Professor George Baillie
- Professor of Molecular Pharmacology (Cardiovascular & Metabolic Health)
telephone:
01413301662
email:
George.Baillie@glasgow.ac.uk
R534, Wolfson Link Building, Glasgow G12 8QQ
https://orcid.org/0000-0003-2469-6316Biography
BSc (Hons) Botany at the University of Glasgow 1988 PhD in Protein Biochemistry, Pfizer (University of Kent) 1993 Post Doctoral fellow, FBLS Glasgow, 1995-2006 Lecturer , FBLS , University of Glasgow, 2007-2010 Reader in Biochemistry, CVMLS, University of Glasgow, 2010-2013 Professor of Molecular Pharmacology, CVMLS, SCMH, 2013-present.
Research interests
Research Theme: Cardiac Diseases
- The compartmentalisation of PDE4 isoforms and how this underpins receptor specific responses to Beta-adrenergic signalling.
- The post-translational modification of cardiac signalling proteins during disease.
- The turnover of cardiac cAMP signalling proteins by the Ubiquitin proteosome.
- Inhibition of protein-protein interactions as a therapeutic strategy in disease.
Research groups
Publications
2024
Cooke, S. F. et al. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14, 8998. (doi: 10.1038/s41598-024-59451-3) (PMID:38637546)
Sin, Y. Y. et al. (2024) Beta-amyloid associates directly with PDE4D5 to activate the enzyme and reduce cAMP availability. FEBS Letters, (Accepted for Publication)
2023
Gulliver, C., Busiau, T., Byrne, A., Findlay, J. E., Hoffmann, R. and Baillie, G. (2023) cAMP-phosphodiesterase 4D7 (PDE4D7) forms a cAMP signalosome complex with DHX9 and is implicated in prostate cancer progression. Molecular Oncology, (doi: 10.1002/1878-0261.13572) (PMID:38126155) (Early Online Publication)
Gulliver, C., Baillie, G. S. and Hoffmann, R. (2023) Reduced PDE4D7 in prostate cancer correlates with genomic downregulation within the upstream PDE4D coding region. Future Science OA, 9(9), (doi: 10.2144/fsoa-2023-0064) (PMID:37752916) (PMCID:PMC10518809)
Parsons, E. C. , Baillie, G. S. and Hoffmann, R. (2023) Revisiting the roles of cAMP signalling in the progression of prostate cancer. Biochemical Journal, 480(20), pp. 1599-1614. (doi: 10.1042/BCJ20230297)
Gulliver, C., Huss, S., Semjonow, A., Baillie, G. S. and Hoffmann, R. (2023) Loss of PDE4D7 expression promotes androgen independence, neuroendocrine differentiation, and alterations in DNA repair: implications for therapeutic strategies. British Journal of Cancer, (doi: 10.1038/s41416-023-02417-5) (PMID:37740039) (Early Online Publication)
Wright, T. A., Gemmell, A. O., Tejeda, G. S. , Blair, C. M. and Baillie, G. S. (2023) Cancer: phosphodiesterase type 4C (PDE4C), the forgotten subfamily as a therapeutic target. International Journal of Biochemistry and Cell Biology, 162, 106453. (doi: 10.1016/j.biocel.2023.106453) (PMID:37499270)
Zorn, A. and Baillie, G. (2023) Phosphodiesterase 7 as a therapeutic target – Where are we now? Cellular Signalling, 108, 110689. (doi: 10.1016/j.cellsig.2023.110689) (PMID:37120115)
Kyurkchieva, E. and Baillie, G. S. (2023) Short PDE4 isoforms as drug targets in disease. Frontiers in Bioscience: Landmark, 28(7), 133. (doi: 10.31083/j.fbl2807133) (PMID:37525918)
Paes, D. et al. (2023) Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology. Cellular and Molecular Life Sciences, 80(7), 178. (doi: 10.1007/s00018-023-04804-w) (PMID:37306762) (PMCID:PMC10261250)
Brown, A. D., Vergunst, K. L., Branch, M., Blair, C. M., Dupré, D. J., Baillie, G. S. and Langelaan, D. N. (2023) Structural basis of CBP/p300 recruitment by the microphthalmia-associated transcription factor. Biochimica et Biophysica Acta: Molecular Cell Research, (doi: 10.1016/j.bbamcr.2023.119520) (PMID:37353163) (In Press)
Gulliver, C., Huss, S., Semjonow, A., Baillie, G. S. and Hoffmann, R. (2023) The CAPRA&PDE4D5/7/9 prognostic model is significantly associated to adverse post-surgical pathology outcomes. Cancers, 15(1), 262. (doi: 10.3390/cancers15010262) (PMID:36612262) (PMCID:PMC9818961)
2022
Main, A. et al. (2022) Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies. Frontiers in Physiology, 13, 1023237. (doi: 10.3389/fphys.2022.1023237) (PMID:36277202) (PMCID:PMC9581287)
Fertig, B. et al. (2022) SUMOylation does not affect cardiac troponin I stability but alters indirectly the development of force in response to Ca2+. FEBS Journal, 289(20), pp. 6267-6285. (doi: 10.1111/febs.16537) (PMID:35633070) (PMCID:PMC9588612)
Stathopoulou, K. et al. (2022) CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes. FEBS Journal, 289(15), pp. 4622-4645. (doi: 10.1111/febs.16402) (PMID:35176204)
Gulliver, C., Hoffmann, R. and Baillie, G. S. (2022) Ataxia-telangiectasia mutated and ataxia telangiectasia and Rad3-related kinases as therapeutic targets and stratification indicators for prostate cancer. International Journal of Biochemistry and Cell Biology, 147, 106230. (doi: 10.1016/j.biocel.2022.106230) (PMID:35609768)
Tibbo, A. J. et al. (2022) Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins. Journal of Molecular and Cellular Cardiology, 165, pp. 86-102. (doi: 10.1016/j.yjmcc.2022.01.001) (PMID:34999055) (PMCID:PMC8986152)
Baillie, G. et al. (2022) Evaluating the Utility of Bi-functional Degrader Molecules for Selective Inhibition of PDE4 In Acrodysostosis Type2. 60th Annual ESPE (ESPE 2022), Rome, Italy, 15-17 Sept 2022.
2021
Mahindra, A. et al. (2021) Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction. PLoS ONE, 16(11), e0260283. (doi: 10.1371/journal.pone.0260283) (PMID:34793553) (PMCID:PMC8601423)
Buist, H. K. et al. (2021) Identification and characterization of an affimer affinity reagent for the detection of the cAMP sensor, EPAC1. Cells, 10(9), 2307. (doi: 10.3390/cells10092307)
Morgan, D. C. et al. (2021) Stapled ACE2 peptidomimetics designed to target the SARS-CoV-2 spike protein do not prevent virus internalisation. Peptide Science, 113(4), e24217. (doi: 10.1002/pep2.24217) (PMID:33615115) (PMCID:PMC7883042)
Scott, M. et al. (2021) The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signalling axis. Oncogene, 40(12), pp. 2243-2257. (doi: 10.1038/s41388-021-01704-w) (PMID:33649538)
Baillie, G. S. , Gulliver, C. and Hoffmann, R. (2021) The enigmatic helicase DHX9 and its association with the hallmarks of cancer. Future Science OA, 7(2), FSO650. (doi: 10.2144/fsoa-2020-0140) (PMID:33437516) (PMCID:PMC7787180)
2020
Main, A., Fuller, W. and Baillie, G. S. (2020) Post-translational regulation of cardiac myosin binding protein-C: a graphical review. Cellular Signalling, 76, 109788. (doi: 10.1016/j.cellsig.2020.109788) (PMID:32976931)
Zou, Z.-G. et al. (2020) Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function. Clinical Science, 134(15), pp. 2019-2035. (doi: 10.1042/CS20200827) (PMID:32706027) (PMCID:PMC8299307)
Williams, J. J.L., Baillie, G. S. and Palmer, T. M. (2020) Investigation of Novel Cavin-1/Suppressor of Cytokine Signaling 3 (SOCS3) Interactions by Coimmunoprecipitation, Peptide Pull-Down, and Peptide Array Overlay Approaches. In: Blouin, C. M. (ed.) Caveolae. Series: Methods in Molecular Biology (2169). Springer: New york, NY, pp. 105-118. ISBN 9781071607312 (doi: 10.1007/978-1-0716-0732-9_10)
Gök, C. , Plain, F., Robertson, A., Howie, J., Baillie, G. S. , Fraser, N. J. and Fuller, W. (2020) Dynamic palmitoylation of the sodium-calcium exchanger modulates its structure, affinity for lipid ordered domains, and inhibition by XIP. Cell Reports, 31(10), 107697. (doi: 10.1016/j.celrep.2020.107697) (PMID:32521252) (PMCID:PMC7296346)
Ling, J., Blair, C. M. and Baillie, G. S. (2020) Fibrin Breakdown Assay. Bio-Protocol, 10(8), e3585. (doi: 10.21769/BioProtoc.3585)
Blair, C. M., Ling, J. and Baillie, G. S. (2020) Measuring cAMP specific phosphodiesterase activity: a two-step radioassay. Bio-Protocol, 10(7), e3581. (doi: 10.21769/BioProtoc.3581) (PMID:33659551) (PMCID:PMC7842805)
Lochhead, M. R., Brown, A. D., Kirlin, A. C., Chitayat, S., Munro, K., Findlay, J. E., Baillie, G. S. , LeBrun, D. P., Langelaan, D. N. and Smith, S. P. (2020) Structural insights into TAZ2 domain-mediated CBP/p300 recruitment by transactivation domain 1 of the lymphopoietic transcription factor E2A. Journal of Biological Chemistry, 27, pp. 4303-4315. (doi: 10.1074/jbc.RA119.011078) (PMID:32098872)
Tejeda, G. S. , Whiteley, E. L., Deeb, T. Z., Bürli, R. W., Moss, S. J., Sheridan, E., Brandon, N. J. and Baillie, G. S. (2020) Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme. Proceedings of the National Academy of Sciences of the United States of America, 117(1), pp. 677-688. (doi: 10.1073/pnas.1916398117) (PMID:31871190) (PMCID:PMC6955301)
Baillie, G. and Tibbo, A. (2020) Phosphodiesterase 4B: master regulator of brain signaling. Cells, 9(5), 1254. (doi: 10.3390/cells9051254) (PMID:32438615) (PMCID:PMC7291338)
2019
Baillie, G. S. , Tejeda, G. S. and Kelly, M. P. (2019) Therapeutic targeting of 3’,5’-cyclic nucleotide phosphodiesterases: inhibition and beyond. Nature Reviews Drug Discovery, 18, pp. 770-796. (doi: 10.1038/s41573-019-0033-4) (PMID:31388135)
Blair, C. M. and Baillie, G. S. (2019) Reshaping cAMP nanodomains through targeted disruption of compartmentalised phosphodiesterase signalosomes. Biochemical Society Transactions, 47(5), pp. 1405-1414. (doi: 10.1042/BST20190252) (PMID:31506329)
Tibbo, A. J., Tejeda, G. S. and Baillie, G. S. (2019) Understanding PDE4's function in Alzheimer's disease; a target for novel therapeutic approaches. Biochemical Society Transactions, 47(5), pp. 1557-1565. (doi: 10.1042/BST20190763) (PMID:31642904) (PMCID:PMC6824677)
Whiteley, E. L., Tejeda, G. S. , Baillie, G. S. and Brandon, N. J. (2019) PDE10A mutations help to unwrap the neurobiology of hyperkinetic disorders. Cellular Signalling, 60, pp. 31-38. (doi: 10.1016/j.cellsig.2019.04.001) (PMID:30951862)
Omar, F. et al. (2019) Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases. Proceedings of the National Academy of Sciences of the United States of America, 116(27), pp. 13320-13329. (doi: 10.1073/pnas.1822113116) (PMID:31209056) (PMCID:PMC6613170)
Houslay, K.F., Fertig, B.A., Christian, F., Tibbo, A.J., Ling, J., Findlay, J.E., Houslay, M.D. and Baillie, G.S. (2019) Phosphorylation of PDE4A5 by MAPKAPK2 attenuates fibrin degradation via p75 signalling. Journal of Biochemistry, 166(1), pp. 97-106. (doi: 10.1093/jb/mvz016) (PMID:30859186) (PMCID:PMC6607969)
Wongpiyabovorn, J. et al. (2019) Effect of tarcolimus on skin microbiome in atopic dermatitis. Allergy, 74(7), pp. 1400-1406. (doi: 10.1111/all.13743) (PMID:30742708)
Clister, T., Greenwald, E. C., Baillie, G. S. and Zhang, J. (2019) AKAP95 organizes a nuclear microdomain to control local cAMP for regulating nuclear PKA. Cell Chemical Biology, 26(6), pp. 885-891. (doi: 10.1016/j.chembiol.2019.03.003) (PMID:30982750)
Van Strijp, D., De Witz, C., Heitkoetter, B., Huss, S., Boegemann, M., Baillie, G. S. , Houslay, M. D., Bangma, C., Semjonow, A. and Hoffmann, R. (2019) The association of the long prostate cancer expressed PDE4D transcripts to poor patient outcome depends on the tumor’s TMPRSS2-ERG fusion status. Prostate Cancer, 2019, 8107807. (doi: 10.1155/2019/8107807)
Vagena, E., Ryu, J. K., Baeza-Raja, B., Walsh, N. M., Syme, C., Day, J. P., Houslay, M. and Baillie, G. (2019) A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signalling. Translational Psychiatry, 9(1), 141. (doi: 10.1038/s41398-019-0470-1) (PMID:31076569) (PMCID:PMC6510753)
Blair, C. M., Walsh, N., Littman, B. H., Marcoux, F. W. and Baillie, G. S. (2019) Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A – C-Raf. BMC Cancer, 19, 266. (doi: 10.1186/s12885-019-5489-4) (PMID:30909892) (PMCID:PMC6434832)
Tibbo, A. J., Busiau, T. and Baillie, G. S. (2019) Methods to investigate arrestins in complex with phosphodiesterases. In: Scott, M. G.H. and Laporte, S. A. (eds.) Beta-Arrestins. Series: Methods in molecular biology (1957). Springer: New York, pp. 121-137. (doi: 10.1007/978-1-4939-9158-7_8)
2018
Strembitska, A., Mancini, S. J., Gamwell, J. M., Palmer, T. M., Baillie, G. S. and Salt, I. P. (2018) A769662 inhibits insulin-stimulated Akt activation in human macrovascular endothelial cells independent of AMP-activated protein kinase. International Journal of Molecular Sciences, 19(12), 3886. (doi: 10.3390/ijms19123886) (PMID:30563079) (PMCID:PMC6321332)
Maziarz, M., Broselid, S., DiGiacomo, V., Park, J.-C., Luebbers, A., Garcia-Navarrete, L., Blanco-Canosa, J. B., Baillie, G. S. and Garcia-Marcos, M. (2018) A biochemical and genetic discovery pipeline identifies PLCδ4b as a non-receptor activator of heterotrimeric G proteins. Journal of Biological Chemistry, 293(44), pp. 16964-16983. (doi: 10.1074/jbc.RA118.003580) (PMID:30194280) (PMCID:PMC6222092)
Elliott, C. et al. (2018) A role for APP in Wnt signalling links synapse loss with β-amyloid production. Translational Psychiatry, 8, 179. (doi: 10.1038/s41398-018-0231-6) (PMID:30232325) (PMCID:PMC6145937)
Engelhardt, B., Holze, J., Elliott, C. , Baillie, G.S. , Kschischo, M. and Fröhlich, H. (2018) Modelling and mathematical analysis of the M2 receptor-dependent joint signalling and secondary messenger network in CHO cells. Mathematical Medicine and Biology, 35(3), pp. 279-297. (doi: 10.1093/imammb/dqx003) (PMID:28505258)
Daly, J. P., Whiteley, E., Freeley, M., Long, A., Malacrida, B., Kiely, P. and Baillie, G. S. (2018) RAB40C regulates RACK1 stability via the ubiquitin-proteasome system. Future Science OA, 4(7), FSO317. (doi: 10.4155/fsoa-2018-0022) (PMID:30112187) (PMCID:PMC6088270)
van Strijp, D. et al. (2018) The prognostic PDE4D7 score in a diagnostic biopsy prostate cancer patient cohort with longitudinal biological outcomes. Prostate Cancer, 2018, 5821616. (doi: 10.1155/2018/5821616) (PMID:30147955) (PMCID:PMC6083737)
Armfield, K., Baillie, G. and Wilson, J.B. (2018) Development of Therapeutic Approaches to Targeting Epstein-Barr virus Related Malignancies. International Conference on EBV and KSHV 2018, Wisconsin, USA, 28 Jul - 1 Aug 2018.
de Inda, M. A. et al. (2018) Validation of cyclic adenosine monophosphate phosphodiesterase-4D7 for its independent contribution to risk stratification in a prostate cancer patient cohort with longitudinal biological outcomes. European Urology Focus, 4(3), pp. 376-384. (doi: 10.1016/j.euf.2017.05.010) (PMID:28753810)
Sellers, K. J. et al. (2018) Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil. Alzheimer's and Dementia, 14(3), pp. 306-317. (doi: 10.1016/j.jalz.2017.09.008) (PMID:29055813) (PMCID:PMC5869054)
Fertig, B. A. and Baillie, G. S. (2018) PDE4-mediated cAMP signalling. Journal of Cardiovascular Development and Disease, 5(1), 8. (doi: 10.3390/jcdd5010008)
Williams, J. J.L., Al-Otaiq, N., Mullen, W. , Burchmore, R. , Liu, L., Baillie, G. S. , Schaper, F., Pilch, P. F. and Palmer, T. M. (2018) Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability. Nature Communications, 9, 168. (doi: 10.1038/s41467-017-02585-y) (PMID:29330478) (PMCID:PMC5766592)
Rodrigues, A. L., Brescia, M., Kolshinski, A., Moreira, T. H., Cameron, R. T., Baillie, G. , Beirão, P. S.L., Zaccollo, M. and Cruz, J. S. (2018) Increase in Ca2+ current by sustained cAMP levels enhances proliferation rate in GH3 cells. Life Sciences, 192, pp. 144-150. (doi: 10.1016/j.lfs.2017.11.040) (PMID:29183797)
Yalla, K. et al. (2018) FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system. Molecular Psychiatry, 23(5), pp. 1278-1286. (doi: 10.1038/mp.2017.138) (PMID:28727686) (PMCID:PMC5984089)
2017
Basole, C. P., Nguyen, R. K., Lamothe, K., Vang, A., Clark, R., Baillie, G. S. , Epstein, P. M. and Brocke, S. (2017) PDE8 controls CD4(+) T cell motility through the PDE8A-Raf-1 kinase signaling complex. Cellular Signalling, 40, pp. 62-72. (doi: 10.1016/j.cellsig.2017.08.007) (PMID:28851628)
Lemonidis, K., MacLeod, R., Baillie, G. S. and Chamberlain, L. H. (2017) Peptide array based screening reveals a large number of proteins interacting with the ankyrin repeat domain of the zDHHC17 S-acyltransferase. Journal of Biological Chemistry, 292(42), pp. 17190-17202. (doi: 10.1074/jbc.M117.799650)
Kiely, M., Adams, D. R., Hayes, S. L., O'Connor, R., Baillie, G. S. and Kiely, P. A. (2017) RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells. Cellular Signalling, 35, pp. 290-300. (doi: 10.1016/j.cellsig.2016.09.001) (PMID:27600565)
Nishi, K., Luo, H., Ishikura, S., Doi, K., Iwaihara, Y., Wills, L., Baillie, G. S. , Sakata, T., Shirasawa, S. and Tsunoda, T. (2017) Apremilast induces apoptosis of human colorectal cancer cells with mutant KRAS. Anticancer Research, 37(7), pp. 3833-3839. (doi: 10.21873/anticanres.11762) (PMID:28668883)
Ibáñez de Opakua, A. et al. (2017) Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif. Nature Communications, 8, 15163. (doi: 10.1038/ncomms15163) (PMID:28516903) (PMCID:PMC5454376)
Diamantopoulou, Z. et al. (2017) TIAM1 antagonizes TAZ/YAP both in the destruction complex in the cytoplasm and in the nucleus to inhibit invasion of intestinal epithelial cells. Cancer Cell, 31(5), pp. 621-634. (doi: 10.1016/j.ccell.2017.03.007) (PMID:28416184) (PMCID:PMC5425402)
Monterisi, S. et al. (2017) PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling. eLife, 6, e21374. (doi: 10.7554/eLife.21374) (PMID:28463107) (PMCID:PMC5423767)
Schoenherr, C., Byron, A., Sandilands, E., Paliashvili, K., Baillie, G. S. , Valacca, C., Cecconi, F., Serrels, B. and Frame, M. C. (2017) Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks. eLife, 6, e23172. (doi: 10.7554/eLife.23172) (PMID:28362576)
Houslay, K. F., Christian, F. , MacLeod, R., Adams, D. R., Houslay, M. D. and Baillie, G. S. (2017) Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners. Biochemical Journal, 474(4), pp. 597-609. (doi: 10.1042/BCJ20160849) (PMID:27993970) (PMCID:PMC5290487)
Deschamps, T. et al. (2017) Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle. Journal of General Virology, 98(2), pp. 251-265. (doi: 10.1099/jgv.0.000681) (PMID:28284242)
Cameron, R. T., Whiteley, E., Day, J. P., Parachikova, A. I. and Baillie, G. S. (2017) Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1-42 mediated cytotoxicity. FEBS Open Bio, 7(1), pp. 64-73. (doi: 10.1002/2211-5463.12156) (PMID:28097089) (PMCID:PMC5221464)
Javadi, A., Deevi, R. K., Evergren, E., Blondel-Tepaz, E., Baillie, G. S. , Scott, M. G.H. and Campbell, F. C. (2017) PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex. eLife, 6, e24578. (doi: 10.7554/eLife.24578) (PMID:28749339) (PMCID:PMC5576923)
2016
Rutherford, C. et al. (2016) Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling. Science Signaling, 9(453), ra109. (doi: 10.1126/scisignal.aaf8566) (PMID:27919027)
Böttcher, R., Dulla, K., van Strijp, D., Dits, N., Verhoef, E. I., Baillie, G. S. , Van Leenders, G. J.L.H., Houslay, M. D., Jenster, G. and Hoffmann, R. (2016) Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and development of distant metastases. Oncotarget, 7(43), pp. 70669-70684. (doi: 10.18632/oncotarget.12204) (PMID:27683107) (PMCID:PMC5342582)
Yun, S., Budatha, M., Dahlman, J. E., Coon, B. G., Cameron, R. T., Langer, R., Anderson, D. G., Baillie, G. and Schwartz, M. A. (2016) Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling. Nature Cell Biology, 18(10), pp. 1043-1053. (doi: 10.1038/ncb3405) (PMID:27595237) (PMCID:PMC5301150)
Hood, K. Y., Yusuf, H., Findlay, J. E., Santos, R. A., Castro, C. H., Baillie, G. S. , MacLean, M. R., Montezano, A. and Touyz, R. M. (2016) Ang(1-7) influences ET-1 signaling through Mas: ETBR interactions: implications in pulmonary hypertension. Journal of Hypertension, 34(Supl 1), e216. (doi: 10.1097/01.hjh.0000500475.07008.db) (PMID:27754060)
Hood, K. Y., Yusuf, H., Findlay, J. E., Santos, R. A., Castro, C. H., Baillie, G. S. , Montezano, A. C., MacLean, M. R. and Touyz, R. M. (2016) ANG-(1-7) and ET-1, a new partnership. Journal of Hypertension, 34, e382. (doi: 10.1097/01.hjh.0000500977.99529.fe) (PMID:27754197)
Havekes, R. et al. (2016) Compartmentalized PDE4A5 signaling impairs hippocampal synaptic plasticity and long-term memory. Journal of Neuroscience, 36(34), pp. 8936-8946. (doi: 10.1523/JNEUROSCI.0248-16.2016) (PMID:27559174) (PMCID:PMC4995304)
Havekes, R. et al. (2016) Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1. eLife, 5, e13424. (doi: 10.7554/eLife.13424) (PMID:27549340) (PMCID:PMC4996653)
Roscoe, R. B., Elliott, C. , Zarros, A. and Baillie, G. S. (2016) Non-genetic therapeutic approaches to Canavan disease. Journal of the Neurological Sciences, 366, pp. 116-124. (doi: 10.1016/j.jns.2016.05.012) (PMID:27288788)
Bachmann, V. A. et al. (2016) GPR61 anchoring of PKA consolidates GPCR and cAMP signaling. Proceedings of the National Academy of Sciences of the United States of America, 113(28), pp. 7786-7791. (doi: 10.1073/pnas.1608061113) (PMID:27357676)
Baillie, G. S. (2016) Editorial. Cellular Signalling, 28(7), pp. 699-700. (doi: 10.1016/j.cellsig.2016.02.001) (PMID:26850139)
Wills, L., Ehsan, M., Whiteley, E. L. and Baillie, G. S. (2016) Location, location, location: PDE4D5 function is directed by its unique N-terminal region. Cellular Signalling, 28(7), pp. 701-705. (doi: 10.1016/j.cellsig.2016.01.008) (PMID:26808969)
Dachtler, J., Elliott, C. , Rodgers, R. J., Baillie, G. S. and Clapcote, S. J. (2016) Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice. Scientific Reports, 6, 18748. (doi: 10.1038/srep18748) (PMID:26728762) (PMCID:PMC4700527)
Baillie, G. S. , Christian, F. and Zarros, A. (2016) Editorial: frontiers in the pharmacological manipulation of intracellular cAMP levels. Frontiers in Pharmacology, 7, 4. (doi: 10.3389/fphar.2016.00004) (PMID:26858646) (PMCID:PMC4731503)
Baillie, G. S. , Christian, F. and Zarros, A. (Eds.) (2016) Frontiers in the Pharmacological Manipulation of Intracellular cAMP Levels. Series: Frontiers in pharmacology. Frontiers Media: Lausanne. ISBN 9782889198153
Baeza-Raja, B. et al. (2016) p75 neurotrophin receptor regulates energy balance in obesity. Cell Reports, 14(2), pp. 255-268. (doi: 10.1016/j.celrep.2015.12.028) (PMID:26748707) (PMCID:PMC4831919)
Tankou, S. et al. (2016) SUMOylation of DISC1: a potential role in neural progenitor proliferation in the developing cortex. Molecular Neuropsychiatry, 2(1), pp. 20-27. (doi: 10.1159/000444257) (PMID:27525255) (PMCID:PMC4979612)
2015
Baillie, G. S. (2015) George Baillie on peptide array, a technique that transformed research on phosphodiesterases. Future Science OA, 1(3), FSO27. (doi: 10.4155/fso.15.25) (PMID:28031900) (PMCID:PMC5137849)
MacLeod, R., Hillert, E.-K., Cameron, R. T. and Baillie, G. S. (2015) The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease. Future Science OA, 1(3), FSO11. (doi: 10.4155/fso.15.9) (PMID:28031886) (PMCID:PMC5137966)
Sin, Y. Y. and Baillie, G. (2015) Heat Shock Protein 20 (HSP20) is a novel substrate for Protein Kinase D1 (PKD1). Cell Biochemistry and Function, 33(7), pp. 421-426. (doi: 10.1002/cbf.3147) (PMID:26443497) (PMCID:PMC4973849)
Zoccarato, A. et al. (2015) Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2. Circulation Research, 117, pp. 707-719. (doi: 10.1161/CIRCRESAHA.114.305892) (PMID:26243800)
Mckinney, C.A., Kennedy, S. , Baillie, G.S. , Milligan, G. and Nicklin, S.A. (2015) Angiotensin-(1-7) and angiotensin-(1-9) inhibit vascular smooth muscle cell growth and migration in vitro and vascular remodelling in vivo. Atherosclerosis, 241(1), e44. (doi: 10.1016/j.atherosclerosis.2015.04.158)
Parnell, E., Koschinski, A., Zaccolo, M., Cameron, R. T., Baillie, G. S. , Baillie, G. L., Porter, A., McElroy, S. P. and Yarwood, S. J. (2015) Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells. Biochimica et Biophysica Acta: Molecular Cell Research, 1853(7), pp. 1749-1758. (doi: 10.1016/j.bbamcr.2015.04.009) (PMID:25913012)
Zarros, A., Cameron, R.T., Bimpis, A. and Baillie, G.S. (2015) Exposure of mHIPPOE-14 cells to oligomycin as a tool for in vitro approaches to brain ischaemia-related pro- and epiphenomena: time-dependent cellular response profiling. Atherosclerosis, 241(1), e221. (doi: 10.1016/j.atherosclerosis.2015.04.1038)
Wang, L., Burmeister, B. T., Johnson, K. R., Baillie, G. S. , Karginov, A. V., Skidgel, R. A., O'Bryan, J. P. and Carnegie, G. K. (2015) UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy. Cellular Signalling, 27(5), pp. 908-922. (doi: 10.1016/j.cellsig.2015.02.003) (PMID:25683917)
Bolger, G. B., Dunlop, A. J., Meng, D., Day, J. P., Klussmann, E., Baillie, G. S. , Adams, D. R. and Houslay, M. D. (2015) Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains. Cellular Signalling, 27(4), pp. 756-769. (doi: 10.1016/j.cellsig.2014.12.009) (PMID:25546709) (PMCID:PMC4371794)
Sin, Y. Y., Martin, T. P. , Wills, L., Currie, S. and Baillie, G. S. (2015) Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy. Cell Communication and Signaling, 13, 16. (doi: 10.1186/s12964-015-0094-x) (PMID:25889640) (PMCID:PMC4356135)
Zarros, A. , Johnson, S. A., Mackenzie-Gray Scott, C. A. and Baillie, G. S. (2015) Cytodynamics and endpoint selection for a reliable in vitro assessment of nanoneurotoxicity. Nanomedicine: Nanotechnology, Biology and Medicine, 11(2), pp. 407-408. (doi: 10.1016/j.nano.2014.08.014) (PMID:25461294)
Bottcher, R. et al. (2015) Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression. British Journal of Cancer, 113, pp. 1502-1511. (doi: 10.1038/bjc.2015.335) (PMID:26575822) (PMCID:PMC4815894)
Byrne, A. M., Elliott, C. , Hoffmann, R. and Baillie, G. S. (2015) The activity of cAMP-Phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus. FEBS Letters, 589(6), pp. 750-755. (doi: 10.1016/j.febslet.2015.02.004) (PMID:25680530) (PMCID:PMC4346272)
Kalafatakis, K., Gkanti, V., Mackenzie-Gray Scott, C. A., Zarros, A. , Baillie, G. S. and Tsakiris, S. (2015) Acetylcholinesterase activity as a neurotoxicity marker within the context of experimentally-simulated hyperprolinaemia: an in vitro approach. Journal of Natural Science, Biology and Medicine, 6(3), pp. 98-101. (doi: 10.4103/0976-9668.166099)
McGirr, A. et al. (2015) Specific inhibition of phosphodiesterase-4B results in anxiolysis and facilitates memory acquisition. Neuropsychopharmacology, 41(4), pp. 1080-1092. (doi: 10.1038/npp.2015.240)
2014
Schoenherr, C., Serrels, B., Proby, C., Cunningham, D. L., Findlay, J. E., Baillie, G. S. , Heath, J. K. and Frame, M. (2014) Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells. Journal of Cell Science, 127(24), pp. 5303-5316. (doi: 10.1242/jcs.157560)
Campbell, A. S., Johnstone, S. R., Baillie, G. S. and Smith, G. (2014) β-Adrenergic modulation of myocardial conduction velocity: Connexins vs. sodium current. Journal of Molecular and Cellular Cardiology, 77, pp. 147-154. (doi: 10.1016/j.yjmcc.2014.09.030)
Christian, F. , Krause, E., Houslay, M. D. and Baillie, G. (2014) PKA phosphorylation of p62/SQSTM1 regulates PB1 domain interaction partner binding. Biochimica et Biophysica Acta: Molecular Cell Research, 1843(11), pp. 2765-2774. (doi: 10.1016/j.bbamcr.2014.07.021) (PMID:25110345)
Kaname, T. et al. (2014) Heterozygous mutations in cyclic AMP phosphodiesterase-4D (PDE4D) and protein kinase A (PKA) provide new insights into the molecular pathology of acrodysostosis. Cellular Signalling, 26(11), pp. 2446-2459. (doi: 10.1016/j.cellsig.2014.07.025)
Sheppard, C. L. et al. (2014) Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression. Cellular Signalling, 26(9), pp. 1958-1974. (doi: 10.1016/j.cellsig.2014.04.023)
Zarros, A. , Bimpis, A., Papalois, A. and Baillie, G. S. (2014) Perihaematomal cytokine expression is a crucial component of intracerebral haemorrhage pathophysiology. Neurological Sciences, 35(9), pp. 1471-1473. (doi: 10.1007/s10072-014-1785-6) (PMID:24729011)
Zarros, A. , Byrne, A.-M., Boomkamp, S. D., Tsakiris, S. and Baillie, G. S. (2014) Erratum to: Lanthanum-induced neurotoxicity: solving the riddle of its involvement in cognitive impairment? Archives of Toxicology, 88(9), p. 1767. (doi: 10.1007/s00204-014-1307-6)
McCormick, K. and Baillie, G. S. (2014) Compartmentalisation of second messenger signalling pathways. Current Opinion in Genetics and Development, 27, pp. 20-25. (doi: 10.1016/j.gde.2014.02.001)
Cameron, R. T., Quinn, S. D. , Cairns, L. S., MacLeod, R., Samuel, I. D.W., Smith, B. O. , Penedo, J. C. and Baillie, G. S. (2014) The phosphorylation of Hsp20 enhances its association with amyloid-β to increase protection against neuronal cell death. Molecular and Cellular Neuroscience, 61, pp. 46-55. (doi: 10.1016/j.mcn.2014.05.002) (PMID:24859569) (PMCID:PMC4148482)
Lima-Fernandes, E., Misticone, S., Boularan, C., Paradis, J. S., Enslen, H., Roux, P. P., Bouvier, M., Baillie, G. S. , Marullo, S. and Scott, M. G.H. (2014) A biosensor to monitor dynamic regulation and function of tumour suppressor PTEN in living cells. Nature Communications, 5, (doi: 10.1038/ncomms5431) (PMID:25028204)
Bimpis, A., Baillie, G. S. and Zarros, A. (2014) Cholinergic deregulation in traumatic brain injury could be a pathophysiology-related biphasic epiphenomenon. Medical Journal of Malaysia, 69(3), p. 148. (PMID:25326361)
Martin, T. P. , Currie, S. and Baillie, G. S. (2014) The cardioprotective role of small heat-shock protein 20. Biochemical Society Transactions, 42(2), pp. 270-273. (doi: 10.1042/BST20130272)
Henderson, D.J.P., Byrne, A., Dulla, K., Jenster, G., Hoffmann, R., Baillie, G.S. and Houslay, M.D. (2014) The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells. British Journal of Cancer, 110(5), pp. 1278-1287. (doi: 10.1038/bjc.2014.22)
Campbell, A. S., Burton, F. L., Baillie, G. and Smith, G. L. (2014) Action potential conduction velocity is increased by raised intracellular camp in the intact rat heart via a CaMKII mediated pathway. In: 58th Annual Meeting of the Biophysical-Society, San Francisco CA, USA, 15-19 Feb 2014, 119a.
Quinn, S. D.. , Dalgarno, P. A., Cameron, R. T., Hedley, G. J. , Hacker, C., Lucocq, J. M., Baillie, G. S. , Samuel, I. D.W. and Penedo, J. C. (2014) Real-time probing of β-amyloid self-assembly and inhibition using fluorescence self-quenching between neighbouring dyes. Molecular BioSystems, 10(1), p. 34. (doi: 10.1039/c3mb70272c) (PMID:24170094)
Youn, S., Budatha, M., Baillie, G. and Schwartz, M. (2014) ECM-specific endothelial inflammatory signaling: regulation by integrin alpha5 interaction with PDE4D. In: Vascular Matrix Biology and Bioengineering Workshop IV and Biology of Signaling in the Cardiovascular System Workshop III, Hyannis, MA, USA, 20-24 Oct 2013, p. 313. (doi: 10.1007/s10456-013-9412-3)
Cameron, R.T. and Baillie, G.S. (2014) Arrestin regulation of small GTPases. In: Gurevich, V.V. (ed.) Arrestins: Pharmacology and Therapeutic Potential. Series: Handbook of Experimental Pharmacology (219). Springer, pp. 375-385. ISBN 9783642411991 (doi: 10.1007/978-3-642-41199-1_19)
Martin, T. P. , Hortigon-Vinagre, M. P. , Findlay, J. E., Elliott, C. , Currie, S. and Baillie, G. S. (2014) Targeted disruption of the heat shock protein 20–phosphodiesterase 4D (PDE4D) interaction protects against pathological cardiac remodelling in a mouse model of hypertrophy. FEBS Open Bio, 4, pp. 923-927. (doi: 10.1016/j.fob.2014.10.011) (PMID:25426411) (PMCID:PMC4239479)
Weninger, S., Van Craenenbroeck, K., Cameron, R., Vandeput, F., Movsesian, M.A., Baillie, G.S. and Lefebvre, R.A. (2014) Phosphodiesterase 4 interacts with the 5-HT4(b) receptor to regulate cAMP signaling. Cellular Signalling, 26(11), pp. 2573-2582. (doi: 10.1016/j.cellsig.2014.07.027) (PMID:25101859)
Willis, M.J. and Baillie, G.S. (2014) Arrestin-dependent localization of phosphodiesterases. In: Gurevich, V.V. (ed.) Arrestins: Pharmacology and Therapeutic Potential. Series: Handbook of Experimental Pharmacology (219). Springer, pp. 293-307. ISBN 9783642411991 (doi: 10.1007/978-3-642-41199-1_15)
2013
Zarros, A. , Boomkamp, S. D., Tsakiris, S. and Baillie, G. S. (2013) The extent and the nature of the cholinergic contribution to the hepatic encephalopathy-induced cognitive impairment. Free Radical Biology and Medicine, 65, pp. 1516-1517. (doi: 10.1016/j.freeradbiomed.2013.08.165) (PMID:23973861)
Zarros, A. , Byrne, A.-M., Boomkamp, S.D., Tsakiris, S. and Baillie, G.S. (2013) Lanthanum-induced neurotoxicity: solving the riddle of its involvement in cognitive impairment? Archives of Toxicology, 87(11), pp. 2031-2035. (doi: 10.1007/s00204-013-1112-7) (PMID:23934103)
Zarros, A. , Cameron, R.T., Tsakiris, S. and Baillie, G.S. (2013) Evaluating the suitability of postnuclear supernatants as in vitro models for assessing cadmium- and other xenobiotic-induced neurotoxicity on crucial enzymatic parameters. Biological Trace Element Research, 152(3), pp. 297-299. (doi: 10.1007/s12011-013-9626-7) (PMID:23408262)
Zarros, A. , Kalopita, K., Tsakiris, S. and Baillie, G. S. (2013) Can acetylcholinesterase activity be considered as a reliable biomarker for the assessment of cadmium-induced neurotoxicity? Food and Chemical Toxicology, 56, pp. 406-410. (doi: 10.1016/j.fct.2013.02.048) (PMID:23474324)
Bachmann, V.A., Riml, A., Huber, R.G., Baillie, G.S. , Liedl, K.R., Valovka, T. and Stefan, E. (2013) Reciprocal regulation of PKA and rac signaling. Proceedings of the National Academy of Sciences of the United States of America, 110(21), pp. 8531-8536. (doi: 10.1073/pnas.1215902110)
Cameron, R.T., Coleman, R.G., Day, J.P., Yalla, K.C., Houslay, M.D., Adams, D.R., Shoichet, B.K. and Baillie, G.S. (2013) Chemical informatics uncovers a new role for moexipril as a novel inhibitor of cAMP phosphodiesterase-4 (PDE4). Biochemical Pharmacology, 85(9), pp. 1297-1305. (doi: 10.1016/j.bcp.2013.02.026) (PMID:23473803) (PMCID:PMC3625111)
Brown, K.M. et al. (2013) Phosphodiesterase-8A binds to and regulates Raf-1 kinase. Proceedings of the National Academy of Sciences of the United States of America, 110(16), E1533-E1542. (doi: 10.1073/pnas.1303004110)
Berthouze-Duquesnes, M., Lucas, A., Saulière, A., Sin, Y.Y., Laurent, A.C., Galés, C., Baillie, G. and Lezoualc'h, F. (2013) Specific interactions between Epac1, β-arrestin2 and PDE4D5 regulate β-adrenergic receptor subtype differential effects on cardiac hypertrophic signaling. Cellular Signalling, 25(4), pp. 970-980. (doi: 10.1016/j.cellsig.2012.12.007) (PMID:23266473)
Murcia, P.R. et al. (2013) Evolution of equine influenza virus in vaccinated horses. Journal of Virology, 87(8), pp. 4768-4771. (doi: 10.1128/JVI.03379-12)
Lee, L.C.Y., Maurice, D.H. and Baillie, G.S. (2013) Targeting protein–protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease. Future Medicinal Chemistry, 5(4), pp. 451-464. (doi: 10.4155/fmc.12.216)
Iti Scotland Limited (2013) New Substituted Peptide Compounds are Beta Transducin Repeat-Containing Protein Modulators, Useful for Treating e.g. Breast Cancer, Arthritis, Osteoarthritis, Rheumatoid Arthritis, Crohn's Disease and Irritable Bowel Syndrome. .
Ron, D., Adams, D.R., Baillie, G.S. , Long, A., O’Connor, R. and Kiely, P.A. (2013) RACK(1) to the future – a historical perspective. Cell Communication and Signaling, 11(53), (doi: 10.1186/1478-811X-11-53)
2012
Havekes, R. et al. (2012) Gravin orchestrates protein kinase A and 2-adrenergic receptor signaling critical for synaptic plasticity and memory. Journal of Neuroscience, 32(50), pp. 18137-18149. (doi: 10.1523/JNEUROSCI.3612-12.2012)
Hussain, M., Baillie, G. , Gatherer, D. and Wilson, J.B. (2012) Investigating Molecular Interactions Between Epstein-Barr Virus Nuclear Antigen-1 and Partner Proteins. International Congress on Oncogenic Herpesviruses and Associated Diseases, Philadelphia, PA, USA, 01-05 Aug 2012.
Hussain, M., Baillie, G. , Gatherer, D. and Wilson, J.B. (2012) Investigating Molecular Interactions Between Epstein-Barr Virus Nuclear Antigen-1 and Partner Proteins. Tenovus 30th Aniversary Symposium: Molecular Mechanisms of Disease, Glasgow, UK, 6-7 Jun 2012.
Brown, K. M., Lee, L. C.Y., Findlay, J. E., Day, J. P. and Baillie, G. S. (2012) Cyclic AMP-specific phosphodiesterase, PDE8A1, is activated by protein kinase A-mediated phosphorylation. FEBS Letters, 586(11), pp. 1631-1637. (doi: 10.1016/j.febslet.2012.04.033)
The University Court of The University of Glasgow (2012) Increasing HSP20 Activation in Biological Systems Involves Antagonists Capable of Inhibiting PDE4 Binding. .
Edwards, H. V., Christian, F. and Baillie, G. S. (2012) cAMP: Novel concepts in compartmentalised signalling. Seminars in Cell and Developmental Biology, 23(2), pp. 181-190. (doi: 10.1016/j.semcdb.2011.09.005)
Edwards, H. V., Scott, J. D. and Baillie, G. S. (2012) PKA phosphorylation of the small heat-shock protein Hsp20 enhances its cardioprotective effects. Biochemical Society Transactions, 40(1), pp. 210-214. (doi: 10.1042/BST20110673)
Sin, Y. Y. and Baillie, G. S. (2012) Protein kinase D in the hypertrophy pathway. Biochemical Society Transactions, 40(1), pp. 287-289. (doi: 10.1042/BST20110626) (PMID:22260707)
Cameron, R.T. and Baillie, G.S. (2012) cAMP-specific phosphodiesterase: modulation, inhibition and activation. In: Botana, L.M. and Loza, M. (eds.) Therapeutic Targets: Modulation, Inhibition, and Activation. John Wiley & Sons Ltd: Hoboken, N.J.. ISBN 9780470587195
Edwards, H.V., Scott, J.D. and Baillie, G.S. (2012) The A-kinase-anchoring protein AKAP-Lbc facilitates cardioprotective PKA phosphorylation of Hsp20 on Ser16. Biochemical Journal, 446(3), pp. 437-443. (doi: 10.1042/BJ20120570)
Havekes, R., Choi, J.H., Bruinenberg, V., Baillie, G. , Park, A., Day, J., Aton, S., Meerlo, P., Houslay, M. and Abel, T. (2012) Blocking the phosphodiesterase isoform PDE4A5 in the hippocampus ameliorates plasticity and memory deficits induced by brief sleep deprivation. In: Annual Meeting of the Associated-Professional-Sleep-Societies (APSS), Boston, MA, USA, 9-13 June 2012, A94-A95.
Havekes, R., Choi, J.H., Bruinenberg, V., Baillie, G.S. , Park, A., Day, J., Anton, S., Meerlo, P., Houslay, M.D. and Abel, T. (2012) Cognitive impairments induced by brief sleep deprivation can be prevented by targeting a single phosphodiesterase isoform selectively in the hippocampus [abstract]. In: 42nd Annual Meeting of the Society-for-Neuroscience, New Orleans, Louisiana, USA, Oct 13 - Oct 17 2012,
Havekes, R., Choi, J.H., Bruinenberg, V., Baillie, G.S. , Park, A., Day, J., Anton, S., Meerlo, P., Houslay, M.D. and Abel, T. (2012) Gravin is a key scaffolding protein that orchestrates PKA and beta 2-adrenergic receptor signaling important for long-lasting forms of synaptic plasticity and long-term memory [abstract]. In: 42nd Annual Meeting of the Society for Neuroscience, New Orleans, Louisiana, USA, Oct 13 - Oct 17 2012,
2011
MacKenzie, K. F., Wallace, D. A., Hill, E. V., Anthony, D. F., Henderson, D. J.P., Houslay, D. M., Arthur, J. S. C., Baillie, G. S. and Houslay, M. D. (2011) Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation. Biochemical Journal, 435(3), pp. 755-769. (doi: 10.1042/BJ20101184)
Sin, Y.Y., Edwards, H.V., Li, X., Day, J.P., Christian, F. , Dunlop, A.J., Adams, D.R., Zaccolo, M., Houslay, M.D. and Baillie, G.S. (2011) Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)–HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes. Journal of Molecular and Cellular Cardiology, 50(5), pp. 872-883. (doi: 10.1016/j.yjmcc.2011.02.006) (PMID:21334344)
Christian, F. et al. (2011) Small molecule AKAP-protein kinase A (PKA) interaction disruptors that activate PKA interfere with compartmentalized cAMP signaling in cardiac myocytes. Journal of Biological Chemistry, 286(11), pp. 9079-9096. (doi: 10.1074/jbc.M110.160614) (PMID:21177871) (PMCID:PMC305896)
Day, J. P. et al. (2011) Elucidation of a structural basis for the inhibitor-driven, p62 (SQSTM1)-dependent intracellular redistribution of cAMP phosphodiesterase-4A4 (PDE4A4). Journal of Medicinal Chemistry, 54(9), pp. 3331-3347. (doi: 10.1021/jm200070e)
Anthony, D.F., Sin, Y.Y., Vadrevu, S., Advant, N., Day, J.P., Byrne, A.M., Lynch, M.J., Milligan, G. , Houslay, M.D. and Baillie, G.S. (2011) β-Arrestin 1 inhibits the GAP function of ARHGAP21 so as to promote the activation of RhoA following angiotensin II type 1A receptor stimulation. Molecular and Cellular Biology, 31(5), pp. 1066-1075. (doi: 10.1128/MCB.00883-10) (PMID:21173159) (PMCID:PMC3067824)
Edwards, H.V., Cameron, R.T. and Baillie, G.S. (2011) The emerging role of HSP20 as a multifunctional protective agent. Cellular Signalling, 23(9), pp. 1447-1454. (doi: 10.1016/j.cellsig.2011.05.009)
Kean, M. J. et al. (2011) Structure-Function Analysis of Core STRIPAK Proteins: A SIGNALING COMPLEX IMPLICATED IN GOLGI POLARIZATION. Journal of Biological Chemistry, 286(28), pp. 25065-25075. (doi: 10.1074/jbc.M110.214486)
Lima-Fernandes, E. et al. (2011) Distinct functional outputs of PTEN signalling are controlled by dynamic association with β-arrestins. EMBO Journal, 30(13), pp. 2557-2568. (doi: 10.1038/emboj.2011.178)
Perino, A. et al. (2011) Integrating cardiac PIP3 and cAMP signaling through a PKA anchoring function of p110γ. Molecular Cell, 42(1), pp. 84-95.
Reijns, M.A.M., Bubeck, D., Gibson, L.C.D., Graham, S.C., Baillie, G.S. , Jones, E.Y. and Jackson, A.P. (2011) The Structure of the Human RNase H2 Complex Defines Key Interaction Interfaces Relevant to Enzyme Function and Human Disease. Journal of Biological Chemistry, 286(12), pp. 10530-10539. (doi: 10.1074/jbc.M110.177394)
2010
Burton, P. et al. (2010) Erythro-9-(2-hydroxy-3-nonyl)adenine (EHNA) blocks differentiation and maintains the expression of pluripotency markers in human embryonic stem cells. Biochemical Journal, 432(3), pp. 575-584. (doi: 10.1042/BJ20100726)
Bird, R. J., Baillie, G. S. and Yarwood, S. J. (2010) Interaction with receptor for activated C-kinase 1 (RACK1) sensitizes the phosphodiesterase PDE4D5 towards hydrolysis of cAMP and activation by protein kinase C. Biochemical Journal, 432(1), pp. 207-216. (doi: 10.1042/BJ20101010)
Rampersad, S. N., Ovens, J. D., Huston, E., Umana, M. B., Wilson, L. S., Netherton, S. J., Lynch, M. J., Baillie, G. S. , Houslay, M. D. and Maurice, D. H. (2010) Cyclic AMP Phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a Vascular Endothelial Cadherin (VE-Cad)-based Signaling Complex and Controls cAMP-mediated Vascular Permeability. Journal of Biological Chemistry, 285(44), pp. 33614-33622. (doi: 10.1074/jbc.M110.140004)
Christian, F. , Anthony, D. F., Vadrevu, S., Riddell, T., Day, J. P., McLeod, R., Adams, D. R., Baillie, G. S. and Houslay, M. D. (2010) p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways. Cellular Signalling, 22(10), pp. 1576-1596. (doi: 10.1016/j.cellsig.2010.06.003)
Zhu, H. et al. (2010) Evolutionarily Conserved Role of Calcineurin in Phosphodegron-Dependent Degradation of Phosphodiesterase 4D. Molecular and Cellular Biology, 30(18), pp. 4379-4390. (doi: 10.1128/MCB.01193-09)
Burton, P. et al. (2010) Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells. Biochemical Society Transactions, 38(4), pp. 1058-1061. (doi: 10.1042/BST0381058)
Serrels, B., Sandilands, E., Serrels, A., Baillie, G. , Houslay, M. D., Brunton, V. G., Canel, M., Machesky, L. M. , Anderson, K. I. and Frame, M. C. (2010) A complex between FAK, RACK1, and PDE4D5 controls spreading initiation and cancer cell polarity. Current Biology, 20(12), pp. 1086-1092. (doi: 10.1016/j.cub.2010.04.042)
Li, X. et al. (2010) Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK. Biochemical Journal, 428(1), pp. 55-65. (doi: 10.1042/BJ20091672)
Bjorgo, E., Solheim, S. A., Abrahamsen, H., Baillie, G. S. , Brown, K. M., Berge, T., Okkenhaug, K., Houslay, M. D. and Tasken, K. (2010) Cross talk between phosphatidylinositol 3-kinase and cyclic AMP (cAMP)-protein kinase A signaling pathways at the level of a protein kinase B/β-Arrestin/cAMP phosphodiesterase 4 complex. Molecular and Cellular Biology, 30(7), pp. 1660-1672. (doi: 10.1128/MCB.00696-09)
Schafer, P.H. et al. (2010) Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis. British Journal of Pharmacology, 159(4), pp. 842-855. (doi: 10.1111/j.1476-5381.2009.00559.x)
Burton, P. et al. (2010) Identification and characterization of small-molecule ligands that maintain pluripotency of human embryonic stem cells. Biochemical Society Transactions, 38(4), pp. 1058-1061. (doi: 10.1042/BST0381058)
Xu, T. et al. (2010) Inferring signaling pathway topologies from multiple perturbation measurements of specific biochemical species. Science Signaling, 3(113), ra20. (doi: 10.1126/scisignal.2000517)
2009
Vecsey, C. G. et al. (2009) Sleep deprivation impairs cAMP signalling in the hippocampus. Nature, 461(7267), pp. 1122-1125. (doi: 10.1038/nature08488)
Li, X. et al. (2009) A scanning peptide array approach uncovers association sites within the JNK/βarrestin signalling complex. FEBS Letters, 583(20), pp. 3310-3316. (doi: 10.1016/j.febslet.2009.09.035)
Kiely, P. A., Baillie, G. S. , Barrett, R., Buckley, D. A., Adams, D. R., Houslay, M. D. and O'Connor, R. (2009) Phosphorylation of RACK1 on tyrosine 52 by c-Abl is required for IGF-I-mediated regulation of focal adhesion kinase (FAK). Journal of Biological Chemistry, 284, pp. 20263-20274. (doi: 10.1074/jbc.M109.017640) (PMID:19423701) (PMCID:PMC2740452)
Li, X., Baillie, G. S. and Houslay, M. D. (2009) Mdm2 directs the ubiquitination of β-arrestin-sequestered cAMP phosphodiesterase-4D5. Journal of Biological Chemistry, 284(24), pp. 16170-16182. (doi: 10.1074/jbc.M109.008078)
Ong, W.K., Gribble, F.M., Reimann, F., Lynch, M.J., Houslay, M.D., Baillie, G.S. , Furman, B.L. and Pyne, N.J. (2009) The role of the PDE4D cAMP phosphodiesterase in the regulation of glucagon-like peptide-1 release. British Journal of Pharmacology, 157(4), pp. 633-644. (doi: 10.1111/j.1476-5381.2009.00194.x)
Meng, D., Lynch, M. J., Huston, E., Beyermann, M., Eichhorst, J., Adams, D. R., Klusmann, E., Houslay, M. D. and Baillie, G. S. (2009) MEK1 binds directly to βArrestin1, influencing both its phosphorylation by ERK and the timing of its isoprenaline-stimulated internalization. Journal of Biological Chemistry, 284(17), pp. 11425-11435. (doi: 10.1074/jbc.M806395200) (PMID:19153083) (PMCID:PMC2670148)
Terrenoire, C., Houslay, M. D., Baillie, G. S. and Kass, R. S. (2009) The Cardiac IKs Potassium Channel Macromolecular Complex Includes the Phosphodiesterase PDE4D3. Journal of Biological Chemistry, 284(14), pp. 9140-9146. (doi: 10.1074/jbc.M805366200)
Baillie, G. S. (2009) Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases. FEBS Journal, 276(7), pp. 1790-1799. (doi: 10.1111/j.1742-4658.2009.06926.x)
2008
Collins, D. M., Murdoch, H., Dunlop, A. J., Charych, E., Baillie, G. S. , Wang, Q., Herberg, F. W., Brandon, N., Prinz, A. and Houslay, M. D. (2008) Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA). Cellular Signalling, 20(12), pp. 2356-2369. (doi: 10.1016/j.cellsig.2008.09.017)
McCahill, A., Campbell, L., McSorley, T., Lynch, M. J., Li, X., Yang, C., Baillie, G. S. , Houslay, M. D. and Sood, A. (2008) In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10). Cellular Signalling, 20(11), pp. 2071-2083. (doi: 10.1016/j.cellsig.2008.07.017)
Di Benedetto, G., Zoccarato, A., Lissandron, V., Terrin, A., Li, X., Houslay, M. D., Baillie, G. S. and Zaccolo, M. (2008) Protein kinase A type I and type II define distinct intracellular signaling compartments. Circulation Research, 103(8), pp. 836-844. (doi: 10.1161/CIRCRESAHA.108.174813)
Huston, E., Lynch, M. J., Mohamed, A., Collins, D. M., Hill, E. V., McLeod, R., Krause, E., Baillie, G. S. and Houslay, M. D. (2008) EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation. Proceedings of the National Academy of Sciences of the United States of America, 105(35), pp. 12791-12796. (doi: 10.1073/pnas.0805167105)
Kiely, P. A., Baillie, G. S. , Lynch, M. J., Houslay, M. D. and O'Connor, R. (2008) Tyrosine 302 in RACK1 is essential for insulin-like growth factor-I-mediated competitive binding of PP2A and {beta}1 integrin and for tumor cell proliferation and migration. Journal of Biological Chemistry, 283(34), pp. 22952-22961. (doi: 10.1074/jbc.M800802200)
Xu, T.-R., Baillie, G. S. , Bhari, N., Houslay, T. M., Pitt, A. M., Adams, D. R., Kolch, W., Houslay, M. D. and Milligan, G. (2008) Mutations of β-arrestin 2 that limit self-association also interfere with interactions with the β2-adrenoceptor and the ERK1/2 MAPKs: implications for β2-adrenoceptor signalling via the ERK1/2 MAPKs. Biochemical Journal, 413(1), pp. 51-60. (doi: 10.1042/BJ20080685)
Mackenzie, K. F. et al. (2008) Human PDE4A8, a novel brain-expressed PDE4 cAMP-specific phosphodiesterase that has undergone rapid evolutionary change. Biochemical Journal, 411(2), pp. 361-369. (doi: 10.1042/BJ20071251)
2007
Smith, K. J. et al. (2007) 1H NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, βarrestin and RACK1. Cellular Signalling, 19(12), pp. 2612-2624. (doi: 10.1016/j.cellsig.2007.08.015)
Houslay, M. D., Lynch, M. J. and Baillie, G. S. (2007) cAMP-specific phosphodiesterase-4D5 (PDE4D5) provides a paradigm for understanding the unique non-redundant roles that PDE4 isoforms play in shaping compartmentalized cAMP cell signalling. Biochemical Society Transactions, 35(5), pp. 938-941. (doi: 10.1042/BST0350938)
Sachs, B.D. et al. (2007) p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway. Journal of Cell Biology, 177(6), pp. 1119-1132. (doi: 10.1083%2Fjcb.200701040)
Baillie, G.S. et al. (2007) Mapping binding sites for the PDE4D5 cAMP-specific phosphodiesterase to the N- and C-domains of beta-arrestin using spot-immobilized peptide arrays. Biochemical Journal, 404(1), pp. 71-80. (doi: 10.1042%2FBJ20070005)
Cheung, Y., Kan, Z., Garrett-Engele, P., Gall, I., Murdoch, H., Baillie, G. , Camargo, L., Johnson, J., Houslay, M. and Castle, J. (2007) PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6). Journal of Pharmacology and Experimental Therapeutics, 322, pp. 600-609. (doi: 10.1124/jpet.107.122218)
Houslay, M., Baillie, G. and Maurice, D. (2007) cAMP-specific phosphodiesterase-4 enzymes in the cardiovascular system - A molecular toolbox for generating compartmentalized cAMP signaling. Circulation Research, 100, pp. 950-966. (doi: 10.1161/01.RES.0000261934.56938.38)
McEwan, D., Brunton, V., Baillie, G. , Leslie, N., Houslay, M. and Frame, M. (2007) Chemoresistant KM12C colon cancer cells are addicted to low cyclic AMP levels in a phosphodiesterase 4-regulated compartment via effects on phosphoinositide 3-kinase. Cancer Research, 67, pp. 5248-5257. (doi: 10.1158/0008-5472.CAN-07-0097)
Smith, K. et al. (2007) H-1 NMR structural and functional characterisation of a cAMP-specific phosphodiesterase-4D5 (PDE4D5) N-terminal region peptide that disrupts PDE4D5 interaction with the signalling scaffold proteins, arrestin and RACK1. Cellular Signalling, 19, pp. 2612-2624. (doi: 10.1016/j.cellsig.2007.08.015)
Stefan, E. et al. (2007) Compartmentalization of cAMP-dependent signaling by phosphodiesterase-4D is involved in the regulation of vasopressin-mediated water reabsorption in renal principal cells. Journal of the American Society of Nephrology, 18, pp. 199-212. (doi: 10.1681/ASN.2006020132)
Willoughby, D., Baillie, G. , Lynch, M., Ciruela, A., Houslay, M. and Cooper, D. (2007) Dynamic regulation, desensitization, and cross-talk in discrete subcellular microdomains during beta(2)-adrenoceptor and prostanoid receptor cAMP signaling. Journal of Biological Chemistry, 282, pp. 34235-34249. (doi: 10.1074/jbc.M706765200)
2006
Gronning, L. M., Baillie, G. S. , Cederberg, A., Lynch, M. J., Houslay, M. D., Enerback, S. and Tasken, K. (2006) Reduced PDE4 expression and activity contributes to enhanced catecholamine-induced cAMP accumulation in adipocytes from FOXC2 transgenic mice. FEBS Letters, 580(17), pp. 4126-4130. (doi: 10.1016/j.febslet.2006.06.058)
Bolger, G.B. et al. (2006) Scanning peptide array analysis identify overlapping binding sites for the signaling scaffold proteins, beta-arestin and RACK1 in the cAMP-specific phosphodiesterase, PDE4D5. Biochemical Journal, 398(1), pp. 23-36. (doi: 10.1042/BJ20060423)
Hayavi, S., Baillie, G. , Owens, M. and Halbert, G. (2006) Receptor dependent cellular uptake of synthetic low density lipoprotein by mammalian cells in serum-free tissue culture. Journal of Pharmacy and Pharmacology, 58, pp. 1337-1342. (doi: 10.1211/jpp.58.10.0006)
Houslay, M. and Baillie, G. (2006) Phosphodiesterase-4 gates the ability of protein kinase A to phosphorylate G-protein receptor kinase-2 and influence its translocation. Biochemical Society Transactions, 34, pp. 474-475.
Huston, E., Houslay, T., Baillie, G. and Houslay, M. (2006) cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling. Biochemical Society Transactions, 34, pp. 504-509.
Li, X., Huston, E., Lynch, M., Houslay, M. and Baillie, G. (2006) Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293 beta 2 cells and cardiac myocytes. Biochemical Journal, 394, pp. 427-435. (doi: 10.1042/BJ20051560)
McSorley, T., Stefan, E., Henn, V., Wiesner, B., Baillie, G. , Houslay, M., Rosenthal, W. and Klussmann, E. (2006) Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells. European Journal of Cell Biology, 85, pp. 673-678. (doi: 10.1016/j.ejcb.2006.01.005)
Terrin, A. et al. (2006) PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases. Journal of Cell Biology, 175, pp. 441-451. (doi: 10.1083/jcb.200605050)
2005
Baillie, G. S. , Scott, J. D. and Houslay, M. D. (2005) Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract. FEBS Letters, 579(15), pp. 3264-3270. (doi: 10.1016/j.febslet.2005.03.089)
Baillie, G. and Houslay, M. (2005) Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes. Current Opinion in Cell Biology, 17, pp. 129-134. (doi: 10.1016/j.ceb.2005.01.003)
Henn, V., Stefan, E., Baillie, G. , Houslay, M., Rosenthal, W. and Klussmann, E. (2005) Compartmentalized cAMP signalling regulates vasopressin-mediated water reabsorption by controlling aquaporin-2. Biochemical Society Transactions, 33, pp. 1316-1318.
Hill, E.V., Houslay, M.D. and Baillie, G.S. (2005) Investigation of extracellular signal-regulated kinase 2 mitogen-activated protein kinase phosphorylation and regulation of activity of PDE4 cyclic adenosine monophosphate-specific phosphodiesterases. Methods in Molecular Biology, 307, pp. 225-238. (doi: 10.1385/1-59259-839-0:225)
Houslay, M. and Baillie, G. (2005) beta-Arrestin-recruited phosphodiesterase-4 desensitizes the AKAP79/PKA-mediated switching of beta(2)-adrenoceptor signalling to activation of ERK. Biochemical Society Transactions, 33, pp. 1333-1336.
Lynch, M., Baillie, G. , Mohamed, A., Li, X., Maisonneuve, C., Klussmann, E., van Heeke, G. and Houslay, M. (2005) RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta(2)-adrenergic receptor to activation of ERK in HEK293B2 cells. Journal of Biological Chemistry, 280, pp. 33178-33189. (doi: 10.1074/jbc.M414316200)
Millar, J. et al. (2005) DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science, 310, pp. 1187-1191. (doi: 10.1126/science.1112915)
2004
Abrahamsen, H., Baillie, G. , Ngai, J., Vang, T., Nika, K., Ruppelt, A., Mustelin, T., Zaccolo, M., Houslay, M. and Tasken, K. (2004) TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling. Journal of Immunology, 173, pp. 4847-4858.
Barber, R., Baillie, G.S. , Bergmann, R., Shepherd, M.C., Sepper, R., Houslay, M.D. and Van Heeke, G. (2004) Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers. American Journal of Physiology: Lung Cellular and Molecular Physiology, 287, L332-L343. (doi: 10.1152/ajplung.00384.2003)
Johnston, L. et al. (2004) Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene. Biochemical Journal, 380, pp. 371-384.
Shepherd, M., Baillie, G. , Stirling, D. and Houslay, M. (2004) Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells. British Journal of Pharmacology, 142, pp. 339-351. (doi: 10.1038/sj.bjp.0705770)
2003
Baillie, G. , Sood, A., McPhee, I., Gall, I., Perry, S., Lefkowitz, R. and Houslay, M. (2003) β-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates β-adrenoceptor switching from Gs to Gi. Proceedings of the National Academy of Sciences of the United States of America, 100(3), pp. 940-945. (doi: 10.1073/pnas.262787199)
Bolger, G., McCahill, A., Huston, E., Cheung, Y., McSorley, T., Baillie, G. and Houslay, M. (2003) The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins. Journal of Biological Chemistry, 278, pp. 49230-49238. (doi: 10.1074/jbc.M303772200)
Bolger, G., Peden, A., Steele, M., MacKenzie, C., McEwan, D., Wallace, D., Huston, E., Baillie, G. and Houslay, M. (2003) Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2. Journal of Biological Chemistry, 278, pp. 33351-33363. (doi: 10.1074/jbc.M303269200)
Houslay, M. and Baillie, G. (2003) The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways. Biochemical Society Transactions, 31, pp. 1186-1190.
Shepherd, M., McSorley, T., Olsen, A., Johnston, L., Thomson, N., Baillie, G. , Houslay, M. and Bolger, G. (2003) Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform. Biochemical Journal, 370, pp. 429-438.
Terry, R., Cheung, Y., Praestegaard, M., Baillie, G. , Huston, E., Gall, I., Adams, D. and Houslay, M. (2003) Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process. Cellular Signalling, 15, pp. 955-971. (doi: 10.1016/S0898-6568(03)00092-5)
2002
Adam, B., Baillie, G. and Douglas, L. (2002) Mixed species biofilms of Candida albicans and Staphylococcus epidermidis. Journal of Medical Microbiology, 51, pp. 344-349.
Baillie, G. (2002) A synthetic low density lipoprotein particle capable of supporting U937 proliferation in vitro. Journal of Lipid Research, 43(1), pp. 69-73.
Baillie, G. et al. (2002) TAPAS-1, a novel microdomaln within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid. Journal of Biological Chemistry, 277, pp. 28298-28309. (doi: 10.1074/jbc.M108353200)
MacKenzie, S., Baillie, G. , McPhee, I., MacKenzie, C., Seamons, R., McSorley, T., Millen, J., Beard, M., van Heeke, G. and Houslay, M. (2002) Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1). British Journal of Pharmacology, 136, pp. 421-433.
Perry, S. et al. (2002) Targeting of cyclic AMP degradation to beta(2)-adrenergic receptors by beta-arrestins. Science, 298, pp. 834-836.
2001
Baillie, G. , MacKenzie, S. and Houslay, M. (2001) Phorbol 12-myristate 13-acetate triggers the protein kinase A-mediated phosphorylation and activation of the PDE4D5 cAMP phosphodiesterase in human aortic smooth muscle cells through a route involving extracellular signal regulated kinase (ERK). Molecular Pharmacology, 60, pp. 1100-1111.
Baillie, G. (2001) Physicochemical properties of microemulsion analogues of low density lipoprotein containing amphiphatic apoprotein B receptor sequences. International Journal of Pharmaceutics, 228(39479), pp. 109-117. (doi: 10.1016/S0378-5173(01)00818-3)
Articles
Cooke, S. F. et al. (2024) Disruption of the pro-oncogenic c-RAF–PDE8A complex represents a differentiated approach to treating KRAS–c-RAF dependent PDAC. Scientific Reports, 14, 8998. (doi: 10.1038/s41598-024-59451-3) (PMID:38637546)
Sin, Y. Y. et al. (2024) Beta-amyloid associates directly with PDE4D5 to activate the enzyme and reduce cAMP availability. FEBS Letters, (Accepted for Publication)
Gulliver, C., Busiau, T., Byrne, A., Findlay, J. E., Hoffmann, R. and Baillie, G. (2023) cAMP-phosphodiesterase 4D7 (PDE4D7) forms a cAMP signalosome complex with DHX9 and is implicated in prostate cancer progression. Molecular Oncology, (doi: 10.1002/1878-0261.13572) (PMID:38126155) (Early Online Publication)
Gulliver, C., Baillie, G. S. and Hoffmann, R. (2023) Reduced PDE4D7 in prostate cancer correlates with genomic downregulation within the upstream PDE4D coding region. Future Science OA, 9(9), (doi: 10.2144/fsoa-2023-0064) (PMID:37752916) (PMCID:PMC10518809)
Parsons, E. C. , Baillie, G. S. and Hoffmann, R. (2023) Revisiting the roles of cAMP signalling in the progression of prostate cancer. Biochemical Journal, 480(20), pp. 1599-1614. (doi: 10.1042/BCJ20230297)
Gulliver, C., Huss, S., Semjonow, A., Baillie, G. S. and Hoffmann, R. (2023) Loss of PDE4D7 expression promotes androgen independence, neuroendocrine differentiation, and alterations in DNA repair: implications for therapeutic strategies. British Journal of Cancer, (doi: 10.1038/s41416-023-02417-5) (PMID:37740039) (Early Online Publication)
Wright, T. A., Gemmell, A. O., Tejeda, G. S. , Blair, C. M. and Baillie, G. S. (2023) Cancer: phosphodiesterase type 4C (PDE4C), the forgotten subfamily as a therapeutic target. International Journal of Biochemistry and Cell Biology, 162, 106453. (doi: 10.1016/j.biocel.2023.106453) (PMID:37499270)
Zorn, A. and Baillie, G. (2023) Phosphodiesterase 7 as a therapeutic target – Where are we now? Cellular Signalling, 108, 110689. (doi: 10.1016/j.cellsig.2023.110689) (PMID:37120115)
Kyurkchieva, E. and Baillie, G. S. (2023) Short PDE4 isoforms as drug targets in disease. Frontiers in Bioscience: Landmark, 28(7), 133. (doi: 10.31083/j.fbl2807133) (PMID:37525918)
Paes, D. et al. (2023) Ablation of specific long PDE4D isoforms increases neurite elongation and conveys protection against amyloid-β pathology. Cellular and Molecular Life Sciences, 80(7), 178. (doi: 10.1007/s00018-023-04804-w) (PMID:37306762) (PMCID:PMC10261250)
Brown, A. D., Vergunst, K. L., Branch, M., Blair, C. M., Dupré, D. J., Baillie, G. S. and Langelaan, D. N. (2023) Structural basis of CBP/p300 recruitment by the microphthalmia-associated transcription factor. Biochimica et Biophysica Acta: Molecular Cell Research, (doi: 10.1016/j.bbamcr.2023.119520) (PMID:37353163) (In Press)
Gulliver, C., Huss, S., Semjonow, A., Baillie, G. S. and Hoffmann, R. (2023) The CAPRA&PDE4D5/7/9 prognostic model is significantly associated to adverse post-surgical pathology outcomes. Cancers, 15(1), 262. (doi: 10.3390/cancers15010262) (PMID:36612262) (PMCID:PMC9818961)
Main, A. et al. (2022) Dynamic but discordant alterations in zDHHC5 expression and palmitoylation of its substrates in cardiac pathologies. Frontiers in Physiology, 13, 1023237. (doi: 10.3389/fphys.2022.1023237) (PMID:36277202) (PMCID:PMC9581287)
Fertig, B. et al. (2022) SUMOylation does not affect cardiac troponin I stability but alters indirectly the development of force in response to Ca2+. FEBS Journal, 289(20), pp. 6267-6285. (doi: 10.1111/febs.16537) (PMID:35633070) (PMCID:PMC9588612)
Stathopoulou, K. et al. (2022) CMYA5 is a novel interaction partner of FHL2 in cardiac myocytes. FEBS Journal, 289(15), pp. 4622-4645. (doi: 10.1111/febs.16402) (PMID:35176204)
Gulliver, C., Hoffmann, R. and Baillie, G. S. (2022) Ataxia-telangiectasia mutated and ataxia telangiectasia and Rad3-related kinases as therapeutic targets and stratification indicators for prostate cancer. International Journal of Biochemistry and Cell Biology, 147, 106230. (doi: 10.1016/j.biocel.2022.106230) (PMID:35609768)
Tibbo, A. J. et al. (2022) Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins. Journal of Molecular and Cellular Cardiology, 165, pp. 86-102. (doi: 10.1016/j.yjmcc.2022.01.001) (PMID:34999055) (PMCID:PMC8986152)
Mahindra, A. et al. (2021) Peptides derived from the SARS-CoV-2 receptor binding motif bind to ACE2 but do not block ACE2-mediated host cell entry or pro-inflammatory cytokine induction. PLoS ONE, 16(11), e0260283. (doi: 10.1371/journal.pone.0260283) (PMID:34793553) (PMCID:PMC8601423)
Buist, H. K. et al. (2021) Identification and characterization of an affimer affinity reagent for the detection of the cAMP sensor, EPAC1. Cells, 10(9), 2307. (doi: 10.3390/cells10092307)
Morgan, D. C. et al. (2021) Stapled ACE2 peptidomimetics designed to target the SARS-CoV-2 spike protein do not prevent virus internalisation. Peptide Science, 113(4), e24217. (doi: 10.1002/pep2.24217) (PMID:33615115) (PMCID:PMC7883042)
Scott, M. et al. (2021) The RanBP2/RanGAP1-SUMO complex gates β-arrestin2 nuclear entry to regulate the Mdm2-p53 signalling axis. Oncogene, 40(12), pp. 2243-2257. (doi: 10.1038/s41388-021-01704-w) (PMID:33649538)
Baillie, G. S. , Gulliver, C. and Hoffmann, R. (2021) The enigmatic helicase DHX9 and its association with the hallmarks of cancer. Future Science OA, 7(2), FSO650. (doi: 10.2144/fsoa-2020-0140) (PMID:33437516) (PMCID:PMC7787180)
Main, A., Fuller, W. and Baillie, G. S. (2020) Post-translational regulation of cardiac myosin binding protein-C: a graphical review. Cellular Signalling, 76, 109788. (doi: 10.1016/j.cellsig.2020.109788) (PMID:32976931)
Zou, Z.-G. et al. (2020) Epidermal growth factor signaling through transient receptor potential melastatin 7 cation channel regulates vascular smooth muscle cell function. Clinical Science, 134(15), pp. 2019-2035. (doi: 10.1042/CS20200827) (PMID:32706027) (PMCID:PMC8299307)
Gök, C. , Plain, F., Robertson, A., Howie, J., Baillie, G. S. , Fraser, N. J. and Fuller, W. (2020) Dynamic palmitoylation of the sodium-calcium exchanger modulates its structure, affinity for lipid ordered domains, and inhibition by XIP. Cell Reports, 31(10), 107697. (doi: 10.1016/j.celrep.2020.107697) (PMID:32521252) (PMCID:PMC7296346)
Ling, J., Blair, C. M. and Baillie, G. S. (2020) Fibrin Breakdown Assay. Bio-Protocol, 10(8), e3585. (doi: 10.21769/BioProtoc.3585)
Blair, C. M., Ling, J. and Baillie, G. S. (2020) Measuring cAMP specific phosphodiesterase activity: a two-step radioassay. Bio-Protocol, 10(7), e3581. (doi: 10.21769/BioProtoc.3581) (PMID:33659551) (PMCID:PMC7842805)
Lochhead, M. R., Brown, A. D., Kirlin, A. C., Chitayat, S., Munro, K., Findlay, J. E., Baillie, G. S. , LeBrun, D. P., Langelaan, D. N. and Smith, S. P. (2020) Structural insights into TAZ2 domain-mediated CBP/p300 recruitment by transactivation domain 1 of the lymphopoietic transcription factor E2A. Journal of Biological Chemistry, 27, pp. 4303-4315. (doi: 10.1074/jbc.RA119.011078) (PMID:32098872)
Tejeda, G. S. , Whiteley, E. L., Deeb, T. Z., Bürli, R. W., Moss, S. J., Sheridan, E., Brandon, N. J. and Baillie, G. S. (2020) Chorea-related mutations in PDE10A result in aberrant compartmentalization and functionality of the enzyme. Proceedings of the National Academy of Sciences of the United States of America, 117(1), pp. 677-688. (doi: 10.1073/pnas.1916398117) (PMID:31871190) (PMCID:PMC6955301)
Baillie, G. and Tibbo, A. (2020) Phosphodiesterase 4B: master regulator of brain signaling. Cells, 9(5), 1254. (doi: 10.3390/cells9051254) (PMID:32438615) (PMCID:PMC7291338)
Baillie, G. S. , Tejeda, G. S. and Kelly, M. P. (2019) Therapeutic targeting of 3’,5’-cyclic nucleotide phosphodiesterases: inhibition and beyond. Nature Reviews Drug Discovery, 18, pp. 770-796. (doi: 10.1038/s41573-019-0033-4) (PMID:31388135)
Blair, C. M. and Baillie, G. S. (2019) Reshaping cAMP nanodomains through targeted disruption of compartmentalised phosphodiesterase signalosomes. Biochemical Society Transactions, 47(5), pp. 1405-1414. (doi: 10.1042/BST20190252) (PMID:31506329)
Tibbo, A. J., Tejeda, G. S. and Baillie, G. S. (2019) Understanding PDE4's function in Alzheimer's disease; a target for novel therapeutic approaches. Biochemical Society Transactions, 47(5), pp. 1557-1565. (doi: 10.1042/BST20190763) (PMID:31642904) (PMCID:PMC6824677)
Whiteley, E. L., Tejeda, G. S. , Baillie, G. S. and Brandon, N. J. (2019) PDE10A mutations help to unwrap the neurobiology of hyperkinetic disorders. Cellular Signalling, 60, pp. 31-38. (doi: 10.1016/j.cellsig.2019.04.001) (PMID:30951862)
Omar, F. et al. (2019) Small-molecule allosteric activators of PDE4 long form cyclic AMP phosphodiesterases. Proceedings of the National Academy of Sciences of the United States of America, 116(27), pp. 13320-13329. (doi: 10.1073/pnas.1822113116) (PMID:31209056) (PMCID:PMC6613170)
Houslay, K.F., Fertig, B.A., Christian, F., Tibbo, A.J., Ling, J., Findlay, J.E., Houslay, M.D. and Baillie, G.S. (2019) Phosphorylation of PDE4A5 by MAPKAPK2 attenuates fibrin degradation via p75 signalling. Journal of Biochemistry, 166(1), pp. 97-106. (doi: 10.1093/jb/mvz016) (PMID:30859186) (PMCID:PMC6607969)
Wongpiyabovorn, J. et al. (2019) Effect of tarcolimus on skin microbiome in atopic dermatitis. Allergy, 74(7), pp. 1400-1406. (doi: 10.1111/all.13743) (PMID:30742708)
Clister, T., Greenwald, E. C., Baillie, G. S. and Zhang, J. (2019) AKAP95 organizes a nuclear microdomain to control local cAMP for regulating nuclear PKA. Cell Chemical Biology, 26(6), pp. 885-891. (doi: 10.1016/j.chembiol.2019.03.003) (PMID:30982750)
Van Strijp, D., De Witz, C., Heitkoetter, B., Huss, S., Boegemann, M., Baillie, G. S. , Houslay, M. D., Bangma, C., Semjonow, A. and Hoffmann, R. (2019) The association of the long prostate cancer expressed PDE4D transcripts to poor patient outcome depends on the tumor’s TMPRSS2-ERG fusion status. Prostate Cancer, 2019, 8107807. (doi: 10.1155/2019/8107807)
Vagena, E., Ryu, J. K., Baeza-Raja, B., Walsh, N. M., Syme, C., Day, J. P., Houslay, M. and Baillie, G. (2019) A high-fat diet promotes depression-like behavior in mice by suppressing hypothalamic PKA signalling. Translational Psychiatry, 9(1), 141. (doi: 10.1038/s41398-019-0470-1) (PMID:31076569) (PMCID:PMC6510753)
Blair, C. M., Walsh, N., Littman, B. H., Marcoux, F. W. and Baillie, G. S. (2019) Targeting B-Raf inhibitor resistant melanoma with novel cell penetrating peptide disrupters of PDE8A – C-Raf. BMC Cancer, 19, 266. (doi: 10.1186/s12885-019-5489-4) (PMID:30909892) (PMCID:PMC6434832)
Strembitska, A., Mancini, S. J., Gamwell, J. M., Palmer, T. M., Baillie, G. S. and Salt, I. P. (2018) A769662 inhibits insulin-stimulated Akt activation in human macrovascular endothelial cells independent of AMP-activated protein kinase. International Journal of Molecular Sciences, 19(12), 3886. (doi: 10.3390/ijms19123886) (PMID:30563079) (PMCID:PMC6321332)
Maziarz, M., Broselid, S., DiGiacomo, V., Park, J.-C., Luebbers, A., Garcia-Navarrete, L., Blanco-Canosa, J. B., Baillie, G. S. and Garcia-Marcos, M. (2018) A biochemical and genetic discovery pipeline identifies PLCδ4b as a non-receptor activator of heterotrimeric G proteins. Journal of Biological Chemistry, 293(44), pp. 16964-16983. (doi: 10.1074/jbc.RA118.003580) (PMID:30194280) (PMCID:PMC6222092)
Elliott, C. et al. (2018) A role for APP in Wnt signalling links synapse loss with β-amyloid production. Translational Psychiatry, 8, 179. (doi: 10.1038/s41398-018-0231-6) (PMID:30232325) (PMCID:PMC6145937)
Engelhardt, B., Holze, J., Elliott, C. , Baillie, G.S. , Kschischo, M. and Fröhlich, H. (2018) Modelling and mathematical analysis of the M2 receptor-dependent joint signalling and secondary messenger network in CHO cells. Mathematical Medicine and Biology, 35(3), pp. 279-297. (doi: 10.1093/imammb/dqx003) (PMID:28505258)
Daly, J. P., Whiteley, E., Freeley, M., Long, A., Malacrida, B., Kiely, P. and Baillie, G. S. (2018) RAB40C regulates RACK1 stability via the ubiquitin-proteasome system. Future Science OA, 4(7), FSO317. (doi: 10.4155/fsoa-2018-0022) (PMID:30112187) (PMCID:PMC6088270)
van Strijp, D. et al. (2018) The prognostic PDE4D7 score in a diagnostic biopsy prostate cancer patient cohort with longitudinal biological outcomes. Prostate Cancer, 2018, 5821616. (doi: 10.1155/2018/5821616) (PMID:30147955) (PMCID:PMC6083737)
de Inda, M. A. et al. (2018) Validation of cyclic adenosine monophosphate phosphodiesterase-4D7 for its independent contribution to risk stratification in a prostate cancer patient cohort with longitudinal biological outcomes. European Urology Focus, 4(3), pp. 376-384. (doi: 10.1016/j.euf.2017.05.010) (PMID:28753810)
Sellers, K. J. et al. (2018) Amyloid β synaptotoxicity is Wnt-PCP dependent and blocked by fasudil. Alzheimer's and Dementia, 14(3), pp. 306-317. (doi: 10.1016/j.jalz.2017.09.008) (PMID:29055813) (PMCID:PMC5869054)
Fertig, B. A. and Baillie, G. S. (2018) PDE4-mediated cAMP signalling. Journal of Cardiovascular Development and Disease, 5(1), 8. (doi: 10.3390/jcdd5010008)
Williams, J. J.L., Al-Otaiq, N., Mullen, W. , Burchmore, R. , Liu, L., Baillie, G. S. , Schaper, F., Pilch, P. F. and Palmer, T. M. (2018) Interaction of suppressor of cytokine signalling 3 with cavin-1 links SOCS3 function and cavin-1 stability. Nature Communications, 9, 168. (doi: 10.1038/s41467-017-02585-y) (PMID:29330478) (PMCID:PMC5766592)
Rodrigues, A. L., Brescia, M., Kolshinski, A., Moreira, T. H., Cameron, R. T., Baillie, G. , Beirão, P. S.L., Zaccollo, M. and Cruz, J. S. (2018) Increase in Ca2+ current by sustained cAMP levels enhances proliferation rate in GH3 cells. Life Sciences, 192, pp. 144-150. (doi: 10.1016/j.lfs.2017.11.040) (PMID:29183797)
Yalla, K. et al. (2018) FBXW7 regulates DISC1 stability via the ubiquitin-proteosome system. Molecular Psychiatry, 23(5), pp. 1278-1286. (doi: 10.1038/mp.2017.138) (PMID:28727686) (PMCID:PMC5984089)
Basole, C. P., Nguyen, R. K., Lamothe, K., Vang, A., Clark, R., Baillie, G. S. , Epstein, P. M. and Brocke, S. (2017) PDE8 controls CD4(+) T cell motility through the PDE8A-Raf-1 kinase signaling complex. Cellular Signalling, 40, pp. 62-72. (doi: 10.1016/j.cellsig.2017.08.007) (PMID:28851628)
Lemonidis, K., MacLeod, R., Baillie, G. S. and Chamberlain, L. H. (2017) Peptide array based screening reveals a large number of proteins interacting with the ankyrin repeat domain of the zDHHC17 S-acyltransferase. Journal of Biological Chemistry, 292(42), pp. 17190-17202. (doi: 10.1074/jbc.M117.799650)
Kiely, M., Adams, D. R., Hayes, S. L., O'Connor, R., Baillie, G. S. and Kiely, P. A. (2017) RACK1 stabilises the activity of PP2A to regulate the transformed phenotype in mammary epithelial cells. Cellular Signalling, 35, pp. 290-300. (doi: 10.1016/j.cellsig.2016.09.001) (PMID:27600565)
Nishi, K., Luo, H., Ishikura, S., Doi, K., Iwaihara, Y., Wills, L., Baillie, G. S. , Sakata, T., Shirasawa, S. and Tsunoda, T. (2017) Apremilast induces apoptosis of human colorectal cancer cells with mutant KRAS. Anticancer Research, 37(7), pp. 3833-3839. (doi: 10.21873/anticanres.11762) (PMID:28668883)
Ibáñez de Opakua, A. et al. (2017) Molecular mechanism of Gαi activation by non-GPCR proteins with a Gα-Binding and Activating motif. Nature Communications, 8, 15163. (doi: 10.1038/ncomms15163) (PMID:28516903) (PMCID:PMC5454376)
Diamantopoulou, Z. et al. (2017) TIAM1 antagonizes TAZ/YAP both in the destruction complex in the cytoplasm and in the nucleus to inhibit invasion of intestinal epithelial cells. Cancer Cell, 31(5), pp. 621-634. (doi: 10.1016/j.ccell.2017.03.007) (PMID:28416184) (PMCID:PMC5425402)
Monterisi, S. et al. (2017) PDE2A2 regulates mitochondria morphology and apoptotic cell death via local modulation of cAMP/PKA signalling. eLife, 6, e21374. (doi: 10.7554/eLife.21374) (PMID:28463107) (PMCID:PMC5423767)
Schoenherr, C., Byron, A., Sandilands, E., Paliashvili, K., Baillie, G. S. , Valacca, C., Cecconi, F., Serrels, B. and Frame, M. C. (2017) Ambra1 spatially regulates Src activity and Src/FAK-mediated cancer cell invasion via trafficking networks. eLife, 6, e23172. (doi: 10.7554/eLife.23172) (PMID:28362576)
Houslay, K. F., Christian, F. , MacLeod, R., Adams, D. R., Houslay, M. D. and Baillie, G. S. (2017) Identification of a multifunctional docking site on the catalytic unit of phosphodiesterase-4 (PDE4) that is utilised by multiple interaction partners. Biochemical Journal, 474(4), pp. 597-609. (doi: 10.1042/BCJ20160849) (PMID:27993970) (PMCID:PMC5290487)
Deschamps, T. et al. (2017) Epstein-Barr virus nuclear antigen 1 interacts with regulator of chromosome condensation 1 dynamically throughout the cell cycle. Journal of General Virology, 98(2), pp. 251-265. (doi: 10.1099/jgv.0.000681) (PMID:28284242)
Cameron, R. T., Whiteley, E., Day, J. P., Parachikova, A. I. and Baillie, G. S. (2017) Selective inhibition of phosphodiesterases 4, 5 and 9 induces HSP20 phosphorylation and attenuates amyloid beta 1-42 mediated cytotoxicity. FEBS Open Bio, 7(1), pp. 64-73. (doi: 10.1002/2211-5463.12156) (PMID:28097089) (PMCID:PMC5221464)
Javadi, A., Deevi, R. K., Evergren, E., Blondel-Tepaz, E., Baillie, G. S. , Scott, M. G.H. and Campbell, F. C. (2017) PTEN controls glandular morphogenesis through a juxtamembrane β-Arrestin1/ARHGAP21 scaffolding complex. eLife, 6, e24578. (doi: 10.7554/eLife.24578) (PMID:28749339) (PMCID:PMC5576923)
Rutherford, C. et al. (2016) Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling. Science Signaling, 9(453), ra109. (doi: 10.1126/scisignal.aaf8566) (PMID:27919027)
Böttcher, R., Dulla, K., van Strijp, D., Dits, N., Verhoef, E. I., Baillie, G. S. , Van Leenders, G. J.L.H., Houslay, M. D., Jenster, G. and Hoffmann, R. (2016) Human PDE4D isoform composition is deregulated in primary prostate cancer and indicative for disease progression and development of distant metastases. Oncotarget, 7(43), pp. 70669-70684. (doi: 10.18632/oncotarget.12204) (PMID:27683107) (PMCID:PMC5342582)
Yun, S., Budatha, M., Dahlman, J. E., Coon, B. G., Cameron, R. T., Langer, R., Anderson, D. G., Baillie, G. and Schwartz, M. A. (2016) Interaction between integrin α5 and PDE4D regulates endothelial inflammatory signalling. Nature Cell Biology, 18(10), pp. 1043-1053. (doi: 10.1038/ncb3405) (PMID:27595237) (PMCID:PMC5301150)
Hood, K. Y., Yusuf, H., Findlay, J. E., Santos, R. A., Castro, C. H., Baillie, G. S. , MacLean, M. R., Montezano, A. and Touyz, R. M. (2016) Ang(1-7) influences ET-1 signaling through Mas: ETBR interactions: implications in pulmonary hypertension. Journal of Hypertension, 34(Supl 1), e216. (doi: 10.1097/01.hjh.0000500475.07008.db) (PMID:27754060)
Hood, K. Y., Yusuf, H., Findlay, J. E., Santos, R. A., Castro, C. H., Baillie, G. S. , Montezano, A. C., MacLean, M. R. and Touyz, R. M. (2016) ANG-(1-7) and ET-1, a new partnership. Journal of Hypertension, 34, e382. (doi: 10.1097/01.hjh.0000500977.99529.fe) (PMID:27754197)
Havekes, R. et al. (2016) Compartmentalized PDE4A5 signaling impairs hippocampal synaptic plasticity and long-term memory. Journal of Neuroscience, 36(34), pp. 8936-8946. (doi: 10.1523/JNEUROSCI.0248-16.2016) (PMID:27559174) (PMCID:PMC4995304)
Havekes, R. et al. (2016) Sleep deprivation causes memory deficits by negatively impacting neuronal connectivity in hippocampal area CA1. eLife, 5, e13424. (doi: 10.7554/eLife.13424) (PMID:27549340) (PMCID:PMC4996653)
Roscoe, R. B., Elliott, C. , Zarros, A. and Baillie, G. S. (2016) Non-genetic therapeutic approaches to Canavan disease. Journal of the Neurological Sciences, 366, pp. 116-124. (doi: 10.1016/j.jns.2016.05.012) (PMID:27288788)
Bachmann, V. A. et al. (2016) GPR61 anchoring of PKA consolidates GPCR and cAMP signaling. Proceedings of the National Academy of Sciences of the United States of America, 113(28), pp. 7786-7791. (doi: 10.1073/pnas.1608061113) (PMID:27357676)
Baillie, G. S. (2016) Editorial. Cellular Signalling, 28(7), pp. 699-700. (doi: 10.1016/j.cellsig.2016.02.001) (PMID:26850139)
Wills, L., Ehsan, M., Whiteley, E. L. and Baillie, G. S. (2016) Location, location, location: PDE4D5 function is directed by its unique N-terminal region. Cellular Signalling, 28(7), pp. 701-705. (doi: 10.1016/j.cellsig.2016.01.008) (PMID:26808969)
Dachtler, J., Elliott, C. , Rodgers, R. J., Baillie, G. S. and Clapcote, S. J. (2016) Missense mutation in DISC1 C-terminal coiled-coil has GSK3β signaling and sex-dependent behavioral effects in mice. Scientific Reports, 6, 18748. (doi: 10.1038/srep18748) (PMID:26728762) (PMCID:PMC4700527)
Baillie, G. S. , Christian, F. and Zarros, A. (2016) Editorial: frontiers in the pharmacological manipulation of intracellular cAMP levels. Frontiers in Pharmacology, 7, 4. (doi: 10.3389/fphar.2016.00004) (PMID:26858646) (PMCID:PMC4731503)
Baeza-Raja, B. et al. (2016) p75 neurotrophin receptor regulates energy balance in obesity. Cell Reports, 14(2), pp. 255-268. (doi: 10.1016/j.celrep.2015.12.028) (PMID:26748707) (PMCID:PMC4831919)
Tankou, S. et al. (2016) SUMOylation of DISC1: a potential role in neural progenitor proliferation in the developing cortex. Molecular Neuropsychiatry, 2(1), pp. 20-27. (doi: 10.1159/000444257) (PMID:27525255) (PMCID:PMC4979612)
Baillie, G. S. (2015) George Baillie on peptide array, a technique that transformed research on phosphodiesterases. Future Science OA, 1(3), FSO27. (doi: 10.4155/fso.15.25) (PMID:28031900) (PMCID:PMC5137849)
MacLeod, R., Hillert, E.-K., Cameron, R. T. and Baillie, G. S. (2015) The role and therapeutic targeting of α-, β- and γ-secretase in Alzheimer's disease. Future Science OA, 1(3), FSO11. (doi: 10.4155/fso.15.9) (PMID:28031886) (PMCID:PMC5137966)
Sin, Y. Y. and Baillie, G. (2015) Heat Shock Protein 20 (HSP20) is a novel substrate for Protein Kinase D1 (PKD1). Cell Biochemistry and Function, 33(7), pp. 421-426. (doi: 10.1002/cbf.3147) (PMID:26443497) (PMCID:PMC4973849)
Zoccarato, A. et al. (2015) Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2. Circulation Research, 117, pp. 707-719. (doi: 10.1161/CIRCRESAHA.114.305892) (PMID:26243800)
Mckinney, C.A., Kennedy, S. , Baillie, G.S. , Milligan, G. and Nicklin, S.A. (2015) Angiotensin-(1-7) and angiotensin-(1-9) inhibit vascular smooth muscle cell growth and migration in vitro and vascular remodelling in vivo. Atherosclerosis, 241(1), e44. (doi: 10.1016/j.atherosclerosis.2015.04.158)
Parnell, E., Koschinski, A., Zaccolo, M., Cameron, R. T., Baillie, G. S. , Baillie, G. L., Porter, A., McElroy, S. P. and Yarwood, S. J. (2015) Phosphorylation of ezrin on Thr567 is required for the synergistic activation of cell spreading by EPAC1 and protein kinase A in HEK293T cells. Biochimica et Biophysica Acta: Molecular Cell Research, 1853(7), pp. 1749-1758. (doi: 10.1016/j.bbamcr.2015.04.009) (PMID:25913012)
Zarros, A., Cameron, R.T., Bimpis, A. and Baillie, G.S. (2015) Exposure of mHIPPOE-14 cells to oligomycin as a tool for in vitro approaches to brain ischaemia-related pro- and epiphenomena: time-dependent cellular response profiling. Atherosclerosis, 241(1), e221. (doi: 10.1016/j.atherosclerosis.2015.04.1038)
Wang, L., Burmeister, B. T., Johnson, K. R., Baillie, G. S. , Karginov, A. V., Skidgel, R. A., O'Bryan, J. P. and Carnegie, G. K. (2015) UCR1C is a novel activator of phosphodiesterase 4 (PDE4) long isoforms and attenuates cardiomyocyte hypertrophy. Cellular Signalling, 27(5), pp. 908-922. (doi: 10.1016/j.cellsig.2015.02.003) (PMID:25683917)
Bolger, G. B., Dunlop, A. J., Meng, D., Day, J. P., Klussmann, E., Baillie, G. S. , Adams, D. R. and Houslay, M. D. (2015) Dimerization of cAMP phosphodiesterase-4 (PDE4) in living cells requires interfaces located in both the UCR1 and catalytic unit domains. Cellular Signalling, 27(4), pp. 756-769. (doi: 10.1016/j.cellsig.2014.12.009) (PMID:25546709) (PMCID:PMC4371794)
Sin, Y. Y., Martin, T. P. , Wills, L., Currie, S. and Baillie, G. S. (2015) Small heat shock protein 20 (Hsp20) facilitates nuclear import of protein kinase D 1 (PKD1) during cardiac hypertrophy. Cell Communication and Signaling, 13, 16. (doi: 10.1186/s12964-015-0094-x) (PMID:25889640) (PMCID:PMC4356135)
Zarros, A. , Johnson, S. A., Mackenzie-Gray Scott, C. A. and Baillie, G. S. (2015) Cytodynamics and endpoint selection for a reliable in vitro assessment of nanoneurotoxicity. Nanomedicine: Nanotechnology, Biology and Medicine, 11(2), pp. 407-408. (doi: 10.1016/j.nano.2014.08.014) (PMID:25461294)
Bottcher, R. et al. (2015) Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression. British Journal of Cancer, 113, pp. 1502-1511. (doi: 10.1038/bjc.2015.335) (PMID:26575822) (PMCID:PMC4815894)
Byrne, A. M., Elliott, C. , Hoffmann, R. and Baillie, G. S. (2015) The activity of cAMP-Phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus. FEBS Letters, 589(6), pp. 750-755. (doi: 10.1016/j.febslet.2015.02.004) (PMID:25680530) (PMCID:PMC4346272)
Kalafatakis, K., Gkanti, V., Mackenzie-Gray Scott, C. A., Zarros, A. , Baillie, G. S. and Tsakiris, S. (2015) Acetylcholinesterase activity as a neurotoxicity marker within the context of experimentally-simulated hyperprolinaemia: an in vitro approach. Journal of Natural Science, Biology and Medicine, 6(3), pp. 98-101. (doi: 10.4103/0976-9668.166099)
McGirr, A. et al. (2015) Specific inhibition of phosphodiesterase-4B results in anxiolysis and facilitates memory acquisition. Neuropsychopharmacology, 41(4), pp. 1080-1092. (doi: 10.1038/npp.2015.240)
Schoenherr, C., Serrels, B., Proby, C., Cunningham, D. L., Findlay, J. E., Baillie, G. S. , Heath, J. K. and Frame, M. (2014) Eps8 controls Src- and FAK-dependent phenotypes in squamous carcinoma cells. Journal of Cell Science, 127(24), pp. 5303-5316. (doi: 10.1242/jcs.157560)
Campbell, A. S., Johnstone, S. R., Baillie, G. S. and Smith, G. (2014) β-Adrenergic modulation of myocardial conduction velocity: Connexins vs. sodium current. Journal of Molecular and Cellular Cardiology, 77, pp. 147-154. (doi: 10.1016/j.yjmcc.2014.09.030)
Christian, F. , Krause, E., Houslay, M. D. and Baillie, G. (2014) PKA phosphorylation of p62/SQSTM1 regulates PB1 domain interaction partner binding. Biochimica et Biophysica Acta: Molecular Cell Research, 1843(11), pp. 2765-2774. (doi: 10.1016/j.bbamcr.2014.07.021) (PMID:25110345)
Kaname, T. et al. (2014) Heterozygous mutations in cyclic AMP phosphodiesterase-4D (PDE4D) and protein kinase A (PKA) provide new insights into the molecular pathology of acrodysostosis. Cellular Signalling, 26(11), pp. 2446-2459. (doi: 10.1016/j.cellsig.2014.07.025)
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Zarros, A. , Bimpis, A., Papalois, A. and Baillie, G. S. (2014) Perihaematomal cytokine expression is a crucial component of intracerebral haemorrhage pathophysiology. Neurological Sciences, 35(9), pp. 1471-1473. (doi: 10.1007/s10072-014-1785-6) (PMID:24729011)
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Huston, E., Houslay, T., Baillie, G. and Houslay, M. (2006) cAMP phosphodiesterase-4A1 (PDE4A1) has provided the paradigm for the intracellular targeting of phosphodiesterases, a process that underpins compartmentalized cAMP signalling. Biochemical Society Transactions, 34, pp. 504-509.
Li, X., Huston, E., Lynch, M., Houslay, M. and Baillie, G. (2006) Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293 beta 2 cells and cardiac myocytes. Biochemical Journal, 394, pp. 427-435. (doi: 10.1042/BJ20051560)
McSorley, T., Stefan, E., Henn, V., Wiesner, B., Baillie, G. , Houslay, M., Rosenthal, W. and Klussmann, E. (2006) Spatial organisation of AKAP18 and PDE4 isoforms in renal collecting duct principal cells. European Journal of Cell Biology, 85, pp. 673-678. (doi: 10.1016/j.ejcb.2006.01.005)
Terrin, A. et al. (2006) PGE(1) stimulation of HEK293 cells generates multiple contiguous domains with different [cAMP]: role of compartmentalized phosphodiesterases. Journal of Cell Biology, 175, pp. 441-451. (doi: 10.1083/jcb.200605050)
Baillie, G. S. , Scott, J. D. and Houslay, M. D. (2005) Compartmentalisation of phosphodiesterases and protein kinase A: opposites attract. FEBS Letters, 579(15), pp. 3264-3270. (doi: 10.1016/j.febslet.2005.03.089)
Baillie, G. and Houslay, M. (2005) Arrestin times for compartmentalised cAMP signalling and phosphodiesterase-4 enzymes. Current Opinion in Cell Biology, 17, pp. 129-134. (doi: 10.1016/j.ceb.2005.01.003)
Henn, V., Stefan, E., Baillie, G. , Houslay, M., Rosenthal, W. and Klussmann, E. (2005) Compartmentalized cAMP signalling regulates vasopressin-mediated water reabsorption by controlling aquaporin-2. Biochemical Society Transactions, 33, pp. 1316-1318.
Hill, E.V., Houslay, M.D. and Baillie, G.S. (2005) Investigation of extracellular signal-regulated kinase 2 mitogen-activated protein kinase phosphorylation and regulation of activity of PDE4 cyclic adenosine monophosphate-specific phosphodiesterases. Methods in Molecular Biology, 307, pp. 225-238. (doi: 10.1385/1-59259-839-0:225)
Houslay, M. and Baillie, G. (2005) beta-Arrestin-recruited phosphodiesterase-4 desensitizes the AKAP79/PKA-mediated switching of beta(2)-adrenoceptor signalling to activation of ERK. Biochemical Society Transactions, 33, pp. 1333-1336.
Lynch, M., Baillie, G. , Mohamed, A., Li, X., Maisonneuve, C., Klussmann, E., van Heeke, G. and Houslay, M. (2005) RNA silencing identifies PDE4D5 as the functionally relevant cAMP phosphodiesterase interacting with beta arrestin to control the protein kinase A/AKAP79-mediated switching of the beta(2)-adrenergic receptor to activation of ERK in HEK293B2 cells. Journal of Biological Chemistry, 280, pp. 33178-33189. (doi: 10.1074/jbc.M414316200)
Millar, J. et al. (2005) DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling. Science, 310, pp. 1187-1191. (doi: 10.1126/science.1112915)
Abrahamsen, H., Baillie, G. , Ngai, J., Vang, T., Nika, K., Ruppelt, A., Mustelin, T., Zaccolo, M., Houslay, M. and Tasken, K. (2004) TCR- and CD28-mediated recruitment of phosphodiesterase 4 to lipid rafts potentiates TCR signaling. Journal of Immunology, 173, pp. 4847-4858.
Barber, R., Baillie, G.S. , Bergmann, R., Shepherd, M.C., Sepper, R., Houslay, M.D. and Van Heeke, G. (2004) Differential expression of PDE4 cAMP phosphodiesterase isoforms in inflammatory cells of smokers with COPD, smokers without COPD, and nonsmokers. American Journal of Physiology: Lung Cellular and Molecular Physiology, 287, L332-L343. (doi: 10.1152/ajplung.00384.2003)
Johnston, L. et al. (2004) Expression, intracellular distribution and basis for lack of catalytic activity of the PDE4A7 isoform encoded by the human PDE4A cAMP-specific phosphodiesterase gene. Biochemical Journal, 380, pp. 371-384.
Shepherd, M., Baillie, G. , Stirling, D. and Houslay, M. (2004) Remodelling of the PDE4 cAMP phosphodiesterase isoform profile upon monocyte-macrophage differentiation of human U937 cells. British Journal of Pharmacology, 142, pp. 339-351. (doi: 10.1038/sj.bjp.0705770)
Baillie, G. , Sood, A., McPhee, I., Gall, I., Perry, S., Lefkowitz, R. and Houslay, M. (2003) β-Arrestin-mediated PDE4 cAMP phosphodiesterase recruitment regulates β-adrenoceptor switching from Gs to Gi. Proceedings of the National Academy of Sciences of the United States of America, 100(3), pp. 940-945. (doi: 10.1073/pnas.262787199)
Bolger, G., McCahill, A., Huston, E., Cheung, Y., McSorley, T., Baillie, G. and Houslay, M. (2003) The unique amino-terminal region of the PDE4D5 cAMP phosphodiesterase isoform confers preferential interaction with beta-arrestins. Journal of Biological Chemistry, 278, pp. 49230-49238. (doi: 10.1074/jbc.M303772200)
Bolger, G., Peden, A., Steele, M., MacKenzie, C., McEwan, D., Wallace, D., Huston, E., Baillie, G. and Houslay, M. (2003) Attenuation of the activity of the cAMP-specific phosphodiesterase PDE4A5 by interaction with the immunophilin XAP2. Journal of Biological Chemistry, 278, pp. 33351-33363. (doi: 10.1074/jbc.M303269200)
Houslay, M. and Baillie, G. (2003) The role of ERK2 docking and phosphorylation of PDE4 cAMP phosphodiesterase isoforms in mediating cross-talk between the cAMP and ERK signalling pathways. Biochemical Society Transactions, 31, pp. 1186-1190.
Shepherd, M., McSorley, T., Olsen, A., Johnston, L., Thomson, N., Baillie, G. , Houslay, M. and Bolger, G. (2003) Molecular cloning and subcellular distribution of the novel PDE4B4 cAMP-specific phosphodiesterase isoform. Biochemical Journal, 370, pp. 429-438.
Terry, R., Cheung, Y., Praestegaard, M., Baillie, G. , Huston, E., Gall, I., Adams, D. and Houslay, M. (2003) Occupancy of the catalytic site of the PDE4A4 cyclic AMP phosphodiesterase by rolipram triggers the dynamic redistribution of this specific isoform in living cells through a cyclic AMP independent process. Cellular Signalling, 15, pp. 955-971. (doi: 10.1016/S0898-6568(03)00092-5)
Adam, B., Baillie, G. and Douglas, L. (2002) Mixed species biofilms of Candida albicans and Staphylococcus epidermidis. Journal of Medical Microbiology, 51, pp. 344-349.
Baillie, G. (2002) A synthetic low density lipoprotein particle capable of supporting U937 proliferation in vitro. Journal of Lipid Research, 43(1), pp. 69-73.
Baillie, G. et al. (2002) TAPAS-1, a novel microdomaln within the unique N-terminal region of the PDE4A1 cAMP-specific phosphodiesterase that allows rapid, Ca2+-triggered membrane association with selectivity for interaction with phosphatidic acid. Journal of Biological Chemistry, 277, pp. 28298-28309. (doi: 10.1074/jbc.M108353200)
MacKenzie, S., Baillie, G. , McPhee, I., MacKenzie, C., Seamons, R., McSorley, T., Millen, J., Beard, M., van Heeke, G. and Houslay, M. (2002) Long PDE4 cAMP specific phosphodiesterases are activated by protein kinase A-mediated phosphorylation of a single serine residue in Upstream Conserved Region 1 (UCR1). British Journal of Pharmacology, 136, pp. 421-433.
Perry, S. et al. (2002) Targeting of cyclic AMP degradation to beta(2)-adrenergic receptors by beta-arrestins. Science, 298, pp. 834-836.
Baillie, G. , MacKenzie, S. and Houslay, M. (2001) Phorbol 12-myristate 13-acetate triggers the protein kinase A-mediated phosphorylation and activation of the PDE4D5 cAMP phosphodiesterase in human aortic smooth muscle cells through a route involving extracellular signal regulated kinase (ERK). Molecular Pharmacology, 60, pp. 1100-1111.
Baillie, G. (2001) Physicochemical properties of microemulsion analogues of low density lipoprotein containing amphiphatic apoprotein B receptor sequences. International Journal of Pharmaceutics, 228(39479), pp. 109-117. (doi: 10.1016/S0378-5173(01)00818-3)
Book Sections
Williams, J. J.L., Baillie, G. S. and Palmer, T. M. (2020) Investigation of Novel Cavin-1/Suppressor of Cytokine Signaling 3 (SOCS3) Interactions by Coimmunoprecipitation, Peptide Pull-Down, and Peptide Array Overlay Approaches. In: Blouin, C. M. (ed.) Caveolae. Series: Methods in Molecular Biology (2169). Springer: New york, NY, pp. 105-118. ISBN 9781071607312 (doi: 10.1007/978-1-0716-0732-9_10)
Tibbo, A. J., Busiau, T. and Baillie, G. S. (2019) Methods to investigate arrestins in complex with phosphodiesterases. In: Scott, M. G.H. and Laporte, S. A. (eds.) Beta-Arrestins. Series: Methods in molecular biology (1957). Springer: New York, pp. 121-137. (doi: 10.1007/978-1-4939-9158-7_8)
Cameron, R.T. and Baillie, G.S. (2014) Arrestin regulation of small GTPases. In: Gurevich, V.V. (ed.) Arrestins: Pharmacology and Therapeutic Potential. Series: Handbook of Experimental Pharmacology (219). Springer, pp. 375-385. ISBN 9783642411991 (doi: 10.1007/978-3-642-41199-1_19)
Willis, M.J. and Baillie, G.S. (2014) Arrestin-dependent localization of phosphodiesterases. In: Gurevich, V.V. (ed.) Arrestins: Pharmacology and Therapeutic Potential. Series: Handbook of Experimental Pharmacology (219). Springer, pp. 293-307. ISBN 9783642411991 (doi: 10.1007/978-3-642-41199-1_15)
Cameron, R.T. and Baillie, G.S. (2012) cAMP-specific phosphodiesterase: modulation, inhibition and activation. In: Botana, L.M. and Loza, M. (eds.) Therapeutic Targets: Modulation, Inhibition, and Activation. John Wiley & Sons Ltd: Hoboken, N.J.. ISBN 9780470587195
Edited Books
Baillie, G. S. , Christian, F. and Zarros, A. (Eds.) (2016) Frontiers in the Pharmacological Manipulation of Intracellular cAMP Levels. Series: Frontiers in pharmacology. Frontiers Media: Lausanne. ISBN 9782889198153
Conference or Workshop Item
Baillie, G. et al. (2022) Evaluating the Utility of Bi-functional Degrader Molecules for Selective Inhibition of PDE4 In Acrodysostosis Type2. 60th Annual ESPE (ESPE 2022), Rome, Italy, 15-17 Sept 2022.
Armfield, K., Baillie, G. and Wilson, J.B. (2018) Development of Therapeutic Approaches to Targeting Epstein-Barr virus Related Malignancies. International Conference on EBV and KSHV 2018, Wisconsin, USA, 28 Jul - 1 Aug 2018.
Hussain, M., Baillie, G. , Gatherer, D. and Wilson, J.B. (2012) Investigating Molecular Interactions Between Epstein-Barr Virus Nuclear Antigen-1 and Partner Proteins. International Congress on Oncogenic Herpesviruses and Associated Diseases, Philadelphia, PA, USA, 01-05 Aug 2012.
Hussain, M., Baillie, G. , Gatherer, D. and Wilson, J.B. (2012) Investigating Molecular Interactions Between Epstein-Barr Virus Nuclear Antigen-1 and Partner Proteins. Tenovus 30th Aniversary Symposium: Molecular Mechanisms of Disease, Glasgow, UK, 6-7 Jun 2012.
Conference Proceedings
Campbell, A. S., Burton, F. L., Baillie, G. and Smith, G. L. (2014) Action potential conduction velocity is increased by raised intracellular camp in the intact rat heart via a CaMKII mediated pathway. In: 58th Annual Meeting of the Biophysical-Society, San Francisco CA, USA, 15-19 Feb 2014, 119a.
Youn, S., Budatha, M., Baillie, G. and Schwartz, M. (2014) ECM-specific endothelial inflammatory signaling: regulation by integrin alpha5 interaction with PDE4D. In: Vascular Matrix Biology and Bioengineering Workshop IV and Biology of Signaling in the Cardiovascular System Workshop III, Hyannis, MA, USA, 20-24 Oct 2013, p. 313. (doi: 10.1007/s10456-013-9412-3)
Havekes, R., Choi, J.H., Bruinenberg, V., Baillie, G. , Park, A., Day, J., Aton, S., Meerlo, P., Houslay, M. and Abel, T. (2012) Blocking the phosphodiesterase isoform PDE4A5 in the hippocampus ameliorates plasticity and memory deficits induced by brief sleep deprivation. In: Annual Meeting of the Associated-Professional-Sleep-Societies (APSS), Boston, MA, USA, 9-13 June 2012, A94-A95.
Havekes, R., Choi, J.H., Bruinenberg, V., Baillie, G.S. , Park, A., Day, J., Anton, S., Meerlo, P., Houslay, M.D. and Abel, T. (2012) Cognitive impairments induced by brief sleep deprivation can be prevented by targeting a single phosphodiesterase isoform selectively in the hippocampus [abstract]. In: 42nd Annual Meeting of the Society-for-Neuroscience, New Orleans, Louisiana, USA, Oct 13 - Oct 17 2012,
Havekes, R., Choi, J.H., Bruinenberg, V., Baillie, G.S. , Park, A., Day, J., Anton, S., Meerlo, P., Houslay, M.D. and Abel, T. (2012) Gravin is a key scaffolding protein that orchestrates PKA and beta 2-adrenergic receptor signaling important for long-lasting forms of synaptic plasticity and long-term memory [abstract]. In: 42nd Annual Meeting of the Society for Neuroscience, New Orleans, Louisiana, USA, Oct 13 - Oct 17 2012,
Patents
Iti Scotland Limited (2013) New Substituted Peptide Compounds are Beta Transducin Repeat-Containing Protein Modulators, Useful for Treating e.g. Breast Cancer, Arthritis, Osteoarthritis, Rheumatoid Arthritis, Crohn's Disease and Irritable Bowel Syndrome. .
The University Court of The University of Glasgow (2012) Increasing HSP20 Activation in Biological Systems Involves Antagonists Capable of Inhibiting PDE4 Binding. .
Grants
Grants and Awards listed are those received whilst working with the University of Glasgow.
- Optimisation of c-RAF inhibitor peptide for KRAS-driven pancreatic cancer
Medical Research Council
2023 - 2024
- Lead optimisation of an allosteric c-RAF inhibitor peptide for the treatment of KRAS-driven pancreatic cancer
Engineering and Physical Sciences Research Council
2023 - 2024
- Function follows form 2.0: from cellular mechanics and nanodomains to mechanisms of cardiomyopathies and therapeutic strategies.
British Heart Foundation
2023 - 2027
- MRC CiC:5th Generation CAR-T Cell Therapy for Prostate Cancer
Medical Research Council
2022 - 2023
- Inhibiting c-Raf activity and treating pancreatic cancer
Medical Research Council
2022 - 2022
- Inhibiting c-Raf activity and treating pancreatic cancer - Follow on
Medical Research Council
2022 - 2023
- RSE Saltire International Collaboration award
The Royal Society of Edinburgh
2022 - 2024
- Biotheryx Collaboration
Medical Research Council
2021 - 2022
- Peptide Therapeutics
Scottish Enterprise
2021 - 2022
- Novel PDE4B-specific inhibitors for cancer.
Bio Thery X
2021 - 2023
- Targeting PDE3/4 to allow regulation of cardiac calcium homeostasis in disease
British Heart Foundation
2021 - 2023
- CiC New Treatments for Heart Failure with Preserved Ejection Fraction (HFpEF)
Medical Research Council
2017 - 2018
- CiC Enhancing Mas:ETB receptor interaction: A novel therapeutic modality for pulmonary hypertension.
Medical Research Council
2016 - 2018
- Regulation of Anti-inflammatory Gene Expression in Vascular Endothelial Cells by EPAC1
British Heart Foundation
2015 - 2018
- Validation of the PDE4D7 interactome
Prostate Cancer UK
2015 - 2016
- Pathway-driven identification of therapeutic targets for combating Alzheimer's disease.
Medical Research Council
2015 - 2018
- Accumulation of novel information cncerning the cell signalling pathways underpinning colorectal cancer, as well as possible new treatments
The Great Britain Sasakawa Foundation
2015 - 2018
- P2D award - GRACE II - PPL/SANNOX discussion with external advisors: targets and therapeutic indications
Medical Research Council
2015 - 2017
- CiC: Small molecules targeting the PDE4A4-p75NTR interaction, a novel target for fibrotic diseases
Medical Research Council
2014 - 2015
- Extracellular signal-regulated kinase 5 (ERK5) and regulation of neuroendocrine differentiation in prostate cancer
Chief Scientist Office
2012 - 2014
- cAMP phosphodiesterase-4: signalling complexes, regulation and potential therapeutic targets.
Medical Research Council
2012 - 2015
- Small molecules that induce the cardio-protective effects of HSP20
Heart Research UK
2012 - 2014
- Disrupting arresting binding partners to influence cell shape and mobility
The Royal Society
2011 - 2013
- Phosphodiesterase-4 isoforms - intracellular targeting, regulation and potential therapeutic targets
Medical Research Council
2007 - 2012
- Transatlantic networks of excellence in cardiovascular disease
Fondation Leducq
2006 - 2012
Supervision
- Donnelly, Michael
PDE4 PROTACS as novel therapeutics - McFarlane, Richard
Translational Medical Science for Therapy Development in Sm - Parsons, Emma
Molecular characterization of RNAseq identified changes in TCR signaling in prostate cancer disease
Teaching
1st year teaching : Biology 1B (DNA, RNA and protein)
2nd Year Teaching: Medicine Year 2 Lab practical on Acid/Base Balance
3rd Year Teaching: Teaching on the Neuroscience 3A course, Biochemistry 3A course, Molecular and Cell Biology 3B, Biochemistry 3B tutorials
4th Year Teaching : Course coordinator for the "Cell Signalling and disease" option, Deputy coordinator for the "Core Skills in Pharmacology" Option, teaching on the "Biotechnology" option
Additional information
Editorial Board
- 2007 - present: Journal of Cellular Signalling - Co-editor
Invited International Presentations
- 2011: Charles Darwin House, London, UK - EPS sponsored meeting "Peptide arrays as tools for studying protein interactions"
- 2010: Waterville Valley, New Hampshire, USA - Gordon Research Conference, Cyclic Nucleotide Phosphodiesterases
- 2010: Breckenridge, Colorado, USA - Keystone Symposia on Molecular and Cellular Biology, G Protein Coupled Receptors
- 2010: Paris, France - EU Gene Heart Seminar Series
- 2010: Oslo, Norway - 3rd international meeting on Anchored cAMP Signalling
- 2008: Oslo, Norway - FEBS/ESF Workshop, 16th Protein Kinase Meeting
- 2008: Barga, Italy - Gordon Research Conference on Cyclic Nucleotide Phosphodiesterases
- 2006: Cambridge, England, UK - Invited speaker at Biochemical Society Focused Meeting on Compartmentalisation of cAMP Signaling, 2006, King's College, Cambridge
- 2006: University of Durham, England, UK - Contemporary Issues in Cyclic Nucleotide Signalling
- 2006: University of New England, USA - Gordon Research conference on Cyclic Nucleotide Phosphodiesterases
- 2005: Berlin-Buch - 1st International Meeting on Anchored cAMP Signalling Pathways
- 2004: Mainz, Germany - "New trends in G protein-mediated signalling", 45th Annual Meeting, German Society for Experimental and Clinical Pharmacology
- 2003: University of Essex, Essex, UK - Biochemical Society Meeting 679, Stress
