Healthcare Data

Our researchers lead national and international efforts to improve patient outcomes using healthcare data across cardiovascular, cerebrovascular, kidney disease, diabetes, geriatric care and COVID-19. 

Staff

Publications

2024

Ramses, R., Kennedy, S., Good, R., Oldroyd, K. G., Mcginty, S. (2024) Performance of drug-coated balloons in coronary and below-the-knee arteries: anatomical, physiological and pathological considerations. Vascular Pharmacology, 155, (doi: 10.1016/j.vph.2024.107366)

Lang, N., Rankin, S., Elyan, B., Jones, R., Venugopal, B., Mark, P. B., Lees, J., Petrie, M., Lang, N. (2024) Cardiovascular eligibility criteria and adverse event reporting in combined immune checkpoint and VEGF inhibitors trials. JACC: CardioOncology, 6, pp. 267-279. (doi: 10.1016/j.jaccao.2023.12.010)

Carberry, J., Petrie, M. C., Lee, M. M.Y., Brooksbank, K., Campbell, R. T., Good, R., Jhund, P. S., Kellman, P., Lang, N. N., Mangion, K., Mark, P. B., McConnachie, A., McMurray, J. J.V., Meyer, B., Orchard, V., Shaukat, A., Watkins, S., Welsh, P., Sattar, N., Berry, C., Docherty, K. F. (2024) Empagliflozin to prevent progressive adverse remodelling after myocardial infarction (EMPRESS-MI): rationale and design. ESC Heart Failure,

Butt, J., Jhund, P. S., Docherty, K. F., Claggett, B. L., Vaduganathan, M., Bachus, E., Hernandez, A. F., Lam, C. S.P., Inzucchi, S. E., Martinez, F. A., de Boer, R. A., Kosiborod, M. N., Desai, A. S., Køber, L., Ponikowski, P., Sabatine, M. S., Solomon, S. D., McMurray, J. J.V. (2024) Dapagliflozin and timing of prior heart failure hospitalization a patient-level meta-analysis of DAPA-HF and DELIVER. JACC: Heart Failure, (doi: 10.1016/j.jchf.2024.01.018)

Peikert, A., Bart, B. A., Vaduganathan, M., Claggett, B. L., Kulac, I. J., Kosiborod, M. N., Desai, A. S., Jhund, P. S., Lam, C. S.P., Inzucchi, S. E., Martinez, F. A., de Boer, R. A., Hernandez, A. F., Shah, S. J., Petersson, M., Langkilde, A. M., McMurray, J. J. V., Solomon, S. D., Vardeny, O. (2024) Contemporary use and implications of beta-blockers in patients with HFmrEF or HFpEF: the DELIVER Trial. JACC: Heart Failure, 12, pp. 631-644. (doi: 10.1016/j.jchf.2023.09.007)

Alsanosi, S. M., Padmanabhan, S. (2024) Potential applications of artificial intelligence (AI) in managing polypharmacy in Saudi Arabia: a narrative review. Healthcare, 12, (doi: 10.3390/healthcare12070788)

Docherty, K. F., McMurray, J. J.V., Kalra, P., Cleland, J. G.F., Lang, N. N., Petrie, M. C., Robertson, M., Ford, I. (2024) Intravenous iron and SGLT2 inhibitors in iron-deficient patients with heart failure and reduced ejection fraction. ESC Heart Failure, (doi: 10.1002/ehf2.14742)

Tran, T. Q. B., Lip, S., du Toit, C., Kalaria, T. K., Bhaskar, R. K., O'Neil, A. Q., Graff, B., Hoffmann, M., Szyndler, A., Polonis, K., Wolf, J., Reddy, S., Narkiewicz, K., Dasgupta, I., Dominiczak, A. F., Visweswaran, S., McCallum, L., Padmanabhan, S. (2024) Assessing machine learning for diagnostic classification of hypertension types identified by ambulatory blood pressure monitoring. CJC Open, (doi: 10.1016/j.cjco.2024.03.005)

Shemilt, R., Sullivan, M.K., Hanlon, P., Jani, B., De La Mata, N., Rosales, B., Elyan, B.M.P., Hedley, J.A., Cutting, R.B., Wyld, M., McAllister, D.A., Webster, A.C., Mark, P.B., Lees, J.S. (2024) Sex differences in cancer outcomes across the range of eGFR. Nephrology Dialysis Transplantation, (doi: 10.1093/ndt/gfae059)

Kobayashi, M., Ferreira, J. P., Kevin, D., Bresso, E., Huttin, O., Bozec, E., Brunner La Rocca, H.-P., Delles, C., Clark, A. L., Edelmann, F., González, A., Heymans, S., Pellicori, P., Petutschnigg, J., Verdonschot, J. A.J., Rossignol, P., Cleland, J. G.F., Zannad, F., Girerd, N. (2024) Proteomic profiles of left atrial volume and its influence on response to spironolactone: findings from the HOMAGE trial and STANISLAS cohort. European Journal of Heart Failure,

Cleland, J. G.F., Kalra, P. A., Pellicori, P., Graham, F. J., Foley, P. W.X., Squire, I. B., Cowburn, P. J., Seed, A., Clark, A. L., Szwejkowski, B., Banerjee, P., Cooke, J., Francis, M., Clifford, P., Wong, A., Petrie, C., McMurray, J. J.V., Thomson, E. A., Wetherall, K., Robertson, M., Ford, I., Kalra, P. R. (2024) Intravenous iron for heart failure, iron deficiency definitions, and clinical response: the IRONMAN trial. European Heart Journal, (doi: 10.1093/eurheartj/ehae086)

Ciminata, G., Burton, J.K., Quinn, T.J., Geue, C. (2024) Understanding Pathways into Care-homes using Data (UnPiCD study): a two-part model to estimate inpatient and care-home costs using national linked health and social care data. BMC Health Services Research, 24, (doi: 10.1186/s12913-024-10675-z)

Grobbee, D. E., Filippatos, G., Desai, N. R., Coats, A. J.S., Pinto, F., Rosano, G. M.C., Cleland, J., Kammerer, J., Ramirez de Arellano, A. (2024) Epidemiology and risk factors for hyperkalaemia in heart failure. ESC Heart Failure, (doi: 10.1002/ehf2.14661)

Butt, J. H., Jering, K., de Boer, R. A., Claggett, B. L., Desai, A. S., Hernandez, A. F., Inzucchi, S. E., Jhund, P. S., Køber, L., Kosiborod, M. N., Lam, C. S.P., Martinez, F. A., Ponikowski, P., Sabatine, M. S., Shah, S. J., Vaduganathan, M., Langkilde, A. M., Bengtsson, O., Petersson, M., Sjöstrand, M., McMurray, J. J.V. (2024) Heart failure, investigator-reported sleep apnea and dapagliflozin: A patient-level pooled meta-analysis of DAPA-HF and DELIVER. Journal of Cardiac Failure, 30, pp. 436-448. (doi: 10.1016/j.cardfail.2023.08.027)

McCallum, L., Lip, S., Rostron, M., Hanna, R., Salimin, N. B. P. M., Nichol, S., Padmanabhan, S. (2024) OPTIMA-BP: empOwering PaTients in MAnaging Blood Pressure – protocol for a randomised parallel group study comparing use of Kvatchii web-based patient education portal as an addition to home blood pressure monitoring. Open Heart, 11, (doi: 10.1136/openhrt-2023-002535)

Morrow, A. J. et al. (2024) Socioeconomic deprivation and illness trajectory in the Scottish population after COVID-19 hospitalization. Communications Medicine, 4, (doi: 10.1038/s43856-024-00455-5)

Lean, M. E.J., Leslie, W. S., Barnes, A. C., Brosnahan, N., Thom, G., McCombie, L., Kelly, T., Irvine, K., Peters, C., Zhyzhneuskaya, S., Hollingsworth, K. G., Adamson, A. J., Sniehotta, F. F., Mathers, J. C., McIlvenna, Y., Welsh, P., McConnachie, A., McIntosh, A., Sattar, N., Taylor, R. (2024) 5-year follow-up of the randomised Diabetes Remission Clinical Trial (DiRECT) of continued support for weight loss maintenance in the UK: an extension study. Lancet Diabetes and Endocrinology, (doi: 10.1016/S2213-8587(23)00385-6)

Bhatt, A. S., Vaduganathan, M., Claggett, B. L., Kulac, I. J., Anand, I. S., Desai, A. S., Fang, J. C., Hernandez, A. F., Jhund, P. S., Kosiborod, M. N., Sabatine, M. S., Shah, S. J., Vardeny, O., McMurray, J. J. V., Solomon, S. D., Gaziano, T. A. (2024) Cost effectiveness of dapagliflozin for heart failure across the spectrum of ejection fraction: an economic evaluation based on pooled, individual participant data from the DELIVER and DAPA-HF trials. Journal of the American Heart Association, (doi: 10.1161/JAHA.123.032279)

Pellicori, P., Felker, G. M., Cleland, J. G.F. (2024) Reply to ‘Vasodilators in congestive heart failure: The perfect weapon aiming just off the target?’ European Journal of Heart Failure, 26, pp. 528-528. (doi: 10.1002/ejhf.3159)

Friedman, D. J., Olivas-Martinez, A., Dalgaard, F., Fudim, M., Abraham, W. T., Cleland, J. G.F., Curtis, A. B., Gold, M. R., Kutyifa, V., Linde, C., Tang, A. S., Ali-Ahmed, F., Inoue, L. Y.T., Sanders, G. D., Al-Khatib, S. M. (2024) Relationship between sex, body size, and cardiac resynchronization therapy benefit: a patient level meta-analysis of randomized controlled trials. Heart Rhythm, (doi: 10.1016/j.hrthm.2024.01.058)

Lakhal-Littleton, S., Cleland, J. G. F. (2024) Iron deficiency and supplementation in heart failure. Nature Reviews Cardiology, (doi: 10.1038/s41569-024-00988-1)

Burton, J. K., McMinn, M., Vaughan, J. E., Nightingale, G., Fleuriot, J., Guthrie, B. (2024) Analysis of the impact of COVID-19 on Scotland’s care homes from March 2020 to October 2021: National linked data cohort analysis. Age and Ageing, 53, (doi: 10.1093/ageing/afae015)

Welsh, P., Al Zabiby, A., Byrne, H., Benbow, H. R., Itani, T., Farries, G., Costa-Scharplatz, M., Ferber, P., Martin, L., Brown, R., Fonseca, A. F., Sattar, N. (2024) Elevated lipoprotein(a) increases risk of subsequent major adverse cardiovascular events (MACE) and coronary revascularisation in incident ASCVD patients: a cohort study from the UK biobank. Atherosclerosis, 389, (doi: 10.1016/j.atherosclerosis.2023.117437)

Chybowska, A. D., Gadd, D. A., Cheng, Y., Bernabeu, E., Campbell, A., Walker, R. M., McIntosh, A. M., Wrobel, N., Murphy, L., Welsh, P., Sattar, N., Price, J. F., McCartney, D. L., Evans, K. L., Marioni, R. E. (2024) Epigenetic contributions to clinical risk prediction of cardiovascular disease. Circulation: Genomic and Precision Medicine, 17, (doi: 10.1161/CIRCGEN.123.004265)

Butt, J. H., McDowell, K., Kondo, T., Desai, A. S., Lefkowitz, M. P., Packer, M., Petrie, M. C., Pfeffer, M. A., Rouleau, J. L., Vaduganathan, M., Zile, M. R., Jhund, P. S., Køber, L., Solomon, S., McMurray, J. J.V. (2024) Heart failure with preserved ejection fraction, red cell distribution width, and sacubitril/valsartan. ESC Heart Failure, 11, pp. 65-77. (doi: 10.1002/ehf2.14558)

Bull, C. J. et al. (2024) Impact of weight loss on cancer-related proteins in serum: results from a cluster randomised controlled trial of individuals with type 2 diabetes. EBioMedicine, 100, (doi: 10.1016/j.ebiom.2024.104977)

Jackson, A. M., Goland, S., Farhan, H. A., Yaseen, I. F., Prameswari, H. S., Böhm, M., Jhund, P. S., Maggioni, A. P., van der Meer, P., Sliwa, K., Bauersachs, J., Petrie, M. C. (2024) A novel score to predict left ventricular recovery in peripartum cardiomyopathy derived from the ESC EORP Peripartum Cardiomyopathy Registry. European Heart Journal, (doi: 10.1093/eurheartj/ehad888)

Pellicori, P., Cleland, J. G.F. (2024) Atrial myopathy and heart failure with preserved ejection fraction: When a label does more harm than good? European Journal of Heart Failure, (doi: 10.1002/ejhf.3148)

Ali, M., Tibble, H., Brady, M. C., Quinn, T. J., Sunnerhagen, K. S., Venketasubramanian, N., Shuaib, A., Pandyan, A., Mead, G., on behalf of the VISTA collaboration, (2024) Validation of general pain scores from multidomain assessment tools in stroke. Frontiers in Neurology, 15, (doi: 10.3389/fneur.2024.1328832)

Cuthbert, J. J., Brown, O. I., Pellicori, P., Dobbs, K., Bulemfu, J., Kazmi, S., Sokoreli, I., Pauws, S. C., Riistama, J. M., Cleland, J. G.F., Clark, A. L. (2024) Medicines optimization prior to discharge in patients admitted to hospital with heart failure. ESC Heart Failure, (doi: 10.1002/ehf2.14638)

Irvine, L., Burton, J., Ali, M., Booth, J., Desborough, J., Logan, P., Moniz-Cook, E., Surr, C., Wright, D., Goodman, C. (2024) Data resource profile: the Virtual International Care Home Trials Archive (VICHTA) International Journal of Population Data Science, 8, (doi: 10.23889/ijpds.v8i6.2161)

Pellicori, P., Hunter, D., Khin, H. H. E., Cleland, J. G.F. (2024) How to diagnose and treat venous congestion in heart failure. European Heart Journal, (doi: 10.1093/eurheartj/ehad883)

Pellicori, P., Cleland, J. G.F. (2024) Atrial myopathy and HFpEF - when a label does more harm than good. European Journal of Heart Failure,

Zeitler, E. P., Dalgaard, F., Abraham, W. T., Cleland, J. G.F., Curtis, A. B., Friedman, D. J., Gold, M. R., Kutyifa, V., Linde, C., Tang, A. S., Olivas-Martinez, A., Inoue, L. Y.T., Sanders, G. D., Al-Khatib, S. M. (2024) Benefit of cardiac resynchronization therapy among older patients: A patient-level meta-analysis. American Heart Journal, 267, pp. 81-90. (doi: 10.1016/j.ahj.2023.11.002)

Cleland, J. G. F. (2024) Defining iron deficiency in patients with heart failure. Nature Reviews Cardiology, 21, pp. 1-2. (doi: 10.1038/s41569-023-00951-6)

Lee, M. M.Y., Kondo, T., Campbell, R. T., Petrie, M. C., Sattar, N., Solomon, S. D., Vaduganathan, M., Jhund, P. S., McMurray, J. J.V. (2024) Effects of Renin-Angiotensin system blockers on outcomes from COVID-19: a systematic review and meta-analysis of randomised controlled trials. European Heart Journal: Cardiovascular Pharmacotherapy, 10, pp. 68-80. (doi: 10.1093/ehjcvp/pvad067)

Sofianopoulou, E. et al. (2024) Estimating dose—response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and revised Mendelian randomization analyses. Lancet Diabetes and Endocrinology, 12, pp. E2-E11. (doi: 10.1016/S2213-8587(23)00287-5)

Monzo, L., Girerd, N., Ferreira, J. P., Lamiral, Z., Anker, S. D., Cleland, J. G. F., Kondo, T., McMurray, J. J. V., Lam, C. S. P., Mehra, M. R., van Veldhuisen, D. J., Greenberg, B., Zannad, F. (2024) High risk of stroke in patients with worsening heart failure, reduced ejection fraction, coronary heart disease and sinus rhythm: risk prediction score analysis from the COMMANDER-HF trial. Journal of Cardiac Failure, (doi: 10.1016/j.cardfail.2023.11.020)

2023

Ostrominski, J. W., Vaduganathan, M., Selvaraj, S., Claggett, B. L., Miao, Z. M., Desai, A. S., Jhund, P. S., Kosiborod, M. N., Lam, C. S.P., Inzucchi, S. E., Martinez, F. A., de Boer, R. A., Hernandez, A. F., Shah, S. J., Petersson, M., Maria Langkilde, A., McMurray, J. J.V., Solomon, S. D. (2023) Dapagliflozin and apparent treatment-resistant hypertension in heart failure with mildly reduced or preserved ejection fraction: The DELIVER trial. Circulation, 148, pp. 1945-1957. (doi: 10.1161/CIRCULATIONAHA.123.065254)

Welsh, P., Kimenai, D. M., Shah, A. S.V., Gadd, D. A., Marioni, R. E., Woodward, M., Sudlow, C. L.M., Campbell, A., Cleland, J. G.F., Pellicori, P., Hayward, C., Mills, N. L., Sattar, N. (2023) Multiple cardiac biomarkers to improve prediction of cardiovascular events: findings from the Generation Scotland Scottish Family Health Study. Clinical Chemistry, 70, pp. 403-413. (doi: 10.1093/clinchem/hvad205)

Vardeny, O., Fang, J. C., Desai, A. S., Jhund, P. S., Claggett, B., Vaduganathan, M., de Boer, R. A., Hernandez, A. F., Lam, C. S. P., Inzucchi, S. E., Martinez, F. A., Kosiborod, M. N., DeMets, D., O’Meara, E., Zieroth, S., Comin-Colet, J., Drozdz, J., Chiang, C.-E., Kitakaze, M., Petersson, M., Lindholm, D., Langkilde, A. M., McMurray, J. J.V., Solomon, S. D. (2023) Author Correction: Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial. Nature Medicine, 29, pp. 3269-3269. (doi: 10.1038/s41591-023-02302-x)

Matsumoto, S., Kondo, T., Yang, M., Campbell, R. T., Docherty, K. F., de Boer, R. A., Desai, A. S., Lam, C. S.P., Packer, M., Pitt, B., Rouleau, J. L., Vaduganathan, M., Zannad, F., Zile, M. R., Solomon, S. D., Jhund, P. S., McMurray, J. J.V. (2023) Calcium channel blocker use and outcomes in patients with heart failure and mildly reduced and preserved ejection fraction. European Journal of Heart Failure, 25, pp. 2202-2214. (doi: 10.1002/ejhf.3044)

Kondo, T., Butt, J. H., Curtain, J. P., Jhund, P. S., Docherty, K. F., Claggett, B. L., Vaduganathan, M., Bachus, E., Hernandez, A. F., Lam, C. S.P., Inzucchi, S. E., Martinez, F. A., de Boer, R. A., Kosiborod, M. N., Desai, A. S., Køber, L., Ponikowski, P., Sabatine, M. S., Solomon, S. D., McMurray, J. J.V. (2023) Efficacy of dapagliflozin according to heart rate: A patient-level pooled analysis of DAPA-HF and DELIVER. Circulation: Heart Failure, 16, (doi: 10.1161/CIRCHEARTFAILURE.123.010898)

Bhatt, A. S., Kosiborod, M. N., Claggett, B. L., Miao, Z. M., Vaduganathan, M., Lam, C. S. P., Hernandez, A. F., Martinez, F. A., Inzucchi, S. E., Shah, S. J., de Boer, R. A., Jhund, P. S., Desai, A. S., Fang, J. C., Han, Y., Comin‐Colet, J., Drożdż, J., Vardeny, O., Merkely, B., Lindholm, D., Peterson, M., Langkilde, A. M., McMurray, J. J. V., Solomon, S. D. (2023) Impact of COVID‐19 in patients with heart failure with mildly reduced or preserved ejection fraction enrolled in the DELIVER trial. European Journal of Heart Failure, 25, pp. 2177-2188. (doi: 10.1002/ejhf.3043)

Zahir Anjum, D., Strange, J. E., Fosbøl, E., Garred, C. H., Malik, M. E., Andersson, C., Jhund, P. S., McMurray, J. J.V., Petrie, M. C., Kober, L., Schou, M. (2023) Initiation of medical therapy for heart failure patients according to kidney function: a Danish nationwide study. Clinical Epidemiology, 15, pp. 855-866. (doi: 10.2147/clep.s412787)

Ali, M., Tibble, H., Brady, M. C., Quinn, T. J., Sunnerhagen, K. S., Venketasubramanian, N., Shuaib, A., Pandyan, A., Mead, G. (2023) Prevalence, trajectory and predictors of post stroke pain: retrospective analysis of pooled clinical trial datasets. Stroke, 54, pp. 3107-3116. (doi: 10.1161/STROKEAHA.123.043355)

Berry, C. et al. (2023) Mental health symptoms and illness trajectory following COVID-19 hospitalization: A cohort study. Heart and Mind, 7, pp. 235-245. (doi: 10.4103/hm.HM-D-23-00037)

Chatur, S., Vaduganathan, M., Claggett, B. L., Cunningham, J. W., Docherty, K. F., Desai, A. S., Jhund, P. S., De Boer, R. A., Hernandez, A. F., Inzucchi, S. E., Kosiborod, M. N., Lam, C. S. P., Martinez, F. A., Shah, S. J., Petersson, M., Langkilde, A.-M., McMurray, J. J. V., Solomon, S. D. (2023) Outpatient worsening among patients with mildly reduced and preserved ejection fraction heart failure in the DELIVER trial. Circulation, 148, pp. 1735-1745. (doi: 10.1161/circulationaha.123.066506)

Pellicori, P., Cleland, J. G.F., Borentain, M., Taubel, J., Graham, F., Khan, J., Bruzzese, D., Kessler, P., McMurray, J. J.V., Voors, A. A., O’Connor, C. M., Teerlink, J. R., Felker, G. M. (2023) Impact of vasodilators on diuretic response in patients with congestive heart failure: a mechanistic trial of cimlanod (BMS‐986231) European Journal of Heart Failure, (doi: 10.1002/ejhf.3077)

Mc Causland, F. R., Claggett, B. L., Vaduganathan, M., Desai, A., Jhund, P., Vardeny, O., Fang, J. C., de Boer, R. A., Docherty, K. F., Hernandez, A. F., Inzucchi, S. E., Kosiborod, M. N., Lam, C. S. P., Martinez, F., Saraiva, J. F. K., McGrath, M. M., Shah, S. J., Verma, S., Langkilde, A. M., Petersson, M., McMurray, J. J. V., Solomon, S. D. (2023) Decline in estimated glomerular filtration rate after dapagliflozin in heart failure with mildly reduced or preserved ejection fraction: A prespecified secondary analysis of the DELIVER randomized clinical trial. JAMA Cardiology, 9, pp. 144-152. (doi: 10.1001/jamacardio.2023.4664)

McDowell, K., Adamson, C., Jackson, C., Campbell, R., Welsh, P., Petrie, M. C., McMurray, J. J.V., Jhund, P., Herring, N. (2023) Neuropeptide Y is elevated in heart failure and is an independent predictor of outcomes. European Journal of Heart Failure, (doi: 10.1002/ejhf.3085)

Chatur, S., Vaduganathan, M., Claggett, B. L., Mc Causland, F. R., Desai, A. S., Jhund, P. S., de Boer, R. A., Hernandez, A. F., Inzucchi, S. E., Kosiborod, M. N., Lam, C. S.P., Martinez, F. A., Shah, S. J., Sabatine, M. S., Kober, L., Ponikowski, P., Merkely, B., Petersson, M., Langkilde, A. M., McMurray, J. J.V., Solomon, S. D. (2023) Dapagliflozin in patients with heart failure and deterioration in renal function. Journal of the American College of Cardiology, 82, pp. 1854-1863. (doi: 10.1016/j.jacc.2023.08.026)

Hanratty, B., Wolters, A.T., Towers, A.M., Spilsbury, K., Meyer, J., Killett, A., Jones, L., Gordon, A., Burton, J.K., Akdur, G., Irvine, L., Warmoth, K., Liddle, J., Goodman, C. (2023) Data collection in care homes for older adults: A national survey in England. Journal of Long-Term Care, 2023, pp. 288-296. (doi: 10.31389/jltc.199)

Ostrominski, J. W., Thierer, J., Claggett, B. L., Miao, Z. M., Desai, A. S., Jhund, P. S., Kosiborod, M. N., Lam, C. S.P., Inzucchi, S. E., Martinez, F. A., de Boer, R. A., Hernandez, A. F., Shah, S. J., Petersson, M., Langkilde, A. M., McMurray, J. J.V., Solomon, S. D., Vaduganathan, M. (2023) Cardio-renal-metabolic overlap, outcomes, and dapagliflozin in heart failure with mildly reduced or preserved ejection fraction. JACC: Heart Failure, 11, pp. 1491-1503. (doi: 10.1016/j.jchf.2023.05.015)

Ray, R., Ford, I., Cleland, J. G.F., Graham, F., Ahmed, F. Z., Al-Mohammad, A., Cowburn, P. J., Critoph, C., Kalra, P. A., Lane, R. E., Ludman, A., Pellicori, P., Petrie, M. C., Robertson, M., Seed, A., Squire, I., Kalra, P. R. (2023) The impact of ferric derisomaltose on cardiovascular and non-cardiovascular events in patients with anemia, iron deficiency and heart failure with reduced ejection fraction. Journal of Cardiac Failure, (doi: 10.1016/j.cardfail.2023.10.006)

Ostrominski, J. W., Claggett, B. L., Packer, M., Pfeffer, M. A., Lam, C. S.P., Zile, M. R., Desai, A. S., Jhund, P. S., Lefkowitz, M., McMurray, J. J.V., Solomon, S. D., Vaduganathan, M. (2023) Duration of heart failure with preserved ejection fraction and outcomes with sacubitril/valsartan: insights from the PARAGON-HF trial. Journal of Cardiac Failure, 29, pp. 1494-1503. (doi: 10.1016/j.cardfail.2023.05.003)

Heerspink, H. J. L., Vart, P., Jongs, N., Neuen, B. L., Bakris, G., Claggett, B., Vaduganathan, M., McCausland, F., Docherty, K. F., Jhund, P. S.,, Solomon, S. D., Perkovic, V., McMurray, J. J. V. (2023) Estimated lifetime benefit of novel pharmacological therapies in patients with type 2 diabetes and chronic kidney disease: a joint analysis of randomized controlled clinical trials. Diabetes, Obesity and Metabolism, 25, pp. 3327-3336. (doi: 10.1111/dom.15232)

Butt, J. H., Lu, H., Kondo, T., Bachus, E., de Boer, R. A., Inzucchi, S. E., Jhund, P. S., Kosiborod, M. N., Lam, C. S.P., Martinez, F. A., Vaduganathan, M., Solomon, S. D., McMurray, J. J.V. (2023) Heart failure, chronic obstructive pulmonary disease and efficacy and safety of dapagliflozin in heart failure with mildly reduced or preserved ejection fraction: insights from DELIVER. European Journal of Heart Failure, 25, pp. 2078-2090. (doi: 10.1002/ejhf.3000)

Purcell, C., Purvis, A., Cleland, J. G.F., Cowie, A., Dalal, H. M., Ibbotson, T., Murphy, C., Taylor, R. S. (2023) Home-based cardiac rehabilitation for people with heart failure and their caregivers: a mixed-methods analysis of the roll out an evidence-based programme in Scotland (SCOT:REACH-HF study) European Journal of Cardiovascular Nursing, 22, pp. 804-813. (doi: 10.1093/eurjcn/zvad004)

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Towers, A.-M., Gordon, A., Wolters, A. T., Allan, S., Rand, S., Webster, L. A., Crellin, E., Brine, R. J., De Corte, K., Akdur, G., Irvine, L., Burton, J., Hanratty, B., Killett, A., Meyer, J., Jones, L., Goodman, C. (2023) Piloting of a minimum data set for older people living in care homes in England: protocol for a longitudinal, mixed-methods study. BMJ Open, 13, (doi: 10.1136/bmjopen-2023-071686)

Sullivan, M. K., Jani, B. D., Rutherford, E., Welsh, P., McConnachie, A., Major, R. W., McAllister, D., Nitsch, D., Mair, F. S., Mark, P. B., Lees, J. S. (2023) Potential impact of NICE guidelines on referrals from primary care to nephrology: a primary care database and prospective research study. British Journal of General Practice, 73, pp. e141-e147. (doi: 10.3399/BJGP.2022.0145)

Sykes, R. et al. (2023) Rationale and design of the effect of mineralocorticoid receptor antagonist therapy in patients with acute myocardial infarction or injury and non-obstructive coronary arteries: A registry-based, stratified-medicine, randomised, controlled trial. (doi: 10.1136/heartjnl-2022-BSCMR.26)

Savarese, G., von Haehling, S., Butler, J., Cleland, J. G.F., Ponikowski, P., Anker, S. D. (2023) Iron deficiency and cardiovascular disease. European Heart Journal, 44, pp. 14-27. (doi: 10.1093/eurheartj/ehac569)

Garimella, P. S., Du Toit, C., Le, N. N., Padmanabhan, S. (2023) A genomic deep field view of hypertension. Kidney International, 103, pp. 42-52. (doi: 10.1016/j.kint.2022.09.029)

Sykes, R. et al. (2023) Adjudicated myocarditis and multisystem illness trajectory in healthcare workers post-COVID-19. Open Heart, 10, (doi: 10.1136/openhrt-2022-002192)

Ouwerkerk, W., Tromp, J., Cleland, J. G.F., Angermann, C. E., Dahlstrom, U., Ertl, G., Hassanein, M., Perrone, S. V., Ghadanfar, M., Schweizer, A., Obergfell, A., Dickstein, K., Filippatos, G., Collins, S. P., Lam, C. S. (2023) Association of time‐to‐IV ‐furosemide with mortality in acute heart failure: data from REPORT‐HF. European Journal of Heart Failure, 25, pp. 43-51. (doi: 10.1002/ejhf.2708)

Mc Causland, F. R., Claggett, B. L., Vaduganathan, M., Desai, A. S., Jhund, P., de Boer, R. A., Docherty, K., Fang, J., Hernandez, A. F., Inzucchi, S. E., Kosiborod, M. N., Lam, C. S. P., Martinez, F., Saraiva, J. F. K., McGrath, M. M., Shah, S. J., Verma, S., Langkilde, A. M., Petersson, M., McMurray, J. J. V., Solomon, S. D. (2023) Dapagliflozin and kidney outcomes in patients with heart failure with mildly reduced or preserved ejection fraction. JAMA Cardiology, 8, pp. 56-65. (doi: 10.1001/jamacardio.2022.4210)

Petrie, M. C., Jhund, P. S., Connolly, E., Mark, P. B., MacDonald, M. R., Robertson, M., Anker, S. D., Bhandari, S., Farrington, K., Kalra, P. A., Wheeler, D. C., Tomson, C. R.V., Ford, I., McMurray, J. J.V., Macdougall, I. C. (2023) High-dose intravenous iron reduces myocardial infarction in patients on haemodialysis. Cardiovascular Research, 119, pp. 213-220. (doi: 10.1093/cvr/cvab317)

Taylor-Rowan, M., Nafisi, S., Owen, R., Duffy, R., Patel, A., Burton, J. K., Quinn, T. J. (2023) Informant-based screening tools for dementia: an overview of systematic reviews. Psychological Medicine, 53, pp. 580-589. (doi: 10.1017/S0033291721002002)

Manla, Y., Kuan, W., Clark, A. L., Cleland, J. G. F., Pellicori, P. (2023) Ketone bodies in acute heart failure: fuel for thought. Journal of Cardiac Failure, 29, pp. 42-44. (doi: 10.1016/j.cardfail.2022.11.002)

Ferreira, J. P., Cleland, J. G., Girerd, N., Bozec, E., Rossignol, P., Pellicori, P., Cosmi, F., Mariottoni, B., Solomon, S. D., Pitt, B., Pfeffer, M. A., Shah, A. M., Petutschnigg, J., Pieske, B., Edelmann, F., Zannad, F. (2023) Spironolactone effect on cardiac structure and function of patients with heart failure and preserved ejection fraction: a pooled analysis of three randomized trials. European Journal of Heart Failure, 25, pp. 108-113. (doi: 10.1002/ejhf.2726)

Welsh, P., Sattar, N. (2023) To apoB or not to apoB: new arguments, but basis for widespread implementation remains elusive. Clinical Chemistry, 69, pp. 3-5. (doi: 10.1093/clinchem/hvac183)

Padmanabhan, S., Du Toit, C., Dominiczak, A. F. (2023) Cardiovascular precision medicine – a pharmacogenomic perspective. Cambridge Prisms: Precision Medicine, 1, pp. 1-54. (doi: 10.1017/pcm.2023.17)

Taylor, A., Cushing, A., Dow, M., Anderson, J., McDowell, G., Lua, S., Manthe, M., Padmanabhan, S., Burns, S., McGinness, P., Lowe, D. J., Carlin, C. (2023) Long-term usage and improved clinical outcomes with adoption of a COPD digital support service: key findings from the RECEIVER trial. International Journal of Chronic Obstructive Pulmonary Disease, 18, pp. 1301-1318. (doi: 10.2147/COPD.S409116)

2022

Kalra, P. R., Cleland, J. G.F., Petrie, M. C., Thomson, E. A., Kalra, P. A., Squire, I. B., Ahmed, F. Z., Al-Mohammad, A., Cowburn, P. J., Foley, P. W.X., Graham, F. J., Japp, A. G., Lane, R. E., Lang, N. N., Ludman, A. J., Macdougall, I. C., Pellicori, P., Ray, R., Robertson, M., Seed, A., Ford, I. (2022) Intravenous ferric derisomaltose in patients with heart failure and iron deficiency in the UK (IRONMAN): an investigator-initiated, prospective, randomised, open-label, blinded-endpoint trial. Lancet, 400, pp. 2199-2209. (doi: 10.1016/S0140-6736(22)02083-9)

Bhandari, S., Mehta, S., Khwaja, A., Cleland, J. G.F., Ives, N., Brettell, E., Chadburn, M., Cockwell, P. (2022) Renin-angiotensin system inhibition in advanced chronic kidney disease. New England Journal of Medicine, 387, pp. 2021-2032. (doi: 10.1056/NEJMoa2210639)

Vardeny, O., Fang, J. C., Desai, A. S., Jhund, P. S., Claggett, B., Vaduganathan, M., de Boer, R. A., Hernandez, A. F., Lam, C. S. P., Inzucchi, S. E., Martinez, F. A., Kosiborod, M. N., DeMets, D., O’Meara, E., Zieroth, S., Comin-Colet, J., Drozdz, J., Chiang, C.-E., Kitakaze, M., Petersson, M., Lindholm, D., Langkilde, A. M., McMurray, J. J.V., Solomon, S. D. (2022) Dapagliflozin in heart failure with improved ejection fraction: a prespecified analysis of the DELIVER trial. Nature Medicine, 28, pp. 2504-2511. (doi: 10.1038/s41591-022-02102-9)

Yang, M., Butt, J. H., Kondo, T., Jering, K. S., Docherty, K. F., Jhund, P. S., de Boer, R. A., Claggett, B. L., Desai, A. S., Hernandez, A. F., Inzucchi, S. E., Kosiborod, M. N., Lam, C. S.P., Langkilde, A. M., Martinez, F. A., Petersson, M., Shah, S. J., Vaduganathan, M., Wilderäng, U., Solomon, S. D., McMurray, J. J.V. (2022) Dapagliflozin in patients with heart failure with mildly reduced and preserved ejection fraction treated with a mineralocorticoid receptor antagonist or sacubitril/valsartan. European Journal of Heart Failure, 24, pp. 2307-2319. (doi: 10.1002/ejhf.2722)

Monzo, L., Ferreira, J. P., Cleland, J. G.F., Pellicori, P., Mariottoni, B., Hazebroek, M. R., Collier, T. J., Cuthbert, J. J., Pieske, B., Petutschnigg, J., Ahmed, F. Z., Girerd, N., Clark, A. L., Cosmi, F., Staessen, J. A., Heymans, S., Rossignol, P., Zannad, F. (2022) Dyskalemia in people at increased risk for heart failure: findings from the heart ‘OMics’ in AGEing (HOMAGE) trial. ESC Heart Failure, 9, pp. 4352-4357. (doi: 10.1002/ehf2.14086)

Inzucchi, S. E., Claggett, B. L., Vaduganathan, M., Desai, A. S., Jhund, P. S., de Boer, R. A., Hernandez, A. F., Kosiborod, M. N., Lam, C. S. P., Martinez, F., Shah, S. J., Verma, S., Han, Y., Kerr Saraiva, J. F., Bengtsson, O., Petersson, M., Langkilde, A. M., McMurray, J. J.V., Solomon, S. D. (2022) Efficacy and safety of dapagliflozin in patients with heart failure with mildly reduced or preserved ejection fraction by baseline glycaemic status (DELIVER): a subgroup analysis from an international, multicentre, double-blind, randomised, placebo-controlled trial. Lancet Diabetes and Endocrinology, 10, pp. 869-881. (doi: 10.1016/S2213-8587(22)00308-4)

Pugliese, N. R., Pellicori, P., Filidei, F., De Biase, N., Maffia, P., Guzik, T. J., Masi, S., Taddei, S., Cleland, J. G.F. (2022) Inflammatory pathways in heart failure with preserved left ventricular ejection fraction: implications for future interventions. Cardiovascular Research, 118, pp. 3536-3555. (doi: 10.1093/cvr/cvac133)

Myhre, P. L., Vaduganathan, M., Claggett, B. L., Miao, Z. M., Jhund, P. S., de Boer, R. A., Hernandez, A. F., Inzucchi, S. E., Kosiborod, M. N., Lam, C. S.P., Martinez, F., Shah, S. J., Desai, A. S., Lindholm, D., Petersson, M., Langkilde, A. M., McMurray, J. J.V., Solomon, S. D. (2022) Influence of NT-proBNP on efficacy of dapagliflozin in heart failure with mildly reduced or preserved ejection fraction. JACC: Heart Failure, 10, pp. 902-913. (doi: 10.1016/j.jchf.2022.08.007)

Bracun, V., van Essen, B., Voors, A. A., van Veldhuisen, D. J., Dickstein, K., Zannad, F., Metra, M., Anker, S., Samani, N. J., Ponikowski, P., Filippatos, G., Cleland, J. G.F., Lang, C. C., Ng, L. L., Shi, C., de Wit, S., About Msallem, J. P., Meijers, W. C., Klip, I. T., van der Meer, P., de Boer, R. A. (2022) Insulin‐like growth factor binding protein 7 (IGFBP7), a link between heart failure and senescence. ESC Heart Failure, 9, pp. 4167-4176. (doi: 10.1002/ehf2.14120)

Kalra, P. R., Cleland, J. G. F., Petrie, M. C., Ahmed, F. Z., Foley, P. W. X., Kalra, P. A., Lang, N. N., Lane, R. E., Macdougall, I. C., Pellicori, P., Pope, M. T. B., Robertson, M., Squire, I. B., Thomson, E. A., Ford, I. (2022) Rationale and design of a randomised trial of intravenous iron in patients with heart failure. Heart, 108, pp. 1979-1985. (doi: 10.1136/heartjnl-2022-321304)

Burton, J. K., Ciminata, G., Lynch, E., Shenkin, S. D., Geue, C., Quinn, T. J. (2022) Understanding Pathways into Care homes using Data (UnPiCD study): a retrospective cohort study using national linked health and social care data. Age and Ageing, 51, (doi: 10.1093/ageing/afac304)

Kilpi, F., Soares, A. G., Clayton, G. L., Fraser, A., Welsh, P., Sattar, N., Nelson, S. M., Tilling, K., Lawlor, D. A. (2022) Changes in women’s physical function in mid-life by reproductive age and hormones: a longitudinal study. BMC Women's Health, 22, (doi: 10.1186/s12905-022-02070-9)

Vaduganathan, M., Claggett, B. L., Jhund, P., de Boer, R. A., Hernandez, A. F., Inzucchi, S. E., Kosiborod, M. N., Lam, C. S.P., Martinez, F., Shah, S. J., Desai, A. S., Lindholm, D., Petersson, M., Langkilde, A. M., McMurray, J. J.V., Solomon, S. D. (2022) Estimated event-free survival benefits with dapagliflozin in HF with mildly reduced or preserved ejection fraction. Journal of the American College of Cardiology, 80, pp. 1775-1784. (doi: 10.1016/j.jacc.2022.08.745)

Paterson, C., Hinterberg, M. A., Morrow, A. J., Sykes, R., Mangion, K., Welsh, P., McConnachie, A., Sattar, N., Berry, C., Williams, S. A. (2022) Utility of a Proteomic Surrogate for Cardiovascular Outcomes to Predict and Monitor COVID-19 Induced Myocarditis. (doi: 10.1161/circ.146.suppl_1.12132)

Kondo, T., Abdul-Rahim, A. H., Talebi, A., Abraham, W. T., Desai, A. S., Dickstein, K., Inzucchi, S. E., Køber, L., Kosiborod, M. N., Martinez, F. A., Packer, M., Petrie, M., Ponikowski, P., Rouleau, J. L., Sabatine, M. S., Swedberg, K., Zile, M. R., Solomon, S. D., Jhund, P. S., McMurray, J. J.V. (2022) Predicting stroke in heart failure and reduced ejection fraction without atrial fibrillation. European Heart Journal, 43, pp. 4469-4479. (doi: 10.1093/eurheartj/ehac487)

Zhang, L. et al. (2022) Aptamer proteomics for biomarker discovery in heart failure with reduced ejection fraction. Circulation, 146, pp. 1411-1414. (doi: 10.1161/CIRCULATIONAHA.122.061481)

Adamson, C. et al. (2022) Dapagliflozin for heart failure according to body mass index: the DELIVER trial. European Heart Journal, 43, pp. 4406-4417. (doi: 10.1093/eurheartj/ehac481)

Butt, J. H., Kondo, T., Jhund, P. S., Comin-Colet, J., de Boer, R. A., Desai, A. S., Hernandez, A. F., Inzucchi, S. E., Janssens, S. P., Kosiborod, M. N., Lam, C. S.P., Langkilde, A. M., Lindholm, D., Martinez, F., Petersson, M., Shah, S. J., Thierer, J., Vaduganathan, M., Verma, S., Wilderäng, U., Claggett, B. C., Solomon, S. D., McMurray, J. J.V. (2022) Dapagliflozin, atrial fibrillation, and heart failure with mildly reduced or preserved ejection fraction in DELIVER. Journal of the American College of Cardiology, 80, pp. 1705-1717. (doi: 10.1016/j.jacc.2022.08.718)

Butler, J. et al. (2022) Patiromer for the management of hyperkalemia in heart failure with reduced ejection fraction: the DIAMOND trial. European Heart Journal, 43, pp. 4362-4373. (doi: 10.1093/eurheartj/ehac401)

Pellicori, P., Kalra, P. R., Clark, A. L., Friday, J., Cleland, J. G. F. (2022) Chronic kidney disease (CKD) and CKD-ism in heart failure – what a mess! European Journal of Heart Failure, 24, pp. 2196-2198. (doi: 10.1002/ejhf.2696)

Inciardi, R. M., Pagnesi, M., Lombardi, C. M., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G. S., Lang, C. C., Ng, L. L., Pellicori, P., Ponikowski, P., Samani, N. J., Zannad, F., van Veldhuisen, D. J., Solomon, S. D., Voors, A. A., Metra, M. (2022) Clinical implications of left atrial changes after optimization of medical therapy in patients with heart failure. European Journal of Heart Failure, 24, pp. 2131-2139. (doi: 10.1002/ejhf.2593)

Karusheva, Y., Ratcliff, M., Mörseburg, A., Barker, P., Melvin, A., Sattar, N., Burling, K., Backmark, A., Roth, R., Jermutus, L., Guiu-Jurado, E., Blueher, M., Welsh, P., Hyvönen, M., O’Rahilly, S. (2022) Common H202D variant in GDF-15 does not affect its bioactivity but can significantly interfere with measurement of its circulating levels. Journal of Applied Laboratory Medicine, 7, pp. 1388-1400. (doi: 10.1093/jalm/jfac055)

Lim, S., Cox, N., Hale, M., White, L., Welch, C., Lochlainn, M. N., Burton, J. K., Richardson, S. J., Walesby, K., Willott, R., Makin, S., Taylor, J. (2022) Engagement in research during specialist geriatric medicine training: results of a national trainee survey. Clinical Medicine, 22, pp. 553-558. (doi: 10.7861/clinmed.2022-0283)

Sun, G., Yafasova, A., Andersson, C., McMurray, J. J.V., Jhund, P. S., Docherty, K. F., Faurschou, M., Nielsen, C. T., Schou, M., Gislason, G. H., Torp-Pedersen, C., Fosbøl, E. L., Køber, L., Butt, J. H. (2022) Gender- and age-specific rates of heart failure and other adverse cardiovascular outcomes in systemic sclerosis. Rheumatology, 61, pp. 4374-4383. (doi: 10.1093/rheumatology/keac072)

Jhund, P. S. (2022) Implementing the evidence – the true summit of evidence based care and the false peak of guidelines. European Journal of Heart Failure, 24, pp. 2090-2092. (doi: 10.1002/ejhf.2712)

Adamson, C., Jhund, P. S., McMurray, J. J.V. (2022) Reply to 'the 50 shades of bilirubin'. Letter regarding the article 'liver tests and outcomes in heart failure with reduced ejection fraction: findings from DAPA-HF' European Journal of Heart Failure, 24, pp. 2206-2207. (doi: 10.1002/ejhf.2683)

Mary, S., Boder, P., Padmanabhan, S., McBride, M. W., Graham, D., Delles, C., Dominiczak, A. F. (2022) The role of uromodulin in salt-sensitive hypertension. Hypertension, 79, pp. 2419-2429. (doi: 10.1161/HYPERTENSIONAHA.122.19888)

Salah, H. M., Goldberg, L. R., Molinger, J., Felker, G. M., Applefeld, W., Rassaf, T., Tedford, R. J., Mirro, M., Cleland, J. G.F., Fudim, M. (2022) Diaphragmatic function in cardiovascular disease: JACC review topic of the week. Journal of the American College of Cardiology, 80, pp. 1647-1659. (doi: 10.1016/j.jacc.2022.08.760)

Butt, J. H. et al. (2022) Efficacy and safety of dapagliflozin according to frailty in patients with heart failure: a prespecified analysis of the DELIVER trial. Circulation, 146, pp. 1210-1224. (doi: 10.1161/CIRCULATIONAHA.122.061754)

Lota, A. S. et al. (2022) Genetic architecture of acute myocarditis and the overlap with inherited cardiomyopathy. Circulation, 146, pp. 1123-1134. (doi: 10.1161/CIRCULATIONAHA.121.058457)

Ford, T. J., Adamson, C., Morrow, A. J., Rocchiccioli, P., Collison, D., McCartney, P. J., Shaukat, A., Lindsay, M., Good, R., Watkins, S., Eteiba, H., Robertson, K., Berry, C., Oldroyd, K. G., McEntegart, M. (2022) Coronary artery perforations: Glasgow Natural History Study of Covered Stent Coronary Interventions (GNOCCI) Study. Journal of the American Heart Association, 11, (doi: 10.1161/JAHA.121.024492)

Cunningham, J. W., Vaduganathan, M., Claggett, B. L., Kulac, I. J., Desai, A. S., Jhund, P. S., de Boer, R. A., DeMets, D., Hernandez, A. F., Inzucchi, S. E., Kosiborod, M. N., Lam, C. S.P., Martinez, F., Shah, S. J., McGrath, M. M., O’Meara, E., Wilderäng, U., Lindholm, D., Petersson, M., Langkilde, A. M., McMurray, J. J.V., Solomon, S. D. (2022) Dapagliflozin in patients recently hospitalized with heart failure and mildly reduced or preserved ejection fraction. Journal of the American College of Cardiology, 80, pp. 1302-1310. (doi: 10.1016/j.jacc.2022.07.021)

Shah, A. M., Claggett, B., Prasad, N., Li, G., Volquez, M., Jering, K., Cikes, M., Kovacs, A., Mullens, W., Nicolau, J. C., Køber, L., van der Meer, P., Jhund, P. S., Ibram, G., Lefkowitz, M., Zhou, Y., Solomon, S. D., Pfeffer, M. A. (2022) Impact of sacubitril/valsartan compared to ramipril on cardiac structure and function following acute myocardial infarction: The PARADISE-MI echocardiographic sub-study. Circulation, 146, pp. 1067-1081. (doi: 10.1161/CIRCULATIONAHA.122.059210)

Desai, A. S., Jhund, P. S., Claggett, B. L., Vaduganathan, M., Miao, Z. M., Kondo, T., Barkoudah, E., Brahimi, A., Connolly, E., Finn, P., Lang, N. N., Mc Causland, F. R., McGrath, M., Petrie, M. C., McMurray, J. J.V., Solomon, S. D. (2022) Effect of dapagliflozin on cause-specific mortality in patients with heart failure across the spectrum of ejection fraction. JAMA Cardiology, 7, pp. 1227-1234. (doi: 10.1001/jamacardio.2022.3736)

Baumhove, L., Tromp, J., Figarska, S., van Essen, B. J., Anker, S. D., Dickstein, K., Cleland, J. G., Lang, C. C., Filippatos, G., Ng, L. L., Samani, N. J., Metra, M., van Veldhuisen, D. J., Lam, C. S.P., Voors, A. A., van der Meer, P. (2022) Heart failure with normal LVEF in BIOSTAT-CHF. International Journal of Cardiology, 364, pp. 85-90. (doi: 10.1016/j.ijcard.2022.05.054)

Bayes‐Genis, A. et al. (2022) Biomarkers in heart failure clinical trials. A review from the Biomarkers Working Group of the Heart Failure Association of the European Society of Cardiology. European Journal of Heart Failure, 24, pp. 1767-1777. (doi: 10.1002/ejhf.2675)

Jhund, P. S. (2022) Cardiopulmonary functional capacity: another piece of the puzzle of SGLT2 inhibition in heart failure? European Journal of Heart Failure, 24, pp. 1827-1828. (doi: 10.1002/ejhf.2672)

Núñez, J. et al. (2022) Congestion in heart failure: a circulating biomarker‐based perspective. European Journal of Heart Failure, 24, pp. 1751-1766. (doi: 10.1002/ejhf.2664)

Ostrominski, J. W., Vaduganathan, M., Claggett, B. L., de Boer, R. A., Desai, A. S., Dobreanu, D., Hernandez, A. F., Inzucchi, S. E., Jhund, P. S., Kosiborod, M., Lam, C. S.P., Langkilde, A. M., Lindholm, D., Martinez, F. A., O'Meara, E., Petersson, M., Shah, S. J., Thierer, J., McMurray, J. J.V., Solomon, S. D. (2022) Dapagliflozin and New York Heart Association functional class in heart failure with mildly reduced or preserved ejection fraction: the DELIVER trial. European Journal of Heart Failure, 24, pp. 1892-1901. (doi: 10.1002/ejhf.2652)

Kazmi, S., Kambhampati, C., Cleland, J. G.F., Cuthbert, J., Kazmi, K. S., Pellicori, P., Rigby, A. S., Clark, A. L. (2022) Dynamic risk stratification using Markov chain modelling in patients with chronic heart failure. ESC Heart Failure, 9, pp. 3009-3018. (doi: 10.1002/ehf2.14028)

Peikert, A., Martinez, F. A., Vaduganathan, M., Claggett, B. L., Kulac, I. J., Desai, A. S., Jhund, P. S., de Boer, R. A., DeMets, D., Hernandez, A. F., Inzucchi, S. E., Kosiborod, M. N., Lam, C. S.P., Shah, S. J., Katova, T., Merkely, B., Vardeny, O., Wilderäng, U., Lindholm, D., Petersson, M., Langkilde, A.-M., McMurray, J. J.V., Solomon, S. D. (2022) Efficacy and safety of dapagliflozin in heart failure with mildly reduced or preserved ejection fraction according to age: the DELIVER trial. Circulation: Heart Failure, 15, pp. 934-943. (doi: 10.1161/CIRCHEARTFAILURE.122.010080)

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Rossing, P. et al. (2022) Dapagliflozin and new-onset type 2 diabetes in patients with chronic kidney disease or heart failure: pooled analysis of the DAPA-CKD and DAPA-HF trials. Lancet Diabetes and Endocrinology, 10, pp. 24-34. (doi: 10.1016/S2213-8587(21)00295-3)

Cuthbert, J.J., Brown, O.I., Urbinati, A., Pan, D., Pellicori, P., Dobbs, K., Bulemfu, J., Kazmi, S., Sokoreli, I., Pauws, S.C., Riistama, J.M., Cleland, J.G.F., Clark, A.L. (2022) Hypochloraemia following admission to hospital with heart failure is common and associated with an increased risk of readmission or death: a report from OPERA-HF. European Heart Journal: Acute Cardiovascular Care, 11, pp. 43-52. (doi: 10.1093/ehjacc/zuab097)

Ferreira, J. P., Cleland, J. G., Lam, C. S.P., Anker, S. D., Mehra, M. R., van Veldhuisen, D. J., Byra, W. M., LaPolice, D. A., Greenberg, B., Zannad, F. (2022) New-onset atrial fibrillation in patients with worsening heart failure and coronary artery disease: an analysis from the COMMANDER-HF trial. Clinical Research in Cardiology, 111, pp. 50-59. (doi: 10.1007/s00392-021-01891-2)

Rodríguez-Gómez, I., Gray, S. R., Ho, F. K., Petermann-Rocha, F., Welsh, P., Cleland, J., Iliodromiti, S., Ara, I., Pell, J., Sattar, N., Ferguson, L. D., Celis-Morales, C. (2022) Osteoporosis and its association with cardiovascular disease, respiratory disease, and cancer: findings from the UK Biobank prospective cohort study. Mayo Clinic Proceedings, 97, pp. 110-121. (doi: 10.1016/j.mayocp.2021.07.019)

Lam, P. H., Keramida, K., Filippatos, G. S., Gupta, N., Faselis, C., Deedwania, P., George, B., Iskandrian, A., Cleland, J. G.F., Choudhary, G., Wu, W.-C., Morgan, C. J., Fonarow, G. C., Ahmed, A. (2022) Right ventricular ejection fraction and beta-blocker effect in heart failure with reduced ejection fraction: Beta-blocker and outcomes in HFrEF by RVEF. Journal of Cardiac Failure, 28, pp. 65-70. (doi: 10.1016/j.cardfail.2021.07.026)

Romaine, S. P. R., Denniff, M., Codd, V., Nath, M., Koekemoer, A., Anker, S. D., Cleland, J. G., Filippatos, G., Levin, D., Metra, M., Mordi, I. R., Ouwerkerk, W., ter Maaten, J. M., van Veldhuisen, D. J., Zannad, F., Ng, L. L., van der Harst, P., Lang, C. C., Voors, A. A., Nelson, C. P., Samani, N. J. (2022) Telomere length is independently associated with all-cause mortality in chronic heart failure. Heart, 108, pp. 124-129. (doi: 10.1136/heartjnl-2020-318654)

Morrow, A., Gray, S. R., Bayes, H. K., Sykes, R., McGarry, E., Anderson, D., Boiskin, D., Burke, C., Cleland, J. G. F., Goodyear, C., Ibbotson, T., Lang, C. C., McConnachie, A., Mair, F., Mangion, K., Patel, M., Sattar, N., Taggart, D., Taylor, R., Dawkes, S., Berry, C. (2022) Prevention and early treatment of the long-term physical effects of COVID-19 in adults: design of a randomised controlled trial of resistance exercise—CISCO-21. Trials, 23, (doi: 10.1186/s13063-022-06632-y)

Welsh, P., Kimenai, D. M., Marioni, R. E., Hayward, C., Campbell, A., Porteous, D., Mills, N. L., O’Rahilly, S., Sattar, N. (2022) Reference ranges for GDF-15, and risk factors associated with GDF-15, in a large general population cohort. Clinical Chemistry and Laboratory Medicine, 60, pp. 1820-1829. (doi: 10.1515/cclm-2022-0135)

2021

Mooney, L., Hawkins, N. M., Jhund, P. S., Redfield, M. M., Muthiah Vaduganathan, M., Desai, A. S., Rouleau, J. L., Minamisawa, M., Shah, A. M., Lefkowitz, M. P., Zile, M. R., Van Veldhuisen, D. J., Pfeffer, M. A., Anand, I. S., Maggioni, A. P., Senni, M., Claggett, B. L., Solomon, S. D., McMurray, J. J. V. (2021) Impact of chronic obstructive pulmonary disease in patients with heart failure with preserved ejection fraction: insights from PARAGON‐HF. Journal of the American Heart Association, 10, (doi: 10.1161/JAHA.121.021494)

Petermann-Rocha, F., Lyall, D. M., Gray, S. R., Gill, J. M.R., Sattar, N., Welsh, P., Quinn, T. J., Stewart, W., Pell, J. P., Ho, F. K., Celis-Morales, C. (2021) Dose-response association between device-measured physical activity and incident dementia: a prospective study from UK Biobank. BMC Medicine, 19, (doi: 10.1186/s12916-021-02172-5)

Macpherson, J. M., Gray, S. R., Ip, P., McCallum, M., Hanlon, P., Welsh, P., Chan, K. L., Mair, F. S., Celis-Morales, C., Minnis, H., Pell, J. P., Ho, F. K. (2021) Child maltreatment and incident mental disorders in middle and older ages: a retrospective UK Biobank cohort study. Lancet Regional Health - Europe, 11, (doi: 10.1016/j.lanepe.2021.100224)

Butt, J. H., Adamson, C., Docherty, K. F., de Boer, R. A., Petrie, M. C., Inzucchi, S. E., Kosiborod, M. N., Maria Langkilde, A., Lindholm, D., Martinez, F. A., Bengtsson, O., Schou, M., O’Meara, E., Ponikowski, P., Sabatine, M. S., Sjöstrand, M., Solomon, S. D., Jhund, P. S., McMurray, J. J.V., Køber, L. (2021) Efficacy and safety of dapagliflozin in heart failure with reduced ejection fraction according to N-terminal pro-B-type natriuretic peptide: insights from the DAPA-HF trial. Circulation: Heart Failure, 14, (doi: 10.1161/CIRCHEARTFAILURE.121.008837)

Diamant, M. J., Andrade, J. G., Virani, S. A., Jhund, P. S., Petrie, M. C., Hawkins, N. M. (2021) Heart failure and atrial flutter: a systematic review of current knowledge and practices. ESC Heart Failure, 8, pp. 4484-4496. (doi: 10.1002/ehf2.13526)

Welsh, P., Welsh, C., Celis-Morales, C. A., Brown, R., Ho, F. K., Ferguson, L. D., Mark, P. B., Lewsey, J., Gray, S. R., Lyall, D. M., Gill, J. M.R., Pell, J. P., de Lemos, J. A., Willeit, P., Sattar, N. (2021) Lipoprotein(a) and cardiovascular disease: prediction, attributable risk fraction and estimating benefits from novel interventions. European Journal of Preventive Cardiology, 28, pp. 1991-2000. (doi: 10.1093/eurjpc/zwaa063)

Desai, A. S., Vaduganathan, M., Cleland, J. G., Claggett, B. L., Barkoudah, E., Finn, P., McCausland, F. R., Yilmaz, M. B., Lefkowitz, M., Shi, V., Pfeffer, M. A., McMurray, J. J.V., Soloman, S. D. (2021) Mode of death in patients with heart failure and preserved ejection fraction: insights from PARAGON-HF. Circulation: Heart Failure, 14, (doi: 10.1161/CIRCHEARTFAILURE.121.008597)

Ferreira, J. P., Girerd, N., Rocca, H.-P. B.-L., Pellicori, P., Cleland, J. G., Rossignol, P., Zannad, F. (2021) No influence of spironolactone on plasma concentrations of angiotensin-converting enzyme 2: Findings from the HOMAGE randomized trial = Pas d’influence de la spironolactone sur les concentrations plasmatiques de l’enzyme de conversion de l’angiotensine 2 : résultats de l’essai randomisé HOMAGE. Archives of Cardiovascular Diseases, 114, pp. 814-817. (doi: 10.1016/j.acvd.2021.10.003)

Lota, A. S., Tsao, A., Owen, R., Halliday, B. P., Auger, D., Vassiliou, V. S., Tayal, U., Almogheer, B., Vilches, S., Al-Balah, A., Patel, A., Mouy, F., Buchan, R., Newsome, S., Gregson, J., Ware, J. S., Cook, S. A., Cleland, J. G.F., Pennell, D. J., Prasad, S. K. (2021) Prognostic significance of nonischaemic myocardial fibrosis in patients with normal left ventricular volumes and ejection-fraction. JACC: Cardiovascular Imaging, 14, pp. 2353-2365. (doi: 10.1016/j.jcmg.2021.05.016)

Kulkarni, S., Welsh, P., Ali, M., Petrie, J. R. (2021) Quality of life in people with type 2 diabetes; a study in a multi-ethnic clinical trial population. British Journal of Diabetes, 21, pp. 210-215. (doi: 10.15277/bjd.2021.315)

Lumbers, R. T. et al. (2021) The genomics of heart failure: design and rationale of the HERMES consortium. ESC Heart Failure, 8, pp. 5531-5541. (doi: 10.1002/ehf2.13517)

Wannamethee, S. G., Welsh, P., Papacosta, O., Lennon, L., Whincup, P. (2021) Vitamin D deficiency, impaired lung function and total and respiratory mortality in a cohort of older men: cross-sectional and prospective findings from the British Regional Heart Study. BMJ Open, 11, (doi: 10.1136/bmjopen-2021-051560)

Mark, P. B., Jhund, P. S., Walters, M. R., Petrie, M. C., Power, A., White, C., Robertson, M., Connolly, E., Anker, S. D., Bhandari, S., Farrington, K., Kalra, P. A., Tomson, C. R.V., Wheeler, D. C., Winearls, C. G., McMurray, J. J.V., Macdougall, I. C., Ford, I. (2021) Stroke in hemodialysis patients randomized to different intravenous iron strategies: a prespecified analysis from the PIVOTAL trial. Kidney360, 2, pp. 1761-1769. (doi: 10.34067/KID.0004272021)

Berry, C. et al. (2021) Post-COVID-19 illness trajectory: a multisystem investigation [Pre-print] Research Square, (doi: 10.21203/rs.3.rs-1053331/v1)

Morrow, A. et al. (2021) Rationale and design of the Medical Research Council Precision medicine with Zibotentan in microvascular angina (PRIZE) trial MRI sub-study. (doi: 10.1136/heartjnl-2021-BSCMR.3)

Täger, T., Atar, D., Agewall, S., Katus, H. A., Grundtvig, M., Cleland, J. G.F., Clark, A. L., Fröhlich, H., Frankenstein, L. (2021) Comparative efficacy of sodium-glucose cotransporter-2 inhibitors (SGLT2i) for cardiovascular outcomes in type 2 diabetes: a systematic review and network meta-analysis of randomised controlled trials. Heart Failure Reviews, 26, pp. 1421-1435. (doi: 10.1007/s10741-020-09954-8)

Docherty, K. F., Jhund, P. S., Claggett, B., Ferreira, J. P., Bengtsson, O., Inzucchi, S. E., Køber, L., Kosiborod, M. N., Langkilde, A. M., Martinez, F. A., Ponikowski, P., Sabatine, M. S., Sjöstrand, M., Solomon, S. D., McMurray, J. J.V. (2021) Extrapolating long-term event-free and overall survival with dapagliflozin in patients with heart failure and reduced ejection fraction: an exploratory analysis of a phase 3 randomized clinical trial. JAMA Cardiology, 6, pp. 1298-1305. (doi: 10.1001/jamacardio.2021.2632)

Sullivan, M. K., Jani, B. D., Lees, J. S., Welsh, C. E., McConnachie, A., Stanley, B., Welsh, P., Nicholl, B. I., Lyall, D. M., Carrero, J.-J., Nitsch, D., Sattar, N., Mair, F. S., Mark, P. B. (2021) Multimorbidity and the risk of major adverse kidney events: findings from the UK Biobank cohort. Clinical Kidney Journal, 14, pp. 2409-2419. (doi: 10.1093/ckj/sfab079)

Burton, J. K., Craig, L., Yong, S. Q., Siddiqi, N., Teale, E. A., Woodhouse, R., Barugh, A. J., Shepherd, A. M., Brunton, A., Freeman, S. C., Sutton, A. J., Quinn, T. J. (2021) Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients. Cochrane Database of Systematic Reviews, 2021, (doi: 10.1002/14651858.CD013307.pub3)

Pan, D., Pellicori, P., Dobbs, K., Bulemfu, J., Sokoreli, I., Urbinati, A., Brown, O., Sze, S., Rigby Cstat, A. R., Kazmi, S., Riistama, J. M., Cleland, J. G.F., Clark, A. L. (2021) Prognostic value of the chest x-ray in patients hospitalised for heart failure. Clinical Research in Cardiology, 110, pp. 1743-1756. (doi: 10.1007/s00392-021-01836-9)

Burton, J. K., Walker, M. F. (2021) Supporting stroke survivors living in care homes: challenges and opportunities for practice development and research. Age and Ageing, 50, pp. 1901-1903. (doi: 10.1093/ageing/afab180)

Colaco, K., Lee, K.-A., Akhtari, S., Winer, R., Welsh, P., Sattar, N., McInnes, I. B., Chandran, V., Harvey, P., Cook, R. J., Gladman, D. D., Piguet, V., Eder, L. (2021) Targeted metabolomic profiling and prediction of cardiovascular events: a prospective study of patients with psoriatic arthritis and psoriasis. Annals of the Rheumatic Diseases, 80, pp. 1429-1435. (doi: 10.1136/annrheumdis-2021-220168)

Cuthbert, J. J., Pellicori, P., Flockton, R., Kallvikbacka-Bennett, A., Khan, J., Rigby, A. S., Girerd, N., Zannad, F., Cleland, J. G.F., Clark, A. L. (2021) The prevalence and clinical associations of ultrasound measures of congestion in patients at risk of developing heart failure. European Journal of Heart Failure, 23, pp. 1831-1840. (doi: 10.1002/ejhf.2353)

Shah, P., Abel, A. A.I., Boyalla, V., Pellicori, P., Kallvikbacka-Bennett, A., Sze, S., Cleland, J. G.F., Clark, A. L. (2021) A comparison of non-invasive methods of measuring body composition in patients with heart failure: a report from SICA-HF. ESC Heart Failure, 8, pp. 3929-3934. (doi: 10.1002/ehf2.13402)

Papageorgiou, V., Jones, K., Halliday, B. P., Mindham, R., Bruton, J., Wassall, R., Cleland, J. G.F., Prasad, S. K., Ward, H. (2021) A qualitative exploration of participant and investigator perspectives from the TRED-HF trial. ESC Heart Failure, 8, pp. 3760-3768. (doi: 10.1002/ehf2.13524)

Touyz, R. M., Boyd, M. O.E., Guzik, T., Padmanabhan, S., McCallum, L., Delles, C., Mark, P. B., Petrie, J. R., Rios, F., Montezano, A. C., Sykes, R., Berry, C. (2021) Cardiovascular and renal risk factors and complications associated with COVID-19. CJC Open, 3, pp. 1257-1272. (doi: 10.1016/j.cjco.2021.05.020)

Meijers, W. C., Bayes‐Genis, A., Mebazaa, A., Bauersachs, J., Cleland, J. J.G., Coats, A. J.S., Januzzi, J. L., Maisel, A. S., McDonald, K., Mueller, T., Richards, A. M., Seferovic, P., Mueller, C., de Boer, R. A. (2021) Circulating heart failure biomarkers beyond natriuretic peptides: review from the Biomarker Study Group of the Heart Failure Association (HFA), European Society of Cardiology (ESC) European Journal of Heart Failure, 23, pp. 1610-1632. (doi: 10.1002/ejhf.2346)

Dalal, H., Taylor, R. S., Cleland, J. G. (2021) Correspondence to European Heart Journal—Quality of Care and Clinical Outcomes in response to paper by Thomas, M. et al. 2021: Predicting the EQ-5D from the Kansas City Cardiomyopathy Questionnaire (KCCQ) in patients with heart failures. European Heart Journal: Quality of Care and Clinical Outcomes, 7, pp. e7. (doi: 10.1093/ehjqcco/qcab033)

Adamson, C., Jhund, P. S., Docherty, K. F., Bělohlávek, J., Chiang, C.‐E., Diez, M., Drożdż, J., Dukát, A., Howlett, J., Ljungman, C. E.A., Petrie, M. C., Schou, M., Inzucchi, S. E., Køber, L., Kosiborod, M. N., Martinez, F. A., Ponikowski, P., Sabatine, M. S., Solomon, S. D., Bengtsson, O., Langkilde, A. M., Lindholm, D., Sjöstrand, M., McMurray, J. J.V. (2021) Efficacy of dapagliflozin in heart failure with reduced ejection fraction according to body mass index. European Journal of Heart Failure, 23, pp. 1662-1672. (doi: 10.1002/ejhf.2308)

Jani, B. D., Nicholl, B. I., Hanlon, P., Mair, F. S., Gill, J. M.R., Gray, S. R., Celis-Morales, C. A., Ho, F. K., Lyall, D. M., Anderson, J. J., Hastie, C. E., Bailey, M. E.S., Foster, H., Pell, J. P., Welsh, P., Sattar, N. (2021) Family history of diabetes and risk of SARS-COV-2 in UK Biobank: a prospective cohort study. Endocrinology, Diabetes and Metabolism, 4, (doi: 10.1002/edm2.283)

Ferreira, J. P., Cleland, J. G., Lam, C. S.P., Anker, S. D., Mehra, M. R., van Veldhuisen, D. J., Byra, W. M., La Police, D. A., Pitt, B., Greenberg, B., Zannad, F. (2021) Heart failure re-hospitalizations and subsequent fatal events in coronary artery disease: insights from COMMANDER-HF, EPHESUS, and EXAMINE. Clinical Research in Cardiology, 110, pp. 1554-1563. (doi: 10.1007/s00392-021-01830-1)

Raafs, A. et al. (2021) Identification of sex‐specific biomarkers predicting new‐onset heart failure. ESC Heart Failure, 8, pp. 3512-3520. (doi: 10.1002/ehf2.13476)

Pagnesi, M., Adamo, M., Sama, I. E., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G. S., Lang, C. C., Ng, L. L., Ponikowski, P., Ravera, A., Samani, N. J., Zannad, F., van Veldhuisen, D. J., Voors, A. A., Metra, M. (2021) Impact of mitral regurgitation in patients with worsening heart failure: insights from BIOSTAT-CHF. European Journal of Heart Failure, 23, pp. 1750-1758. (doi: 10.1002/ejhf.2276)

Rush, C. J., Berry, C., Oldroyd, K. G., Rocchiccioli, J. P., Lindsay, M. M., Touyz, R. M., Murphy, C. L., Ford, T. J., Sidik, N., McEntegart, M. B., Lang, N. N., Jhund, P. S., Campbell, R. T., McMurray, J. J.V., Petrie, M. C. (2021) Prevalence of coronary artery disease and coronary microvascular dysfunction in patients with heart failure with preserved ejection fraction. JAMA Cardiology, 6, pp. 1130-1143. (doi: 10.1001/jamacardio.2021.1825)

Anderson, J. J., Ho, F. K., Niedzwiedz, C. L., Katikireddi, V., Celis-Morales, C., Iliodromiti, S., Welsh, P., Pellicori, P., Demou, E., Hastie, C. E., Lyall, D. M., Gray, S. R., Forbes, J. F., Gill, J. M.R., Mackay, D. F., Berry, C., Cleland, J. G.F., Sattar, N., Pell, J. P. (2021) Remote history of VTE is associated with severe COVID-19 in middle and older age: UK Biobank cohort study. Journal of Thrombosis and Haemostasis, 19, pp. 2533-2538. (doi: 10.1111/jth.15452)

Graham, F. J., Pellicori, P., Cleland, J. G.F., Clark, A. L. (2021) Reply to the letter regarding the article 'Natural history and prognostic significance of iron deficiency and anaemia in ambulatory patients with chronic heart failure' European Journal of Heart Failure, 23, pp. 1800-1801. (doi: 10.1002/ejhf.2304)

Al-Ozairi, E., Brown, R., Hamdan, Y., Alabdullah, L., Voase, N., Al Kandari, J., Alsaeed, D., Al Ozairi, A., Hasan, A., Al-Mulla, F., Katikireddi, S. V., Gray, S. R., Gill, J. M.R., Celis-Morales, C. A., Sattar, N., Welsh, P. (2021) Risk of mortality among inpatients with COVID-19 and type 2 diabetes: national data from Kuwait. Endocrinology, Diabetes and Metabolism, 4, (doi: 10.1002/edm2.287)

Camafort, M., Jhund, P. S., Formiga, F., Castro- Salomó, A., Arévalo-Lorido, J. C., Sobrino-Martínez, J., Manzano, L., Diez-Manglano, J., Aramburu, O., Pérez-Barquero, M. M. (2021) Utilidad pronóstica de las cifras ambulatorias de presión arterial en pacientes de edad avanzada con insuficiencia cardíaca. Resultados del estudio DICUMAP = Prognostic value of ambulatory blood pressure values in elderly patients with heart failure. Results of the DICUMAP study. Revista Clínica Española, 221, pp. 433-440. (doi: 10.1016/j.rce.2020.11.010)

Brown, R., Lewsey, J., Wild, S., Logue, J., Welsh, P. (2021) Associations of statin adherence and lipid targets with adverse outcomes in myocardial infarction survivors: a retrospective cohort study. BMJ Open, 11, (doi: 10.1136/bmjopen-2021-054893)

Curtain, J. P., Docherty, K. F., Jhund, P. S., Petrie, M. C., Inzucchi, S. E., Køber, L., Kosiborod, M. N., Martinez, F., Ponikowski, P., Sabatine, M. S., Bengtsson, O., Langkilde, A. M., Sjöstrand, M., Solomon, S. D., McMurray, J. J.V. (2021) Effect of dapagliflozin on ventricular arrhythmias, resuscitated cardiac arrest, or sudden death in DAPA-HF. European Heart Journal, 42, pp. 3727-3738. (doi: 10.1093/eurheartj/ehab560)

Jackson, A. M., Jhund, P. S., Anand, I. S., Düngen, H.-D., Lam, C. S.P., Lefkowitz, M. P., Linssen, G., Lund, L. H., Maggioni, A. P., Pfeffer, M. A., Rouleau, J. L., Saraiva, J. F.K., Senni, M., Vardeny, O., Wijkman, M. O., Yilmarz, M. B., Saito, Y., Zile, M. R., Solomon, S. D., McMurray, J. J.V. (2021) Sacubitril–valsartan as a treatment for apparent resistant hypertension in patients with heart failure and preserved ejection fraction. European Heart Journal, 42, pp. 3741-3752. (doi: 10.1093/eurheartj/ehab499)

Stoumpos, S., Rankin, A., Hall Barrientos, P., Mangion, K., McGregor, E., Thomson, P. C., Stevenson, K., Welsh, P., Kasthuri, R., Kingsmore, D., Roditi, G., Mark, P. B. (2021) Interrogating the haemodynamic effects of haemodialysis arteriovenous fistula on cardiac structure and function. Scientific Reports, 11, (doi: 10.1038/s41598-021-97625-5)

Cleland, J. G.F., Pellicori, P. (2021) To master heart failure, first master congestion. Lancet, 398, pp. 935-936. (doi: 10.1016/S0140-6736(21)01914-0)

Ferreira, J. P., Ouwerkerk, W., Santema, B. T., van Veldhuisen, D. J., Lang, C. C., Ng, L. L., Anker, S. D., Dickstein, K., Metra, M., Cleland, J. G.F., Nilesh, S. J., Filippatos, G., Aboumsallem, J.-P., de Boer, R. A., Figarska, S., Sama, I. E., Voors, A. A., Zannad, F. (2021) Differences in biomarkers and molecular pathways according to age for patients with HFrEF. Cardiovascular Research, 117, pp. 2228-2236. (doi: 10.1093/cvr/cvaa279)

Zhou, Z., Macpherson, J., Gray, S. R., Gill, J. M.R., Welsh, P., Celis-Morales, C., Sattar, N., Pell, J. P., Ho, F. K. (2021) Are people with metabolically healthy obesity really healthy? A prospective cohort study of 381,363 UK Biobank participants. Diabetologia, 64, pp. 1963-1972. (doi: 10.1007/s00125-021-05484-6)

Burton, J. K., McMinn, M., Vaughan, J. E., Fleuriot, J., Guthrie, B. (2021) Care-home outbreaks of COVID-19 in Scotland March to May 2020: national linked data cohort analysis. Age and Ageing, 50, pp. 1482-1492. (doi: 10.1093/ageing/afab099)

Pellicori, P., Cleland, J. G.F. (2021) Structural heart disease, cardiac dysfunction and heart failure: the ambiguity of a definition. European Journal of Preventive Cardiology, 28, pp. 921-923. (doi: 10.1177/2047487320937135)

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Butt, J. H., Nicolau, J. C., Verma, S., Docherty, K. F., Petrie, M. C., Inzucchi, S. E., Schou, M., Kosiborod, M. N., Langkilde, A. M., Martinez, F. A., Ponikowski, P., Sabatine, M. S., Sjöstrand, M., Solomon, S. D., Bengtsson, O., Jhund, P. S., McMurray, J., Køber, L. (2021) Efficacy and safety of dapagliflozin according to aetiology in heart failure with reduced ejection fraction: insights from the DAPA-HF trial. European Journal of Heart Failure, 23, pp. 601-613. (doi: 10.1002/ejhf.2124)

Padmanabhan, S., Dominiczak, A. F. (2021) Genomics of hypertension: the road to precision medicine. Nature Reviews Cardiology, 18, pp. 235-250. (doi: 10.1038/s41569-020-00466-4)

Ferreira, J. P., Lam, C. S. P., Anker, S. D., Mehra, M. R., van Veldhuisen, D. J., Byra, W. M., La Police, D. A., Cleland, J. G.F., Greenberg, B., Zannad, F. (2021) Plasma D‐dimer concentrations predicting stroke risk and rivaroxaban benefit in patients with heart failure and sinus rhythm: an analysis from the COMMANDER‐HF trial. European Journal of Heart Failure, 23, pp. 648-656. (doi: 10.1002/ejhf.2003)

Ferreira, J. P. et al. (2021) Proteomic and mechanistic analysis of spironolactone in patients at risk for HF. JACC: Heart Failure, 9, pp. 268-277. (doi: 10.1016/j.jchf.2020.11.010)

Petermann-Rocha, F., Parra-Soto, S., Gray, S., Anderson, J., Welsh, P., Gill, J., Sattar, N., Ho, F. K., Celis-Morales, C., Pell, J. P. (2021) Vegetarians, fish, poultry and meat-eaters: who has higher risk of CVD incidence and mortality? A prospective study from UK Biobank. European Heart Journal, 42, pp. 1136-1143. (doi: 10.1093/eurheartj/ehaa939)

Uijl, A., Vaartjes, I., Denaxas, S., Hemingway, H., Shah, A. D., Cleland, J., Grobbee, D. E., Hoes, A. W., Asselbergs, F. W., Koudstaal, S. (2021) Temporal trends in heart failure medication prescription in a population-based cohort study. BMJ Open, 11, (doi: 10.1136/bmjopen-2020-043290)

Pellicori, P., Doolub, G., Wong, C. M., Lee, K. S., Mangion, K., Ahmad, M., Berry, C., Squire, I., Lambiase, P., Lyon, A. R., McConnachie, A., Taylor, R. S., Cleland, J. G.F. (2021) COVID-19 and its cardiovascular effects: a systematic review of prevalence studies. Cochrane Database of Systematic Reviews, 2021, (doi: 10.1002/14651858.CD013879)

Smart, N. A., Pearson, M. J., Taylor, R. S., Cleland, J. (2021) Exercise training for heart failure with preserved ejection fraction (ExTraMATCH III): protocol for an individual patient data meta-analysis. Journal of Clinical Exercise Physiology, 10, pp. 3-11. (doi: 10.31189/2165-7629-10.1.3)

Mordi, I. R., Ouwerkerk, W., Anker, S. D., Cleland, J. G., Dickstein, K., Metra, M., Ng, L. L., Samani, N. J., van Veldhuisen, D. J., Zannad, F., Voors, A. A., Lang, C. C. (2021) Heart failure treatment up-titration and outcome and age: an analysis of BIOSTAT-CHF. European Journal of Heart Failure, 23, pp. 436-444. (doi: 10.1002/ejhf.1799)

Ferreira, J. P., Cleland, J. G.F., Lam, C. S.P., van Veldhuisen, D., Byra, W. M., La Police, D. A., Anker, S. D., Mehra, M. R., Leroy, C., Eschwege, V., Toussaint-Hacquard, M., Rossignol, P., Greenberg, B., Zannad, F. (2021) Impact of geographic region on the COMMANDER-HF Trial. JACC: Heart Failure, 9, pp. 201-211. (doi: 10.1016/j.jchf.2020.11.007)

Quinn, T. J., Burton, J. K., Carter, B., Cooper, N., Dwan, K., Field, R., Freeman, S. C., Geue, C., Hsieh, P.-H., McGill, K., Nevill, C. R., Rana, D., Sutton, A., Taylor Rowan, M., Xin, Y. (2021) Following the Science? Comparison of methodological and reporting quality of covid-19 and other research from the first wave of the pandemic. BMC Medicine, 19, (doi: 10.1186/s12916-021-01920-x)

Irvine, L., Burton, J. K., Ali, M., Quinn, T. J., Goodman, C. (2021) Protocol for the development of a repository of individual participant data from randomised controlled trials conducted in adult care homes (The Virtual International Care Homes Trials Archive (VICHTA)) Trials, 22, (doi: 10.1186/s13063-021-05107-w)

Ehteshami-Afshar, S., Mooney, L., Dewan, P., Desai, A. S., Lang, N. N., Lefkowitz, M. P., Petrie, M. C., Rizkala, A. R., Rouleau, J. L., Solomon, S. D., Swedberg, K., Shi, V. C., Zile, M. R., Packer, M., McMurray, J. J.V., Jhund, P. S., Hawkins, N. M. (2021) Clinical characteristics and outcomes of patients with heart failure with reduced ejection fraction and chronic obstructive pulmonary disease: insights from PARADIGM-HF. Journal of the American Heart Association, 10, (doi: 10.1161/JAHA.120.019238)

Thom, G., McIntosh, A., Messow, C.-M., Leslie, W. S., Barnes, A. C., Brosnahan, N., McCombie, L., Malkova, D., Al-Mrabeh, A., Zhyzhneuskaya, S., Welsh, P., Sattar, N., Taylor, R., Lean, M. E.J. (2021) Weight loss induced increase in fasting ghrelin concentration is a predictor of weight regain: evidence from the Diabetes Remission Clinical Trial. Diabetes, Obesity and Metabolism, 23, pp. 711-719. (doi: 10.1111/dom.14274)

Lee, M. M.Y. et al. (2021) Effect of empagliflozin on left ventricular volumes in patients with type 2 diabetes, or prediabetes, and heart failure with reduced ejection fraction (SUGAR-DM-HF) Circulation, 143, pp. 516-525. (doi: 10.1161/CIRCULATIONAHA.120.052186)

Cleland, J. G.F. et al. (2021) The effect of spironolactone on cardiovascular function and markers of fibrosis in people at increased risk of developing heart failure: the heart 'OMics' in AGEing (HOMAGE) randomized clinical trial. European Heart Journal, 42, pp. 684-696. (doi: 10.1093/eurheartj/ehaa758)

Inzucchi, S. E., Docherty, K. F., Køber, L., Kosiborod, M. N., Martinez, F. A., Ponikowski, P., Sabatine, M. S., Solomon, S. D., Verma, S., Bělohlávek, J., Böhm, M., Chiang, C.-E., de Boer, R. A., Diez, M., Dukát, A., Ljungman, C. E.A., Bengtsson, O., Langkilde, A. M., Sjöstrand, M., Jhund, P. S., McMurray, J. J.V. (2021) Dapagliflozin and the incidence of type 2 diabetes in patients with heart failure and reduced ejection fraction: an exploratory analysis from DAPA-HF. Diabetes Care, 44, pp. 586-594. (doi: 10.2337/dc20-1675)

Maznyczka, A. M., McCartney, P., Duklas, P., McEntegart, M., Oldroyd, K., Greenwood, J., Muir, D., Chowdhary, S., Gershlick, A. H., Eteiba, H., Cotton, J., Wragg, A., Curzen, N., Tait, R., Macfarlane, P., Welsh, P., Sattar, N., Petrie, M., Ford, I., Fox, K., McConnachie, A., Berry, C. (2021) Effect of coronary flow on intracoronary alteplase: a prespecified analysis from a randomised trial. Heart, 107, pp. 299-312. (doi: 10.1136/heartjnl-2020-317828)

Felker, G. M. et al. (2021) Effects of a novel nitroxyl donor in acute heart failure: the STAND-UP AHF Study. JACC: Heart Failure, 9, pp. 146-157. (doi: 10.1016/j.jchf.2020.10.012)

Donin, A. S., Nightingale, C. M., Perkin, M. R., Ussher, M., Jebb, S. A., Landberg, R., Welsh, P., Sattar, N., Adab, P., Owen, C. G., Rudnicka, A. R., Cook, D. G., Whincup, P. H. (2021) Evaluating an intervention to increase cereal fiber intake in children: a randomized controlled feasibility trial. Journal of Nutrition, 151, pp. 379-386. (doi: 10.1093/jn/nxaa347)

Duncan Millar, J., van Wijck, F., Pollock, A., Ali, M. (2021) International consensus recommendations for outcome measurement in poststroke arm rehabilitation trials. European Journal of Physical and Rehabilitation Medicine, 57, pp. 61-68. (doi: 10.23736/S1973-9087.20.06575-2)

Halliday, B. P., Owen, R., Gregson, J., Vassiliou, V., Chen, X., Wage, R., Lota, A. S., Khalique, Z., Tayal, U., Hammersley, D. J., Jones, R. E., Baksi, A. J., Cowie, M. R., Cleland, J. G.F., Pennell, D. J., Prasad, S. K. (2021) Myocardial remodelling after withdrawing therapy for heart failure in patients with recovered dilated cardiomyopathy – insights from TRED‐HF. European Journal of Heart Failure, 23, pp. 293-301. (doi: 10.1002/ejhf.2063)

Docherty, K. F., Campbell, R. T., Brooksbank, K. J.M., Godeseth, R. L., Forsyth, P., McConnachie, A., Roditi, G., Stanley, B., Welsh, P., Jhund, P. S., Petrie, M. C., McMurray, J. J.V. (2021) Rationale and methods of a randomized trial evaluating the effect of neprilysin inhibition on left ventricular remodelling. ESC Heart Failure, 8, pp. 129-138. (doi: 10.1002/ehf2.13137)

Platz, E., Jhund, P. S. (2021) Risk stratification in patients presenting with acute heart failure. European Heart Journal: Acute Cardiovascular Care, 10, pp. 113-115. (doi: 10.1093/ehjacc/zuab005)

Al Ozairi, E., Alroudhan, D., Alsaeed, D., Voase, N., Hasan, A., Gill, J. M.R., Sattar, N., Welsh, P., Gray, C. M., Boonpor, J., Celis-Morales, C., Gray, S. R. (2021) Skeletal muscle and metabolic health – how do we increase muscle mass and function in people with type 2 diabetes. Journal of Clinical Endocrinology and Metabolism, 106, pp. 309-317. (doi: 10.1210/clinem/dgaa835)

Jhund, P. S. et al. (2021) Efficacy of dapagliflozin on renal function and outcomes in patients with heart failure with reduced ejection fraction: results of DAPA-HF. Circulation, 143, pp. 289-309. (doi: 10.1161/CIRCULATIONAHA.120.050391)

Samuel, N. A., Cuthbert, J. J., Brown, O. I., Kazmi, S., Cleland, J. G.F., Rigby, A. S., Clark, A. L. (2021) Relation between thyroid function and mortality in patients with chronic heart failure. American Journal of Cardiology, 139, pp. 57-63. (doi: 10.1016/j.amjcard.2020.10.034)

Teerlink, J. R. et al. (2021) Cardiac myosin activation with omecamtiv mecarbil in systolic heart failure. New England Journal of Medicine, 384, pp. 105-116. (doi: 10.1056/NEJMoa2025797)

Bekfani, T., Fudim, M., Cleland, J. G.F., Jorbenadze, A., Haehling, S., Lorber, A., Rothman, A. M.‐K., Stein, K., Abraham, W. T., Sievert, H., Anker, S. D. (2021) A current and future outlook on upcoming technologies in the remote monitoring of patients with heart failure. European Journal of Heart Failure, 23, pp. 175-185. (doi: 10.1002/ejhf.2033)

MacRae, C., Henderson, D. A.G., Mercer, S. W., Burton, J., De Sousa, N., Grill, P., Marwick, C., Guthrie, B. (2021) Excessive polypharmacy and potentially inappropriate prescribing in 147 care homes: a cross-sectional study. BJGP Open, 5, pp. BJGPO.2021.0167. (doi: 10.3399/BJGPO.2021.0167)

Davison, B. A., Senger, S., Sama, I. E., Koch, G. G., Mebazaa, A., Dickstein, K., Samani, N. J., Metra, M., Anker, S. D., Cleland, J. G., Ng, L. L., Mordi, I. R., Zannad, F., Filippatos, G. S., Hillege, H. L., Ponikowski, P., Veldhuisen, D. J., Lang, C. C., Meer, P., Núñez, J., Bayés‐Genís, A., Edwards, C., Voors, A. A., Cotter, G. (2021) Is acute heart failure a distinctive disorder? An analysis from BIOSTAT‐CHF. European Journal of Heart Failure, 23, pp. 43-57. (doi: 10.1002/ejhf.2077)

McCallum, L., Brooksbank, K., McConnachie, A., Aman, A., Lip, S., Dawson, J., MacIntyre, I. M., MacDonald, T. M., Webb, D. J., Padmanabhan, S. (2021) Rationale and design of the genotype-blinded trial of torasemide for the treatment of hypertension (BHF UMOD) American Journal of Hypertension, 34, pp. 92-99. (doi: 10.1093/ajh/hpaa166)

He, T., Melgarejo, J. D., Clark, A. L., Yu, Y.‐L., Thijs, L., Díez, J., López, B., González, A., Cleland, J. G., Schanstra, J. P., Vlahou, A., Latosinska, A., Mischak, H., Staessen, J. A., Zhang, Z.‐Y., Jankowski, V. (2021) Serum and urinary biomarkers of collagen type‐I turnover predict prognosis in patients with heart failure. Clinical and Translational Medicine, 11, (doi: 10.1002/ctm2.267)

Grill, P., Marwick, C., De Souza, N., Burton, J. K., Hughes, C., Guthrie, B. (2021) The burden of psychotropic and anticholinergic medicines use in care homes: population-based analysis in 147 care homes. Age and Ageing, 50, pp. 183-189. (doi: 10.1093/ageing/afaa122)

Anderson, J. J., Welsh, P., Ho, F. K., Ferguson, L. D., Welsh, C. E., Pellicori, P., Cleland, J. G.F., Forbes, J., Iliodromiti, S., Boyle, J., Lindsay, R., Celis-Morales, C., Gray, S. R., Katikireddi, S. V., Gill, J. M. R., Pell, J. P., Sattar, N. (2021) Ethnic differences in prevalence of actionable HbA1c levels in UK Biobank: implications for screening. BMJ Open Diabetes Research and Care, 9, (doi: 10.1136/bmjdrc-2021-002176)

Farina, N., Suemoto, C. K., Burton, J. K., Oliveira, D., Frost, R. (2021) Perceptions of dementia amongst the general public across Latin America: a systematic review. Aging and Mental Health, 25, pp. 787-796. (doi: 10.1080/13607863.2020.1725738)

Wijkman, M. O., Malachias, M. V.B., Claggett, B. L., Cheng, S., Matsushita, K., Shah, A. M., Jhund, P. S., Coresh, J., Solomon, S. D., Vardeny, O. (2021) Resistance to antihypertensive treatment and long-term risk: The Atherosclerosis Risk in Communities study. Journal of Clinical Hypertension, 23, pp. 1887-1896. (doi: 10.1111/jch.14269)

Shoaib, A., Van Spall, H. G.C., Wu, J., Cleland, J. G.F., McDonagh, T. A., Rashid, M., Mohamed, M. O., Ahmed, F. Z., Deanfield, J., de Belder, M., Gale, C. P., Mamas, M. A. (2021) Substantial decline in hospital admissions for heart failure accompanied by increased community mortality during COVID-19 pandemic. European Heart Journal: Quality of Care and Clinical Outcomes, 7, pp. 378-387. (doi: 10.1093/ehjqcco/qcab040)

2020

Brown, R., Welsh, P., Logue, J. (2020) Systematic review of clinical guidelines for lipid-lowering in the secondary prevention of cardiovascular disease events. Open Heart, 7, (doi: 10.1136/openhrt-2020-001396)

Goncalves Soares, A., Kilpi, F., Fraser, A., Nelson, S. M., Sattar, N., Welsh, P. I., Tilling, K., Lawlor, D. A. (2020) Longitudinal changes in reproductive hormones through the menopause transition in the Avon Longitudinal Study of Parents and Children (ALSPAC) Scientific Reports, 10, (doi: 10.1038/s41598-020-77871-9)

Purcell, C., Daw, P., Kerr, C., Cleland, J., Cowie, A., Dalal, H., Ibbotson, T., Murphy, C., Taylor, R. (2020) Protocol for an implementation study of an evidence-based home cardiac rehabilitation programme for people with heart failure and their caregivers in Scotland (SCOT:REACH-HF) BMJ Open, 10, (doi: 10.1136/bmjopen-2020-040771)

Ferguson, A. C., Tank, R., Lyall, L. M., Ward, J., Welsh, P., Celis-Morales, C., McQueenie, R., Strawbridge, R. J., Mackay, D. F., Pell, J. P., Smith, D. J., Sattar, N., Cavanagh, J., Lyall, D. M. (2020) Association of SBP and BMI with cognitive and structural brain phenotypes in UK Biobank. Journal of Hypertension, 38, pp. 2482-2489. (doi: 10.1097/HJH.0000000000002579)

Surendran, P. et al. (2020) Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals. Nature Genetics, 52, pp. 1314-1332. (doi: 10.1038/s41588-020-00713-x)

Felker, G. M., Solomon, S. D., McMurray, J. J.V., Cleland, J. G.F., Abbasi, S. A., Malik, F. I., Zhang, H., Globe, G., Teerlink, J. R. (2020) Effects of omecamtiv mecarbil on symptoms and health-related quality of life in patients with chronic heart failure: results from the COSMIC-HF study. Circulation: Heart Failure, 13, (doi: 10.1161/CIRCHEARTFAILURE.120.007814)

Ferreira, J. P., Docherty, K. F., Stienen, S., Jhund, P. S., Claggett, B. L., Solomon, S. D., Petrie, M. C., Gregsone, J., Pocock, S. L., Zannad, F., McMurray, J. (2020) Estimating the lifetime benefits of treatments for heart failure. JACC: Heart Failure, 8, pp. 984-995. (doi: 10.1016/j.jchf.2020.08.004)

Kristensen, S. L., Castagno, D., Shen, L., Jhund, P., Docherty, K., Rørth, R., Abraham, W. T., Desai, A., Dickstein, K., Rouleau, J. L., Zile, M. R., Swedberg, K., Packer, M., Solomon, S. D., Køber, L., McMurray, J. J.V. (2020) Prevalence and incidence of intra-ventricular conduction delays and outcomes in patients with heart failure and reduced ejection fraction: insights from PARADIGM‐HF and ATMOSPHERE. European Journal of Heart Failure, 22, pp. 2370-2379. (doi: 10.1002/ejhf.1972)

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Mackenzie, I. S. et al. (2020) Long-term cardiovascular safety of febuxostat compared with allopurinol in patients with gout (FAST): a multicentre, prospective, randomised, open-label, non-inferiority trial. Lancet, 396, pp. 1745-1757. (doi: 10.1016/S0140-6736(20)32234-0)

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Ho, F. K., Celis-Morales, C. A., Gray, S. R., Katikireddi, S. V., Niedzwiedz, C. L., Hastie, C., Ferguson, L. D., Berry, C., Mackay, D. F., Gill, J. M.R., Pell, J. P., Sattar, N., Welsh, P. (2020) Modifiable and non-modifiable risk factors for COVID-19, and comparison to risk factors for influenza and pneumonia: results from a UK Biobank prospective cohort study. BMJ Open, 10, (doi: 10.1136/bmjopen-2020-040402)

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Musa, M. K., Akdur, G., Hanratty, B., Kelly, S., Gordon, A., Peryer, G., Spilsbury, K., Killett, A., Burton, J., Meyer, J., Fortescue, S., Towers, A.-M., Irvine, L., Goodman, C. (2020) Uptake and use of a minimum data set (MDS) for older people living and dying in care homes in England: a realist review protocol. BMJ Open, 10, (doi: 10.1136/bmjopen-2020-040397)

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Quint, J. K., Rajagopalan, S., Cleland, J. G.F., Simon, D. I., Banerjee, A., Briere, J.-B., Bowrin, K., Cohen, A., Halcox, J., Zakeri, R., Bloom, C., Sundaram, V. (2020) Temporal trends in the incidence, treatment patterns, and outcomes of coronary artery disease and peripheral artery disease in the UK, 2006–2015. European Heart Journal, 41, pp. 1636-1649. (doi: 10.1093/eurheartj/ehz880)

Anderson, J. J., Gray, S. R., Welsh, P., Mackay, D. F., Celis-Morales, C. A., Lyall, D. M., Forbes, J., Sattar, N., Gill, J. M.R., Pell, J. P. (2020) The associations of sugar-sweetened, artificially sweetened and naturally sweet juices with all-cause mortality in 198,285 UK Biobank participants: a prospective cohort study. BMC Medicine, 18, (doi: 10.1186/s12916-020-01554-5)

Siedlinski, M., Jozefczuk, E., Xu, X., Teumer, A., Evangelou, E., Schnabel, R. B., Welsh, P., Maffia, P., Erdmann, J., Tomaszewski, M., Caulfield, M. J., Sattar, N., Holmes, M. V., Guzik, T. J. (2020) White blood cells and blood pressure: a Mendelian randomization study. Circulation, 141, pp. 1307-1317. (doi: 10.1161/CIRCULATIONAHA.119.045102)

Petrie, M. C., et al. (2020) Effect of dapagliflozin on worsening heart failure and cardiovascular death in patients with heart failure with and without diabetes. JAMA: Journal of the American Medical Association, 323, pp. 1353-1368. (doi: 10.1001/jama.2020.1906)

White, S. L., Begum, S., Vieira, M. C., Seed, P., Lawlor, D. L., Sattar, N., Nelson, S. M., Welsh, P., Pasupathy, D., Poston, L., on behalf of UPBEAT Consortium, (2020) Metabolic phenotyping by treatment modality in obese women with gestational diabetes suggests diverse pathophysiology: An exploratory study. PLoS ONE, 15, (doi: 10.1371/journal.pone.0230658)

Pandhi, P., Maaten, J. M., Emmens, J. E., Struck, J., Bergmann, A., Cleland, J. G., Givertz, M. M., Metra, M., O'Connor, C. M., Teerlink, J. R., Ponikowski, P., Cotter, G., Davison, B., Veldhuisen, D. J., Voors, A. A. (2020) Clinical value of pre‐discharge bio‐adrenomedullin as a marker of residual congestion and high risk of heart failure hospital readmission. European Journal of Heart Failure, 22, pp. 683-691. (doi: 10.1002/ejhf.1693)

Wigmore, E. M., Hafferty, J. D., Hall, L. S., Howard, D. M., Clarke, T.-K., Fabbri, C., Lewis, C. M., Uher, R., Navrady, L. B., Adams, M. J., Zeng, Y., Campbell, A., Gibson, J., Thomson, P. A., Hayward, C., Smith, B. H., Hocking, L. J., Padmanabhan, S., Deary, I. J., Porteous, D. J., Mors, O., Mattheisen, M., Nicodemus, K. K., McIntosh, A. M. (2020) Genome-wide association study of antidepressant treatment resistance in a population-based cohort using health service prescription data and meta-analysis with GENDEP. Pharmacogenomics Journal, 20, pp. 329-341. (doi: 10.1038/s41397-019-0067-3)

Jackson, A. M., Zhang, R., Findlay, I., Robertson, K., Lindsay, M., Morris, T., Forbes, B., Papworth, R., McConnachie, A., Mangion, K., Jhund, P. S., McCowan, C., Berry, C. (2020) Healthcare disparities for women hospitalised with myocardial infarction and angina. European Heart Journal: Quality of Care and Clinical Outcomes, 6, pp. 156-165. (doi: 10.1093/ehjqcco/qcz040)

Simpson, J., Jhund, P. S., Lund, L. H., Padmanabhan, S., Clagget, B. L., Shen, L., Petrie, M. C., Abraham, W. T., Desai, A. S., Dickstein, K., Kober, L., Paker, M., Rouleau, J. L., Mueller-Velten, G., Solomon, S. D., Swedberg, K., Zile, M. R., McMurray, J. J.V. (2020) Prognostic models derived in PARADIGM-HF and validated in ATMOSPHERE and the Swedish Heart Failure Registry to predict mortality and morbidity in chronic heart failure. JAMA Cardiology, 5, pp. 432-441. (doi: 10.1001/jamacardio.2019.5850)

Wehner, G. J., Jing, L., Haggerty, C. M., Suever, J. D., Leader, J. B., Hartzel, D. N., Kirchner, H. L., Manus, J. N.A., James, N., Ayar, Z., Gladding, P., Good, C. W., Cleland, J. G.F., Fornwalt, B. K. (2020) Routinely reported ejection fraction and mortality in clinical practice: where does the nadir of risk lie? European Heart Journal, 41, pp. 1249-1257. (doi: 10.1093/eurheartj/ehz550)

Cleland, J. G.F., Lyon, A. R., McDonagh, T., McMurray, J. J.V. (2020) The year in cardiology: heart failure. European Heart Journal, 41, pp. 1232-1248. (doi: 10.1093/eurheartj/ehz949)

Welsh, C., Celis-Morales, C. A., Ho, F., Lyall, D. M., Mackay, D., Ferguson, L., Sattar, N., Gray, S. R., Gill, J. M.R., Pell, J. P., Welsh, P. (2020) Association of injury related hospital admissions with commuting by bicycle in the UK: prospective population based study. British Medical Journal, 368, (doi: 10.1136/bmj.m336)

Ho, F. K., Gray, S. R., Welsh, P., Petermann-Rocha, F., Foster, H., Waddell, H., Anderson, J., Lyall, D., Sattar, N., Gill, J. M.R., Mathers, J. C., Pell, J. P., Celis-Morales, C. (2020) Associations of fat and carbohydrate intake with cardiovascular disease and mortality: prospective cohort study of UK Biobank participants. British Medical Journal, 368, (doi: 10.1136/bmj.m688)

Shen, L., Jhund, P., McMurray, J. (2020) Dyslipidaemia, a factor worthy of adjustment: reply. European Journal of Heart Failure, 22, pp. 564-565. (doi: 10.1002/ejhf.1718)

Tromp, J., Bamadhaj, S., Cleland, J. G.F., Angermann, C. E., Dahlstrom, U., Ouwerkerk, W., Tay, W. T., Dickstein, K., Ertl, G., Hassanein, M., Hu, D., Perrone, S. V., Ghadanfar, M., Schweizer, A., Obergfell, A., Lam, C. S.P., Filippatos, G., Collins, S. P. (2020) Post-discharge prognosis of patients admitted to hospital for heart failure by world region, and national level of income and income disparity (REPORT-HF): a cohort study. Lancet Global Health, 8, pp. e411-e422. (doi: 10.1016/S2214-109X(20)30004-8)

Docherty, K. F., Shen, L., Castagno, D., Petrie, M. C., Abraham, W. T., Böhm, M., Desai, A. S., Dickstein, K., Køber, L. V., Packer, M., Rouleau, J. L., Solomon, S. D., Swedberg, K., Vazir, A., Zile, M. R., Jhund, P. S., McMurray, J. J.V. (2020) Relationship between heart rate and outcomes in patients in sinus rhythm or atrial fibrillation with heart failure and reduced ejection fraction. European Journal of Heart Failure, 22, pp. 528-538. (doi: 10.1002/ejhf.1682)

Santema, B. T., Chan, M. M.Y., Tromp, J., Dokter, M., van der Wal, H. H., Emmens, J. E., Takens, J., Samani, N. J., Ng, L. L., Lang, C. C., van der Meer, P., ter Maaten, J. M., Damman, K., Dickstein, K., Cleland, J. G., Zannad, F., Anker, S. D., Metra, M., van der Harst, P., de Boer, R. A., van Veldhuisen, D. J., Rienstra, M., Lam, C. S.P., Voors, A. A. (2020) The influence of atrial fibrillation on the levels of NT-proBNP versus GDF-15 in patients with heart failure. Clinical Research in Cardiology, 109, pp. 331-338. (doi: 10.1007/s00392-019-01513-y)

Serenelli, M., Jackson, A., Dewan, P., Jhund, P. S., Petrie, M. C., Rossignol, P., Campo, G., Pitt, B., Zannad, F., Ferreira, J. P., McMurray, J. J.V. (2020) Mineralocorticoid receptor antagonists, blood pressure, and outcomes in heart failure with reduced ejection fraction. JACC: Heart Failure, 8, pp. 188-198. (doi: 10.1016/j.jchf.2019.09.011)

Rorth, R., Jhund, P. S., Yilmaz, M. B., Kristensen, S. L., Welsh, P., Desai, A. S., Køber, L., Prescott, M. F., Rouleau, J. L., Solomon, S. D., Swedberg, K., Zile, M. R., Packer, M., McMurray, J. J.V. (2020) Comparison of BNP and NT-proBNP in patients with heart failure and reduced ejection fraction. Circulation: Heart Failure, 13, (doi: 10.1161/CIRCHEARTFAILURE.119.006541)

McMurray, J. J.V. et al. (2020) Effects of Sacubitril-Valsartan, versus Valsartan, in Women Compared to Men with Heart Failure and Preserved Ejection Fraction: Insights from PARAGON-HF. Circulation, 141, pp. 338-351. (doi: 10.1161/CIRCULATIONAHA.119.044491)

Maznyczka, A. M., McCartney, P. J., Oldroyd, K. G., Lindsay, M., McEntegart, M., Eteiba, H., Rocchiccioli, P., Good, R., Shaukat, A., Robertson, K., Kodoth, V., Greenwood, J. P., Cotton, J. M., Hood, S., Watkins, S., Macfarlane, P. W., Kennedy, J., Tait, C., Welsh, P., Sattar, N., Collison, D., Gillespie, L., McConnachie, A., Berry, C. (2020) Effects of intracoronary alteplase on microvascular function in acute myocardial infarction. Journal of the American Heart Association, 9, (doi: 10.1161/JAHA.119.014066)

Cameron, A. C., Welsh, P., Neves, K. B., Newby, D., Touyz, R. M., Lang, N. (2020) Acute vascular effects of vascular endothelial growth factor inhibition in the forearm arterial circulation. Journal of Hypertension, 38, pp. 257-265. (doi: 10.1097/HJH.0000000000002230)

Seferović, P. M. et al. (2020) European Society of Cardiology/Heart Failure Association position paper on the role and safety of new glucose‐lowering drugs in patients with heart failure. European Journal of Heart Failure, 22, pp. 196-213. (doi: 10.1002/ejhf.1673)

Bégué, C., Mörner, S., Brito, D., Hengstenberg, C., Cleland, J. G.F., Arbustini, E., Galve, E., Wichter, T., Richter, A., Golmard, J.-L., Bernard, M., Dubourg, O., Komajda, M., Charron, P., Isnard, R. (2020) Mid-regional proatrial natriuretic peptide for predicting prognosis in hypertrophic cardiomyopathy. Heart, 106, pp. 196-202. (doi: 10.1136/heartjnl-2019-314826)

Jhund, P. S. (2020) The recurring problem of heart failure hospitalisations. European Journal of Heart Failure, 22, pp. 249-250. (doi: 10.1002/ejhf.1721)

Welsh, C., Welsh, P., Celis Morales, C. A., Mark, P., Mackay, D., Ghouri, N., Ho, F., Ferguson, L. D., Brown, R., Lewsey, J., Cleland, J. G., Gray, S. R., Lyall, D. M., Anderson, J., Jhund, P. S., Pell, J., McGuire, D. K., Gill, J. M.R., Sattar, N. (2020) Glycated hemoglobin, prediabetes and the links to cardiovascular disease: data from UK Biobank. Diabetes Care, 43, pp. 440-445. (doi: 10.2337/dc19-1683)

Kosiborod, M. N., Jhund, P., Docherty, K. F., Diez, M., Petrie, M. C., Verma, S., Nicolau, J. C., Merkely, B., Kitakaze, M., DeMets, D. L., Inzucchi, S. E., Køeber, L., Martinez, F. A., Ponikowski, P., Sabatine, M. S., Solomon, S. D., Bengtsson, O., Lindholm, D., Niklasson, A., Sjöstrand, M., Langkilde, A. M., McMurray, J. J.V. (2020) Effects of dapagliflozin on symptoms, function and quality of life in patients with heart failure and reduced ejection fraction: results from the DAPA-HF trial. Circulation, 141, pp. 90-99. (doi: 10.1161/CIRCULATIONAHA.119.044138)

Martinez, F. A., Serenelli, M., Nicolau, J. C., Petrie, M. C., Chiang, C.-E., Tereshchenko, S., Solomon, S. D., Inzucchi, S. E., Køber, L., Kosiborod, M. N., Ponikowski, P., Sabatine, M. S., DeMets, D. L., Dutkiewicz-Piasecka, M., Bengtsson, O., Sjöstrand, M., Langkilde, A. M., Jhund, P., McMurray, J. J.V. (2020) Efficacy and safety of dapagliflozin in heart failure with reduced ejection fraction according to age: insights from DAPA-HF. Circulation, 141, pp. 100-111. (doi: 10.1161/CIRCULATIONAHA.119.044133)

Filippatos, G., Angermann, C. E., Cleland, J. G.F., Lam, C. S.P., Dahlström, U., Dickstein, K., Ertl, G., Hassanein, M., Hart, K. W., Lindsell, C. J., Perrone, S. V., Guerin, T., Ghadanfar, M., Schweizer, A., Obergfell, A., Collins, S. P. (2020) Global differences in characteristics, precipitants, and initial management of patients presenting with acute heart failure. JAMA Cardiology, 5, pp. 401-410. (doi: 10.1001/jamacardio.2019.5108)

Ferreira, J. P., Ouwerkerk, W., Tromp, J., Ng, L., Dickstein, K., Anker, S., Filippatos, G., Cleland, J. G., Metra, M., van Veldhuisen, D. J., Voors, A. A., Zannad, F. (2020) Cardiovascular and non‐cardiovascular death distinction: the utility of troponin beyond N‐terminal pro‐B‐type natriuretic peptide. Findings from the BIOSTAT‐CHF study. European Journal of Heart Failure, 22, pp. 81-89. (doi: 10.1002/ejhf.1654)

Pellicori, P., Cleland, J. G.F., Clark, A. L. (2020) Chronic obstructive pulmonary disease and heart failure: a breathless conspiracy. Heart Failure Clinics, 16, pp. 33-44. (doi: 10.1016/j.hfc.2019.08.003)

Nikolaidou, T., Samuel, N. A., Marincowitz, C., Fox, D. J., Cleland, J. G.F., Clark, A. L. (2020) Electrocardiographic characteristics in patients with heart failure and normal ejection fraction: a systematic review and meta‐analysis. Annals of Noninvasive Electrocardiology, 25, (doi: 10.1111/anec.12710)

Kobayashi, M., Voors, A. A., Girerd, N., Billotte, M., Anker, S. D., Cleland, J. G., Lang, C. C., Ng, L. L., van Veldhuisen, D. J., Dickstein, K., Metra, M., Duarte, K., Rossignol, P., Zannad, F., Ferreira, J. P. (2020) Heart failure etiologies and clinical factors precipitating for worsening heart failure: Findings from BIOSTAT-CHF. European Journal of Internal Medicine, 71, pp. 62-69. (doi: 10.1016/j.ejim.2019.10.017)

Pellicori, P., Zhang, J., Cuthbert, J., Urbinati, A., Shah, P., Kazmi, S., Clark, A. L., Cleland, J. G.F. (2020) High sensitivity C-reactive protein in chronic heart failure: patient characteristics, phenotypes, and mode of death. Cardiovascular Research, 116, pp. 91-100. (doi: 10.1093/cvr/cvz198)

Pellicori, P., Khan, M. J. I., Graham, F. J., Cleland, J. G.F. (2020) New perspectives and future directions in the treatment of heart failure. Heart Failure Reviews, 25, pp. 147-159. (doi: 10.1007/s10741-019-09829-7)

Cao, T. H., Jones, D. J.L., Voors, A. A., Quinn, P. A., Sandhu, J. K., Chan, D. C.S., Parry, H. M., Mohan, M., Mordi, I. R., Sama, I. E., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., Hillege, H. L., Metra, M., Ponikowski, P., Samani, N. J., Van Veldhuisen, D. J., Zannad, F., Lang, C. C., Ng, L. L. (2020) Plasma proteomic approach in patients with heart failure: insights into pathogenesis of disease progression and potential novel treatment targets. European Journal of Heart Failure, 22, pp. 70-80. (doi: 10.1002/ejhf.1608)

Kao, D., Purohit, S., Jhund, P. (2020) Therapeutic futility and phenotypic heterogeneity in heart failure with preserved ejection fraction: what is the role of bionic learning? European Journal of Heart Failure, 22, pp. 159-161. (doi: 10.1002/ejhf.1658)

Anker, M. S., Hülsmann, M., Cleland, J. G. (2020) What do patients with heart failure die from? A single assassin or a conspiracy? European Journal of Heart Failure, 22, pp. 26-28. (doi: 10.1002/ejhf.1689)

Coll, A. P. et al. (2020) GDF15 mediates the effects of metformin on body weight and energy balance. Nature, 578, pp. 444-448. (doi: 10.1038/s41586-019-1911-y)

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2019

Kotecha, D., Gill, S. K., Flather, M. D., Holmes, J., Packer, M., Rosano, G., Böhm, M., McMurray, J. J.V., Wikstrand, J., Anker, S. D., van Veldhuisen, D. J., Manzano, L., von Lueder, T. G., Rigby, A. S., Andersson, B., Kjekshus, J., Wedel, H., Ruschitzka, F., Cleland, J. G.F., Damman, K., Redon, J., Coats, A. J.S. (2019) Impact of renal impairment on beta-blocker efficacy in patients with heart failure. Journal of the American College of Cardiology, 74, pp. 2893-2904. (doi: 10.1016/j.jacc.2019.09.059)

Dewan, P., Rorth, R., Raparelli, V., Campbell, R. T., Shen, L., Jhund, P. S., Petrie, M. C., Anand, I. S., Carson, P. E., Desai, A. S., Granger, C. B., Køber, L., Komajda, M., McKelvie, R. S., O'Meara, E., Pfeffer, M. A., Pitt, B., Solomon, S. D., Swedberg, K., Zile, M. R., McMurray, J. J.V. (2019) Sex-related differences in heart failure with preserved ejection fraction. Circulation: Heart Failure, 12, (doi: 10.1161/CIRCHEARTFAILURE.119.006539)

Teumer, A. et al. (2019) KCND3 potassium channel gene variant confers susceptibility to electrocardiographic early repolarization pattern. JCI Insight, 4, (doi: 10.1172/jci.insight.131156)

Ferguson, L. D., Brown, R., Celis-Morales, C., Welsh, P., Lyall, D. M., Pell, J. P., McInnes, I. B., Siebert, S., Sattar, N. (2019) Association of central adiposity with psoriasis, psoriatic arthritis and rheumatoid arthritis: a cross-sectional study of the UK Biobank. Rheumatology, 58, pp. 2137-2142. (doi: 10.1093/rheumatology/kez192)

Eastwood, S. V., Chaturvedi, N., Sattar, N., Welsh, P. I., Hughes, A. D., Tillin, T. (2019) Impact of kidney function on cardiovascular risk and mortality: a comparison of South Asian and European cohorts. American Journal of Nephrology, 50, pp. 425-433. (doi: 10.1159/000503873)

Johnson, M. J., Cockayne, S., Currow, D. C., Bell, K., Hicks, K., Fairhurst, C., Gabe, R., Torgerson, D., Jefferson, L., Oxberry, S., Ghosh, J., Hogg, K. J., Murphy, J., Allgar, V., Cleland, J. G.F., Clark, A. L. (2019) Oral modified release morphine for breathlessness in chronic heart failure: a randomised placebo-controlled trial. ESC Heart Failure, 6, pp. 1149-1160. (doi: 10.1002/ehf2.12498)

Jackson, A. M., Jhund, P. S. (2019) The price of a failing heart. European Journal of Heart Failure, 21, pp. 1532-1533. (doi: 10.1002/ejhf.1605)

Mehra, M. R., Vaduganathan, M., Fu, M., Ferreira, J. P., Anker, S. A., Cleland, J. G.F., Lam, C. S.P., van Veldhuisen, D. J., Byra, W. M., Spiro, T., Deng, H., Zannad, F., Greenberg, B. (2019) A comprehensive analysis of the effects of rivaroxaban on stroke or transient ischaemic attack in patients with heart failure, coronary artery disease, and sinus rhythm: the COMMANDER HF trial. European Heart Journal, 40, pp. 3593-3602. (doi: 10.1093/eurheartj/ehz427)

McMurray, J. J.V. et al. (2019) Dapagliflozin in patients with heart failure and reduced ejection fraction. New England Journal of Medicine, 381, pp. 1995-2008. (doi: 10.1056/NEJMoa1911303)

Tillin, T., Tuson, C., Sowa, B., Chattopadhyay, K., Sattar, N., Welsh, P., Roberts, I., Ebrahim, S., Kinra, S., Hughes, A., Chaturvedi, N. (2019) Yoga and Cardiovascular Health Trial (YACHT): a UK-based randomised mechanistic study of a yoga intervention plus usual care versus usual care alone following an acute coronary event. BMJ Open, 9, (doi: 10.1136/bmjopen-2019-030119)

Sillars, A., Celis-Morales, C. A., Ho, F., Petermann, F., Welsh, P., Iliodromiti, S., Ferguson, L. D., Lyall, D. M., Anderson, J., Mackay, D., Pellicori, P., Cleland, J., Pell, J. P., Gill, J. M.R., Gray, S. R., Sattar, N. (2019) Association of fitness and grip-strength with heart failure: findings from the UK Biobank population-based study. Mayo Clinic Proceedings, 94, pp. 2230-2240. (doi: 10.1016/j.mayocp.2019.04.041)

Steell, L., Ho, F. K., Sillars, A., Petermann, F., Li, H., Lyall, D. M., Iliodromiti, S., Welsh, P., Anderson, J., Mackay, D. F., Pell, J. P., Sattar, N., Gill, J. M.R., Gray, S. R., Celis-Morales, C. A. (2019) Dose-response associations of cardiorespiratory fitness with all-cause mortality and incidence and mortality of cancer and cardiovascular and respiratory diseases: the UK Biobank cohort study. British Journal of Sports Medicine, 53, pp. 1371-1378. (doi: 10.1136/bjsports-2018-099093)

Ferguson, L., Welsh, P., Brown, R., Tindell, A., Kerrigan, S., Sattar, N., McInnes, I., Siebert, S. (2019) Effect of Phosphodiesterase 4 Inhibition with Apremilast on Cardiometabolic Outcomes in Psoriatic Arthritis – Initial Results from the Immune Metabolic Associations in Psoriatic Arthritis (IMAPA) Study.

Lees, J. S., Welsh, C. E., Celis-Morales, C. A., Mackay, D., Lewsey, J., Gray, S. R., Lyall, D. M., Cleland, J. G., Gill, J. M.R., Jhund, P. S., Pell, J., Sattar, N., Welsh, P., Mark, P. B. (2019) Glomerular filtration rate by differing measures, albuminuria and prediction of cardiovascular disease, mortality and end-stage kidney disease. Nature Medicine, 25, pp. 1753-1760. (doi: 10.1038/s41591-019-0627-8)

Beusekamp, J. C., Tromp, J., Cleland, J. G.F., Givertz, M. M., Metra, M., O’Connor, C. M., Teerlink, J. R., Ponikowski, P., Ouwerkerk, W., van Veldhuisen, D. J., Voors, A. A., van der Meer, P. (2019) Hyperkalemia and treatment with RAAS inhibitors during acute heart failure hospitalizations and their association with mortality. JACC: Heart Failure, 7, pp. 970-979. (doi: 10.1016/j.jchf.2019.07.010)

Pellicori, P., Urbinati, A., Kaur, K., Zhang, J., Shah, P., Kazmi, S., Capucci, A., Cleland, J. G.F., Clark, A. L. (2019) Prevalence and incidence of atrial fibrillation in ambulatory patients with heart failure. American Journal of Cardiology, 124, pp. 1554-1560. (doi: 10.1016/j.amjcard.2019.08.018)

Conrad, N., Judge, A., Canoy, D., Tran, J., Pinho-Gomes, A. C., Millett, E. R.C., Salimi-Khorshidi, G., Cleland, J. G., McMurray, J. J.V., Rahimi, K. (2019) Temporal trends and patterns in mortality after incident heart failure: a longitudinal analysis of 86 000 individuals. JAMA Cardiology, 4, pp. 1102-1111. (doi: 10.1001/jamacardio.2019.3593)

Beldhuis, I. E., Streng, K. W., van der Meer, P., Ter Maaten, J. M., O'Connor, C. M., Metra, M., Dittrich, H. C., Ponikowski, P., Cotter, G., Cleland, J. G.F., Davison, B. A., Givertz, M. M., Teerlink, J. R., Bloomfield, D. M., Voors, A. A., Damman, K. (2019) Trajectories of changes in renal function in patients with acute heart failure. Journal of Cardiac Failure, 25, pp. 866-874. (doi: 10.1016/j.cardfail.2019.07.004)

Clark, D. W. et al. (2019) Associations of autozygosity with a broad range of human phenotypes. Nature Communications, 10, (doi: 10.1038/s41467-019-12283-6)

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2018

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Abuosa, A. M., Elshiekh, A. H., Qureshi, K., Abrar, M. B., Kholeif, M. A., Kinsara, A. J., Andejani, A., Ahmed, A. H., Cleland, J. G.F. (2018) Prophylactic use of carvedilol to prevent ventricular dysfunction in patients with cancer treated with doxorubicin. Indian Heart Journal, 70, pp. S96-S100. (doi: 10.1016/j.ihj.2018.06.011)

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Cao, T. H., Jones, D. J. L., Quinn, P. A., Chan, D. C. S., Hafid, N., Parry, H. M., Mohan, M., Sandhu, J. K., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., Hillege, H. L., Metra, M., Ponikowski, P., Samani, N. J., Van Veldhuisen, D. J., Zannad, F., Zwinderman, A. H., Voors, A. A., Lang, C. C., Ng, L. L. (2018) Using matrix assisted laser desorption ionisation mass spectrometry (MALDI-MS) profiling in order to predict clinical outcomes of patients with heart failure. Clinical Proteomics, 15, (doi: 10.1186/s12014-018-9213-1)

Celis-Morales, C.A., Petermann, F., Steell, L., Anderson, J., Welsh, P., Mackay, D.F., Iliodromiti, S., Lyall, D.M., Lean, M.E., Pell, J.P., Sattar, N., Gill, J.M.R., Gray, S.R. (2018) Associations of dietary protein intake with fat free mass and grip strength: cross-sectional study in 146,816 UK Biobank participants. American Journal of Epidemiology, 187, pp. 2405-2414. (doi: 10.1093/aje/kwy134)

Welsh, P., Preiss, D., Shah, A. S.V., McAllister, D., Briggs, A., Boachie, C., McConnachie, A., Hayward, C., Padmanabhan, S., Welsh, C., Woodward, M., Campbell, A., Porteous, D., Mills, N. L., Sattar, N. (2018) Comparison between high-sensitivity cardiac troponin T and cardiac troponin I in a large general population cohort. Clinical Chemistry, 64, pp. 1607-1616. (doi: 10.1373/clinchem.2018.292086)

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Sliz, E. et al. (2018) Metabolomic consequences of genetic inhibition of PCSK9 compared with statin treatment. Circulation, 138, pp. 2499-2512. (doi: 10.1161/CIRCULATIONAHA.118.034942)

Kristensen, S. L., Rørth, R., Jhund, P. S., Shen, L., Lee, M. M.Y., Petrie, M. C., Køber, L., McMurray, J. J.V. (2018) Microvascular complications in diabetes patients with heart failure and reduced ejection fraction-insights from the Beta-blocker Evaluation of Survival Trial. European Journal of Heart Failure, 20, pp. 1549-1556. (doi: 10.1002/ejhf.1201)

Narang, R., Saxena, A., Desai, A., Ramakrishnan, S., Thangjam, R. S., Kulkarni, S., Narvencar, K., Jacques' e Costa, A. K., Dias, A., Sukharamwala, R., Cleland, J. (2018) Prevalence and determinants of hypertension in apparently healthy schoolchildren in India: a multi-center study. European Journal of Preventive Cardiology, 25, pp. 1775-1784. (doi: 10.1177/2047487318790056)

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Zannad, F., Anker, S. D., Byra, W. M., Cleland, J. G.F., Fu, M., Gheorghiade, M., Lam, C. S.P., Mehra, M. R., Neaton, J. D., Nessel, C. C., Spiro, T. E., van Veldhuisen, D. J., Greenberg, B. (2018) Rivaroxaban in patients with heart failure, sinus rhythm, and coronary disease. New England Journal of Medicine, 379, pp. 1332-1342. (doi: 10.1056/NEJMoa1808848)

Rush, C. J., Campbell, R. T., Jhund, P. S., Petrie, M. C., McMurray, J. J.V. (2018) Association is not causation: treatment effects cannot be estimated from observational data in heart failure. European Heart Journal, 39, pp. 3417-3438. (doi: 10.1093/eurheartj/ehy407)

Mukhtar, O., Cheriyan, J., Cockcroft, J. R., Collier, D., Coulson, J. M., Dasgupta, I., Faconti, L., Glover, M., Heagerty, A. M., Khong, T. K., Lip, G. Y.H., Mander, A. P., Marchong, M. N., Martin, U., McDonnell, B. J., McEniery, C. M., Padmanabhan, S., Saxena, M., Sever, P. J., Shiel, J. I., Wych, J., Chowienczyk, P. J., Wilkinson, I. B. (2018) A randomized controlled crossover trial evaluating differential responses to antihypertensive drugs (used as mono- or dual therapy) on the basis of ethnicity: the comparIsoN oF Optimal Hypertension RegiMens; part of the Ancestry Informative Markers in HYpertension program-AIM-HY INFORM trial. American Heart Journal, 204, pp. 102-108. (doi: 10.1016/j.ahj.2018.05.006)

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Shah, S. J. et al. (2018) One-year safety and clinical outcomes of a transcatheter interatrial shunt device for the treatment of heart failure with preserved ejection fraction in the reduce elevated left atrial pressure in patients with heart failure (REDUCE LAP-HF I) trial: a randomized clinical trial. JAMA Cardiology, 3, pp. 968-977. (doi: 10.1001/jamacardio.2018.2936)

Rosenthal, E. A., Shirts, B. H., Amendola, L. M., Horike-Pyne, M., Robertson, P. D., Hisama, F. M., Bennett, R. L., Dorschner, M. O., Nickerson, D. A., Stanaway, I. B., Nassir, R., Vickers, K. T., Li, C., Grady, W. M., Peters, U., Jarvik, G. P., NHLBI GO Exome Sequencing Project, (2018) Rare loss of function variants in candidate genes and risk of colorectal cancer. Human Genetics, 137, pp. 795-806. (doi: 10.1007/s00439-018-1938-4)

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Gho, J. M.I.H., Schmidt, A. F., Pasea, L., Koudstaal, S., Pujades-Rodriguez, M., Denaxas, S., Shah, A. D., Patel, R. S., Gale, C. P., Hoes, A. W., Cleland, J. G., Hemingway, H., Asselbergs, F. W. (2018) An electronic health records cohort study on heart failure following myocardial infarction in England: incidence and predictors. BMJ Open, 8, (doi: 10.1136/bmjopen-2017-018331)

Taylor, R., Leslie, W. S., Barnes, A. C., Brosnahan, N., Thom, G., McCombie, L., Sattar, N., Welsh, P., Peters, C., Zhyzhneuskaya, S., Hollingsworth, K. G., Al-Mrabeh, A., Rodrigues, A. M., Rehackova, L., Adamson, A. J., Sniehotta, F. F., Mathers, J. C., Ross, H. M., McIlvenna, Y., Kean, S., Ford, I., McConnachie, A., Lean, M. E.J. (2018) Clinical and metabolic features of the randomised controlled Diabetes Remission Clinical Trial (DiRECT) cohort. Diabetologia, 61, pp. 589-598. (doi: 10.1007/s00125-017-4503-0)

Ward, E., Gillies, J., Armstrong, D., Grant, L., Elder, A., Burton, J., Ryan, C., Quinn, C. (2018) Cultivating compassionate care: why does it matter and what can we do to promote it? Journal of the Royal College of Physicians of Edinburgh, 48, pp. 71-77. (doi: 10.4997/jrcpe.2018.117)

Mogensen, U. M., Køber, L., Jhund, P. S., Desai, A. S., Senni, M., Kristensen, S. L., Dukát, A., Chen, C.-H., Ramires, F., Lefkowitz, M. P., Prescott, M. F., Shi, V. C., Rouleau, J. L., Solomon, S. D., Swedberg, K., Packer, M., McMurray, J. J.V. (2018) Sacubitril/valsartan reduces serum uric acid concentration, an independent predictor of adverse outcomes in PARADIGM-HF. European Journal of Heart Failure, 20, pp. 514-522. (doi: 10.1002/ejhf.1056)

Stewart, R. A.H., Szalewska, D., Stebbins, A., Al-Khalidi, H. R., Cleland, J. G.H., Rynkiewicz, A., Drazner, M. H., White, H. D., Mark, D. B., Roy, A., Kosevic, D., Rajda, M., Jasinski, M., Leng, C. Y., Tungsubutra, W., Desvigne-Nickens, P., Velazquez, E. J., Petrie, M. C. (2018) Six-minute walk distance after coronary artery bypass grafting compared with medical therapy in ischaemic cardiomyopathy. Open Heart, 5, (doi: 10.1136/openhrt-2017-000752)

ter Maaten, J. M., Voors, A. A., Damman, K., van der Meer, P., Anker, S. D., Cleland, J. G.F., Dickstein, K., Filippatos, G., van der Harst, P., Hillege, H. L., Lang, C. C., Metra, M., Navis, G., Ng, L., Ouwerkerk, W., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zannad, F., Zwinderman, A. H., de Borst, M. H. (2018) Fibroblast growth factor 23 is related to profiles indicating volume overload, poor therapy optimization and prognosis in patients with new-onset and worsening heart failure. International Journal of Cardiology, 253, pp. 84-90. (doi: 10.1016/j.ijcard.2017.10.010)

Lean, M. E.J. et al. (2018) Primary care-led weight management for remission of type 2 diabetes (DiRECT): an open-label, cluster-randomised trial. Lancet, 391, pp. 541-551. (doi: 10.1016/S0140-6736(17)33102-1)

Conrad, N., Judge, A., Tran, J., Mohseni, H., Hedgecott, D., Crespillo, A. P., Allison, M., Hemingway, H., Cleland, J. G., McMurray, J. J.V., Rahimi, K. (2018) Temporal trends and patterns in heart failure incidence: a population-based study of 4 million individuals. Lancet, 391, pp. 10-16. (doi: 10.1016/S0140-6736(17)32520-5)

Corcoran, D., Young, R., Cialdella, P., McCartney, P., Bajrangee, A., Hennigan, B., Collison, D., Carrick, D., Shaukat, A., Good, R., Watkins, S., McEntegart, M., Watt, J., Welsh, P., Sattar, N., McConnachie, A., Oldroyd, K.G., Berry, C. (2018) The effects of remote ischaemic preconditioning on coronary artery function in patients with stable coronary artery disease. International Journal of Cardiology, 252, pp. 24-30. (doi: 10.1016/j.ijcard.2017.10.082)

Magnus, M. C., Lawlor, D. A., Iliodromiti, S., Padmanabhan, S., Nelson, S. M., Fraser, A. (2018) Age at menarche and cardiometabolic health: a sibling analysis in the Scottish Family Health Study. Journal of the American Heart Association, 7, (doi: 10.1161/JAHA.117.007780)

Welsh, P. (2018) Correlating changes in metabolic status with arterial health: modest associations but any clinical implications? Hypertension, 71, pp. 227-228. (doi: 10.1161/HYPERTENSIONAHA.117.10595)

Rørth, R., Fosbøl, E. L., Mogensen, U. M., Kragholm, K., Numé, A.-k., Gislason, G. H.,, Jhund, P. S., Petrie, M. C., McMurray, J. J.V., Torp-Pedersen, C., Køber, L., Kristensen, S. L. (2018) Employment status at time of first hospitalization for heart failure is associated with death and rehospitalization for heart failure. European Journal of Heart Failure, 20, pp. 240-247. (doi: 10.1002/ejhf.1046)

Cleland, J. G.F. (2018) Physicians Addicted to Prescribing Aspirin-a Disorder Of Cardiologists (PAPA-DOC) Syndrome: the headache of nonevidence-based medicine for ischemic heart disease? JACC: Heart Failure, 6, pp. 168-171. (doi: 10.1016/j.jchf.2017.11.014)

Platz, E., Jhund, P. S., Claggett, B. L., Pfeffer, M. A., Swedberg, K., Granger, C. B., Yusuf, S., Solomon, S. D., McMurray, J. J. (2018) Prevalence and prognostic importance of precipitating factors leading to heart failure hospitalization: recurrent hospitalizations and mortality. European Journal of Heart Failure, 20, pp. 295-303. (doi: 10.1002/ejhf.901)

Nikolaidou, T., Pellicori, P., Zhang, J., Kazmi, S., Goode, K. M., Cleland, J. G., Clark, A. L. (2018) Prevalence, predictors, and prognostic implications of PR interval prolongation in patients with heart failure. Clinical Research in Cardiology, 107, pp. 108-119. (doi: 10.1007/s00392-017-1162-6)

Welsh, P., Kou, L., Yu, C., Anand, I., van Veldhuisen, D. J., Maggioni, A. P., Desai, A. S., Solomon, S. D., Pfeffer, M. A., Cheng, S., Gullestad, L., Aukrust, P., Ueland, T., Swedberg, K., Young, J. B., Kattan, M. W., Sattar, N., McMurray, J. J.V. (2018) Prognostic importance of emerging cardiac, inflammatory, and renal biomarkers in chronic heart failure patients with reduced ejection fraction and anaemia: RED-HF study. European Journal of Heart Failure, 20, pp. 268-277. (doi: 10.1002/ejhf.988)

Emmens, J. E., Jones, D. J.L., Cao, T. H., Chan, D. C.S., Romaine, S. P.R., Quinn, P. A., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., Hillege, H. L., Lang, C. C., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zannad, F., Zwinderman, A. H., Metra, M., de Boer, R. A., Voors, A. A., Ng, L. L. (2018) Proteomic diversity of high-density lipoprotein explains its association with clinical outcome in patients with heart failure. European Journal of Heart Failure, 20, pp. 260-267. (doi: 10.1002/ejhf.1101)

Cotter, G., Metra, M., Davison, B. A., Jondeau, G., Cleland, J. G.F., Bourge, R. C., Milo, O., O'Connor, C. M., Parker, J. D., Torre-Amione, G., van Veldhuisen, D. J., Kobrin, I., Rainisio, M., Senger, S., Edwards, C., McMurray, J. J.V., Teerlink, J. R. (2018) Systolic blood pressure reduction during the first 24 h in acute heart failure admission: friend or foe? European Journal of Heart Failure, 20, pp. 317-322. (doi: 10.1002/ejhf.889)

Stoumpos, S., Lees, J., Welsh, P., Hund, M., Geddes, C. C., Nelson, S. M., Mark, P. B. (2018) The utility of anti-Müllerian hormone in women with chronic kidney disease, on haemodialysis and after kidney transplantation. Reproductive BioMedicine Online, 36, pp. 219-226. (doi: 10.1016/j.rbmo.2017.11.003)

Ouwerkerk, W., Zwinderman, A. H., Ng, L. L., Demissei, B., Hillege, H. L., Zannad, F., van Veldhuisen, D. J., Samani, N. J., Ponikowski, P., Metra, M., ter Maaten, J. M., Lang, C. C., van der Harst, P., Filippatos, G., Dickstein, K., Cleland, J. G., Anker, S. D., Voors, A. A. (2018) Biomarker-guided versus guideline-based treatment of patients with heart failure: results from BIOSTAT-CHF. Journal of the American College of Cardiology, 71, pp. 386-398. (doi: 10.1016/j.jacc.2017.11.041)

van der Wardt, V., Burton, J. K., Conroy, S., Welsh, T., Logan, P., Taggar, J., Tanajewski, L., Gladman, J. (2018) Withdrawal of antihypertensive therapy in people with dementia: feasibility study. Pilot and Feasibility Studies, 4, (doi: 10.1186/s40814-017-0221-0)

Cleland, J. G.F., Flather, M. D., Altman, D. G., Kotecha, D. (2018) Reply: an incomplete story. Journal of the American College of Cardiology, 71, pp. 105. (doi: 10.1016/j.jacc.2017.10.078)

Cleland, J. G.F., Bunting, K. V., Flather, M. D., Altman, D. G., Holmes, J., Coats, A. J.S., Manzano, L., McMurray, J. J.V., Ruschitzka, F., van Veldhuisen, D. J., von Lueder, T. G., Böhm, M., Andersson, B., Kjekshus, J., Packer, M., Rigby, A. S., Rosano, G., Wedel, H., Hjalmarson, Å., Wikstrand, J., Kotecha, D. (2018) Beta-blockers for heart failure with reduced, mid-range, and preserved ejection fraction: an individual patient-level analysis of double-blind randomized trials. European Heart Journal, 39, pp. 26-35. (doi: 10.1093/eurheartj/ehx564)

Kristensen, S. L., Mogensen, U. M., Tarnesby, G., Gimpelewicz, C. R., Ali, M. A., Shao, Q., Chiang, Y., Jhund, P. S., Abraham, W. T., Dickstein, K., McMurray, J. J.V., Køber, L. (2018) Aliskiren alone or in combination with enalapril vs. enalapril among patients with chronic heart failure with and without diabetes: a subgroup analysis from the ATMOSPHERE trial. European Journal of Heart Failure, 20, pp. 136-147. (doi: 10.1002/ejhf.896)

Pellicori, P., Urbinati, A., Zhang, J., Joseph, A. C., Costanzo, P., Lukaschuk, E., Capucci, A., Cleland, J. G.F., Clark, A. L. (2018) Clinical and prognostic relationships of pulmonary artery to aorta diameter ratio in patients with heart failure: a cardiac magnetic resonance imaging study. Clinical Cardiology, 41, pp. 20-27. (doi: 10.1002/clc.22840)

Patel, N., Hellmuth, C., Uhl, O., Godfrey, K., Briley, A., Welsh, P., Pasupathy, D., Seed, P., Koletzko, B., Poston, L. (2018) Cord metabolic profiles In obese pregnant women; insights into offspring growth and body composition. Journal of Clinical Endocrinology and Metabolism, 103, pp. 346-355. (doi: 10.1210/jc.2017-00876)

Arba, F., Quinn, T. J., Hankey, G. J., Lees, K. R., Wardlaw, J. M., Ali, M., Inzitari, D. (2018) Enlarged perivascular spaces and cognitive impairment after stroke and transient ischemic attack. International Journal of Stroke, 13, pp. 47-56. (doi: 10.1177/1747493016666091)

Rørth, R., Fosbøl, E. L., Mogensen, U. M., Kragholm, K., Jhund, P. S., Petrie, M. C., Schou, M., Gislason, G. H., McMurray, J. J.V., Torp-Pedersen, C., Køber, L., Kristensen, S. L. (2018) Evidence based therapy and its association with workforce detachment following first hospitalization for heart failure. JACC: Heart Failure, 6, pp. 41-48. (doi: 10.1016/j.jchf.2017.09.019)

Bihlmeyer, N. A. et al. (2018) ExomeChip-wide analysis of 95 626 individuals identifies 10 novel loci associated with QT and JT intervals. Circulation: Genomic and Precision Medicine, 11, (doi: 10.1161/CIRCGEN.117.001758)

Beggs, S. A.S., Jhund, P. S., Jackson, C. E., McMurray, J. J.V., Gardner, R. S. (2018) Non-ischaemic cardiomyopathy, sudden death and implantable defibrillators: a review and meta-analysis. Heart, 104, pp. 144-150. (doi: 10.1136/heartjnl-2016-310850)

Burton, J. K., Ferguson, E. E.C., Barugh, A. J., Walesby, K. E., MacLullich, A. M.J., Shenkin, S. D., Quinn, T. J. (2018) Predicting discharge to institutional long-term care after stroke: a systematic review and metaanalysis. Journal of the American Geriatrics Society, 66, pp. 161-169. (doi: 10.1111/jgs.15101)

Turcot, V. et al. (2018) Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity. Nature Genetics, 50, pp. 26-41. (doi: 10.1038/s41588-017-0011-x)

Padmanabhan, S., Tan, L.-E., Dominiczak, A. F. (2018) Genetics of blood pressure and hypertension. Springer

McAllister, D. A., Read, S., Kerssens, J., Livingstone, S., McGurnaghan, S., Jhund, P., Petrie, J., Sattar, N., Fischbacher, C., Kristensen, S. L., McMurray, J., Colhoun, H. M., Wild, S. (2018) Incidence of hospitalisation for heart failure and case-fatality among 3.25 million people with and without diabetes. Circulation, 138, pp. 2774-2785. (doi: 10.1161/CIRCULATIONAHA.118.034986)

Rørth, R., Fosbøl, E. L., Kragholm, K., Mogensen, U. M., Jhund, P. S., Petrie, M. C., Torp-Pedersen, C., Gislason, G. H., McMurray, J. J.V., Køber, L., Kristensen, S. L. (2018) Initiation of domiciliary care and nursing home admission following first hospitalization for heart failure: a nationwide cohort study. Clinical Epidemiology, 10, pp. 917-930. (doi: 10.2147/CLEP.S164795)

2017

Todd, A., Blackley, S., Burton, J. K., Stott, D. J., Ely, E. W., Tieges, Z., MacLullich, A. M.J., Shenkin, S. D. (2017) Reduced level of arousal and increased mortality in adult acute medical admissions: a systematic review and meta-analysis. BMC Geriatrics, 17, (doi: 10.1186/s12877-017-0661-7)

Celis-Morales, C. A., Petermann, F., Hui, L., Lyall, D. M., Iliodromiti, S., McLaren, J., Anderson, J., Welsh, P., Mackay, D. F., Pell, J. P., Sattar, N., Gill, J. M.R., Gray, S. R. (2017) Associations between diabetes and both cardiovascular disease and all-cause mortality are modified by grip strength: evidence from UK Biobank, a prospective population-based cohort study. Diabetes Care, 40, pp. 1710-1718. (doi: 10.2337/dc17-0921)

Kaye, D. M., Silvestry, F. E., Gustafsson, F., Cleland, J. G., van Veldhuisen, D. J., Ponikowski, P., Komtebedde, J., Nanayakkara, S., Burkhoff, D., Shah, S. J. (2017) Impact of atrial fibrillation on rest and exercise haemodynamics in heart failure with mid-range and preserved ejection fraction. European Journal of Heart Failure, 19, pp. 1690-1697. (doi: 10.1002/ejhf.930)

Carberry, J., Carrick, D., Haig, C., Ahmed, N., Mordi, I., McEntegart, M., Petrie, M. C., Eteiba, H., Hood, S., Watkins, S., Lindsay, M., Davie, A., Mahrous, A., Ford, I., Sattar, N., Welsh, P., Radjenovic, A., Oldroyd, K. G., Berry, C. (2017) Persistence of infarct zone T2 hyperintensity at 6 months after acute ST-elevation myocardial infarction: incidence, pathophysiology and prognostic implications. Circulation: Cardiovascular Imaging, 10, (doi: 10.1161/CIRCIMAGING.117.006586)

Kristensen, S. L., Jhund, P. S., Lee, M. M.Y., Køber, L., Solomon, S. D., Granger, C. B., Yusuf, S., Pfeffer, M. A., Swedberg, K., McMurray, J. J.V. (2017) Prevalence of prediabetes and undiagnosed diabetes in patients with HFpEF and HFrEF and associated clinical outcomes. Cardiovascular Drugs and Therapy, 31, pp. 545-549. (doi: 10.1007/s10557-017-6754-x)

Vieira, M. C., White, S. L., Patel, N., Seed, P. T., Briley, A. L., Sandall, J., Welsh, P., Sattar, N., Nelson, S. M., Lawlor, D. A., Poston, L., Pasupathy, D. (2017) Prediction of uncomplicated pregnancies in obese women: a prospective multicentre study. BMC Medicine, 15, (doi: 10.1186/s12916-017-0956-8)

Sartini, C., Whincup, P. H., Wannamethee, S. G., Jefferis, B. J., Lennon, L., Lowe, G. D.O., Welsh, P., Sattar, N., Morris, R. W. (2017) Associations of time of day with cardiovascular disease risk factors measured in older men: results from the British Regional Heart Study. BMJ Open, 7, (doi: 10.1136/bmjopen-2017-018264)

MacDonald, T. M., Williams, B., Webb, D. J., Morant, S., Caulfield, M., Cruickshank, J. K., Ford, I., Sever, P., Mackenzie, I. S., Padmanabhan, S., McCann, G. P., Salsbury, J., McInnes, G., Brown, M. J. (2017) Combination therapy is superior to sequential monotherapy for the initial treatment of hypertension: a double-blind randomized controlled trial. Journal of the American Heart Association, 6, (doi: 10.1161/JAHA.117.006986)

Shen, L., Ramires, F., Martinez, F., Bodanese, L. C., Echeverría, L. E., Gómez, E. a., Abraham, W. t., Dickstein, K., Køber, L., Packer, M., Rouleau, J. L., Solomon, S. D., Swedberg, K., Zile, M. R., Jhund, P. S., Gimpelewicz, C. R., McMurray, J. J.V. (2017) Contemporary characteristics and outcomes in chagasic heart failure compared with other nonischemic and ischemic cardiomyopathy. Circulation: Heart Failure, 10, (doi: 10.1161/CIRCHEARTFAILURE.117.004361)

Holman, R. R., Coleman, R. L., Chan, J. C. N., Chiasson, J.-L., Feng, H., Ge, J., Gerstein, H. C., Gray, R., Huo, Y., Lang, Z., McMurray, J. J., Rydén, L., Schröder, S., Sun, Y., Theodorakis, M. J., Tendera, M., Tucker, L., Tuomilehto, J., Wei, Y., Yang, W., Wang, D., Hu, D., Pan, C., ACE Study Group, (2017) Effects of acarbose on cardiovascular and diabetes outcomes in patients with coronary heart disease and impaired glucose tolerance (ACE): a randomised, double-blind, placebo-controlled trial. Lancet Diabetes and Endocrinology, 5, pp. 877-886. (doi: 10.1016/S2213-8587(17)30309-1)

Wong, C. M., Hawkins, N. M., Ezekowitz, J. A., Jhund, P. S., Savu, A., MacDonald, M. R., Kristensen, S. L., Petrie, M. C., McMurray, J. J.V., McAlister, F. A., Kaul, P. (2017) Heart failure in young adults is associated with high mortality: a contemporary population-level analysis. Canadian Journal of Cardiology, 33, pp. 1472-1477. (doi: 10.1016/j.cjca.2017.05.009)

Welsh, P., Grassia, G., Botha, S., Sattar, N., Maffia, P. (2017) Targeting inflammation to reduce cardiovascular disease risk: a realistic clinical prospect? British Journal of Pharmacology, 174, pp. 3898-3913. (doi: 10.1111/bph.13818)

Mogensen, U. M., Jhund, P. S., Abraham, W. T., Desai, A. S., Dickstein, K., Packer, M., Rouleau, J. L., Solomon, S. D., Swedberg, K., Zile, M. R., Køber, L., McMurray, J. J.V. (2017) Type of atrial fibrillation and clinical outcomes in patients with heart failure and reduced ejection fraction. Journal of the American College of Cardiology, 70, pp. 2490-2500. (doi: 10.1016/j.jacc.2017.09.027)

Rutherford, E., Mangion, K., Mccomb, C., Bell, E., Cockburn, S., Talle, M., Roditi, G., Welsh, P., Woodward, R., Radjenovic, A., Struthers, A. D., Jardine, A., Berry, C., Patel, R. K., Mark, P. B. (2017) Myocardial changes in incident haemodialysis patients over 6-months: an observational cardiac magnetic resonance imaging study. Scientific Reports, 7, (doi: 10.1038/s41598-017-14481-y)

Bayes-Genis, A., Núñez, J., Zannad, F., Ferreira, J. P., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., Lang, C. C., Ng, L. L., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zwinderman, A. H., Metra, M., Lupón, J., Voors, A. A. (2017) The PCSK9-LDL receptor axis and outcomes in heart failure: BIOSTAT-CHF subanalysis. Journal of the American College of Cardiology, 70, pp. 2128-2136. (doi: 10.1016/j.jacc.2017.08.057)

Sharma, A., Demissei, B. G., Tromp, J., Hillege, H. L., Cleland, J. G.F., O'Connor, C. M., Metra, M., Ponikowski, P., Teerlink, J. R., Davison, B. A., Givertz, M. M., Bloomfield, D. M., Dittrich, H., van Veldhuisen, D. J., Cotter, G., Ezekowitz, J. A., Khan, M. A.F., Voors, A. A. (2017) A network analysis to compare biomarker profiles in patients with and without diabetes mellitus in acute heart failure. European Journal of Heart Failure, 19, pp. 1310-1320. (doi: 10.1002/ejhf.912)

Clarke, T.-K., Adams, M.J., Davies, G., Howard, D.M., Hall, L.S., Padmanabhan, S., Murray, A.D., Smith, B.H., Campbell, A., Hayward, C., Porteous, D.J., Deary, I.J., McIntosh, A.M. (2017) Genome-wide association study of alcohol consumption and genetic overlap with other health-related traits in UK Biobank (N=112 117) Molecular Psychiatry, 22, pp. 1376-1384. (doi: 10.1038/mp.2017.153)

White, S. L., Pasupathy, D., Sattar, N., Nelson, S. M., Lawlor, D. A., Briley, A. L., Seed, P. T., Welsh, P., Poston, L. (2017) Metabolic profiling of gestational diabetes in obese women during pregnancy. Diabetologia, 60, pp. 1903-1912. (doi: 10.1007/s00125-017-4380-6)

Ferreira, J. P., Rossignol, P., Machu, J.-L., Sharma, A., Girerd, N., Anker, S. D., Cleland, J. G., Dickstein, K., Filippatos, G., Hillege, H. L., Lang, C. C., Ter Maaten, J., Metra, M., Ng, L., Ponikowski, P., Samani, N. J., van Veldhuisen, D. J., Zwinderman, A. H., Voors, A., Zannad, F. (2017) Mineralocorticoid receptor antagonist pattern of use in heart failure with reduced ejection fraction: findings from BIOSTAT-CHF. European Journal of Heart Failure, 19, pp. 1284-1293. (doi: 10.1002/ejhf.900)

Kraja, A. T. et al. (2017) New blood pressure–associated loci identified in meta-analyses of 475 000 individuals. Circulation: Cardiovascular Genetics, 10, (doi: 10.1161/CIRCGENETICS.117.001778)

Nassif, M. E., Tang, Y., Cleland, J. G.F., Abraham, W. T., Linde, C., Gold, M. R., Young, J. B., Daubert, J. C., Sherfesee, L., Schaber, D., Tang, A. S.L., Jones, P. G., Arnold, S. V., Spertus, J. A. (2017) Precision medicine for cardiac resynchronization: predicting quality of life benefits for individual patients-an analysis from 5 clinical trials. Circulation: Heart Failure, 10, (doi: 10.1161/CIRCHEARTFAILURE.117.004111)

Kristensen, S. L., Jhund, P. S., Mogensen, U. M., Rørth, R., Abraham, W. T., Desai, A., Dickstein, K., Rouleau, J. L., Zile, M. R., Swedberg, K., Packer, M., Solomon, S. D., Køber, L., McMurray, J. J.V. (2017) Prognostic value of N-terminal pro-B-type natriuretic peptide levels in heart failure patients with and without atrial fibrillation. Circulation: Heart Failure, 10, (doi: 10.1161/CIRCHEARTFAILURE.117.004409)

Padmanabhan, S., Joe, B. (2017) Towards precision medicine for hypertension: a review of genomic, epigenomic, and microbiomic effects on blood pressure in experimental rat models and humans. Physiological Reviews, 97, pp. 1469-1528. (doi: 10.1152/physrev.00035.2016)

Cleland, J. G.F., Halliday, B. P., Prasad, S. K. (2017) Selecting patients with nonischemic dilated cardiomyopathy for ICDs. Journal of the American College of Cardiology, 70, pp. 1228-1231. (doi: 10.1016/j.jacc.2017.07.748)

Zeng, Y. et al. (2017) Genome-wide regional heritability mapping identifies a locus within the TOX2 gene associated with major depressive disorder. Biological Psychiatry, 82, pp. 312-321. (doi: 10.1016/j.biopsych.2016.12.012)

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Nagy, R. et al. (2017) Exploration of haplotype research consortium imputation for genome-wide association studies in 20,032 Generation Scotland participants. Genome Medicine, 9, (doi: 10.1186/s13073-017-0414-4)

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Sartini, C., Barry, S. J.E., Whincup, P. H., Wannamethee, S. G., Lowe, G. D.O., Jefferis, B. J., Lennon, L., Welsh, P., Ford, I., Sattar, N., Morris, R. W. (2017) Relationship between outdoor temperature and cardiovascular disease risk factors in older people. European Journal of Preventive Cardiology, 24, pp. 349-356. (doi: 10.1177/2047487316682119)

Masters, J., Morton, G., Anton, I., Szymanski, J., Greenwood, E., Grogono, J., Flett, A. S., Cleland, J. G.F., Cowburn, P. J. (2017) Specialist intervention is associated with improved patient outcomes in patients with decompensated heart failure: evaluation of the impact of a multidisciplinary inpatient heart failure team. Open Heart, 4, (doi: 10.1136/openhrt-2016-000547)

Preiss, D., Dawed, A., Welsh, P., Heggie, A., Jones, A. G., Dekker, J., Koivula, R., Hansen, T. H., Stewart, C., Holman, R. R., Franks, P. W., Walker, M., Pearson, E. R., Sattar, N. (2017) Sustained influence of metformin therapy on circulating glucagon-like peptide-1 levels in individuals with and without type 2 diabetes. Diabetes, Obesity and Metabolism, 19, pp. 356-363. (doi: 10.1111/dom.12826)

Dierckx, R., Inglis, S. C., Clark, R. A., Prieto-Merino, D., Cleland, J. G.F. (2017) Telemedicine in heart failure: new insights from the Cochrane meta-analyses. European Journal of Heart Failure, 19, pp. 304-306. (doi: 10.1002/ejhf.759)

Carty, D. M., Doogan, F., Welsh, P., Dominiczak, A. F., Delles, C. (2017) Thyroid stimulating hormone (TSH) ≥2.5mU/l in early pregnancy: prevalence and subsequent outcomes. European Journal of Obstetrics and Gynecology and Reproductive Biology, 210, pp. 366-369. (doi: 10.1016/j.ejogrb.2017.01.048)

MacIsaac, R. L., Ali, M., Taylor-Rowan, M., Rodgers, H., Lees, K. R., Quinn, T. J. (2017) Use of a 3-item short-form version of the Barthel Index for use in stroke. Stroke, 48, pp. 618-623. (doi: 10.1161/STROKEAHA.116.014789)

van Hecke, O., Hocking, L. J., Torrance, N., Campbell, A., Padmanabhan, S., Porteous, D. J., McIntosh, A. M., Burri, A. V., Tanaka, H., Williams, F. M.K.>, Smith, B. H. (2017) Chronic pain, depression and cardiovascular disease linked through a shared genetic predisposition: Analysis of a family-based cohort and twin study. PLoS ONE, 12, (doi: 10.1371/journal.pone.0170653)

Zeng, Y., Navarro, P., Fernandez-Pujals, A. M., Hall, L. S., Clarke, T.-K., Thomson, P. A., Smith, B. H., Hocking, L. J., Padmanabhan, S., Hayward, C., MacIntyre, D. J., Wray, N. R., Deary, I. J., Porteous, D. J., Haley, C. S., McIntosh, A. M. (2017) A combined pathway and regional heritability analysis indicates NETRIN1 pathway is associated with major depressive disorder. Biological Psychiatry, 81, pp. 336-346. (doi: 10.1016/j.biopsych.2016.04.017)

Marouli, E. et al. (2017) Rare and low-frequency coding variants alter human adult height. Nature, 542, pp. 186-190. (doi: 10.1038/nature21039)

Docherty, K. F., Campbell, R. T., Jhund, P., Petrie, M. C., McMurray, J. J.V. (2017) How robust are clinical trials in heart failure? European Heart Journal, 38, pp. 338-345. (doi: 10.1093/eurheartj/ehw427)

Emdin, C. A., Hsiao, A. J., Kiran, A., Conrad, N., Salimi-Khorshidi, G., Woodward, M., Anderson, S. G., Mohseni, H., McMurray, J. J.V., Cleland, J. G.F., Dargie, H., Hardman, S., McDonagh, T., Rahimi, K. (2017) Referral for specialist follow-up and its association with post-discharge mortality among patients with systolic heart failure (from the National Heart Failure Audit for England and Wales) American Journal of Cardiology, 119, pp. 440-444. (doi: 10.1016/j.amjcard.2016.10.021)

Arba, F., Quinn, T., Hankey, G.J., Ali, M., Lees, K. R., Inzitari, D. (2017) Cerebral small vessel disease, medial temporal lobe atrophy and cognitive status in patients with ischaemic stroke and transient ischaemic attack. European Journal of Neurology, 24, pp. 276-282. (doi: 10.1111/ene.13191)

Schmidt, A. F. et al. (2017) PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study. Lancet Diabetes and Endocrinology, 5, pp. 97-105. (doi: 10.1016/S2213-8587(16)30396-5)

Gastelurrutia, P., Lupón, J., Domingo, M., Stut, W., Dovancescu, S., Cleland, J., Frankenstein, L., Bayes-Genis, A. (2017) Potential role for clinical calibration to increase engagement with and application of home telemonitoring: a report from the HeartCycle programme. ESC Heart Failure, 4, pp. 66-70. (doi: 10.1002/ehf2.12104)

Zhang, J., Dierckx, R., Mohee, K., Clark, A. L., Cleland, J. G.F. (2017) Xanthine oxidase inhibition for the treatment of cardiovascular disease: an updated systematic review and meta-analysis. ESC Heart Failure, 4, pp. 40-45. (doi: 10.1002/ehf2.12112)

Schulz, C., Padmanabhan, S. (2017) Methods to assess genetic risk prediction. Springer

Tsiropoulou, S., McBride, M., Padmanabhan, S. (2017) Urine metabolomics in hypertension research. Springer

Jeemon, P., Harikrishnan, S., Sanjay, G., Sivasubramonian, S., Lekha, T.R., Padmanabhan, S., Tandon, N., Prabhakaran, D. (2017) A PROgramme of Lifestyle Intervention in Families for Cardiovascular risk reduction (PROLIFIC Study): design and rationale of a family based randomized controlled trial in individuals with family history of premature coronary heart disease. BMC Public Health, 17, (doi: 10.1186/s12889-016-3928-6)

Cannon, J. A., Shen, L., Jhund, P. S., Kristensen, S. L., Køber, L., Chen, F., Gong, J., Lefkowitz, M. P., Rouleau, J. L., Shi, V. C., Swedberg, K., Zile, M. R., Solomon, S. D., Packer, M., McMurray, J. J.V. (2017) Dementia-related adverse events in PARADIGM-HF and other trials in heart failure with reduced ejection fraction. European Journal of Heart Failure, 19, pp. 129-137. (doi: 10.1002/ejhf.687)

Streng, K. W., ter Maaten, J. M., Cleland, J. G.F., O’Connor, C. M., Davison, B. A., Metra, M., Givertz, M. M., Teerlink, J. R., Ponikowski, P., Bloomfield, D. M., Dittrich, H. C., Hillege, H. L., van Veldhuisen, D. J., Voors, A. A., van der Meer, P. (2017) Associations of body mass index with laboratory and biomarkers in patients with acute heart failure. Circulation: Heart Failure, 10, (doi: 10.1161/CIRCHEARTFAILURE.116.003350)

Kristensen, S. L., Mogensen, U. M., Jhund, P. S., Petrie, M. C., Preiss, D., Win, S., Køber, L., McKelvie, R. S., Zile, M. R., Anand, I. S., Komajda, M., Gottdiener, J. S., Carson, P. E., McMurray, J. J.V. (2017) Clinical and echocardiographic characteristics and cardiovascular outcomes according to diabetes status in patients with heart failure and preserved ejection fraction. A report from the Irbesartan in Heart Failure with Preserved Ejection Fraction Trial (I-Preserve) Circulation, 135, pp. 724-735. (doi: 10.1161/CIRCULATIONAHA.116.024593)

Salvi, E. et al. (2017) Genome-wide and gene-based meta-analyses identify novel loci influencing blood pressure response to hydrochlorothiazide. Hypertension, 69, pp. 51-59. (doi: 10.1161/HYPERTENSIONAHA.116.08267)

Tromp, J., ter Maaten, J., Damman, K., O’Connor, C. M., Metra, M., Dittrich, H. C., Ponikowski, P., Teerlink, J. R., Cotter, G., Davison, B., Cleland, J. G.F., Givertz, M. M., Bloomfield, D. M., van der Wal, M. H.L., Jaarsma, T., van Veldhuisen, D. J., Hillege, H. L., Voors, A. A., van der Meer, P. (2017) Serum potassium levels and outcome in acute heart failure (data from the PROTECT and COACH trials) American Journal of Cardiology, 119, pp. 290-296. (doi: 10.1016/j.amjcard.2016.09.038)

Ridker, P. M. et al. (2017) Cardiovascular efficacy and safety of Bococizumab in high-risk patients. New England Journal of Medicine, 376, pp. 1527-1539. (doi: 10.1056/NEJMoa1701488)

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Power, R. A. et al. (2017) Genome-wide association for major depression through age at onset stratification: major depressive disorder working group of the psychiatric genomics consortium. Biological Psychiatry, 81, pp. 325-335. (doi: 10.1016/j.biopsych.2016.05.010)

Burton, J.K., Quinn, T.J., Gordon, A.L., MacLullich, A.M.J., Reynish, E.L., Shenkin, S.D. (2017) Identifying published studies of care home research: an international survey of researchers. Journal of Nursing Home Research, 3, pp. 99-102. (doi: 10.14283/jnhrs.2017.15)

Arain, F., Gullestad, L., Nymo, S., Kjekshus, J., Cleland, J. G.F., Michelsen, A., McMurray, J. J.V., Wikstrand, J., Aukrust, P., Ueland, T. (2017) Low YKL-40 in Chronic Heart Failure may predict beneficial effects of statins: Analysis from the Controlled Rosuvastatin Multinational Trial in Heart Failure (CORONA) Biomarkers, 22, pp. 261-267. (doi: 10.1080/1354750X.2016.1204003)

2016

Torabi, A., Cleland, J. G.F., Sherwi, N., Atkin, P., Panahi, H., Kilpatrick, E., Thackray, S., Hoye, A., Alamgir, F., Goode, K., Rigby, A., Clark, A. L. (2016) Influence of case definition on incidence and outcome of acute coronary syndromes. Open Heart, 3, (doi: 10.1136/openhrt-2016-000487)

Teerlink, J. R., Felker, G. M., McMurray, J. J.V., Solomon, S. D., Adams, Jr., K. F., Cleland, J. G.F., Ezekowitz, J. A., Goudev, A., Macdonald, P., Metra, M., Mitrovic, V., Ponikowski, P., Serpytis, P., Spinar, J., Tomcsányi, J., Vandekerckhove, H. J., Voors, A. A., Monsalvo, M. L., Johnston, J., Malik, F. I., Honarpour, N. (2016) Chronic oral study of myosin activation to increase contractility in heart failure (COSMIC-HF): a phase 2, pharmacokinetic, randomised, placebo-controlled trial. Lancet, 388, pp. 2895-2903. (doi: 10.1016/S0140-6736(16)32049-9)

White, S. L., Lawlor, D. A., Briley, A. L., Godfrey, K. M., Nelson, S. M., Oteng-Ntim, E., Robson, S. C., Sattar, N., Seed, P. T., Vieira, M. C., Welsh, P., Whitworth, M., Poston, L., Pasupathy, D. (2016) Early antenatal prediction of gestational diabetes in obese women: development of prediction tools for targeted intervention. PLoS ONE, 11, (doi: 10.1371/journal.pone.0167846)

Vegter, E. L., Schmitter, D., Hagemeijer, Y., Ovchinnikova, E. S., van der Harst, P., Teerlink, J. R., O'Connor, C. M., Metra, M., Davison, B. A., Bloomfield, D., Cotter, G., Cleland, J. G.F., Givertz, M. M., Ponikowski, P., van Veldhuisen, D. J., van der Meer, P., Berezikov, E., Voors, A. A., Khan, M. A.F. (2016) Use of biomarkers to establish potential role and function of circulating microRNAs in acute heart failure. International Journal of Cardiology, 224, pp. 231-239. (doi: 10.1016/j.ijcard.2016.09.010)

Pellicori, P., Cleland, J. G.F., Zhang, J., Kallvikbacka-Bennett, A., Urbinati, A., Shah, P., Kazmi, S., Clark, A. L. (2016) Cardiac dysfunction, congestion and loop diuretics: their relationship to prognosis in heart failure. Cardiovascular Drugs and Therapy, 30, pp. 599-609. (doi: 10.1007/s10557-016-6697-7)

Zeng, Y., Navarro, P., Xia, C., Amador, C., Fernandez-Pujals, A. M., Thomson, P. A., Campbell, A., Nagy, R., Clarke, T.-K., Hafferty, J. D., Smith, B. H., Hocking, L. J., Padmanabhan, S., Hayward, C., MacIntyre, D. J., Porteous, D. J., Haley, C. S., McIntosh, A. M. (2016) Shared genetics and couple-associated environment are major contributors to the risk of both clinical and self-declared depression. EBioMedicine, 14, pp. 161-167. (doi: 10.1016/j.ebiom.2016.11.003)

Harrison, J. K., Stott, D. J., McShane, R., Noel-Storr, A. H., Swann-Price, R. S., Quinn, T. J. (2016) Informant questionnaire on cognitive decline in the elderly (IQCODE) for the early diagnosis of dementia across a variety of healthcare settings. Cochrane Database of Systematic Reviews, 2016, (doi: 10.1002/14651858.cd011333.pub2)

Harrison, J. K., Noel-Storr, A. H., Demeyere, N., Reynish, E. L., Quinn, T. J. (2016) Outcomes measures in a decade of dementia and mild cognitive impairment trials. Alzheimer's Research and Therapy, 8, (doi: 10.1186/s13195-016-0216-8)

Inglis, S. C., Clark, R. A., Dierckx, R., Prieto-Merino, D., Cleland, J. G.F. (2016) Structured telephone support or non-invasive telemonitoring for patients with heart failure. Heart, 103, pp. 255-257. (doi: 10.1136/heartjnl-2015-309191)

Demissei, B. G., Postmus, D., Liu, L. C.Y., Cleland, J. G.F., O'Connor, C. M., Metra, M., Ponikowski, P., Teerlink, J. R., Cotter, G., Davison, B. A., Edwards, C., Givertz, M. M., Bloomfield, D. M., Dittrich, H. C., Voors, A. A., Hillege, H. L. (2016) Risk-based evaluation of efficacy of rolofylline in patients hospitalized with acute heart failure — Post-hoc analysis of the PROTECT trial. International Journal of Cardiology, 223, pp. 967-975. (doi: 10.1016/j.ijcard.2016.08.271)

Ferreira, J. P., Girerd, N., Pellicori, P., Duarte, K., Girerd, S., Pfeffer, M. A., McMurray, J. J.V., Pitt, B., Dickstein, K., Jacobs, L., Staessen, J. A., Butler, J., Latini, R., Masson, S., Mebazaa, A., Rocca, H. P. B.-L., Delles, C., Heymans, S., Sattar, N., Jukema, J. W., Cleland, J. G.F., Zannad, F., Rossignol, P. (2016) Renal function estimation and Cockroft–Gault formulas for predicting cardiovascular mortality in population-based, cardiovascular risk, heart failure and post-myocardial infarction cohorts: the Heart ‘OMics’ in AGEing (HOMAGE) and the high-risk myocardial infarction database initiatives. BMC Medicine, 14, (doi: 10.1186/s12916-016-0731-2)

Jhund, P. S. (2016) Geographic variation in heart failure - a matter of celebration or condemnation? European Journal of Heart Failure, 18, pp. 1329-1330. (doi: 10.1002/ejhf.652)

Harrison, J. K., Van Der Wardt, V., Conroy, S. P., Stott, D. J., Dening, T., Gordon, A. L., Logan, P., Welsh, T. J., Taggar, J., Harwood, R., Gladman, J. R.F. (2016) New horizons: the management of hypertension in people with dementia. Age and Ageing, 45, pp. 740-746. (doi: 10.1093/ageing/afw155)

Jongstra, S., Harrison, J. K., Quinn, T. J., Richard, E. (2016) Antihypertensive withdrawal for the prevention of cognitive decline. Cochrane Database of Systematic Reviews, 2016, (doi: 10.1002/14651858.cd011971.pub2)

Bekfani, T., Pellicori, P., Morris, D. A., Ebner, N., Valentova, M., Steinbeck, L., Wachter, R., Elsner, S., Sliziuk, V., Schefold, J. C., Sandek, A., Doehner, W., Cleland, J. G.F., Lainscak, M., Anker, S. D., von Haehling, S. (2016) Sarcopenia in patients with heart failure with preserved ejection fraction: impact on muscle strength, exercise capacity and quality of life. International Journal of Cardiology, 222, pp. 41-46. (doi: 10.1016/j.ijcard.2016.07.135)

Petrie, M. C., Jhund, P. S., She, L., Adlbrecht, C., Doenst, T., Panza, J. A., Hill, J. A., Lee, K. L., Rouleau, J. L., Prior, D. L., Ali, I. S., Maddury, J., Golba, K. S., White, H. D., Carson, P., Chrzanowski, L., Romanov, A., Miller, A. B., Velazquez, E. J. (2016) Ten-year outcomes after coronary artery bypass grafting according to age in patients with heart failure and left ventricular systolic dysfunction: an analysis of the extended follow-up of the STICH Trial (Surgical Treatment for Ischemic Heart Failure) Circulation, 134, pp. 1314-1324. (doi: 10.1161/CIRCULATIONAHA.116.024800)

Desai, A. S., Jhund, P. S. (2016) After TOPCAT: what to do now in heart failure with preserved ejection fraction. European Heart Journal, 37, pp. 3135-3140. (doi: 10.1093/eurheartj/ehw114)

Welsh, P., Tuckwell, K., McInnes, I. B., Sattar, N. (2016) Effect of IL-6 receptor blockade on high-sensitivity troponin T and NT-proBNP in rheumatoid arthritis. Atherosclerosis, 254, pp. 167-171. (doi: 10.1016/j.atherosclerosis.2016.10.016)

Preiss, D., Rankin, N., Welsh, P., Holman, R.R., Kangas, A.J., Soininen, P., Würtz, P., Ala-Korpela, M., Sattar, N. (2016) Effect of metformin therapy on circulating amino acids in a randomized trial: the CAMERA study. Diabetic Medicine, 33, pp. 1569-1574. (doi: 10.1111/dme.13097)

Gillespie, J., Beverland, I. J., Hamilton, S., Padmanabhan, S. (2016) Development, evaluation, and comparison of land use regression modeling methods to estimate residential exposure to nitrogen dioxide in a cohort study. Environmental Science and Technology, 50, pp. 11085-11093. (doi: 10.1021/acs.est.6b02089)

Tromp, J., Meyer, S., Mentz, R. J., O'Connor, C. M., Metra, M., Dittrich, H. C., Ponikowski, P., Teerlink, J. R., Cotter, G., Davison, B., Cleland, J. G.F., Givertz, M. M., Bloomfield, D. M., van Veldhuisen, D. J., Hillege, H. L., Voors, A. A., van der Meer, P. (2016) Acute heart failure in the young: clinical characteristics and biomarker profiles. International Journal of Cardiology, 221, pp. 1067-1072. (doi: 10.1016/j.ijcard.2016.06.339)

Boal, A. H., Smith, D. J., Mccallum, L., Muir, S., Touyz, R. M., Dominiczak, A. F., Padmanabhan, S. (2016) Monotherapy with major antihypertensive drug classes and risk of hospital admissions for mood disorders. Hypertension, 68, pp. 1132-1138. (doi: 10.1161/HYPERTENSIONAHA.116.08188)

Rørth, R., Wong, C., Kragholm, K., Fosbøl, E. L., Mogensen, U. M., Lamberts, M., Petrie, M. C., Jhund, P. S., Gerds, T. A., Torp-Pedersen, C., Gislason, G. H., McMurray, J. J.V., Køber, L., Kristensen, S. L. (2016) Return to the workforce following first hospitalization for heart failure: a Danish nationwide cohort study. Circulation, 134, pp. 999-1009. (doi: 10.1161/CIRCULATIONAHA.116.021859)

Sokoreli, I., de Vries, J.J.G., Riistama, J.M., Pauws, S.C., Steyerberg, E.W., Tesanovic, A., Geleijnse, G., Goode, K.M., Crundall-Goode, A., Kazmi, S., Cleland, J.G.F., Clark, A.L. (2016) Depression as an independent prognostic factor for all-cause mortality after a hospital admission for worsening heart failure. International Journal of Cardiology, 220, pp. 202-207. (doi: 10.1016/j.ijcard.2016.06.068)

Rutherford, E., Talle, M. A., Mangion, K., Bell, E., Rauhalammi, S. M., Roditi, G., McComb, C., Radjenovic, A., Welsh, P., Woodward, R., Struthers, A. D., Jardine, A. G., Patel, R. K., Berry, C., Mark, P. B. (2016) Definition of myocardial tissue abnormalities in end stage renal failure with cardiac magnetic resonance imaging using T1 mapping. Kidney International, 90, pp. 845-852. (doi: 10.1016/j.kint.2016.06.014)

Willeit, P. et al. (2016) Natriuretic peptides and integrated risk assessment for cardiovascular disease: an individual-participant-data meta-analysis. Lancet Diabetes and Endocrinology, 4, pp. 840-849. (doi: 10.1016/S2213-8587(16)30196-6)

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ter Maaten, J. M., Valente, M. A.E., Metra, M., Bruno, N., O’Connor, C. M., Ponikowski, P., Teerlink, J. R., Cotter, G., Davison, B., Cleland, J. G.F., Givertz, M. M., Bloomfield, D. M., Dittrich, H. C., van Veldhuisen, D. J., Hillege, H. L., Damman, K., Voors, A. A. (2016) A combined clinical and biomarker approach to predict diuretic response in acute heart failure. Clinical Research in Cardiology, 105, pp. 145-153. (doi: 10.1007/s00392-015-0896-2)

Brown, M. J., Williams, B., Morant, S. V., Webb, D. J., Caulfield, M. J., Cruickshank, J. K., Ford, I., McInnes, G., Sever, P., Salsbury, J., Mackenzie, I. S., Padmanabhan, S., MacDonald, T. M. (2016) Effect of amiloride, or amiloride plus hydrochlorothiazide, versus hydrochlorothiazide on glucose tolerance and blood pressure (PATHWAY-3): a parallel-group, double-blind randomised phase 4 trial. Lancet Diabetes and Endocrinology, 4, pp. 136-147. (doi: 10.1016/s2213-8587(15)00377-0)

Bhandari, S., Ives, N., Brettell, E. A., Valente, M., Cockwell, P., Topham, P. S., Cleland, J. G.F., Khwaja, A., El Nahas, M. (2016) Multicentre randomized controlled trial of angiotensin-converting enzyme inhibitor/angiotensin receptor blocker withdrawal in advanced renal disease: the STOP-ACEi trial. Nephrology Dialysis Transplantation, 31, pp. 255-261. (doi: 10.1093/ndt/gfv346)

Welsh, P., Hart, C., Papacosta, O., Preiss, D., McConnachie, A., Murray, H., Ramsay, S., Upton, M., Watt, G., Whincup, P., Wannamethee, G., Sattar, N. (2016) Prediction of cardiovascular disease risk by cardiac biomarkers in 2 United Kingdom cohort studies: does utility depend on risk thresholds for treatment? Hypertension, 2016, pp. 309-315. (doi: 10.1161/HYPERTENSIONAHA.115.06501)

Johnson, M. R. et al. (2016) Systems genetics identifies a convergent gene network for cognition and neurodevelopmental disease. Nature Neuroscience, 19, pp. 223-232. (doi: 10.1038/nn.4205)

Carrick, D., Haig, C., Rauhalammi, S., Clerfond, G., Ahmed, N., Mordi, I., McEntegart, M., Petrie, M., Eteiba, H., Hood, S., Watkins, S., Lindsay, M. M., Mahrous, A., Welsh, P., Sattar, N., Ford, I., Oldroyd, K., Radjenovic, A., Berry, C. (2016) Temporal evolution of myocardial hemorrhage and edema in patients after acute ST-elevation myocardial infarction: pathophysiologic insights and clinical implications. Journal of the American Heart Association, 5, (doi: 10.1161/JAHA.115.002834)

Rankinen, T. et al. (2016) No evidence of a common DNA variant profile specific to world class endurance athletes. PLoS ONE, 11, (doi: 10.1371/journal.pone.0147330)

Bruno, N., ter Maaten, J. M., Ovchinnikova, E. S., Vegter, E. L., Valente, M. A.E., van der Meer, P., de Boer, R. A., van der Harst, P., Schmitter, D., Metra, M., O'Connor, C. M., Ponikowski, P., Teerlink, J. R., Cotter, G., Davison, B., Cleland, J. G.F., Givertz, M. M., Bloomfield, D. M., Dittrich, H. C., Pinto, Y. M., van Veldhuisen, D. J., Hillege, H. L., Berezikov, E., Voors, A. A. (2016) MicroRNAs relate to early worsening of renal function in patients with acute heart failure. International Journal of Cardiology, 203, pp. 564-569. (doi: 10.1016/j.ijcard.2015.10.217)

Zhang, J., Hobkirk, J., Carroll, S., Pellicori, P., Clark, A. L., Cleland, J. G.F. (2016) Exploring quality of life in patients with and without heart failure. International Journal of Cardiology, 202, pp. 676-684. (doi: 10.1016/j.ijcard.2015.09.076)

Zile, M. R., Jhund, P., Baicu, C. F., Claggett, B. L., Pieske, B., Voors, A. A., Prescott, M. F., Shi, V., Lefkowitz, M., McMurray, J., Solomon, S. D. (2016) Plasma biomarkers reflecting profibrotic processes in heart failure with a preserved ejection fraction. Circulation: Heart Failure, 9, (doi: 10.1161/circheartfailure.115.002551)

Kristensen, S. L., Preiss, D., Jhund, P. S., Squire, I., Cardoso, J. S., Merkely, B., Martinez, F., Starling, R. C., Desai, A. S., Lefkowitz, M. P., Rizkala, A. R., Rouleau, J. L., Shi, V. C., Solomon, S. D., Swedberg, K., Zile, M. R., McMurray, J. J.V., Packer, M. (2016) Risk related to pre–diabetes mellitus and diabetes mellitus in heart failure with reduced ejection fraction: insights from prospective comparison of ARNI with ACEI to determine impact on global mortality and morbidity in heart failure trial. Circulation: Heart Failure, 9, (doi: 10.1161/CIRCHEARTFAILURE.115.002560)

Jenkins, P., Sng, S., Brooksbank, K., Brooksbank, A.J. (2016) Socioeconomic deprivation and age are barriers to the online collection of patient reported outcome measures in orthopaedic patients. Annals of the Royal College of Surgeons of England, 98, pp. 40-44. (doi: 10.1308/rcsann.2016.0007)

Cowie, M. R., Bax, J., Bruining, N., Cleland, J. G.F., Koehler, F., Malik, M., Pinto, F., van der Velde, E., Vardas, P. (2016) e-Health: a position statement of the European Society of Cardiology. European Heart Journal, 37, pp. 63-66. (doi: 10.1093/eurheartj/ehv416)

Ponikowski, P., Voors, A. A., Anker, S. D., Bueno, H., Cleland, J. G.F., Coats, A. J.S., Falk, V., González-Juanatey, J. R., Harjola, V.-P., Jankowska, E. A., Jessup, M., Linde, C., Nihoyannopoulos, P., Parissis, J. T., Pieske, B., Riley, J. P., Rosano, G. M.C., Ruilope, L. M., Ruschitzka, F., Rutten, F. H., van der Meer, P., McMurray, J. J.V., Petrie, M. C. (2016) 2016 ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure. European Heart Journal, 37, pp. 2129-2200. (doi: 10.1093/eurheartj/ehw128)

Nuesch, E. et al. (2016) Adult height, coronary heart disease and stroke: a multi-locus Mendelian randomization meta-analysis. International Journal of Epidemiology, 45, pp. 1927-1937. (doi: 10.1093/ije/dyv074)

Rankin, N. J., Preiss, D., Welsh, P., Sattar, N. (2016) Applying metabolomics to cardiometabolic intervention studies and trials: past experiences and a roadmap for the future. International Journal of Epidemiology, 45, pp. 1351-1371. (doi: 10.1093/ije/dyw271)

Platz, E., Lewis, E. F., Uno, H., Peck, J., Pivetta, E., Merz, A. A., Hempel, D., Wilson, C., Frasure, S. E., Jhund, P. S., Cheng, S., Solomon, S. D. (2016) Detection and prognostic value of pulmonary congestion by lung ultrasound in ambulatory heart failure patients. European Heart Journal, 37, pp. 1244-1251. (doi: 10.1093/eurheartj/ehv745)

Kristensen, S. L. et al. (2016) Geographic variations in the PARADIGM-HF heart failure trial. European Heart Journal, 37, pp. 3167-3174. (doi: 10.1093/eurheartj/ehw226)

Carrick, D., Haig, C., Watkins, S., Ahmed, N., McEntegart, M., Petrie, M. C., Eteiba, H., Hood, S., Watkins, S., Lindsay, M. M., Davie, A., Mahrous, A., Mordi, I., Rauhalammi, S., Sattar, N., Welsh, P., Radjenovic, A., Ford, I., Oldroyd, K., Berry, C. (2016) Myocardial hemorrhage after acute reperfused ST-segment-elevation myocardial infarction. Circulation: Cardiovascular Imaging, 9, (doi: 10.1161/CIRCIMAGING.115.004148)

Jackson, C. E., Haig, C., Welsh, P., Dalzell, J. R., Tsorlalis, I. K., McConnachie, A., Preiss, D., Anker, S. D., Sattar, N., Petrie, M. C., Gardner, R. S., McMurray, J. J. V. (2016) The incremental prognostic and clinical value of multiple novel biomarkers in heart failure. European Journal of Heart Failure, 18, pp. 1491-1498. (doi: 10.1002/ejhf.543)

Emdin, C. A., Conrad, N., Kiran, A., Salimi-Khorshidi, G., Woodward, M., Anderson, S. G., Mohseni, H., Dargie, H. J., Hardman, S. M.C., McDonagh, T., McMurray, J. J.V., Cleland, J. G.F., Rahimi, K. (2016) Variation in hospital performance for heart failure management in the National Heart Failure Audit for England and Wales. Heart, 103, pp. 55-62. (doi: 10.1136/heartjnl-2016-309706)

2015

Cleland, J. G.F., Mareev, Y. (2015) CRT for heart failure and ESRD: more trials or more thought needed? Journal of the American College of Cardiology, 66, pp. 2630-2632. (doi: 10.1016/j.jacc.2015.10.022)

Solbu, M. D., Thomson, P. C., Macpherson, S., Findlay, M. D., Stevens, K. K., Patel, R. K., Padmanabhan, S., Jardine, A. G., Mark, P. B. (2015) Serum phosphate and social deprivation independently predict all-cause mortality in chronic kidney disease. BMC Nephrology, 16, (doi: 10.1186/s12882-015-0187-1)

Linneberg, A. et al. (2015) Effect of smoking on blood pressure and resting heart rate: a Mendelian randomization meta-analysis in the CARTA Consortium. Circulation: Cardiovascular Genetics, 8, pp. 832-841. (doi: 10.1161/circgenetics.115.001225)

Day, F. R. et al. (2015) Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility, and BRCA1-mediated DNA repair [editorial comment] Obstetrical and Gynecological Survey, 70, pp. 758-762. (doi: 10.1097/01.ogx.0000473766.71624.99)

Artigas, M. S. et al. (2015) Sixteen new lung function signals identified through 1000 Genomes Project reference panel imputation. Nature Communications, 6, (doi: 10.1038/ncomms9658)

Williams, B., MacDonald, T. M., Morant, S., Webb, D. J., Sever, P., McInnes, G., Ford, I., Cruickshank, J. K., Caulfield, M. J., Salsbury, J., Mackenzie, I., Padmanabhan, S., Brown, M. J. (2015) Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial. Lancet, 386, pp. 2059-2068. (doi: 10.1016/S0140-6736(15)00257-3)

van Leeuwen, E. M. et al. (2015) Fine mapping the CETP region reveals a common intronic insertion associated to HDL-C. npj Aging and Mechanisms of Disease, 1, (doi: 10.1038/npjamd.2015.11)

Simpson, J., Jhund, P. S., Silva Cardoso, J., Martinez, F., Mosterd, A., Ramires, F., Rizkala, A. R., Senni, M., Squire, I., Gong, J., Lefkowitz, M. P., Shi, V. C., Desai, A. S., Rouleau, J. L., Swedberg, K., Zile, M. R., McMurray, J. J.V., Packer, M., Solomon, S. D. (2015) Comparing LCZ696 with Enalapril according to baseline risk using the MAGGIC and EMPHASIS-HF risk scores. Journal of the American College of Cardiology, 66, pp. 2059-2071. (doi: 10.1016/j.jacc.2015.08.878)

Jolicœur, E. M., Dunning, A., Castelvecchio, S., Dabrowski, R., Waclawiw, M. A., Petrie, M. C., Stewart, R., Jhund, P. S., Desvigne-Nickens, P., Panza, J. A., Bonow, R. O., Sun, B., San, T. R., Al-Khalidi, H. R., Rouleau, J. L., Velazquez, E. J., Cleland, J. G.F. (2015) Importance of angina in patients with coronary disease, heart failure, and left ventricular systolic dysfunction. Journal of the American College of Cardiology, 66, pp. 2092-2100. (doi: 10.1016/j.jacc.2015.08.882)

Day, F. R. et al. (2015) Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair. Nature Genetics, 47, pp. 1294-1303. (doi: 10.1038/ng.3412)

Gong, Y., McDonough, C. W., Beitelshees, A. L., Rouby, N. E., Hiltunen, T. P., O’Connell, J. R., Padmanabhan, S., Langaee, T. Y., Hall, K., Schmidt, S. O.F., Curry, R. W., Gums, J. G., Donner, K. M., Kontula, K. K., Bailey, K. R., Boerwinkle, E., Takahashi, A., Tanaka, T., Kubo, M., Chapman, A. B., Turner, S. T., Pepine, C. J., Cooper-DeHoff, R. M., Johnson, J. A. (2015) PTPRD gene associated with blood pressure response to atenolol and resistant hypertension. Journal of Hypertension, 33, pp. 2278-2285. (doi: 10.1097/hjh.0000000000000714)

Pellicori, P., Joseph, A. C., Zhang, J., Lukaschuk, E., Sherwi, N., Bourantas, C. V., Loh, H., Clark, A. L., Cleland, J. G.F. (2015) The relationship of QRS morphology with cardiac structure and function in patients with heart failure. Clinical Research in Cardiology, 104, pp. 935-945. (doi: 10.1007/s00392-015-0861-0)

Inglis, S. C., Clark, R. A., Dierckx, R., Prieto-Merino, D., Cleland, J. G.F. (2015) Structured telephone support or non-invasive telemonitoring for patients with heart failure. Cochrane Database of Systematic Reviews, 2015, (doi: 10.1002/14651858.CD007228.pub3)

Jhund, P., Fu, M., Bayram, E., Chen, C.-H., Negrusz-Kawecka, M., Rosenthal, A., Desai, A. S., Lefkowitz, M. P., Rizkala, A. R., Rouleau, J. L., Shi, V. C., Solomon, S. D., Swedberg, K., Zile, M. R., McMurray, J. J.V., Packer, M. (2015) Efficacy and safety of LCZ696 (sacubitril-valsartan) according to age: insights from PARADIGM-HF. European Heart Journal, 36, pp. 2576-2584. (doi: 10.1093/eurheartj/ehv330)

Farag, M., Mabote, T., Shoaib, A., Zhang, J., Nabhan, A. F., Clark, A. L., Cleland, J. G. (2015) Hydralazine and nitrates alone or combined for the management of chronic heart failure: a systematic review. International Journal of Cardiology, 196, pp. 61-69. (doi: 10.1016/j.ijcard.2015.05.160)

Mareev, Y., Cleland, J. G.F. (2015) Should β-blockers be used in patients with heart failure and atrial fibrillation? Clinical Therapeutics, 37, pp. 2215-2224. (doi: 10.1016/j.clinthera.2015.08.017)

Shadman, R., Poole, J. E., Dardas, T. F., Mozaffarian, D., Cleland, J. G.F., Swedberg, K., Maggioni, A. P., Anand, I. S., Carson, P. E., Miller, A. B., Levy, W. C. (2015) A novel method to predict the proportional risk of sudden cardiac death in heart failure: derivation of the Seattle Proportional Risk Model. Heart Rhythm, 12, pp. 2069-2077. (doi: 10.1016/j.hrthm.2015.06.039)

Patel, R., Jeemon, P., Stevens, K., Mccallum, L., Hastie, C., Schneider, A., Jardine, A., Mark, P., Padmanabhan, S. (2015) Association between serum phosphate and calcium, long-term blood pressure, and mortality in treated hypertensive adults. Journal of Hypertension, 33, pp. 2046-2053. (doi: 10.1097/hjh.0000000000000659)

Butcher, C., Mareev, Y., Markides, V., Mason, M., Wong, T., Cleland, J.G.F. (2015) Cardiac resynchronization therapy update: evolving indications, expanding benefit? Current Cardiology Reports, 17, (doi: 10.1007/s11886-015-0641-5)

Frankenstein, L., Fröhlich, H., Cleland, J. G.F. (2015) Multidisciplinary approach for patients hospitalized with heart failure. Revista Española de Cardiología (English Edition), 68, pp. 885-891. (doi: 10.1016/j.rec.2015.05.008)

Jhund, P., McMurray, J. J.V., Chaturvedi, N., Brunel, P., Desai, A. S., Finn, P. V., Haffner, S. M., Solomon, S. D., Weinrauch, L. A., Claggett, B. L., Pfeffer, M. A. (2015) Mortality following a cardiovascular or renal event in patients with type 2 diabetes in the ALTITUDE trial. European Heart Journal, 36, pp. 2463-2469. (doi: 10.1093/eurheartj/ehv295)

Cleland, J. G.F., Freemantle, N. (2015) QRS morphology as a predictor of the response to cardiac resynchronisation therapy: fact or fashion? Heart, 101, pp. 1441-1443. (doi: 10.1136/heartjnl-2015-307553)

Wannamethee, S. G., Welsh, P., Papacosta, O., Lennon, L., Whincup, P. H., Sattar, N. (2015) Copeptin, insulin resistance, and risk of incident diabetes in older men. Journal of Clinical Endocrinology and Metabolism, 100, pp. 3332-3339. (doi: 10.1210/JC.2015-2362)

Harrison, J. K., Clegg, A., Conroy, S. P., Young, J. (2015) Managing frailty as a long-term condition. Age and Ageing, 44, pp. 732-735. (doi: 10.1093/ageing/afv085)

Platz, E., Jhund, P. S., Campbell, R. T., McMurray, J. (2015) Assessment and prevalence of pulmonary oedema in contemporary acute heart failure trials: a systematic review. European Journal of Heart Failure, 17, pp. 906-916. (doi: 10.1002/ejhf.321)

Damy, T., Hobkirk, J., Walters, M., Ciobanu, A., Rigby, A. S., Kallvikbacka-Bennett, A., Guellich, A., Dubois-Randé, J.-L., Hittinger, L., Clark, A. L., Cleland, J. G.F. (2015) Development of a human model for the study of effects of hypoxia, exercise, and sildenafil on cardiac and vascular function in chronic heart failure. Journal of Cardiovascular Pharmacology, 66, pp. 229-238. (doi: 10.1097/FJC.0000000000000262)

Dierckx, R., Cleland, J. G.F., Pellicori, P., Zhang, J., Goode, K., Putzu, P., Boyalla, V., Clark, A. L. (2015) If home telemonitoring reduces mortality in heart failure, is this just due to better guideline-based treatment? Journal of Telemedicine and Telecare, 21, pp. 331-339. (doi: 10.1177/1357633X15574947)

Stut, W., Deighan, C., Cleland, J. G., Jaarsma, T. (2015) Adherence to self-care in patients with heart failure in the HeartCycle study. Patient Preference and Adherence, 9, pp. 1195-1206. (doi: 10.2147/PPA.S88482)

Morris, R. W. et al. (2015) Heavier smoking may lead to a relative increase in waist circumference: evidence for a causal relationship from a Mendelian randomisation meta-analysis. The CARTA consortium: Table 1. BMJ Open, 5, (doi: 10.1136/bmjopen-2015-008808)

Quinn, T. J., Alghamdi, J., Padmanabhan, S., Porteous, D. J., Smith, B. H., Hocking, L., Deary, I. J., Gallacher, J., Messow, M., Stott, D. J. (2015) Association between cognition and gene polymorphisms involved in thrombosis and haemostasis. Age, 37, pp. 80. (doi: 10.1007/s11357-015-9820-y)

Jhund, P. S., Anand, I. S., Komajda, M., Claggett, B. L., McKelvie, R. S., Zile, M. R., Carson, P. E., McMurray, J. J.V. (2015) Changes in N-terminal pro-B-type natriuretic peptide levels and outcomes in heart failure with preserved ejection fraction: an analysis of the I-Preserve study. European Journal of Heart Failure, 17, pp. 809-817. (doi: 10.1002/ejhf.274)

Jackson, C. E., Haig, C., Welsh, P., Dalzell, J. R., Tsorlalis, I. K., McConnachie, A., Preiss, D., McInnes, I. B., Sattar, N., Petrie, M. C., Gardner, R. S., McMurray, J. J.V. (2015) Combined free light chains are novel predictors of prognosis in heart failure. JACC: Heart Failure, 3, pp. 618-625. (doi: 10.1016/j.jchf.2015.03.014)

Blyth, M., Anthony, I., Francq, B., Brooksbank, K., Downie, P., Powell, A., Jones, B., MacLean, A., McConnachie, A., Norrie, J. (2015) Diagnostic accuracy of the Thessaly test, standardised clinical history and other clinical examination tests (Apley's, McMurray's and joint line tenderness) for meniscal tears in comparison with magnetic resonance imaging diagnosis. Health Technology Assessment, 19, pp. 1-62. (doi: 10.3310/hta19620)

Rush, C. J., Campbell, R. T., Jhund, P. S., Connolly, E. C., Preiss, D., Gardner, R. S., Petrie, M. C., McMurray, J. J.V. (2015) Falling cardiovascular mortality in heart failure with reduced ejection fraction and implications for clinical trials. JACC: Heart Failure, 3, pp. 603-614. (doi: 10.1016/j.jchf.2015.03.013)

Menni, C. et al. (2015) Metabolomic identification of a novel pathway of blood pressure regulation involving hexadecanedioate. Hypertension, 66, pp. 422-429. (doi: 10.1161/HYPERTENSIONAHA.115.05544)

Cleland, J. G.F., Mareev, Y., Linde, C. (2015) Reflections on EchoCRT: sound guidance on QRS duration and morphology for CRT? European Heart Journal, 36, pp. 1948-1951. (doi: 10.1093/eurheartj/ehv264)

Askevold, E. T., Gullestad, L., Nymo, S., Kjekshus, J., Yndestad, A., Latini, R., Cleland, J. G.F., McMurray, J. J.V., Aukrust, P., Ueland, T. (2015) Secreted frizzled related protein 3 in chronic heart failure: analysis from the controlled rosuvastatin multinational trial in heart failure (CORONA) PLoS ONE, 10, (doi: 10.1371/journal.pone.0133970)

Joshi, P. K. et al. (2015) Directional dominance on stature and cognition in diverse human populations. Nature, 523, pp. 459-462. (doi: 10.1038/nature14618)

Raphael, C. E., Finegold, J. A., Barron, A. J., Whinnett, Z. I., Mayet, J., Linde, C., Cleland, J. G.F., Levy, W. C., Francis, D. P. (2015) The effect of duration of follow-up and presence of competing risk on lifespan-gain from implantable cardioverter defibrillator therapy: who benefits the most? European Heart Journal, 36, pp. 1676-1688. (doi: 10.1093/eurheartj/ehv102)

Mentz, R. J., Metra, M., Cotter, G., Milo, O., McKendry, C., Chiswell, K., Davison, B. A., Cleland, J. G.F., Bloomfield, D. M., Dittrich, H. C., Fiuzat, M., Ponikowski, P., Givertz, M. M., Voors, A. A., Teerlink, J. R., O'Connor, C. M. (2015) Early vs. late worsening heart failure during acute heart failure hospitalization: insights from the PROTECT trial. European Journal of Heart Failure, 17, pp. 697-706. (doi: 10.1002/ejhf.308)

Ferrari, R., Böhm, M., Cleland, J. G.F., Paulus, W. J.S., Pieske, B., Rapezzi, C., Tavazzi, L. (2015) Heart failure with preserved ejection fraction: uncertainties and dilemmas. European Journal of Heart Failure, 17, pp. 665-671. (doi: 10.1002/ejhf.304)

Mccallum, L., Panniyammakal, J., Hastie, C. E., Hewitt, J., Patel, R., Jones, G. C., Muir, S., Walters, M., Sattar, N., Dominiczak, A., Padmanabhan, S. (2015) Longitudinal blood pressure control, long-term mortality and predictive utility of serum liver enzymes and bilirubin in hypertensive patients. Hypertension, 66, pp. 37-43. (doi: 10.1161/HYPERTENSIONAHA.114.04915)

Carrick, D., Haig, C., Rauhalammi, S., Ahmed, N., Mordi, I., McEntegart, M., Petrie, M., Eteiba, H., Lindsay, M., Watkins, S., Hood, S., Davie, A., Marous, A., Sattar, N., Welsh, P., Tzemos, N., Radjenovic, A., Ford, I., Oldroyd, K., Berry, C. (2015) Pathophysiology of LV remodeling in survivors of STEMI : inflammation, remote myocardium, and prognosis. JACC: Cardiovascular Imaging, 8, pp. 779-789. (doi: 10.1016/j.jcmg.2015.03.007)

Pellicori, P., Kallvikbacka-Bennett, A., Dierckx, R., Zhang, J., Putzu, P., Cuthbert, J., Boyalla, V., Shoaib, A., Clark, A. L., Cleland, J. G.F. (2015) Prognostic significance of ultrasound-assessed jugular vein distensibility in heart failure. Heart, 101, pp. 1149-1158. (doi: 10.1136/heartjnl-2015-307558)

Zannad, F., Greenberg, B., Cleland, J. G.F., Gheorghiade, M., van Veldhuisen, D. J., Mehra, M. R., Anker, S. D., Byra, W. M., Fu, M., Mills, R. M. (2015) Rationale and design of a randomized, double-blind, event-driven, multicentre study comparing the efficacy and safety of oral rivaroxaban with placebo for reducing the risk of death, myocardial infarction or stroke in subjects with heart failure and significant coronary artery disease following an exacerbation of heart failure: the COMMANDER HF trial. European Journal of Heart Failure, 17, pp. 735-742. (doi: 10.1002/ejhf.266)

Lip, S., Carlin, C., McCallum, L., Touyz, R.H., Dominiczak, A.F., Padmanabhan, S. (2015) Incidence and prognosis of cancer associated with digoxin and common antihypertensive drugs. Journal of Hypertension, 33, pp. e45. (doi: 10.1097/01.hjh.0000467465.54504.ae)

Inglis, S. C., Conway, A., Cleland, J. G.F., Clark, R. A. (2015) Is age a factor in the success or failure of remote monitoring in heart failure? Telemonitoring and structured telephone support in elderly heart failure patients. European Journal of Cardiovascular Nursing, 14, pp. 248-255. (doi: 10.1177/1474515114530611)

Clarke, T.-K., Hall, L.S., Fernandez-Pujals, A.M., MacIntyre, D.J., Thomson, P., Hayward, C., Smith, B.H., Padmanabhan, S., Hocking, L.J., Deary, I.J., Porteous, D.J., McIntosh, A.M. (2015) Major depressive disorder and current psychological distress moderate the effect of polygenic risk for obesity on body mass index. Translational Psychiatry, 5, (doi: 10.1038/tp.2015.83)

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Costanzo, P., Cleland, J. G.F., Pellicori, P., Clark, A. L., Hepburn, D., Kilpatrick, E. S., Perrone-Filardi, P., Zhang, J., Atkin, S. L. (2015) The obesity paradox in type 2 diabetes mellitus: relationship of body mass index to prognosis: a cohort study. Annals of Internal Medicine, 162, pp. 610-618. (doi: 10.7326/M14-1551)

Fulton, R. L., Walters, M. R., Morton, R., Touyz, R. M., Dominiczak, A. F., Morrison, D. S., Padmanabhan, S., Meredith, P. A., McInnes, G. T., Dawson, J. (2015) Acetaminophen use and risk of myocardial infarction and stroke in a hypertensive cohort. Hypertension, 65, pp. 1008-U596. (doi: 10.1161/HYPERTENSIONAHA.114.04945)

Filippatos, G., Khan, S. S., Ambrosy, A. P., Cleland, J. G.F., Collins, S. P., Lam, C. S.P., Angermann, C. E., Ertl, G., Dahlström, U., Hu, D., Dickstein, K., Perrone, S. V., Ghadanfar, M., Bermann, G., Noe, A., Schweizer, A., Maier, T., Gheorghiade, M. (2015) International REgistry to assess medical practice with lOngitudinal obseRvation for Treatment of Heart Failure (REPORT-HF): rationale for and design of a global registry. European Journal of Heart Failure, 17, pp. 527-533. (doi: 10.1002/ejhf.262)

Davison, B. A., Metra, M., Cotter, G., Massie, B. M., Cleland, J. G.F., Dittrich, H. C., Edwards, C., Filippatos, G., Givertz, M. M., Greenberg, B., Ponikowski, P., Voors, A. A., O’Connor, C. M., Teerlink, J. R. (2015) Worsening heart failure following admission for acute heart failure: a pooled analysis of the PROTECT and RELAX-AHF studies. JACC: Heart Failure, 3, pp. 395-403. (doi: 10.1016/j.jchf.2015.01.007)

Goncalves, A., Claggett, B., Jhund, P. S., Rosamond, W., Deswal, A., Aguilar, D., Shah, A. M., Cheng, S., Solomon, S. D. (2015) Alcohol consumption and risk of heart failure: the Atherosclerosis Risk in Communities Study. European Heart Journal, 36, pp. 939-945. (doi: 10.1093/eurheartj/ehu514)

Ali, M., Lyden, P., Brady, M. (2015) Aphasia and dysarthria in acute stroke: recovery and functional outcome. International Journal of Stroke, 10, pp. 400-406. (doi: 10.1111/ijs.12067)

Feinstein, M. J., Jhund, P., Kang, J., Ning, H., Maggioni, A., Wikstrand, J., Kjekshus, J., Tavazzi, L., McMurray, J., Lloyd-Jones, D. M. (2015) Do statins reduce the risk of myocardial infarction in patients with heart failure? A pooled individual-level reanalysis of CORONA and GISSI-HF. European Journal of Heart Failure, 17, pp. 434-441. (doi: 10.1002/ejhf.247)

Menni, C., Mangino, M., Cecelja, M., Psatha, M., Brosnan, M. J., Trimmer, J., Mohney, R. P., Chowienczyk, P., Padmanabhan, S., Spector, T. D., Valdes, A. M. (2015) Metabolomic study of carotid–femoral pulse-wave velocity in women. Journal of Hypertension, 33, pp. 791-796. (doi: 10.1097/HJH.0000000000000467)

Abdul-Rahim, A. H., Perez, A.-C., Fulton, R. L., Jhund, P. S., Latini, R., Tognoni, G., Wikstrand, J., Kjekshus, J., Lip, G. Y.H., Maggioni, A. P., Tavazzi, L., Lees, K. R., McMurray, J. (2015) Risk of stroke in chronic heart failure patients without atrial fibrillation: analysis of the controlled rosuvastatin in multinational trial heart failure (corona) and the gruppo italiano per lo studio della sopravvivenza nell'insufficienza cardiaca-heart failure (gissi-hf) trials. Circulation, 131, pp. 1486-1494. (doi: 10.1161/CIRCULATIONAHA.114.013760)

Cleland, J. G.F., Butcher, C. (2015) When is it appropriate to withdraw cardiac resynchronization therapy? Guesses and evidence. JACC: Heart Failure, 3, pp. 337-339. (doi: 10.1016/j.jchf.2015.01.003)

Pellicori, P., Zhang, J., Lukaschuk, E., Joseph, A. C., Bourantas, C. V., Loh, H., Bragadeesh, T., Clark, A. L., Cleland, J. G.F. (2015) Left atrial function measured by cardiac magnetic resonance imaging in patients with heart failure: clinical associations and prognostic value. European Heart Journal, 36, pp. 733-742. (doi: 10.1093/eurheartj/ehu405)

Vazir, A., Claggett, B., Jhund, P., Castagno, D., Skali, H., Yusuf, S., Swedberg, K., Granger, C.B., McMurray, J.J.V., Pfeffer, M. A., Solomon, S.D. (2015) Prognostic importance of temporal changes in resting heart rate in heart failure patients: an analysis of the CHARM program. European Heart Journal, 36, pp. 669-675. (doi: 10.1093/eurheartj/ehu401)

Jankowska, E. A., Wojtas, K., Kasztura, M., Mazur, G., Butrym, A., Kalicinska, E., Rybinska, I., Skiba, J., von Haehling, S., Doehner, W., Anker, S. D., Banasiak, W., Cleland, J. G.F., Ponikowski, P. (2015) Bone marrow iron depletion is common in patients with coronary artery disease. International Journal of Cardiology, 182, pp. 517-522. (doi: 10.1016/j.ijcard.2014.10.006)

Metra, M., Cotter, G., El-Khorazaty, J., Davison, B. A., Milo, O., Carubelli, V., Bourge, R. C., Cleland, J. G., Jondeau, G., Krum, H., O'Connor, C. M., Parker, J. D., Torre-Amione, G., van Veldhuisen, D. J., Rainisio, M., Kobrin, I., McMurray, J. J., Teerlink, J. R. (2015) Acute heart failure in the elderly: differences in clinical characteristics, outcomes, and prognostic factors in the VERITAS Study. Journal of Cardiac Failure, 21, pp. 179-88. (doi: 10.1016/j.cardfail.2014.12.012)

Harrison, J. K., Clipsham, L. E., Cooke, C. M., Warwick, G., Burton, J. O. (2015) Establishing a supportive care register improves end-of-life care for patients with advanced chronic kidney disease. Nephron, 129, pp. 209-213. (doi: 10.1159/000371888)

Padmanabhan, S., Caulfield, M., Dominiczak, A. (2015) Genetic and molecular aspects of hypertensin. Circulation Research, 116, pp. 937-959. (doi: 10.1161/CIRCRESAHA.116.303647)

Pellicori, P., Cleland, J. G.F. (2015) Is the epidemic of heart disease really over or just evolving? American Journal of Medicine, 128, pp. e17. (doi: 10.1016/j.amjmed.2014.09.018)

Dierckx, R., Cleland, J. G.F., Parsons, S., Putzu, P., Pellicori, P., Dicken, B., Boyalla, V., Clark, A. L. (2015) Prescribing patterns to optimize heart rate: analysis of 1,000 consecutive outpatient appointments to a single heart failure clinic over a 6-month period. JACC: Heart Failure, 3, pp. 224-230. (doi: 10.1016/j.jchf.2014.11.003)

Khand, A. U., Chew, P. G., Douglas, H., Jones, J., Jan, A., Cleland, J.G.F. (2015) The effect of carvedilol on b-type natriuretic peptide and cardiac function in patients with heart failure and persistent atrial fibrillation. Cardiology, 130, pp. 153-158. (doi: 10.1159/000368746)

McCallum, L., Lip, S., Padmanabhan, S. (2015) The hidden hand of chloride in hypertension. Pflügers Archiv - European Journal of Physiology, 467, pp. 595-603. (doi: 10.1007/s00424-015-1690-8)

Pellicori, P., Cleland, J. G.F. (2015) Update on management of heart failure with preserved ejection fraction. Current Opinion in Cardiology, 30, pp. 173-178. (doi: 10.1097/HCO.0000000000000152)

Badar, A. A., Perez-Moreno, A. C., Hawkins, N. M., Brunton, A. P.T., Jhund, P. S., Wong, C. M., Solomon, S. D., Granger, C. B., Yusuf, S., Pfeffer, M. A., Swedberg, K., Gardner, R. S., Petrie, M. C., McMurray, J. J.V. (2015) Clinical characteristics and outcomes of patients with angina and heart failure in the CHARM (Candesartan in Heart Failure Assessment of Reduction in Mortality and Morbidity) programme. European Journal of Heart Failure, 17, pp. 196-204. (doi: 10.1002/ejhf.221)

Kristensen, S. L., Jhund, P. S., Køber, L., Preiss, D., Kjekshus, J., McKelvie, R. S., Zile, M. R., Anand, I. S., Wikstrand, J. G.F., Wedel, H., Komajda, M., Carson, P. E., Cleland, J., McMurray, J. J.V. (2015) Comparison of outcomes after hospitalization for worsening heart failure, myocardial infarction, and stroke in patients with heart failure and reduced and preserved ejection fraction. European Journal of Heart Failure, 17, pp. 169-176. (doi: 10.1002/ejhf.211)

Wade, K. H., Forouhi, N. G., Cook, D. G., Johnson, P., McConnachie, A., Morris, R. W., Rodriguez, S., Ye, Z., Ebrahim, S., Padmanabhan, S., Watt, G., Bruckdorfer, K. R., Wareham, N. J., Whincup, P. H., Chanock, S., Sattar, N., Lawlor, D. A., Davey Smith, G., Timpson, N. J. (2015) Variation in the SLC23A1 gene does not influence cardiometabolic outcomes to the extent expected given its association with L-ascorbic acid. American Journal of Clinical Nutrition, 101, pp. 202-209. (doi: 10.3945/ajcn.114.092981)

Metra, M., Mentz, R. J., Chiswell, K., Bloomfield, D. M., Cleland, J. G.F., Cotter, G., Davison, B. A., Dittrich, H. C., Fiuzat, M., Givertz, M. M., Lazzarini, V., Mansoor, G. A., Massie, B. M., Ponikowski, P., Teerlink, J. R., Voors, A. A., O'Connor, C. M. (2015) Acute heart failure in elderly patients: worse outcomes and differential utility of standard prognostic variables. Insights from the PROTECT trial. European Journal of Heart Failure, 17, pp. 109-118. (doi: 10.1002/ejhf.207)

Dickstein, K., Normand, C., Anker, S.D., Auricchio, A., Lundqvist Blomstrom, C., Bogale, N., Cleland, J., Filippatos, G., Gasparini, M., Gitt, A., Hindricks, G., Kuck, K.-H., Ponikowski, P., Stellbrink, C., Ruschitzka, F., Linde, C. (2015) European cardiac resynchronization therapy survey II: rationale and design. Europace, 17, pp. 137-141. (doi: 10.1093/europace/euu312)

Kristensen, S. L. L., Køber, L., Jhund, P. S., Solomon, S. D., Kjekshus, J., McKelvie, R. S., Zile, M. R., Granger, C. B., Wikstrand, J., Komajda, M., Carson, P. E., Pfeffer, M. A., Swedberg, K., Wedel, H., Yusuf, S., McMurray, J. J. V. (2015) International geographic variation in event rates in trials of heart failure with preserved and reduced ejection fraction. Circulation, 131, pp. 43-53. (doi: 10.1161/CIRCULATIONAHA.114.012284)

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What types of healthcare data do we use?

  • Research cohorts: our researchers have substantial experience and expertise working with the UK Biobank cohort.
  • Linked routine healthcare data: West of Scotland Safe Haven, Clinical Practice Research Datalink (CPRD), Secure Anonymised Data Linkage (SAIL) Wales, Understanding Pathways into Care homes using Data (UnPiCD study) including linkage to national renal and cancer registries.
  • Trial data: individual participant-level data (IPD) from trials via publicly available data-sharing platforms (e.g., Vivli), Glasgow-run repositories for trial IPD (Virtual Trials Archives), and Glasgow-generated IPD from practice-changing trials in heart failure, stroke and chronic kidney disease.

What can we offer with our healthcare data?

  • Practice-changing evidence-based-medicine.
  • Pilot data for grant/funding applications.
  • Strong links with industry partners.
  • Strong collaboration with NHS data providers.