Dr Will Fuller

  • Reader (Institute of Cardiovascular & Medical Sciences)

Biography

Having completed undergraduate and postgraduate degrees in pharmacology at the University of Cambridge, Dr Will Fuller undertook 8 years of postdoctoral training in the Cardiovascular Division at King’s College London before moving to Dundee in 2006 to establish his own research laboratory. Will transferred his research programme to ICAMS in 2017.


Research interests

The research theme in my laboratory is the organisation and regulation of cardiac membrane proteins and microdomains in health and disease. We employ a variety of subcellular fractionation, imaging, affinity purification, biochemical and cell and organ physiological techniques to investigate molecular, macromolecular, whole cell and whole organ behaviours. Using these approaches we make fundamental observations into the molecular physiology of ion transporters and their regulators in order to better understand both physiological control of cardiac function, and how these relationships can be targeted to ameliorate dysfunction. Our long-term objective is the translation of basic molecular bioscience into therapeutic strategies for cardiovascular diseases.

Current principal research projects are:

• Regulation of the Na pump by phosphorylation and palmitoylation of its regulatory and catalytic subunits.
• The Na pump as a therapeutic target in cardiac hypertrophy and failure.
• Regulation of ventricular sodium calcium exchanger and L-type Ca channels by palmitoylation.
• Regulation of HCN4 in the sino atrial node by palmitoylation.
• Protection of the ventricular myocardium from ischemic injury by activators of the Nrf2 pathway.
• Substrate recognition by and regulation of the zDHHC palmitoyl acyl transferase enzymes in in health and disease.

Committee Membership:
British Heart Foundation Project Grants Committee, 2014-2018

Membership of Professional Organisations:
Biochemical Society
British Society for Cardiovascular Research
International Society for Heart Research
Scottish Cardiovascular Forum (Committee Member)

Invited Speaker (international conference invitations):
2017 Specifically targeting DHHC-substrate interactions for therapeutic gain in the heart. FASEB Science Research Conference “Protein Lipidation: Enzymology, Signaling and Therapeutics”, Vermont, USA.

2016 Unpicking the workings of the cell surface acyl transferase DHHC5. Biochemical Society Focused Meeting Protein S-palmitoylation: from Mechanism to Application, Oxford.

2016 Dynamic molecular interactions in caveolae at the Joint Meeting of the American Physiological Society and the Physiological Society of the UK and Ireland, Dublin, Ireland.

2015 S-palmitoylation and regulation of NCX1 at quinquennial International Conference on Sodium/Calcium Exchange, Jerusalem, Israel.

2015  Regulation of cardiac sodium pump by palmitoylation, FASEB Science Research Conference “Protein Lipidation, Signaling, and Membrane Domains”, Vermont, USA

2014 Substrate recognition by the acyl transferase DHHC5 at Biochemical Society Focused Meeting “Protein acylation: From mechanism to drug discovery”, University of Edinburgh, UK

2014 A human PLM variant (that predisposes to cardiovascular disease?) at 11th International Symposium on FXYD Proteins in Health and Disease, Aarhus, Denmark

2014 Regulation of the sodium pump in excitable tissue by phospholemman. Plenary Lecture at 14th P-type ATPase meeting, The Netherlands.

2013 Palmitoylation and the control of cardiac ion transporters in Symposium P222, Physiology of Protein Palmitoylation, IUPS 2013.


Grants

Grants and Awards listed are those received whilst working with the University of Glasgow.

  • Palmitoylation of the L-Type Ca Channel Pore-Forming Subunit
    British Heart Foundation
    2018 - 2021
     
  • Small molecules activating Nrf2 as a therapeutic approach to prevent cardiac ischemiareperfusion
    British Heart Foundation
    2018 - 2019
     
  • The Na/K ATPase in cardiovascular health and disease
    British Heart Foundation
    2017 - 2021
     

Publications

List by: Type | Date

Jump to: 2018 | 2017 | 2015 | 2014 | 2013 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000
Number of items: 36.

2018

Howie, J., Wypijewski, K. J., Plain, F., Tulloch, L. B., Fraser, N. J. and Fuller, W. (2018) Greasing the wheels or a spanner in the works? Regulation of the cardiac sodium pump by palmitoylation. Critical Reviews in Biochemistry and Molecular Biology, 53(2), pp. 175-191. (doi:10.1080/10409238.2018.1432560) (PMID:29424237)

2017

Logie, L. et al. (2017) Rab-GTPase binding effector protein 2 (RABEP2) is a primed substrate for Glycogen Synthase kinase-3 (GSK3). Scientific Reports, 7(1), 17682. (doi:10.1038/s41598-017-17087-6) (PMID:29247183) (PMCID:PMC5732219)

Petrushanko, I. Y. et al. (2017) Cysteine residues 244 and 458–459 within the catalytic subunit of Na,K-ATPase control the enzyme's hydrolytic and signaling function under hypoxic conditions. Redox Biology, 13, pp. 310-319. (doi:10.1016/j.redox.2017.05.021) (PMID:28601781) (PMCID:PMC5470536)

Plain, F., Congreve, S. D., Yee, R. S. Z., Kennedy, J., Howie, J., Kuo, C.-W., Fraser, N. J. and Fuller, W. (2017) An amphipathic α-helix directs palmitoylation of the large intracellular loop of the sodium/calcium exchanger. Journal of Biological Chemistry, 292(25), pp. 10745-10752. (doi:10.1074/jbc.M116.773945) (PMID:28432123) (PMCID:PMC5481580)

Hurst, C. H., Turnbull, D., Plain, F., Fuller, W. and Hemsley, P. A. (2017) Maleimide scavenging enhances determination of protein S-palmitoylation state in acyl-exchange methods. BioTechniques, 62(2), pp. 69-75. (doi:10.2144/000114516) (PMID:28193150) (PMCID:PMC5400063)

Plain, F., Turnbull, D., Fraser, N. J. and Fuller, W. (2017) Understanding the rules governing NCX1 palmitoylation. Channels, 11(5), pp. 377-379. (doi:10.1080/19336950.2017.1342501) (PMID:28617626)

2015

Reilly, L., Howie, J., Wypijewski, K., Ashford, M. L. J., Hilgemann, D. W. and Fuller, W. (2015) Palmitoylation of the Na/Ca exchanger cytoplasmic loop controls its inactivation and internalization during stress signaling. FASEB Journal, 29(11), pp. 4532-4543. (doi:10.1096/fj.15-276493) (PMID:26174834) (PMCID:PMC4608915)

Eykyn, T. R., Aksentijević, D., Aughton, K. L., Southworth, R., Fuller, W. and Shattock, M. J. (2015) Multiple quantum filtered 23Na NMR in the Langendorff perfused mouse heart: Ratio of triple/double quantum filtered signals correlates with [Na]i. Journal of Molecular and Cellular Cardiology, 86, pp. 95-101. (doi:10.1016/j.yjmcc.2015.07.009) (PMID:26196304) (PMCID:pmc4564289)

Wypijewski, K. J., Tinti, M., Chen, W., Lamont, D., Ashford, M. L. J., Calaghan, S. C. and Fuller, W. (2015) Identification of caveolar resident proteins in ventricular myocytes using a quantitative proteomic approach: dynamic changes in caveolar composition following adrenoceptor activation. Molecular and Cellular Proteomics, 14(3), pp. 596-608. (doi:10.1074/mcp.M114.038570) (PMID:25561500) (PMCID:PMC4349980)

2014

Howie, J. et al. (2014) Substrate recognition by the cell surface palmitoyl transferase DHHC5. Proceedings of the National Academy of Sciences of the United States of America, 111(49), pp. 17534-17539. (doi:10.1073/pnas.1413627111) (PMID:25422474) (PMCID:PMC4267385)

Boguslavskyi, A., Pavlovic, D., Aughton, K., Clark, J. E., Howie, J., Fuller, W. and Shattock, M. J. (2014) Cardiac hypertrophy in mice expressing unphosphorylatable phospholemman. Cardiovascular Research, 104(1), pp. 72-82. (doi:10.1093/cvr/cvu182) (PMID:25103111) (PMCID:PMC4174889)

2013

Pavlovic, D., Fuller, W. and Shattock, M. J. (2013) Novel regulation of cardiac Na pump via phospholemman. Journal of Molecular and Cellular Cardiology, 61, pp. 83-93. (doi:10.1016/j.yjmcc.2013.05.002) (PMID:23672825)

Pavlovic, D., Hall, A. R., Kennington, E. J., Aughton, K., Boguslavskyi, A., Fuller, W. , Despa, S., Bers, D. M. and Shattock, M. J. (2013) Nitric oxide regulates cardiac intracellular Na+ and Ca2+ by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanism. Journal of Molecular and Cellular Cardiology, 61, pp. 164-171. (doi:10.1016/j.yjmcc.2013.04.013) (PMID:23612119) (PMCID:PMC3981027)

Wypijewski, K. J., Howie, J., Reilly, L., Tulloch, L. B., Aughton, K. L., McLatchie, L. M., Shattock, M. J., Calaghan, S. C. and Fuller, W. (2013) A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump. Journal of Biological Chemistry, 288(19), pp. 13808-13820. (doi:10.1074/jbc.M113.460956) (PMID:23532852) (PMCID:PMC3650417)

Fuller, W. , Tulloch, L.B., Shattock, M.J., Calaghan, S.C., Howie, J. and Wypijewski, K.J. (2013) Regulation of the cardiac sodium pump. Cellular and Molecular Life Sciences, 70(8), pp. 1357-1380. (doi:10.1007/s00018-012-1134-y) (PMID:22955490) (PMCID:PMC3607738)

Howie, J., Tulloch, L. B., Shattock, M. J. and Fuller, W. (2013) Regulation of the cardiac Na+ pump by palmitoylation of its catalytic and regulatory subunits. Biochemical Society Transactions, 41(1), pp. 95-100. (doi:10.1042/BST20120269) (PMID:23356265)

2011

El-Armouche, A., Wittköpper, K., Fuller, W. , Howie, J., Shattock, M. J. and Pavlovic, D. (2011) Phospholemman-dependent regulation of the cardiac Na/K-ATPase activity is modulated by inhibitor-1 sensitive type-1 phosphatase. FASEB Journal, 25(12), pp. 4467-4475. (doi:10.1096/fj.11-184903) (PMID:21849407)

Tulloch, L. B., Howie, J., Wypijewski, K. J., Wilson, C. R., Bernard, W. G., Shattock, M. J. and Fuller, W. (2011) The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation. Journal of Biological Chemistry, 286(41), pp. 36020-36031. (doi:10.1074/jbc.M111.282145) (PMID:21868384) (PMCID:PMC3195638)

2010

Madhani, M., Hall, A. R., Cuello, F., Charles, R. L., Burgoyne, J. R., Fuller, W. , Hobbs, A. J., Shattock, M. J. and Eaton, P. (2010) Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury. American Journal of Physiology: Heart and Circulatory Physiology, 299(3), H827-H836. (doi:10.1152/ajpheart.00129.2010) (PMID:20543084) (PMCID:PMC2944484)

2009

Fuller, W. , Howie, J., McLatchie, L. M., Weber, R. J., Hastie, C. J., Burness, K., Pavlovic, D. and Shattock, M. J. (2009) FXYD1 phosphorylation in vitro and in adult rat cardiac myocytes: threonine 69 is a novel substrate for protein kinase C. American Journal of Physiology: Cell Physiology, 296(6), C1346-C1355. (doi:10.1152/ajpcell.00523.2008) (PMID:19339511) (PMCID:PMC2692419)

2008

Armitage, J. A., Gupta, S., Wood, C., Jensen, R. I., Samuelsson, A.-M., Fuller, W. , Shattock, M. J., Poston, L. and Taylor, P. D. (2008) Maternal dietary supplementation with saturated, but not monounsaturated or polyunsaturated fatty acids, leads to tissue-specific inhibition of offspring Na+,K+-ATPase. Journal of Physiology, 586(20), pp. 5013-5022. (doi:10.1113/jphysiol.2008.157818) (PMID:18718984)

Pavlović, D., Fuller, W. and Shattock, M. J. (2008) The intracellular region of FXYD1 is sufficient to regulate cardiac Na/K ATPase. FASEB Journal, 21(7), pp. 1539-1546. (doi:10.1096/fj.06-7269com) (PMID:17283221)

Bell, J. R. et al. (2008) Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity. American Journal of Physiology: Heart and Circulatory Physiology, 294(2), H613-H621. (doi:10.1152/ajpheart.01332.2007) (PMID:18065526)

2007

Berry, R. G., Despa, S., Fuller, W. , Bers, D. M. and Shattock, M. J. (2007) Differential distribution and regulation of mouse cardiac Na+/K+-ATPase α1 and α2 subunits in T-tubule and surface sarcolemmal membranes. Cardiovascular Research, 73(1), pp. 92-100. (doi:10.1016/j.cardiores.2006.11.006) (PMID:17157829)

2006

Fuller, W. and Shattock, M.J. (2006) Phospholemman and the cardiac sodium pump: protein kinase C, take a bow. Circulation Research, 99(12), pp. 1290-1292. (doi:10.1161/01.RES.0000253090.54488.81) (PMID:17158344)

Brennan, J. P., Bardswell, S. C., Burgoyne, J. R., Fuller, W. , Schröder, E., Wait, R., Begum, S., Kentish, J. C. and Eaton, P. (2006) Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation. Journal of Biological Chemistry, 281(31), pp. 21827-21836. (doi:10.1074/jbc.M603952200) (PMID:16754666)

2005

Brennan, J. P., Miller, J. I.A., Fuller, W. , Wait, R., Begum, S., Dunn, M. J. and Eaton, P. (2005) The utility of N,N-biotinyl glutathione disulfide in the study of protein S-glutathiolation. Molecular and Cellular Proteomics, 5(2), pp. 215-225. (doi:10.1074/mcp.M500212-MCP200) (PMID:16223748)

Silverman, B. d.Z., Fuller, W. , Eaton, P., Deng, J., Moorman, J. R., Cheung, J. Y., James, A. F. and Shattock, M. J. (2005) Serine 68 phosphorylation of phospholemman: acute isoform-specific activation of cardiac Na/K ATPase. Cardiovascular Research, 65(1), pp. 93-103. (doi:10.1016/j.cardiores.2004.09.005) (PMID:15621037)

2004

Fuller, W. , Eeaton, P., Bell, J. R. and Shattock, M. J. (2004) Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase. FASEB Journal, 18(1), pp. 197-199. (doi:10.1096/fj.03-0213fje) (PMID:14597563)

2003

Cuthbert, A. W. and Fuller, W. (2003) Investigation of folding and degradation of in vitro synthesized mutant proteins in microsomes. Methods in Molecular Biology, 232, pp. 265-284. (doi:10.1385/1-59259-394-1:265) (PMID:12840556)

2002

Eaton, P., Fuller, W. and Shattock, M. J. (2002) S-thiolation of HSP27 regulates its multimeric aggregate size independently of phosphorylation. Journal of Biological Chemistry, 277(24), pp. 21189-21196. (doi:10.1074/jbc.M200591200) (PMID:11925435)

Fuller, W. , Parmar, V., Eaton, P., Bell, J. R. and Shattock, M. J. (2002) Cardiac ischemia causes inhibition of the Na/K ATPase by a labile cytosolic compound whose production is linked to oxidant stress. Cardiovascular Research, 57(4), pp. 1044-1051. (doi:10.1016/S0008-6363(02)00810-6) (PMID:12650882)

Medina, R. A., Southworth, R., Fuller, W. and Garlick, P. B. (2002) Lactate-induced translocation of GLUT1 and GLUT4 is not mediated by the phosphatidylinositol-3-kinase pathway in the rat heart. Basic Research in Cardiology, 97(2), pp. 168-176. (doi:10.1007/s003950200008) (PMID:12002265)

2001

Fuller, W. , Eaton, P., Medina, R. A., Bell, J. and Shattock, M. J. (2001) Differential centrifugation separates cardiac sarcolemmal and endosomal membranes from Langendorff-perfused rat hearts. Analytical Biochemistry, 293(2), pp. 216-223. (doi:10.1006/abio.2001.5127) (PMID:11399035)

Eaton, P., Fuller, W. , Bell, J. R. and Shattock, M. J. (2001) Alpha B crystallin translocation and phosphorylation: signal transduction pathways and preconditioning in the isolated rat heart. Journal of Molecular and Cellular Cardiology, 33(9), pp. 1659-1671. (doi:10.1006/jmcc.2001.1418) (PMID:11549345)

2000

Fuller, W. and Cuthbert, A. W. (2000) Post-translational disruption of the delta F508 cystic fibrosis transmembrane conductance regulator (CFTR)-molecular chaperone complex with geldanamycin stabilizes delta F508 CFTR in the rabbit reticulocyte lysate. Journal of Biological Chemistry, 275(48), pp. 37462-37468. (doi:10.1074/jbc.M006278200) (PMID:10982807)

This list was generated on Fri Dec 14 15:55:28 2018 GMT.
Jump to: Articles
Number of items: 36.

Articles

Howie, J., Wypijewski, K. J., Plain, F., Tulloch, L. B., Fraser, N. J. and Fuller, W. (2018) Greasing the wheels or a spanner in the works? Regulation of the cardiac sodium pump by palmitoylation. Critical Reviews in Biochemistry and Molecular Biology, 53(2), pp. 175-191. (doi:10.1080/10409238.2018.1432560) (PMID:29424237)

Logie, L. et al. (2017) Rab-GTPase binding effector protein 2 (RABEP2) is a primed substrate for Glycogen Synthase kinase-3 (GSK3). Scientific Reports, 7(1), 17682. (doi:10.1038/s41598-017-17087-6) (PMID:29247183) (PMCID:PMC5732219)

Petrushanko, I. Y. et al. (2017) Cysteine residues 244 and 458–459 within the catalytic subunit of Na,K-ATPase control the enzyme's hydrolytic and signaling function under hypoxic conditions. Redox Biology, 13, pp. 310-319. (doi:10.1016/j.redox.2017.05.021) (PMID:28601781) (PMCID:PMC5470536)

Plain, F., Congreve, S. D., Yee, R. S. Z., Kennedy, J., Howie, J., Kuo, C.-W., Fraser, N. J. and Fuller, W. (2017) An amphipathic α-helix directs palmitoylation of the large intracellular loop of the sodium/calcium exchanger. Journal of Biological Chemistry, 292(25), pp. 10745-10752. (doi:10.1074/jbc.M116.773945) (PMID:28432123) (PMCID:PMC5481580)

Hurst, C. H., Turnbull, D., Plain, F., Fuller, W. and Hemsley, P. A. (2017) Maleimide scavenging enhances determination of protein S-palmitoylation state in acyl-exchange methods. BioTechniques, 62(2), pp. 69-75. (doi:10.2144/000114516) (PMID:28193150) (PMCID:PMC5400063)

Plain, F., Turnbull, D., Fraser, N. J. and Fuller, W. (2017) Understanding the rules governing NCX1 palmitoylation. Channels, 11(5), pp. 377-379. (doi:10.1080/19336950.2017.1342501) (PMID:28617626)

Reilly, L., Howie, J., Wypijewski, K., Ashford, M. L. J., Hilgemann, D. W. and Fuller, W. (2015) Palmitoylation of the Na/Ca exchanger cytoplasmic loop controls its inactivation and internalization during stress signaling. FASEB Journal, 29(11), pp. 4532-4543. (doi:10.1096/fj.15-276493) (PMID:26174834) (PMCID:PMC4608915)

Eykyn, T. R., Aksentijević, D., Aughton, K. L., Southworth, R., Fuller, W. and Shattock, M. J. (2015) Multiple quantum filtered 23Na NMR in the Langendorff perfused mouse heart: Ratio of triple/double quantum filtered signals correlates with [Na]i. Journal of Molecular and Cellular Cardiology, 86, pp. 95-101. (doi:10.1016/j.yjmcc.2015.07.009) (PMID:26196304) (PMCID:pmc4564289)

Wypijewski, K. J., Tinti, M., Chen, W., Lamont, D., Ashford, M. L. J., Calaghan, S. C. and Fuller, W. (2015) Identification of caveolar resident proteins in ventricular myocytes using a quantitative proteomic approach: dynamic changes in caveolar composition following adrenoceptor activation. Molecular and Cellular Proteomics, 14(3), pp. 596-608. (doi:10.1074/mcp.M114.038570) (PMID:25561500) (PMCID:PMC4349980)

Howie, J. et al. (2014) Substrate recognition by the cell surface palmitoyl transferase DHHC5. Proceedings of the National Academy of Sciences of the United States of America, 111(49), pp. 17534-17539. (doi:10.1073/pnas.1413627111) (PMID:25422474) (PMCID:PMC4267385)

Boguslavskyi, A., Pavlovic, D., Aughton, K., Clark, J. E., Howie, J., Fuller, W. and Shattock, M. J. (2014) Cardiac hypertrophy in mice expressing unphosphorylatable phospholemman. Cardiovascular Research, 104(1), pp. 72-82. (doi:10.1093/cvr/cvu182) (PMID:25103111) (PMCID:PMC4174889)

Pavlovic, D., Fuller, W. and Shattock, M. J. (2013) Novel regulation of cardiac Na pump via phospholemman. Journal of Molecular and Cellular Cardiology, 61, pp. 83-93. (doi:10.1016/j.yjmcc.2013.05.002) (PMID:23672825)

Pavlovic, D., Hall, A. R., Kennington, E. J., Aughton, K., Boguslavskyi, A., Fuller, W. , Despa, S., Bers, D. M. and Shattock, M. J. (2013) Nitric oxide regulates cardiac intracellular Na+ and Ca2+ by modulating Na/K ATPase via PKCε and phospholemman-dependent mechanism. Journal of Molecular and Cellular Cardiology, 61, pp. 164-171. (doi:10.1016/j.yjmcc.2013.04.013) (PMID:23612119) (PMCID:PMC3981027)

Wypijewski, K. J., Howie, J., Reilly, L., Tulloch, L. B., Aughton, K. L., McLatchie, L. M., Shattock, M. J., Calaghan, S. C. and Fuller, W. (2013) A separate pool of cardiac phospholemman that does not regulate or associate with the sodium pump. Journal of Biological Chemistry, 288(19), pp. 13808-13820. (doi:10.1074/jbc.M113.460956) (PMID:23532852) (PMCID:PMC3650417)

Fuller, W. , Tulloch, L.B., Shattock, M.J., Calaghan, S.C., Howie, J. and Wypijewski, K.J. (2013) Regulation of the cardiac sodium pump. Cellular and Molecular Life Sciences, 70(8), pp. 1357-1380. (doi:10.1007/s00018-012-1134-y) (PMID:22955490) (PMCID:PMC3607738)

Howie, J., Tulloch, L. B., Shattock, M. J. and Fuller, W. (2013) Regulation of the cardiac Na+ pump by palmitoylation of its catalytic and regulatory subunits. Biochemical Society Transactions, 41(1), pp. 95-100. (doi:10.1042/BST20120269) (PMID:23356265)

El-Armouche, A., Wittköpper, K., Fuller, W. , Howie, J., Shattock, M. J. and Pavlovic, D. (2011) Phospholemman-dependent regulation of the cardiac Na/K-ATPase activity is modulated by inhibitor-1 sensitive type-1 phosphatase. FASEB Journal, 25(12), pp. 4467-4475. (doi:10.1096/fj.11-184903) (PMID:21849407)

Tulloch, L. B., Howie, J., Wypijewski, K. J., Wilson, C. R., Bernard, W. G., Shattock, M. J. and Fuller, W. (2011) The inhibitory effect of phospholemman on the sodium pump requires its palmitoylation. Journal of Biological Chemistry, 286(41), pp. 36020-36031. (doi:10.1074/jbc.M111.282145) (PMID:21868384) (PMCID:PMC3195638)

Madhani, M., Hall, A. R., Cuello, F., Charles, R. L., Burgoyne, J. R., Fuller, W. , Hobbs, A. J., Shattock, M. J. and Eaton, P. (2010) Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury. American Journal of Physiology: Heart and Circulatory Physiology, 299(3), H827-H836. (doi:10.1152/ajpheart.00129.2010) (PMID:20543084) (PMCID:PMC2944484)

Fuller, W. , Howie, J., McLatchie, L. M., Weber, R. J., Hastie, C. J., Burness, K., Pavlovic, D. and Shattock, M. J. (2009) FXYD1 phosphorylation in vitro and in adult rat cardiac myocytes: threonine 69 is a novel substrate for protein kinase C. American Journal of Physiology: Cell Physiology, 296(6), C1346-C1355. (doi:10.1152/ajpcell.00523.2008) (PMID:19339511) (PMCID:PMC2692419)

Armitage, J. A., Gupta, S., Wood, C., Jensen, R. I., Samuelsson, A.-M., Fuller, W. , Shattock, M. J., Poston, L. and Taylor, P. D. (2008) Maternal dietary supplementation with saturated, but not monounsaturated or polyunsaturated fatty acids, leads to tissue-specific inhibition of offspring Na+,K+-ATPase. Journal of Physiology, 586(20), pp. 5013-5022. (doi:10.1113/jphysiol.2008.157818) (PMID:18718984)

Pavlović, D., Fuller, W. and Shattock, M. J. (2008) The intracellular region of FXYD1 is sufficient to regulate cardiac Na/K ATPase. FASEB Journal, 21(7), pp. 1539-1546. (doi:10.1096/fj.06-7269com) (PMID:17283221)

Bell, J. R. et al. (2008) Characterization of the phospholemman knockout mouse heart: depressed left ventricular function with increased Na-K-ATPase activity. American Journal of Physiology: Heart and Circulatory Physiology, 294(2), H613-H621. (doi:10.1152/ajpheart.01332.2007) (PMID:18065526)

Berry, R. G., Despa, S., Fuller, W. , Bers, D. M. and Shattock, M. J. (2007) Differential distribution and regulation of mouse cardiac Na+/K+-ATPase α1 and α2 subunits in T-tubule and surface sarcolemmal membranes. Cardiovascular Research, 73(1), pp. 92-100. (doi:10.1016/j.cardiores.2006.11.006) (PMID:17157829)

Fuller, W. and Shattock, M.J. (2006) Phospholemman and the cardiac sodium pump: protein kinase C, take a bow. Circulation Research, 99(12), pp. 1290-1292. (doi:10.1161/01.RES.0000253090.54488.81) (PMID:17158344)

Brennan, J. P., Bardswell, S. C., Burgoyne, J. R., Fuller, W. , Schröder, E., Wait, R., Begum, S., Kentish, J. C. and Eaton, P. (2006) Oxidant-induced activation of type I protein kinase A is mediated by RI subunit interprotein disulfide bond formation. Journal of Biological Chemistry, 281(31), pp. 21827-21836. (doi:10.1074/jbc.M603952200) (PMID:16754666)

Brennan, J. P., Miller, J. I.A., Fuller, W. , Wait, R., Begum, S., Dunn, M. J. and Eaton, P. (2005) The utility of N,N-biotinyl glutathione disulfide in the study of protein S-glutathiolation. Molecular and Cellular Proteomics, 5(2), pp. 215-225. (doi:10.1074/mcp.M500212-MCP200) (PMID:16223748)

Silverman, B. d.Z., Fuller, W. , Eaton, P., Deng, J., Moorman, J. R., Cheung, J. Y., James, A. F. and Shattock, M. J. (2005) Serine 68 phosphorylation of phospholemman: acute isoform-specific activation of cardiac Na/K ATPase. Cardiovascular Research, 65(1), pp. 93-103. (doi:10.1016/j.cardiores.2004.09.005) (PMID:15621037)

Fuller, W. , Eeaton, P., Bell, J. R. and Shattock, M. J. (2004) Ischemia-induced phosphorylation of phospholemman directly activates rat cardiac Na/K-ATPase. FASEB Journal, 18(1), pp. 197-199. (doi:10.1096/fj.03-0213fje) (PMID:14597563)

Cuthbert, A. W. and Fuller, W. (2003) Investigation of folding and degradation of in vitro synthesized mutant proteins in microsomes. Methods in Molecular Biology, 232, pp. 265-284. (doi:10.1385/1-59259-394-1:265) (PMID:12840556)

Eaton, P., Fuller, W. and Shattock, M. J. (2002) S-thiolation of HSP27 regulates its multimeric aggregate size independently of phosphorylation. Journal of Biological Chemistry, 277(24), pp. 21189-21196. (doi:10.1074/jbc.M200591200) (PMID:11925435)

Fuller, W. , Parmar, V., Eaton, P., Bell, J. R. and Shattock, M. J. (2002) Cardiac ischemia causes inhibition of the Na/K ATPase by a labile cytosolic compound whose production is linked to oxidant stress. Cardiovascular Research, 57(4), pp. 1044-1051. (doi:10.1016/S0008-6363(02)00810-6) (PMID:12650882)

Medina, R. A., Southworth, R., Fuller, W. and Garlick, P. B. (2002) Lactate-induced translocation of GLUT1 and GLUT4 is not mediated by the phosphatidylinositol-3-kinase pathway in the rat heart. Basic Research in Cardiology, 97(2), pp. 168-176. (doi:10.1007/s003950200008) (PMID:12002265)

Fuller, W. , Eaton, P., Medina, R. A., Bell, J. and Shattock, M. J. (2001) Differential centrifugation separates cardiac sarcolemmal and endosomal membranes from Langendorff-perfused rat hearts. Analytical Biochemistry, 293(2), pp. 216-223. (doi:10.1006/abio.2001.5127) (PMID:11399035)

Eaton, P., Fuller, W. , Bell, J. R. and Shattock, M. J. (2001) Alpha B crystallin translocation and phosphorylation: signal transduction pathways and preconditioning in the isolated rat heart. Journal of Molecular and Cellular Cardiology, 33(9), pp. 1659-1671. (doi:10.1006/jmcc.2001.1418) (PMID:11549345)

Fuller, W. and Cuthbert, A. W. (2000) Post-translational disruption of the delta F508 cystic fibrosis transmembrane conductance regulator (CFTR)-molecular chaperone complex with geldanamycin stabilizes delta F508 CFTR in the rabbit reticulocyte lysate. Journal of Biological Chemistry, 275(48), pp. 37462-37468. (doi:10.1074/jbc.M006278200) (PMID:10982807)

This list was generated on Fri Dec 14 15:55:28 2018 GMT.