettell, Skye B., Fuentes-Guerra Bustos, Carla, Sharma, Saumya, Cann, Gillian, Carruthers, Lauren V. ORCID: https://orcid.org/0000-0003-4346-2283, Begen, Abbey, Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519, Clarke, David J., Tobin, Andrew B. ORCID: https://orcid.org/0000-0002-1807-3123 and Jamieson, Andrew ORCID: https://orcid.org/0000-0003-1726-7353
(2026)
Shaping antimalarials: a geometry-first approach to PfCLK3 covalent inhibitors.
Journal of Medicinal Chemistry, 69(3),
pp. 3378-3395.
(doi: 10.1021/acs.jmedchem.5c03342)
(PMID:41618901)
(PMCID:PMC12910650)
2025
Brettell, Skye B., Cann, Gillian, Begen, Abbey, Sharma, Saumya, Mahindra, Amit, Carruthers, Lauren V. ORCID: https://orcid.org/0000-0003-4346-2283, Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519, Clarke, David J., Tobin, Andrew B. ORCID: https://orcid.org/0000-0002-1807-3123 and Jamieson, Andrew G. ORCID: https://orcid.org/0000-0003-1726-7353
(2025)
Lysine targeting covalent inhibitors of malarial kinase PfCLK3.
RSC Medicinal Chemistry, 16(8),
pp. 3530-3540.
(doi: 10.1039/d5md00335k)
(PMID:40521344)
(PMCID:PMC12164071)
2024
Brettell, S. B. et al. (2024) Targeting PfCLK3 with covalent inhibitors: a novel strategy for malaria treatment. Journal of Medicinal Chemistry, 67(21), pp. 18895-18910. (doi: 10.1021/acs.jmedchem.4c01300) (PMID:39441986) (PMCID:PMC11571108)
Articles
Janha, Omar, Olaniyan, Niniola, Diam, Go Ka, Sharma, Saumya, Beraldi, Dario, Jamieson, Andrew G. ORCID: https://orcid.org/0000-0003-1726-7353, Bozdech, Zbynek, Tobin, Andrew B. ORCID: https://orcid.org/0000-0002-1807-3123 and Modrzynska, Katarzyna ORCID: https://orcid.org/0000-0002-0877-3564
(2026)
Inhibition of PfCLK3 interferes with malaria parasite RNA splicing and explains the mechanism of action of a new class of antimalarial candidates.
Antimicrobial Agents and Chemotherapy,
(doi: 10.1128/aac.01561-25)
(Early Online Publication)
Brettell, Skye B., Fuentes-Guerra Bustos, Carla, Sharma, Saumya, Cann, Gillian, Carruthers, Lauren V. ORCID: https://orcid.org/0000-0003-4346-2283, Begen, Abbey, Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519, Clarke, David J., Tobin, Andrew B. ORCID: https://orcid.org/0000-0002-1807-3123 and Jamieson, Andrew ORCID: https://orcid.org/0000-0003-1726-7353
(2026)
Shaping antimalarials: a geometry-first approach to PfCLK3 covalent inhibitors.
Journal of Medicinal Chemistry, 69(3),
pp. 3378-3395.
(doi: 10.1021/acs.jmedchem.5c03342)
(PMID:41618901)
(PMCID:PMC12910650)
Brettell, Skye B., Cann, Gillian, Begen, Abbey, Sharma, Saumya, Mahindra, Amit, Carruthers, Lauren V. ORCID: https://orcid.org/0000-0003-4346-2283, Milligan, Graeme ORCID: https://orcid.org/0000-0002-6946-3519, Clarke, David J., Tobin, Andrew B. ORCID: https://orcid.org/0000-0002-1807-3123 and Jamieson, Andrew G. ORCID: https://orcid.org/0000-0003-1726-7353
(2025)
Lysine targeting covalent inhibitors of malarial kinase PfCLK3.
RSC Medicinal Chemistry, 16(8),
pp. 3530-3540.
(doi: 10.1039/d5md00335k)
(PMID:40521344)
(PMCID:PMC12164071)
Brettell, S. B. et al. (2024) Targeting PfCLK3 with covalent inhibitors: a novel strategy for malaria treatment. Journal of Medicinal Chemistry, 67(21), pp. 18895-18910. (doi: 10.1021/acs.jmedchem.4c01300) (PMID:39441986) (PMCID:PMC11571108)